APC

Summary

Gene Symbol: APC
Description: adenomatous polyposis coli
Alias: BTPS2, DP2, DP2.5, DP3, PPP1R46, adenomatosis polyposis coli tumor suppressor, deleted in polyposis 2.5, protein phosphatase 1, regulatory subunit 46, truncated adenomatosis polyposis coli
Species: human

Top Publications

  1. doi APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase
    Yunyun Su
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Cell 32:652-61. 2008
  2. doi Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer
    Karim Bougatef
    Laboratory of Human Genetics, Immunology, and Pathology, Faculty of Sciences Tunis, University of Tunis, Campus Universitaire, El Manar I, Tunis 2092, Tunisia
    Cancer Genet Cytogenet 187:12-8. 2008
  3. ncbi Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin
    Eunjeong Seo
    The University of Seoul, 90 Jeonnong dong, Dongdaemun Gu, Seoul 130 743, Republic of Korea
    Biochem Biophys Res Commun 357:81-6. 2007
  4. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
  5. pmc Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
    Ian P Newton
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Biol Cell 21:3630-8. 2010
  6. pmc Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity
    Alexander J Valvezan
    Cell and Molecular Biology Graduate Group, The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:3823-32. 2012
  7. doi An EB1-binding motif acts as a microtubule tip localization signal
    Srinivas Honnappa
    Biomolecular Research, Structural Biology, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland
    Cell 138:366-76. 2009
  8. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993
  9. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
  10. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992

Detail Information

Publications287 found, 100 shown here

  1. doi APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase
    Yunyun Su
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Cell 32:652-61. 2008
    ..is highly vulnerable to protein phosphatase 2A (PP2A) and must be protected by the adenomatous polyposis coli (APC) tumor suppressor protein...
  2. doi Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer
    Karim Bougatef
    Laboratory of Human Genetics, Immunology, and Pathology, Faculty of Sciences Tunis, University of Tunis, Campus Universitaire, El Manar I, Tunis 2092, Tunisia
    Cancer Genet Cytogenet 187:12-8. 2008
    Sporadic colorectal tumorigenesis is caused by alterations in the Wnt (APC, CTNNB1) and Ras pathways. Our objective was to analyze the occurrence of these genetic alterations in relation to tumor and patient characteristics...
  3. ncbi Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin
    Eunjeong Seo
    The University of Seoul, 90 Jeonnong dong, Dongdaemun Gu, Seoul 130 743, Republic of Korea
    Biochem Biophys Res Commun 357:81-6. 2007
    It has been shown that accumulation of free beta-catenin leads to mobility shift of adenomatous polyposis coli (APC) protein and that Axin facilitates this process...
  4. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
    Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating beta-catenin turnover and localization...
  5. pmc Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
    Ian P Newton
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Biol Cell 21:3630-8. 2010
    The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines the availability of β-catenin...
  6. pmc Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity
    Alexander J Valvezan
    Cell and Molecular Biology Graduate Group, The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:3823-32. 2012
    ..As Adenomatous Polyposis Coli (APC) functions in many of the same processes, we investigated a role for APC in the regulation of GSK-3-dependent ..
  7. doi An EB1-binding motif acts as a microtubule tip localization signal
    Srinivas Honnappa
    Biomolecular Research, Structural Biology, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland
    Cell 138:366-76. 2009
    ..that a short polypeptide motif, Ser-x-Ile-Pro (SxIP), is used by numerous +TIPs, including the tumor suppressor APC, the transmembrane protein STIM1, and the kinesin MCAK, for localization to microtubule tips in an EB1-dependent ..
  8. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993
    Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product...
  9. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
    Most colorectal cancers have mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that stabilize beta-catenin and activate beta-catenin target genes, leading ultimately to cancer...
  10. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
    We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients...
  11. pmc Role of APC and DNA mismatch repair genes in the development of colorectal cancers
    Satya Narayan
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, Academic Research Building, Room R4 216, 1600 SW Archer Road, University of Florida, Gainesville, FL 32610, USA
    Mol Cancer 2:41. 2003
    ..The FAP and HNPCC are caused due to mutations in the adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes...
  12. doi Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer
    Kenichiro Saito
    Division of Translational and Clinical Oncology, Molecular and Cellular Targeting Translational Oncology Center, Cancer Research Institute, Kanazawa University, Japan
    Clin Cancer Res 16:2418-26. 2010
    ..The aim of this study was to evaluate the prognostic significance of both global hypomethylation and gene promoter hypermethylation in DNA from non-small cell lung cancer (NSCLC)...
  13. ncbi Identification of FAP locus genes from chromosome 5q21
    K W Kinzler
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 253:661-5. 1991
    ..Two of these genes (APC and MCC) are likely to contribute to colorectal tumorigenesis...
  14. pmc Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex
    Hoanh Tran
    Department of Cancer Targets, Genentech Inc, South San Francisco, California 94080, USA
    J Biol Chem 287:28552-63. 2012
    The adenomatous polyposis coli (APC) tumor suppressor forms a complex with Axin and GSK3β to promote the phosphorylation and degradation of β-catenin, a key co-activator of Wnt-induced transcription...
  15. ncbi Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma
    Soichi Iwai
    Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Cancer Res Clin Oncol 131:773-82. 2005
    The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC, beta-catenin and Axin are mutated in some primary human cancers...
  16. ncbi High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients
    Rui Henrique
    Department of Pathology, Portuguese Oncology Institute Porto, Portugal
    Clin Cancer Res 13:6122-9. 2007
    ....
  17. pmc Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon
    Christine B Anderson
    Eccles Institute of Human Genetics and Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 99:8683-8. 2002
    Mutations in the APC tumor suppressor gene are present in approximately 85% of colorectal tumors and are thought to contribute early in the process of tumorigenesis...
  18. pmc Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis
    Christopher Groves
    Academic Unit and Polyposis Registry, Saint Mark s Hospital, Harrow, United Kingdom
    Am J Pathol 160:2055-61. 2002
    Studies of adenomatous polyposis coli (APC) mutations in familial adenomatous polyposis (FAP) have focused on large bowel disease...
  19. doi Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression
    Liyang Liu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Int J Cancer 129:2454-62. 2011
    ..We correlated quantitative promoter methylation levels of APC, TGFβ2 and RASSF1A in 219 radical prostatectomies diagnosed between 1998 and 2001 with clinicopathological follow-..
  20. doi Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 18:213-26. 2009
    Biallelic mutation of the ADENOMATOUS POLYPOSIS COLI (APC) gene is a hallmark of sporadic colorectal cancer and colorectal, duodenal and desmoid tumours that develop in familial adenomatous polyposis (FAP) patients...
  21. ncbi Characterization of functional domains of human EB1 family proteins
    Wen Bu
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:49721-31. 2003
    ..which include EB1, EBF3, and RP1, also associate with the tumor suppressor protein adenomatous polyposis coli (APC) and p150glued, a component of the dynactin complex...
  22. pmc Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription
    Rina Rosin-Arbesfeld
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 22:1101-13. 2003
    The adenomatous polyposis coli (APC) protein is inactivated in most colorectal tumours. APC loss is an early event in tumorigenesis, and causes an increase of nuclear beta-catenin and its transcriptional activity...
  23. pmc Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer
    Gillian Smith
    Cancer Research United Kingdom Molecular Pharmacology Unit, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 99:9433-8. 2002
    ..proposed in which the sequential accumulation of mutations in specific genes, including adenomatous polyposis coli (APC), Kirsten-ras (K-ras), and p53, drives the transition from healthy colonic epithelia through increasingly ..
  24. ncbi Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity
    Hee Jung Choi
    Department of Structural Biology, Stanford University School of Medicine, CA 94305 5126, USA
    J Biol Chem 281:1027-38. 2006
    ..beta-catenin is present in a multiprotein complex containing the proteins axin and adenomatous polyposis coli (APC), both of which bind directly to beta-catenin...
  25. doi Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients
    Lorenzo Richiardi
    Cancer Epidemiology Unit, University of Turin, Via Santena 7, 10126 Turin, Italy
    J Clin Oncol 27:3161-8. 2009
    ..and evaluated for promoter methylation status in glutathione S-transferase (GSTP1), adenomatous polyposis coli (APC), and runt-related transcription factor 3 (RUNX3)...
  26. ncbi Identification of a link between the tumour suppressor APC and the kinesin superfamily
    Takeshi Jimbo
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 4:323-7. 2002
    The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours...
  27. pmc Novel association of APC with intermediate filaments identified using a new versatile APC antibody
    Yang Wang
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
    BMC Cell Biol 10:75. 2009
    As a key player in suppression of colon tumorigenesis, Adenomatous Polyposis Coli (APC) has been widely studied to determine its cellular functions...
  28. pmc Structural basis of the Axin-adenomatous polyposis coli interaction
    K E Spink
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    EMBO J 19:2270-9. 2000
    Axin and the adenomatous polyposis coli (APC) tumor suppressor protein are components of the Wnt/Wingless growth factor signaling pathway...
  29. ncbi Truncated APC is required for cell proliferation and DNA replication
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Int J Cancer 119:74-9. 2006
    The tumour suppressor APC is truncated in most colon cancers, which leads to the stabilization of beta-catenin and to the constitutive activation of Wnt signalling...
  30. doi Novel self-association of the APC molecule affects APC clusters and cell migration
    Zhuoyu Li
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, WTB MSI Complex, Dundee, UK
    J Cell Sci 121:1916-25. 2008
    Truncation mutations in the adenomatous polyposis coli (APC) gene are responsible for familial and sporadic colorectal cancer. APC is a multifunctional protein involved in cell migration, proliferation and differentiation...
  31. ncbi The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF
    Fumihiko Hamada
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Dev Cell 7:677-85. 2004
    Adenomatous polyposis coli (APC) is an important tumor suppressor in the colon...
  32. ncbi The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase
    T Ishidate
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Oncogene 19:365-72. 2000
    The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in many sporadic colorectal tumors...
  33. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..This pathway is Siah2 and APC dependent, but GSK-3 and beta-TrCP independent...
  34. pmc Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
    F Fagotto
    Division of Cell Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    J Cell Biol 145:741-56. 1999
    ..studies showed that Axin is part of a complex including these two proteins and adenomatous polyposis coli (APC). Here, we examine the role of different Axin domains in the effects on axis formation and beta-catenin levels...
  35. ncbi Quantitative, spatial resolution of the epigenetic field effect in prostate cancer
    Jyoti Mehrotra
    Veridex LLC, a Johnson and Johnson Company, Warren, New Jersey, USA
    Prostate 68:152-60. 2008
    ..We tested this hypothesis using molecular techniques to detect epigenetic changes in the primary tumor and surrounding tissues...
  36. ncbi Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 16:199-209. 2007
    Most colon cancer cells express truncated versions of the tumour suppressor Adenomatous Polyposis Coli (APC). These molecules are selected during tumourigenesis for impaired beta-catenin degrading activity...
  37. doi APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas
    B Filipe
    Centro de Investigacao de Patobiologia Molecular CIPM, Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE IPOLFG, EPE, 1099 023 Lisboa, Portugal
    Clin Genet 76:242-55. 2009
    ..Overall, APC or MUTYH mutations were detected in 42/48 (88%), 14/20 (70%) and 10/38 (26%) of FAP, AFAP and MCRA patients, ..
  38. pmc The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history
    I M Frayling
    Colorectal Cancer Unit, Imperial Cancer Research Fund, St Mark s and Northwick Park Hospitals National Health Service Trust, Harrow, HA1 3UJ, United Kingdom
    Proc Natl Acad Sci U S A 95:10722-7. 1998
    ..to hundreds or thousands of colorectal adenomas and carcinoma and that results from truncating mutations in the APC gene...
  39. pmc Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001
    The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product beta-catenin. APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats...
  40. ncbi APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance
    Jan Sing Hsieh
    Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am Surg 71:336-43. 2005
    ..the sequential accumulation of mutations in specific cancer-related genes, including adenomatous polyposis coli (APC), K-ras, and p53, drives the transition from normal epithelium through increasing adenomatous dysplasia to ..
  41. doi Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas
    Xiangsheng Fu
    Institute for Digestive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Histopathology 55:554-63. 2009
    ..The aim of this study was to determine whether Wnt signalling plays a role in the pathogenesis of SAs, and to clarify the mechanism of Wnt signalling activation in SAs...
  42. doi APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nu rnberg, Glu ckstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 20:3554-64. 2011
    The germline transmission of a mutation in the adenomatous polyposis coli (APC) gene leads to cancer of the gastro-intestinal tract upon somatic inactivation of the remaining allele in familial adenomatous polyposis (FAP) patients...
  43. doi MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events
    S de Vogel
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Ann Oncol 20:1216-22. 2009
    ..in colorectal cancer (CRC), we investigated whether O6-methylguanine DNA methyltransferase (MGMT) and Human Mut-L Homologue 1 (MLH1) promoter hypermethylation are associated with APC, KRAS and BRAF mutations among 734 CRC patients.
  44. pmc APC promoter methylation and protein expression in hepatocellular carcinoma
    Antal Csepregi
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Cancer Res Clin Oncol 134:579-89. 2008
    We investigated the impact of promoter methylation on APC protein expression in patients with hepatocellular carcinoma (HCC).
  45. pmc Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells
    V M Draviam
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    EMBO J 25:2814-27. 2006
    ..We find that RNAi-mediated depletion of two kMAPs, the adenomatous polyposis coli protein (APC) and its binding partner, EB1, are unusual in affecting the movement and orientation of paired sister chromatids at ..
  46. ncbi Asef, a link between the tumor suppressor APC and G-protein signaling
    Y Kawasaki
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113, Japan
    Science 289:1194-7. 2000
    The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors...
  47. ncbi Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
    J Liu
    Department of Oncological Sciences, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Mol Cell 7:927-36. 2001
    The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3beta, forms a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of beta-catenin by the proteasome...
  48. pmc Structural basis for the recognition of Asef by adenomatous polyposis coli
    Zhenyi Zhang
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, China
    Cell Res 22:372-86. 2012
    Adenomatous polyposis coli (APC) regulates cell-cell adhesion and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (GEF; Asef), which is usually autoinhibited through the binding between its Src ..
  49. ncbi Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP)
    Stefan Aretz
    Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany
    Hum Mutat 28:985-92. 2007
    ..During APC mutation screening in 1,248 unrelated patients with familial adenomatous polyposis (FAP), we identified 75 cases ..
  50. pmc Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk
    Sean P Cleary
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dis Colon Rectum 51:1467-73; discussion 1473-4. 2008
    Whereas truncating germline mutations of the adenomatous polyposis coli (APC) gene give rise to familial adenomatous polyposis, missense polymorphisms of APC may confer a weaker risk for colorectal cancer.
  51. ncbi Colorectal polyps in carriers of the APC I1307K polymorphism
    Gad Rennert
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
    Dis Colon Rectum 48:2317-21. 2005
    The probability of colorectal cancer is moderately increased among carriers of the APC I1307K polymorphism. However, it is not known if endoscopic surveillance of this high-risk group is warranted...
  52. doi Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 17:1978-87. 2008
    The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are beta-catenin-binding sites...
  53. ncbi Mutation analysis of APC gene in gastric cancer with microsatellite instability
    Dian Chun Fang
    Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    World J Gastroenterol 8:787-91. 2002
    To evaluate the role of APC mutation in gastric carcinogenesis and to correlate APC mutation with microsatellite instability (MSI) in gastric carcinomas.
  54. ncbi Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasms
    N Peter Zauber
    Department of Medicine, Saint Barnabas Medical Center, Livingston, New Jersey, USA
    Cancer 104:719-29. 2005
    ..authors evaluated the frequency of the carrier status of three ancestral colorectal neoplasm-associated mutations (APC:I1307K, BLM(Ash), and MSH2*1906G>C) found in the Jewish population among a case series with documented ..
  55. ncbi Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is responsible for both inherited and sporadic forms of colon cancer...
  56. ncbi Genetic analyses in consecutive israeli jewish colorectal cancer patients
    Herma H Fidder
    Institute of Gastroenterology and the Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Gastroenterol 100:1376-80. 2005
    Two APC germline mutations, E1317Q and I1307K, have been linked to colorectal cancer (CRC) risk. Whereas the I1307K variant is almost exclusively encountered in (Ashkenazi) Jews, E1317Q is not restricted to certain ethnic populations...
  57. ncbi APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer
    Barry Iacopetta
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Int J Cancer 119:2272-8. 2006
    ..The MethyLight assay was used to provide quantitative estimates of MLH1, P16, TIMP3, P14, DAPK and APC methylation levels in 199 unselected colorectal tumours...
  58. ncbi Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
    J M Seeling
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
    Science 283:2089-91. 1999
    ..The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta form a Wnt-regulated signaling complex that mediates the ..
  59. ncbi Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer
    Y Miki
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cancer Res 52:643-5. 1992
    The APC gene is responsible for familial adenomatous polyposis and is considered to be a tumor suppressor gene associated with development of sporadic colorectal tumors...
  60. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  61. ncbi Expression of the proliferating cell nuclear antigen and protein products of tumour suppressor genes in the human foetal testis
    S Maric
    Department of Biology, School of Medicine, University of Osijek, Osijek, Croatia
    Andrologia 36:24-30. 2004
    Tumour suppressor genes retinoblastoma (Rb1) and adenomatous polyposis coli (Apc) as well as the proliferating cell nuclear antigen (PCNA) are involved in embryonic development...
  62. pmc Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair
    Aimin Li
    Department of Pediatrics, Division of Neonatology, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, California 90033, USA
    Dev Dyn 239:2288-97. 2010
    Adenomatous polyposis coli (Apc) is critical for Wnt signaling and cell migration. The current study examined Apc expression during lung development, injury, and repair...
  63. ncbi Maternal mosaicism for a second mutational event--a novel deletion--in a familial adenomatous polyposis family harboring a new germ-line mutation in the alternatively spliced-exon 9 region of APC
    Sima Davidson
    Molecular Oncology Laboratory, Rambam Medical Center, Haifa, Israel
    Hum Mutat 19:83-4. 2002
    ..Familial Adenomatous Polyposis (FAP) is an autosomal dominant heritable disorder caused by germ-line mutations in the APC gene. To date, more than 300 germ-line mutations within this gene have been described...
  64. pmc Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1
    Katsuhiro Kita
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 17:2331-45. 2006
    In interphase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subset of microtubules (MTs) in cell protrusions, suggesting that APC may regulate the dynamics of these MTs...
  65. doi Association analysis of Wnt pathway genes on prostate-specific antigen recurrence after radical prostatectomy
    Shu Pin Huang
    Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Ann Surg Oncol 17:312-22. 2010
    ..Although aberrant Wnt/beta-catenin (CTNNB1) signaling has been observed in numerous types of human cancers, including PCa, to our knowledge there is currently no information on the role of Wnt signaling gene polymorphisms in PCa...
  66. pmc Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells
    Hongmei Wang
    Department of Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute, Springfield, IL 62794 9677, United States
    Cancer Lett 272:253-9. 2008
    ..Both the CBS and Moser cells were found to express mutant (truncated) APC. Expression of this form of APC did not interfere with the tumor-suppressive function of TGFbeta...
  67. ncbi APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'
    Andrew Latchford
    Polyposis Registry, Cancer Research UK, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Hum Mol Genet 16:78-82. 2007
    Analysis of APC mutations in colonic and duodenal tumours from familial adenomatous polyposis (FAP) patients has shown that the site of the first hit, the germline mutation, can predict the type and position of the somatic mutation or '..
  68. pmc APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment
    Rebecca A Green
    Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
    Mol Biol Cell 16:4609-22. 2005
    Recently, we have shown that a cancer causing truncation in adenomatous polyposis coli (APC) (APC(1-1450)) dominantly interferes with mitotic spindle function, suggesting APC regulates microtubule dynamics during mitosis...
  69. ncbi Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15
    Li Kuo Su
    Department of Molecular and Cellular Oncology, Box 79, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030, USA
    Hum Genet 111:88-95. 2002
    Germline mutations of the adenomatous polyposis coli ( APC) gene cause familial adenomatous polyposis (FAP), an autosomal, dominantly inherited disease that predisposes patients to colorectal cancer...
  70. doi Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers
    Sebastien Gaujoux
    Institut Cochin, Université Paris Descartes Faculté de Médecine, CNRS UMR 8104, Paris, France
    Clin Cancer Res 16:5133-41. 2010
    ..ACT is observed in patients with familial adenomatous polyposis (FAP) with germline APC mutations, as well as in patients with Beckwith-Wiedemann syndrome with Wilms' tumors reported to have WTX somatic ..
  71. pmc Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein
    Zhenyi Zhang
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 6:e23507. 2011
    ..uses two of its three PDZ domains to interact with the C-terminal peptide of the Adenomatous Polyposis Coli (APC) tumor suppressor protein...
  72. ncbi Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
    Nam Chul Ha
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94043, USA
    Mol Cell 15:511-21. 2004
    ..occurs in a multiprotein complex that includes the kinases, beta-catenin, axin, and the Adenomatous Polyposis Coli (APC) protein. The role of APC in this process is poorly understood...
  73. pmc A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation
    Shree Harsha Vijaya Chandra
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Glückstrasse, Erlangen, Germany
    PLoS ONE 7:e34479. 2012
    The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancer cases, leading to the synthesis of truncated APC products and the stabilization of β-catenin...
  74. doi Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study
    B Rivera
    Centro de Investigaciones Biomédicas en Red de Enfermedades Raras CIBERER, Valencia, Spain
    Ann Oncol 22:903-9. 2011
    ..Classical familial adenomatous polyposis (FAP) is characterized by the appearance of >100 colorectal adenomas...
  75. ncbi IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:8545-56. 2007
    ..that beta-catenin co-localizes with IQ-domain GTPase-activating protein 1 (IQGAP1), adenomatous polyposis coli (APC), and N-cadherin at actin-positive membrane ruffles in NIH 3T3 fibroblasts...
  76. ncbi Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC
    Ursula Kurzik-Dumke
    Institute of Medical Microbiology and Hygiene, Laboratory for Comparative Tumor Biology, Johannes Gutenberg University, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Cell Signal 19:1973-85. 2007
    ..we provide evidence for the association of the endogenous Tid50/Tid48 proteins with the adenomatous polyposis coli (APC) tumor suppressor in normal colon epithelium, colorectal cancer cells and mouse NIH3T3 fibroblasts...
  77. pmc The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis
    Jiang Qian
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210 2207, USA
    Gastroenterology 138:1418-28. 2010
    The adenomatous polyposis cell (APC) tumor suppressor is a multifunctional protein involved in cell migration, proliferation, differentiation, and apoptosis...
  78. ncbi A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer
    M L Slattery
    Department of Family and Preventive Medicine University of Utah, Salt Lake City, 84112, USA
    Cancer Res 61:1000-4. 2001
    The adenomatous polyposis coli (APC) gene is important in the etiology of colon cancer. Although germ-line mutations of this gene rarely occur in the population, less penetrant variants of the gene have been reported...
  79. ncbi The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain
    K S Erdmann
    Department of Molecular Neurobiochemistry, Ruhr University Bochum, Germany
    Oncogene 19:3894-901. 2000
    Mutations of the tumor suppressor protein APC (Adenomatous Polyposis Coli) are linked to familiar and sporadic human colon cancer...
  80. ncbi Hot spots in beta-catenin for interactions with LEF-1, conductin and APC
    J P von Kries
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13093 Berlin, Germany
    Nat Struct Biol 7:800-7. 2000
    Interactions between beta-catenin and LEF-1/TCF, APC and conductin/axin are essential for wnt-controlled stabilization of beta-catenin and transcriptional activation...
  81. ncbi Crystal structure of a beta-catenin/Tcf complex
    T A Graham
    Department of Biological Structure University of Washington 98195, Seattle, WA, USA
    Cell 103:885-96. 2000
    ..three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies...
  82. ncbi The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
    M Hart
    Onyx Pharmaceuticals 3031 Research Drive Richmond California 94806 USA
    Curr Biol 9:207-10. 1999
    ..In contrast, beta-TrCP2 did not associate with beta-catenin. We conclude that beta-TrCP is a component of an E3 ubiquitin ligase that is responsible for the targeted degradation of phosphorylated beta-catenin...
  83. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
    ..Two genes on 5q21 that are tightly linked to FAP (MCC and APC) were found to be somatically altered in tumors from sporadic colorectal cancer patients...
  84. ncbi Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    Takashi Watanabe
    Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Dev Cell 7:871-83. 2004
    ..Adenomatous polyposis coli (APC) is also thought to play a pivotal role in polarized cell migration...
  85. doi Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas
    Duncan Azzopardi
    Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Cancer Res 68:358-63. 2008
    ..We have studied this hypothesis by sequencing the adenomatous polyposis coli (APC) gene in 691 unrelated North American patients with CRAs and 969 matched healthy controls...
  86. ncbi The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis
    H Lamlum
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Med 5:1071-5. 1999
    b>APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic mutations (or, infrequently, allelic loss) occur in tumors in FAP (familial adenomatous polyposis)...
  87. pmc Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
    Dina Dikovskaya
    Division of Cell and Developmental Biology, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 176:183-95. 2007
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors...
  88. ncbi The molecular basis of Turcot's syndrome
    S R Hamilton
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2196
    N Engl J Med 332:839-47. 1995
    ..Turcot's syndrome is characterized clinically by the concurrence of a primary brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the molecular level...
  89. ncbi The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    A H Huber
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 105:391-402. 2001
    ..the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic ..
  90. pmc Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2
    JiaYin Zhang
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Biol Cell 20:2381-8. 2009
    ..Adenomatous polyposis coli (APC), a tumor suppressor gene that is commonly mutated in colon cancers, has been suggested in causing CIN; however, ..
  91. ncbi Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability
    Anthony Tighe
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 117:6339-53. 2004
    ..cause chromosome instability remain undefined, mouse ES cells harbouring homozygous adenomatous polyposis coli (APC) mutations are frequently tetraploid...
  92. doi Epigenetic alterations of CDH1 and APC genes: relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast
    Chandra P Prasad
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Life Sci 83:318-25. 2008
    ..Herein, we analyzed promoter methylation status of CDH1 and Adenomatous polyposis coli (APC) genes in 50 IDCs and correlated with expression of E-cadherin (E-CD) and APC proteins and with activation of ..
  93. pmc Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
    David P Minde
    Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands
    Mol Cancer 10:101. 2011
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors...
  94. pmc Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein
    F Zhang
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Building 555, Room 5263, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 97:12577-82. 2000
    Mutation of the adenomatous polyposis coli (APC) gene is an early step in the development of colorectal carcinomas. APC protein is located in both the cytoplasm and the nucleus...
  95. pmc The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
    Jose Sierra
    Regulatory Biology Laboratory, The Salk Insitute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:586-600. 2006
    The APC tumor suppressor controls the stability and nuclear export of beta-catenin (beta-cat), a transcriptional coactivator of LEF-1/TCF HMG proteins in the Wnt/Wg signaling pathway...
  96. ncbi A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor
    J Couture
    Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Genet 57:205-12. 2000
    ..phenotypes have been associated with different sites of germline mutations in the adenomatous polyposis coli gene (APC gene)...
  97. ncbi Identification of deletion mutations and three new genes at the familial polyposis locus
    G Joslyn
    Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84132
    Cell 66:601-13. 1991
    ..nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC)...
  98. ncbi Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon
    B Rubinfeld
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 276:39037-45. 2001
    Axin and the adenomatous polyposis coli protein (APC) interact to down-regulate the proto-oncogene beta-catenin...
  99. ncbi Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation
    J Zumbrunn
    School of Life Sciences, University of Dundee, Dundee, Scotland
    Curr Biol 11:44-9. 2001
    Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial polyposis, a form of inherited colon cancer...
  100. pmc A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  101. pmc Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition
    Y L Wallis
    DNA Laboratory, Birmingham Heartlands Hospital, Bordesley Green, UK
    J Med Genet 36:14-20. 1999
    ..in familial adenomatous polyposis (FAP) is the result of the dominant inheritance of adenomatous polyposis coli (APC) gene mutations...

Research Grants97

  1. Ontogeny and function of zebrafish antigen presenting cells
    David Traver; Fiscal Year: 2011
    ..With the ability to specifically identify each of the APC subsets, we will utilize this information to determine the cellular architecture of secondary lymphoid organs under ..
  2. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..These professional antigen presenting cells (APC) also endocytose HIV-1 and present viral peptides to responding T cells in association with HLA class I and class ..
  3. Myeloid cell interactions with T cells in atherosclerosis
    Klaus F Ley; Fiscal Year: 2013
    ..CXCL4, the product of the Pf4 gene, is pro-atherogenic and drastically alters macrophage phenotype. To investigate APC functions, foam cell formation, antigen presentation and the impact of Pf4 on these processes, we propose to ..
  4. Role of CX3CR1 in adaptive immunity during autoimmune encephalomyelitis
    Astrid E Cardona; Fiscal Year: 2013
    ..The hypothesis behind the proposed research is that CX3CR1/CX3CL1 regulates antigen presenting cell (APC) effector functions influencing the development of pathogenic T cells during experimental autoimmune ..
  5. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2013
    ..of KS, and that this is linked to interactions with HHV-8 infected, professional antigen presenting cells (APC), particularly blood and tissue dendritic cells (DC) and B cells...
  6. The Roles of IBD Associated Genes ATG16L1 and TNFSF15 in Gut Mucosal Inflammation
    David Q Shih; Fiscal Year: 2013
    ..Several studies have shown that TNFSF15 is expressed by antigen presenting cells (APC) and determines the severity of chronic gut inflammation by enhancing Th1, Th17 and Th2 responses...
  7. Thymic B cells and T cell selection
    Haochu Huang; Fiscal Year: 2013
    ..Although the question of which APC is responsible for negative selection has been investigated extensively, the role of thymic B cells as APCs in ..
  8. Targeting antigen presentation to enhance GVL responses after Bone Marrow Transpl
    Pavan Reddy; Fiscal Year: 2013
    ..published during the current funding cycle from our lab, and others, demonstrate that any individual hematopoietic APC subset is dispensable for induction of GVHD, but are collectively, critical for GVL responses...
  9. Antigen Presentation and T cell Programming in Human Autoimmune Diseases
    Kai W Wucherpfennig; Fiscal Year: 2013
    ..The team emphasizes direct investigation of APC - T cell interactions in patients with autoimmune diseases, in particular multiple sclerosis (MS), and integrates ..
  10. UBIQUITIN-DEPENDENT REGULATION OF IMMUNE ACTIVATION
    Lonnie P Lybarger; Fiscal Year: 2010
    ..Antigen presenting cells (APC), including dendritic cells, represent key regulators of immune activation...
  11. Adjuvants'mechanisms
    Yan Shi; Fiscal Year: 2013
    ..Binding of particulate antigens by antigen presenting cells (APC) is a critical step in immune activation...
  12. Imaging and Function of the Immunological Synapse
    David C Parker; Fiscal Year: 2012
    ..lymphocytes recognize antigen as small peptides bound to MHC molecules on the surface of antigen presenting cells (APC)...
  13. Optimizing Induction Conditions for Immunotherapeutic CTL
    Boris Minev; Fiscal Year: 2013
    ..Cytotoxic T Lymphocytes (CTL)-effector cells for immunotherapy 2. Dendritic Cells (DC)-antigen presenting cells (APC) used to induce CTL effectors in vitro 3...
  14. Regulatory Immune Cell Networks in Cancer
    THORSTEN ROMAN MEMPEL; Fiscal Year: 2013
    ..It is becoming apparent that local crosstalk between Treg and myeloid antigen-presenting cells (APC) in the tumor microenvironment is critical for their immunosuppressive function on anti-tumor effector cells, most ..
  15. Using vitamin D glucuronide pro-drugs to prevent/treat colon cancer
    JESSE PAUL GOFF; Fiscal Year: 2013
    ..Mutations in the adenomatous polyposis coli (Apc) gene, originally linked to familial forms of colon cancer, have also been identified in the preponderance of human ..
  16. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2013
    ..in a peptide-specific manner, new data showing rapid antigen non-specific RTL binding to antigen-presenting cells (APC), including macrophages, dendritic cells (DC) and B cells, strongly suggest alternative tolerogenic pathways...
  17. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..Antigen presenting cells (APC), including macrophages and dendritic cells, can remove bacteria, cellular debris and dead cells through ..
  18. TUMOR SUPPRESSION BY THE APC GENE
    Joanna Groden; Fiscal Year: 1999
    ..One such genetic disorder is adenomatous polyposis coli or APC. We mapped and then isolated the APC gene by positional cloning from a region of chromosome 5q...
  19. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 2001
    ..from the investigator's abstract) The majority of colorectal cancers are associated with somatic mutations of the APC tumor suppressor gene...
  20. Exosome-induced innate and antigen-specific immune responses in Type 1 Diabetes
    Yang D Dai; Fiscal Year: 2013
    ..a novel hypothesis that EXO may act as a unique type of endogenous adjuvant and antigen carrier that can condition APC to alter the processing/presenting of the autoantigens and thus, to activate the autoreactive T cells...
  21. Photo-inactivation of Leishmania for safe and effective delivery of surrogate vac
    Kwang Poo Chang; Fiscal Year: 2013
    ..not only do Leishmania resist humoral lytic factors and parasitize exclusively the antigen-presenting cells (APC), i. e. macrophages/dendritic cells, but also live in their phagolysosomes - a desirable site for vaccine delivery...
  22. Dendritic Cells in the Breaking of Peripheral Tolerance in Type 1 Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2012
    ..participants, their activation and functional maturation are controlled by the innate antigen presenting cells (APC) which acquire, process and present pancreatic beta cell antigen in a manner that breaks normal peripheral T cell ..
  23. Role of PGE2 in CNS and peripheral autoimmune disorders
    Doina Ganea; Fiscal Year: 2010
    ..of the molecular and cellular factors involved in the generation, activation, and maintenance of IL-23-producing APC and of pathogenic ThlL-17 will have a significant impact on our understanding and intervention in autoimmune ..
  24. Role of Mucosal DC Subsets in the Control of Influenza A Virus Immunity
    Anna Karolina Palucka; Fiscal Year: 2013
    ..surveillance that include epithelial cells as well as highly specialized professional antigen presenting cells (APC) distributed throughout the conducting airways and the lung parenchyma...
  25. T Cell Activation in Lymph nodes
    Ulrich H von Andrian; Fiscal Year: 2013
    ..immune responses require contact-dependent information exchange between T cells and antigen (Ag)-presenting cells (APC)...
  26. Regulation of Intestinal Immune Homeostasis by APCs and Lymphocytes
    Duke Geem; Fiscal Year: 2013
    ..However, little is known regarding intestinal APC-mediated T cell differentiation...
  27. Mechanisms of HIV-associated Disruption of Intestinal Homeostasis
    Cara C Wilson; Fiscal Year: 2013
    ..Intestinal dendritic cells (IDCs), potent antigen presenting cells (APC) that bridge innate and adaptive immunity, are able to sample luminal bacteria and likely play a key role in ..
  28. Alpha-galactosycleramide as a mucosal adjuvant for HIV antigens
    JAGANNADHA K SASTRY; Fiscal Year: 2010
    ..the use of suitable adjuvants that could directly potentiate the effector T cells and the antigen-presenting cells (APC), such as the dendritic cells (DC), and/or mobilize the innate immune responses...
  29. Mechanisms of Chronic Nod2-mediated Effects in Human Macrophages
    Clara Abraham; Fiscal Year: 2012
    ..NOD2, either alone or in combination with other bacterial receptors, peripherally-derived antigen presenting cells (APC) secrete proinflammatory cytokines...
  30. Mechanisms of apoptotic cell clearance in the human stomach
    Peter B Ernst; Fiscal Year: 2013
    ..Antigen presenting cells (APC) including macrophages and dendritic cells can remove bacteria, cellular debris and dead cells through phagocytosis ..
  31. Molecular network regulating dendritic cell differentiation in cancer
    Dmitry I Gabrilovich; Fiscal Year: 2013
    Dendritic cells (DC) are the most potent antigen presenting cells (APC) and play a critical role in generation of immune responses against bacterial and viral pathogens, tumor antigens, and are involved in the development of autoimmune ..
  32. Mechanisms of Multiple Sclerosis Tissue Pathology
    Claudia F Lucchinetti; Fiscal Year: 2012
    ..We will characterize T cells and APCs in the SAS and define the nature of T cell-APC contacts. Our preliminary data demonstrates myelin laden macrophages in both SAS and CDM lesions...
  33. Intestinal Immune Regulation by IgG and FcRn
    Richard S Blumberg; Fiscal Year: 2013
    ..The current research proposal addresses the unanswered question of how FcRn [in antigen presenting cells (APC)] contributes to ho- meostatic and pathogenic mucosal immune responses...
  34. Immunization Strategies for Autologous HIV Immunotherapy
    Louis D Falo; Fiscal Year: 2012
    ..Besides being the most potent antigen-presenting cells (APC), they determine the nature and magnitude of immune responses and provide an essential link between innate and ..
  35. Targeting Dendritic Cell Subsets in Human Vagina to Elicit Local Immunity
    SangKon Oh; Fiscal Year: 2010
    ..STDs: 1) The subsets of APCs that can elicit optimal quantity and quality of mucosal immunity in the vagina, 2) APC subset-specific surface receptors and activators for: a) delivering vaccines to appropriate subsets of APCs and b) ..
  36. Dissecting Dendritic Cell Function in Autoimmune Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2013
    ..however, that these T cells receive critical pro- and anti-proliferative signals from antigen presenting cells (APC) such as dendritic cells (DC), and that these T cell-APC interactions dramatically influence the effector T cell ..
  37. Mechanisms of increased susceptibility to TB in HIV-Infected individuals
    David H Canaday; Fiscal Year: 2013
    ..of MTB is through cell-mediated immunity primarily involving CD4+ and CD8+ T cells and antigen presenting cells (APC) including both macrophages and dendritic cells (DC). HIV productively infects three of these cell types...
  38. Mechanisms of Effector CD4 Cell Tolerization
    Adam Adler; Fiscal Year: 2009
    ..parenchymal self-antigen are rendered non-responsive/anergic by bone marrow-derived antigen presenting cells (APC) that acquire and indirectly present cognate parenchymal self-antigen...
  39. Modulation of Inflammatory Responses by Helminth Glycans
    Richard D Cummings; Fiscal Year: 2013
    ..of inflammatory responses is mainly mediated via the innate immune system through antigen presenting cells (APC), including dendritic cells (DC) and macrophages (M[unreadable])...
  40. Antigen-specific tolerance in T1 diabetes by IDO loaded functionalized dendrimers
    Paolo Serafini; Fiscal Year: 2013
    ..novel nanostructure gene-based vaccine delivery that efficiently and specifically targets antigen-presenting cells (APC)...
  41. Effect of Chronic Alcohol on Liver APC and Ag-Specific T-Cells
    KATHERINE BREMPELIS; Fiscal Year: 2013
    ..I propose to first study the effects of chronic alcohol exposure on the cell biology of the liver APC populations by using multiple methods such as microscopy, western blotting, qRT-PCR, and in vitro cell assays to ..
  42. Optimized ex vivo expansion of anti-tumor Th1 and Tc1 for adoptive immunotherapy
    Mary L Disis; Fiscal Year: 2013
    ..inflammatory cytokines, modulating the microenvironment to enhance the function of local antigen presenting cells (APC). The resultant increased processing of endogenous tumor cells results in epitope spreading...
  43. In vivo functions of distinct CD103+ intestinal dendritic cell subsets
    Nathan E Welty; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Dendritic cells (DC) are specialized antigen presenting cells (APC) that are critical for initiating and regulating adaptive immune responses...
  44. Criteria-Directed Vaccine Generation Via Ag Mimicry, Adjuvancy, And APC-Targeting
    Timothy J Sellati; Fiscal Year: 2013
    ....
  45. Initiation and maintenance of adaptive immunity to Mycobacterium tuberculosis
    TYLER DALLAS BOLD; Fiscal Year: 2010
    ..I will also determine the contribution of individual APC subsets and the relative contribution of M...
  46. Cyclic Dinucleotides in Combinatorial Immunotherapy for Cancer
    Young J Kim; Fiscal Year: 2013
    ..Magnetovaccination has a high translation potential to quantify APC trafficking...
  47. Mechanistic Dynamic Study of Intranodal Chemokine-aided Antitumor Immune Priming
    ALEX YEE CHEN HUANG; Fiscal Year: 2013
    ..of anti-tumor CD8+ memory T cells, but also will provide direct in vivo evidence for the roles which the host APC and tumors play in priming CD8+ T cells against tumor-associated antigen...
  48. Role of Tim-4 in regulating type 1 diabetes
    Vijay K Kuchroo; Fiscal Year: 2013
    ..However, numerous studies have pointed to defects in antigen- presenting cells (APC) in individuals with T1D...
  49. Immunity to Intracellular Pathogens
    EMIL RAPHAEL UNANUE; Fiscal Year: 2013
    ..e., it has an "adjuvant" effect), inducing cytokine production and cell activation on the antigen presenting cells (APC)...
  50. Signal Initiation from the T-cell Antigen Receptor by Mechanical Force
    TERRI FINKEL; Fiscal Year: 2009
    ..Considering the sufficiency of these three components in TCR triggering, the dynamic nature of T cell-APC interaction, and the constant mechanical stresses on pMHC-TCR interaction, we propose a new model for TCR ..
  51. MHC association in autoimmune arthritis
    Elizabeth D Mellins; Fiscal Year: 2010
    ..affinity affect the stability, longevity, and abundance of class II molecules in model antigen presenting cells (APC) and can modulate antigen presentation...
  52. Galectin-3 in Liver Fibrosis
    XIAOSONG JOY JIANG; Fiscal Year: 2013
    ..In addition, recent data indicate that HSC behave as antigen presenting cells (APC). However, their role in the regulation of hepatic immune responses during fibrogenesis is not well understood...
  53. Pathways of Antigen Presentation to CD8 T Cells In Vivo
    Christopher C Norbury; Fiscal Year: 2013
    ..effectors cells only after recognition of peptide-MHC Class I complexes on the surface of antigen presenting cells (APC). The peptides recognized as part of the peptide-MHC complex can be generated from two spatially distinct sources...
  54. N-3 PUFAs and antigen presenting cells
    Saame R Shaikh; Fiscal Year: 2010
    ..complex (MHC) class I antigen presentation pathway by modifying the biophysical organization of the APC plasma membrane...
  55. Antigen Loaded Particles for Tolerance Induction
    Lonnie D Shea; Fiscal Year: 2013
    ..their distribution, and can be modified with functional groups to promote internalization, target specific APC populations or receptors, and can release bioactive proteins to enhance the tolerogenic response...
  56. Defining the intrahepatic immune response to hepatitis C virus
    Arash Grakoui; Fiscal Year: 2013
    ..Hepatic stellate cells (HSC) are a novel population of intrahepatic APC that undergo dramatic phenotypic and functional changes in response to liver injury or infection...
  57. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2009
    ..investigated how the model protein antigen hen egg-white lysozyme (HEL) was processed by antigen presenting cells (APC);and established the chemical basis for the processing, selection by, and binding of, its various peptides to I-Ak ..
  58. Integration of mucosal immune responses through the enteric nervous system
    DANIEL S MUCIDA; Fiscal Year: 2013
    ..The investigation of the dynamics of APC behavior in the two regions at steady state and under intestinal infection conditions will be followed by the ..
  59. Mechanisms of Tolerance to Renal Maternal Microchimerism
    ANNE MARGUERITE STEVENS; Fiscal Year: 2011
    ..Specific Aim #3 will investigate indirect T lymphocyte alloreactivity to maternal antigens presented by host APC in SLE-N patients compared with controls using apoptotic or necrotic maternal cells as sources of maternal antigens...
  60. Regulation of Cross-Tolerance to Tumor Antigens
    Eduardo M Sotomayor; Fiscal Year: 2013
    ..of this grant, we have identified several signaling pathways that, by regulating the inflammatory status of the APC are critical in the decision leading to T-cell activation versus T-cell tolerance...
  61. Diabetogenic Role of MHC Class I Alleles in NOD Mice
    David V Serreze; Fiscal Year: 2013
    ..NOD mice also undergo negative selection if forced to mature in the presence of engrafted antigen presenting cells (APC) expressing some non-H2g7 MHC haplotypes. Specific aim 2 will determine if diabetogenic HLA-A2...
  62. Adapter proteins and integrin function
    Yoji Shimizu; Fiscal Year: 2013
    ..TCR signaling rapidly increases the functional activity of the LFA-1 integrin, thus enhancing T-APC contacts required for the transmission of the full array of signals required for optimal T cell proliferation and ..
  63. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
    Familial adenomatous polyposis coli (FAP) is an autosomal dominant disorder due to germline mutation of the APC gene and characterized by the formation of hundreds of colorectal adenomatous polyps in young adults...
  64. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2009
    ..cells microdissected from pre-chemoradiation biopsy specimens will be tested for mutations in the p53, k-ras and APC genes, BAT26 deletions, and p16 promoter methylation...
  65. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..will be recruited to contribute in a substantial way to the progress of sub-aims of my parent New Innovator (DP2) Award; the DP2's main specific aims are to develop novel microscopes (Aim 1) and analytical tools (Aim 2) to ..
  66. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..Studies have shown that somatic or germ-line mutations in adenomatous polyposis coli (APC), p53, and genes involved in DMA mismatch repair such as MLH1 and MSH2, and oncogenic activation of KRAS and BRAF ..
  67. MECHANISMS OF INTESTINAL TUMORIGENESIS
    Vincent W Yang; Fiscal Year: 2013
    ..Thus, somatic or germline inactivation of TSGs such as adenomatous polyposis coli (APC), p53 and several genes involved in DNA mismatch repair;and oncogenic activation of KRAS, BRAF and ?-catenin have ..
  68. Use of Closely Related Inbred Strains to Identify Modifier Loci of Tumorigenesis
    Linda D Siracusa; Fiscal Year: 2013
    ..The adenomatous polyposis coli (APC) tumor suppressor gene is mutated in Familial Adenomatous Polyposis (FAP), an inherited disorder that predisposes ..
  69. Investigations on the role of the CDK8 oncogene in colon cancer
    William C Hahn; Fiscal Year: 2013
    ..Inheritance of a germline mutation in APC drives the colon cancer syndrome, Familial Adenomatous Polyposis (FAP), and aberrant activation of the [unreadable]-..
  70. Validation and Extension of the PREMM Model for Inherited Colorectal Cancer
    Sapna Syngal; Fiscal Year: 2013
    ..JAMA 2012) which predicts the likelihood of an individual carrying a germline mutation in the APC and MYH genes, related to Familial Adenomatous Polyposis and MYH-Associated Polyposis...
  71. The role of stromal APC haploinsufficiency in colorectal tumorigenesis
    JAMES PETER ROBINSON; Fiscal Year: 2013
    ..FAP is caused by germline mutations in the Adenomatous Polyposis Coli (APC) gene. APC mutations are also found in sporadic colorectal adenomas and 85% of colon cancers carry APC mutations...
  72. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric Fearon; Fiscal Year: 2009
    ..Recent studies in CRC show that whereas the APC (adenomatous polyposis coli), KRAS, and p53 genes are each frequently altered, many other genes are each mutated in ..
  73. Mouse Models of Sporadic Colorectal Cancer
    MELINDA ANGUS-HILL; Fiscal Year: 2012
    ..The majority of colon cancers are characterized by genetic mutations in adenomatous polyposis coli (APC) or (-catenin, two key components of the Wnt signaling pathway...
  74. Microtubule-associated Rac
    Anna Birukova; Fiscal Year: 2013
    ..We hypothesize that MT-associated adaptor protein APC (adenomatous polyposis coli) can bind and deliver a novel Rac-specific guanine nucleotide exchange factor Asef ..
  75. Uterine-specific genetic modification and lymphangioleiomyomatosis
    JOSE M TEIXEIRA; Fiscal Year: 2012
    ..constitutively activating [unreadable]-catenin or by expressing a truncated allele of adenomatous polyposis coli (APC) and we have shown preliminary evidence that the leiomyomas develop as a result of vascular hemorrhaging and ..
  76. Modifiers of Intestinal Tumor Progression
    Linda D Siracusa; Fiscal Year: 2012
    ..The adenomatous polyposis coli (APC) tumor suppressor gene is mutated in Familial Adenomatous Polyposis (FAP), a dominant inherited disorder that ..
  77. Proteomic Validation of the Min Mouse Model of Colon Cancer
    Anthony Yeung; Fiscal Year: 2007
    ..Adenomatous Polyposis' (FAR) patient has inherited a heterozygous mutation in the tumor suppressor gene APC (adenomatous polyposis coli) and will most likely develop colon cancer in his/her lifetime often because of loss of ..
  78. Beta-catenin-specific regulation of the vitamin D pathway in colon cancer
    Stephen W Byers; Fiscal Year: 2012
    ..The development of virtually all colorectal cancer results from mutation in adenomatous polyposis coli (APC) or 2-catenin genes...
  79. Radial Glial Development And Differentiation
    Eva S Anton; Fiscal Year: 2013
    ..Our preliminary results show that Adenomatous Polyposis Coli (APC) serves an essential function in the development of polarized radial glial scaffold during brain development...
  80. Mitosis, Aneuploidy and Cancer
    Beth A Weaver; Fiscal Year: 2013
    ..Aim 2 will determine whether tumors induced by reduction or mutation of the tumor suppressors p53 and APC (Adenomatous Polyposis Coli) are susceptible to aneuploidy-mediated cell death caused by reduction of CENP-E...
  81. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  82. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2013
    ..Most cases are initiated by mutations in the tumor suppressor Adenomatous polyposis coli (APC)...
  83. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..colorectal epithelium that have been found to be altered early in the two major colorectal carcinogenesis pathways (APC, -catenin, E-cadherin, MSH2), 2) cell cycle events in colorectal epithelial crypt cells (proliferation: Mib-1;..
  84. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2003
    ..early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  85. Abrogating a survival pathway in early colon cancer cells
    Nan Gao; Fiscal Year: 2013
    ..90% hereditary and sporadic colorectal cancers are caused by initial mutation in the adenomatous polyposis coli (APC) gene...
  86. The pVHL/Jade-1/beta-catenin axis in renal cancer
    HERBERT TOD COHEN; Fiscal Year: 2013
    ..knockout mice and multiple intestinal neoplasia (Min) mice, which have a defect in the adenomatous polyposis coli (Apc) gene and have increased beta-catenin activity...
  87. Novel resveratrol analogs and colorectal cancer treatment
    Chunming Liu; Fiscal Year: 2013
    ..CRC is initiated by mutations of adenomatous polyposis coli (APC) and b-catenin genes, which result in abnormal activation of the Wnt signaling pathway...
  88. A model system to study the tumor suppressor APC and its role in Wnt regulation.
    David Roberts; Fiscal Year: 2013
    ..Loss-of-function mutations in the tumor suppressor protein, Adenomatous Polyposis Coli (APC), inappropriately activate the pathway and frequently initiate cancer progression...
  89. Animal model of Gardner's syndrome, a life threatening form of familial cancer
    Yong Sik Bong; Fiscal Year: 2013
    ..FAP is an autosomal dominant disease caused by a mutation in the adenomatous polyposis coli (APC) tumor suppressor gene and is characterized by gastrointestinal polyps...
  90. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2001
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, little is known ..
  91. Tumor suppressor adenomatous polyposis coli and breast carcinogenesis
    Satya Narayan; Fiscal Year: 2007
    Our overall goal is to determine the role of the adenomatous polyposis coli (APC) gene in DNA damage-induced DNA repair activity and breast carcinogenesis...
  92. Regulation of beta-catenin degradation during Wnt signal transduction
    Ethan Lee; Fiscal Year: 2013
    ..Since its identification two decades ago, however, the function of APC in Wnt signaling remains poorly understood...
  93. APC TUMOR SUPPRESSOR PROTEIN IN DEVELOPMENT
    YASMATH AHMED; Fiscal Year: 2003
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the majority of colorectal carcinomas...
  94. p120 and Kaiso dysregulation in intestinal tumorigenesis
    SARAH PALMER SHORT; Fiscal Year: 2013
    ..Loss of the tumor suppressor adenomatous polyposis coli (APC) gene is the initiating mutation in ~80% of these cancers and the driving mutation behind familial adenomatous ..
  95. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ..and organization are important in neurite outgrowth, and cadherins and the protein adenomatous polyposis coli (APC) are well placed to play key roles in coordinating these changes...
  96. DETECTION OF ALTERED APC PROTEINS IN COLON CANCER CELLS
    David Hill; Fiscal Year: 1993
    Mutations in the APC gene appear to be crucial for adenoma formation in inherited Familial Adenomatous Polyposis (FAP) and in the early stages of colorectal cancer...
  97. Analysis of the Chemopreventive Activity of FGN 1
    MARGIE CLAPPER; Fiscal Year: 2004
    ..by decreasing both nuclear levels of beta-catenin and the transcriptional activation of downstream targets of the APC/beta-catenin pathway...