APC2

Summary

Gene Symbol: APC2
Description: adenomatosis polyposis coli 2
Alias: APCL, adenomatous polyposis coli like, adenomatous polyposis coli protein 2
Species: human

Top Publications

  1. pmc Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation
    Karin G Wirth
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Genes Dev 18:88-98. 2004
  2. ncbi Human APC2 localization and allelic imbalance
    C R Jarrett
    The Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington, DC 20007, USA
    Cancer Res 61:7978-84. 2001
  3. ncbi Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor
    J H van Es
    Department of Immunology, University Hospital, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Curr Biol 9:105-8. 1999
  4. ncbi Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin
    H Nakagawa
    Department of Genetics, Osaka University Medical School, Suita City, Japan
    Cancer Res 58:5176-81. 1998
  5. pmc An architectural map of the anaphase-promoting complex
    Brian R Thornton
    Cancer Research Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94115, USA
    Genes Dev 20:449-60. 2006
  6. pmc A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila
    Rebecca L Webb
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 136:1283-93. 2009
  7. ncbi Interaction of ligament bundles and articular contacts for the simulation of passive knee flexion
    M Ozkan
    Institute of Biomedical Engineering of Boğaziçi University, Boğaziçi Universitesi 34342 Bebek, Istanbul
    Conf Proc IEEE Eng Med Biol Soc 2007:4297-300. 2007
  8. pmc Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo
    Graham J Buttrick
    Department of Zoology, University of Oxford, Oxford OX1 3PS, England, UK
    J Cell Biol 180:537-48. 2008
  9. doi Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint
    Barry E McGuinness
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Curr Biol 19:369-80. 2009
  10. pmc The anaphase promoting complex/cyclosome is required during development for modified cell cycles
    Helena Kashevsky
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:11217-22. 2002

Research Grants

Scientific Experts

  • Fakhraddin Naghibalhossaini
  • H Manner
  • Jacques Champier
  • A M Jubb
  • Jean Schneikert
  • Hiroki Yamanaka
  • Nicholas S Tolwinski
  • Dal Ho Kim
  • A Gratchev
  • Thomas M Attard
  • Brooke M McCartney
  • Mark Peifer
  • Stephen Byers
  • Nikola Pavletich
  • David Roberts
  • Gary Hayward
  • Anna Velcich
  • AMY M BEJSOVEC
  • YASMATH AHMED
  • Jan Michael Peters
  • David M Roberts
  • Meng Ning Zhou
  • Takafumi Shintani
  • Ziguo Zhang
  • Min Mo
  • Prakash Dube
  • John S Poulton
  • Ezgi Kunttas-Tatli
  • Kathryn Akong
  • Anne Schreiber
  • Paula C A da Fonseca
  • Melissa A Hayden
  • David Barford
  • Holger Stark
  • Krishan Kumar
  • H Nakagawa
  • Rebecca L Webb
  • Kim Nasmyth
  • Xiong Ying
  • Nicholas G Brown
  • Alicia R Shields
  • Jianming Gao
  • Petra van der Lelij
  • Robert J Yamulla
  • P Mokarram
  • Dan T Bergstralh
  • Eric G Kane
  • Alexandria Wise
  • Keita Aoki
  • Georg Petzold
  • Yukako Nishimura
  • Margaret T Fuller
  • Pascale Dupont
  • Yukiko M Yamashita
  • Fangyuan Zhouzheng
  • Sandra Zimmerman
  • Hyun Ho Hwang
  • Fengyi Du
  • Bettina A Buschhorn
  • Yashi Ahmed
  • Xiaojing Zhang
  • Eric H Kong
  • Ivan Bosanac
  • Tanja Kuczera
  • Edward P Morris
  • Masaharu Noda
  • Liang Lu
  • Mayu Inaba
  • Hsiang Wen
  • Sandra G Zimmerman
  • Jian Cao
  • B M McCartney
  • Andrew A Mercer
  • Stephen B Fleming
  • Hassan Brim
  • Pooneh Mokarram
  • Wouter K de Jong
  • Hassan Ashktorab
  • Mehdi Nouraie
  • Dongsheng Chen
  • Duane T Smoot
  • Barry E McGuinness
  • Meghan T Maher
  • Mashaal Dhir
  • Hassina Benchabane
  • Franz Herzog
  • Graham J Buttrick
  • A Sullivan
  • M Ozkan
  • P C Hsieh

Detail Information

Publications97

  1. pmc Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation
    Karin G Wirth
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Genes Dev 18:88-98. 2004
    ..5 (E6.5). To investigate the role of APC/C in quiescent cells, we conditionally inactivated the subunit Apc2 in mice...
  2. ncbi Human APC2 localization and allelic imbalance
    C R Jarrett
    The Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington, DC 20007, USA
    Cancer Res 61:7978-84. 2001
    A second adenomatous polyposis coli (APC)-like gene, APC2/APCL, was recently described and localized to chromosome 19. We have fine mapped APC2 to a small region of chromosome 19p13...
  3. ncbi Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor
    J H van Es
    Department of Immunology, University Hospital, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Curr Biol 9:105-8. 1999
    ..Here, we report the identification and genomic structure of APC homologues. Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP ..
  4. ncbi Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin
    H Nakagawa
    Department of Genetics, Osaka University Medical School, Suita City, Japan
    Cancer Res 58:5176-81. 1998
    We isolated a novel gene, APCL, that showed significant homology to the adenomatous polyposis coli (APC) tumor suppressor gene. This novel gene, located on chromosome 19p13...
  5. pmc An architectural map of the anaphase-promoting complex
    Brian R Thornton
    Cancer Research Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94115, USA
    Genes Dev 20:449-60. 2006
    ..Apc1, serves as a scaffold that associates independently with two separable subcomplexes, one that contains Apc2 (Cullin), Apc11 (RING), and Doc1/Apc10, and another that contains the three TPR subunits (Cdc27, Cdc16, and Cdc23)...
  6. pmc A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila
    Rebecca L Webb
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 136:1283-93. 2009
    ..Here we report that Drosophila syncytial embryos null for Apc2 display defects in the formation and extension of pseudocleavage furrows, which are cortical actin structures ..
  7. ncbi Interaction of ligament bundles and articular contacts for the simulation of passive knee flexion
    M Ozkan
    Institute of Biomedical Engineering of Boğaziçi University, Boğaziçi Universitesi 34342 Bebek, Istanbul
    Conf Proc IEEE Eng Med Biol Soc 2007:4297-300. 2007
    The purpose of this study is to investigate the effects of anterior bundle of ACL (aACL), anterior portion of PCL (aPCL), anterior and deep portions of MCL (aMCL, dMCL) and the tibio-femoral articular contacts on to passive knee motion...
  8. pmc Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo
    Graham J Buttrick
    Department of Zoology, University of Oxford, Oxford OX1 3PS, England, UK
    J Cell Biol 180:537-48. 2008
    ..3 kinase (Zw3) and for the cortical localizations of the adenomatosis polyposis coli (APC)-related protein APC2/E-APC and the MT + Tip protein EB1...
  9. doi Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint
    Barry E McGuinness
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Curr Biol 19:369-80. 2009
    ..Experimental approaches hitherto used to inactivate the SAC in oocytes suffer from a number of drawbacks...
  10. pmc The anaphase promoting complex/cyclosome is required during development for modified cell cycles
    Helena Kashevsky
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:11217-22. 2002
    ..We show mr encodes the APC2 subunit of the anaphase promoting complex/cyclosome...
  11. pmc APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex
    Z Tang
    Departments of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9041, USA
    Mol Biol Cell 12:3839-51. 2001
    ..In combination with Ubc4 or UbcH10, a heterodimeric complex of APC2 and APC11 is sufficient to catalyze the ubiquitination of human securin and cyclin B1...
  12. doi Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer
    P Mokarram
    Department of Biochemistry, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran
    Mol Biol Rep 40:3851-7. 2013
    ..the frequency of their methylation changes with the results of our previously reported K-ras gene mutation, APC2 and p16 methylation. MGMT methylation was examined in 92 tumor samples...
  13. doi [Effect of recombinant pEGFP-N3-APC vectors carrying various APC functional domains on the expression of beta-catenin in HT-29 cells]
    Liang Lu
    Department of Gastroenterology, Second Xiangya Hospital, Central South University, Changsha 430011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:140-5. 2010
    ..To explore the effect of recombinant pEGFP-N3-APC vectors carrying various APC functional domains on the expression of beta-catenin in human colorectal cancer cells HT-29...
  14. pmc Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1
    Bettina A Buschhorn
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Nat Struct Mol Biol 18:6-13. 2011
    ..We show that Doc1 interacts with Cdc27, Cdc16 and Apc1 and is located in the vicinity of the cullin-RING module Apc2-Apc11 in the inner cavity of the APC/C...
  15. doi MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression
    Xiong Ying
    Department of Gynecology, State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou 510060, People s Republic of China Electronic address
    Biomed Pharmacother 71:64-9. 2015
    ..Therefore, it was speculated that adenomatous polyposis coli 2 (APC2) could play important roles in activating the Wnt/β-catenin pathway...
  16. pmc FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest
    Hsiang Wen
    Department of Internal Medicine, Roy and Lucille A Carver College of Medicine, Iowa City, USA
    Cell Cycle 9:4506-17. 2010
    ..Immunoprecipitation experiments demonstrate that FBG1 and APC2 interact directly...
  17. ncbi Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia
    A M Jubb
    Department of Pathology, Genentech Inc, South San Francisco, CA, USA
    Oncogene 25:3445-57. 2006
    ..Tumour cell lines stably transfected with LEF1(DN) or APC2, or transiently transfected with short-interfering RNA (siRNA) against beta-catenin showed a significant ..
  18. pmc Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo
    Ezgi Kunttas-Tatli
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Genetics 190:1059-75. 2012
    ..the functional role of these molecular interactions by making targeted mutations in Drosophila melanogaster APC2 that disrupt phosphorylation and extended region interactions and deletion mutants missing the Armadillo binding ..
  19. pmc Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling
    Robert J Yamulla
    Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania 17604
    Genetics 197:1285-302. 2014
    ..Here we test these models by generating a Drosophila APC2 mutant lacking all β-catenin-binding 20Rs and performing functional studies in human colon cancer cell lines and ..
  20. pmc RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex
    Nicholas G Brown
    Department of Structural Biology
    Proc Natl Acad Sci U S A 112:5272-9. 2015
    ..On the opposite side of the APC, the dynamic catalytic core contains the cullin-like subunit APC2 and its RING partner APC11, which collaborates with the E2 UBCH10 (UBE2C) to ubiquitinate substrates...
  21. pmc SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs
    Petra van der Lelij
    IMP Research Institute of Molecular Pathology, Vienna, Austria
    EMBO J 33:2643-58. 2014
    ..introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC/C subunit APC2. SNW1 depletion causes cohesion defects predominantly by reducing sororin levels, which causes destabilisation of ..
  22. ncbi The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
    M Hart
    Onyx Pharmaceuticals 3031 Research Drive Richmond California 94806 USA
    Curr Biol 9:207-10. 1999
    ..In contrast, beta-TrCP2 did not associate with beta-catenin. We conclude that beta-TrCP is a component of an E3 ubiquitin ligase that is responsible for the targeted degradation of phosphorylated beta-catenin...
  23. doi Isolation and characterization of a cryptogein-like gene from drought and salt-treated Alternanthera philoxeroides roots
    Jianming Gao
    Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, P R China Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China
    Biotechnol Lett 36:2351-6. 2014
    ..A cryptogein-like gene of A. philoxeroides, designated as ApCL, was cloned...
  24. pmc ASPP: a new family of oncogenes and tumour suppressor genes
    A Sullivan
    Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
    Br J Cancer 96:196-200. 2007
    ..They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1)...
  25. ncbi Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene to mouse chromosome band 10B5-C2 by in situ hybridisation
    S M Bell
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds UK
    Cytogenet Cell Genet 86:81-2. 1999
  26. pmc Drosophila-Cdh1 (Rap/Fzr) a regulatory subunit of APC/C is required for synaptic morphology, synaptic transmission and locomotion
    Alexandria Wise
    Department of Biology, City College of New York, and the Graduate Center of CUNY, New York, NY 10031, United States Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY 10032, United States
    Int J Dev Neurosci 31:624-33. 2013
    ..2004). In the Drosophila peripheral nervous system (PNS), APC2, a ligase subunit of the APC/C complex has been shown to regulate synaptic bouton size and activity (van Roessel et ..
  27. pmc Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells
    Yukako Nishimura
    Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e41413. 2012
    ..By analyzing fluorescent EB3 dynamics with automated tracking, we found that RNAi treatments targeting p150(glued), APC2, spastin, EB1, Op18, or MARK2 blocked Rac1-mediated MT growth in lamellipodia...
  28. doi Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila
    Dongsheng Chen
    State Key Laboratory of Reproductive Biology and State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang, Beijing 100101, P R China
    Development 136:4133-42. 2009
    ..Finally we show that, in common with APC2, Eff is required for the ubiquitylation of Cyclin A, and overexpression of full-length Cyclin A accelerates the ..
  29. pmc Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 8:e68072. 2013
    ..We show here that colon cancer cell lines express also the paralog APC-like (APCL or APC2)...
  30. ncbi Determination of non-ionic polyethoxylated surfactants in wastewater and river water by mixed hemimicelle extraction and liquid chromatography-ion trap mass spectrometry
    Manuel Cantero
    Department of Analytical Chemistry, Facultad de Ciencias, Edificio Anexo Marie Curie, Campus de Rabanales, 14071 Cordoba, Spain
    J Chromatogr A 1067:161-70. 2005
    ..chromatography/atmospheric pressure chemical ionisation in positive mode, ion trap mass spectrometry (LC/(APCl+-IT)-MS) for the concentration, separation and quantitation of non-ionic surfactants has been investigated...
  31. ncbi Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: signals that distinguish the human carcinogen tamoxifen
    Jessica C M Pole
    Cancer Genomics Program, Department of Pathology, Hutchison MRC Research Centre, University of Cambridge, Cambridge CB2 2XZ, UK
    Toxicology 206:91-109. 2005
    ..its proliferative response in the endometrium included changes in retinoblastoma and c-myc binding proteins, the APCL, dihydrofolate reductase (DHFR) and E2F1 genes and other transcription factors...
  32. pmc APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation
    John S Poulton
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Development 140:4226-36. 2013
    ..Using fly embryos as a model, we investigated the role of APC proteins in CIN. Our findings suggest that APC2 loss leads to increased rates of chromosome segregation error...
  33. pmc The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells
    Alicia R Shields
    Department of Genetics, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Development 141:73-82. 2014
    ..Germline specific overexpression of Adenomatous Polyposis Coli 2 (APC2) rescued GSC loss in chic hypomorphs, suggesting an additive role of APC2 and F-actin in maintaining the adherens ..
  34. doi Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2
    Takafumi Shintani
    Division of Molecular Neurobiology, National Institute for Basic Biology, Okazaki 444 8787, Japan
    J Neurosci 32:6468-84. 2012
    Adenomatous polyposis coli 2 (APC2) is a family member of APC and mainly expressed in the nervous system. We previously reported that APC2 plays a critical role in axonal projection through the regulation of microtubule stability...
  35. doi Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila
    Pascale Dupont
    Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, CNRS UMR 7286, Aix Marseille Universite, Marseille, France
    Neurobiol Dis 47:237-47. 2012
    ..Similarly, overexpression of one Armadillo/β-Catenin destruction complex component (Axin, APC2 or Shaggy/GSK-3β) increases the lifespan of HD flies...
  36. doi Regulation of nuclear envelope dynamics via APC/C is necessary for the progression of semi-open mitosis in Schizosaccharomyces japonicus
    Keita Aoki
    Microbial Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka, 411 8540, Japan
    Genes Cells 18:733-52. 2013
    ..As a suppressor of apc2 mutant, a mutation of Oar2, which was a 3-oxoacyl-[acyl carrier protein] reductase, was obtained...
  37. pmc Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization
    David M Roberts
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 23:2041-56. 2012
    ..APC's proposed roles in the nucleus or in precisely localizing the destruction complex by generating a series of APC2 variants to which we added tags relocalizing otherwise wild-type APC to different cytoplasmic locations...
  38. pmc Discs large links spindle orientation to apical-basal polarity in Drosophila epithelia
    Dan T Bergstralh
    The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Curr Biol 23:1707-12. 2013
    ..Previous work has implicated the apical polarity factor aPKC, the junctional protein APC2, and basal integrins in epithelial spindle orientation, but the underlying mechanisms remain unclear...
  39. pmc Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II
    Sandra G Zimmerman
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Dev Biol 340:54-66. 2010
    ..To determine the consequences of complete loss of APC in a model epithelium, we generated APC2 APC1 double null clones in the Drosophila wing imaginal disc...
  40. doi The anaphase promoting complex is required for memory function in mice
    Tanja Kuczera
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Gottingen D 37077, Germany
    Learn Mem 18:49-57. 2011
    ..we addressed the role of APC/C in learning and memory function by generating mice that lack the essential subunit APC2 from excitatory neurons of the adult forebrain...
  41. doi Modulation of K11-linkage formation by variable loop residues within UbcH5A
    Ivan Bosanac
    Department of Structural Biology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    J Mol Biol 408:420-31. 2011
    ..This study provides direct evidence that the linkage specificity of E2 enzymes may be altered through active-site mutagenesis...
  42. doi APC2 plays an essential role in axonal projections through the regulation of microtubule stability
    Takafumi Shintani
    Division of Molecular Neurobiology, National Institute for Basic Biology, Okazaki 444 8787, Japan
    J Neurosci 29:11628-40. 2009
    ..Here, we examined the functional role of adenomatous polyposis coli-like molecule 2 (APC2) in the development of axonal projections by using the chick retinotectal topographic projection system...
  43. pmc Distinct high-profile methylated genes in colorectal cancer
    Pooneh Mokarram
    Department of Internal Medicine and Gastroenterology Research Center, Shiraz, Iran University of Medical Sciences, Tehran, Iran
    PLoS ONE 4:e7012. 2009
    ..We investigated the status of CAN gene methylation and CHD5 protein expression in African American CRC tissue microarrays (TMA) using immunohistochemical staining...
  44. pmc Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion
    Meghan T Maher
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 186:219-28. 2009
    ..We show that axin, APC2, GSK-3beta and N-terminally phosphorylated forms of beta-cat can localize to cell-cell contacts in a complex that ..
  45. ncbi Promoter methylation primarily occurs in tumor cells of patients with non-small cell lung cancer
    Wouter K de Jong
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Anticancer Res 29:363-9. 2009
    ....
  46. ncbi APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus
    H Nakagawa
    Biomedical Research Center and the Second Department of Surgery, Osaka University Medical School, Japan
    Cancer Res 60:101-5. 2000
    b>APCL, a central nervous system-specific sequence homologue of the adenomatous polyposis coli tumor suppressor, can regulate the cytoplasmic level of beta-catenin as the adenomatous polyposis coli tumor suppressor does, but its overall ..
  47. doi Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture
    Ziguo Zhang
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    J Mol Biol 397:1316-28. 2010
    ..into two distinct sub-complexes; a catalytic sub-complex including the cullin domain and RING finger subunits Apc2 and Apc11, respectively, and a tetratricopeptide repeat (TPR) sub-complex composed of the TPR subunits Cdc16, Cdc23 ..
  48. pmc Identification of the target proteins of rosiglitazone in 3T3-L1 adipocytes through proteomic analysis of cytosolic and secreted proteins
    Hyun Ho Hwang
    Department of Molecular Medicine, Kyungpook National University, Daegu, 700 422, Korea
    Mol Cells 31:239-46. 2011
    ..is the first to report on two potential target proteins of rosiglitazone, such as adenomatosis polyposis coli 2 (APC2), and eukaryotic translation initiation factor 5A-1 (eIF5A) related to apoptosis and cell division...
  49. doi Structural basis for the subunit assembly of the anaphase-promoting complex
    Anne Schreiber
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK
    Nature 470:227-32. 2011
    ..subunits (Apc1, Apc4 and Apc5), coordinate the juxtaposition of the catalytic and substrate recognition module (Apc2, Apc11 and Apc10 (also known as Doc1)), and TPR-phosphorylation sites, relative to co-activator, regulatory ..
  50. doi High frequency of genes' promoter methylation, but lack of BRAF V600E mutation among Iranian colorectal cancer patients
    Fakhraddin Naghibalhossaini
    Department of Biochemistry, Shiraz University of Medical Sciences, School of Medicine, Zand Street, Shiraz, Fars, Iran
    Pathol Oncol Res 17:819-25. 2011
    ..The aim of the present study was to evaluate the methylation status of three cancer-related genes, APC2, p14ARF, and ECAD in colorectal carcinogenesis and their association with the mutational status of BRAF and KRAS ..
  51. doi Cigarette smoke suppresses the ubiquitin-dependent degradation of OLC1
    Xiaojing Zhang
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China
    Biochem Biophys Res Commun 407:753-7. 2011
    ..However, upon introducing CSC the binding of OLC1 to the proteins CDC20, CDH1, and APC2 was impaired...
  52. pmc Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila
    Meng Ning Zhou
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Cell Sci 124:1589-600. 2011
    ..S2 cells, we have dissected the structural and functional requirements for the cortical localization of Drosophila APC2. Here, we show that both the Armadillo repeats and a novel C-terminal domain are necessary for the cortical ..
  53. ncbi The synergistic effect of aligned nanofibers and hyaluronic acid modification on endothelial cell behavior for vascular tissue engineering
    Fengyi Du
    The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China
    J Nanosci Nanotechnol 11:6718-25. 2011
    ..and morphology of human umbilical vein endothelial cells (HUVECs) showed that the HA-coating aligned PCL (HA-aPCL) nanofibrous scaffolds could highly promote attachment and guide HUVECs bipolar spread with the parallel aligned ..
  54. pmc Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor
    Paula C A da Fonseca
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Nature 470:274-8. 2011
    ..from Cdh1, Apc10--a core APC/C subunit previously implicated in substrate recognition--and the cullin domain of Apc2. Cdh1 and Apc10, identified from difference maps, create a co-receptor for the D-box following repositioning of ..
  55. doi Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex
    Min Mo
    Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand
    J Gen Virol 91:3010-5. 2010
    ..Following knockdown of APC1, the subunit linking APC11/APC2 to the rest of APC/C, PACR remained bound to APC2 but not to other, distal, subunits of the complex, suggesting ..
  56. pmc E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells
    Mayu Inaba
    Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e12473. 2010
    ..that E-cadherin is indeed required for polarizing GSCs toward the hub cells, an effect that may be mediated by Apc2. We also demonstrated that E-cadherin is required for the GSC centrosome orientation checkpoint, which prevents ..
  57. pmc Cortical actin dynamics facilitate early-stage centrosome separation
    Jian Cao
    Sinsheimer Laboratories, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Curr Biol 20:770-6. 2010
    ..Both Arp2/3- and Formin-mediated actin remodeling are required for separating the centrosome pairs before NEB. The Apc2-Armadillo complex appears to link cap expansion to centrosome separation...
  58. pmc Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11
    Min Mo
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9016, New Zealand
    Proc Natl Acad Sci U S A 106:19527-32. 2009
    ..APC consists of at least 12 subunits with the catalytic core formed by a scaffold protein, APC2, and a RING-H2 protein, APC11...
  59. pmc Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans
    Krishan Kumar
    Department of Medicine and Cancer Center, Howard University, Washington, District of Columbia 20060, USA
    Clin Cancer Res 15:1155-61. 2009
    ..Here, we carried out a molecular analysis of sporadic colorectal cancer tumors from AAs to investigate possible explanations for the observed disparities...
  60. ncbi Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development
    Yashi Ahmed
    HHMI Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 129:1751-62. 2002
    ..The two Drosophila homologs of APC (Apc1 and Apc2) appear to have predominantly different tissue distributions, different subcellular localizations and mutually ..
  61. ncbi Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations
    Kathryn Akong
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Dev Biol 250:71-90. 2002
    ..We found that both proteins are expressed in the brain. APC2 has a highly dynamic, asymmetric localization through the larval neuroblast cell cycle relative to known mediators ..
  62. ncbi Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs
    Kathryn Akong
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Dev Biol 250:91-100. 2002
    ..We addressed this by eliminating the function of both Drosophila APC genes simultaneously. We find that APC1 and APC2 play overlapping roles in regulating Wingless signaling in the embryonic epidermis and the imaginal discs...
  63. ncbi Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle
    David Morgan
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
    Hum Mol Genet 11:3345-50. 2002
    ..We now provide evidence that inversin interacts with the anaphase promoting complex protein Apc2. As expected of an Apc2 target, inversin possesses D-boxes and site-directed mutagenesis of the well-conserved D-..
  64. ncbi Comparison of separation conditions and ionization methods for the liquid chromatography-mass spectrometric determination of sulfonamides
    Dal Ho Kim
    Organic Analysis Laboratory, Division of Chemical Metrology and Materials Evaluation, Korea Research Institute of Standards and Science, Yusong, Daejon 305 600, Republic of Korea
    J Chromatogr A 984:153-8. 2003
    ..For the separation of sulfonamides, 0.05 M NH4Ac in 13-15% aqueous acetonitrile, APCl ionization was more effective than ESI with regard to separation efficiency and the detection sensitivity.
  65. ncbi TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1
    Hartmut C Vodermaier
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 13:1459-68. 2003
    ..The APC is a ubiquitin ligase composed of at least 11 subunits. The interaction of APC2 and APC11 with E2 enzymes is sufficient for ubiquitination reactions, but the functions of most other subunits are ..
  66. pmc The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit
    Arnaud Capron
    Institut de Biologie Moléculaire des Plantes du Centre National de la Recherche Scientifique, 67084 Strasbourg Cedex, France
    Plant Cell 15:2370-82. 2003
    ..gain more insight into the roles of the plant APC/C, we characterized at the molecular level one of its subunits, APC2, which is encoded by a single-copy gene in Arabidopsis...
  67. ncbi Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas
    Allison E Bonner
    Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus, OH 43210, USA
    Oncogene 23:1166-76. 2004
    ..genes differentially expressed in both lung adenomas and ACs versus normal lungs, including the tumor suppressor APC2 and the oncogene Ros 1...
  68. ncbi Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Nat Cell Biol 3:933-8. 2001
    ..Here, we report that the tumour suppressor homologue APC2 and its binding partner Armadillo both play roles in spindle anchoring during the syncytial mitoses of early ..
  69. ncbi Interaction of MCC2, a novel homologue of MCC tumor suppressor, with PDZ-domain Protein AIE-75
    S Ishikawa
    Institute for Genetic Medicine Hokkaido University, Division of Cancer Related Genes, 060 0815, Sapporo, Japan
    Gene 267:101-10. 2001
    ..The MCC2 gene is located on chromosome 19p13 in the vicinity of APCL gene, while MCC1 maps near to APC tumor suppressor gene...
  70. pmc Budding yeast RSI1/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit
    K M Kramer
    Division of Yeast Genetics, National Institute for Medical Research, London, UK
    EMBO J 17:498-506. 1998
    ..Here we describe a gene we have identified by this means, RSI1/APC2. Temperature-sensitive rsi1/apc2 mutants arrest in metaphase and are unable to degrade Clb2p, suggesting that Rsi1p/..
  71. ncbi Identification of a cullin homology region in a subunit of the anaphase-promoting complex
    H Yu
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Science 279:1219-22. 1998
    ..The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned...
  72. ncbi ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
    T Ohta
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill 27599, USA
    Mol Cell 3:535-41. 1999
    ..ROC1 and ROC2 commonly interact with all cullins while APC11 specifically interacts with APC2, a cullin-related APC subunit...
  73. pmc Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
    F Fagotto
    Division of Cell Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    J Cell Biol 145:741-56. 1999
    ..Coexpression of hemagglutinin-tagged Dishevelled (Dsh) revealed strong colocalization with Axin, suggesting that Dsh can interact with the Axin/APC/GSK3/beta-catenin complex, and may thus modulate its activity...
  74. pmc Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
    ..We discuss the implications of our results for Wg signaling, and suggest a role for dAPC2 as a mediator of Wg effects on the cytoskeleton. We also speculate on more general roles that APCs may play in cytoskeletal dynamics...
  75. ncbi The impact of renal dysfunction on aprotinin pharmacokinetics during cardiopulmonary bypass
    C J O'Connor
    Department of Anesthesiology, Rush Medical College, Rush Presbyterian St Lukes Medical Center, Chicago, Illinois 60612, USA
    Anesth Analg 89:1101-7. 1999
    ..We, therefore, determined the clearance (ApCl) and elimination half-life (T1/2) of aprotinin in 26 cardiac surgical patients with normal and abnormal renal ..
  76. ncbi EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue
    H Nakagawa
    Division of Clinical Genetics, Biomedical Research Center, Osaka University Medical School, Osaka 565 0871, Japan
    Oncogene 19:210-6. 2000
    b>APCL, a homologue of the adenomatous polyposis coli (APC) tumor suppressor, can deplete cytoplasmic beta-catenin like APC...
  77. pmc The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
    M Gmachl
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 97:8973-8. 2000
    ..These results suggest that APC11 and UBC4 catalyze the formation of isopeptide bonds in APC-mediated ubiquitination reactions...
  78. ncbi Expression of Apc2 during mouse development
    Hiroki Yamanaka
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo 663 8501, Japan
    Brain Res Gene Expr Patterns 1:107-14. 2002
    APC2 (previously known as APCL), a molecule closely related to the adenomatous polyposis coli (APC) tumor suppressor, can deplete cytoplasmic beta-catenin, like APC itself...
  79. pmc Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development
    Melissa A Hayden
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Dev Biol 305:358-76. 2007
    ..the first assessment of the role of APC proteins in brain development, simultaneously inactivating both APC1 and APC2 in clones of cells in the Drosophila larval optic lobe...
  80. ncbi Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex
    Yang Wang
    State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    J Biol Chem 282:17712-9. 2007
    ..It interacts with the APC/c through the APC2 or Cdc27 subunits and is ubiquitinated...
  81. pmc HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4
    Karen E Strunk
    UNC Lineberger Comprehensive Cancer Center and Department of Medicine, University of North Carolina School of Medicine, 102 Mason Farm Road, Chapel Hill, NC 27599, USA
    Cancer Res 67:6582-90. 2007
    ..Inhibition of an APC subunit (APC2) using short interfering RNA knockdown impaired s80(HER4) degradation...
  82. ncbi Familial adenomatous polyposis in children younger than age ten years: a multidisciplinary clinic experience
    Thomas M Attard
    University of Nebraska Medical Center, Omaha, Nebraska 68198 5160, USA
    Dis Colon Rectum 51:207-12. 2008
    ..We present our multidisciplinary clinic experience with familial adenomatous polyposis in children younger than age ten years at the time of presentation...
  83. doi Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen
    Hassina Benchabane
    Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Development 135:963-71. 2008
    ..Arm is targeted for proteolysis by the Axin/Adenomatous polyposis coli (Apc1 and Apc2)/Zeste-white 3 destruction complex, and Wg-dependent inactivation of destruction complex activity is crucial to ..
  84. ncbi The tissue effect of second generation argon plasma coagulation (VIO APC) in comparison to standard APC and Nd:YAG laser in vitro
    Hendrik Manner
    Department of Internal Medicine II, HSK Wiesbaden, Wiesbaden, Germany
    Acta Gastroenterol Belg 70:352-6. 2007
    ..The aim of this study was to evaluate the effect of 2nd generation argon plasma coagulation (VIO APC) with respect to the tissue destruction capacity, and to compare it with standard APC and Nd:YAG laser...
  85. pmc Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia
    Mashaal Dhir
    Department of Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
    J Gastrointest Surg 12:1745-53. 2008
    ..This study examined the role of epigenetic silencing of WNT signaling pathway genes in the pathogenesis of IBD-associated neoplasia...
  86. pmc Membrane bound axin is sufficient for Wingless signaling in Drosophila embryos
    Nicholas S Tolwinski
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genetics 181:1169-73. 2009
    ..Here I probe the requirement for nuclear localization of APC2 and Axin in the Wg signal transduction pathway during embryonic development of Drosophila melanogaster...
  87. ncbi p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway
    P C Hsieh
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
    Oncogene 26:4928-40. 2007
    ..In addition, DDA3 bound to the EB3 interacting partner adenomatous polyposis coli 2 (APC2), a homolog of the tumor suppressor APC, which is a component of the beta-catenin destruction complex...
  88. ncbi Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila
    Brooke M McCartney
    Department of Biological Sciences, Carnegie Mellon University, 4400 5th Avenue, Pittsburgh, PA 15213, USA
    Development 133:2407-18. 2006
    ..We isolated six new alleles of Drosophila APC2. Two resemble the truncation alleles found in human tumors and one is a protein null...
  89. ncbi The receptor for interleukin-17E is induced by Th2 cytokines in antigen-presenting cells
    A Gratchev
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Scand J Immunol 60:233-7. 2004
    ..Here, we show that human monocyte-derived Th2-skewed antigen-presenting cells (APC2) express membrane-bound and soluble forms of IL-17BR on the mRNA and protein level upon stimulation with IL-4, IL-..
  90. ncbi Identification of differentially expressed genes in human pineal parenchymal tumors by microarray analysis
    Jacques Champier
    INSERM U433, Faculté de médecine RTH Laennec, 69372, Lyon Cedex 08, France
    Acta Neuropathol 109:306-13. 2005
    ..aminopeptidase and teratocarcinoma-derived growth factor 3 were up-regulated in PPT and in MB, and adenomatous polyposis coli like was down-regulated only in PPT...
  91. ncbi The influence of 1-aminocyclopentane-1-carboxylic acid at position 2 or 3 of AVP and its analogues on their pharmacological properties
    Wioleta Kowalczyk
    Department of Chemistry, University of Gdansk, Sobieskiego 18, 80 952 Gdansk, Poland
    J Pept Sci 11:584-8. 2005
    ..On the other hand, the Apc2 modification resulted in compounds having differently modified activities (high antidiuretic potency, low and ..
  92. ncbi Depletion of anaphase-promoting complex or cyclosome (APC/C) subunit homolog APC1 or CDC27 of Trypanosoma brucei arrests the procyclic form in metaphase but the bloodstream form in anaphase
    Praveen Kumar
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    J Biol Chem 280:31783-91. 2005
    ..Seven core subunit homologs of APC/C (APC1, APC2, APC11, CDC16, CDC23, CDC27, and DOC1) were identified in the Trypanosoma brucei genome data base...
  93. ncbi Grafting of gelatin on electrospun poly(caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell Orientation
    Zuwei Ma
    Nanoscience and Nanotechnology Initiative, National University of Singapore
    Tissue Eng 11:1149-58. 2005
    ..Nonwoven PCL nanofibers (PCL NF) and aligned PCL nanofibers (APCL NF) were fabricated by electrospinning technology...
  94. ncbi Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C
    Prakash Dube
    Max Planck Institute for Biophysical Chemistry, Goettingen, Germany
    Mol Cell 20:867-79. 2005
    ..are ubiquitinated by E2 enzymes that interact with a hetero-dimer of the RING subunit Apc11 and the cullin Apc2. We have obtained three-dimensional (3D) models of human and Xenopus APC/C by angular reconstitution and random ..
  95. ncbi The cell cycle of early mammalian embryos: lessons from genetic mouse models
    Jérôme Artus
    Unite de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, Paris, France
    Cell Cycle 5:499-502. 2006
    ..Mad2, Bub3, Chk1, Atr), genes involved in ubiquitin and ubiquitin-like pathways (Uba3, Ubc9, Cul1, Cul3, Apc2, Apc10, Csn2) as well as genes the function of which had not been previously ascribed to cell cycle regulation (..
  96. pmc Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program
    Nathan P Gomes
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:601-12. 2006
    ..Thus, select genes within the p53 pathway bypass the requirement for P-TEFb and RNAP II phosphorylation to trigger a cellular response to inhibition of global mRNA synthesis...
  97. ncbi cDNA structure and in situ localization of the Aplysia californica pro-hormone convertase PC2
    T Ouimet
    Laboratory of Neurobiology, Clinical Research Institute of Montreal, Que, Canada
    FEBS Lett 330:343-6. 1993
    The complete cDNA structure of the Aplysia californica pro-protein and pro-hormone convertase PC2 (aPC2) was obtained from a cDNA library of the nervous system...

Research Grants7

  1. Genetic modulation of Wingless/Wnt signaling
    AMY M BEJSOVEC; Fiscal Year: 2012
    ..many important pathway components, such as Tcf, the transcription factor that activates Wnt target genes, and Apc2, a human tumor suppressor homolog that negatively regulates the Wnt pathway...
  2. A model system to study the tumor suppressor APC and its role in Wnt regulation.
    David Roberts; Fiscal Year: 2013
    ..For these experiments, I propose to use Drosophila APC2 as a model for human APC, as members of the Wnt pathway are highly conserved throughout evolution...
  3. IMMEDIATE-EARLY REGULATORY GENES OF CYTOMEGALOVIRUS
    Gary Hayward; Fiscal Year: 2007
    ..of post-transcriptional interactions of IE2 with four potential cell cycle regulatory proteins p21, JAB1, APC2 and MAD2; (II) continued exploration of the role of PML, DAXX, SUMO and the PODs at very early times in the nucleus,..
  4. Inactivation of the Muc2 gene and colorectal cancer
    Anna Velcich; Fiscal Year: 2005
    ..e. cdx2) are involved in tumor formation in the Muc2-/- mouse. 3) by utilizing mouse models already available (Apcl 638 and ITF-/- animals), we will directly test whether there is interaction between loss of Muc2 and mutation in ..
  5. APC TUMOR SUPPRESSOR PROTEIN IN DEVELOPMENT
    YASMATH AHMED; Fiscal Year: 2003
    ..to address APC function, and are characterizing two closely related Drosophila homologs of APC (D-APC1 and D-APC2)...
  6. Structural biology of SCFs and related ubiquitin Ligases
    Nikola Pavletich; Fiscal Year: 2005
    ..The APC (anaphase promoting complex) E3 has a central role in coordinating mitosis. Two APC subunits, Apc2 and Apc1 1, share limited homology to the Cul1-Rbx1 components of the SCF...
  7. APC2 AND BREAST CANCER
    Stephen Byers; Fiscal Year: 2002
    DESCRIPTION: (Applicant's Description) A second member of the APC tumor suppressor family (APC2) was recently identified in this and other laboratories...