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| AP1M1SummaryGene Symbol: AP1M1 Description: adaptor-related protein complex 1, mu 1 subunit Alias: AP47, CLAPM2, CLTNM, MU-1A, AP-1 complex subunit mu-1, AP-mu chain family member mu1A, HA1 47 kDa subunit, adaptor protein complex AP-1 mu-1 subunit, adaptor-related protein complex 1 mu-1 subunit, clathrin adaptor protein AP47, clathrin assembly protein complex 1 medium chain 1, clathrin assembly protein complex 1, medium chain, clathrin assembly protein complex AP1, mu subunit, clathrin coat assembly protein AP47, clathrin coat-associated protein AP47, golgi adaptor AP-1 47 kDa protein, golgi adaptor HA1/AP1 adaptin mu-1 subunit, mu-adaptin 1, mu1A-adaptin Species: human Top Publications
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Publications
Interaction of tyrosine-based sorting signals with clathrin-associated proteinsH Ohno
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Science 269:1872-5. 1995..The interaction was confirmed by in vitro binding assays. Thus, it is likely that the medium chains serve as signal-binding components of the clathrin-dependent sorting machinery...- Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain familyH Ohno
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Virology 238:305-15. 1997..These observations suggest that HIV-1 Env utilizes the protein sorting machinery of the host cells for internalization and sorting at various steps of the endocytic and biosynthetic pathways... 
The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]S Wyss
Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
J Virol 75:2982-92. 2001..Finally, the C-terminal dileucine was shown to assist the membrane-proximal Y712 motif in restricting the cell surface expression of Env...- A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4M Greenberg
Cold Spring Harbor Laboratory, New York 11724, USA
Curr Biol 8:1239-42. 1998..Thus, the dileucine motif in HIV-1 is required for CD4 downregulation and for interaction with clathrin adaptor complexes... - A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptorP A Bresnahan
Gladstone Institute of Virology and Immunology, University of California, San Francisco 94141, USA
Curr Biol 8:1235-8. 1998..Our findings also reveal an evolutionary difference between HIV-1 and HIV-2/SIV in which the Nef proteins utilize structurally distinct motifs for binding cellular adaptors... - A structural explanation for the recognition of tyrosine-based endocytotic signalsD J Owen
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Science 282:1327-32. 1998..Specificity was conferred by hydrophobic pockets that bind the tyrosine and leucine in the peptide. In the crystal, the protein forms dimers that could increase the strength and specificity of binding to dimeric receptors... - The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 bindingA A Peden
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5345, USA
J Biol Chem 276:49183-7. 2001..Mutation of the di-leucine motif inhibits AP-1 binding in vitro and affects the steady state distribution of VAMP4 in vivo... - A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cellsH FOLSCH
Department of Cell Biology, and Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
Cell 99:189-98. 1999..We conclude that basolateral sorting is mediated by an epithelial cell-specific version of the AP-1 complex containing mu1B... - Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexesKaty Janvier
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 163:1281-90. 2003..These observations reveal a novel mode of recognition of sorting signals involving the gamma/delta and sigma subunits of AP-1 and AP-3... - Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexesScott H Coleman
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0679, USA
J Virol 79:2066-78. 2005..This binding likely underlies the unusual ability of Nef to induce the stabilization of these complexes on endosomal membranes, an activity that correlates with enhancement of viral replication... - Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motifH M Craig
Department of Pathology and, Department of Medicine, San Diego Veterans Affairs Medical Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0679, USA
Virology 271:9-17. 2000.... - A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complexT Nakagawa
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
Cell 103:569-81. 2000..Functional blockade of KIF13A reduced cell surface expression of the M6PR. Thus, KIF13A transports M6PR-containing vesicles and targets the M6PR from TGN to the plasma membrane via direct interaction with the AP-1 adaptor complex... - Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complexL Erdtmann
INSERM U529, Institut Cochin de Genetique Moleculaire, Universite Paris V, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
Traffic 1:871-83. 2000..These data indicate that the recruitment by Nef of AP1 via binding to mu 1 participates in the connection of Nef with the endocytic pathway... - Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivityH M Craig
Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0679, USA
Proc Natl Acad Sci U S A 95:11229-34. 1998..The data also suggest that an influence on the distribution of cellular transmembrane proteins may mechanistically unite two previously distinct properties of Nef: down-regulation of CD4 and enhancement of viral infectivity... - Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunitColleen M Noviello
University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0679, USA
J Virol 82:1249-58. 2008..The data support a cooperative binding model in which Nef functions as a clathrin-associated sorting protein that allows recognition of an incomplete, tyrosine-based mu-binding signal in the MHC-I CD by AP-1... - AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesisCedric Delevoye
Structure and Membrane Compartments, Centre Nationale de la Recherche Scientifique, UMR 144 Institut Curie, Centre de Recherche, Paris F 75248, France
J Cell Biol 187:247-64. 2009..Our results reveal that LRO protein sorting is coupled to cell type-specific positioning of endosomes that facilitate endosome-LRO contacts and are required for organelle maturation... - HIV-1 Nef stabilizes the association of adaptor protein complexes with membranesKaty Janvier
Institut Cochin, Department of Infectious Diseases, INSERM U567 CNRS UMR8104, Universite Paris V, 24 rue du Faubourg Saint Jacques, France
J Biol Chem 278:8725-32. 2003..The stabilization of these complexes on membranes may underlie the pleiotropic effects of Nef on protein trafficking within the endosomal system... - Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cellsH FOLSCH
Department of Cell Biology and Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Cell Biol 152:595-606. 2001.... - Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I moleculesS Le Gall
Laboratoire Rétrovirus et Transfert Génétique Unité de Recherche Associée CNRS 1157, Institut Pasteur, Paris, France
Immunity 8:483-95. 1998..Nef interacts with the medium (mu) subunit of AP adaptor complexes involved in the recognition of tyrosine-based sorting signals, likely facilitating the connection between MHC I and the clathrin-dependent sorting machinery... - GGAs: roles of the different domains and comparison with AP-1 and clathrinJ Hirst
University of Cambridge, Department of Clinical Biochemistry, Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge CB2 2XY, United Kingdom
Mol Biol Cell 12:3573-88. 2001..Together with results from other studies, our findings suggest that the GGAs act as monomeric adaptors, with the four domains involved in cargo selection, membrane localization, clathrin binding, and accessory protein recruitment... - Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexesV Piguet
Department of Genetics and Microbiology, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
EMBO J 17:2472-81. 1998..Taken together, these data identify mu adaptins as downstream mediators of the down-modulation of CD4, and possibly MHC I, by Nef... - AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1Ina Hinners
Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
EMBO Rep 4:1182-9. 2003The R-SNARE VAMP4, which contains a dileucine motif, binds to the AP-1 (adaptor protein-1) subunit mu 1a, but not mu 1b, or the GGAs (Golgi-associated gamma ear containing ARF binding proteins)... - Targeting signals and subunit interactions in coated vesicle adaptor complexesL J Page
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, England
J Cell Biol 131:619-30. 1995..alpha-adaptin, beta-adaptin, AP50, and AP17; while that of the TGN adaptor complex is gamma-adaptin, beta'-adaptin, AP47, and AP19... - HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tailJeremiah F Roeth
Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
J Cell Biol 167:903-13. 2004..In sum, our evidence suggests that binding of AP-1 to the Nef-MHC-I complex is an important step required for inhibition of antigen presentation by HIV... - The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membraneA Mangasarian
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Immunity 6:67-77. 1997..Taken together, these data suggest that Nef down-regulates CD4 and probably MHC I by physically connecting these receptors with sorting pathways in the Golgi and at the plasma membrane... - Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi networkM N Seaman
Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2QR, United Kingdom
J Biol Chem 271:25446-51. 1996..p80, which is specifically cross-linked to beta'-adaptin; and p60, which is specifically cross-linked to AP47. These proteins are all candidates for components of the adaptor docking site on the trans-Golgi network membrane. - [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]Serge Benichou
Departement de Maladies Infectieuses, INSERM U 567, CNRS UMR 8104, Institut Cochin, bâtiment Gustave Roussy, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
Med Sci (Paris) 19:100-6. 2003..In addition, these viral factors represent valuable tools to study the pathway they are perturbing... - EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitmentSeung Y Park
Department of Biochemistry, College of Medicine, Dongguk University, Kyungju 780 714, Korea
Biochemistry 43:7552-62. 2004..These findings strongly suggest that EHD2 interacts with GLUT4 in rat adipocytes and may play a key role in insulin-induced GLUT4 recruitment to the plasma membrane... - Subunit-specific regulation of NMDA receptor endocytosisGabriela Lavezzari
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 24:6383-91. 2004..Our findings demonstrate fundamental differences between NR2A and NR2B that help clarify developmental changes in NMDA receptor trafficking and surface expression... - HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachmentScott H Coleman
Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0679, USA
Virology 345:148-55. 2006..We conclude that Nef stabilizes AP complexes on endosomal membranes after ARF1-dependent attachment. This stabilization may facilitate coat formation and stimulate the trafficking of multiple cellular proteins... - An optimized grapevine RNA isolation procedure and statistical determination of reference genes for real-time RT-PCR during berry developmentKaren E Reid
Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada
BMC Plant Biol 6:27. 2006..Few statistically validated reference genes have been reported in grapevine. Moreover, success in isolating high quality RNA from grapevine tissues is typically limiting due to low pH, and high polyphenolic and polysaccharide contents... - AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptinGuruprasad R Medigeshi
Center for Biochemistry and Moleculare Cell Biology, Georg August University Gottingen, Biochemie II, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
Traffic 9:121-32. 2008..None of the proteins known to influence AP-1 membrane recycling bound to this micro1A domain, indicating the regulation of AP-1 membrane-cytoplasm recycling by an yet unidentified cytoplasmic protein... 
SPL28 encodes a clathrin-associated adaptor protein complex 1, medium subunit micro 1 (AP1M1) and is responsible for spotted leaf and early senescence in rice (Oryza sativa)Yongli Qiao
Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul, 151 921, Republic of Korea
New Phytol 185:258-74. 2010..we determined that SPL28 encodes a clathrin-associated adaptor protein complex 1, medium subunit micro 1 (AP1M1), which is involved in the post-Golgi trafficking pathway...- Candidate reference genes for gene expression studies in water lilyHuolin Luo
Nanjing Agricultural University, Jiangsu, People s Republic of China
Anal Biochem 404:100-2. 2010..Across all samples, clathrin adaptor complexes medium subunit (AP47) and actin 11 (ACT11) emerged as the most suitable reference genes... - Human kidney anion exchanger 1 interacts with adaptor-related protein complex 1 μ1A (AP-1 mu1A)Nunghathai Sawasdee
Division of Medical Molecular Biology and BIOTEC Medical Biotechnology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Biochem Biophys Res Commun 401:85-91. 2010.... - CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesiclesViktor I Korolchuk
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Traffic 3:428-39. 2002..In addition, we show that the 'stripped' CCV membranes that remain once the peripheral membrane proteins have been removed from CCVs inhibit CK2 but not GAK/auxilin2 activity... - Two rat homologs of clathrin-associated adaptor proteinsJ Pevsner
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical School, CA 94305
Gene 146:279-83. 1994..80% amino acid (aa) identity to each other and have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles... - unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated proteinJ Lee
Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91106
Genes Dev 8:60-73. 1994..medium chains of clathrin-associated protein complexes located at the trans-Golgi and the plasma membrane, AP47 and AP50, respectively... - Nef-mediated clathrin-coated pit formationM Foti
Department of Morphology, Centre Medical Universitaire, University of Geneva, Switzerland
J Cell Biol 139:37-47. 1997..e., adaptins). These Nef-generated complexes would then initiate the nucleation of CCP... - Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)M Peyrard
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Genomics 50:275-80. 1998..In addition, we localized genes for two other components of the AP-1 adaptor, i.e., the medium (AP47) and small (AP19) subunits, to chromosomes 19 and 7, respectively... - Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteinsC Berlioz-Torrent
CJF 97 03 INSERM, Interactions Moléculaires, Hôte Pathogène, Institut Cochin de Genetique Moleculaire, 75014 Paris, France
J Virol 73:1350-61. 1999.... - Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 geneY Q Zhang
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
Gene 233:171-9. 1999..The two other Drosophila members of the medium-chain family of clathrin-associated protein complexes, AP47 and mu3, have also been identified and mapped to 85D20-D27 and 6E1-E4, respectively. - Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2)F Nakatsu
Department of Molecular Genetics, Chiba University Graduate School of Medicine, Chiba, Japan
Cytogenet Cell Genet 87:53-8. 1999..the genomic structure of previously cloned murine genes for mu1B (Ap1m2) and its closely related homolog, mu1A (Ap1m1)... - Interactions between the exocytic and endocytic pathways in polarized Madin-Darby canine kidney cellsE Orzech
Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
J Biol Chem 275:15207-19. 2000.... - Identification of the universal cofactor (auxilin 2) in clathrin coat dissociationA Umeda
Department of Cell Biology, Centre of Anatomy, Hannover Medical School, Germany
Eur J Cell Biol 79:336-42. 2000..The cellular distribution of membrane-associated adaptors was unaffected by overexpression of GAK. Our results point to a hsc70/auxilin-based uncoating system as a ubiquitous feature of eukaryotic cells... - Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2X Wang
Institut fur Physiologische Chemie, Medizinische Fakultat, Ruhr Universitat Bochum, Germany
FEBS Lett 402:57-61. 1997..predicted proteins share 60% amino acid sequence identity with each other and 27-31%, identity with mu1-adaptin (ap47) and mu2-adaptin (ap50)... - A third specificity-determining site in mu 2 adaptin for sequences upstream of Yxx phi sorting motifsD J Owen
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Traffic 2:105-10. 2001..This structure suggests that some sequences can function as a 'three pinned plug', in which internalization activity is not critically dependent on any one of the three interacting side chains... - Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28E R Follows
Enabling Science and Technology, Biology Department, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
Biochem J 359:427-34. 2001.... - Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous systemG Friocourt
Laboratoire de Génétique et Physiopathologie des Retards Mentaux, ICGM, INSERM, CHU, Cochin, 24, rue du Faubourg Saint Jacques, Paris, 75014, France
Mol Cell Neurosci 18:307-19. 2001..Taken together these data indicate that a certain proportion of Doublecortin interacts with AP-1 and/or AP-2 in vivo and are consistent with a potential involvement of Doublecortin in protein sorting or vesicular trafficking... - The medium chains of the mammalian clathrin-associated proteins have a homolog in yeastY Nakayama
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, MA 02115
Eur J Biochem 202:569-74. 1991We have cloned and sequenced mouse brain AP47, the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1...