AP2M1

Summary

Gene Symbol: AP2M1
Description: adaptor-related protein complex 2, mu 1 subunit
Alias: AP50, CLAPM1, mu2, AP-2 complex subunit mu, AP-2 mu 2 chain, AP-2 mu chain, HA2 50 kDA subunit, adapter-related protein complex 2 mu subunit, adaptin-mu2, adaptor protein complex AP-2 subunit mu, clathrin adaptor complex AP2, mu subunit, clathrin assembly protein complex 2 medium chain, clathrin coat adaptor protein AP50, clathrin coat assembly protein AP50, clathrin coat-associated protein AP50, clathrin-associated/assembly/adaptor protein, medium 1, plasma membrane adaptor AP-2 50 kDa protein, plasma membrane adaptor AP-2 50kDA protein
Species: human

Top Publications

  1. ncbi Characterization of a protein phosphatase 2A holoenzyme that dephosphorylates the clathrin adaptors AP-1 and AP-2
    Doris Ricotta
    Department of Biomedical Science and Biotechnology, University of Brescia, 25100 Brescia, Italy
    J Biol Chem 283:5510-7. 2008
  2. ncbi Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 238:305-15. 1997
  3. ncbi A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein
    Rahel Byland
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 18:414-25. 2007
  4. ncbi The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]
    S Wyss
    Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
    J Virol 75:2982-92. 2001
  5. ncbi A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
    O Wolf Lindwasser
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T, Room 101, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 82:1166-74. 2008
  6. ncbi A structural explanation for the recognition of tyrosine-based endocytotic signals
    D J Owen
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 282:1327-32. 1998
  7. ncbi Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2
    S M Morris
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Traffic 2:111-23. 2001
  8. ncbi Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif
    H M Craig
    Department of Pathology and, Department of Medicine, San Diego Veterans Affairs Medical Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0679, USA
    Virology 271:9-17. 2000
  9. ncbi Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    E Chuang
    Gwen Knapp Center for Lupus and Immunology Research, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    J Immunol 159:144-51. 1997
  10. ncbi Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
    Y Zhang
    Department of Molecular and Cellular Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 94:9273-8. 1997

Research Grants

  1. Hepatitis C: E2 Molecular Mechanisms
    Martina Buck; Fiscal Year: 2010
  2. BIOCHEMICAL CHARACTERIZATION OF OPIOID BINDING SITES
    Gavril Pasternak; Fiscal Year: 1993
  3. Intracellular mechanisms of reovirus genome replication and particle assembly
    MAX NIBERT; Fiscal Year: 2007
  4. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
  5. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
  6. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2009
  7. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
  8. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
  9. Arrestins in G protein-coupled receptor trafficking
    GREGORY FRALISH; Fiscal Year: 2005
  10. Research Training in Viral mu2 Localization and Function
    John Carvalho; Fiscal Year: 2006

Detail Information

Publications148 found, 100 shown here

  1. ncbi Characterization of a protein phosphatase 2A holoenzyme that dephosphorylates the clathrin adaptors AP-1 and AP-2
    Doris Ricotta
    Department of Biomedical Science and Biotechnology, University of Brescia, 25100 Brescia, Italy
    J Biol Chem 283:5510-7. 2008
    ..large subunits (alpha- and beta2-adaptins) as well as at a single threonine residue (Thr-156) of the medium subunit mu2. Phosphorylation of mu2 is necessary for efficient cargo recruitment, whereas the functional context of the large ..
  2. ncbi Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 238:305-15. 1997
    ..These observations suggest that HIV-1 Env utilizes the protein sorting machinery of the host cells for internalization and sorting at various steps of the endocytic and biosynthetic pathways...
  3. ncbi A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein
    Rahel Byland
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 18:414-25. 2007
    ....
  4. ncbi The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]
    S Wyss
    Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
    J Virol 75:2982-92. 2001
    ..Finally, the C-terminal dileucine was shown to assist the membrane-proximal Y712 motif in restricting the cell surface expression of Env...
  5. ncbi A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
    O Wolf Lindwasser
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T, Room 101, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 82:1166-74. 2008
    ....
  6. ncbi A structural explanation for the recognition of tyrosine-based endocytotic signals
    D J Owen
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 282:1327-32. 1998
    ..for endocytosis by a cytoplasmic sequence motif, tyrosine-X-X-(hydrophobic residue), that is recognized by the mu2 subunit of AP2 adaptors...
  7. ncbi Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2
    S M Morris
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Traffic 2:111-23. 2001
    ..These findings suggest that in addition to previously reported signal-transduction functions, Dab2 could also act as an adaptor protein that may regulate protein trafficking...
  8. ncbi Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif
    H M Craig
    Department of Pathology and, Department of Medicine, San Diego Veterans Affairs Medical Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0679, USA
    Virology 271:9-17. 2000
    ..The interactions with mu1 and mu3 were markedly stronger than the interaction with mu2. Leucine residues of the sorting motif were required for the interactions with mu3 and mu2 and contributed to the ..
  9. ncbi Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    E Chuang
    Gwen Knapp Center for Lupus and Immunology Research, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    J Immunol 159:144-51. 1997
    ..The cytoplasmic domain of CTLA-4 was found to specifically bind to AP50, the medium chain subunit of AP-2 in both yeast two-hybrid and coimmunoprecipitation assays...
  10. ncbi Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
    Y Zhang
    Department of Molecular and Cellular Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 94:9273-8. 1997
    ..In this study, we demonstrate that CTLA-4 is associated with AP50, the medium chain of the clathrin-associated coated pit adaptor protein complex AP2...
  11. ncbi The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides
    A Pauloin
    INRA, Laboratoire de Biologie Cellulaire et Moleculaire, Centre de Recherche de Jouy, Jouy en Josas, France
    Biochem J 296:409-15. 1993
    b>AP50 is a subunit of the assembly polypeptide (AP) subclass AP-2 from bovine brain coated vesicles. It can be phosphorylated in vivo and in vitro on a threonine residue by means of the AP50 kinase activity associated with AP...
  12. ncbi HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses
    Agnès Vendeville
    UMR 5539 CNRS, Département Biologie Santé, Case 107, Universite Montpellier II, 34095 Montpellier Cedex 5, France
    Mol Biol Cell 15:2347-60. 2004
    ..Hence, Tat enters T cells essentially like diphtheria toxin, using clathrin-mediated endocytosis before low-pH-induced and Hsp90-assisted endosomal translocation. Cell responses are then induced from the cytosol...
  13. ncbi Interaction of tyrosine-based sorting signals with clathrin-associated proteins
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 269:1872-5. 1995
    ..The interaction was confirmed by in vitro binding assays. Thus, it is likely that the medium chains serve as signal-binding components of the clathrin-dependent sorting machinery...
  14. ncbi Clathrin-mediated endocytosis in AP-2-depleted cells
    Alison Motley
    University of Cambridge, Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
    J Cell Biol 162:909-18. 2003
    We have used RNA interference to knock down the AP-2 mu2 subunit and clathrin heavy chain to undetectable levels in HeLaM cells...
  15. ncbi Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2
    Melissa Batonick
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
    Virology 342:190-200. 2005
    ..Together these data attribute a role to the AP-2 complex in the regulation of HIV-1 assembly/release...
  16. ncbi CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms
    Jeremy J Rose
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:7413-26. 2005
    ..In contrast, AP-2-mediated enhanced endocytosis constitutes the predominant mechanism for SIV (MAC-239 strain) Nef-induced down-regulation of human CD4 in human cells...
  17. ncbi Microarray analysis in the HSV-1 latently infected mouse trigeminal ganglion
    Shiro Higaki
    Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan
    Cornea 23:S42-7. 2004
    ..To review our previous studies regarding alterations in gene expression in HSV-1 latently infected mouse trigeminal ganglia (TGs) following treatment with immunosuppressants and hyperthermia...
  18. ncbi Molecular characterization of the 50- and 57-kDa subunits of the bovine vacuolar proton pump
    Z Zhou
    Division of Molecular Transport, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 273:5878-84. 1998
    ..Biol. Chem. 269, 28509-25815). It has also been reported that the clathrin-coated vesicle proton pump contains AP50, a 50-kDa component of the AP-2 complex responsible for the assembly of clathrin-coated pits, and that AP50 is ..
  19. ncbi Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules
    John S L Parker
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 76:4483-96. 2002
    ..When the mu2 proteins derived from T1L and the other laboratory's T3D isolate were expressed after transfection of their cloned ..
  20. ncbi Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew)
    J A Rudd
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T
    Eur J Pharmacol 374:77-84. 1999
    ..p.) or naloxonazine (35 mg/kg, i.p.). This indicates an involvement of mu2-opioid receptors within the brain to mediate the anti-emetic effect of fentanyl...
  21. ncbi Characterization of M-class genome segments of muscovy duck reovirus S14
    Yun Zhang
    Avian Infectious Disease Division of National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, PR China
    Virus Res 125:42-53. 2007
    ..Vero cells, which provides evidence that muA might be functional related to the mammalian reovirus (MRV) mu2. The M2 gene was 2155 nucleotides in length and was predicted to encode muB major outer capsid protein of 676 amino ..
  22. ncbi A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 284:32803-12. 2009
    ..Using quantitative endocytosis assays at nerve terminals, we examined how endocytosis depends on the integrity of mu2 function...
  23. ncbi Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2
    W Matsui
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    Biochemistry 29:10791-8. 1990
    ..an AP-2 complex is an asymmetric structure consisting of one large alpha chain, one large beta chain, one medium AP50 chain, and one small AP17 chain. The complex has been shown to contain a core and two appendages...
  24. ncbi Hereditary properdin deficiency in three families of Tunisian Jews
    M Schlesinger
    Pediatric Department, Barzilai Medical Center, Ashkelon, Israel
    Acta Paediatr 82:744-7. 1993
    ..have been found following analysis of the hemolytic activity of the classical (CH50) and the alternative (AP50) complement pathways in the sera of 101 survivors of meningococcal infections and 59 survivors of severe ..
  25. ncbi Interactions of annexins with the mu subunits of the clathrin assembly proteins
    Carl E Creutz
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Biochemistry 44:13795-806. 2005
    ..In a yeast two-hybrid screen for proteins that interact with the N-terminal domain of annexin A2 we identified the mu2 subunit of the clathrin assembly protein complex AP-2...
  26. ncbi Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS
    Ting Zhang
    Department of Pharmacognosy, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
    J Ethnopharmacol 117:351-61. 2008
    ....
  27. ncbi Effect of oxidative phosphorylation uncoupler FCCP and F1F0-ATPase inhibitor oligomycin on the electromechanical activity of human myocardium
    D Zablockaite
    Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania
    Adv Med Sci 52:89-93. 2007
    ....
  28. ncbi Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa
    Kenjiro Matsumoto
    Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283 8555, Japan
    Eur J Pharmacol 549:63-70. 2006
    ..The antinociceptive effect of 7-hydroxymitragynine was significantly blocked by the mu1/mu2-opioid receptor antagonist beta-funaltrexamine hydrochloride (beta-FNA) and the mu1-opioid receptor-selective ..
  29. ncbi Antenatal glucocorticoids attenuate activation of the inflammatory reaction and clotting in preterm lambs
    Anneke S Jaarsma
    Department of Pediatrics, University Hospital Groningen, Groningen, The Netherlands
    Biol Neonate 85:82-9. 2004
    ..Blood was used to determine oxygenation index, alveolar - arterial partial O(2) difference (AaDO(2)), AP50 titer (see text), polymorphonuclear leukocytes (PMNs), beta-glucuronidase, thrombin inhibition, activated partial ..
  30. ncbi Hydroxide-promoted core conversions of molybdenum-iron-sulfur edge-bridged double cubanes: oxygen-ligated topological PN clusters
    Mark L Hlavinka
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Inorg Chem 46:9192-200. 2007
    ..HQ- affords the clusters [(Tp)2Mo2Fe6S8Q(QH)2](3-) (Q = S, Se) in which HQ- is a terminal ligand and Q(2-) is a mu2-bridging atom in the core...
  31. ncbi Trafficking of the human transferrin receptor in plant cells: effects of tyrphostin A23 and brefeldin A
    Elena Ortiz-Zapater
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Valencia, Avda Vicente Andres Estelles s n, 46100 Burjassot Valencia, Spain
    Plant J 48:757-70. 2006
    ..A23, which inhibits the interaction between the YTRF endocytosis signal in the hTfR cytosolic tail and the mu2-subunit of the AP2 complex...
  32. ncbi Sex-limited protein: in vitro and in vivo functions
    F J Beurskens
    Eijkman Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, Utrecht University Hospital, Utrecht, The Netherlands
    Clin Exp Immunol 116:395-400. 1999
    ..C57Bl/6J mice were tested for functional Slp and classical and alternative complement pathway activities (CH50 and AP50 levels, respectively)...
  33. ncbi Early activation of inflammation and clotting in the preterm lamb with neonatal RDS: comparison of conventional ventilation and high frequency oscillatory ventilation
    A S Jaarsma
    Department of Pediatrics, Division of Neonatology, University Hospital Groningen, The Netherlands
    Pediatr Res 50:650-7. 2001
    ..minutes after birth and at 2-h intervals thereafter blood samples, from umbilical catheters, were analyzed for AP50 (complement activation), number of polymorphonuclear leukocytes, beta-glucuronidase, platelet function, activated ..
  34. ncbi A Synechococcus elongatus PCC 7942 mutant with a higher tolerance toward the herbicide bentazone also confers resistance to sodium chloride stress
    Suvendra N Bagchi
    BioVIII Lehrstuhl für Molekulare Zellphysiologie, Fakultat fur Biologie, Universitat Bielefeld, Universitatsstr 25, Bielefeld, 33615, Germany
    Photosynth Res 92:87-101. 2007
    ..Mutant Mu1 has in part been previously characterized. In the present paper we report on another mutant, called Mu2, which also has a higher tolerance toward bentazone...
  35. ncbi Signalling through phospholipase C interferes with clathrin-mediated endocytosis
    Nicolas Carvou
    Department of Physiology, University College London, London WC1E 6JJ UK
    Cell Signal 19:42-51. 2007
    ..The two uptake mechanisms were different as only insulin uptake was reduced when the mu2-subunit of the adaptor complex AP-2 was silenced by RNA interference...
  36. ncbi Rotavirus and reovirus modulation of the interferon response
    Barbara Sherry
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Interferon Cytokine Res 29:559-67. 2009
    ..Reovirus likely inhibits the IFN response by at least 3 virus strain-specific mechanisms. First, the reovirus mu2 protein can induce an unusual nuclear accumulation of IRF9 and repress IFN-stimulated gene (ISG) expression, most ..
  37. ncbi Analgesic effects of Tyr-W-MIF-1: a mixed mu2-opioid receptor agonist/mu1-opioid receptor antagonist
    K A Gergen
    Tulane University School of Medicine, New Orleans, LA 70146, USA
    Eur J Pharmacol 316:33-8. 1996
    ..Recently, intrathecal (i.t.) Tyr-W-MIF-1 was shown to induce potent analgesia mediated through spinal mu2-opioid receptors in mice...
  38. ncbi Silencing and complementation of reovirus core protein mu2: functional correlations with mu2-microtubule association and differences between virus- and plasmid-derived mu2
    John Carvalho
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Virology 364:301-16. 2007
    A low-copy component of mammalian reovirus particles is mu2, an 83-kDa protein encoded by the M1 viral genome segment and packaged within the viral core...
  39. ncbi Synthesis, structural characterization, and theoretical studies of gold(I) and gold(I)-gold(III) thiolate complexes: quenching of gold(I) thiolate luminescence
    Manuel Bardají
    Quimica Inorganica, Facultad de Ciencias, Universidad de Valladolid, E 47005 Valladolid, Spain
    Inorg Chem 45:1059-68. 2006
    ..dinuclear or tetranuclear mixed gold(I)-gold(III) derivatives with a thiolate bridge, namely, [(AuPPh3){Au(C6F5)3}(mu2-2-SC6H4NH2)] (4) and [(C6F5)3Au(mu2-2-SC6H4NH2)(AudppmAu)(mu2-2-SC(6)H4NH2)Au(C6F5)3] (5)...
  40. ncbi Avian reovirus core protein muA expressed in Escherichia coli possesses both NTPase and RTPase activities
    Yu Pin Su
    Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan
    J Gen Virol 88:1797-805. 2007
    ..acid sequence of core protein muA of avian reovirus has indicated that it may share similar functions to protein mu2 of mammalian reovirus...
  41. ncbi Large tandem duplication associated with a Mu2 insertion in Zea mays B-Peru gene
    L J Harris
    Plant Research Centre, Central Experimental Farm, Agriculture Canada, Ottawa, Ontario
    Plant Mol Biol 25:817-28. 1994
    ..Characterization of relevant regions of b-Perum220 revealed a Mu2 element insertion in one copy of a 534 bp sequence...
  42. ncbi Increased ubiquitination and other covariant phenotypes attributed to a strain- and temperature-dependent defect of reovirus core protein mu2
    Cathy L Miller
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    J Virol 78:10291-302. 2004
    ..difference in the morphology of these structures reflects more effective microtubule association by the mu2 core proteins of some viral strains, which form filamentous factories, than by those of others, which form globular ..
  43. ncbi A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptors
    Daisuke Nakayama
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Eur J Pharmacol 563:109-16. 2007
    ..The present results clearly suggest that D-Pro2-Tyr-W-MIF-1 is a selective antagonist for the mu2-opioid receptor in the mouse brain...
  44. ncbi Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9
    Jennifer Zurney
    Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 83:2178-87. 2009
    ..Concordantly, the T1L M1 gene product, mu2, dramatically inhibits IFN-beta-induced reporter gene expression...
  45. ncbi Molecular epidemiology of Candida species isolated from clinical specimens of intensive care unit patients
    Serhat Marol
    Department of Microbiology and Clinical Microbiology, School of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey
    Mycoses 51:40-9. 2008
    ..The strains were typed by random amplified polymorphic DNA (RAPD)-PCR using OPE-03, OPE-18, RP4-2 and AP50-1 primers. In the patients with Candida infections, most isolates exhibited different RAPD patterns. Only three C...
  46. ncbi Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine
    C Mullins
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Gen Genet 262:401-12. 1999
    ..sequence tag (EST) database identified orthologs of family members mammalian medium (mu) chain families mu1, mu2, and mu3, of the corresponding AP complexes, and delta-COP, the analogous component of the coatomer (COPI) complex...
  47. ncbi The antinociceptive effect of trazodone in mice is mediated through both mu-opioid and serotonergic mechanisms
    S Schreiber
    Department of Psychiatry C, The Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel
    Behav Brain Res 114:51-6. 2000
    ..by naloxone, beta-FNA and naloxonazine, but not by nor-BNI or naltrindole, implying involvement of mu1- and mu2-opioid mechanisms. When adrenergic and serotonergic antagonists were used, metergoline (p<0...
  48. ncbi Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles
    C Thurieau
    Universite de Paris V, CNRS No 1188, France
    DNA 7:663-9. 1988
    b>AP50 is the 50,000-dalton protein component found in clathrin-coated vesicles as part of the coat assembly protein (AP) complex, AP-2...
  49. ncbi Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1
    Sandra Fausia Soukup
    Functional Genomics Unit, CIC bioGUNE, Derio, Spain
    PLoS Genet 5:e1000532. 2009
    ..Co-localisation of anti-Nec with anti-AP50, Rab5, and Rab7 antibodies establishes that the serpin is processed through multi-vesicular bodies and delivered to ..
  50. ncbi Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120
    D J Stephens
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 335:567-72. 1998
    ..Whereas the wild-type version of the cytosolic domain of TGN38 interacts with highest affinity with mu2, we show that the cytosolic domain of lgp120 interacts almost exclusively with mu3A...
  51. ncbi Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis
    Shawn F Bairstow
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 281:20632-42. 2006
    ..We have discovered a direct interaction between the mu2-subunit of the AP2 complex and PIPKIgamma661 via a yeast two-hybrid screen...
  52. ncbi Serine 331 and tyrosine 333 are both involved in the interaction between the cytosolic domain of TGN38 and the mu2 subunit of the AP2 clathrin adaptor complex
    D J Stephens
    Department of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 272:14104-9. 1997
    ..It was recently demonstrated that this motif specifically interacts with the mu2 subunit of the AP2 adaptor complex...
  53. ncbi Orthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces
    Jonghwa Kim
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02115, USA
    Virus Res 101:15-28. 2004
    ..Other evidence indicates that the Orthoreovirus mu2 and Aquareovirus VP5 proteins are homologous, suggesting that VP5 is a core protein as mu2 is known to be...
  54. ncbi Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex
    Takashi Kanematsu
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka, Japan
    J Neurochem 101:898-905. 2007
    ..The clathrin heavy chain, mu2 and beta2 subunits of AP2 and PRIP-1, were complexed with GABA(A) receptor in brain extract as analyzed by co-..
  55. ncbi Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma
    Marisa A Gallicchio
    Monash University, Department of Medicine, Alfred Hospital, Commercial Rd, Prahran, 3004, Australia
    Biochim Biophys Acta 1803:919-30. 2010
    ..AGE-BSA increased binding of NKA to the alpha-adaptin but not beta2- or mu2-adaptin subunits of the AP-2 clathrin pit adaptor complex...
  56. ncbi Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface
    Dominik Wiemuth
    Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    Biochem J 405:147-55. 2007
    ..We confirm that ENaC is associated with the mu2 subunit of the AP-2 (adaptor protein 2) clathrin adaptor...
  57. ncbi Involvement of spinal mu1-opioid receptors on the Tyr-d-Arg-Phe-sarcosine-induced antinociception
    Hirokazu Mizoguchi
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Eur J Pharmacol 540:67-72. 2006
    ..co-treatment with Tyr-D-Pro-Trp-Phe-NH2 (D-Pro2-endomorphin-1) or Tyr-D-Pro-Trp-Gly-NH2 (D-Pro2-Tyr-W-MIF-1), the mu2-opioid receptor antagonists, did not affect the TAPS-induced antinociception...
  58. ncbi Anti-complement effects of lactoferrin-derived peptides
    Ørjan Samuelsen
    Department of Medical Microbiology, University Hospital of North Norway, P O Box 56, N 9038 Tromsø, Norway
    FEMS Immunol Med Microbiol 41:141-8. 2004
    ..No inhibitory effect of these peptides was observed on the alternative complement pathway in an AP50 assay...
  59. ncbi Comparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolates
    Peng Yin
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, R3E 0W3 Canada
    Virol J 1:6. 2004
    The reovirus M1 genome segment encodes the mu2 protein, a structurally minor component of the viral core, which has been identified as a transcriptase cofactor, nucleoside and RNA triphosphatase, and microtubule-binding protein...
  60. ncbi The development of the complement system after 28 weeks' gestation
    B Wolach
    Department of Paediatrics, Meir General Hospital, Sapir Medical Center, Kfar Saba, Israel
    Acta Paediatr 86:523-7. 1997
    ..To assess the levels and development of the various complement components in preterm infants, particularly among those born before 34 weeks' gestation...
  61. ncbi A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse
    Hiroyuki Watanabe
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    J Pharmacol Exp Ther 312:1075-81. 2005
    ..d-Pro(2)-Tyr-W-MIF-1 may also discriminate between Tyr-W-MIF-1-induced antinociception and the antinociception induced by endomorphin-1 or DAMGO, all of which show a preference for the mu(2)-opioid receptor in the spinal cord...
  62. ncbi Gene expression profiling of the early pulmonary response to hyperoxia in mice
    Sandra Perkowski
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, 3850 Spruce Street, Philadelphia, PA 19104 6010, USA
    Am J Respir Cell Mol Biol 28:682-96. 2003
    ..a number of other antioxidant enzymes, including glutathione peroxidase, glutathione-S-Transferase (GST) Pi1, GST mu2, and heme oxygenase-1 showing relatively moderate increases...
  63. ncbi Recognition of double strand breaks by a mutator protein (MU2) in Drosophila melanogaster
    Raghuvar Dronamraju
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    PLoS Genet 5:e1000473. 2009
    ..A mutation, mu2(a), in Drosophila melanogaster decreases the rate of repair of double strand DNA breaks in oocytes, thus leading to ..
  64. ncbi Inhibition of reovirus by mycophenolic acid is associated with the M1 genome segment
    Laura L Hermann
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 0W3
    J Virol 78:6171-9. 2004
    ..differences in sensitivity to MPA mapped to the viral M1 genome segment, which encodes the minor core protein mu2. MPA also inhibited replication of both strains of reovirus in a variety of other cell lines, including Vero monkey ..
  65. ncbi Bonding trends of thiosemicarbazones in mononuclear and dinuclear copper(I) complexes: syntheses, structures, and theoretical aspects
    Tarlok S Lobana
    Department of Chemistry, Guru Nanak Dev University, Amritsar, India
    Inorg Chem 45:1535-42. 2006
    ..I (5), Br (6), Cl (7), pyridine-2-carbaldehyde thiosemicarbazone (Hpytsc)], (ii) halogen-bridged dimers, [Cu2(mu2-X)2(eta1-S-Htsc)2(Ph3P)2] [X, Htsc = Br (3), Hbtsc; I (8), furan-2-carbaldehyde thiosemicarbazone (Hftsc); I (11), ..
  66. ncbi [Anticholinergic effect of procainamide and its sulfonylcarbamide derivatives on electromechanical activity in guinea pig atrium]
    Herta Gurskaite
    Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania
    Medicina (Kaunas) 41:1054-60. 2005
    ..perfusion of atrial strips with Tyrode solution), mean action potential duration measured at 90% (AP90) and 50% (AP50) of repolarization were 92.5+/-4.5 ms and 44.4+/-2.9 ms (n=18), respectively, and contraction force was of 2.7+/-0...
  67. ncbi Recruitment of Cdc42 through the GAP domain of RLIP participates in remodeling of the actin cytoskeleton and is involved in Xenopus gastrulation
    Laurent Boissel
    Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS UMR 7592, Universités Paris VI et Paris VII, 2 place Jussieu, 75251 Paris Cedex 05, France
    Dev Biol 312:331-43. 2007
    ..We also demonstrate that the complete N-terminal domain of RLIP containing the mu2 binding domain (mu2BD) and the GAP domain induces disruption of the actin cytoskeleton when targeted to the plasma ..
  68. ncbi Antinociceptive effect of buprenorphine in mu1-opioid receptor deficient CXBK mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Life Sci 60:PL 333-7. 1997
    ..These results support our previous hypothesis that mu1- rather than mu2-, delta- or kappa-opioid receptors are involved in the antinociceptive effects of buprenorphine.
  69. ncbi Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling
    Anna Mizutani
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Biochem 148:733-41. 2010
    ..Arkadia thus appears to regulate EGF signalling by modulating endocytosis of EGFR through interaction with AP2 complex...
  70. ncbi Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2
    X Wang
    Institut fur Physiologische Chemie, Medizinische Fakultat, Ruhr Universitat Bochum, Germany
    FEBS Lett 402:57-61. 1997
    ..60% amino acid sequence identity with each other and 27-31%, identity with mu1-adaptin (ap47) and mu2-adaptin (ap50)...
  71. ncbi Synthesis, structural characterization and biological study of new organotin(IV), silver(I) and antimony(III) complexes with thioamides
    S K Hadjikakou
    Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    J Inorg Biochem 102:1007-15. 2008
    ..et(3)nh)+]2.(dmso)2.(h2o)} (13), {[ag4cl4(mu3-sthpmh2)4]n} (14), {[ag6(mu2-br)6(mu2-sthpmh2)4(mu3-sthpmh2)2]n} (15), {[ag4(mu2sthpmh2)6](no3)4}(n) (16), {[agcl(tptp)]4} (17), [agx(tptp)3] ..
  72. ncbi IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis
    Qi Cao
    Centre for Transplantation and Renal Research, University of Sydney, Westmead Millennium Institute, and Centre for Kidney Research, Children s Hospital at Westmead, Level 2 Block D, Darcy Road, Westmead, New South Wales, Australia
    J Am Soc Nephrol 21:933-42. 2010
    ..Here, macrophages modified ex vivo by IL-10/TGF-beta (IL-10/TGF-beta Mu2) significantly attenuated renal inflammation, structural injury, and functional decline in murine adriamycin ..
  73. ncbi Evaluation of epithelial cell proliferating activity and fibroblast nuclear kariometry in recurrent pterygium treated with mitomycin C
    Gildasio Castello de Almeida Junior
    Departamento de Oftalmologia, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brasil
    Arq Bras Oftalmol 71:568-75. 2008
    ..Ki-67 antigen to evaluate epithelial cell proliferation and fibroblast nuclear kariometry were used to assist treatment evaluation...
  74. ncbi Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster
    A Kasravi
    Developmental Biology Center, University of California, Irvine, California 92697, USA
    Genetics 152:1025-35. 1999
    We present here the molecular cloning and characterization of the mutator2 (mu2) gene of Drosophila melanogaster together with further genetic analyses of its mutant phenotype...
  75. ncbi Cloning of the gene encoding the murine clathrin-associated adaptor medium chain mu 2: gene organization, alternative splicing and chromosomal assignment
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Gene 210:187-93. 1998
    ..Here, we report the cloning of the (MMU)CLAPM1 gene encoding the murine mu 2 chain, the first member of the family for which this information has become ..
  76. ncbi [Hereditary complement C5 deficiency: study of 3 Tunisian adult cases and literature review]
    Yusr Zerzri
    Laboratoire d Immunologie, hôpital Rabta, Tunis, Tunisie
    Tunis Med 88:269-76. 2010
    ..Hereditary complement deficiency, mainly those of the terminal pathway (C5-C9), is at increased risk for septic meningitides particularly meningococcal ones...
  77. ncbi Electron-structure calculations and bond order analysis using density functional theory of cationic dinuclear arene ruthenium complexes
    Emmanuel Penka Fowe
    Institute of Inorganic and Analytical Chemistry, University of Fribourg, Perolles, CH 1700, Fribourg, Switzerland
    Inorg Chem 47:42-8. 2008
    The structure and nature of the metal-metal bonding interaction in the cationic complexes [(eta6-C6Me6)2Ru2(mu2-H)3]+ (1), [(eta6-C6Me6)2Ru2(mu2-H)2(mu2-1,4-SC6H4Br)]+ (2), [(eta6-C6Me6)2Ru2(mu2-H)(mu2-1,4-SC6H4Br)2]+ (3), and [(eta6-..
  78. ncbi Role of bacterioferritin comigratory protein and glutathione peroxidase-reductase system in promoting bentazone tolerance in a mutant of Synechococcus elongatus PCC7942
    Palash Kumar Das
    Department of Biological Sciences, Rani Durgavati University, Jabalpur, Madhya Pradesh, India
    Protoplasma 249:65-74. 2012
    In this article, we describe the modifications in the antioxidant system of Synechococcus elongatus PCC7942 mutant Mu2 capable of growing at five times higher concentration of bentazone than wild type...
  79. ncbi Intracellular posttranslational modifications of S1133 avian reovirus proteins
    R Varela
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Santiago de Compostela, Spain
    J Virol 70:2974-81. 1996
    ..The structural polypeptide mu2 was shown to be intracellularly modified by both myristoylation and proteolysis...
  80. ncbi [Anticholinergic effect of 2-aminopyridine and its sulfonylcarbamide derivatives on electromechanical activity in guinea pig atrium]
    Vida Gendviliene
    Institute of Cardiology, Kaunas University of Medicine, Sukileliu 17, 50161 Kaunas, Lithuania
    Medicina (Kaunas) 43:808-15. 2007
    ..of atrial strips with Tyrode solution), an average of action potential duration, measured at 90% (AP90) and 50% (AP50) of repolarization, were 112.32+/-6.07 ms and 50.21+/-3.25 ms, (n=19), respectively, and contraction force was of 1...
  81. ncbi Regulation of Na,K-ATPase during acute lung injury
    Emilia Lecuona
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Bioenerg Biomembr 39:391-5. 2007
    ..This process promotes the alpha1-subunit recognition by the mu2 subunit of the adaptor protein-2 and its endocytosis trough a clathrin dependent mechanism...
  82. ncbi Morphometric investigations of terminal villi of diabetic placentas in relation to the White classification of diabetes mellitus
    F Stoz
    Department of Obstetrics and Gynecology, University of Ulm, West Germany
    J Perinat Med 15:193-8. 1987
    ..significant with bigger cross sectional surfaces of the terminal villi, particularly, when classified in 3000 mu2-steps, the number of the villous vessels and number of epithelial plates...
  83. ncbi Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:29549-62. 2007
    ....
  84. ncbi Targeting signals and subunit interactions in coated vesicle adaptor complexes
    L J Page
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, England
    J Cell Biol 131:619-30. 1995
    ..The subunit composition of the plasma membrane adaptor complex is alpha-adaptin, beta-adaptin, AP50, and AP17; while that of the TGN adaptor complex is gamma-adaptin, beta'-adaptin, AP47, and AP19...
  85. ncbi Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor
    G C Rossi
    George C Cotzias Laboratory of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    FEBS Lett 369:192-6. 1995
    ..Inhibition of gastrointestinal transit and spinal morphine analgesia, two mu2 actions, are blocked only by the probe against exon 4 and not by those directed against exon 1...
  86. ncbi Activity and in vitro reassembly of the coated vesicle (H+)-ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2
    Q Liu
    Department of Cellular and Molecular Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111
    J Biol Chem 269:31592-7. 1994
    We have previously shown that the 50-kDa subunit of the clathrin assembly complex AP-2 (AP50) stoichiometrically binds to and is immunoprecipitated with the vacuolar (H+)-ATPase (V-ATPase) from clathrin-coated vesicles (Myers, M...
  87. ncbi Synthesis and structures of bis(dithiolene)tungsten(IV,VI) thiolate and selenolate complexes: approaches to the active sites of molybdenum and tungsten formate dehydrogenases
    Stanislav Groysman
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Inorg Chem 46:4090-102. 2007
    ..Selenolate complexes are less stable than similar thiolate species; decomposition products were identified as [WV2(mu2-Q)2(S2C2Me2)2]2- and [WIV,V2(mu2-Se)(S2C2Me2)4]-...
  88. ncbi Infrared spectroscopic and theoretical studies on the reactions of copper atoms with carbon monoxide and nitric oxide molecules in rare-gas matrices
    Ling Jiang
    National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    J Phys Chem A 111:2690-6. 2007
    ..New products, (CuCO)2, [NO]Cu[NO], Cu2(mu2-NO), and Cu(NO)2Cu, have been formed in the copper experiments and characterized using infrared spectroscopy on the ..
  89. ncbi Two rat homologs of clathrin-associated adaptor proteins
    J Pevsner
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical School, CA 94305
    Gene 146:279-83. 1994
    ..These three proteins share approx. 80% amino acid (aa) identity to each other and have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles...
  90. ncbi Tetrakis(mu2-4-aminobenzoato)di-mu3-oxido-tetrakis[dibutyltin(IV)]
    Anthony Linden
    Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Acta Crystallogr C 66:m58-61. 2010
    ..The amine groups not involved in the hydrogen-bonding interactions have significant N-H...pi interactions with neighbouring aminobenzene rings...
  91. ncbi Recruitment of the adaptor protein 2 complex by the human immunodeficiency virus type 2 envelope protein is necessary for high levels of virus release
    Beth Noble
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Virol 80:2924-32. 2006
    ....
  92. ncbi Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins
    Sergiy Tyukhtenko
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Biochemistry 47:4160-8. 2008
    ..In addition, we have shown that the juxtamembrane region of L1-CT has some binding affinity to AP2-mu2, although the specificity of this interaction needs further investigation...
  93. ncbi From a paramagnetic, mononuclear supersulfidonickel(II) complex to a diamagnetic dimer with a four-sulfur two-electron bond
    Shenglai Yao
    Metalorganics and Inorganic Materials, Institute of Chemistry, Technische Universitat Berlin, Strasse des 17, Juni 135, Sekr C2, D 10623 Berlin, Germany
    J Am Chem Soc 130:13536-7. 2008
    ..Gentle sulfur transfer of 1(1) to Ph3P or its reaction with [LNi] affords solely the genuine disulfide complex 3 having a Ni2(mu-mu2:mu2-S2) core.
  94. ncbi Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking
    Fangtian Huang
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:43411-7. 2003
    ..Analysis of cells expressing dominant-interfering mutant mu2 subunit of AP-2 suggested that beta2 phosphorylation is partially mediated by the receptor interaction with the mu2 ..
  95. ncbi The influence of selenium supplementation on the immunity of corticoid-dependent asthmatics
    F Gazdik
    Institute of Preventive and Clinical Medicine, Department of Clinical Immunology, Limbova 14, SK 833 01 Bratislava 37, Slovakia
    Bratisl Lek Listy 103:17-21. 2002
    ..Selenium (Se) is a trace element that is essential for immune functions, and protects the immune system from oxidative damage...
  96. ncbi Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6
    Sophia Semerdjieva
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, England, UK
    J Cell Biol 183:499-511. 2008
    ..exchange factor activity requires hRME-6 binding to alpha-adaptin ear, which displaces the ear-associated mu2 kinase AAK1...
  97. ncbi [Complement protein hereditary deficits during purulent meningitis: study of 61 adult Tunisian patients]
    M Kallel-Sellami
    Laboratoire d Immunologie, Hôpital La Rabta EL Jaabari, 1007 Tunis, Tunisie
    Arch Inst Pasteur Tunis 83:25-34. 2006
    ..Functional activity of the classical and the alternative pathways of complement (CH50 and AP50 respectively) were measured according to standard haemolytic procedures...
  98. ncbi Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor
    Stephen J Royle
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 277:35378-85. 2002
    ..Mutation of either the tyrosine-binding pocket of the mu2 subunit of adaptor protein-2 or the YXXGL motif in the receptor C terminus caused a decrease in receptor ..
  99. ncbi The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling
    Vladimir V Lunin
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    J Biol Chem 279:23422-30. 2004
    ..a component of a Golgi-associated membrane-trafficking complex) and the sigma2 and amino-terminal portion of the mu2 subunits of the clathrin adaptor complex AP2...
  100. ncbi Detection of novel oral phylotypes associated with periodontitis
    Mitsuo Sakamoto
    Japan Collection of Microorganisms, RIKEN, Wako, 351 0198, Saitama, Japan
    FEMS Microbiol Lett 217:65-9. 2002
    ..The purpose of this study was to design specific PCR primers for five phylotypes AP12, AP21, AP24, AP50, and RP58, which are deeply branched particularly in the phylogenetic tree, and determine the prevalence of these ..
  101. ncbi Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex
    J Iwahashi
    Department of Virology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Cell Mol Biol (Noisy-le-grand) 49:OL467-71. 2003
    ..Yeast two-hybrid screening indicated that RTN1-A and RTN1-B interacted with AP50, a component of the AP-2 adaptor complex involved in endocytosis. In contrast, RTN1-C did not interact with AP50...

Research Grants65

  1. Hepatitis C: E2 Molecular Mechanisms
    Martina Buck; Fiscal Year: 2010
    ..Clathrin-mediated endocytosis (CME), through site-specific phosphorylations of <2(AP50), a subunit of the heterodimeric cargo adaptor AP2, a key regulator of clathrin-mediated receptor endocytosis and ..
  2. BIOCHEMICAL CHARACTERIZATION OF OPIOID BINDING SITES
    Gavril Pasternak; Fiscal Year: 1993
    ..Pharmacological and binding approaches suggest that existence of mu1 and mu2 receptors...
  3. Intracellular mechanisms of reovirus genome replication and particle assembly
    MAX NIBERT; Fiscal Year: 2007
    ..are proposed to be studied insofar as they associate with muNS, with a special emphasis on the viral sigmaNS and mu2 proteins, which have also been implicated in determining features or functions of the factories...
  4. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
    ..shown to be capable of performing fast, accurate and noninvasive measurements of the elastic (mu1) and viscous (mu2) terms of the shear modulus along and across the myofibers of excised myocardium and striated muscle...
  5. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
    ..shown to be capable of performing fast, accurate and noninvasive measurements of the elastic (mu1) and viscous (mu2) terms of the shear modulus along and across the myofibers of excised myocardium and striated muscle...
  6. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2009
    ..Early pharmacological studies have proposed several mu opioid receptor subtypes: mu1, mu2 and morphine-62-glucuronide (M6G)...
  7. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
    ..Early pharmacological studies have proposed several mu opioid receptor subtypes: mu1, mu2 and morphine-62-glucuronide (M6G)...
  8. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
    ..Early pharmacological studies have proposed several mu opioid receptor subtypes: mu1, mu2 and morphine-62-glucuronide (M6G)...
  9. Arrestins in G protein-coupled receptor trafficking
    GREGORY FRALISH; Fiscal Year: 2005
    ..We have recently discovered that a small region of the N-terminus of beta-arrestin2 binds to the mu2-adaptin subunit of AP2...
  10. Research Training in Viral mu2 Localization and Function
    John Carvalho; Fiscal Year: 2006
    ..The mu2 protein, an inner capsid component of reovirus, is suggested to be a regulator of viral cytopathology...
  11. Stoichiometry and modular retrieval of ENaC
    James Stockand; Fiscal Year: 2007
    ..the channel for ubiquitinylation via Nedd4 ubiquitin ligases; and the latter motif is known to interact with the mu2 subunit of the AP-2 complex, which targets proteins for clathrin coated-pit endocytosis mediated by dynamin...
  12. Stoichiometry and modular retrieval of ENaC
    James Stockand; Fiscal Year: 2009
    ..the channel for ubiquitinylation via Nedd4 ubiquitin ligases; and the latter motif is known to interact with the mu2 subunit of the AP-2 complex, which targets proteins for clathrin coated-pit endocytosis mediated by dynamin...
  13. PHARMACOLOGY OF OPIOID RECEPTOR SUBTYPES
    Gavril Pasternak; Fiscal Year: 1993
    ..Furthermore, they act in different regions of the neuroaxis: mu1 and kappa3 supraspinally and mu2, kappa l and delta spinally...
  14. DEVELOPMENT OF RECEPTOR-SPECIFIC OPIOID PEPTIDE ANALOGS
    Peter Schiller; Fiscal Year: 1992
    ..The compound developed might also be useful for the further demonstration of putative opioid subtypes (mu1, mu2, eta1, eta2, eta3, eta4, etc.) and as selective ligands for such subtypes...
  15. MOLECULAR MECHANISMS MEDIATING CD22 ACCESSORY FUNCTION
    LOUIS JUSTEMENT; Fiscal Year: 2003
    ..Additionally, studies performed in this laboratory have determined that CD22 physically interacts with AP50, the medium chain subunit of the AP-2 complex, via a tyrosine-containing motif...
  16. BIOCHEMICAL CHARACTERIZATION OF OPIATE BINDING SITES
    Gavril Pasternak; Fiscal Year: 1991
    ..Recent studies suggest two subtypes of mu receptors. The mu2 site corresponse to the classical morphine- selective mu recePtor previously characterized in peripheral bioassays ..
  17. REGULATION OF ACETYLCHOLINE RECEPTOR EXPRESSION
    Lin Mei; Fiscal Year: 2007
    ..We find that SHP2 binds to ErbB proteins in response to NRG and at the same time interacts with the mu2 subunit ofAP2, a complex implicated in receptor endocytosis...
  18. The role of reovirus factories in viral RNA regulation.
    Cathy Miller; Fiscal Year: 2007
    ....
  19. E3 Ligases and Deubiquitinases in GPCR downregulation
    Sudha Shenoy; Fiscal Year: 2009
    ..abstract_text> ..
  20. E3 Ligases and Deubiquitinases in GPCR Down Regulation
    Sudha K Shenoy; Fiscal Year: 2010
    ....