APOA4

Summary

Gene Symbol: APOA4
Description: apolipoprotein A4
Alias: apolipoprotein A-IV, apo-AIV, apoA-IV
Species: human
Products:     APOA4

Top Publications

  1. Peignon G, Thenet S, Schreider C, Fouquet S, Ribeiro A, Dussaulx E, et al. E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: a role for the hepatic nuclear factor 4. J Biol Chem. 2006;281:3560-8 pubmed
    ..Altogether, our results suggest that E-cadherin controls enterocyte-specific expression of genes, such as the apoA-IV gene, through the control of hepatic nuclear factor 4alpha nuclear abundance. ..
  2. van der Net J, Janssens A, Defesche J, Kastelein J, Sijbrands E, Steyerberg E. Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia. Am J Cardiol. 2009;103:375-80 pubmed publisher
    ..To improve genome-based prediction of CHD, larger numbers of genetic variants need to be identified that either on their own or in gene-gene interaction have substantial effects on CHD risk. ..
  3. Miltiadous G, Hatzivassiliou M, Bashiardes E, Bairaktari E, Cariolou M, Elisaf M. Genetic polymorphisms of the apolipoprotein A-IV in a Greek population and their relation to plasma lipid and lipoprotein levels. Clin Genet. 2002;62:208-13 pubmed
  4. Talmud P, Hawe E, Martin S, Olivier M, Miller G, Rubin E, et al. Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum Mol Genet. 2002;11:3039-46 pubmed
    ..the relative influence of human APOA5 variants on plasma lipids, compared to the impact of variation in APOC3 and APOA4 which lie in the same cluster...
  5. Vincent S, Planells R, Defoort C, Bernard M, Gerber M, Prudhomme J, et al. Genetic polymorphisms and lipoprotein responses to diets. Proc Nutr Soc. 2002;61:427-34 pubmed
    ..These data provide evidence of the interaction between some SNP and the metabolic response to diets. ..
  6. Karathanasis S. Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes. Proc Natl Acad Sci U S A. 1985;82:6374-8 pubmed
    ..6% identical to rat apoAIV. These results indicate that apoAI, apoCIII, and apoAIV genes are closely linked in the human genome and suggest that all three of them are derived from a common ancestral precursor. ..
  7. Garasto S, Rose G, DeRango F, Berardelli M, Corsonello A, Feraco E, et al. The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. Ann Hum Genet. 2003;67:54-62 pubmed
    The genes coding for apolipoprotein A1 (APOA1), apolipoprotein C3 (APOC3) and apolipoprotein A4 (APOA4) are tandemly organised within a short region on chromosome 11q23-q24...
  8. Saadane A, Petrov A, Mast N, El Darzi N, Dao T, Alnemri A, et al. Mechanisms that minimize retinal impact of apolipoprotein E absence. J Lipid Res. 2018;59:2368-2382 pubmed publisher
    ..abundant cholesterol-related proteins in WT mice and revealed that, of these cholesterol-related proteins, only APOA4 had increased expression in the Apoe-/- retina...
  9. Le Beyec J, Chauffeton V, Kan H, Janvier P, Cywiner Golenzer C, Chatelet F, et al. The -700/-310 fragment of the apolipoprotein A-IV gene combined with the -890/-500 apolipoprotein C-III enhancer is sufficient to direct a pattern of gene expression similar to that for the endogenous apolipoprotein A-IV gene. J Biol Chem. 1999;274:4954-61 pubmed

More Information

Publications188 found, 100 shown here

  1. Lingenhel A, Lhotta K, Neyer U, Heid I, Rantner B, Kronenberg M, et al. Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria. J Lipid Res. 2006;47:2071-9 pubmed
    ..From this investigation of apoA-IV in urine as well as earlier immunohistochemical studies, we conclude that apoA-IV is filtered through the normal glomerulus and is subsequently reabsorbed mainly by proximal tubular cells. ..
  2. Kotnik Halavaty K, Regan J, Mehta K, Laimins L. Human papillomavirus E5 oncoproteins bind the A4 endoplasmic reticulum protein to regulate proliferative ability upon differentiation. Virology. 2014;452-453:223-30 pubmed publisher
    ..Our studies suggest that the A4 protein is an important E5 binding partner that plays a role in regulating cell proliferation ability upon differentiation. ..
  3. Qi L, Liu S, Rifai N, Hunter D, Hu F. Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes. Atherosclerosis. 2007;192:204-10 pubmed
    ..006), whereas APOA4 +347T/A showed significant associations with lower levels of HDL-C (P=0.017)...
  4. Cui R, Li C, Wang J, Dai J. Induction of hepatic miR-34a by perfluorooctanoic acid regulates metabolism-related genes in mice. Environ Pollut. 2019;244:270-278 pubmed publisher
    ..Among the changed genes by miR-34a, the most dominant were metabolism-related genes, such as Fabp3, Cyp7a1, and Apoa4. Our in vivo study indicated that miR-34a mainly exerts a metabolic regulation role, rather than the pro-..
  5. Xu H, Liao Z, Wang C, Wei Y, Liang M. Hepatic transcriptome of the euryhaline teleost Japanese seabass (Lateolabrax japonicus) fed diets characterized by α-linolenic acid or linoleic acid. Comp Biochem Physiol Part D Genomics Proteomics. 2019;29:106-116 pubmed publisher
    ..Lipid metabolism-related genes ApoA1, ApoA4, ApoE, FABP1, FABP3, FABP4, FATP6, and DGAT1, as well as ribosomal proteins L9e, L13e, and S4e, were ..
  6. Yang C, Gu Z, Chong I, Xiong W, Rosseneu M, Yang H, et al. The primary structure of human apolipoprotein A-IV. Biochim Biophys Acta. 1989;1002:231-7 pubmed
    ..In certain positions, however, bona fide sequence heterogeneity or cloning artifact cannot be excluded. ..
  7. Tubb M, Silva R, Fang J, Tso P, Davidson W. A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry. J Biol Chem. 2008;283:17314-23 pubmed publisher
    ..This first structural model of lipid-free apoA-IV should prove useful for designing studies aimed at understanding how apoA-IV interacts with lipids and possibly with unknown protein partners. ..
  8. Walker R, Deng X, Melchior J, Morris J, Tso P, Jones M, et al. The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering. J Biol Chem. 2014;289:5596-608 pubmed publisher
    ..The isotope-assisted cross-linking approach should prove useful for further study of this family of apolipoproteins in both the lipid-free and -bound states. ..
  9. Hachero Cruzado I, Rodríguez Rua A, Román Padilla J, Ponce M, Fernández Díaz C, Manchado M. Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels. Comp Biochem Physiol Part D Genomics Proteomics. 2014;12:61-73 pubmed publisher
    ..RNA-seq analysis showed that larvae fed HTAG activated coordinately the transcription of apolipoproteins (apob, apoa4, apoc2, apoe, and apobec2) and other related transcripts involved in chylomicron formation, likely to facilitate ..
  10. Xie X, Chu H, Xu Y, Hua L, Wang Z, Huang P, et al. Proteomics study of serum exosomes in Kawasaki disease patients with coronary artery aneurysms. Cardiol J. 2018;: pubmed publisher
    ..The expression levels of 4 proteins (TN, RBP4, LRG1, and APOA4) were validated using western blotting...
  11. Menzel H, Dieplinger H, Sandholzer C, Karadi I, Utermann G, Csaszar A. Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants. Hum Mutat. 1995;5:58-65 pubmed
    ..DNA-sequencing revealed two point mutations (Arg285-->Cys and Thr347-->Ser) in exon 3 of apo A-IV-Budapest-1 and a Glu-->Lys substitution at position 24 in exon 2 of apo A-IV-Budapest-2. ..
  12. Fullerton S, Buchanan A, Sonpar V, Taylor S, Smith J, Carlson C, et al. The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster. Hum Genet. 2004;115:36-56 pubmed
    ..The implications of these findings for other haplotype-based descriptions of human variation are discussed. ..
  13. Hanniman E, Lambert G, Inoue Y, Gonzalez F, Sinal C. Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha. J Lipid Res. 2006;47:2503-14 pubmed
    ..Together, these results indicate that the induction of apoA-IV expression in fasting and diabetes likely involves PGC-1 alpha-mediated coactivation of HNF-4 alpha in addition to glucocorticoid-dependent actions. ..
  14. Li Y, Wei Y, Fu X, Hao D, Xue Z, Gong H, et al. The apolipoprotein CIII enhancer regulates both extensive histone modification and intergenic transcription of human apolipoprotein AI/CIII/AIV genes but not apolipoprotein AV. J Biol Chem. 2008;283:28436-44 pubmed publisher
    ..These results demonstrate that the apoCIII enhancer contributes to the maintenance of an active chromatin subdomain of the apoAI/CIII/AIV genes, but not apoAV. ..
  15. Liu Z, Hu M, Baum L, Thomas G, Tomlinson B. Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese. Atherosclerosis. 2010;208:427-32 pubmed publisher
    ..Some common polymorphisms and haplotypes in APOA5 are closely associated with FCH in Hong Kong Chinese, and these differ from those found in Caucasians. ..
  16. Dandekar A, Qiu Y, Kim H, Wang J, Hou X, Zhang X, et al. Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin. J Biol Chem. 2016;291:23149-23158 pubmed
    ..CREBH directly activates expression of the gene encoding Apolipoprotein A4 (ApoA4) under LPS challenge, leading to modulation of high-density lipoprotein (HDL) in animals...
  17. Lyu L, Wen H, Li Y, Li J, Zhao J, Zhang S, et al. Deep Transcriptomic Analysis of Black Rockfish (Sebastes schlegelii) Provides New Insights on Responses to Acute Temperature Stress. Sci Rep. 2018;8:9113 pubmed publisher
    ..growth response protein 1, bile salt export pump, abcb11, hsp70a, rtp3, 1,25-dihydroxyvitamin d(3) 24-hydroxylase, apoa4, transcription factor jun-b-like and an uncharacterized gene) were observed among all three comparisons, strongly ..
  18. Liu S, Song Y, Hu F, Niu T, Ma J, Gaziano M, et al. A prospective study of the APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster and risk of incident myocardial infarction in men. Atherosclerosis. 2004;177:119-26 pubmed
  19. Dallongeville J, Cottel D, Wagner A, Ducimetiere P, Ruidavets J, Arveiler D, et al. The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides. BMC Med Genet. 2008;9:84 pubmed publisher
    ..The APOA5 Ser19Trp, APOA5 -12,238T>C, APOA4 Thr347Ser, APOC3 -482C>T and APOC3 3238C>G (SstI) polymorphisms were analyzed in a representative population ..
  20. Borlak J, Langer F, Chatterji B. Serum proteome mapping of EGF transgenic mice reveal mechanistic biomarkers of lung cancer precursor lesions with clinical significance for human adenocarcinomas. Biochim Biophys Acta Mol Basis Dis. 2018;: pubmed publisher
    ..Moreover, serum ApoA4, ApoH and ApoM were 2-, 2- and 6-fold repressed; however tissue ApoM and sphingosine-1-phosphate receptor ..
  21. Fang C, Chen M, Chang T, Wu C, Chang J, Huang H, et al. Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes. Int J Mol Sci. 2018;19: pubmed publisher
    ..5. Nine genes in stretched monocytes (Apoa4, Hmgcs2, Apol8, Srebf1, Acsm4, Fabp1, Acox2, Acsl6, Gk)..
  22. Cardona F, Tinahones F, Collantes E, Garcia Fuentes E, Escudero A, Soriguer F. Response to a urate-lowering diet according to polymorphisms in the apolipoprotein AI-CIII-AIV cluster. J Rheumatol. 2005;32:903-5 pubmed
    ..Changes in triglycerides were also influenced by the apolipoprotein AI XmnI polymorphism (p = 0.04), suggesting a gene-diet interaction (p = 0.03). ..
  23. Weinberg R, Cook V. Distinctive structure and interfacial activity of the human apolipoprotein A-IV 347S isoprotein. J Lipid Res. 2010;51:2664-71 pubmed publisher
    ..Together, these observations establish that the T347S substitution alters the conformation of apo A-IV and lowers its interfacial activity-changes that could account for the effect of this polymorphism on postprandial lipid metabolism. ..
  24. Wu Wong J, Li X, Chen Y. Different vitamin D receptor agonists exhibit differential effects on endothelial function and aortic gene expression in 5/6 nephrectomized rats. J Steroid Biochem Mol Biol. 2015;148:202-9 pubmed publisher
    ..Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol ..
  25. Archer A, Sauvaget D, Chauffeton V, Bouchet P, Chambaz J, Pincon Raymond M, et al. Intestinal apolipoprotein A-IV gene transcription is controlled by two hormone-responsive elements: a role for hepatic nuclear factor-4 isoforms. Mol Endocrinol. 2005;19:2320-34 pubmed
    ..The combination of multiple HREs may specifically recruit regulatory complexes associating HNF-4 and either coactivators in villi or corepressors in crypts. ..
  26. de Franca E, Silva D, Silva T, Dornelles C, Alves J, Alho C. APOA5 polymorphisms associated with lipid metabolism in Brazilian children and adolescents. Genet Mol Res. 2016;15: pubmed publisher
    ..In this study we aimed to determine the allelic and genotypic frequencies of -1131T>C, Ser19Trp, and intergenic APOA4/A5 and to evaluate the association between these variants with plasma lipid levels in children and adolescents ..
  27. Vowinkel T, Mori M, Krieglstein C, Russell J, Saijo F, Bharwani S, et al. Apolipoprotein A-IV inhibits experimental colitis. J Clin Invest. 2004;114:260-9 pubmed
    ..This anti-inflammatory effect likely involves the inhibition of P-selectin-mediated leukocyte and platelet adhesive interactions. ..
  28. Ejchel T, Araujo L, Ramos L, Cendoroglo M, de Arruda Cardoso Smith M. Association of the apolipoprotein A-IV: 360 Gln/His polymorphism with cerebrovascular disease, obesity, and depression in a Brazilian elderly population. Am J Med Genet B Neuropsychiatr Genet. 2005;135B:65-8 pubmed
    ..This is the first study analyzing this polymorphism in elderly people in Brazil. More studies should be encouraged to elucidate the mechanisms involved in these diseases. ..
  29. Timms J, Arslan Low E, Kabir M, Worthington J, Camuzeaux S, Sinclair J, et al. Discovery of serum biomarkers of ovarian cancer using complementary proteomic profiling strategies. Proteomics Clin Appl. 2014;8:982-93 pubmed publisher
    ..Both profiling platforms were complementary in identifying biomarker candidates, four of which (A1AT, SLPI, APOA4, VDBP) significantly discriminated malignant from benign cases...
  30. von Toerne C, Huth C, de Las Heras Gala T, Kronenberg F, Herder C, Koenig W, et al. MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study. Diabetologia. 2016;59:1882-92 pubmed publisher
  31. Bai H, Liu R, Liu Y, Liu B. [Analysis of apoA IV gene VNTR polymorphism in Chinese endogenous hypertriglyceridemics]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001;18:356-61 pubmed
    To search the variation of apoA IV gene and its relation to endogenous hypertriglyceridemia (HTG) in Chinese population...
  32. Weinberg R, Anderson R, Cook V, Emmanuel F, Denefle P, Tall A, et al. Interfacial exclusion pressure determines the ability of apolipoprotein A-IV truncation mutants to activate cholesterol ester transfer protein. J Biol Chem. 2002;277:21549-53 pubmed
  33. Crews D, Fitton L, Kottke B, Kamboh M. Population genetics of apolipoproteins A-IV, E, and H, and the angiotensin converting enzyme (ACE): associations with lipids, and apolipoprotein levels in American Samoans. Am J Phys Anthropol. 2004;124:364-72 pubmed
    ..The interaction term between ACE and APO E was also significantly associated with total-c and APO E levels, and the ACE genotype showed a significant main effect on APO AI levels in multivariate analyses. ..
  34. Broedl U, Schachinger V, Lingenhel A, Lehrke M, Stark R, Seibold F, et al. Apolipoprotein A-IV is an independent predictor of disease activity in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:391-7 pubmed
    ..435, 95% CI 0.995-11.853, P = 0.05). To our knowledge, this is the first study to demonstrate an association of apoA-IV with disease activity in patients with CD. Further studies are needed to define the relationship of apoA-IV to IBD. ..
  35. Yao Y, Lu S, Huang Y, Beeman Black C, Lu R, Pan X, et al. Regulation of microsomal triglyceride transfer protein by apolipoprotein A-IV in newborn swine intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011;300:G357-63 pubmed publisher
    ..Thus MTTP is regulated by apo A-IV in a manner to promote increased packaging of TG into the CM core, which may be important in neonatal fat absorption...
  36. Gombojav B, Lee S, Kho M, Song Y, Lee K, Sung J. Multiple susceptibility loci at chromosome 11q23.3 are associated with plasma triglyceride in East Asians. J Lipid Res. 2016;57:318-24 pubmed publisher
    ..06) clustered on 11q23.3: ApoA5 (rs651821, rs2075291); ZNF259 (rs964184, rs603446); BUD13 (rs11216126); Apoa4 (rs7396851); SIK3 (rs12292858); PCSK7 (rs199890178); PAFAH1B2 (rs12420127), and SIDT2 (rs2269399)...
  37. Massafra V, Milona A, Vos H, Burgering B, van Mil S. Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation. PLoS ONE. 2017;12:e0171185 pubmed publisher
    ..e., Tgfbi, Vcam1, Anxa2 and Hdlbp). Importantly, many of the FGF19 targets (i.e., Pdk4, Apoa4, Fas and Stat3) have a dual function in both metabolism and cell proliferation...
  38. Kovacevic L, Lu H, Caruso J, Govil Dalela T, Thomas R, Lakshmanan Y. Marked increase in urinary excretion of apolipoproteins in children with nephrolithiasis associated with hypercalciuria. Pediatr Nephrol. 2017;32:1029-1033 pubmed publisher
    ..Of those, 5 proteins (apolipoprotein A-II [APOA2]; apolipoprotein A-IV [APOA4]; apolipoprotein C-III [APOA3]; fatty acid-binding protein, liver [FABPL]; fatty acid-binding protein, adipocyte [..
  39. Zhang Y, Liu Z, Liu R, Wang J, Zheng M, Li Q, et al. Alteration of Hepatic Gene Expression along with the Inherited Phenotype of Acquired Fatty Liver in Chicken. Genes (Basel). 2018;9: pubmed publisher
    ..and glucose metabolism (ACACA, FASN, SCD, ACSL5, FADS2, FABP1, APOA4 and ME1). This study uniquely revealed that acquired fatty liver in cocks can be inherited...
  40. Duverger N, Murry Brelier A, Latta M, Reboul S, Castro G, Mayaux J, et al. Functional characterization of human recombinant apolipoprotein AIV produced in Escherichia coli. Eur J Biochem. 1991;201:373-83 pubmed
    ..It is concluded that the recombinant protein is functionally identical to the plasmatic apoAIV and may therefore be very useful in helping to elucidate the physiological role of apoAIV. ..
  41. Hubacek J, Bohuslavova R, Skodova Z, Pitha J, Bobkova D, Poledne R. Polymorphisms in the APOA1/C3/A4/A5 gene cluster and cholesterol responsiveness to dietary change. Clin Chem Lab Med. 2007;45:316-20 pubmed
    ..APOA1 (G-75>A and C83>T), APOC3 (C-482>T and C3238>G), APOA4 (Thr347>Ser and Gln360His) and APOA5 (T-1131>C, Ser19>Trp and Val153>Met) variants were analyzed by ..
  42. Canales A, Sanchez Muniz F, Bastida S, Librelotto J, Nus M, Corella D, et al. Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk. Eur J Clin Nutr. 2011;65:703-10 pubmed publisher
    Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms...
  43. Martínez Beamonte R, Navarro M, Acin S, Guillén N, Barranquero C, Arnal C, et al. Postprandial changes in high density lipoproteins in rats subjected to gavage administration of virgin olive oil. PLoS ONE. 2013;8:e55231 pubmed publisher
    ..Increased expression of intestinal Apoa1, Apoa4 and Sgms1 mRNA was accompanied by hepatic decreases in the first two genes in liver...
  44. Havel R, Kane J, Kashyap M. Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man. J Clin Invest. 1973;52:32-8 pubmed
  45. Gañán A, Corella D, Guillen M, Ordovas J, Pocovi M. Frequencies of apolipoprotein A4 gene polymorphisms and association with serum lipid concentrations in two healthy Spanish populations. Hum Biol. 2004;76:253-66 pubmed
    Apolipoprotein A4 (apoA4) plays a role in intestinal lipid absorption...
  46. Gao J, Wei Y, Huang Y, Liu D, Liu G, Wu M, et al. The expression of intact and mutant human apoAI/CIII/AIV/AV gene cluster in transgenic mice. J Biol Chem. 2005;280:12559-66 pubmed
  47. Pearson K, Tubb M, Tanaka M, Zhang X, Tso P, Weinberg R, et al. Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. J Biol Chem. 2005;280:38576-82 pubmed
    ..We propose a structural model in which these sequences can modulate the conformation and lipid affinity of apoA-IV. ..
  48. Gomaraschi M, Putt W, Pozzi S, Iametti S, Barbiroli A, Bonomi F, et al. Structure and function of the apoA-IV T347S and Q360H common variants. Biochem Biophys Res Commun. 2010;393:126-30 pubmed publisher
    ..The two common aminoacid substitutions have no effect on the ability of apoA-IV to maintain endothelial homeostasis. ..
  49. Wu Y, Yu Y, Zhao T, Wang S, Fu Y, Qi Y, et al. Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome. PLoS ONE. 2016;11:e0147946 pubmed publisher
    ..The APOA1/C3/A4/A5 gene cluster was associated with MetS in the Han Chinese. APOA5 rs662799 had interactions with the environmental factors associated with MetS. ..
  50. Lu X, Li J, Li H, Chen Y, Wang L, He M, et al. Coding-sequence variants are associated with blood lipid levels in 14,473 Chinese. Hum Mol Genet. 2016;25:4107-4116 pubmed publisher
    ..Arg93Cys, HMGCR p.Tyr311Ser, APOA5 p.Gly185Cys and CETP p.Asp399Gly) and two common (APOB p.Arg532Trp and APOA4 p.Ser147Asn) variants...
  51. Eaton S, Aiken A, Young P, Ho J, Cropley J, Suter C. Maternal obesity heritably perturbs offspring metabolism for three generations without serial programming. Int J Obes (Lond). 2017;: pubmed publisher
    ..Molecular analyses of male descendants identified upregulation of hepatic Apoa4 as a consistent signature of the latent phenotype across all generations...
  52. Luo J, Han L, Liu L, Gao L, Xue B, Wang Y, et al. Catechin supplemented in a FOS diet induces weight loss by altering cecal microbiota and gene expression of colonic epithelial cells. Food Funct. 2018;9:2962-2969 pubmed publisher
    ..in rats' cecum-and eight genes-including one downregulated Pla2g2a and seven upregulated genes: Apoa1, Apoa4, Aabr07073400...
  53. Patel A, Peloso G, Pirruccello J, Johansen C, Dubé J, Larach D, et al. Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution. Atherosclerosis. 2016;250:63-8 pubmed publisher
    ..Of these, one was a novel association: p.Ser147Asn variant in APOA4 (14.3% frequency, TG OR = 0.49, P = 7.1 × 10(-4)) with TG...
  54. Kretowski A, Hokanson J, McFann K, Kinney G, Snell Bergeon J, Maahs D, et al. The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes. Diabetologia. 2006;49:1946-54 pubmed
    ..The aim of the present study was to evaluate the association of apolipoprotein A-IV (APOA4) polymorphisms with coronary artery calcification (CAC) progression, a marker of subclinical atherosclerosis...
  55. Marques Vidal P, Bochud M, Paccaud F, Waterworth D, Bergmann S, Preisig M, et al. No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels. Atherosclerosis. 2010;211:551-7 pubmed publisher
    ..To assess the relationships and possible interactions between polymorphisms related to HDL levels and alcohol consumption...
  56. Hebiguchi T, Mezaki Y, Morii M, Watanabe R, Yoshikawa K, Miura M, et al. Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats. Int J Mol Med. 2015;35:724-30 pubmed publisher
    ..levels of cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than those in the sham-operated rats, as shown by RT-qPCR...
  57. Gupta A, Cole S, Labus J, Joshi S, Nguyen T, Kilpatrick L, et al. Gene expression profiles in peripheral blood mononuclear cells correlate with salience network activity in chronic visceral pain: A pilot study. Neurogastroenterol Motil. 2017;29: pubmed publisher
    ..genes (interleukin 6, APOL2) in IBS, but negatively correlated with several anti-inflammatory genes (KRT8, APOA4) in HCs...
  58. Moreira G, Boschiero C, Cesar A, Reecy J, Godoy T, Trevisoli P, et al. A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens. BMC Genomics. 2018;19:374 pubmed publisher
    ..that might regulate fat deposition in these QTL regions: JDP2, PLCG1, HNF4A, FITM2, ADIPOR1, PTPN11, MVK, APOA1, APOA4, APOA5, ENSGALG00000000477, ENSGALG00000000483, and ENSGALG00000005043...
  59. Qin W, Li X, Xie L, Li S, Liu J, Jia L, et al. A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice. Nucleic Acids Res. 2016;44:6423-33 pubmed publisher
    ..Here, we identified 15 lncRNAs, which are associated with fatty liver disease. Among them, APOA4-AS is shown to be a concordant regulator of Apolipoprotein A-IV (APOA4) expression...
  60. Zee R, Cook N, Cheng S, Erlich H, Lindpaintner K, Ridker P. Polymorphism in the beta2-adrenergic receptor and lipoprotein lipase genes as risk determinants for idiopathic venous thromboembolism: a multilocus, population-based, prospective genetic analysis. Circulation. 2006;113:2193-200 pubmed
    ..These present findings are hypothesis generating and require replication and confirmation in an independent investigation. ..
  61. Ghiselli G, Krishnan S, Beigel Y, Gotto A. Plasma metabolism of apolipoprotein A-IV in humans. J Lipid Res. 1986;27:813-27 pubmed
  62. Jones B, Jones E, Bonney S, Patel H, Mensenkamp A, Eichenbaum Voline S, et al. Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet. 2003;34:29-31 pubmed
    ..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell. ..
  63. Pollin T, Damcott C, Shen H, Ott S, Shelton J, Horenstein R, et al. A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science. 2008;322:1702-5 pubmed publisher
    ..Subclinical atherosclerosis, as measured by coronary artery calcification, was less common in carriers than noncarriers, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect. ..
  64. Lairon D, Defoort C, Martin J, Amiot Carlin M, Gastaldi M, Planells R. Nutrigenetics: links between genetic background and response to Mediterranean-type diets. Public Health Nutr. 2009;12:1601-6 pubmed publisher
    ..The data provided add further evidence of the interaction between particular SNP and metabolic responses to diets. Finally, improvement in dietary recommendations by taking into account known genetic variability has been discussed. ..
  65. Peters K, Davis W, Ito J, Winfield K, Stoll T, Bringans S, et al. Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II. Diabetes Care. 2017;40:1548-1555 pubmed publisher
    To assess the ability of plasma apolipoprotein (apo) A-IV (apoA4), apo C-III, CD5 antigen-like (CD5L), complement C1q subcomponent subunit B (C1QB), complement factor H-related protein 2, and insulin-like growth factor binding protein 3 (..
  66. Lohse P, Kindt M, Rader D, Brewer H. Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys). J Biol Chem. 1991;266:13513-8 pubmed
    ..These results indicate that one predominant allele codes for the isoproteins apoA-IV-2 and apoA-IV-0 and that at least two major allelic variants for the isoproteins apoA-IV-1 and apoA-IV-3 are present in the population analyzed. ..
  67. Islam M, Raitakari O, Juonala M, Kahonen M, Hutri Kähönen N, Collings A, et al. Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms and their association with carotid artery intima-media thickness in the Finnish population. The Cardiovascular Risk in Young Finns Study. Atherosclerosis. 2005;180:79-86 pubmed
    ..However, serum total and LDL cholesterol and apoB concentrations were significantly different among apoB genotype groups (p<0.001 for all traits). The apoA-I/C-III/A-IV SstI polymorphism is associated with carotid IMT in young Finns. ..
  68. Dasari S, Amin M, Kurtin P, Vrana J, Theis J, Grogg K, et al. Clinical, biopsy, and mass spectrometry characteristics of renal apolipoprotein A-IV amyloidosis. Kidney Int. 2016;90:658-64 pubmed publisher
    ..The diagnosis is best established by mass spectrometry. Hence, a high degree of suspicion and examination of the renal medulla is required to make the diagnosis. ..
  69. Wang Q, Liu M, Xu L, Wu Y, Huang Y. Transcriptome analysis reveals the molecular mechanism of hepatic fat metabolism disorder caused by Muscovy duck reovirus infection. Avian Pathol. 2018;47:127-139 pubmed publisher
    ..the expression of key enzymes involved in fatty acid degradation (scavenger receptor class b type 1, ABCG8, and APOA4), leading to the accumulation of fatty acids and cholesterol in the liver cells...
  70. Karathanasis S, Oettgen P, Haddad I, Antonarakis S. Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Proc Natl Acad Sci U S A. 1986;83:8457-61 pubmed
    ..coding for three proteins of the plasma lipid transport system--apolipoproteins A1 (APOA1), C3 (APOC3), and A4 (APOA4)--are closely linked and tandemly organized on the long arm of human chromosome 11...
  71. Geethanjali F, Luthra K, Lingenhel A, Kanagasaba Pathy A, Jacob J, Srivastava L, et al. Analysis of the apo(a) size polymorphism in Asian Indian populations: association with Lp(a) concentration and coronary heart disease. Atherosclerosis. 2003;169:121-30 pubmed
  72. Bai H, Liu R, Liu Y, Saku K, Liu B. Distribution and effect of apo A-IV genotype on plasma lipid and apolipoprotein levels in a Chinese population. Acta Cardiol. 2008;63:315-22 pubmed
    ..These results suggest that codon 9, Msp I and VNTR polymorphisms in the apo A-IV gene are associated with type-IV hyperlipoproteinaemia in a Chinese population. ..
  73. Guo X, Hao Y, Kamilijiang M, Hasimu A, Yuan J, Wu G, et al. Potential predictive plasma biomarkers for cervical cancer by 2D-DIGE proteomics and Ingenuity Pathway Analysis. Tumour Biol. 2015;36:1711-20 pubmed publisher
    ..that 10 plasma proteins as candidate biomarker were screened, mainly including lipid metabolism-related proteins (APOA4, APOA1, APOE), complement (EPPK1, CFHR1), metabolic enzymes (CP, F2, MASP2), glycoprotein (CLU), and immune ..
  74. Lu W, Cheng Y, Chen K, Wang H, Gerhard G, Still C, et al. Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels. Hum Mol Genet. 2015;24:2390-400 pubmed publisher
    ..locus on chromosome 6q25-26 and found Lp(a) levels also to be significantly associated with a SNP near the APOA5-APOA4-APOC3-APOA1 gene cluster on chromosome 11q23 linked in the Amish to the APOC3 R19X null mutation...
  75. de Jesus J, Galazzi R, de Lima T, Banzato C, de Almeida Lima E Silva L, de Rosalmeida Dantas C, et al. Simplifying the human serum proteome for discriminating patients with bipolar disorder of other psychiatry conditions. Clin Biochem. 2017;50:1118-1125 pubmed publisher
    ..From these spots detected, 13 different proteins were identified: ApoA1, ApoE, ApoC3, ApoA4, Samp, SerpinA1, TTR, IgK, Alb, VTN, TR, C4A and C4B...
  76. Van Aalst Cohen E, Jansen A, Boekholdt S, Tanck M, Fontecha M, Cheng S, et al. Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia. Eur J Hum Genet. 2005;13:1137-42 pubmed
  77. Gomez P, Perez Martinez P, Marin C, Camargo A, Yubero Serrano E, Garcia Rios A, et al. APOA1 and APOA4 gene polymorphisms influence the effects of dietary fat on LDL particle size and oxidation in healthy young adults. J Nutr. 2010;140:773-8 pubmed publisher
    We investigated whether APOA1 and APOA4 genotypes interact with diet to determine changes in LDL size and their susceptibility to oxidative modifications...
  78. Wu J, Guo Z, Gao Y. Dynamic changes of urine proteome in a Walker 256 tumor-bearing rat model. Cancer Med. 2017;6:2713-2722 pubmed publisher
    ..A total of 10 urinary proteins (HPT, APOA4, CO4, B2MG, A1AG, CATC, VCAM1, CALB1, CSPG4, and VTDB) changed significantly even before a tumor mass was palpable,..
  79. Wong W, Stephens J, Acharya J, Hurel S, Humphries S, Talmud P. The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease. J Lipid Res. 2004;45:1565-71 pubmed
    Apolipoprotein A-IV (apoA-IV) has been postulated to be antiatherogenic. Transgenic APOA4/Apoe-/- mice are protected against atherosclerosis, with plasma apoA-IV displaying antioxidant activity in vitro...
  80. Singh P, Singh M, Gaur S, Kaur T. The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype. Diab Vasc Dis Res. 2007;4:124-9 pubmed
    ..45) even after adjustment for confounders. The findings in the present study suggest that each unit of P1-S2-X1 in diabetes increases the risk of CHD by a factor of 1.37+/-0.307 (beta + SE), which is manifest in its multiplicative mode. ..
  81. Orso E, Moehle C, Boettcher A, Szakszon K, Werner T, Langmann T, et al. The satiety factor apolipoprotein A-IV modulates intestinal epithelial permeability through its interaction with alpha-catenin: implications for inflammatory bowel diseases. Horm Metab Res. 2007;39:601-11 pubmed
    ..ApoA-IV expression is significantly impaired in IBD mucosa, even in non-inflamed regions. ..
  82. Liu Y, Ordovas J, Gao G, Province M, Straka R, Tsai M, et al. Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study. Pharmacogenet Genomics. 2009;19:161-9 pubmed publisher
    ..The genetic variants at APOA1/C3/A4/A5 gene cluster may be useful markers to predict response of lipid-lowering therapy with fenofibrate. Further studies to replicate/confirm our findings are warranted. ..
  83. Pranavchand R, Reddy B. Quantitative trait loci at the 11q23.3 chromosomal region related to dyslipidemia in the population of Andhra Pradesh, India. Lipids Health Dis. 2017;16:116 pubmed publisher
    Given the characteristic atherogenic dyslipidemia of south Indian population and crucial role of APOA1, APOC3, APOA4 and APOA5 genes clustered in 11q23...
  84. Jiang T, Shi L, Chen J, Wei L, Li M, Hu Y, et al. Screening and identification of potential protein biomarkers for evaluating the efficacy of intensive therapy in pulmonary tuberculosis. Biochem Biophys Res Commun. 2018;503:2263-2270 pubmed publisher
    ..Significant differences in complement component C7 (CO7), apolipoprotein A-IV (APOA4), apolipoprotein C-II (APOC2), and angiotensinogen (ANGT) were found by ELISA validation...
  85. Bisgaier C, Sachdev O, Lee E, Williams K, Blum C, Glickman R. Effect of lecithin:cholesterol acyltransferase on distribution of apolipoprotein A-IV among lipoproteins of human plasma. J Lipid Res. 1987;28:693-703 pubmed
    ..ApoA-IV may bind to these "gaps," where the packing density of the phospholipid head groups is reduced. ..
  86. Gordon J, Bisgaier C, Sims H, Sachdev O, Glickman R, Strauss A. Biosynthesis of human preapolipoprotein A-IV. J Biol Chem. 1984;259:468-74 pubmed
  87. Singh P, Singh M, Kaur T, Grewal S. A novel haplotype in ApoAI-CIII-AIV gene region is detrimental to Northwest Indians with coronary heart disease. Int J Cardiol. 2008;130:e93-5 pubmed
    ..05), which exacerbates (OR 2.61, CI 1.23-5.92, P<0.01) after adjustment with the confounders. This exacerbating effect of P2-S2-X1 may umpire significant higher levels of TG, LDL/HDL ratio and lower levels of HDL in CHD patients. ..
  88. Culnan D, Cooney R, Stanley B, Lynch C. Apolipoprotein A-IV, a putative satiety/antiatherogenic factor, rises after gastric bypass. Obesity (Silver Spring). 2009;17:46-52 pubmed publisher
    ..6 +/- 0.5-fold increase in apolipoprotein A-IV (apo A-IV, gene designation: APOA4), a approximately 46-kDa glycoprotein synthesized mainly in the bypassed small bowel and liver after RYGBP...
  89. Kang M, Kim J, An H, Ko J. Human leucine zipper protein promotes hepatic steatosis via induction of apolipoprotein A-IV. FASEB J. 2017;31:2548-2561 pubmed publisher
    ..LZIP increased the expression of apolipoprotein A-IV (APOA4) mRNA...
  90. Pranavchand R, Kumar A, Reddy B. Genetic determinants of clinical heterogeneity of the coronary artery disease in the population of Hyderabad, India. Hum Genomics. 2017;11:3 pubmed publisher
    ..Three of these (rs17440396:G>A, rs6589566:A>G, and rs2849165:G>A) that belong to BUD13, ZPR1, and APOA5-APOA4 intergenic regions, respectively, were found to be associated across the anatomical categories of CAD...