AP1M1

Summary

Gene Symbol: AP1M1
Description: adaptor-related protein complex 1, mu 1 subunit
Alias: AP47, CLAPM2, CLTNM, MU-1A, AP-1 complex subunit mu-1, AP-mu chain family member mu1A, HA1 47 kDa subunit, adaptor protein complex AP-1 mu-1 subunit, adaptor-related protein complex 1 mu-1 subunit, clathrin adaptor protein AP47, clathrin assembly protein complex 1 medium chain 1, clathrin assembly protein complex 1, medium chain, clathrin assembly protein complex AP1, mu subunit, clathrin coat assembly protein AP47, clathrin coat-associated protein AP47, golgi adaptor AP-1 47 kDa protein, golgi adaptor HA1/AP1 adaptin mu-1 subunit, mu-adaptin 1, mu1A-adaptin
Species: human

Top Publications

  1. ncbi Interaction of tyrosine-based sorting signals with clathrin-associated proteins
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 269:1872-5. 1995
  2. pmc An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex
    Rajendra Kumar Singh
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 4:e8364. 2009
  3. ncbi The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding
    A A Peden
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    J Biol Chem 276:49183-7. 2001
  4. ncbi A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
    P A Bresnahan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco 94141, USA
    Curr Biol 8:1235-8. 1998
  5. pmc HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
    Jeremiah F Roeth
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:903-13. 2004
  6. ncbi Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif
    H M Craig
    Department of Pathology and, Department of Medicine, San Diego Veterans Affairs Medical Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0679, USA
    Virology 271:9-17. 2000
  7. ncbi A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
    M Greenberg
    Cold Spring Harbor Laboratory, New York 11724, USA
    Curr Biol 8:1239-42. 1998
  8. ncbi Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network
    M N Seaman
    Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2QR, United Kingdom
    J Biol Chem 271:25446-51. 1996
  9. pmc Targeting signals and subunit interactions in coated vesicle adaptor complexes
    L J Page
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, England
    J Cell Biol 131:619-30. 1995
  10. ncbi The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
    A Mangasarian
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Immunity 6:67-77. 1997

Scientific Experts

  • Georges Herbein
  • Karen E Reid
  • Serge Benichou
  • Colleen M Noviello
  • Elizabeth R Wonderlich
  • Kathleen L Collins
  • John C Guatelli
  • Deanna A Kulpa
  • Scott H Coleman
  • Katy Janvier
  • C Berlioz-Torrent
  • H M Craig
  • Misoon Park
  • Xiaofei Jia
  • Douglas Hitchin
  • Jolien Vermeire
  • Muthukumar Balasubramaniam
  • H Ohno
  • J Hirst
  • Mary Ann Checkley
  • Eric O Freed
  • Aurelien Dordor
  • Huolin Luo
  • H FOLSCH
  • Nunghathai Sawasdee
  • Yongli Qiao
  • Rajendra Kumar Singh
  • D J Owen
  • R Benarous
  • Cedric Delevoye
  • L Erdtmann
  • Guruprasad R Medigeshi
  • Peter Schu
  • John Guatelli
  • Gregory Camus
  • Nienke B Lubben
  • Maya Williams
  • M S Robinson
  • M Foti
  • A Mangasarian
  • J C Guatelli
  • Seung Y Park
  • Gabriela Lavezzari
  • Jeremiah F Roeth
  • Ricardo Madrid
  • Ina Hinners
  • Viktor I Korolchuk
  • Natasha Del Cid
  • Ulrike Mayer
  • Inhwan Hwang
  • Ilka Reichardt
  • Gerd Jurgens
  • Kyungyoung Song
  • Kirsten A Peterson
  • V Piguet
  • Hyeran Kim
  • York Dieter Stierhof
  • E R Follows
  • Stefanie Homann
  • M N Seaman
  • J L Carpentier
  • Rajendra Singh
  • D Trono
  • G Friocourt
  • A A Peden
  • Yong Xiong
  • HaiTao Yang
  • S Wyss
  • Benjamin G Luttge
  • Bruno Verhasselt
  • J S Bonifacino
  • Kay E Leopold
  • Jason M Norman
  • Heinrich Gottlinger
  • Griet Vanbillemont
  • Wojciech Witkowski
  • Jolie A Leonard
  • Emilie Poudevigne
  • Winfried Weissenhorn
  • Hee Jong Koh
  • Piengpaga Ngaojanlar
  • Zhaolei Liu
  • T Nakagawa
  • Duangporn Ungsupravate
  • Min Seon Choi
  • Sumei Chen
  • E Orzech
  • Pa thai Yenchitsomanus
  • Rihua Piao
  • Nattakan Sukomon

Detail Information

Publications65

  1. ncbi Interaction of tyrosine-based sorting signals with clathrin-associated proteins
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 269:1872-5. 1995
    ..The interaction was confirmed by in vitro binding assays. Thus, it is likely that the medium chains serve as signal-binding components of the clathrin-dependent sorting machinery...
  2. pmc An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex
    Rajendra Kumar Singh
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 4:e8364. 2009
    ..We previously proposed that Nef allows the MHC-I CD to bind the mu subunit of AP-1 (micro1) as if it contained a Yxxphimotif...
  3. ncbi The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding
    A A Peden
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    J Biol Chem 276:49183-7. 2001
    ..Mutation of the di-leucine motif inhibits AP-1 binding in vitro and affects the steady state distribution of VAMP4 in vivo...
  4. ncbi A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
    P A Bresnahan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco 94141, USA
    Curr Biol 8:1235-8. 1998
    ..Our findings also reveal an evolutionary difference between HIV-1 and HIV-2/SIV in which the Nef proteins utilize structurally distinct motifs for binding cellular adaptors...
  5. pmc HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
    Jeremiah F Roeth
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:903-13. 2004
    ..In sum, our evidence suggests that binding of AP-1 to the Nef-MHC-I complex is an important step required for inhibition of antigen presentation by HIV...
  6. ncbi Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif
    H M Craig
    Department of Pathology and, Department of Medicine, San Diego Veterans Affairs Medical Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0679, USA
    Virology 271:9-17. 2000
    ....
  7. ncbi A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
    M Greenberg
    Cold Spring Harbor Laboratory, New York 11724, USA
    Curr Biol 8:1239-42. 1998
    ..Thus, the dileucine motif in HIV-1 is required for CD4 downregulation and for interaction with clathrin adaptor complexes...
  8. ncbi Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network
    M N Seaman
    Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2QR, United Kingdom
    J Biol Chem 271:25446-51. 1996
    ..p80, which is specifically cross-linked to beta'-adaptin; and p60, which is specifically cross-linked to AP47. These proteins are all candidates for components of the adaptor docking site on the trans-Golgi network membrane.
  9. pmc Targeting signals and subunit interactions in coated vesicle adaptor complexes
    L J Page
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, England
    J Cell Biol 131:619-30. 1995
    ..alpha-adaptin, beta-adaptin, AP50, and AP17; while that of the TGN adaptor complex is gamma-adaptin, beta'-adaptin, AP47, and AP19...
  10. ncbi The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
    A Mangasarian
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Immunity 6:67-77. 1997
    ..Taken together, these data suggest that Nef down-regulates CD4 and probably MHC I by physically connecting these receptors with sorting pathways in the Golgi and at the plasma membrane...
  11. pmc Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes
    Katy Janvier
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 163:1281-90. 2003
    ..These observations reveal a novel mode of recognition of sorting signals involving the gamma/delta and sigma subunits of AP-1 and AP-3...
  12. ncbi A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells
    H FOLSCH
    Department of Cell Biology, and Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    Cell 99:189-98. 1999
    ..We conclude that basolateral sorting is mediated by an epithelial cell-specific version of the AP-1 complex containing mu1B...
  13. pmc Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes
    Scott H Coleman
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0679, USA
    J Virol 79:2066-78. 2005
    ..This binding likely underlies the unusual ability of Nef to induce the stabilization of these complexes on endosomal membranes, an activity that correlates with enhancement of viral replication...
  14. pmc Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells
    H FOLSCH
    Department of Cell Biology and Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cell Biol 152:595-606. 2001
    ....
  15. ncbi A structural explanation for the recognition of tyrosine-based endocytotic signals
    D J Owen
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 282:1327-32. 1998
    ..Specificity was conferred by hydrophobic pockets that bind the tyrosine and leucine in the peptide. In the crystal, the protein forms dimers that could increase the strength and specificity of binding to dimeric receptors...
  16. pmc Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
    H M Craig
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 95:11229-34. 1998
    ..The data also suggest that an influence on the distribution of cellular transmembrane proteins may mechanistically unite two previously distinct properties of Nef: down-regulation of CD4 and enhancement of viral infectivity...
  17. ncbi Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex
    L Erdtmann
    INSERM U529, Institut Cochin de Genetique Moleculaire, Universite Paris V, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Traffic 1:871-83. 2000
    ..These data indicate that the recruitment by Nef of AP1 via binding to mu 1 participates in the connection of Nef with the endocytic pathway...
  18. pmc Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes
    V Piguet
    Department of Genetics and Microbiology, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    EMBO J 17:2472-81. 1998
    ..Taken together, these data identify mu adaptins as downstream mediators of the down-modulation of CD4, and possibly MHC I, by Nef...
  19. pmc Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit
    Colleen M Noviello
    University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0679, USA
    J Virol 82:1249-58. 2008
    ..The data support a cooperative binding model in which Nef functions as a clathrin-associated sorting protein that allows recognition of an incomplete, tyrosine-based mu-binding signal in the MHC-I CD by AP-1...
  20. ncbi The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail
    Elizabeth R Wonderlich
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 283:3011-22. 2008
    ..Thus, these data provide evidence that Nef binding to the MHC-I cytoplasmic tail stabilizes the interaction of a tyrosine in the MHC-I cytoplasmic tail with the natural tyrosine binding pocket in AP-1...
  21. ncbi A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex
    T Nakagawa
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    Cell 103:569-81. 2000
    ..Functional blockade of KIF13A reduced cell surface expression of the M6PR. Thus, KIF13A transports M6PR-containing vesicles and targets the M6PR from TGN to the plasma membrane via direct interaction with the AP-1 adaptor complex...
  22. ncbi HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes
    Katy Janvier
    Institut Cochin, Department of Infectious Diseases, INSERM U567 CNRS UMR8104, Universite Paris V, 24 rue du Faubourg Saint Jacques, France
    J Biol Chem 278:8725-32. 2003
    ..The stabilization of these complexes on membranes may underlie the pleiotropic effects of Nef on protein trafficking within the endosomal system...
  23. ncbi Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules
    S Le Gall
    Laboratoire Rétrovirus et Transfert Génétique Unité de Recherche Associée CNRS 1157, Institut Pasteur, Paris, France
    Immunity 8:483-95. 1998
    ..Nef interacts with the medium (mu) subunit of AP adaptor complexes involved in the recognition of tyrosine-based sorting signals, likely facilitating the connection between MHC I and the clathrin-dependent sorting machinery...
  24. pmc GGAs: roles of the different domains and comparison with AP-1 and clathrin
    J Hirst
    University of Cambridge, Department of Clinical Biochemistry, Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge CB2 2XY, United Kingdom
    Mol Biol Cell 12:3573-88. 2001
    ..Together with results from other studies, our findings suggest that the GGAs act as monomeric adaptors, with the four domains involved in cargo selection, membrane localization, clathrin binding, and accessory protein recruitment...
  25. pmc Arabidopsis μ-adaptin subunit AP1M of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth
    Misoon Park
    Entwicklungsgenetik and Microscopy, Zentrum für Molekularbiologie der Pflanzen ZMBP, University of Tubingen, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 110:10318-23. 2013
    ..Here, we report the functional analysis of redundant AP-1 μ-adaptins AP1M1 (also known as muB1) and AP1M2 (also known as muB2)...
  26. ncbi Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 238:305-15. 1997
    ..These observations suggest that HIV-1 Env utilizes the protein sorting machinery of the host cells for internalization and sorting at various steps of the endocytic and biosynthetic pathways...
  27. ncbi Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages
    Georges Herbein
    Department of Virology, University of Franche Comte, Besancon, France
    Curr HIV Res 6:117-29. 2008
    ....
  28. pmc AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1
    Ina Hinners
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO Rep 4:1182-9. 2003
    The R-SNARE VAMP4, which contains a dileucine motif, binds to the AP-1 (adaptor protein-1) subunit mu 1a, but not mu 1b, or the GGAs (Golgi-associated gamma ear containing ARF binding proteins)...
  29. pmc HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation
    Mary Ann Checkley
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, Frederick, MD 21702 1201, USA
    J Mol Biol 410:582-608. 2011
    ..Here, we review our current understanding of HIV-1 Env glycoprotein trafficking and incorporation into virions...
  30. pmc ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells
    Elizabeth R Wonderlich
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Virol 85:12216-26. 2011
    ..These data support a model in which Nef and ARF-1 stabilize an interaction between MHC-I and AP-1 to disrupt the presentation of HIV-1 epitopes to CTLs...
  31. pmc The clathrin adaptor complex AP-1 binds HIV-1 and MLV Gag and facilitates their budding
    Gregory Camus
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique UMR 8104, Paris, France
    Mol Biol Cell 18:3193-203. 2007
    ..We propose that AP-1 promotes Gag release by transporting it to intracellular sites of active budding, and/or by facilitating its interactions with other cellular partners...
  32. pmc AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis
    Cedric Delevoye
    Structure and Membrane Compartments, Centre Nationale de la Recherche Scientifique, UMR 144 Institut Curie, Centre de Recherche, Paris F 75248, France
    J Cell Biol 187:247-64. 2009
    ..Our results reveal that LRO protein sorting is coupled to cell type-specific positioning of endosomes that facilitate endosome-LRO contacts and are required for organelle maturation...
  33. pmc HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2
    Nienke B Lubben
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom
    Mol Biol Cell 18:3351-65. 2007
    ..We propose that depleting AP-2 potentiates Nef activity by altering the membrane composition and dynamics of endosomes and causing increased delivery of HLA-A2 to a prelysosomal compartment...
  34. pmc The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]
    S Wyss
    Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
    J Virol 75:2982-92. 2001
    ..Finally, the C-terminal dileucine was shown to assist the membrane-proximal Y712 motif in restricting the cell surface expression of Env...
  35. pmc Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
    Xiaofei Jia
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Nat Struct Mol Biol 19:701-6. 2012
    ..The structure shows how Nef functions as a clathrin-associated sorting protein to alter the specificity of host membrane trafficking and enable viral evasion of adaptive immunity...
  36. pmc The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection
    Jolien Vermeire
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Belgium
    Curr HIV Res 9:474-89. 2011
    ..Hereby we aim to contribute to a better understanding of this highly conserved and therapeutically attractive Nef function...
  37. doi Essential and supporting host cell factors for HIV-1 budding
    Aurelien Dordor
    Unit of Virus Host Cell Interactions UMI 3265 Université Joseph Fourier EMBL CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
    Future Microbiol 6:1159-70. 2011
    ..Here we review recent advances in understanding the role of host cell factors recruited by Gag during HIV-1 assembly and budding...
  38. pmc New insights into HIV assembly and trafficking
    Muthukumar Balasubramaniam
    Virus Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA
    Physiology (Bethesda) 26:236-51. 2011
    ..In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly...
  39. pmc A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome
    J Hirst
    University of Cambridge, Department of Clinical Biochemistry, Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge CB2 2XY, United Kingdom
    J Cell Biol 149:67-80. 2000
    ..These results indicate that the function of the GGAs is to facilitate the trafficking of proteins between the TGN and the vacuole, or its mammalian equivalent, the lysosome...
  40. pmc Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1
    Deanna A Kulpa
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Virol 87:8085-98. 2013
    ..Thus, we provide evidence for two separable cross-presentation pathways, only one of which is targeted by HIV. ..
  41. ncbi AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin
    Guruprasad R Medigeshi
    Center for Biochemistry and Moleculare Cell Biology, Georg August University Gottingen, Biochemie II, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
    Traffic 9:121-32. 2008
    ..None of the proteins known to influence AP-1 membrane recycling bound to this micro1A domain, indicating the regulation of AP-1 membrane-cytoplasm recycling by an yet unidentified cytoplasmic protein...
  42. doi SPL28 encodes a clathrin-associated adaptor protein complex 1, medium subunit micro 1 (AP1M1) and is responsible for spotted leaf and early senescence in rice (Oryza sativa)
    Yongli Qiao
    Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul, 151 921, Republic of Korea
    New Phytol 185:258-74. 2010
    ..we determined that SPL28 encodes a clathrin-associated adaptor protein complex 1, medium subunit micro 1 (AP1M1), which is involved in the post-Golgi trafficking pathway...
  43. doi Candidate reference genes for gene expression studies in water lily
    Huolin Luo
    Nanjing Agricultural University, Jiangsu, People s Republic of China
    Anal Biochem 404:100-2. 2010
    ..Across all samples, clathrin adaptor complexes medium subunit (AP47) and actin 11 (ACT11) emerged as the most suitable reference genes...
  44. doi Human kidney anion exchanger 1 interacts with adaptor-related protein complex 1 μ1A (AP-1 mu1A)
    Nunghathai Sawasdee
    Division of Medical Molecular Biology and BIOTEC Medical Biotechnology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Biochem Biophys Res Commun 401:85-91. 2010
    ....
  45. pmc Nef-mediated clathrin-coated pit formation
    M Foti
    Department of Morphology, Centre Medical Universitaire, University of Geneva, Switzerland
    J Cell Biol 139:37-47. 1997
    ..e., adaptins). These Nef-generated complexes would then initiate the nucleation of CCP...
  46. pmc An optimized grapevine RNA isolation procedure and statistical determination of reference genes for real-time RT-PCR during berry development
    Karen E Reid
    Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada
    BMC Plant Biol 6:27. 2006
    ..Few statistically validated reference genes have been reported in grapevine. Moreover, success in isolating high quality RNA from grapevine tissues is typically limiting due to low pH, and high polyphenolic and polysaccharide contents...
  47. ncbi unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein
    J Lee
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91106
    Genes Dev 8:60-73. 1994
    ..medium chains of clathrin-associated protein complexes located at the trans-Golgi and the plasma membrane, AP47 and AP50, respectively...
  48. ncbi Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2
    X Wang
    Institut fur Physiologische Chemie, Medizinische Fakultat, Ruhr Universitat Bochum, Germany
    FEBS Lett 402:57-61. 1997
    ..predicted proteins share 60% amino acid sequence identity with each other and 27-31%, identity with mu1-adaptin (ap47) and mu2-adaptin (ap50)...
  49. ncbi Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)
    M Peyrard
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Genomics 50:275-80. 1998
    ..In addition, we localized genes for two other components of the AP-1 adaptor, i.e., the medium (AP47) and small (AP19) subunits, to chromosomes 19 and 7, respectively...
  50. ncbi The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast
    Y Nakayama
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, MA 02115
    Eur J Biochem 202:569-74. 1991
    We have cloned and sequenced mouse brain AP47, the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1...
  51. pmc Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins
    C Berlioz-Torrent
    CJF 97 03 INSERM, Interactions Moléculaires, Hôte Pathogène, Institut Cochin de Genetique Moleculaire, 75014 Paris, France
    J Virol 73:1350-61. 1999
    ....
  52. ncbi Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene
    Y Q Zhang
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Gene 233:171-9. 1999
    ..The two other Drosophila members of the medium-chain family of clathrin-associated protein complexes, AP47 and mu3, have also been identified and mapped to 85D20-D27 and 6E1-E4, respectively.
  53. ncbi Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2)
    F Nakatsu
    Department of Molecular Genetics, Chiba University Graduate School of Medicine, Chiba, Japan
    Cytogenet Cell Genet 87:53-8. 1999
    ..the genomic structure of previously cloned murine genes for mu1B (Ap1m2) and its closely related homolog, mu1A (Ap1m1)...
  54. ncbi Interactions between the exocytic and endocytic pathways in polarized Madin-Darby canine kidney cells
    E Orzech
    Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 275:15207-19. 2000
    ....
  55. ncbi A third specificity-determining site in mu 2 adaptin for sequences upstream of Yxx phi sorting motifs
    D J Owen
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Traffic 2:105-10. 2001
    ..This structure suggests that some sequences can function as a 'three pinned plug', in which internalization activity is not critically dependent on any one of the three interacting side chains...
  56. pmc Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28
    E R Follows
    Enabling Science and Technology, Biology Department, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
    Biochem J 359:427-34. 2001
    ....
  57. ncbi Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system
    G Friocourt
    Laboratoire de Génétique et Physiopathologie des Retards Mentaux, ICGM, INSERM, CHU, Cochin, 24, rue du Faubourg Saint Jacques, Paris, 75014, France
    Mol Cell Neurosci 18:307-19. 2001
    ..Taken together these data indicate that a certain proportion of Doublecortin interacts with AP-1 and/or AP-2 in vivo and are consistent with a potential involvement of Doublecortin in protein sorting or vesicular trafficking...
  58. ncbi Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation
    A Umeda
    Department of Cell Biology, Centre of Anatomy, Hannover Medical School, Germany
    Eur J Cell Biol 79:336-42. 2000
    ..The cellular distribution of membrane-associated adaptors was unaffected by overexpression of GAK. Our results point to a hsc70/auxilin-based uncoating system as a ubiquitous feature of eukaryotic cells...
  59. ncbi CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles
    Viktor I Korolchuk
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Traffic 3:428-39. 2002
    ..In addition, we show that the 'stripped' CCV membranes that remain once the peripheral membrane proteins have been removed from CCVs inhibit CK2 but not GAK/auxilin2 activity...
  60. ncbi [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]
    Serge Benichou
    Departement de Maladies Infectieuses, INSERM U 567, CNRS UMR 8104, Institut Cochin, bâtiment Gustave Roussy, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Med Sci (Paris) 19:100-6. 2003
    ..In addition, these viral factors represent valuable tools to study the pathway they are perturbing...
  61. ncbi EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment
    Seung Y Park
    Department of Biochemistry, College of Medicine, Dongguk University, Kyungju 780 714, Korea
    Biochemistry 43:7552-62. 2004
    ..These findings strongly suggest that EHD2 interacts with GLUT4 in rat adipocytes and may play a key role in insulin-induced GLUT4 recruitment to the plasma membrane...
  62. ncbi Subunit-specific regulation of NMDA receptor endocytosis
    Gabriela Lavezzari
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:6383-91. 2004
    ..Our findings demonstrate fundamental differences between NR2A and NR2B that help clarify developmental changes in NMDA receptor trafficking and surface expression...
  63. ncbi HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment
    Scott H Coleman
    Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0679, USA
    Virology 345:148-55. 2006
    ..We conclude that Nef stabilizes AP complexes on endosomal membranes after ARF1-dependent attachment. This stabilization may facilitate coat formation and stimulate the trafficking of multiple cellular proteins...
  64. ncbi Two rat homologs of clathrin-associated adaptor proteins
    J Pevsner
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical School, CA 94305
    Gene 146:279-83. 1994
    ..80% amino acid (aa) identity to each other and have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles...