AP2M1

Summary

Gene Symbol: AP2M1
Description: adaptor-related protein complex 2, mu 1 subunit
Alias: AP50, CLAPM1, mu2, AP-2 complex subunit mu, AP-2 mu 2 chain, AP-2 mu chain, HA2 50 kDA subunit, adapter-related protein complex 2 mu subunit, adaptin-mu2, adaptor protein complex AP-2 subunit mu, clathrin adaptor complex AP2, mu subunit, clathrin assembly protein complex 2 medium chain, clathrin coat adaptor protein AP50, clathrin coat assembly protein AP50, clathrin coat-associated protein AP50, clathrin-associated/assembly/adaptor protein, medium 1, plasma membrane adaptor AP-2 50 kDa protein, plasma membrane adaptor AP-2 50kDA protein
Species: human

Top Publications

  1. ncbi Characterization of a protein phosphatase 2A holoenzyme that dephosphorylates the clathrin adaptors AP-1 and AP-2
    Doris Ricotta
    Department of Biomedical Science and Biotechnology, University of Brescia, 25100 Brescia, Italy
    J Biol Chem 283:5510-7. 2008
  2. pmc HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation
    Mary Ann Checkley
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, Frederick, MD 21702 1201, USA
    J Mol Biol 410:582-608. 2011
  3. ncbi Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2
    Melissa Batonick
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
    Virology 342:190-200. 2005
  4. ncbi Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 238:305-15. 1997
  5. pmc Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly
    Ruba H Ghanam
    Department of Microbiology, University of Alabama at Birmingham Birmingham, AL, USA
    Front Microbiol 3:55. 2012
  6. pmc Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor
    Rittik Chaudhuri
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bldg 18T, Rm 101, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 81:3877-90. 2007
  7. pmc A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
    O Wolf Lindwasser
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T, Room 101, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 82:1166-74. 2008
  8. ncbi Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    E Chuang
    Gwen Knapp Center for Lupus and Immunology Research, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    J Immunol 159:144-51. 1997
  9. doi Essential and supporting host cell factors for HIV-1 budding
    Aurelien Dordor
    Unit of Virus Host Cell Interactions UMI 3265 Université Joseph Fourier EMBL CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
    Future Microbiol 6:1159-70. 2011
  10. pmc Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
    Y Zhang
    Department of Molecular and Cellular Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 94:9273-8. 1997

Detail Information

Publications175 found, 100 shown here

  1. ncbi Characterization of a protein phosphatase 2A holoenzyme that dephosphorylates the clathrin adaptors AP-1 and AP-2
    Doris Ricotta
    Department of Biomedical Science and Biotechnology, University of Brescia, 25100 Brescia, Italy
    J Biol Chem 283:5510-7. 2008
    ..large subunits (alpha- and beta2-adaptins) as well as at a single threonine residue (Thr-156) of the medium subunit mu2. Phosphorylation of mu2 is necessary for efficient cargo recruitment, whereas the functional context of the large ..
  2. pmc HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation
    Mary Ann Checkley
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, Frederick, MD 21702 1201, USA
    J Mol Biol 410:582-608. 2011
    ..Here, we review our current understanding of HIV-1 Env glycoprotein trafficking and incorporation into virions...
  3. ncbi Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2
    Melissa Batonick
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
    Virology 342:190-200. 2005
    ..Together these data attribute a role to the AP-2 complex in the regulation of HIV-1 assembly/release...
  4. ncbi Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 238:305-15. 1997
    ..These observations suggest that HIV-1 Env utilizes the protein sorting machinery of the host cells for internalization and sorting at various steps of the endocytic and biosynthetic pathways...
  5. pmc Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly
    Ruba H Ghanam
    Department of Microbiology, University of Alabama at Birmingham Birmingham, AL, USA
    Front Microbiol 3:55. 2012
    ..In this review, we summarize the current understanding of the structural and functional role of MA in HIV replication...
  6. pmc Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor
    Rittik Chaudhuri
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bldg 18T, Rm 101, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 81:3877-90. 2007
    ..Together, these results support a model in which HIV-1 Nef downregulates CD4 by promoting its accelerated endocytosis by a clathrin/AP2 pathway...
  7. pmc A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
    O Wolf Lindwasser
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T, Room 101, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 82:1166-74. 2008
    ....
  8. ncbi Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    E Chuang
    Gwen Knapp Center for Lupus and Immunology Research, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    J Immunol 159:144-51. 1997
    ..The cytoplasmic domain of CTLA-4 was found to specifically bind to AP50, the medium chain subunit of AP-2 in both yeast two-hybrid and coimmunoprecipitation assays...
  9. doi Essential and supporting host cell factors for HIV-1 budding
    Aurelien Dordor
    Unit of Virus Host Cell Interactions UMI 3265 Université Joseph Fourier EMBL CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
    Future Microbiol 6:1159-70. 2011
    ..Here we review recent advances in understanding the role of host cell factors recruited by Gag during HIV-1 assembly and budding...
  10. pmc Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
    Y Zhang
    Department of Molecular and Cellular Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 94:9273-8. 1997
    ..In this study, we demonstrate that CTLA-4 is associated with AP50, the medium chain of the clathrin-associated coated pit adaptor protein complex AP2...
  11. ncbi Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif
    H M Craig
    Department of Pathology and, Department of Medicine, San Diego Veterans Affairs Medical Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0679, USA
    Virology 271:9-17. 2000
    ..The interactions with mu1 and mu3 were markedly stronger than the interaction with mu2. Leucine residues of the sorting motif were required for the interactions with mu3 and mu2 and contributed to the ..
  12. pmc A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein
    Rahel Byland
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 18:414-25. 2007
    ....
  13. pmc The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]
    S Wyss
    Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
    J Virol 75:2982-92. 2001
    ..Finally, the C-terminal dileucine was shown to assist the membrane-proximal Y712 motif in restricting the cell surface expression of Env...
  14. ncbi CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles
    Viktor I Korolchuk
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Traffic 3:428-39. 2002
    ..The medium subunit of the AP2 adaptor complex (mu2) is not a substrate for CK2, but is phosphorylated by a second kinase that we show to be cyclin G-associated kinase ..
  15. ncbi CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms
    Jeremy J Rose
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:7413-26. 2005
    ..In contrast, AP-2-mediated enhanced endocytosis constitutes the predominant mechanism for SIV (MAC-239 strain) Nef-induced down-regulation of human CD4 in human cells...
  16. pmc Recruitment of the adaptor protein 2 complex by the human immunodeficiency virus type 2 envelope protein is necessary for high levels of virus release
    Beth Noble
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Virol 80:2924-32. 2006
    ....
  17. doi Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children
    D B Tzitzivacos
    HIV Pathogenesis Research Laboratory, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, Parktown, Johannesburg 2193, South Africa
    AIDS Res Hum Retroviruses 25:1141-8. 2009
    ..For example, LT46 Nef is unable to bind AP-1 and AP-2 and therefore is inactive on CD4 endocytosis. The biological relevance of these findings requires further investigation...
  18. pmc Targeting signals and subunit interactions in coated vesicle adaptor complexes
    L J Page
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, England
    J Cell Biol 131:619-30. 1995
    ..The subunit composition of the plasma membrane adaptor complex is alpha-adaptin, beta-adaptin, AP50, and AP17; while that of the TGN adaptor complex is gamma-adaptin, beta'-adaptin, AP47, and AP19...
  19. pmc Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis
    K G Suresh Kumar
    Department of Animal Biology and 2Mari Lowe Center for Comparative Oncology Research, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 179:935-50. 2007
    ....
  20. ncbi HIV-1 matrix protein: a mysterious regulator of the viral life cycle
    Alissa Bukrinskaya
    D I Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow 123098, RF, Russia
    Virus Res 124:1-11. 2007
    ..It is suggested that two MA fractions possess diverse functions and are involved in different stages of virus morphogenesis as key regulators of the viral life cycle...
  21. ncbi Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2
    S M Morris
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Traffic 2:111-23. 2001
    ..These findings suggest that in addition to previously reported signal-transduction functions, Dab2 could also act as an adaptor protein that may regulate protein trafficking...
  22. pmc Clathrin-mediated endocytosis in AP-2-depleted cells
    Alison Motley
    University of Cambridge, Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
    J Cell Biol 162:909-18. 2003
    We have used RNA interference to knock down the AP-2 mu2 subunit and clathrin heavy chain to undetectable levels in HeLaM cells...
  23. pmc HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses
    Agnès Vendeville
    UMR 5539 CNRS, Département Biologie Santé, Case 107, Universite Montpellier II, 34095 Montpellier Cedex 5, France
    Mol Biol Cell 15:2347-60. 2004
    ..Hence, Tat enters T cells essentially like diphtheria toxin, using clathrin-mediated endocytosis before low-pH-induced and Hsp90-assisted endosomal translocation. Cell responses are then induced from the cytosol...
  24. pmc The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides
    A Pauloin
    INRA, Laboratoire de Biologie Cellulaire et Moleculaire, Centre de Recherche de Jouy, Jouy en Josas, France
    Biochem J 296:409-15. 1993
    b>AP50 is a subunit of the assembly polypeptide (AP) subclass AP-2 from bovine brain coated vesicles. It can be phosphorylated in vivo and in vitro on a threonine residue by means of the AP50 kinase activity associated with AP...
  25. ncbi A structural explanation for the recognition of tyrosine-based endocytotic signals
    D J Owen
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 282:1327-32. 1998
    ..for endocytosis by a cytoplasmic sequence motif, tyrosine-X-X-(hydrophobic residue), that is recognized by the mu2 subunit of AP2 adaptors...
  26. pmc Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef
    Richard S Mitchell
    Department of Medicine, 1 Division of Biology, University of California, San Diego, La Jolla, CA 92093 0679, USA
    J Virol 82:7758-67. 2008
    ..These data indicate that Nef usurps AP-2 complexes to dysregulate Ii trafficking and potentially interfere with antigen presentation in the context of MHC-II...
  27. pmc Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking
    Richard S Mitchell
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    PLoS Pathog 5:e1000450. 2009
    ..Together, the data support a model in which Vpu co-opts the beta-TrCP/SCF E3 ubiquitin ligase complex to induce endosomal trafficking events that remove BST-2 from its site of action as a virion-tethering factor...
  28. ncbi Microarray analysis in the HSV-1 latently infected mouse trigeminal ganglion
    Shiro Higaki
    Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan
    Cornea 23:S42-7. 2004
    ..To review our previous studies regarding alterations in gene expression in HSV-1 latently infected mouse trigeminal ganglia (TGs) following treatment with immunosuppressants and hyperthermia...
  29. ncbi Molecular characterization of the 50- and 57-kDa subunits of the bovine vacuolar proton pump
    Z Zhou
    Division of Molecular Transport, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 273:5878-84. 1998
    ..Biol. Chem. 269, 28509-25815). It has also been reported that the clathrin-coated vesicle proton pump contains AP50, a 50-kDa component of the AP-2 complex responsible for the assembly of clathrin-coated pits, and that AP50 is ..
  30. pmc Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules
    John S L Parker
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 76:4483-96. 2002
    ..When the mu2 proteins derived from T1L and the other laboratory's T3D isolate were expressed after transfection of their cloned ..
  31. ncbi Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew)
    J A Rudd
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T
    Eur J Pharmacol 374:77-84. 1999
    ..p.) or naloxonazine (35 mg/kg, i.p.). This indicates an involvement of mu2-opioid receptors within the brain to mediate the anti-emetic effect of fentanyl...
  32. ncbi Characterization of M-class genome segments of muscovy duck reovirus S14
    Yun Zhang
    Avian Infectious Disease Division of National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, PR China
    Virus Res 125:42-53. 2007
    ..Vero cells, which provides evidence that muA might be functional related to the mammalian reovirus (MRV) mu2. The M2 gene was 2155 nucleotides in length and was predicted to encode muB major outer capsid protein of 676 amino ..
  33. pmc A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 284:32803-12. 2009
    ..Using quantitative endocytosis assays at nerve terminals, we examined how endocytosis depends on the integrity of mu2 function...
  34. ncbi Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2
    W Matsui
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    Biochemistry 29:10791-8. 1990
    ..an AP-2 complex is an asymmetric structure consisting of one large alpha chain, one large beta chain, one medium AP50 chain, and one small AP17 chain. The complex has been shown to contain a core and two appendages...
  35. ncbi Interactions of annexins with the mu subunits of the clathrin assembly proteins
    Carl E Creutz
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Biochemistry 44:13795-806. 2005
    ..In a yeast two-hybrid screen for proteins that interact with the N-terminal domain of annexin A2 we identified the mu2 subunit of the clathrin assembly protein complex AP-2...
  36. doi Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS
    Ting Zhang
    Department of Pharmacognosy, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
    J Ethnopharmacol 117:351-61. 2008
    ....
  37. ncbi Effect of oxidative phosphorylation uncoupler FCCP and F1F0-ATPase inhibitor oligomycin on the electromechanical activity of human myocardium
    D Zablockaite
    Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania
    Adv Med Sci 52:89-93. 2007
    ....
  38. ncbi Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa
    Kenjiro Matsumoto
    Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283 8555, Japan
    Eur J Pharmacol 549:63-70. 2006
    ..The antinociceptive effect of 7-hydroxymitragynine was significantly blocked by the mu1/mu2-opioid receptor antagonist beta-funaltrexamine hydrochloride (beta-FNA) and the mu1-opioid receptor-selective ..
  39. ncbi Antenatal glucocorticoids attenuate activation of the inflammatory reaction and clotting in preterm lambs
    Anneke S Jaarsma
    Department of Pediatrics, University Hospital Groningen, Groningen, The Netherlands
    Biol Neonate 85:82-9. 2004
    ..Blood was used to determine oxygenation index, alveolar - arterial partial O(2) difference (AaDO(2)), AP50 titer (see text), polymorphonuclear leukocytes (PMNs), beta-glucuronidase, thrombin inhibition, activated partial ..
  40. pmc Hydroxide-promoted core conversions of molybdenum-iron-sulfur edge-bridged double cubanes: oxygen-ligated topological PN clusters
    Mark L Hlavinka
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Inorg Chem 46:9192-200. 2007
    ..HQ- affords the clusters [(Tp)2Mo2Fe6S8Q(QH)2](3-) (Q = S, Se) in which HQ- is a terminal ligand and Q(2-) is a mu2-bridging atom in the core...
  41. pmc Sex-limited protein: in vitro and in vivo functions
    F J Beurskens
    Eijkman Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, Utrecht University Hospital, Utrecht, The Netherlands
    Clin Exp Immunol 116:395-400. 1999
    ..C57Bl/6J mice were tested for functional Slp and classical and alternative complement pathway activities (CH50 and AP50 levels, respectively)...
  42. ncbi Signalling through phospholipase C interferes with clathrin-mediated endocytosis
    Nicolas Carvou
    Department of Physiology, University College London, London WC1E 6JJ UK
    Cell Signal 19:42-51. 2007
    ..The two uptake mechanisms were different as only insulin uptake was reduced when the mu2-subunit of the adaptor complex AP-2 was silenced by RNA interference...
  43. ncbi A Synechococcus elongatus PCC 7942 mutant with a higher tolerance toward the herbicide bentazone also confers resistance to sodium chloride stress
    Suvendra N Bagchi
    BioVIII Lehrstuhl für Molekulare Zellphysiologie, Fakultat fur Biologie, Universitat Bielefeld, Universitatsstr 25, Bielefeld, 33615, Germany
    Photosynth Res 92:87-101. 2007
    ..Mutant Mu1 has in part been previously characterized. In the present paper we report on another mutant, called Mu2, which also has a higher tolerance toward bentazone...
  44. ncbi Early activation of inflammation and clotting in the preterm lamb with neonatal RDS: comparison of conventional ventilation and high frequency oscillatory ventilation
    A S Jaarsma
    Department of Pediatrics, Division of Neonatology, University Hospital Groningen, The Netherlands
    Pediatr Res 50:650-7. 2001
    ..minutes after birth and at 2-h intervals thereafter blood samples, from umbilical catheters, were analyzed for AP50 (complement activation), number of polymorphonuclear leukocytes, beta-glucuronidase, platelet function, activated ..
  45. pmc Rotavirus and reovirus modulation of the interferon response
    Barbara Sherry
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Interferon Cytokine Res 29:559-67. 2009
    ..Reovirus likely inhibits the IFN response by at least 3 virus strain-specific mechanisms. First, the reovirus mu2 protein can induce an unusual nuclear accumulation of IRF9 and repress IFN-stimulated gene (ISG) expression, most ..
  46. ncbi Analgesic effects of Tyr-W-MIF-1: a mixed mu2-opioid receptor agonist/mu1-opioid receptor antagonist
    K A Gergen
    Tulane University School of Medicine, New Orleans, LA 70146, USA
    Eur J Pharmacol 316:33-8. 1996
    ..Recently, intrathecal (i.t.) Tyr-W-MIF-1 was shown to induce potent analgesia mediated through spinal mu2-opioid receptors in mice...
  47. ncbi Synthesis, structural characterization, and theoretical studies of gold(I) and gold(I)-gold(III) thiolate complexes: quenching of gold(I) thiolate luminescence
    Manuel Bardají
    Quimica Inorganica, Facultad de Ciencias, Universidad de Valladolid, E 47005 Valladolid, Spain
    Inorg Chem 45:1059-68. 2006
    ..dinuclear or tetranuclear mixed gold(I)-gold(III) derivatives with a thiolate bridge, namely, [(AuPPh3){Au(C6F5)3}(mu2-2-SC6H4NH2)] (4) and [(C6F5)3Au(mu2-2-SC6H4NH2)(AudppmAu)(mu2-2-SC(6)H4NH2)Au(C6F5)3] (5)...
  48. pmc Silencing and complementation of reovirus core protein mu2: functional correlations with mu2-microtubule association and differences between virus- and plasmid-derived mu2
    John Carvalho
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Virology 364:301-16. 2007
    A low-copy component of mammalian reovirus particles is mu2, an 83-kDa protein encoded by the M1 viral genome segment and packaged within the viral core...
  49. ncbi Avian reovirus core protein muA expressed in Escherichia coli possesses both NTPase and RTPase activities
    Yu Pin Su
    Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan
    J Gen Virol 88:1797-805. 2007
    ..acid sequence of core protein muA of avian reovirus has indicated that it may share similar functions to protein mu2 of mammalian reovirus...
  50. ncbi Large tandem duplication associated with a Mu2 insertion in Zea mays B-Peru gene
    L J Harris
    Plant Research Centre, Central Experimental Farm, Agriculture Canada, Ottawa, Ontario
    Plant Mol Biol 25:817-28. 1994
    ..Characterization of relevant regions of b-Perum220 revealed a Mu2 element insertion in one copy of a 534 bp sequence...
  51. pmc Increased ubiquitination and other covariant phenotypes attributed to a strain- and temperature-dependent defect of reovirus core protein mu2
    Cathy L Miller
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    J Virol 78:10291-302. 2004
    ..difference in the morphology of these structures reflects more effective microtubule association by the mu2 core proteins of some viral strains, which form filamentous factories, than by those of others, which form globular ..
  52. ncbi A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptors
    Daisuke Nakayama
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Eur J Pharmacol 563:109-16. 2007
    ..The present results clearly suggest that D-Pro2-Tyr-W-MIF-1 is a selective antagonist for the mu2-opioid receptor in the mouse brain...
  53. ncbi Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine
    C Mullins
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Gen Genet 262:401-12. 1999
    ..sequence tag (EST) database identified orthologs of family members mammalian medium (mu) chain families mu1, mu2, and mu3, of the corresponding AP complexes, and delta-COP, the analogous component of the coatomer (COPI) complex...
  54. ncbi Molecular epidemiology of Candida species isolated from clinical specimens of intensive care unit patients
    Serhat Marol
    Department of Microbiology and Clinical Microbiology, School of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey
    Mycoses 51:40-9. 2008
    ..The strains were typed by random amplified polymorphic DNA (RAPD)-PCR using OPE-03, OPE-18, RP4-2 and AP50-1 primers. In the patients with Candida infections, most isolates exhibited different RAPD patterns. Only three C...
  55. pmc Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120
    D J Stephens
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 335:567-72. 1998
    ..Whereas the wild-type version of the cytosolic domain of TGN38 interacts with highest affinity with mu2, we show that the cytosolic domain of lgp120 interacts almost exclusively with mu3A...
  56. ncbi Orthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces
    Jonghwa Kim
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02115, USA
    Virus Res 101:15-28. 2004
    ..Other evidence indicates that the Orthoreovirus mu2 and Aquareovirus VP5 proteins are homologous, suggesting that VP5 is a core protein as mu2 is known to be...
  57. ncbi Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles
    C Thurieau
    Universite de Paris V, CNRS No 1188, France
    DNA 7:663-9. 1988
    b>AP50 is the 50,000-dalton protein component found in clathrin-coated vesicles as part of the coat assembly protein (AP) complex, AP-2...
  58. ncbi Serine 331 and tyrosine 333 are both involved in the interaction between the cytosolic domain of TGN38 and the mu2 subunit of the AP2 clathrin adaptor complex
    D J Stephens
    Department of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 272:14104-9. 1997
    ..It was recently demonstrated that this motif specifically interacts with the mu2 subunit of the AP2 adaptor complex...
  59. ncbi Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis
    Shawn F Bairstow
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 281:20632-42. 2006
    ..We have discovered a direct interaction between the mu2-subunit of the AP2 complex and PIPKIgamma661 via a yeast two-hybrid screen...
  60. pmc Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1
    Sandra Fausia Soukup
    Functional Genomics Unit, CIC bioGUNE, Derio, Spain
    PLoS Genet 5:e1000532. 2009
    ..Co-localisation of anti-Nec with anti-AP50, Rab5, and Rab7 antibodies establishes that the serpin is processed through multi-vesicular bodies and delivered to ..
  61. ncbi Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex
    Takashi Kanematsu
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka, Japan
    J Neurochem 101:898-905. 2007
    ..The clathrin heavy chain, mu2 and beta2 subunits of AP2 and PRIP-1, were complexed with GABA(A) receptor in brain extract as analyzed by co-..
  62. ncbi Involvement of spinal mu1-opioid receptors on the Tyr-d-Arg-Phe-sarcosine-induced antinociception
    Hirokazu Mizoguchi
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Eur J Pharmacol 540:67-72. 2006
    ..co-treatment with Tyr-D-Pro-Trp-Phe-NH2 (D-Pro2-endomorphin-1) or Tyr-D-Pro-Trp-Gly-NH2 (D-Pro2-Tyr-W-MIF-1), the mu2-opioid receptor antagonists, did not affect the TAPS-induced antinociception...
  63. ncbi The development of the complement system after 28 weeks' gestation
    B Wolach
    Department of Paediatrics, Meir General Hospital, Sapir Medical Center, Kfar Saba, Israel
    Acta Paediatr 86:523-7. 1997
    ..To assess the levels and development of the various complement components in preterm infants, particularly among those born before 34 weeks' gestation...
  64. pmc Comparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolates
    Peng Yin
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, R3E 0W3 Canada
    Virol J 1:6. 2004
    The reovirus M1 genome segment encodes the mu2 protein, a structurally minor component of the viral core, which has been identified as a transcriptase cofactor, nucleoside and RNA triphosphatase, and microtubule-binding protein...
  65. ncbi Anti-complement effects of lactoferrin-derived peptides
    Ørjan Samuelsen
    Department of Medical Microbiology, University Hospital of North Norway, P O Box 56, N 9038 Tromsø, Norway
    FEMS Immunol Med Microbiol 41:141-8. 2004
    ..No inhibitory effect of these peptides was observed on the alternative complement pathway in an AP50 assay...
  66. pmc Inhibition of reovirus by mycophenolic acid is associated with the M1 genome segment
    Laura L Hermann
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 0W3
    J Virol 78:6171-9. 2004
    ..differences in sensitivity to MPA mapped to the viral M1 genome segment, which encodes the minor core protein mu2. MPA also inhibited replication of both strains of reovirus in a variety of other cell lines, including Vero monkey ..
  67. ncbi Bonding trends of thiosemicarbazones in mononuclear and dinuclear copper(I) complexes: syntheses, structures, and theoretical aspects
    Tarlok S Lobana
    Department of Chemistry, Guru Nanak Dev University, Amritsar, India
    Inorg Chem 45:1535-42. 2006
    ..I (5), Br (6), Cl (7), pyridine-2-carbaldehyde thiosemicarbazone (Hpytsc)], (ii) halogen-bridged dimers, [Cu2(mu2-X)2(eta1-S-Htsc)2(Ph3P)2] [X, Htsc = Br (3), Hbtsc; I (8), furan-2-carbaldehyde thiosemicarbazone (Hftsc); I (11), ..
  68. ncbi A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse
    Hiroyuki Watanabe
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    J Pharmacol Exp Ther 312:1075-81. 2005
    ..d-Pro(2)-Tyr-W-MIF-1 may also discriminate between Tyr-W-MIF-1-induced antinociception and the antinociception induced by endomorphin-1 or DAMGO, all of which show a preference for the mu(2)-opioid receptor in the spinal cord...
  69. pmc Recognition of double strand breaks by a mutator protein (MU2) in Drosophila melanogaster
    Raghuvar Dronamraju
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    PLoS Genet 5:e1000473. 2009
    ..A mutation, mu2(a), in Drosophila melanogaster decreases the rate of repair of double strand DNA breaks in oocytes, thus leading to ..
  70. ncbi Gene expression profiling of the early pulmonary response to hyperoxia in mice
    Sandra Perkowski
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, 3850 Spruce Street, Philadelphia, PA 19104 6010, USA
    Am J Respir Cell Mol Biol 28:682-96. 2003
    ..a number of other antioxidant enzymes, including glutathione peroxidase, glutathione-S-Transferase (GST) Pi1, GST mu2, and heme oxygenase-1 showing relatively moderate increases...
  71. ncbi [Anticholinergic effect of procainamide and its sulfonylcarbamide derivatives on electromechanical activity in guinea pig atrium]
    Herta Gurskaite
    Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania
    Medicina (Kaunas) 41:1054-60. 2005
    ..perfusion of atrial strips with Tyrode solution), mean action potential duration measured at 90% (AP90) and 50% (AP50) of repolarization were 92.5+/-4.5 ms and 44.4+/-2.9 ms (n=18), respectively, and contraction force was of 2.7+/-0...
  72. ncbi Photoelectron spectroscopy of free multiply charged Keggin anions alpha-[PM12O40]3- (M = Mo, W) in the gas phase
    Tom Waters
    Department of Physics, Washington State University, 2710 University Drive, Richland, Washington 99354, USA
    J Phys Chem A 110:10737-41. 2006
    ..the highest occupied molecular orbital and other frontier orbitals for PM12O40(3-) are localized primarily on the mu2-oxo bridging ligands of the polyoxometalate framework, consistent with the reactivity on the mu2-oxo sites observed ..
  73. ncbi Interaction of tyrosine-based sorting signals with clathrin-associated proteins
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 269:1872-5. 1995
    ..The interaction was confirmed by in vitro binding assays. Thus, it is likely that the medium chains serve as signal-binding components of the clathrin-dependent sorting machinery...
  74. pmc Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on Bacillus anthracis
    Sherry Kan
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA
    J Bacteriol 195:4355-64. 2013
    ..The Wip1 genome is related to other tectiviruses with Gram-positive hosts, notably, AP50, but displays some interesting differences in its genome organization...
  75. ncbi Formation of dinitrosyl iron complex is a necessary step in the realization of the Na2[Fe2(mu2-S2O3)2(NO)4] 4H2O genetic activity
    S V Vasil'eva
    Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul Kosygina 4, Moscow, 117977 Russia
    Dokl Biol Sci 402:230-2. 2005
  76. ncbi Steric and electronic control over the reactivity of a thiolate-ligated Fe(II) complex with dioxygen and superoxide: reversible mu-oxo dimer formation
    Roslyn M Theisen
    Department of Chemistry, University of Washington, Box 351700, Seattle, Washington 98195 1700, USA
    Inorg Chem 43:7682-90. 2004
    ..Addition of O2 to 1 affords binuclear mu-oxo-bridged [FeIII(SMe2N4(tren))]2(mu2-O)(PF6)2.3MeCN (3)...
  77. pmc Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins
    C Berlioz-Torrent
    CJF 97 03 INSERM, Interactions Moléculaires, Hôte Pathogène, Institut Cochin de Genetique Moleculaire, 75014 Paris, France
    J Virol 73:1350-61. 1999
    ....
  78. ncbi Effect of schistosoma mansoni egg deposition on multiple low doses streptozotocin induced insulin dependent diabetes
    Hala S el-Wakil
    Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
    J Egypt Soc Parasitol 32:987-1002. 2002
    ..51 mu2 +/- 1,567.28) and significantly fewer mean number of beta cells/islets (76.23 +/- 19...
  79. ncbi The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms
    Tal Weizman
    Department of Psychiatry, Tel Aviv Sourasky Medical Center and Tel Aviv University Sackler School of Medicine, Tel Aviv 64239, Israel
    Eur J Pharmacol 478:155-9. 2003
    ..Beta-funaltrexamine (mu1- and mu2-opioid receptor antagonist), naloxonazine (selective mu1-opioid receptor antagonist), naltrindole (selective delta-..
  80. ncbi Decreased desychronisation during self-paced movements in frequency bands involving sensorimotor integration and motor functioning in Parkinson's disease
    Vanessa K Lim
    Department of Psychology, Research Centre for Cognitive Neuroscience, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res Bull 71:245-51. 2006
    ..In contrast, there were significant group differences in the alpha 2 (mu2) and beta 2 frequencies (beta2)...
  81. ncbi Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception
    C D Connelly
    R W Johnson Pharmaceutical Research Institute, Spring House, PA 19477
    Life Sci 54:PL369-74. 1994
    ..c.v.) antinociception in CXBK mice, which are deficient in brain mu1, but not mu2, opioid receptors. CXBK or normal Crl:CD-1 (ICR)BR mice were administered graded doses of etonitazene i.c.v...
  82. ncbi The antinociceptive effect of trazodone in mice is mediated through both mu-opioid and serotonergic mechanisms
    S Schreiber
    Department of Psychiatry C, The Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel
    Behav Brain Res 114:51-6. 2000
    ..by naloxone, beta-FNA and naloxonazine, but not by nor-BNI or naltrindole, implying involvement of mu1- and mu2-opioid mechanisms. When adrenergic and serotonergic antagonists were used, metergoline (p<0...
  83. pmc Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis
    A Nesterov
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    EMBO J 18:2489-99. 1999
    Although interactions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based internalization motifs have been implicated in the selective recruitment of cargo molecules into coated pits, the functional ..
  84. pmc Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9
    Jennifer Zurney
    Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 83:2178-87. 2009
    ..Concordantly, the T1L M1 gene product, mu2, dramatically inhibits IFN-beta-induced reporter gene expression...
  85. ncbi Utilization of the indirect lysosome targeting pathway by lysosome-associated membrane proteins (LAMPs) is influenced largely by the C-terminal residue of their GYXXphi targeting signals
    N R Gough
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Cell Sci 112:4257-69. 1999
    ..of LAMP forms in cells through the indirect pathway is determined by the affinities of their targeting signals, predominantly for the mu2 and mu3 adaptors involved at plasma membrane and endosomal cellular sorting sites, respectively.
  86. ncbi Trafficking of the human transferrin receptor in plant cells: effects of tyrphostin A23 and brefeldin A
    Elena Ortiz-Zapater
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Valencia, Avda Vicente Andres Estelles s n, 46100 Burjassot Valencia, Spain
    Plant J 48:757-70. 2006
    ..A23, which inhibits the interaction between the YTRF endocytosis signal in the hTfR cytosolic tail and the mu2-subunit of the AP2 complex...
  87. ncbi Hereditary properdin deficiency in three families of Tunisian Jews
    M Schlesinger
    Pediatric Department, Barzilai Medical Center, Ashkelon, Israel
    Acta Paediatr 82:744-7. 1993
    ..have been found following analysis of the hemolytic activity of the classical (CH50) and the alternative (AP50) complement pathways in the sera of 101 survivors of meningococcal infections and 59 survivors of severe ..
  88. pmc Identification of functional domains in reovirus replication proteins muNS and mu2
    Takeshi Kobayashi
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Virol 83:2892-906. 2009
    ..RNAi) and reverse genetics to define functional domains in two inclusion-associated proteins, muNS and mu2, which are interacting partners essential for inclusion development and viral replication...
  89. ncbi Clathrin coat construction in endocytosis
    B M Pearse
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK
    Curr Opin Struct Biol 10:220-8. 2000
    ..Recently determined domain structures of other components of the endocytic machinery, particularly the mu2 subunit and the alpha-appendage domain of the AP2 adaptor complex, provide important information on the sequence of ..
  90. ncbi Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1
    Yunden Jinsmaa
    Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Pharmacol Biochem Behav 84:252-8. 2006
    ..Specific opioid antagonists characterized the apparent receptor type: beta-funaltrexamine (mu1/mu2-irreversible antagonist) equally inhibited spinal- and central-mediated antinociception; on the other hand, ..
  91. doi Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma
    Marisa A Gallicchio
    Monash University, Department of Medicine, Alfred Hospital, Commercial Rd, Prahran, 3004, Australia
    Biochim Biophys Acta 1803:919-30. 2010
    ..AGE-BSA increased binding of NKA to the alpha-adaptin but not beta2- or mu2-adaptin subunits of the AP-2 clathrin pit adaptor complex...
  92. ncbi Recruitment of Cdc42 through the GAP domain of RLIP participates in remodeling of the actin cytoskeleton and is involved in Xenopus gastrulation
    Laurent Boissel
    Mécanismes Moléculaires du Développement, Institut Jacques Monod, CNRS UMR 7592, Universités Paris VI et Paris VII, 2 place Jussieu, 75251 Paris Cedex 05, France
    Dev Biol 312:331-43. 2007
    ..We also demonstrate that the complete N-terminal domain of RLIP containing the mu2 binding domain (mu2BD) and the GAP domain induces disruption of the actin cytoskeleton when targeted to the plasma ..
  93. doi Glutathione S-transferase mu2 suppresses cancer cell metastasis in non-small cell lung cancer
    Sheau Chung Tang
    Institute of Medicine, Chung Shan Medical University, Taichung City 40203, Taiwan
    Mol Cancer Res 11:518-29. 2013
    Glutathione S-transferase mu2 (GST-M2) is a phase II detoxification enzyme. Low expression of GST-M2 in lung cancers is due to hypermethylation of its promoter...
  94. pmc Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface
    Dominik Wiemuth
    Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    Biochem J 405:147-55. 2007
    ..We confirm that ENaC is associated with the mu2 subunit of the AP-2 (adaptor protein 2) clathrin adaptor...
  95. doi Chiral transition metal clusters from two enantiomeric schiff base ligands. Synthesis, structures, CD spectra and magnetic properties
    Lin lin Fan
    Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, 510275, China
    Dalton Trans 39:1771-80. 2010
    ..Three L2- link four manganese atoms via the mu2-O,N,O-bridging manner into a MnIIMnIII3 cluster in a distorted tetrahedral geometry...
  96. ncbi Validation of a questionnaire measure of the relative reinforcing value of food
    Gary S Goldfield
    Children s Hospital of Eastern Ontario Research Institute, Mental Health Research, 401 Smyth Rd, Ottawa, ON, Canada K1H 8L1
    Eat Behav 6:283-92. 2005
    ..A significant relationship (Pearson r=0.49, p<0.01; Guttman's MU2=0.69) across the two conditions between the two methods of measuring food reinforcement was observed...
  97. pmc A mega-analysis of genome-wide association studies for major depressive disorder
    Stephan Ripke
    Harvard University Broad Institute, USA
    Mol Psychiatry 18:497-511. 2013
    ..The 3p21.1 MDD-BIP finding should be interpreted with caution as the most significant SNP did not replicate in MDD samples, and genotyping in independent samples will be needed to resolve its status...
  98. doi Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1
    Shukun Luo
    College of Biological Sciences, China Agricultural University, Beijing, China
    FEBS Lett 586:344-9. 2012
    Mutator 2 (MU2) in Drosophila melanogaster has been proposed to be the ortholog of human MDC1, a key mediator in DNA damage response...
  99. ncbi Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor
    G C Rossi
    George C Cotzias Laboratory of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    FEBS Lett 369:192-6. 1995
    ..Inhibition of gastrointestinal transit and spinal morphine analgesia, two mu2 actions, are blocked only by the probe against exon 4 and not by those directed against exon 1...
  100. pmc Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:29549-62. 2007
    ....
  101. pmc Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins
    Sergiy Tyukhtenko
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Biochemistry 47:4160-8. 2008
    ..In addition, we have shown that the juxtamembrane region of L1-CT has some binding affinity to AP2-mu2, although the specificity of this interaction needs further investigation...

Research Grants65

  1. Hepatitis C: E2 Molecular Mechanisms
    Martina Buck; Fiscal Year: 2010
    ..Clathrin-mediated endocytosis (CME), through site-specific phosphorylations of <2(AP50), a subunit of the heterodimeric cargo adaptor AP2, a key regulator of clathrin-mediated receptor endocytosis and ..
  2. BIOCHEMICAL CHARACTERIZATION OF OPIOID BINDING SITES
    Gavril Pasternak; Fiscal Year: 1993
    ..Pharmacological and binding approaches suggest that existence of mu1 and mu2 receptors...
  3. Intracellular mechanisms of reovirus genome replication and particle assembly
    MAX NIBERT; Fiscal Year: 2007
    ..are proposed to be studied insofar as they associate with muNS, with a special emphasis on the viral sigmaNS and mu2 proteins, which have also been implicated in determining features or functions of the factories...
  4. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
    ..shown to be capable of performing fast, accurate and noninvasive measurements of the elastic (mu1) and viscous (mu2) terms of the shear modulus along and across the myofibers of excised myocardium and striated muscle...
  5. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
    ..shown to be capable of performing fast, accurate and noninvasive measurements of the elastic (mu1) and viscous (mu2) terms of the shear modulus along and across the myofibers of excised myocardium and striated muscle...
  6. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2009
    ..Early pharmacological studies have proposed several mu opioid receptor subtypes: mu1, mu2 and morphine-62-glucuronide (M6G)...
  7. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
    ..Early pharmacological studies have proposed several mu opioid receptor subtypes: mu1, mu2 and morphine-62-glucuronide (M6G)...
  8. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
    ..Early pharmacological studies have proposed several mu opioid receptor subtypes: mu1, mu2 and morphine-62-glucuronide (M6G)...
  9. Arrestins in G protein-coupled receptor trafficking
    GREGORY FRALISH; Fiscal Year: 2005
    ..We have recently discovered that a small region of the N-terminus of beta-arrestin2 binds to the mu2-adaptin subunit of AP2...
  10. Research Training in Viral mu2 Localization and Function
    John Carvalho; Fiscal Year: 2006
    ..The mu2 protein, an inner capsid component of reovirus, is suggested to be a regulator of viral cytopathology...
  11. Stoichiometry and modular retrieval of ENaC
    James Stockand; Fiscal Year: 2007
    ..the channel for ubiquitinylation via Nedd4 ubiquitin ligases; and the latter motif is known to interact with the mu2 subunit of the AP-2 complex, which targets proteins for clathrin coated-pit endocytosis mediated by dynamin...
  12. Stoichiometry and modular retrieval of ENaC
    James Stockand; Fiscal Year: 2009
    ..the channel for ubiquitinylation via Nedd4 ubiquitin ligases; and the latter motif is known to interact with the mu2 subunit of the AP-2 complex, which targets proteins for clathrin coated-pit endocytosis mediated by dynamin...
  13. PHARMACOLOGY OF OPIOID RECEPTOR SUBTYPES
    Gavril Pasternak; Fiscal Year: 1993
    ..Furthermore, they act in different regions of the neuroaxis: mu1 and kappa3 supraspinally and mu2, kappa l and delta spinally...
  14. DEVELOPMENT OF RECEPTOR-SPECIFIC OPIOID PEPTIDE ANALOGS
    Peter Schiller; Fiscal Year: 1992
    ..The compound developed might also be useful for the further demonstration of putative opioid subtypes (mu1, mu2, eta1, eta2, eta3, eta4, etc.) and as selective ligands for such subtypes...
  15. MOLECULAR MECHANISMS MEDIATING CD22 ACCESSORY FUNCTION
    LOUIS JUSTEMENT; Fiscal Year: 2003
    ..Additionally, studies performed in this laboratory have determined that CD22 physically interacts with AP50, the medium chain subunit of the AP-2 complex, via a tyrosine-containing motif...
  16. BIOCHEMICAL CHARACTERIZATION OF OPIATE BINDING SITES
    Gavril Pasternak; Fiscal Year: 1991
    ..Recent studies suggest two subtypes of mu receptors. The mu2 site corresponse to the classical morphine- selective mu recePtor previously characterized in peripheral bioassays ..
  17. REGULATION OF ACETYLCHOLINE RECEPTOR EXPRESSION
    Lin Mei; Fiscal Year: 2007
    ..We find that SHP2 binds to ErbB proteins in response to NRG and at the same time interacts with the mu2 subunit ofAP2, a complex implicated in receptor endocytosis...
  18. The role of reovirus factories in viral RNA regulation.
    Cathy Miller; Fiscal Year: 2007
    ....
  19. E3 Ligases and Deubiquitinases in GPCR downregulation
    Sudha Shenoy; Fiscal Year: 2009
    ..abstract_text> ..
  20. E3 Ligases and Deubiquitinases in GPCR Down Regulation
    Sudha K Shenoy; Fiscal Year: 2010
    ....