AP1S3

Summary

Gene Symbol: AP1S3
Description: adaptor-related protein complex 1, sigma 3 subunit
Alias: AP-1 complex subunit sigma-3, adapter-related protein complex 1 sigma-1C subunit, adaptor protein complex AP-1 sigma-1C subunit, clathrin assembly protein complex 1 sigma-1C small chain, golgi adaptor HA1/AP1 adaptin sigma-1C subunit, sigma 1C adaptin, sigma 1C subunit of AP-1 clathrin, sigma-adaptin 1C, sigma1C-adaptin
Species: human

Top Publications

  1. ncbi A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
    P A Bresnahan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco 94141, USA
    Curr Biol 8:1235-8. 1998
  2. ncbi A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
    M Greenberg
    Cold Spring Harbor Laboratory, New York 11724, USA
    Curr Biol 8:1239-42. 1998
  3. ncbi HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes
    Katy Janvier
    Institut Cochin, Department of Infectious Diseases, INSERM U567 CNRS UMR8104, Universite Paris V, 24 rue du Faubourg Saint Jacques, France
    J Biol Chem 278:8725-32. 2003
  4. pmc GGAs: roles of the different domains and comparison with AP-1 and clathrin
    J Hirst
    University of Cambridge, Department of Clinical Biochemistry, Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge CB2 2XY, United Kingdom
    Mol Biol Cell 12:3573-88. 2001
  5. pmc Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
    H M Craig
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 95:11229-34. 1998
  6. pmc Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes
    Scott H Coleman
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0679, USA
    J Virol 79:2066-78. 2005
  7. pmc HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
    Jeremiah F Roeth
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:903-13. 2004
  8. ncbi [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]
    Serge Benichou
    Departement de Maladies Infectieuses, INSERM U 567, CNRS UMR 8104, Institut Cochin, b√Ętiment Gustave Roussy, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Med Sci (Paris) 19:100-6. 2003
  9. ncbi AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast
    T Kirchhausen
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 266:11153-7. 1991
  10. pmc Adaptins: the final recount
    M Boehm
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 12:2907-20. 2001

Scientific Experts

  • Serge Benichou
  • Scott H Coleman
  • Douglas Hitchin
  • Colleen M Noviello
  • John C Guatelli
  • Jeremiah F Roeth
  • Ricardo Madrid
  • Katy Janvier
  • J Hirst
  • M Boehm
  • H M Craig
  • M Greenberg
  • P A Bresnahan
  • John R Day
  • Nanette Van Damme
  • Kathleen L Collins
  • Tracey M Filzen
  • Maya Williams
  • Matthew R Kasper
  • Dan Cassel
  • Louis Renault
  • Jacqueline Cherfils
  • Heather Craig
  • John Guatelli
  • Nathalie Sol-Foulon
  • J S Bonifacino
  • M S Robinson
  • M R Lindsay
  • T Kirchhausen
  • W C Greene
  • I Rapoport
  • R Geleziunas
  • J C Guatelli
  • S Ferrell
  • D Williams-Herman
  • W Yonemoto
  • L DeTulleo
  • M W Pandori
  • J Skowronski
  • S Frucht
  • A C Davis
  • B O Greco
  • B Tubb
  • G S Payne

Detail Information

Publications11

  1. ncbi A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
    P A Bresnahan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco 94141, USA
    Curr Biol 8:1235-8. 1998
    ..Our findings also reveal an evolutionary difference between HIV-1 and HIV-2/SIV in which the Nef proteins utilize structurally distinct motifs for binding cellular adaptors...
  2. ncbi A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
    M Greenberg
    Cold Spring Harbor Laboratory, New York 11724, USA
    Curr Biol 8:1239-42. 1998
    ..Thus, the dileucine motif in HIV-1 is required for CD4 downregulation and for interaction with clathrin adaptor complexes...
  3. ncbi HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes
    Katy Janvier
    Institut Cochin, Department of Infectious Diseases, INSERM U567 CNRS UMR8104, Universite Paris V, 24 rue du Faubourg Saint Jacques, France
    J Biol Chem 278:8725-32. 2003
    ..The stabilization of these complexes on membranes may underlie the pleiotropic effects of Nef on protein trafficking within the endosomal system...
  4. pmc GGAs: roles of the different domains and comparison with AP-1 and clathrin
    J Hirst
    University of Cambridge, Department of Clinical Biochemistry, Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge CB2 2XY, United Kingdom
    Mol Biol Cell 12:3573-88. 2001
    ..Together with results from other studies, our findings suggest that the GGAs act as monomeric adaptors, with the four domains involved in cargo selection, membrane localization, clathrin binding, and accessory protein recruitment...
  5. pmc Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
    H M Craig
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 95:11229-34. 1998
    ..The data also suggest that an influence on the distribution of cellular transmembrane proteins may mechanistically unite two previously distinct properties of Nef: down-regulation of CD4 and enhancement of viral infectivity...
  6. pmc Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes
    Scott H Coleman
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0679, USA
    J Virol 79:2066-78. 2005
    ..This binding likely underlies the unusual ability of Nef to induce the stabilization of these complexes on endosomal membranes, an activity that correlates with enhancement of viral replication...
  7. pmc HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
    Jeremiah F Roeth
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:903-13. 2004
    ..In sum, our evidence suggests that binding of AP-1 to the Nef-MHC-I complex is an important step required for inhibition of antigen presentation by HIV...
  8. ncbi [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]
    Serge Benichou
    Departement de Maladies Infectieuses, INSERM U 567, CNRS UMR 8104, Institut Cochin, b√Ętiment Gustave Roussy, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Med Sci (Paris) 19:100-6. 2003
    ..In addition, these viral factors represent valuable tools to study the pathway they are perturbing...
  9. ncbi AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast
    T Kirchhausen
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 266:11153-7. 1991
    ..The yeast sequence predicts Yap17p, a protein with 147 amino acids and a Mr of 17,373 that is slightly more related to the mammalian AP17 chain than to its AP19 counterpart...
  10. pmc Adaptins: the final recount
    M Boehm
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 12:2907-20. 2001
    ..Finally, we extend our survey to adaptin-related proteins such as the GGAs and stonins, which contain domains homologous to the adaptins...
  11. ncbi HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment
    Scott H Coleman
    Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0679, USA
    Virology 345:148-55. 2006
    ..We conclude that Nef stabilizes AP complexes on endosomal membranes after ARF1-dependent attachment. This stabilization may facilitate coat formation and stimulate the trafficking of multiple cellular proteins...