APC

Summary

Gene Symbol: APC
Description: adenomatous polyposis coli
Alias: BTPS2, DP2, DP2.5, DP3, PPP1R46, adenomatosis polyposis coli tumor suppressor, adenomatous polyposis coli protein, deleted in polyposis 2.5, protein phosphatase 1, regulatory subunit 46
Species: human

Top Publications

  1. ncbi Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients
    H Nagase
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mutat 1:467-73. 1992
  2. ncbi APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase
    Yunyun Su
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Cell 32:652-61. 2008
  3. doi Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer
    Karim Bougatef
    Laboratory of Human Genetics, Immunology, and Pathology, Faculty of Sciences Tunis, University of Tunis, Campus Universitaire, El Manar I, Tunis 2092, Tunisia
    Cancer Genet Cytogenet 187:12-8. 2008
  4. ncbi Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin
    Eunjeong Seo
    The University of Seoul, 90 Jeonnong dong, Dongdaemun Gu, Seoul 130 743, Republic of Korea
    Biochem Biophys Res Commun 357:81-6. 2007
  5. ncbi Genotype-phenotype correlations as a guide in the management of familial adenomatous polyposis
    Mary H Nieuwenhuis
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Gastroenterol Hepatol 5:374-8. 2007
  6. ncbi Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    Takashi Watanabe
    Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Dev Cell 7:871-83. 2004
  7. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
  8. ncbi APC binds to the novel protein EB1
    L K Su
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 55:2972-7. 1995
  9. ncbi Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
  10. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993

Research Grants

  1. ADENOMATOUS POLYPOSIS COLI AND MITOSIS: A ROLE FOR CYTOPLASMIC DYNEIN
    Deanna Smith; Fiscal Year: 2002
  2. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2009
  3. TRANSFORMING FUNCTIONS OF MUTANT COLON CANCER ONCOGENES
    Sanford Markowitz; Fiscal Year: 1992
  4. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
  5. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
  6. TUMOR SUPPRESSION BY THE APC GENE
    Joanna Groden; Fiscal Year: 1999
  7. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 2001
  8. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 1999
  9. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 2000
  10. Validation and Extension of the PREMM Model for Inherited Colorectal Cancer
    Sapna Syngal; Fiscal Year: 2013

Detail Information

Publications254 found, 100 shown here

  1. ncbi Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients
    H Nagase
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mutat 1:467-73. 1992
    We report here the result of a screening for germ-line mutations in the adenomatous polyposis coli (APC) gene in 61 new familial adenomatous polyposis (FAP) patients as well as a summary of the results of 150 patients...
  2. ncbi APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase
    Yunyun Su
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Cell 32:652-61. 2008
    ..is highly vulnerable to protein phosphatase 2A (PP2A) and must be protected by the adenomatous polyposis coli (APC) tumor suppressor protein...
  3. doi Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer
    Karim Bougatef
    Laboratory of Human Genetics, Immunology, and Pathology, Faculty of Sciences Tunis, University of Tunis, Campus Universitaire, El Manar I, Tunis 2092, Tunisia
    Cancer Genet Cytogenet 187:12-8. 2008
    Sporadic colorectal tumorigenesis is caused by alterations in the Wnt (APC, CTNNB1) and Ras pathways. Our objective was to analyze the occurrence of these genetic alterations in relation to tumor and patient characteristics...
  4. ncbi Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin
    Eunjeong Seo
    The University of Seoul, 90 Jeonnong dong, Dongdaemun Gu, Seoul 130 743, Republic of Korea
    Biochem Biophys Res Commun 357:81-6. 2007
    It has been shown that accumulation of free beta-catenin leads to mobility shift of adenomatous polyposis coli (APC) protein and that Axin facilitates this process...
  5. ncbi Genotype-phenotype correlations as a guide in the management of familial adenomatous polyposis
    Mary H Nieuwenhuis
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Gastroenterol Hepatol 5:374-8. 2007
    ..Rectal cancer risk is eliminated by IPAA, but complication rate is higher than in IRA. Mutation analysis might predict severity of polyposis and be helpful in the surgical decision...
  6. ncbi Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    Takashi Watanabe
    Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Dev Cell 7:871-83. 2004
    ..Adenomatous polyposis coli (APC) is also thought to play a pivotal role in polarized cell migration...
  7. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
    ..Two genes on 5q21 that are tightly linked to FAP (MCC and APC) were found to be somatically altered in tumors from sporadic colorectal cancer patients...
  8. ncbi APC binds to the novel protein EB1
    L K Su
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 55:2972-7. 1995
    Mutations of the APC gene play a critical role in both sporadic and familial forms of colorectal cancer. The vast majority of these mutations result in the loss of the carboxyl terminus of the protein...
  9. ncbi Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
    Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors...
  10. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993
    Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product...
  11. doi Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer
    Kenichiro Saito
    Division of Translational and Clinical Oncology, Molecular and Cellular Targeting Translational Oncology Center, Cancer Research Institute, Kanazawa University, Japan
    Clin Cancer Res 16:2418-26. 2010
    ..The aim of this study was to evaluate the prognostic significance of both global hypomethylation and gene promoter hypermethylation in DNA from non-small cell lung cancer (NSCLC)...
  12. ncbi Identification of FAP locus genes from chromosome 5q21
    K W Kinzler
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 253:661-5. 1991
    ..Two of these genes (APC and MCC) are likely to contribute to colorectal tumorigenesis...
  13. pmc Role of APC and DNA mismatch repair genes in the development of colorectal cancers
    Satya Narayan
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, Academic Research Building, Room R4 216, 1600 SW Archer Road, University of Florida, Gainesville, FL 32610, USA
    Mol Cancer 2:41. 2003
    ..The FAP and HNPCC are caused due to mutations in the adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes...
  14. doi Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression
    Liyang Liu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Int J Cancer 129:2454-62. 2011
    ..We correlated quantitative promoter methylation levels of APC, TGFβ2 and RASSF1A in 219 radical prostatectomies diagnosed between 1998 and 2001 with clinicopathological follow-..
  15. ncbi Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 17:1978-87. 2008
    The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are beta-catenin-binding sites...
  16. pmc Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis
    Christopher Groves
    Academic Unit and Polyposis Registry, Saint Mark s Hospital, Harrow, United Kingdom
    Am J Pathol 160:2055-61. 2002
    Studies of adenomatous polyposis coli (APC) mutations in familial adenomatous polyposis (FAP) have focused on large bowel disease...
  17. ncbi Crystal structure of a beta-catenin/Tcf complex
    T A Graham
    Department of Biological Structure University of Washington 98195, Seattle, WA, USA
    Cell 103:885-96. 2000
    ..three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies...
  18. doi Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication
    Efstathios Kastritis
    Department of Clinical Therapeutics, Athens University, School of Medicine, Athens, Greece
    Int J Cancer 124:103-8. 2009
    ..We searched for mutations in adenomatous polyposis coli (APC), a key regulator of the pathway, and studied b-catenin expression and interactions with the expression of other ..
  19. pmc Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription
    Rina Rosin-Arbesfeld
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 22:1101-13. 2003
    The adenomatous polyposis coli (APC) protein is inactivated in most colorectal tumours. APC loss is an early event in tumorigenesis, and causes an increase of nuclear beta-catenin and its transcriptional activity...
  20. ncbi Characterization of functional domains of human EB1 family proteins
    Wen Bu
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:49721-31. 2003
    ..which include EB1, EBF3, and RP1, also associate with the tumor suppressor protein adenomatous polyposis coli (APC) and p150glued, a component of the dynactin complex...
  21. doi Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 18:213-26. 2009
    Biallelic mutation of the ADENOMATOUS POLYPOSIS COLI (APC) gene is a hallmark of sporadic colorectal cancer and colorectal, duodenal and desmoid tumours that develop in familial adenomatous polyposis (FAP) patients...
  22. ncbi Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients
    Lorenzo Richiardi
    Cancer Epidemiology Unit, University of Turin, Via Santena 7, 10126 Turin, Italy
    J Clin Oncol 27:3161-8. 2009
    ..and evaluated for promoter methylation status in glutathione S-transferase (GSTP1), adenomatous polyposis coli (APC), and runt-related transcription factor 3 (RUNX3)...
  23. pmc Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer
    Gillian Smith
    Cancer Research United Kingdom Molecular Pharmacology Unit, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 99:9433-8. 2002
    ..proposed in which the sequential accumulation of mutations in specific genes, including adenomatous polyposis coli (APC), Kirsten-ras (K-ras), and p53, drives the transition from healthy colonic epithelia through increasingly ..
  24. ncbi Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is responsible for both inherited and sporadic forms of colon cancer...
  25. ncbi Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor
    C L Day
    Department of Molecular and Cell Biology, University of California, 229 Stanley Hall 3206, Berkeley, CA, 94720 3206, USA
    J Mol Biol 301:147-56. 2000
    ..domains for a wide variety of proteins, including the medically important oligomeric tumor suppressor protein, APC. Mutations in the APC gene are associated with an inherited susceptibility to colon cancer and with approximately ..
  26. ncbi Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation
    J Zumbrunn
    School of Life Sciences, University of Dundee, Dundee, Scotland
    Curr Biol 11:44-9. 2001
    Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial polyposis, a form of inherited colon cancer...
  27. pmc Novel association of APC with intermediate filaments identified using a new versatile APC antibody
    Yang Wang
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
    BMC Cell Biol 10:75. 2009
    As a key player in suppression of colon tumorigenesis, Adenomatous Polyposis Coli (APC) has been widely studied to determine its cellular functions...
  28. doi Common variants in human CRC genes as low-risk alleles
    Simone Picelli
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Eur J Cancer 46:1041-8. 2010
    ..05-1.72), respectively (under the dominant model); while 2 SNPs, rs1800932:A>G (MSH6 P92P) and rs459552:T>A (APC D1822V) seemed to confer a protective effect. The latter, in particular showed an odds ratio of 0.76 (CI=0.60-0...
  29. doi Novel self-association of the APC molecule affects APC clusters and cell migration
    Zhuoyu Li
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, WTB MSI Complex, Dundee, UK
    J Cell Sci 121:1916-25. 2008
    Truncation mutations in the adenomatous polyposis coli (APC) gene are responsible for familial and sporadic colorectal cancer. APC is a multifunctional protein involved in cell migration, proliferation and differentiation...
  30. pmc Structural basis of the Axin-adenomatous polyposis coli interaction
    K E Spink
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    EMBO J 19:2270-9. 2000
    Axin and the adenomatous polyposis coli (APC) tumor suppressor protein are components of the Wnt/Wingless growth factor signaling pathway...
  31. ncbi Truncated APC is required for cell proliferation and DNA replication
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Int J Cancer 119:74-9. 2006
    The tumour suppressor APC is truncated in most colon cancers, which leads to the stabilization of beta-catenin and to the constitutive activation of Wnt signalling...
  32. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
    Most colorectal cancers have mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that stabilize beta-catenin and activate beta-catenin target genes, leading ultimately to cancer...
  33. pmc Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
    Ian P Newton
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Biol Cell 21:3630-8. 2010
    The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines the availability of β-catenin...
  34. ncbi Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
    Yi Xing
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    Mol Cell 15:523-33. 2004
    The tumor suppressor adenomatous polyposis coli (APC) plays a critical role in the turnover of cytosolic beta-catenin, the key effector of the canonical Wnt signaling pathway...
  35. ncbi The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF
    Fumihiko Hamada
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Dev Cell 7:677-85. 2004
    Adenomatous polyposis coli (APC) is an important tumor suppressor in the colon...
  36. ncbi The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase
    T Ishidate
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Oncogene 19:365-72. 2000
    The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in many sporadic colorectal tumors...
  37. ncbi Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 16:199-209. 2007
    Most colon cancer cells express truncated versions of the tumour suppressor Adenomatous Polyposis Coli (APC). These molecules are selected during tumourigenesis for impaired beta-catenin degrading activity...
  38. ncbi APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance
    Jan Sing Hsieh
    Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am Surg 71:336-43. 2005
    ..the sequential accumulation of mutations in specific cancer-related genes, including adenomatous polyposis coli (APC), K-ras, and p53, drives the transition from normal epithelium through increasing adenomatous dysplasia to ..
  39. doi APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas
    B Filipe
    Centro de Investigacao de Patobiologia Molecular CIPM, Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE IPOLFG, EPE, 1099 023 Lisboa, Portugal
    Clin Genet 76:242-55. 2009
    ..Overall, APC or MUTYH mutations were detected in 42/48 (88%), 14/20 (70%) and 10/38 (26%) of FAP, AFAP and MCRA patients, ..
  40. pmc The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history
    I M Frayling
    Colorectal Cancer Unit, Imperial Cancer Research Fund, St Mark s and Northwick Park Hospitals National Health Service Trust, Harrow, HA1 3UJ, United Kingdom
    Proc Natl Acad Sci U S A 95:10722-7. 1998
    ..to hundreds or thousands of colorectal adenomas and carcinoma and that results from truncating mutations in the APC gene...
  41. ncbi Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
    A Matsumine
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Japan
    Science 272:1020-3. 1996
    The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its product binds to the adherens junction protein beta-catenin...
  42. pmc Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001
    The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product beta-catenin. APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats...
  43. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
    We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients...
  44. pmc APC promoter methylation and protein expression in hepatocellular carcinoma
    Antal Csepregi
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Cancer Res Clin Oncol 134:579-89. 2008
    We investigated the impact of promoter methylation on APC protein expression in patients with hepatocellular carcinoma (HCC).
  45. ncbi Asef, a link between the tumor suppressor APC and G-protein signaling
    Y Kawasaki
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113, Japan
    Science 289:1194-7. 2000
    The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors...
  46. doi Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer
    Bo Bin Lee
    Molecular Cell Biology, Samsung Medical Center, Seoul, Korea
    Clin Cancer Res 15:6185-91. 2009
    ..To identify epigenetic molecular makers in plasma for the early detection of colorectal cancer...
  47. doi APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nu rnberg, Glu ckstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 20:3554-64. 2011
    The germline transmission of a mutation in the adenomatous polyposis coli (APC) gene leads to cancer of the gastro-intestinal tract upon somatic inactivation of the remaining allele in familial adenomatous polyposis (FAP) patients...
  48. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  49. doi Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas
    Xiangsheng Fu
    Institute for Digestive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Histopathology 55:554-63. 2009
    ..The aim of this study was to determine whether Wnt signalling plays a role in the pathogenesis of SAs, and to clarify the mechanism of Wnt signalling activation in SAs...
  50. pmc Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells
    V M Draviam
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    EMBO J 25:2814-27. 2006
    ..We find that RNAi-mediated depletion of two kMAPs, the adenomatous polyposis coli protein (APC) and its binding partner, EB1, are unusual in affecting the movement and orientation of paired ..
  51. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
    Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating beta-catenin turnover and localization...
  52. pmc A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  53. doi MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events
    S de Vogel
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Ann Oncol 20:1216-22. 2009
    ..in colorectal cancer (CRC), we investigated whether O6-methylguanine DNA methyltransferase (MGMT) and Human Mut-L Homologue 1 (MLH1) promoter hypermethylation are associated with APC, KRAS and BRAF mutations among 734 CRC patients.
  54. pmc The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
    Jose Sierra
    Regulatory Biology Laboratory, The Salk Insitute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:586-600. 2006
    The APC tumor suppressor controls the stability and nuclear export of beta-catenin (beta-cat), a transcriptional coactivator of LEF-1/TCF HMG proteins in the Wnt/Wg signaling pathway...
  55. ncbi Expression of the proliferating cell nuclear antigen and protein products of tumour suppressor genes in the human foetal testis
    S Maric
    Department of Biology, School of Medicine, University of Osijek, Osijek, Croatia
    Andrologia 36:24-30. 2004
    Tumour suppressor genes retinoblastoma (Rb1) and adenomatous polyposis coli (Apc) as well as the proliferating cell nuclear antigen (PCNA) are involved in embryonic development...
  56. pmc Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair
    Aimin Li
    Department of Pediatrics, Division of Neonatology, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, California 90033, USA
    Dev Dyn 239:2288-97. 2010
    Adenomatous polyposis coli (Apc) is critical for Wnt signaling and cell migration. The current study examined Apc expression during lung development, injury, and repair...
  57. ncbi Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
    Nam Chul Ha
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94043, USA
    Mol Cell 15:511-21. 2004
    ..occurs in a multiprotein complex that includes the kinases, beta-catenin, axin, and the Adenomatous Polyposis Coli (APC) protein. The role of APC in this process is poorly understood...
  58. ncbi Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15
    Li Kuo Su
    Department of Molecular and Cellular Oncology, Box 79, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030, USA
    Hum Genet 111:88-95. 2002
    Germline mutations of the adenomatous polyposis coli ( APC) gene cause familial adenomatous polyposis (FAP), an autosomal, dominantly inherited disease that predisposes patients to colorectal cancer...
  59. ncbi APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'
    Andrew Latchford
    Polyposis Registry, Cancer Research UK, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Hum Mol Genet 16:78-82. 2007
    Analysis of APC mutations in colonic and duodenal tumours from familial adenomatous polyposis (FAP) patients has shown that the site of the first hit, the germline mutation, can predict the type and position of the somatic mutation or '..
  60. pmc APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment
    Rebecca A Green
    Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
    Mol Biol Cell 16:4609-22. 2005
    Recently, we have shown that a cancer causing truncation in adenomatous polyposis coli (APC) (APC(1-1450)) dominantly interferes with mitotic spindle function, suggesting APC regulates microtubule dynamics during mitosis...
  61. pmc Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1
    Katsuhiro Kita
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 17:2331-45. 2006
    In interphase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subset of microtubules (MTs) in cell protrusions, suggesting that APC may regulate the dynamics of these MTs...
  62. ncbi Maternal mosaicism for a second mutational event--a novel deletion--in a familial adenomatous polyposis family harboring a new germ-line mutation in the alternatively spliced-exon 9 region of APC
    Sima Davidson
    Molecular Oncology Laboratory, Rambam Medical Center, Haifa, Israel
    Hum Mutat 19:83-4. 2002
    ..Familial Adenomatous Polyposis (FAP) is an autosomal dominant heritable disorder caused by germ-line mutations in the APC gene. To date, more than 300 germ-line mutations within this gene have been described...
  63. pmc Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein
    Zhenyi Zhang
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 6:e23507. 2011
    ..uses two of its three PDZ domains to interact with the C-terminal peptide of the Adenomatous Polyposis Coli (APC) tumor suppressor protein...
  64. ncbi Association analysis of Wnt pathway genes on prostate-specific antigen recurrence after radical prostatectomy
    Shu Pin Huang
    Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Ann Surg Oncol 17:312-22. 2010
    ..Although aberrant Wnt/beta-catenin (CTNNB1) signaling has been observed in numerous types of human cancers, including PCa, to our knowledge there is currently no information on the role of Wnt signaling gene polymorphisms in PCa...
  65. pmc Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells
    Hongmei Wang
    Department of Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute, Springfield, IL 62794 9677, United States
    Cancer Lett 272:253-9. 2008
    ..Both the CBS and Moser cells were found to express mutant (truncated) APC. Expression of this form of APC did not interfere with the tumor-suppressive function of TGFbeta...
  66. doi Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers
    Sebastien Gaujoux
    Institut Cochin, Université Paris Descartes Faculté de Médecine, CNRS UMR 8104, Paris, France
    Clin Cancer Res 16:5133-41. 2010
    ..ACT is observed in patients with familial adenomatous polyposis (FAP) with germline APC mutations, as well as in patients with Beckwith-Wiedemann syndrome with Wilms' tumors reported to have WTX somatic ..
  67. pmc A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation
    Shree Harsha Vijaya Chandra
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Glückstrasse, Erlangen, Germany
    PLoS ONE 7:e34479. 2012
    The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancer cases, leading to the synthesis of truncated APC products and the stabilization of β-catenin...
  68. doi Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients
    E M Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Bayern, Germany
    Oncogene 29:1663-71. 2010
    The adenomatous polyposis coli (APC) protein is a negative regulator of the mitogenic transcription factor beta-catenin by stimulating its proteasomal degradation...
  69. doi Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study
    B Rivera
    Centro de Investigaciones Biomédicas en Red de Enfermedades Raras CIBERER, Valencia, Spain
    Ann Oncol 22:903-9. 2011
    ..Classical familial adenomatous polyposis (FAP) is characterized by the appearance of >100 colorectal adenomas...
  70. ncbi IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:8545-56. 2007
    ..that beta-catenin co-localizes with IQ-domain GTPase-activating protein 1 (IQGAP1), adenomatous polyposis coli (APC), and N-cadherin at actin-positive membrane ruffles in NIH 3T3 fibroblasts...
  71. ncbi A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer
    M L Slattery
    Department of Family and Preventive Medicine University of Utah, Salt Lake City, 84112, USA
    Cancer Res 61:1000-4. 2001
    The adenomatous polyposis coli (APC) gene is important in the etiology of colon cancer. Although germ-line mutations of this gene rarely occur in the population, less penetrant variants of the gene have been reported...
  72. ncbi Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC
    Ursula Kurzik-Dumke
    Institute of Medical Microbiology and Hygiene, Laboratory for Comparative Tumor Biology, Johannes Gutenberg University, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Cell Signal 19:1973-85. 2007
    ..we provide evidence for the association of the endogenous Tid50/Tid48 proteins with the adenomatous polyposis coli (APC) tumor suppressor in normal colon epithelium, colorectal cancer cells and mouse NIH3T3 fibroblasts...
  73. ncbi Chemical dissection of the APC Repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3
    Anna Ferrarese
    Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy
    Biochemistry 46:11902-10. 2007
    ..in machinery controlled by Wnt signaling is the association of beta-catenin with the adenomatous polyposis coli (APC) protein, which is essential for the degradation of beta-catenin and requires the multiple phosphorylation of APC ..
  74. ncbi The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain
    K S Erdmann
    Department of Molecular Neurobiochemistry, Ruhr University Bochum, Germany
    Oncogene 19:3894-901. 2000
    Mutations of the tumor suppressor protein APC (Adenomatous Polyposis Coli) are linked to familiar and sporadic human colon cancer...
  75. ncbi Hot spots in beta-catenin for interactions with LEF-1, conductin and APC
    J P von Kries
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13093 Berlin, Germany
    Nat Struct Biol 7:800-7. 2000
    Interactions between beta-catenin and LEF-1/TCF, APC and conductin/axin are essential for wnt-controlled stabilization of beta-catenin and transcriptional activation...
  76. pmc The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis
    Jiang Qian
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210 2207, USA
    Gastroenterology 138:1418-28. 2010
    The adenomatous polyposis cell (APC) tumor suppressor is a multifunctional protein involved in cell migration, proliferation, differentiation, and apoptosis...
  77. ncbi Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
    J M Seeling
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
    Science 283:2089-91. 1999
    ..The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta form a Wnt-regulated signaling complex that mediates the ..
  78. pmc Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
    Dina Dikovskaya
    Division of Cell and Developmental Biology, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 176:183-95. 2007
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors...
  79. ncbi Identification of a link between the tumour suppressor APC and the kinesin superfamily
    Takeshi Jimbo
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 4:323-7. 2002
    The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours...
  80. ncbi Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability
    Anthony Tighe
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 117:6339-53. 2004
    ..cause chromosome instability remain undefined, mouse ES cells harbouring homozygous adenomatous polyposis coli (APC) mutations are frequently tetraploid...
  81. ncbi The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis
    H Lamlum
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Med 5:1071-5. 1999
    b>APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic mutations (or, infrequently, allelic loss) occur in tumors in FAP (familial adenomatous polyposis)...
  82. ncbi The molecular basis of Turcot's syndrome
    S R Hamilton
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2196
    N Engl J Med 332:839-47. 1995
    ..Turcot's syndrome is characterized clinically by the concurrence of a primary brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the molecular level...
  83. ncbi The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    A H Huber
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 105:391-402. 2001
    ..the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic ..
  84. ncbi [Methylation status and protein expression of adenomatous polyposis coli (APC) gene in breast cancer]
    Zhen Liu
    First Department of General Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, P R China
    Ai Zheng 26:586-90. 2007
    Protein expression product of adenomatous polyposis coli (APC) gene is an important component of Wnt signal transduction pathway...
  85. ncbi Familial adenomatous polyposis (FAP): genotype correlation to FAP phenotype with osteomas and sebaceous cysts
    Marie Luise Bisgaard
    Institute of Medical Biochemistry and Genetics, Department G, Copenhagen University, Panum Institute 24 4, Copenhagen N, Denmark
    Am J Med Genet A 140:200-4. 2006
    ..This disorder was regarded as a separate disease until the identification of the APC gene when it was recognized that mutations in the APC gene were the underlying cause of both Gardner syndrome and ..
  86. pmc The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase
    G H Baeg
    Department of Oncogene Research, Osaka University, Japan
    EMBO J 14:5618-25. 1995
    The APC gene is mutated in familial adenomatous polyposis (FAP) as well as in sporadic colorectal tumours. The product of the APC gene is a 300 kDa cytoplasmic protein associated with the adherence junction protein catenin...
  87. pmc Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability
    Karin Kroboth
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 18:910-8. 2007
    Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is involved in many processes that govern gut tissue...
  88. pmc Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation
    N J H Sturt
    Polyposis Registry, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Gut 53:1832-6. 2004
    ..FAP results from germline adenomatous polyposis coli (APC) gene mutations and desmoids arise following biallelic APC mutation, with one change usually occurring distal to ..
  89. ncbi Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
    T Nakamura
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Genes Cells 3:395-403. 1998
    ..The Wnt/Wingless signalling pathway plays an important role in both embryonic development and tumorigenesis. Beta-catenin and Axin are positive and negative effectors of the Wnt signalling pathway, respectively...
  90. ncbi Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma
    Brindusa Truta
    University California San Francisco, Department of Medicine, Comprehensive Cancer Center, San Francisco, California, USA
    Fam Cancer 2:95-9. 2003
    ..3%) unrelated patients with FAP associated thyroid cancers were identified. Adenomatous polyposis coli (APC) gene testing was performed in 14 of the 16 cases...
  91. ncbi Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP)
    Stefan Aretz
    Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany
    Hum Mutat 28:985-92. 2007
    ..During APC mutation screening in 1,248 unrelated patients with familial adenomatous polyposis (FAP), we identified 75 cases ..
  92. pmc Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC
    Rebecca A Green
    Section of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA
    J Cell Biol 163:949-61. 2003
    ..The mitotic abnormalities associated with CIN+ tumor cells correlated with status of adenomatous polyposis coli (APC)...
  93. ncbi Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis
    M Nielsen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Genet 71:427-33. 2007
    ..We aimed to assess the presence of germline mutations in the MUTYH and adenomatous polyposis coli (APC) genes in AFAP families and to compare the clinical features between the two causative genes...
  94. ncbi Dietary factors and the occurrence of truncating APC mutations in sporadic colon carcinomas: a Dutch population-based study
    Brenda Diergaarde
    Division of Human Nutrition and Epidemiology, Wageningen University, PO Box 8129, 6700 EV, Wageningen, The Netherlands
    Carcinogenesis 24:283-90. 2003
    ..associations between dietary factors and the occurrence of truncating mutations in the adenomatous polyposis coli (APC) gene in carcinomas...
  95. pmc Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects
    Jitka Stekrova
    Institute of Biology and Medical Genetics of the 1st Faculty of Medicine and General Teaching Hospital, Charles University, Albertov 4, Prague 2, 128 00, Czech Republic
    BMC Med Genet 8:16. 2007
    Germline mutations in the adenomatous polyposis gene (APC) result in familial adenomatous polyposis (FAP). FAP is an autosomal dominantly inherited disorder predisposing to colorectal cancer...
  96. ncbi A role for the Adenomatous Polyposis Coli protein in chromosome segregation
    K B Kaplan
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Cell Biol 3:429-32. 2001
    Mutations in the Adenomatous Polyposis Coli (APC) gene are responsible for familial colon cancer and also occur in the early stages of sporadic colon cancer...
  97. ncbi Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma
    Soichi Iwai
    Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Cancer Res Clin Oncol 131:773-82. 2005
    The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC, beta-catenin and Axin are mutated in some primary human cancers...
  98. ncbi Different combinations of biallelic APC mutation confer different growth advantages in colorectal tumours
    Jeremy P Cheadle
    Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Cancer Res 62:363-6. 2002
    ..Knudson's [corrected] "two-hit" hypothesis have been proposed recently in relation to adenomatous polyposis coli (APC): protein inactivation may be selected weakly, and the two hits may be interdependent...
  99. pmc Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients
    Markos Mihalatos
    Molecular Biology Research Center HYGEIA Antonis Papayiannist, Athens, Greece
    BMC Cancer 5:40. 2005
    Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene...
  100. pmc Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
    F Fagotto
    Division of Cell Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    J Cell Biol 145:741-56. 1999
    ..studies showed that Axin is part of a complex including these two proteins and adenomatous polyposis coli (APC). Here, we examine the role of different Axin domains in the effects on axis formation and beta-catenin levels...
  101. ncbi A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history
    Brindusa Truta
    Department of Medicine, Division of Gastroenterology and the Comprehensive Cancer Center, University of California San Francisco, 2330 Post Street, San Francisco, CA 94115 1623, USA
    Fam Cancer 4:127-33. 2005
    Adenomatous polyposis of the colon is often secondary to an inherited mutation in adenomatous polyposis coli (APC) gene, however, approximately one third of patients have no family history of the disease...

Research Grants77

  1. ADENOMATOUS POLYPOSIS COLI AND MITOSIS: A ROLE FOR CYTOPLASMIC DYNEIN
    Deanna Smith; Fiscal Year: 2002
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor protein are hallmarks of colorectal cancer. A large body of work has underscored APC's importance in regulating another protein, beta-catenin...
  2. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2009
    ..Its role in human cancer was first identified through the tumor suppressor Adenomatous polyposis coli (APC), mutated in most colon cancers. We now know that APC is a critical negative regulator of Wnt signaling...
  3. TRANSFORMING FUNCTIONS OF MUTANT COLON CANCER ONCOGENES
    Sanford Markowitz; Fiscal Year: 1992
    ..These genes are p53, K-ras, MCC, APC, and DCC...
  4. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
    ..Familial adenomatous polyposis coli (FAP) is an autosomal dominant disorder due to germline mutation of the APC gene and characterized by the formation of hundreds of colorectal adenomatous polyps in young adults...
  5. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
    Familial adenomatous polyposis coli (FAP) is an autosomal dominant disorder due to germline mutation of the APC gene and characterized by the formation of hundreds of colorectal adenomatous polyps in young adults...
  6. TUMOR SUPPRESSION BY THE APC GENE
    Joanna Groden; Fiscal Year: 1999
    ..One such genetic disorder is adenomatous polyposis coli or APC. We mapped and then isolated the APC gene by positional cloning from a region of chromosome 5q...
  7. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 2001
    ..from the investigator's abstract) The majority of colorectal cancers are associated with somatic mutations of the APC tumor suppressor gene...
  8. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 1999
    ..from the investigator's abstract) The majority of colorectal cancers are associated with somatic mutations of the APC tumor suppressor gene...
  9. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 2000
    ..from the investigator's abstract) The majority of colorectal cancers are associated with somatic mutations of the APC tumor suppressor gene...
  10. Validation and Extension of the PREMM Model for Inherited Colorectal Cancer
    Sapna Syngal; Fiscal Year: 2013
    ..JAMA 2012) which predicts the likelihood of an individual carrying a germline mutation in the APC and MYH genes, related to Familial Adenomatous Polyposis and MYH-Associated Polyposis...
  11. CHARACTERIZATION OF GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 1993
    ..Recently, we have identified two candidate tumor suppressor genes (APC and MCC) from the chromosome 5q2l region...
  12. CHARACTERIZATION OF GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 1992
    ..Recently, we have identified two candidate tumor suppressor genes (APC and MCC) from the chromosome 5q2l region...
  13. Proteomic Validation of the Min Mouse Model of Colon Cancer
    Anthony Yeung; Fiscal Year: 2006
    A Familial Adenomatous Polyposis' (FAR) patient has inherited a heterozygous mutation in the tumor suppressor gene APC (adenomatous polyposis coli) and will most likely develop colon cancer in his/her lifetime often because of loss of ..
  14. Proteomic Validation of the Min Mouse Model of Colon Cancer
    Anthony Yeung; Fiscal Year: 2007
    A Familial Adenomatous Polyposis' (FAR) patient has inherited a heterozygous mutation in the tumor suppressor gene APC (adenomatous polyposis coli) and will most likely develop colon cancer in his/her lifetime often because of loss of ..
  15. The role of stromal APC haploinsufficiency in colorectal tumorigenesis
    JAMES PETER ROBINSON; Fiscal Year: 2013
    ..FAP is caused by germline mutations in the Adenomatous Polyposis Coli (APC) gene. APC mutations are also found in sporadic colorectal adenomas and 85% of colon cancers carry APC mutations...
  16. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2000
    ..early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  17. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2001
    ..early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  18. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2002
    ..early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  19. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 1999
    ..early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  20. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 1999
    ..early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  21. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2003
    ..early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  22. Abrogating a survival pathway in early colon cancer cells
    Nan Gao; Fiscal Year: 2013
    ..90% hereditary and sporadic colorectal cancers are caused by initial mutation in the adenomatous polyposis coli (APC) gene...
  23. The pVHL/Jade-1/beta-catenin axis in renal cancer
    HERBERT TOD COHEN; Fiscal Year: 2013
    ..knockout mice and multiple intestinal neoplasia (Min) mice, which have a defect in the adenomatous polyposis coli (Apc) gene and have increased beta-catenin activity...
  24. The pVHL/Jade-1/beta-catenin axis in renal cancer
    HERBERT TOD COHEN; Fiscal Year: 2012
    ..knockout mice and multiple intestinal neoplasia (Min) mice, which have a defect in the adenomatous polyposis coli (Apc) gene and have increased beta-catenin activity...
  25. Novel resveratrol analogs and colorectal cancer treatment
    Chunming Liu; Fiscal Year: 2013
    ..CRC is initiated by mutations of adenomatous polyposis coli (APC) and b-catenin genes, which result in abnormal activation of the Wnt signaling pathway...
  26. A model system to study the tumor suppressor APC and its role in Wnt regulation.
    David Roberts; Fiscal Year: 2013
    ..Loss-of-function mutations in the tumor suppressor protein, Adenomatous Polyposis Coli (APC), inappropriately activate the pathway and frequently initiate cancer progression...
  27. Animal model of Gardner's syndrome, a life threatening form of familial cancer
    Yong Sik Bong; Fiscal Year: 2013
    ..FAP is an autosomal dominant disease caused by a mutation in the adenomatous polyposis coli (APC) tumor suppressor gene and is characterized by gastrointestinal polyps...
  28. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  29. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene Gerner; Fiscal Year: 2007
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  30. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene Gerner; Fiscal Year: 2009
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  31. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  32. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene Gerner; Fiscal Year: 2009
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  33. Radial Glial Development And Differentiation
    Eva S Anton; Fiscal Year: 2013
    ..Our preliminary results show that Adenomatous Polyposis Coli (APC) serves an essential function in the development of polarized radial glial scaffold during brain development...
  34. Radial Glial Development And Differentiation
    Eva S Anton; Fiscal Year: 2010
    ..Our preliminary results show that Adenomatous Polyposis Coli (APC) serves an essential function in the development of polarized radial glial scaffold during brain development...
  35. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 1999
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, little is known ..
  36. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2001
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, little is known ..
  37. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2000
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, little is known ..
  38. Tumor suppressor adenomatous polyposis coli and breast carcinogenesis
    Satya Narayan; Fiscal Year: 2007
    Our overall goal is to determine the role of the adenomatous polyposis coli (APC) gene in DNA damage-induced DNA repair activity and breast carcinogenesis...
  39. Tumor suppressor APC and breast carcinogenesis
    Satya Narayan; Fiscal Year: 2003
    Our overall goal is to determine the role of the adenomatous polyposis coli (APC) gene in DNA damage-induced DNA repair activity and breast carcinogenesis...
  40. Tumor suppressor APC and breast carcinogenesis.
    Satya Narayan; Fiscal Year: 2006
    Our overall goal is to determine the role of the adenomatous polyposis coli (APC) gene in DNA damage-induced DNA repair activity and breast carcinogenesis...
  41. Tumor suppressor APC and breast carcinogenesis.
    Satya Narayan; Fiscal Year: 2005
    Our overall goal is to determine the role of the adenomatous polyposis coli (APC) gene in DNA damage-induced DNA repair activity and breast carcinogenesis...
  42. Tumor suppressor APC and breast carcinogenesis.
    Satya Narayan; Fiscal Year: 2004
    Our overall goal is to determine the role of the adenomatous polyposis coli (APC) gene in DNA damage-induced DNA repair activity and breast carcinogenesis...
  43. MOLECULAR, CLINICAL APPROACHES COLON CANCER PRECURSORS
    Randall Burt; Fiscal Year: 2000
    ..has been provided by clinical and molecular genetic studies of the inherited syndrome, adenomatous polyposis coli (APC), and of sporadic colorectal polyps, thus providing one of the most important windows into the pathogenesis of ..
  44. MOLECULAR, CLINICAL APPROACHES COLON CANCER PRECURSORS
    Randall Burt; Fiscal Year: 2002
    ..has been provided by clinical and molecular genetic studies of the inherited syndrome, adenomatous polyposis coli (APC), and of sporadic colorectal polyps, thus providing one of the most important windows into the pathogenesis of ..
  45. MOLECULAR, CLINICAL APPROACHES COLON CANCER PRECURSORS
    Raymond White; Fiscal Year: 1999
    ..has been provided by clinical and molecular genetic studies of the inherited syndrome, adenomatous polyposis coli (APC), and of sporadic colorectal polyps, thus providing one of the most important windows into the pathogenesis of ..
  46. MOLECULAR, CLINICAL APPROACHES COLON CANCER PRECURSORS
    Randall Burt; Fiscal Year: 2001
    ..has been provided by clinical and molecular genetic studies of the inherited syndrome, adenomatous polyposis coli (APC), and of sporadic colorectal polyps, thus providing one of the most important windows into the pathogenesis of ..
  47. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2013
    ..Most cases are initiated by mutations in the tumor suppressor Adenomatous polyposis coli (APC)...
  48. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2004
    ..of the genetics of human colorectal cancer has led to the identification of the adenomatous polyposis cell (APC) gene as the putative "gatekeeper" of colorectal carcinogenesis...
  49. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2000
    ..of the genetics of human colorectal cancer has led to the identification of the adenomatous polyposis cell (APC) gene as the putative "gatekeeper" of colorectal carcinogenesis...
  50. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2002
    ..of the genetics of human colorectal cancer has led to the identification of the adenomatous polyposis cell (APC) gene as the putative "gatekeeper" of colorectal carcinogenesis...
  51. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2003
    ..of the genetics of human colorectal cancer has led to the identification of the adenomatous polyposis cell (APC) gene as the putative "gatekeeper" of colorectal carcinogenesis...
  52. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2001
    ..of the genetics of human colorectal cancer has led to the identification of the adenomatous polyposis cell (APC) gene as the putative "gatekeeper" of colorectal carcinogenesis...
  53. APC TUMOR SUPPRESSOR PROTEIN IN DEVELOPMENT
    YASMATH AHMED; Fiscal Year: 2002
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the majority of colorectal carcinomas...
  54. p120 and Kaiso dysregulation in intestinal tumorigenesis
    SARAH PALMER SHORT; Fiscal Year: 2013
    ..Loss of the tumor suppressor adenomatous polyposis coli (APC) gene is the initiating mutation in ~80% of these cancers and the driving mutation behind familial adenomatous ..
  55. Regulation of beta-catenin degradation during Wnt signal transduction
    Ethan Lee; Fiscal Year: 2013
    ..Since its identification two decades ago, however, the function of APC in Wnt signaling remains poorly understood...
  56. APC TUMOR SUPPRESSOR PROTEIN IN DEVELOPMENT
    YASMATH AHMED; Fiscal Year: 2001
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the majority of colorectal carcinomas...
  57. APC TUMOR SUPPRESSOR PROTEIN IN DEVELOPMENT
    YASMATH AHMED; Fiscal Year: 2003
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the majority of colorectal carcinomas...
  58. APC TUMOR SUPPRESSOR PROTEIN IN DEVELOPMENT
    YASMATH AHMED; Fiscal Year: 2000
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the majority of colorectal carcinomas...
  59. APC TUMOR SUPPRESSOR PROTEIN IN DEVELOPMENT
    YASMATH AHMED; Fiscal Year: 1999
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the majority of colorectal carcinomas...
  60. Mechanism of beta-catenin and APC-regulated transcription of Wnt target genes
    Katherine A Jones; Fiscal Year: 2010
    Most human colorectal cancer cells (CRC) contain mutations in the adenomatous polyposis coli (APC) tumor suppressor, which controls the stability of the transcriptional co-activator, beta-catenin (-cat)...
  61. Mechanism of beta-catenin and APC-regulated transcription of Wnt target genes
    Katherine Jones; Fiscal Year: 2009
    Most human colorectal cancer cells (CRC) contain mutations in the adenomatous polyposis coli (APC) tumor suppressor, which controls the stability of the transcriptional co-activator, beta-catenin (-cat)...
  62. Mechanism of beta-catenin and APC-regulated transcription of Wnt target genes
    Katherine Jones; Fiscal Year: 2007
    Most human colorectal cancer cells (CRC) contain mutations in the adenomatous polyposis coli (APC) tumor suppressor, which controls the stability of the transcriptional co-activator, beta-catenin (¿-cat)...
  63. Analysis of the Chemopreventive Activity of FGN 1
    MARGIE CLAPPER; Fiscal Year: 2001
    ..by decreasing both nuclear levels of beta-catenin and the transcriptional activation of downstream targets of the APC/beta-catenin pathway...
  64. APC Tumor Suppressor in Cell Differentiation and Death
    YASMATH AHMED; Fiscal Year: 2007
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the vast majority of colorectal carcinomas...
  65. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2010
    ..Its role in human cancer was first identified through the tumor suppressor Adenomatous polyposis coli (APC), mutated in most colon cancers. We now know that APC is a critical negative regulator of Wnt signaling...
  66. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2009
    ..Its role in human cancer was first identified through the tumor suppressor Adenomatous polyposis coli (APC), mutated in most colon cancers. We now know that APC is a critical negative regulator of Wnt signaling...
  67. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2002
    ..and organization are important in neurite outgrowth, and cadherins and the protein adenomatous polyposis coli (APC) are well placed to play key roles in coordinating these changes...
  68. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ..and organization are important in neurite outgrowth, and cadherins and the protein adenomatous polyposis coli (APC) are well placed to play key roles in coordinating these changes...
  69. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2004
    ..and organization are important in neurite outgrowth, and cadherins and the protein adenomatous polyposis coli (APC) are well placed to play key roles in coordinating these changes...
  70. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2003
    ..and organization are important in neurite outgrowth, and cadherins and the protein adenomatous polyposis coli (APC) are well placed to play key roles in coordinating these changes...
  71. Regulation of Cell Migration by the APC-Microtubule Complex
    W Nelson; Fiscal Year: 2006
    ..This proposal focuses on the role of the adenomatous polyposis coli (APC) multi- protein complex in regulating microtubule and actin cytoskeletons in response to extracellular signals that ..
  72. Analysis of the Chemopreventive Activity of FGN 1
    MARGIE CLAPPER; Fiscal Year: 2004
    ..by decreasing both nuclear levels of beta-catenin and the transcriptional activation of downstream targets of the APC/beta-catenin pathway...
  73. DETECTION OF ALTERED APC PROTEINS IN COLON CANCER CELLS
    David Hill; Fiscal Year: 1993
    Mutations in the APC gene appear to be crucial for adenoma formation in inherited Familial Adenomatous Polyposis (FAP) and in the early stages of colorectal cancer...
  74. Analysis of the Chemopreventive Activity of FGN 1
    MARGIE CLAPPER; Fiscal Year: 2003
    ..by decreasing both nuclear levels of beta-catenin and the transcriptional activation of downstream targets of the APC/beta-catenin pathway...
  75. APC Tumor Suppressor in Cell Differentiation and Death
    YASMATH AHMED; Fiscal Year: 2006
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the vast majority of colorectal carcinomas...
  76. GENES CONTROLLING NEOPLASIA OF THE INTESTINAL EPITHELIUM
    William Dove; Fiscal Year: 2007
    ..in the Min mouse strain have highlighted two new pathways by which the activity of the tumor suppressor gene Apc is lost: homologous somatic recombination and apparent epigenetic silencing...