antichymotrypsin

Summary

Gene Symbol: antichymotrypsin
Description: serpin family A member 3
Alias: AACT, ACT, GIG24, GIG25, alpha-1-antichymotrypsin, cell growth-inhibiting gene 24/25 protein, growth-inhibiting protein 24, growth-inhibiting protein 25, serine (or cysteine) proteinase inhibitor, clade A, member 3, serpin A3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Species: human
Products:     antichymotrypsin

Top Publications

  1. Poller W, Faber J, Weidinger S, Tief K, Scholz S, Fischer M, et al. A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. Genomics. 1993;17:740-3 pubmed
    ..and direct sequencing of amplified genomic DNA, we have identified two defective mutants of the human alpha 1-antichymotrypsin (ACT) gene associated with chronic obstructive pulmonary disease (COPD)...
  2. Obach V, Revilla M, Vila N, Cervera A A, Chamorro A A. alpha(1)-antichymotrypsin polymorphism: a risk factor for hemorrhagic stroke in normotensive subjects. Stroke. 2001;32:2588-91 pubmed
    ..Preliminary data showed that the TT genotype of the alpha(1)-antichymotrypsin (ACT) gene polymorphism was associated with HS, although it remained unsettled whether prevalence of this ..
  3. Fu Y, Xie R, Wang Y, Chen D, Zhang Y, Wang G, et al. [Association between alpha-1-antichymotrypsin gene polymorphism and cerebral hemorrhage]. Zhonghua Yi Xue Za Zhi. 2002;82:915-7 pubmed
    To explore the association between alpha-1-antichymotrypsin (ACT) gene A/T polymorphism and cerebral hemorrhage among Chinese people...
  4. Slowik A, Borratynska A, Turaj W, Pera J, Dziedzic T, Figlewicz D, et al. Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage. Stroke. 2005;36:737-40 pubmed
    The member 3 of clade A of serine proteinase inhibitors (SERPINA3), known previously as the alpha1-antichymotrypsin, is an acute phase protein, the levels of which increase in acute and chronic inflammation...
  5. Chappell S, Daly L, Morgan K, Guetta Baranes T, Roca J, Rabinovich R, et al. Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Hum Mutat. 2006;27:103-9 pubmed
    ..In contrast, no haplotype associations for SERPINA3 were identified. ..
  6. Pera J, Slowik A, Dziedzic T, Szczudlik A. SERPINA3 polymorphism is not associated with primary intracerebral hemorrhage in a Polish population. Stroke. 2006;37:906-7 pubmed
    ..We failed to find an association between SERPINA3 A/T polymorphism and PICH in a Polish population. ..
  7. Krischek B, Akagawa H, Tajima A, Narita A, Kasuya H, Hori T, et al. The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population. Cerebrovasc Dis. 2007;23:46-9 pubmed
    Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G...
  8. DeMeo D, Campbell E, Barker A, Brantly M, Eden E, McElvaney N, et al. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol. 2008;38:114-20 pubmed
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency. ..
  9. Hu C, Sung S, Liu H, Hsu W, Lee L, Lee C, et al. Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan. J Neurol Sci. 2000;181:127-31 pubmed
    ..gene (A2M G2998A), low-density lipoprotein receptor-related protein gene (LRP, C766T), and alpha(1)-antichymotrypsin gene (ACT, -15Ala/Thr) in AD patients and non-affected elder individuals among Taiwanese Chinese...

More Information

Publications131 found, 100 shown here

  1. Kroczynska B, Evangelista C, Samant S, Elguindi E, Blond S. The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity. J Biol Chem. 2004;279:11432-43 pubmed
    ..Here we describe the cloning of the human homologue HTJ1 and its interaction with alpha(1)-antichymotrypsin (ACT), a member of the serine proteinase inhibitor (serpin) family...
  2. Ligibel J, Meyerhardt J, Pierce J, Najita J, Shockro L, Campbell N, et al. Impact of a telephone-based physical activity intervention upon exercise behaviors and fitness in cancer survivors enrolled in a cooperative group setting. Breast Cancer Res Treat. 2012;132:205-13 pubmed publisher
    ..The Active After Cancer Trial (AACT) was a multicenter pilot study evaluating the feasibility of a telephone-based exercise intervention in a ..
  3. Ashtiani M, Zandi M, Barzin J, Tahamtani Y, Ghanian M, Moradmand A, et al. Substrate-mediated commitment of human embryonic stem cells for hepatic differentiation. J Biomed Mater Res A. 2016;104:2861-72 pubmed publisher
    ..expression levels of the endodermal markers SOX17, FOXA2, and CXCR4, compared with physically adsorbed Act (aAct) or without Act (noAct)...
  4. Frenette G, Deperthes D, Tremblay R, Lazure C, Dube J. Purification of enzymatically active kallikrein hK2 from human seminal plasma. Biochim Biophys Acta. 1997;1334:109-15 pubmed
    ..Furthermore, hK2 formed molecular complexes with alpha 2 -antiplasmin, alpha 1-antichymotrypsin, antithrombin III and alpha 2-macroglobulin but not with alpha 1-antitrypsin...
  5. Rogers A, Chu J, Darvishi K, Ionita Laza I, Lehmann H, Mills R, et al. Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility. Clin Exp Allergy. 2013;43:455-62 pubmed publisher
    ..The lack of linkage disequilibrium (LD) between CNVs and asthma-associated SNPs suggests that these CNVs are unlikely to represent the functional variant responsible for most known asthma associations. ..
  6. Meyer P, Krugliak L, Neely S, Levine A, Parker J, Kaplan B, et al. Acute leukemias with both myeloid and lymphoid surface markers. Cytoplasmic alpha-1-anti-chymotrypsin and alpha-1-anti-trypsin as possible indicators of early granulocytic differentiation. Am J Clin Pathol. 1986;86:461-8 pubmed
    ..leukemias (ALL) contained immunoreactive cytoplasmic alpha-1-anti-trypsin (alpha-1-AT) and alpha-1-antichymotrypsin (alpha-1-ACT)...
  7. Tang G, Xie H, Xu L, Hao Y, Lin D, Ren D. Genetic study of apolipoprotein E gene, alpha-1 antichymotrypsin gene in sporadic Parkinson disease. Am J Med Genet. 2002;114:446-9 pubmed
    ..we investigated the role of Apolipoprotein E gene polymorphism and the signal peptide polymorphism in alpha-1 antichymotrypsin (ACT) gene in idiopathic sporadic PD...
  8. Chatzipantelis P, Salla C, Apostolou G, Christodoulou L, Kakiopoulos G, Patralexis C. Endoscopic ultrasound-guided fine needle aspiration cytology diagnosis of solid pseudopapillary tumor of the pancreas: a report of 3 cases. Acta Cytol. 2010;54:701-6 pubmed
    ..synaptophysin+ (1 case), MUC1+ (focal, intensive, 1 case), EMA+ (diffuse weak, 1 case), a1-antitrypsin and a1-antichymotrypsin+ (focal intensive, 2 cases), progesterone+ (1 case), chromogranin-A- (3 cases) and NSE- (3 cases)...
  9. Zhu L, Jäämaa S, af Hällström T, Laiho M, Sankila A, Nordling S, et al. PSA forms complexes with ?1-antichymotrypsin in prostate. Prostate. 2013;73:219-26 pubmed publisher
    ..In circulation, the majority of PSA is complexed with protease inhibitors, including ?(1) -antichymotrypsin (ACT)...
  10. Lin Y, Liu Y, Chou Y, Yang S, Chien M, Wu C, et al. Correlation of chitinase 3-like 1 single nucleotide polymorphisms and haplotypes with uterine cervical cancer in Taiwanese women. PLoS ONE. 2014;9:e104038 pubmed publisher
    ..showed that the mutant homozygous genotype AA of CHI3L1 SNP rs6691378 and AA of rs10399805, and haplotypes AACC and AACT increased the risk of developing pre-cancerous lesions and invasive cancer...
  11. Belorgey D, Irving J, Ekeowa U, Freeke J, Roussel B, Miranda E, et al. Characterisation of serpin polymers in vitro and in vivo. Methods. 2011;53:255-66 pubmed publisher
    ..Others include α(1)-antitrypsin deficiency and deficiency of C1 inhibitor, antithrombin and α(1)-antichymotrypsin. The serpinopathies are characterised by delays in protein folding and the retention of ordered polymers of ..
  12. Villoutreix B, Lilja H, Pettersson K, Lovgren T, Teleman O. Structural investigation of the alpha-1-antichymotrypsin: prostate-specific antigen complex by comparative model building. Protein Sci. 1996;5:836-51 pubmed
    ..PSA interacts with at least two serine protease inhibitors (serpins): alpha-1-antichymotrypsin (ACT) and protein C inhibitor (PCI)...
  13. Hoffmann D, Textoris C, Oehme F, Klaassen T, Goppelt A, Römer A, et al. Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011;286:28889-901 pubmed publisher
    1-Antichymotrypsin (?1-ACT) is a specific inhibitor of leukocyte-derived chymotrypsin-like proteases with largely unknown functions in tissue repair...
  14. Zhou J, Cheng Y, Tang L, Martinka M, Kalia S. Up-regulation of SERPINA3 correlates with high mortality of melanoma patients and increased migration and invasion of cancer cells. Oncotarget. 2017;8:18712-18725 pubmed publisher
    ..This study confirms the prognostic potential of SERPINA3 expression in human cutaneous melanoma and reveals the pro-migration and pro-invasion functions of this protein on melanoma cells. ..
  15. Zhao K, Murray E, Murray S. HK2 Proximal Tubule Epithelial Cells Synthesize and Secrete Plasma Proteins Predominantly Through the Apical Surface. J Cell Biochem. 2017;118:924-933 pubmed publisher
    ..family chaperone, including albumin, transferrin, α1 -antitrypsin, α1 -antichymotrypsin, α2 -HS-glycoprotein, ceruloplasmin, haptoglobin, C1-inhibitor, secreted phosphoprotein-24, and ..
  16. Cheow E, Cheng W, Yap T, Dutta B, Lee C, Kleijn D, et al. Myocardial Injury Is Distinguished from Stable Angina by a Set of Candidate Plasma Biomarkers Identified Using iTRAQ/MRM-Based Approach. J Proteome Res. 2017;: pubmed publisher
  17. Schmidt K, Gardill B, Kern A, Kirchweger P, Börsch M, Muller Y. Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc Natl Acad Sci U S A. 2018;115:5744-5749 pubmed publisher
    ..of doxycycline- and doxorubicin-binding sites into the serine proteinase inhibitor (serpin) family member ?1-antichymotrypsin. Further engineering allowed exploitation of the proteinase-triggered serpin-typical S-to-R transition to ..
  18. Kalsheker N, Morley S, Morgan K. Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin. Biochem Soc Trans. 2002;30:93-8 pubmed
    ..The most abundant serpins in human plasma are alpha(1)-antitrypsin (AAT) and alpha(1)-antichymotrypsin (ACT)...
  19. Haynes B, Viale G, Galimberti V, Rotmensz N, Gibelli B, Smith I, et al. Differences in expression of proliferation-associated genes and RANKL across the menstrual cycle in estrogen receptor-positive primary breast cancer. Breast Cancer Res Treat. 2014;148:327-35 pubmed publisher
    ..This may affect the interpretation of gene expression profiles but may be exploitable as an endogenous test of endocrine responsiveness. ..
  20. Takayama T, Fujikawa K, Davie E. Characterization of the precursor of prostate-specific antigen. Activation by trypsin and by human glandular kallikrein. J Biol Chem. 1997;272:21582-8 pubmed
    ..The recombinant PSA was inhibited by alpha1-antichymotrypsin, forming an equimolar complex with a molecular mass of approximately 100 kDa...
  21. Baharvand H, Hashemi S, Kazemi Ashtiani S, Farrokhi A. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Biol. 2006;50:645-52 pubmed
  22. Mills J, Ward M, Kim W, Halliday G, Janitz M. Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome. Neuroscience. 2016;322:234-50 pubmed publisher
    ..Most of the lincRNAs specific for MSA were novel. Hence our study uncovers another level of complexity in transcriptional pathology of MSA. ..
  23. Khoonsari P, Ossipova E, Lengqvist J, Svensson C, Kosek E, Kadetoff D, et al. The human CSF pain proteome. J Proteomics. 2018;: pubmed publisher
    ..L1, complement C4-A, lysozyme C, receptor-type tyrosine-protein phosphatase zeta, apolipoprotein D, alpha-1-antichymotrypsin, granulins, calcium/calmodulin-dependent protein kinase type II subunit alpha, mast/stem cell growth factor ..
  24. Rabin M, Watson M, Kidd V, Woo S, Breg W, Ruddle F. Regional location of alpha 1-antichymotrypsin and alpha 1-antitrypsin genes on human chromosome 14. Somat Cell Mol Genet. 1986;12:209-14 pubmed
    The human protease inhibitor genes alpha 1 antitrypsin (alpha 1-PI) and alpha 1-antichymotrypsin (alpha 1-ACT) are acute-phase proteins which are induced in response to inflammation...
  25. Schechter N, Jordan L, James A, Cooperman B, Wang Z, Rubin H. Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties. J Biol Chem. 1993;268:23626-33 pubmed
    Inhibition of human chymase by alpha 1-antichymotrypsin produces 3.5 mol of degraded inhibitor for every mol of chymase inhibited, resulting in a stoichiometry of inhibition (SI) of 4.5...
  26. Hao Y, Xie H, Xu L. [Association between polymorphism of alpha 1-antichymotrypsin and apolipoprotein E gene and Parkinson's disease in Shanghai Hans]. Zhonghua Yi Xue Za Zhi. 2001;81:1172-5 pubmed
    To explore the relationship between polymorphism of alpha 1-antichymotrypsin(AACT) and apolipoprotein E(ApoE) genes and the risk of Parkinson's disease(PD) in Shanghai Hans...
  27. Wang X, DeKosky S, Ikonomovic M, Kamboh M. Distribution of plasma alpha 1-antichymotrypsin levels in Alzheimer disease patients and controls and their genetic controls. Neurobiol Aging. 2002;23:377-82 pubmed
    ..Recent studies have shown that alpha(1)-antichymotrypsin (ACT) is one of the candidate genes for AD...
  28. Chadwick J, Hauck J, Lowe J, Shaw J, Guttridge D, Gomez Sanchez C, et al. Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target. FASEB J. 2015;29:4544-54 pubmed publisher
    ..MR is a novel drug target in skeletal muscle and use of clinically safe antagonists may be beneficial for muscle diseases. ..
  29. Phelan J, Feighery R, Eldin O, Meachair S, Cannon A, Byrne R, et al. Examining the connectivity between different cellular processes in the Barrett tissue microenvironment. Cancer Lett. 2016;371:334-46 pubmed publisher
    ..tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression...
  30. Kim K, Kim C, Hong S, Jang K. A primary pure pancreatic-type acinar cell carcinoma of the stomach: a case report. Diagn Pathol. 2017;12:10 pubmed publisher
    ..The tumor cells were strongly positive for ?1-antitrypsin, chymotrypsin, and ?1-antichymotrypsin immunostaining, consistent with pancreatic exocrine differentiation...
  31. Huang W, Li Z, Zhao L, Zhao W. Simvastatin ameliorate memory deficits and inflammation in clinical and mouse model of Alzheimer's disease via modulating the expression of miR-106b. Biomed Pharmacother. 2017;92:46-57 pubmed publisher
    ..blood was collected in order to evaluate the levels of interleukin-6 (IL-6), interleukine-1 beta (IL-1?), antichymotrypsin (ACT) and human tumor necrosis factor ? (TNF-?), which were measured with the enzyme-linked immunosorbent ..
  32. Castellucci M, Theelen T, Pompili E, Fumagalli L, De Renzis G, Muhlhauser J. Immunohistochemical localization of serine-protease inhibitors in the human placenta. Cell Tissue Res. 1994;278:283-9 pubmed
    ..In the present report we investigated the immunohistochemical localization of alpha 1-antitrypsin, alpha 1-antichymotrypsin and inter-alpha-trypsin inhibitor in first trimester as well as in term human placentas...
  33. Hermans J, Stone S. Interaction of activated protein C with serpins. Biochem J. 1993;295 ( Pt 1):239-45 pubmed
    ..The kass. values for the other serpins tested (protease nexin I, protein C inhibitor, and mutants of alpha 1-antichymotrypsin and alpha 1-antitrypsin with P1 arginine residues) were at least 1000-fold higher, with P1-Arg-alpha 1-..
  34. Hook V, Purviance R, Azaryan A, Hubbard G, Krieger T. Purification and characterization of alpha 1-antichymotrypsin-like protease inhibitor that regulates prohormone thiol protease involved in enkephalin precursor processing. J Biol Chem. 1993;268:20570-7 pubmed
    Evidence is presented showing that alpha 1-antichymotrypsin (ACT) inhibits a novel prohormone thiol protease (PTP) involved in processing the enkephalin precursor...
  35. Wang Y, Liu H, Liu T, Hong C, Tsai S. Genetic association analysis of alpha-1-antichymotrypsin polymorphism in Parkinson's disease. Eur Neurol. 2001;45:254-6 pubmed
    alpha(1)-Antichymotrypsin (ACT) gene has been suggested as a susceptibility factor for Parkinson's disease (PD) and might be related to the onset of PD. We replicated these findings in a Chinese population...
  36. Cui S, Yu Z, Wu H. [Analysis of the polymorphisms of the AACT, ERAB and NACP genes in 15 patients with Alzheimer's disease]. Zhonghua Yi Xue Za Zhi. 2001;81:90-2 pubmed
    To analyze the polymorphisms of the AACT, ERAB and NACP genes in Han Chinese Alzheimer's disease (AD) patients...
  37. Leeuwerke M, Eilander M, Pruis M, Lendvai Ã, Erwich J, Scherjon S, et al. DNA Methylation and Expression Patterns of Selected Genes in First-Trimester Placental Tissue from Pregnancies with Small-for-Gestational-Age Infants at Birth. Biol Reprod. 2016;94:37 pubmed publisher
    ..This indicates that the already reported changes in term placenta are not present in the early placenta, and therefore must arise after the first trimester. ..
  38. Ji E, Hwang H, Park G, Lee J, Lee H, Choi N, et al. Analysis of fucosylation in liver-secreted N-glycoproteins from human hepatocellular carcinoma plasma using liquid chromatography with tandem mass spectrometry. Anal Bioanal Chem. 2016;408:7761-7774 pubmed
    ..37 fucosylated N-glycopeptides were newly identified from nine liver-secreted proteins, including alpha-1-antichymotrypsin, alpha-1-antitrypsin, alpha-2-HS-glycoprotein, ceruloplasmin, alpha-1-acid glycoprotein 1/2, alpha-2-..
  39. Chung C, Chang C, Hsu C, Lin K, Peng H, Huang T. Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1. Sci Rep. 2017;7:43612 pubmed publisher
    ..In this study, the anti-angiogenic efficacy of a synthesised aggretin ?-chain C-terminus (AACT, residue 106-136) was evaluated in both in vitro and in vivo angiogenesis models...
  40. Alfadda A, Benabdelkamel H, Masood A, Jammah A, Ekhzaimy A. Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis. Int J Mol Sci. 2018;19: pubmed publisher
    ..euthyroid state: complement C2, serotransferrin, complement C3, Ig ? chain C region, ?-1-antichymotrypsin, complement C4-A, haptoglobin, fibrinogen ? chain, apolipoprotein A-I, and Ig ?-1 chain C region...
  41. Kelsey G, Abeliovich D, McMahon C, Whitehouse D, Corney G, Povey S, et al. Cloning of the human alpha 1 antichymotrypsin gene and genetic analysis of the gene in relation to alpha 1 antitrypsin deficiency. J Med Genet. 1988;25:361-8 pubmed
    ..With this in mind we report the isolation of the human gene for alpha 1 antichymotrypsin (AACT) on a series of cosmid clones, with restriction mapping of about 70 kb around the gene...
  42. Harvima I, Haapanen L, Ackermann L, Naukkarinen A, Harvima R, Horsmanheimo M. Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions. Acta Derm Venereol. 1999;79:98-104 pubmed
    ..The presence of chymase inhibitor alpha 1-proteinase inhibitor (alpha 1-PI), alpha 1-antichymotrypsin (alpha 1-AC), alpha 2-macroglobulin (alpha 2-MG) and C1-esterase inhibitor (C1-Inh) immunoreactivity in mast ..
  43. Skeel A, Leonard E. alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein. J Biol Chem. 2001;276:21932-7 pubmed
    ..and transfer to a polyvinylidene membrane, N-terminal sequencing of the product identified it as alpha(1)-antichymotrypsin. The mean concentration of alpha(1)-antichymotrypsin in human plasma is 7 micrometer...
  44. Somarajan B, Kalita J, Misra U, Mittal B. A study of alpha1 antichymotrypsin gene polymorphism in Indian stroke patients. J Neurol Sci. 2010;290:57-9 pubmed publisher
    To evaluate the role of ACT gene polymorphism in primary spontaneous intracerebral hemorrhage (PSICH) and ischemic stroke (IS). 193 PSICH, 272 IS and 188 controls were included from the same geographical area...
  45. Hu X, Li Y, Li H, Fang Y, Liu M, You C. Is Alpha-1 Antichymotrypsin Gene Polymorphism a Risk Factor for Primary Intracerebral Hemorrhage? A Case-Control Study and Meta-Analysis. Med Sci Monit. 2015;21:2149-55 pubmed publisher
    Alpha-1 antichymotrypsin (ACT) signal peptide A/T polymorphism has been suggested to play a role in various brain diseases with arterial wall pathology...
  46. Jendrny C, Beck Sickinger A. Inhibition of Kallikrein-Related Peptidases 7 and 5 by Grafting Serpin Reactive-Center Loop Sequences onto Sunflower Trypsin Inhibitor-1 (SFTI-1). Chembiochem. 2016;17:719-26 pubmed publisher
    ..Peptides based on kallistatin, α1 -antichymotrypsin, and protein C inhibitor (PCI) inhibited KLK7 with Ki =0.4, 0.5, and 0.7 μm, respectively...
  47. Yonenaga Y, Kurosawa M, Mise M, Yamagishi M, Higashide S. Pancreatic-type Acinar Cell Carcinoma of the Stomach Included in Multiple Primary Carcinomas. Anticancer Res. 2016;36:2855-64 pubmed
    ..cancer cells in the first case were positive for exocrine markers, including chymotrypsin, lipase and alpha-1 antichymotrypsin (ACT), as well as neuroendocrine markers, including chromogranin A and synaptophysin...
  48. Li Q, Ding G, Li B, Guo S. Transcriptome Analysis of Genes Involved in Dendrobine Biosynthesis in Dendrobium nobile Lindl. Infected with Mycorrhizal Fungus MF23 (Mycena sp.). Sci Rep. 2017;7:316 pubmed publisher
    ..of 16 unigenes, selected randomly, proved that there were significant changes in the expression levels of AACT, MVD, PMK and TPS21 at 9 weeks after inoculation...
  49. Gibson T, Cohen P. Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases. Growth Horm IGF Res. 1999;9:241-53 pubmed
    ..Proteolysis of rh(125)I-IGFBP-3 by cathepsin G was blocked by alpha(1)-antichymotrypsin, while elastase proteolytic activity was blocked by alpha(1)-proteinase inhibitor as expected...
  50. Duranton J, Boudier C, Belorgey D, Mellet P, Bieth J. DNA strongly impairs the inhibition of cathepsin G by alpha(1)-antichymotrypsin and alpha(1)-proteinase inhibitor. J Biol Chem. 2000;275:3787-92 pubmed
    ..G (cat G) and proteinase 3 by the lung antiproteinases alpha(1)-proteinase inhibitor (alpha(1)PI), alpha(1)-antichymotrypsin (ACT), and mucus proteinase inhibitor (MPI)...
  51. Clarimon J, Bertranpetit J, Calafell F, Boada M, Tarraga L, Comas D. Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population. Psychiatr Genet. 2003;13:85-90 pubmed
    ..To overcome this limitation, nine polymorphisms in seven different candidate genes (A2M, ACT, APOE, APP, BH, HSP70-2, and IL1-A) were genotyped...
  52. Namciu S, Friedman R, Marsden M, Sarausad L, Jasoni C, Fournier R. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. Mamm Genome. 2004;15:162-78 pubmed
    ..Several differences between the MAR-Wiz predictions and the results of biochemical tests were observed. The genomic organization of the serpin gene cluster is discussed. ..
  53. Zhao Y, Liu Y, Zheng D. Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77. FEBS J. 2008;275:1025-38 pubmed publisher
    ..In the present study, we identified a novel Nur77-regulated gene, alpha1-antichymotrypsin/SerpinA3, via an approach combining computational prediction and wet-laboratory validations...
  54. Gunawardena H, O Brien J, Wrobel J, Xie L, Davies S, Li S, et al. QuantFusion: Novel Unified Methodology for Enhanced Coverage and Precision in Quantifying Global Proteomic Changes in Whole Tissues. Mol Cell Proteomics. 2016;15:740-51 pubmed publisher
    ..Label-based in-spectra quantitative peptides derived from amino acid-coded tagging (AACT, also known as SILAC) of a non-malignant mammary cell line were uniformly added to each xenograft with a constant ..
  55. Jin Y, Wang J, Ye X, Su Y, Yu G, Yang Q, et al. Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins. Br J Cancer. 2016;114:532-44 pubmed publisher
    ..A total of 53 differentially expressed proteins were identified by quantitative proteomics and four glycoproteins (AACT, AGP1, CFB and HPX) were selected for further verification by western blotting...
  56. Riby J, Mobley J, Zhang J, Bracci P, Skibola C. Serum protein profiling in diffuse large B-cell lymphoma. Proteomics Clin Appl. 2016;10:1113-1121 pubmed publisher
    ..14 (CD14), heparin sulfate proteoglycan core protein (HSPG2), extracellular matrix 1 (ECM1), and alpha-1-antichymotrypsin (ACT). These proteins were statistically significantly elevated by 68.8, 37.0, 61.6, 68.0, and 32...
  57. Gu Y, Vorburger R, Scarmeas N, Luchsinger J, Manly J, Schupf N, et al. Circulating inflammatory biomarkers in relation to brain structural measurements in a non-demented elderly population. Brain Behav Immun. 2017;65:150-160 pubmed publisher
    ..whether circulating inflammatory biomarkers c-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related to structural brain measures assessed by magnetic resonance imaging (MRI)...
  58. Tsuda M, Sei Y, Yamamura M, Yamamoto M, Shinohara Y. Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease. FEBS Lett. 1992;304:66-8 pubmed
    A new mutant alpha-1-antichymotrypsin (variant ACT) was found by direct sequencing and PCR-single strand conformation polymorphism (PCR-SSCP). This variant ACT was a point mutation of exon V of ACT, with the substitution of Met by Val...
  59. Abraham C, Shirahama T, Potter H. Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin. Neurobiol Aging. 1990;11:123-9 pubmed
    Our recent studies demonstrated that alpha 1-antichymotrypsin (ACT), a serine protease inhibitor, was associated with the beta-protein in the brain amyloid deposits of Alzheimer's disease, aged human controls and aged monkeys, suggesting ..
  60. Sepper R, Konttinen Y, Ingman T, Sorsa T. Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis. J Clin Immunol. 1995;15:27-34 pubmed
    ..proteinases, elastase, and cathepsin G, and their endogenous inhibitors, alpha 1-antitrypsin and alpha 1-antichymotrypsin, were investigated in bronchoalveolar lavage (BAL) fluid of bronchiectasis patients divided into mild, ..
  61. Janciauskiene S, Gerbord M, Lindgren S. Effects of serpins on cholesterol crystallization in model bile. J Hepatol. 1998;29:541-9 pubmed
    The serine proteinase inhibitors (serpins), alpha-1-antitrypsin (AAT) and alpha-1-antichymotrypsin (ACT), are acute phase proteins synthesized by hepatocytes and excreted to some extent into bile...
  62. Liu W, Zhu Y, Ge M, Pang Q, Yu Y. Polymorphism rs4934 of SERPINA3 and sporadic intracranial aneurysms in the Chinese population. Cerebrovasc Dis. 2010;29:68-72 pubmed publisher
    ..The rs4934 polymorphism of SERPINA3 is not associated with sporadic intracranial aneurysms among individuals of Chinese Han ethnicity. ..
  63. Bachmann M, Meissner C, Pfeilschifter J, Muhl H. Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells. Biofactors. 2017;43:283-292 pubmed publisher
    ..enhance IL-22 signaling thereby enforcing expression of the prototypic STAT3-downstrean target genes ?1-antichymotrypsin and suppressor of cytokine signaling (SOCS)-3...
  64. Casslen B. Inhibitors of trypsin, chymotrypsin and elastase in human uterine fluid. Acta Obstet Gynecol Scand. 1986;65:121-4 pubmed
    ..and elastase was present in fractions containing alpha 2-macroglobulin, alpha 1-antitrypsin, alpha 1-antichymotrypsin and antileukoprotease...
  65. Takayama T, McMullen B, Nelson P, Matsumura M, Fujikawa K. Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry. 2001;40:15341-8 pubmed
    ..These results indicate that hK4 may have a role in the physiologic processing of seminal plasma proteins such as pro-PSA, as well as in the pathogenesis of prostate cancer through its activation of pro-uPA. ..
  66. Sweet R, Kamboh M, Wisniewski S, Lopez O, Klunk W, Kaufer D, et al. Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's disease. J Geriatr Psychiatry Neurol. 2002;15:24-30 pubmed
    ..The objective of this study was to examine the effect of APOE4 and alpha1-antichymotrypsin/AA (ACT/AA) genotypes on time to psychosis onset in subjects with AD...
  67. Borgmann S, Haubitz M, Schwab S. Lack of association of alpha-1 antichymotrypsin gene polymorphism with PR3-ANCA and MPO-ANCA associated vasculitis. Autoimmunity. 2002;35:435-9 pubmed
    ..1 has been described. A1-antichymotrypsin (AACT), part of an extended serpin gene cluster, was discussed to contribute to PR3-ANCA associated ..
  68. Han Y, Yan C, Garner W. Proteolytic activation of matrix metalloproteinase-9 in skin wound healing is inhibited by alpha-1-antichymotrypsin. J Invest Dermatol. 2008;128:2334-42 pubmed publisher
    ..Then we determined that alpha-1-antichymotrypsin (alpha-ACT), an acute-phase factor abundantly present in the blister, effectively inhibited proMMP-9 ..
  69. Dou C, Zhang J, Sun Y, Zhao X, Wu Q, Ji C, et al. The association of ACT -17 A/T polymorphism with Alzheimer's disease: a meta-analysis. Curr Alzheimer Res. 2013;10:63-71 pubmed
    Association studies between Alpha-1-antichymotrypsin (ACT)-17(A > T) polymorphisms and Alzheimer's disease (AD) susceptibility have shown conflicting results...
  70. Hee S, Willis A, Tudur Smith C, Day S, Miller F, Madan J, et al. Does the low prevalence affect the sample size of interventional clinical trials of rare diseases? An analysis of data from the aggregate analysis of clinicaltrials.gov. Orphanet J Rare Dis. 2017;12:44 pubmed publisher
    ..We downloaded all clinical trials from Aggregate Analysis of ClinialTrials.gov (AACT) and identified rare disease trials by cross-referencing MeSH terms in AACT with the list from Orphadata...
  71. Pütter K, van Deenen N, Unland K, Prüfer D, Schulze Gronover C. Isoprenoid biosynthesis in dandelion latex is enhanced by the overexpression of three key enzymes involved in the mevalonate pathway. BMC Plant Biol. 2017;17:88 pubmed publisher
    ..ATP citrate lyase (ACL), which provides the acetyl-CoA utilized in the MVA pathway, and acetoacetyl-CoA thiolase (AACT), which catalyzes the first step in the pathway to produce acetoacetyl-CoA...
  72. Mikolajczyk S, Millar L, Kumar A, Saedi M. Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1. Int J Cancer. 1999;81:438-42 pubmed
    ..hK2 comparably with protein C inhibitor (PCI) and at least 20 times more rapidly than alpha1-anti-chymotrypsin (ACT)...
  73. Witt H, Kage A, Luck W, Becker M. Alpha1-antitrypsin genotypes in patients with chronic pancreatitis. Scand J Gastroenterol. 2002;37:356-9 pubmed
    ..No significant differences were found between the allele frequency in patients and the control individuals (P > 0.1). Alpha1-antitrypsin deficiency is not related to the pathogenesis of idiopathic or hereditary CP. ..
  74. Kamboh M, Minster R, Kenney M, Ozturk A, Desai P, Kammerer C, et al. Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease. Neurobiol Aging. 2006;27:1435-9 pubmed
    ..Using AAO as a covariate, a linkage signal for AD has been detected on chromosome 14q32 near the alpha1-antichymotrypsin (ACT) gene...
  75. Dardiotis E, Hadjigeorgiou G, Dardioti M, Scarmeas N, Paterakis K, Aggelakis K, et al. Alpha-1 antichymotrypsin gene signal peptide a/t polymorphism and primary intracerebral hemorrhage. Eur Neurol. 2008;59:307-14 pubmed publisher
    Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology...
  76. Porcellini E, Davis E, Chiappelli M, Ianni E, Di Stefano G, Forti P, et al. Elevated plasma levels of alpha-1-anti-chymotrypsin in age-related cognitive decline and Alzheimer's disease: a potential therapeutic target. Curr Pharm Des. 2008;14:2659-64 pubmed
    alpha-1-antichymotrypsin (ACT), is an acute phase protein and a protease inhibitor produced by the liver and brain...
  77. Fujimoto K, Ikeda S, Arai T, Tanaka N, Kumasaka T, Ishii T, et al. Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. BMC Med Genet. 2010;11:159 pubmed publisher
    ..30; p = 0.037) and the association was very prominent in smokers (OR = 2.02; 95% CI = 1.29-3.15; p = 0.002). SERPINE2 may be a risk factor for the development of emphysema and its association with emphysema may be stronger in smokers. ..
  78. Guan F, Gu J, Hu F, Zhu Y, Wang W. Association between ?1-antichymotrypsin signal peptide -15A/T polymorphism and the risk of Alzheimer's disease: a meta-analysis. Mol Biol Rep. 2012;39:6661-9 pubmed publisher
    No consensus has been recently reached at the relationship between the ?1-antichymotrypsin (ACT) signal peptide -15A/T polymorphism and Alzheimer’s disease (AD) risk...
  79. Park J, Masaki T, Mezaki Y, Yokoyama H, Nakamura M, Maehashi H, et al. Alpha-1 antichymotrypsin is involved in astrocyte injury in concert with arginine-vasopressin during the development of acute hepatic encephalopathy. PLoS ONE. 2017;12:e0189346 pubmed publisher
    ..However, many clinicians believe that there are any other factors involved in the development of HE. Therefore, the aim of this study was to identify novel HE-inducible factors, particularly those inducing astrocyte dysfunction...
  80. Lindmark B, Lilja H, Alm R, Eriksson S. The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide. Biochim Biophys Acta. 1989;997:90-5 pubmed
    ACT (alpha 1-antichymotrypsin), a serine antiproteinase with specificity against neutrophil cathepsin G, is homologous with alpha 1-antitrypsin, plasminogen activator inhibitor and angiotensinogen, all with known amino-terminal ..
  81. Chandra T, Stackhouse R, Kidd V, Robson K, Woo S. Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III. Biochemistry. 1983;22:5055-61 pubmed
    alpha 1-Antichymotrypsin mRNA was isolated by specific polysome immunoprecipitation from turpentine-treated baboon liver. The highly enriched mRNA was used for synthesis and cloning of the corresponding cDNA...
  82. Brecher A, Yang M. Acetaldehyde inhibits chymotrypsin and serum anti-chymotrypsin activity. J Investig Med. 1998;46:146-52 pubmed
    ..clearly decreases the antichymotryptic activity of serum (consisting of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin)...
  83. Janciauskiene S, Wright H. Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease. Bioessays. 1998;20:1039-46 pubmed
    ..We hypothesize that specific interactions of A beta with the inflammatory serpin, alpha 1-antichymotrypsin, abolish the serpin proteinase inhibitor activity and stimulate formation of the neurotoxic fibrillar form of ..
  84. Licastro F, Chiappelli M, Grimaldi L, Morgan K, Kalsheker N, Calabrese E, et al. A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease. Neurobiol Aging. 2005;26:449-53 pubmed
    Increased levels of alpha-1-antichymotrypsin (ACT), a protease inhibitor and an acute phase protein, have been found in the brain and peripheral blood of patients with Alzheimer's disease (AD)...
  85. Dufour E, Desilets A, Longpre J, Leduc R. Stability of mutant serpin/furin complexes: dependence on pH and regulation at the deacylation step. Protein Sci. 2005;14:303-15 pubmed
    ..design more stable, potent, and specific serpin-based inhibitors, we constructed a series of AT and alpha(1)-antichymotrypsin (ACT) mutants by modifying the P(7)-P(1) region of their RSLs...
  86. Gopalan S, Wilczynska K, Konik B, Bryan L, Kordula T. Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes. J Biol Chem. 2006;281:13126-33 pubmed
    ..1 allow a single gene encoding alpha1-antichymotrypsin (ACT) to be expressed in astrocytes and glioma cells...
  87. Licastro F, Chiapelli M, Caldarera C, Caruso C, Lio D, Corder E. Acute myocardial infarction and proinflammatory gene variants. Ann N Y Acad Sci. 2007;1119:227-42 pubmed
    ..This information may better define the pathogenesis of myocardial infarction and identify individuals who might benefit from early interventions. ..