ANTXR2

Summary

Gene Symbol: ANTXR2
Description: anthrax toxin receptor 2
Alias: CMG-2, CMG2, HFS, ISH, JHF, anthrax toxin receptor 2, capillary morphogenesis gene 2 protein, capillary morphogenesis protein 2
Species: human
Products:     ANTXR2

Top Publications

  1. Chen C, Zhang X, Wang Y. ANTXR2 and IL-1R2 polymorphisms are not associated with ankylosing spondylitis in Chinese Han population. Rheumatol Int. 2012;32:15-9 pubmed publisher
    Strong associations between the polymorphisms of anthrax toxin receptor 2 (ANTXR2) and interleukin-1 receptor 2 (IL-1R2) and ankylosing spondylitis (AS) were identified through genome-wide scan by Australo-Anglo-American Spondyloarthritis ..
  2. Evans D, Spencer C, Pointon J, Su Z, Harvey D, Kochan G, et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet. 2011;43:761-7 pubmed publisher
    ..P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each ..
  3. Denadai R, Raposo Amaral C, Bertola D, Kim C, Alonso N, HART T, et al. Identification of 2 novel ANTXR2 mutations in patients with hyaline fibromatosis syndrome and proposal of a modified grading system. Am J Med Genet A. 2012;158A:732-42 pubmed publisher
    ..rare, autosomal recessive disorders of the connective tissue caused by mutations in the gene encoding the anthrax toxin receptor 2 protein (ANTXR2) located on chromosome 4q21...
  4. Dowling O, Difeo A, Ramirez M, Tukel T, Narla G, Bonafe L, et al. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003;73:957-66 pubmed
    ..we identified and characterized JHF and ISH disease-causing mutations in the capillary morphogenesis factor-2 gene (CMG2)...
  5. Bell S, Mavila A, Salazar R, Bayless K, Kanagala S, Maxwell S, et al. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J Cell Sci. 2001;114:2755-73 pubmed
    ..These data further elucidate the genetic events regulating capillary tube formation in a 3D matrix environment. ..
  6. Scobie H, Rainey G, Bradley K, Young J. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A. 2003;100:5170-4 pubmed
    ..In this report, we identify a second PA receptor encoded by capillary morphogenesis gene 2 (CMG2), which has 60% amino acid identity to ATR/TEM8 within the VWA/I domain, as well as a conserved MIDAS motif...
  7. Lacy D, Wigelsworth D, Scobie H, Young J, Collier R. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proc Natl Acad Sci U S A. 2004;101:6367-72 pubmed
    ..been shown to bind to two cellular receptors: anthrax toxin receptor/tumor endothelial marker 8 and capillary morphogenesis protein 2 (CMG2)...
  8. Lacy D, Wigelsworth D, Melnyk R, Harrison S, Collier R. Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A. 2004;101:13147-51 pubmed publisher
    ..We present an example of a receptor negatively regulating pH-dependent membrane insertion...
  9. Abrami L, Leppla S, van der Goot F. Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. J Cell Biol. 2006;172:309-20 pubmed

More Information

Publications114 found, 100 shown here

  1. Deuquet J, Abrami L, Difeo A, Ramirez M, Martignetti J, van der Goot F. Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum. Hum Mutat. 2009;30:583-9 pubmed publisher
    ..infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF), which are caused by mutations in the CMG2 gene...
  2. Abrami L, Liu S, Cosson P, Leppla S, van der Goot F. Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J Cell Biol. 2003;160:321-8 pubmed
    ..e., slow endocytosis as a monomer and rapid clathrin-mediated uptake on clustering, make it an ideal anthrax toxin receptor. ..
  3. Hanks S, Adams S, Douglas J, Arbour L, Atherton D, Balci S, et al. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003;73:791-800 pubmed
    ..We now report the identification of 15 different mutations in the gene encoding capillary morphogenesis protein 2 (CMG2) in 17 families with JHF or ISH...
  4. Wigelsworth D, Krantz B, Christensen K, Lacy D, Juris S, Collier R. Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J Biol Chem. 2004;279:23349-56 pubmed
    ..Two PA receptors, anthrax toxin receptor (ATR)/tumor endothelial marker 8 (TEM8) and capillary morphogenesis protein 2 (CMG2), have been identified...
  5. Santelli E, Bankston L, Leppla S, Liddington R. Crystal structure of a complex between anthrax toxin and its host cell receptor. Nature. 2004;430:905-8 pubmed publisher
    ..Two closely related host cell receptors, TEM8 and CMG2, have been identified. Both bind to PA with high affinity and are capable of mediating toxicity...
  6. Scobie H, Young J. Divalent metal ion coordination by residue T118 of anthrax toxin receptor 2 is not essential for protective antigen binding. PLoS ONE. 2006;1:e99 pubmed
    ..subunit of anthrax toxin interacts with the integrin-like I domains of either of two cellular receptors, ANTXR1 or ANTXR2. These I domains contain a metal ion-dependent adhesion site (MIDAS) made up of five non-consecutive amino acid ..
  7. Reveille J, Sims A, Danoy P, Evans D, Leo P, Pointon J, et al. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet. 2010;42:123-7 pubmed publisher
    ..9 x 10(-19)) and 21q22 (rs2242944; P = 8.3 x 10(-20)), as well as in the genes ANTXR2 (rs4333130; P = 9.3 x 10(-8)) and IL1R2 (rs2310173; P = 4.8 x 10(-7))...
  8. Abrami L, Kunz B, van der Goot F. Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake. Proc Natl Acad Sci U S A. 2010;107:1420-4 pubmed publisher
    ..Consistently, we found that uptake of the anthrax toxin and processing of the lethal factor substrate MEK1 are inhibited by silencing of src and fyn, as well as in src and fyn knockout cells. ..
  9. Guo C, Xia Y, Yang Q, Qiu R, Zhao H, Liu Q. Association of the ANTXR2 gene polymorphism and ankylosing spondylitis in Chinese Han. Scand J Rheumatol. 2012;41:29-32 pubmed publisher
    ..Both genetic and environmental factors are involved. A recent genome-wide association study (GWAS) found anthrax toxin receptor 2 (ANTXR2) to be associated with AS in Caucasians...
  10. Abrami L, Lindsay M, Parton R, Leppla S, van der Goot F. Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol. 2004;166:645-51 pubmed
  11. Lee J, Tsai Y, Chao S, Tu Y. Capillary morphogenesis gene-2 mutation in infantile systemic hyalinosis: ultrastructural study and mutation analysis in a Taiwanese infant. Clin Exp Dermatol. 2005;30:176-9 pubmed
    ..Recent studies identified pathogenic mutations in the capillary morphogenesis gene 2 (CMG2) in both ISH and juvenile hyaline fibromatosis (JHF)...
  12. Deuquet J, Lausch E, Guex N, Abrami L, Salvi S, Lakkaraju A, et al. Hyaline fibromatosis syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors. EMBO Mol Med. 2011;3:208-21 pubmed publisher
    Hyaline Fibromatosis Syndrome (HFS) is a human genetic disease caused by mutations in the anthrax toxin receptor 2 (or cmg2) gene, which encodes a membrane protein thought to be involved in the homeostasis of the extracellular matrix...
  13. Atzpodien E, Jacobsen B, Funk J, Altmann B, Silva Munoz M, Singer T, et al. Advanced Clinical Imaging and Tissue-based Biomarkers of the Eye for Toxicology Studies in Minipigs. Toxicol Pathol. 2016;44:398-413 pubmed publisher
    ..coherence tomography (OCT) techniques and of ocular relevant immunohistochemistry (IHC) or in situ hybridization (ISH) markers to porcine eyes...
  14. Wan Y, Kang G, Sreenivasan C, Daharsh L, Zhang J, Fan W, et al. A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus. J Virol. 2018;92: pubmed publisher
    ..To our knowledge, this is the first study showing that a DNA vaccine expressing consensus HEF is efficacious in preventing different lineages of IDV infections. ..
  15. Ni K, Dansranjavin T, Rogenhofer N, Oeztuerk N, Deuker J, Bergmann M, et al. TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility. Hum Reprod. 2016;31:1411-24 pubmed publisher
    ..Testis sections were used for in situ hybridization (ISH) and immunohistochemical (IHC) studies to determine TET1-3 mRNA and protein expression, and for immunofluorescence (..
  16. Guo J, Song W, Boulanger J, Xu E, Wang F, Zhang Y, et al. Dysregulated Expression of microRNA-21 and Disease Related Genes in Human Patients and Mouse Model of Alport Syndrome. Hum Gene Ther. 2019;: pubmed publisher
    ..They were evaluated for miR-21 expression by qPCR and in situ hybridization (ISH) and mRNA expression by qPCR...
  17. Novosel D, Cadar D, Tuboly T, Jungić A, Stadejek T, Ait Ali T, et al. Investigating porcine parvoviruses genogroup 2 infection using in situ polymerase chain reaction. BMC Vet Res. 2018;14:163 pubmed publisher
    ..syndrome virus (PRRSV), swine influenza (SIV), Mycoplasma hyopneumoniae (Mhyo); and by in situ hybridization (ISH) to detect ssDNA and dsDNA of PCV2...
  18. Geßner A, Borkowetz A, Baier M, Göhlert A, Wilhelm T, Thumbs A, et al. Detection of HPV16 in Esophageal Cancer in a High-Incidence Region of Malawi. Int J Mol Sci. 2018;19: pubmed publisher
    ..HPV DNA was detected using multiplex Quantitative PCR (qPCR) and in situ hybridization (ISH). p16INK4a staining served as a surrogate marker for HPV oncogene activity...
  19. Ros E, López Miranda J, Picó C, Rubio M, Babio N, Sala Vila A, et al. [CONSENSUS ON FATS AND OILS IN THE DIET OF S ISH ADULTS; POSITION PAPER OF THE SPANISH FEDERATION OF FOOD, NUTRITION AND DIETETICS SOCIETIES]. Nutr Hosp. 2015;32:435-77 pubmed publisher
    ..El límite de. ..
  20. Bethea C, Phu K, Kim A, Reddy A. Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques. Neuroscience. 2015;301:576-89 pubmed publisher
    ..In the dorsal raphe, MAO-A and MAO-B expressions were determined with in situ hybridization (ISH) and protein expression of aromatase was determined with immunohistochemistry (IHC)...
  21. Lu Y, Yu J, Yang Z, Zhu G, Gao P, Wang H, et al. Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC). J Exp Clin Cancer Res. 2018;37:301 pubmed publisher
    ..The expression levels of miR-10b-3p in ESCC specimens were analyzed by in situ hybridization (ISH) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays...
  22. Layh Schmitt G, Lu S, Navid F, Brooks S, Lazowick E, Davis K, et al. Generation and differentiation of induced pluripotent stem cells reveal ankylosing spondylitis risk gene expression in bone progenitors. Clin Rheumatol. 2017;36:143-154 pubmed publisher
    ..We show for the first time, that expression levels of several AS susceptibility genes (EDIL3, ANO6, HAPLN1, ANTXR2) involved in bone formation are significantly elevated in MSCs (2-15-fold; p ? 0...
  23. Fan L, Jiang J, Gao J, Song H, Liu J, Yang L, et al. Identification and Characterization of a PRDM14 Homolog in Japanese Flounder (Paralichthys olivaceus). Int J Mol Sci. 2015;16:9097-118 pubmed publisher
    ..Results of real-time quantitative polymerase chain reaction amplification (RT-qPCR) and in situ hybridization (ISH) in embryos demonstrated that Po-prdm14 was highly expressed between the morula and late gastrula stages, with its ..
  24. Chong Y, Kang C. Causative agents of Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis): a meta-analysis. Int J Pediatr Otorhinolaryngol. 2014;78:1890-7 pubmed publisher
    ..diagnosed KFD and normal controls by polymerase chain reaction (PCR) or in situ hybridization (ISH) were carefully retrieved...
  25. Qureishi A, Mawby T, Fraser L, Shah K, Møller H, Winter S. Current and future techniques for human papilloma virus (HPV) testing in oropharyngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2017;274:2675-2683 pubmed publisher
    ..45 studies were identified and included. p16 immunohistochemistry (IHC), HPV DNA in situ hybridization (ISH) and HPV polymerase chain reaction (PCR) are the commonest tests to determine HPV status...
  26. Zhang L, Ren M, Song G, Liu X, Zhang J, Wang J. [Genetic and prenatal diagnosis of a pregnant women with mental retardation]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016;33:674-7 pubmed publisher
    ..3,+ish mar D15Z1+ SNRPN+[82]/46,XX,del18q21.3[18]. Whole genome DNA microarray confirmed that a 3...
  27. Lurbe E, Torro M, Alvarez Pitti J, Redon P, Redon J. Central blood pressure and pulse wave amplification across the spectrum of peripheral blood pressure in overweight and obese youth. J Hypertens. 2016;34:1389-95 pubmed publisher
    ..The largest differences between office SBP and central SBP correspond to the isolated systolic hypertension (ISH) group, in which only 25% of patients have high cBP, in contrast to 50% of the systo-diastolic hypertension (SDH) ..
  28. Stanisavljević L, Myklebust M, Leh S, Dahl O. LGR5 and CD133 as prognostic and predictive markers for fluoropyrimidine-based adjuvant chemotherapy in colorectal cancer. Acta Oncol. 2016;55:1425-1433 pubmed
    ..LGR5 mRNA and CD133 expression were assessed by in situ hybridization (ISH) and immunohistochemistry (IHC), respectively...
  29. Vanden Heuvel G, Payne J, Igarashi P, Forbush B. Expression of the basolateral Na-K-Cl cotransporter during mouse nephrogenesis and embryonic development. Gene Expr Patterns. 2006;6:1000-6 pubmed
    ..of Slc12a2 (NKCC1) transcripts in the developing mouse by Northern blot analysis and in situ hybridization (ISH) using riboprobes transcribed from a cDNA encoding the transmembrane domain of human Slc12a2...
  30. Stanisavljević L, Aßmus J, Storli K, Leh S, Dahl O, Myklebust M. CXCR4, CXCL12 and the relative CXCL12-CXCR4 expression as prognostic factors in colon cancer. Tumour Biol. 2016;37:7441-52 pubmed publisher
    ..Immunohistochemistry (IHC) and in situ hybridization (ISH) were used to study CXCR4, CXCL12 and relative CXCL12-CXCR4 expression in tissue microarrays...
  31. Zargar Shoshtari K, Spiess P, Berglund A, Sharma P, Powsang J, Giuliano A, et al. Clinical Significance of p53 and p16(ink4a) Status in a Contemporary North American Penile Carcinoma Cohort. Clin Genitourin Cancer. 2016;14:346-51 pubmed publisher
    ..HPV in situ hybridization (ISH) for high-risk subtypes was also performed...
  32. Karikalan M, Rajukumar K, Mishra N, Kumar M, Kalaiyarasu S, Rajesh K, et al. Distribution pattern of bovine viral diarrhoea virus type 1 genome in lymphoid tissues of experimentally infected sheep. Vet Res Commun. 2016;40:55-61 pubmed publisher
    ..Tissues collected from ten mock-infected lambs served as controls. In situ hybridization (ISH) was carried out in paraformaldehyde fixed paraffin embedded tissue sections using digoxigenin labelled riboprobe ..
  33. Fatema K, Rahman B, Zwar N, Milton A, Ali L. Short-term predictive ability of selected cardiovascular risk prediction models in a rural Bangladeshi population: a case-cohort study. BMC Cardiovasc Disord. 2016;16:105 pubmed publisher
    ..The present study was undertaken to test the hypothesis that both laboratory-based (Framingham equation and WHO/ISH laboratory-based charts) and non-laboratory-based tools may be used to predict CVDs on a short-term basis...
  34. Chen C, Chen M, Chang S, Hung F, Lee M, Chern S, et al. Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 2. Taiwan J Obstet Gynecol. 2017;56:234-237 pubmed publisher
    ..b>ish der(2)(D2Z+)[10]. The sSMC was derived from the ? satellite of chromosome 2...
  35. Soares R, Maglieri G, Gutschner T, Diederichs S, Lund A, Nielsen B, et al. Evaluation of fluorescence in situ hybridization techniques to study long non-coding RNA expression in cultured cells. Nucleic Acids Res. 2017;: pubmed publisher
    ..RNAs (lncRNAs) is facilitated by visualization of their subcellular localization using in situ hybridization (ISH) techniques...
  36. Krasuska Sławińska E, Polnik D, Rokicki D, Koeber B. Treatment of Massive Labial and Gingival Hypertrophy in a Patient With Infantile Systemic Hyalinosis-A Case Report. J Oral Maxillofac Surg. 2015;73:1962.e1-5 pubmed publisher
    Infantile systemic hyalinosis (ISH) is a rare autosomal recessive disorder caused by a mutation in the ANTXR2 gene encoding a transmembranous protein involved in endothelial development...
  37. Lee Y, Lin C, Jeng C, Chang H, Chang C, Pang V. The pathogenic role of torque teno sus virus 1 and 2 and their correlations with various viral pathogens and host immunocytes in wasting pigs. Vet Microbiol. 2015;180:186-95 pubmed publisher
    ..respectively, were used for the detection of TTSuV1, TTSuV2, PCV2, PRRSV, and PPV by either in situ hybridization (ISH) or immunohistochemical (IHC) staining, and for the detection of various subsets of immunocytes by IHC staining ..
  38. Zhang W, Hubbard A, Pang L, Parkinson L, Brunhoeber P, Wang Y, et al. Protecting Quantum Dot Fluorescence from Quenching to Achieve a Reliable Automated Multiplex Fluorescence In Situ Hybridization Assay. J Biomed Nanotechnol. 2015;11:1583-96 pubmed
    ..QDs represent an ideal detection material for in situ hybridization (ISH) because they may provide unprecedented resolution and strong signal intensities that are not attainable with ..
  39. Fontes M, Santos A, Molck M, Simioni M, Nascimento D, Andrade A, et al. Genotype-phenotype correlation of 16p13.3 terminal duplication and 22q13.33 deletion: Natural history of a patient and review of the literature. Am J Med Genet A. 2016;170:766-72 pubmed publisher
    ..After genomic array and FISH analysis, the karyotype was 46,XX,ins(22;16)(q13;p13.2p13.3). ish ins(22;16)(RP11-35P16+, RP11-27M24+). arr16p13.2p13.3(85,880-9,413,353)×3 dn arr22q13...
  40. Zhou J, Li X, Wu M, Lin C, Guo Y, Tian B. Knockdown of Long Noncoding RNA GHET1 Inhibits Cell Proliferation and Invasion of Colorectal Cancer. Oncol Res. 2016;23:303-9 pubmed publisher
    ..We analyzed the expression of GHET1 in colorectal cancer (CRC) tissues by using ISH. We found that GHET1 expression was significantly increased in the CRC samples compared with adjacent tissues...
  41. Koh H, Aimoto M, Matsuhisa A, Inoue S, Katayama T, Okamura H, et al. Combinational approach using in situ hybridization targeting 23S ribosomal RNA genes and blood cultures for bacterial identification in patients with neutropenia and fever. J Infect Chemother. 2016;22:697-703 pubmed publisher
    A new 23S ribosomal RNA genes-targeted in situ hybridization (ISH) probe to detect global bacterial genomic DNA (59 species from 35 genera; referred to as the GB probe) phagocytized in leukocytes was recently developed...
  42. Shishido K, Antoniadis A, Takahashi S, Tsuda M, Mizuno S, Andreou I, et al. Effects of Low Endothelial Shear Stress After Stent Implantation on Subsequent Neointimal Hyperplasia and Clinical Outcomes in Humans. J Am Heart Assoc. 2016;5: pubmed publisher
    In-stent hyperplasia (ISH) may develop in regions of low endothelial shear stress (ESS), but the relationship between the magnitude of low ESS, the extent of ISH, and subsequent clinical events has not been investigated...
  43. Fambrini M, Salvini M, Pugliesi C. Molecular cloning, phylogenetic analysis, and expression patterns of LATERAL SUPPRESSOR-LIKE and REGULATOR OF AXILLARY MERISTEM FORMATION-LIKE genes in sunflower (Helianthus annuus L.). Dev Genes Evol. 2017;227:159-170 pubmed publisher
    ..In situ hybridization (ISH) analysis showed that Ha-ROXL transcription was strongly restricted to a small domain within the boundary zone ..
  44. Volpi C, Ciniselli C, Gualeni A, Plebani M, Alfieri S, Verderio P, et al. In situ hybridization detection methods for HPV16 E6/E7 mRNA in identifying transcriptionally active HPV infection of oropharyngeal carcinoma: an updating. Hum Pathol. 2018;74:32-42 pubmed publisher
    The aim of this study is to compare 2 in situ hybridization (ISH) detection methods for human papilloma virus (HPV) 16 E6/E7 mRNA, that is, the RNAscope 2.0 High Definition (HD) and the upgraded RNAscope 2.5 HD version. The RNAscope 2...
  45. Rajapaksha M, Lovell S, Janowiak B, Andra K, Battaile K, Bann J. pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2. Protein Sci. 2012;21:1467-80 pubmed publisher
    The anthrax protective antigen (PA) binds to the host cellular receptor capillary morphogenesis protein 2 (CMG2) with high affinity...
  46. Song C, Liu L, Pei X, Liu X, Yang L, Ye F, et al. miR-200c inhibits breast cancer proliferation by targeting KRAS. Oncotarget. 2015;6:34968-78 pubmed publisher
    ..In situ hybridization (ISH) and microarrays showed that low miR-200c expression was associated with poor patient overall survival (OS) and ..
  47. Sun J, Jacquez P. Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation. Toxins (Basel). 2016;8:34 pubmed publisher
    ..As the major receptor for anthrax toxin in vivo, anthrax toxin receptor 2 (ANTXR2) plays an essential role in anthrax toxin action by providing the toxin with a high-affinity ..
  48. Viesser R, Ducati L, Autschbach J, Tormena C. NMR spin-spin coupling constants: bond angle dependence of the sign and magnitude of the vicinal (3)JHF coupling. Phys Chem Chem Phys. 2016;18:24119-28 pubmed publisher
    ..One of the fluorine lone pairs, ?C?'-HF, ?C?-F, ?C?'-C?' bonding orbitals and the ?*C?-F antibonding orbital are involved in the J-coupling pathways, according to analyses of pairwise-steric and hyperconjugative energies. ..
  49. Zhang Y, Xiang C, Wang Y, Duan Y, Liu C, Jin Y, et al. lncRNA LINC00152 knockdown had effects to suppress biological activity of lung cancer via EGFR/PI3K/AKT pathway. Biomed Pharmacother. 2017;94:644-651 pubmed publisher
    ..In our present study, we firstly evaluated lncRNA LINC00152 and EGFR expressions by ISH or IHC methods, and analyzed the correlation between LINC00152 and EGFR with RT-PCR...
  50. Sonou A, Ogoudjobi M, Adjagba P, Houehanou C, Aniglé R, Codjo L, et al. Absolute cardiovascular risk of women using hormonal contraception in Porto-Novo. Cardiovasc J Afr. 2018;29:e1-e4 pubmed publisher
    ..The determination of ACVR was dual based on the World Health Organisation (WHO/ISH) and the European Society of Cardiology (ESC/ESH) models. The mean age of the women was 35.3 ± 8.2 years...
  51. Park C, Kang H, Jeong J, Kang I, Choi K, Yoo M, et al. In-situ Hybridization for the Detection of Sacbrood Virus in Infected Larvae of the Honey Bee (Apis cerana). J Comp Pathol. 2016;154:258-62 pubmed publisher
    The aim of this study was to develop and use in-situ hybridization (ISH) for the detection and localization of the sacbrood virus (SBV) in Korean honey bee (Apis cerana) larvae that were infected naturally with SBV...
  52. Laiho J, Oikarinen M, Richardson S, Frisk G, Nyalwidhe J, Burch T, et al. Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. J Clin Virol. 2016;77:21-8 pubmed publisher
    ..This study evaluates the relative sensitivity of immunohistochemistry (IHC), proteomics, in situ hybridization (ISH) and RT-PCR to detect one common EV, Coxsackievirus B1 (CVB1), in acutely infected human A549 cells in vitro...
  53. Wang S, Liu Y, Zhang Z, Wang Z, Xu Y, Wang Z. Temporal and spatial expression profiles of Frizzled 3 in the ovary during the estrous cycle. Genet Mol Res. 2016;15: pubmed publisher
    ..of Frizzled 3 mRNA and protein during the estrous cycle in the mouse ovary through in situ hybridization (ISH), real-time quantitative polymerase chain reaction, immunohistochemistry and western blot...
  54. Link J, Benavente R, Alsheimer M. Analysis of Meiotic Telomere Behavior in the Mouse. Methods Mol Biol. 2016;1411:195-208 pubmed publisher
    ..We also present a protocol for detection of telomeric DNA at the electron microscopic level (EM-ISH)...
  55. Yakkioui Y, Speel E, van Overbeeke J, Boderie M, Pujari S, Hausen A, et al. Oncogenic Viruses in Skull Base Chordomas. World Neurosurg. 2018;112:e7-e13 pubmed publisher
    ..Immunohistochemistry (IHC) and in situ hybridization (ISH) were used to validate the positive results...
  56. Tavares C, Melo M, Cameselle Teijeiro J, Soares P, Sobrinho Simões M. ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome. Eur J Endocrinol. 2016;174:R117-26 pubmed publisher
    ..detected by molecular methods in surgically resected specimens, thus ruling out immunohistochemistry and (F)ISH, despite their crucial relevance as topographically oriented methods...
  57. Park J, Yoon D, Kim S, Park J, Park C, Sung H, et al. Pretreatment whole blood Epstein-Barr virus-DNA is a significant prognostic marker in patients with Hodgkin lymphoma. Ann Hematol. 2016;95:801-8 pubmed publisher
    ..EBV-DNA(+) may be a significant predictor of inferior EFS and OS over EBV-encoded RNA in situ hybridization (EBER-ISH)(+) in Korean patients with HL...
  58. Cheah P, Koh C, Nazarina A, Teoh K, Looi L. Correlation of p16INK4a immunoexpression and human papillomavirus (HPV) detected by in-situ hybridization in cervical squamous neoplasia. Malays J Pathol. 2016;38:33-8 pubmed
    ..assess the correlation between hrHPV detection using a commercial in-situ hybridization assay (Ventana INFORM HPV ISH) and p16 immunoexpression (CINtec Histology Kit) in cervical squamous intraepithelial lesions and squamous ..
  59. Chen K, Liu S, Leysath C, Miller Randolph S, Zhang Y, Fattah R, et al. Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting. J Biol Chem. 2016;291:22021-22029 pubmed
    ..Two PA receptors are known, with capillary morphogenesis protein 2 (CMG2) being the more important for pathogenesis and tumor endothelial marker 8 (TEM8) playing a ..
  60. Ferdinand K. Update in pharmacologic treatment of hypertension. Cardiol Clin. 2001;19:279-94, v pubmed
    ..CCBs are alternative agents for ISH in the elderly and appear to decrease stroke with perhaps less protection against progression of renal ..
  61. Bates T, Kennedy M, Diajil A, Goodson M, Thomson P, Doran E, et al. Changes in Epidermal Growth Factor Receptor Gene Copy Number during Oral Carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2016;25:927-35 pubmed publisher
    ..EGFR GCN was examined by in situ hybridization (ISH) in biopsies from 78 patients with OPMD and 92 patients with early-stage (stages I and II) OSCC...
  62. Wang Y, Zhang J, Ding Y, Zhang M, Liu J, Ma J, et al. Prevalence of Hypertension among Adults in Remote Rural Areas of Xinjiang, China. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..Hypertension was defined according to WHO/ISH criteria. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the population were (126.3 ± 21...
  63. Aishah A, Hinton T, Machaalani R. Cellular protein and mRNA expression of ?1 nicotinic acetylcholine receptor (nAChR) subunit in brain, skeletal muscle and placenta. Int J Dev Neurosci. 2017;58:9-16 pubmed publisher
    ..1 nAChR subunit in the brain, at both the mRNA and protein levels, using non-radioactive in situ hybridization (ISH) and immunohistochemistry (IHC), respectively, and to compare it to two muscle tissue types, skeletal and placenta...
  64. Mineshige T, Kamiie J, Sugahara G, Shirota K. A study on periostin involvement in the pathophysiology of canine atopic skin. J Vet Med Sci. 2017;: pubmed publisher
    ..Using double-labeled in situ hybridization (ISH), interleukin (IL)-13 mRNA-positive cells were detected near the keratinocytes and dermal fibroblasts expressing PO ..
  65. Xia Y, Chen K, Zhang M, Wang L, Ma C, Lin Y, et al. MicroRNA-124 involves in ankylosing spondylitis by targeting ANTXR2. Mod Rheumatol. 2015;25:784-9 pubmed publisher
    A recent genome-wide association study or GWAS identified that anthrax roxin receptor 2 (ANTXR2) was one of the risk loci for ankylosing spondylitis (AS). Previous study also showed that ANTXR2 could potentially affect new bone formation...
  66. Covach A, Patel S, Hardin H, Lloyd R. Phosphorylated Mechanistic Target of Rapamycin (p-mTOR) and Noncoding RNA Expression in Follicular and Hürthle Cell Thyroid Neoplasm. Endocr Pathol. 2017;28:207-212 pubmed publisher
    ..Tissue microarrays (TMAs) with archived tissue samples were analyzed using in situ hybridization (ISH) for MALAT1 and miR-885 and immunohistochemistry (IHC) for p-mTOR...
  67. Atia M, Adawy S, El Itriby H. Date Palm Sex Differentiation Based on Fluorescence In Situ Hybridization (FISH). Methods Mol Biol. 2017;1638:245-256 pubmed publisher
    In situ hybridization (ISH) is used to visualize defined DNA sequences in cellular preparations by hybridization of complementary probe sequences...
  68. Amasdl S, Smaili W, Natiq A, Hassani A, Sbiti A, Agadr A, et al. Familial X/Y Translocation Encompassing ARSE in Two Moroccan Siblings with Sensorineural Deafness. Cytogenet Genome Res. 2017;: pubmed publisher
    ..The final karyotype of the probands was: 46,Y,der(X),t(X;Y)(p22;q12).ish der(X)(DXYS129-,DXYS153-)mat.arr[hg19] Xp22.33(61091_2689408)×1mat,Xp22.33(2701273_3258404)×0mat,Yq11...
  69. Wei W, Lu Q, Chaudry G, Leppla S, Cohen S. The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin. Cell. 2006;124:1141-54 pubmed
    ..showed that LRP6 enables toxin internalization by interacting at the cell surface with PA receptors TEM8/ATR and/or CMG2 to form a multicomponent complex that enters cells upon PA binding...
  70. Ko Y, Kim N, Pyo J. Concordance analysis between HER2 immunohistochemistry and in situ hybridization in non-small cell lung cancer. Int J Biol Markers. 2017;: pubmed publisher
    ..between human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) and in situ hybridization (ISH) and the diagnostic accuracy of HER2 IHC in non-small cell lung cancer (NSCLC) through a meta-analysis and ..
  71. Radtke A, Cremers J, Kliesch S, Riek S, Junker K, Mohamed S, et al. Can germ cell neoplasia in situ be diagnosed by measuring serum levels of microRNA371a-3p?. J Cancer Res Clin Oncol. 2017;143:2383-2392 pubmed publisher
    ..four orchiectomy specimens of patients with GCT were examined immunohistochemically and by in situ hybridization (ISH) with a probe specific for miR-371a-3p to look for the presence of this miR in GCNis cells...
  72. Mai W, Lu D, Liu X, Chen L. MCP-1 produced by keratinocytes is associated with leucocyte recruitment during elicitation of nickel-induced occupational allergic contact dermatitis. Toxicol Ind Health. 2017;:748233717738633 pubmed publisher
    ..time points were assessed by immunohistochemistry (IHC) for MCP-1, CD68, CD45RO, and in situ hybridization (ISH) for MCP-1, using chronic periumbilical dermititis as controls...
  73. El Kamah G, Fong K, El Ruby M, Afifi H, Clements S, Lai Cheong J, et al. Spectrum of mutations in the ANTXR2 (CMG2) gene in infantile systemic hyalinosis and juvenile hyaline fibromatosis. Br J Dermatol. 2010;163:213-5 pubmed publisher
  74. Dennis M, Mogridge J. A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation. Biochemistry. 2014;53:2166-71 pubmed publisher
    ..The interaction between PA and anthrax toxin receptor 1 (ANTXR1) is weaker than its interaction with ANTXR2 such that the pH threshold of ANTXR1-mediated pore formation is higher by 1 pH unit...
  75. Arévalo M, Navarro A, Arico C, Li J, Alkhatib O, Chen S, et al. Targeted silencing of anthrax toxin receptors protects against anthrax toxins. J Biol Chem. 2014;289:15730-8 pubmed publisher
    ..toxins enter cells via two identified anthrax toxin receptors: tumor endothelial marker 8 (TEM8) and capillary morphogenesis protein 2 (CMG2)...
  76. Ye L, Sun P, Sanders A, Martin T, Lane J, Mason M, et al. Therapeutic potential of capillary morphogenesis gene 2 extracellular vWA domain in tumour?related angiogenesis. Int J Oncol. 2014;45:1565-73 pubmed publisher
    Capillary morphogenesis gene 2 (CMG2) is a receptor of anthrax toxin and plays an important role in angiogenesis...
  77. Friebe S, Deuquet J, van der Goot F. Differential dependence on N-glycosylation of anthrax toxin receptors CMG2 and TEM8. PLoS ONE. 2015;10:e0119864 pubmed publisher
    ANTXR 1 and 2, also known as TEM8 and CMG2, are two type I membrane proteins, which have been extensively studied for their role as anthrax toxin receptors, but with a still elusive physiological function...
  78. Tsimploulis A, Sheriff H, Lam P, Dooley D, Anker M, Papademetriou V, et al. Systolic-diastolic hypertension versus isolated systolic hypertension and incident heart failure in older adults: Insights from the Cardiovascular Health Study. Int J Cardiol. 2017;235:11-16 pubmed publisher
    Isolated systolic hypertension (ISH) is common in older adults and is a risk factor for incident heart failure (HF). We examined the association of systolic-diastolic hypertension (SDH) with incident HF and other outcomes in older adults...
  79. Monavarfeshani A, Knill C, Sabbagh U, Su J, Fox M. Region- and Cell-Specific Expression of Transmembrane Collagens in Mouse Brain. Front Integr Neurosci. 2017;11:20 pubmed publisher
    ..e., collagens XIII, XVII, XXIII and XXV) in mouse brain. Using quantitative PCR and in situ hybridization (ISH), we demonstrate both region- and cell-specific expression of these unique collagens in the developing brain...
  80. Cao S, Huang J, Chen J, Hu Y, Hu X, Ren T, et al. Long non-coding RNA UBE2CP3 promotes tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. Oncotarget. 2017;8:65370-65385 pubmed publisher
    ..samples as assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and in situ hybridization (ISH) experiments...
  81. Johannessen C, Moi L, Kiselev Y, Pedersen M, Dalen S, Braaten T, et al. Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer. PLoS ONE. 2017;12:e0186658 pubmed publisher
    ..Further, in situ hybridization (ISH) was used to study the cellular and subcellular distribution of the miRNAs...
  82. Wang J, Duan L, Gao Y, Zhou S, Liu Y, Wei S, et al. Angiotensin II receptor blocker valsartan ameliorates cardiac fibrosis partly by inhibiting miR-21 expression in diabetic nephropathy mice. Mol Cell Endocrinol. 2018;472:149-158 pubmed publisher
    ..In this study, In Situ Hybridization(ISH), RT-PCR, cell transfection, western blotting and laser confocal telescope were used, respectively...
  83. Karaderi T, Keidel S, Pointon J, Appleton L, Brown M, Evans D, et al. Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2). Ann Rheum Dis. 2014;73:2054-8 pubmed publisher
    b>ANTXR2 variants have been associated with ankylosing spondylitis (AS) in two previous genome-wide association studies (GWAS) (p∼9×10(-8)). However, a genome-wide significant association (p<5×10(-8)) was not observed...
  84. Fuentes Mattei E, Giza D, Shimizu M, Ivan C, Manning J, Tudor S, et al. Plasma Viral miRNAs Indicate a High Prevalence of Occult Viral Infections. EBioMedicine. 2017;20:182-192 pubmed publisher
    ..Finally, we identified the viral miRNAs by in situ hybridization (ISH) in bone marrow cells...
  85. Chen C, Chen M, Wu C, Lin C, Chern S, Wu P, et al. Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 21q11.2-q21.1 and a literature review. Taiwan J Obstet Gynecol. 2017;56:554-557 pubmed publisher
    ..Metaphase fluorescence in situ hybridization analysis on cultured amniocytes revealed a result of 47,XX,+mar .ish der(13/21) (D13/21Z1+) [10]. Spectral karyotyping analysis determined the origin of chromosome 21 in the sSMC...
  86. Ercolani C, Marchio C, Di Benedetto A, Fabi A, Perracchio L, Vici P, et al. Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification. J Exp Clin Cancer Res. 2017;36:143 pubmed publisher
    ..In this context, our data indicate that MLPA may be a reliable, objective supporting test in selecting HER2 positive breast cancer patients. ..
  87. Rabouille C. Detection of mRNA and Associated Molecules by ISH-IEM on Frozen Sections. Methods Mol Biol. 2018;1649:177-186 pubmed publisher
    ..by the tag detection with specific antibodies and gold conjugates form the core of the in situ hybridization (ISH)-immunoelectron microscopy (IEM) method that we have developed and successfully used to detect endogenous gurken ..
  88. Rahvar M, Teng J, Kim J. Systemic Hyalinosis With Heterozygous CMG2 Mutations: A Case Report and Review of Literature. Am J Dermatopathol. 2016;38:e60-3 pubmed publisher
    ..Here, the authors present a case of systemic hyalinosis with a heterozygous mutation in CMG2 that resulted in improved survival.
  89. Bouzalas I, Wüthrich D, Selimovic Hamza S, Drögemüller C, Bruggmann R, Seuberlich T. Full-genome based molecular characterization of encephalitis-associated bovine astroviruses. Infect Genet Evol. 2016;44:162-168 pubmed publisher
    ..Molecular testing by a combination of reverse transcription (RT-) PCR and in situ hybridization (ISH) indicated that astrovirus infection accounts for around one quarter of viral encephalitis cases of unknown ..
  90. Weli S, Dale O, Hansen H, Gjessing M, Rønneberg L, Falk K. A case study of Desmozoon lepeophtherii infection in farmed Atlantic salmon associated with gill disease, peritonitis, intestinal infection, stunted growth, and increased mortality. Parasit Vectors. 2017;10:370 pubmed publisher
    ..To characterize the disease outbreak, a combination of histopathology, in situ hybridization (ISH), chitin, calcofluor-white (CFW) staining, and real-time PCR were used to describe the disease progression with ..
  91. Usui S, Ebinuma H, Chu P, Nakamoto N, Yamagishi Y, Saito H, et al. Detection of bacterial DNA by in situ hybridization in patients with decompensated liver cirrhosis. BMC Gastroenterol. 2017;17:106 pubmed publisher
    ..In situ hybridization (ISH) was previously developed for rapid detection of genes from bacteria phagocytized by neutrophils...