annexin II

Summary

Gene Symbol: annexin II
Description: annexin A2
Alias: ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV, annexin A2, annexin II, annexin-2, calpactin I heavy chain, calpactin I heavy polypeptide, calpactin-1 heavy chain, chromobindin 8, epididymis secretory protein Li 270, lipocortin II, placental anticoagulant protein IV, protein I
Species: human
Products:     annexin II

Top Publications

  1. Johnsson N, Johnsson K, Weber K. A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins. FEBS Lett. 1988;236:201-4 pubmed
    Previous models of p36 based on proteolytic fragments describe the tail and core as two noninteracting domains...
  2. Matsunaga T, Inaba T, Matsui H, Okuya M, Miyajima A, Inukai T, et al. Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein. Blood. 2004;103:3185-91 pubmed
    ..Here, we report that annexin II, a surface phospholipid-binding protein and one of the proposed causes of the hemorrhagic complications of acute ..
  3. Deora A, Kreitzer G, Jacovina A, Hajjar K. An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface. J Biol Chem. 2004;279:43411-8 pubmed
    b>Annexin 2 is a profibrinolytic co-receptor for plasminogen and tissue plasminogen activator that stimulates activation of the major fibrinolysin, plasmin, at cell surfaces...
  4. Brandherm I, Disse J, Zeuschner D, Gerke V. cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2. Blood. 2013;122:1042-51 pubmed publisher
    ..Here we identify the complex consisting of the lipid-binding protein annexin A2 (AnxA2) and S100A10 as such a factor...
  5. Seidah N, Poirier S, Denis M, Parker R, Miao B, Mapelli C, et al. Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PLoS ONE. 2012;7:e41865 pubmed publisher
    ..Accordingly, the quest for PCSK9 inhibitors has major clinical implications. We have previously identified annexin A2 (AnxA2) as an endogenous binding partner and functional inhibitor of PCSK9...
  6. Kesavan K, Ratliff J, Johnson E, Dahlberg W, Asara J, Misra P, et al. Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects. J Biol Chem. 2010;285:4366-74 pubmed publisher
    ..Here, we identify annexin A2 as a novel binding partner for TM601 in multiple human tumor cell lines and human umbilical vein endothelial ..
  7. Morel E, Parton R, Gruenberg J. Annexin A2-dependent polymerization of actin mediates endosome biogenesis. Dev Cell. 2009;16:445-57 pubmed publisher
    ..Our data show that nucleation of actin patches by early endosomes is strictly dependent on annexin A2, a protein involved in early-to-late endosome transport...
  8. Zhai H, Acharya S, Gravanis I, Mehmood S, Seidman R, Shroyer K, et al. Annexin A2 promotes glioma cell invasion and tumor progression. J Neurosci. 2011;31:14346-60 pubmed publisher
    ..Tumor-associated proteases play an important role in glioma progression. Annexin A2 is overexpressed in many cancers and correlates with increased plasmin activity on the tumor cell surface, which ..
  9. Zhao P, Zhang W, Wang S, Yu X, Tang J, Huang W, et al. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. Hepatology. 2011;54:2012-24 pubmed publisher
    ..Previously, we reported that HAb18G/CD147 and annexin II are interacting proteins involved in cytoskeleton rearrangement, yet the role of their interaction is unclear...

More Information

Publications82

  1. Zhao P, Zhang W, Tang J, Ma X, Dai J, Li Y, et al. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. Cancer Sci. 2010;101:387-95 pubmed publisher
    ..Here, we found that annexin II, a 36-kDa Ca(2+)- and phospholipid-binding protein and in vivo substrate for tyrosine kinase and PKC, is a new ..
  2. Sun Y, Gao G, Cai J, Wang Y, Qu X, He L, et al. Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma. Carcinogenesis. 2013;34:595-604 pubmed publisher
    To date, the useful markers of hepatocellular carcinoma (HCC) remains incompletely developed. Here, we show that annexin A2 complement alpha-fetoprotein (AFP), a widely used liver cancer marker, in the serologically surveillance and early ..
  3. Tian W, Wijewickrama G, Kim J, Das S, Tun M, Gokhale N, et al. Mechanism of regulation of group IVA phospholipase A2 activity by Ser727 phosphorylation. J Biol Chem. 2008;283:3960-71 pubmed
    ..binding measurements by surface plasmon resonance analysis showed that a heterotetramer (A2t) of p11 and annexin A2, but not p11 or annexin A2 alone, directly binds cPLA(2)alpha via Ser(727), which keeps the enzyme from binding ..
  4. Brownstein C, Deora A, Jacovina A, Weintraub R, Gertler M, Khan K, et al. Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages. Blood. 2004;103:317-24 pubmed
    Monocytes and macrophages participate in a wide variety of host defense mechanisms. Annexin II, a fibrinolytic receptor, binds plasminogen and tissue plasminogen activator (t-PA) independently at the cell surface, thereby enhancing the ..
  5. Filipenko N, MacLeod T, Yoon C, Waisman D. Annexin A2 is a novel RNA-binding protein. J Biol Chem. 2004;279:8723-31 pubmed
    b>Annexin A2 (ANXA2) is a Ca(2+)-binding protein that is up-regulated in virally transformed cell lines and in human tumors. Here, we show that ANXA2 binds directly to both ribonucleotide homopolymers and human c-myc RNA...
  6. Hayes M, Shao D, Grieve A, Levine T, Bailly M, Moss S. Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate. Biochim Biophys Acta. 2009;1793:1086-95 pubmed publisher
    ..The calcium and anionic phospholipid-binding protein annexin A2 is necessary for macropinocytic rocketing and has been shown to bind both PI(4,5)P2 and the barbed-ends of F-..
  7. Feng J, Liu Q, Qin X, Geng Y, Zheng S, Liu T, et al. Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas. Mol Biol Rep. 2012;39:1267-74 pubmed publisher
    b>Annexin A2 and Cdc42 were identified by 2-dimensional electrophoresis (2-DE) and MALDI-TOF-MS between esophageal squamous cell carcinomas (ESCC) and corresponding normal esophagus mucosa in our previous study...
  8. Liu J, Shen J, Tanzillo Swarts A, Bhatia B, Maldonado C, Person M, et al. Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration. Oncogene. 2003;22:1475-85 pubmed
    ..The approximately 36 kDa protein was subsequently identified as annexin II by proteomic approach and confirmed by Western blotting using an annexin II-specific antibody...
  9. Huang Y, Yan C, Fu S. [The cloning and expression of apoptosis associated gene ANNEXIN A2 induced by p53 gene]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:661-4 pubmed
    ..After induction by p53 gene, the ANNEXIN A2 gene had differential expression in the cell lines; its level was down regulated in all the cells infected by ..
  10. Mai J, Finley R, Waisman D, Sloane B. Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells. J Biol Chem. 2000;275:12806-12 pubmed
    ..The annexin II light chain (p11), one of the two subunits of the annexin II tetramer, was one of the proteins identified...
  11. Ma K, Simantov R, Zhang J, Silverstein R, Hajjar K, McCrae K. High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J Biol Chem. 2000;275:15541-8 pubmed
    ..926 cells. Amino acid sequences of tryptic peptides from each of these were identical to sequences within annexin II. A role for annexin II in binding of beta(2)GPI to cells was confirmed by the observations that annexin II-..
  12. Jindal H, Chaney W, Anderson C, Davis R, Vishwanatha J. The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha. J Biol Chem. 1991;266:5169-76 pubmed
    ..Here we present data that establishes PRP 1 to be the protein-tyrosine kinase substrate, calpactin I heavy chain. Amino acid sequence analysis of six tryptic peptides of PRP 1 followed by homology search in a protein ..
  13. Patchell B, Wojcik K, Yang T, White S, Dorscheid D. Glycosylation and annexin II cell surface translocation mediate airway epithelial wound repair. Am J Physiol Lung Cell Mol Physiol. 2007;293:L354-63 pubmed
    ..b>Annexin II (AII), a calcium-dependent, membrane-associated protein, was identified as a protein associated with the CPA ..
  14. Takano S, Togawa A, Yoshitomi H, Shida T, Kimura F, Shimizu H, et al. Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy. Ann Surg Oncol. 2008;15:3157-68 pubmed publisher
    ..We identified Annexin II as an up-regulated protein in the gemcitabine-resistant pancreatic cancer cell line...
  15. Morel E, Gruenberg J. Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation. J Biol Chem. 2009;284:1604-11 pubmed publisher
    The phospholipid-binding annexin A2 (AnxA2) is known to play a role in the regulation of membrane and actin dynamics, in particular in the endocytic pathway...
  16. Gould K, Woodgett J, Isacke C, Hunter T. The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo. Mol Cell Biol. 1986;6:2738-44 pubmed
    b>p36, a major in vivo substrate of protein-tyrosine kinases, is shown to be phosphorylated at serine 25, a site very close to the major site of tyrosine phosphorylation by pp60v-src, tyrosine 23 (J. R. Glenney, Jr., and B. F. Tack, Proc...
  17. Huebner K, Cannizzaro L, Frey A, Hecht B, Hecht F, Croce C, et al. Chromosomal localization of the human genes for lipocortin I and lipocortin II. Oncogene Res. 1988;2:299-310 pubmed
    The human genes which code for Lipocortin I and Lipocortin II, proteins that inhibit phospholipase A2 (PLA2) activity, have been regionally localized in the human genome by chromosomal in situ hybridization and segregation analysis in ..
  18. Waters K, Stenoien D, Sowa M, von Neubeck C, Chrisler W, Tan R, et al. Annexin A2 modulates radiation-sensitive transcriptional programming and cell fate. Radiat Res. 2013;179:53-61 pubmed publisher
    We previously established annexin A2 as a radioresponsive protein associated with anchorage independent growth in murine epidermal cells...
  19. Ohno Y, Izumi M, Kawamura T, Nishimura T, Mukai K, Tachibana M. Annexin II represents metastatic potential in clear-cell renal cell carcinoma. Br J Cancer. 2009;101:287-94 pubmed publisher
    b>Annexin II (ANX2) is a multi-functional protein involved in cell proliferation and membrane physiology and is related to cancer progression...
  20. Rescher U, Ruhe D, Ludwig C, Zobiack N, Gerke V. Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes. J Cell Sci. 2004;117:3473-80 pubmed
    b>Annexin 2 is a Ca(2+)-regulated membrane protein and an F-actin-binding protein enriched at actin assembly sites both, on the plasma membrane and on endosomal vesicles...
  21. Benaud C, Gentil B, Assard N, Court M, Garin J, Delphin C, et al. AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. J Cell Biol. 2004;164:133-44 pubmed
    ..At the plasma membrane, AHNAK associates as a multimeric complex with actin and the annexin 2/S100A10 complex...
  22. Jia J, Li K, Wu J, Guo S. Clinical significance of annexin II expression in human non-small cell lung cancer. Tumour Biol. 2013;34:1767-71 pubmed publisher
    The aim of the present study is to explore the role of annexin II in the development and progression of human non-small cell lung cancer (NSCLC)...
  23. Ji N, Park M, Kang Y, Lee C, Kim D, Yeom Y, et al. Evaluation of annexin II as a potential serum marker for hepatocellular carcinoma using a developed sandwich ELISA method. Int J Mol Med. 2009;24:765-71 pubmed
    Annexin II (Annexin A2, ANXA2) is a 36 kDa calcium-dependent phospholipid-binding protein that is located on the surface of most eukaryotic cells...
  24. Zheng L, Foley K, Huang L, Leubner A, Mo G, Olino K, et al. Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PLoS ONE. 2011;6:e19390 pubmed publisher
    ..We identified Annexin A2 (ANXA2), a member of the Annexin family of calcium-dependent phospholipid binding proteins, as a new molecule ..
  25. Nedjadi T, Kitteringham N, Campbell F, Jenkins R, Park B, Navarro P, et al. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer. 2009;101:1145-54 pubmed publisher
    ..Our proteomic screen to identify S100A6 interacting proteins revealed annexin 11, annexin 2, tropomyosin beta and a candidate novel interactor lamin B1...
  26. Wu B, Zhang F, Yu M, Zhao P, Ji W, Zhang H, et al. Up-regulation of Anxa2 gene promotes proliferation and invasion of breast cancer MCF-7 cells. Cell Prolif. 2012;45:189-98 pubmed publisher
    ..Our findings suggest that up-regulation of Anxa2 may play an important role in modulating proliferation and invasion of breast cancer MCF-7 cells through regulation of many relevant downstream target genes. ..
  27. Mohammad H, Kurokohchi K, Yoneyama H, Tokuda M, Morishita A, Jian G, et al. Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. Int J Oncol. 2008;33:1157-63 pubmed
    ..Among these, Annexin A2 (ANXA2) has been revealed as a multi-functional protein in vitro...
  28. Liu Y, Wang Z, Jiang M, Dai L, Zhang W, Wu D, et al. The expression of annexin II and its role in the fibrinolytic activity in acute promyelocytic leukemia. Leuk Res. 2011;35:879-84 pubmed publisher
    ..b>Annexin II (Ann II) is a co-receptor for plasminogen and tissue plasminogen activator (tPA)...
  29. Rescher U, Ludwig C, Konietzko V, Kharitonenkov A, Gerke V. Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion. J Cell Sci. 2008;121:2177-85 pubmed publisher
    ..In a cellular model system for tyrosine phosphorylation-based growth factor signaling, we observed that annexin A2 is tyrosine-phosphorylated upon insulin receptor activation...
  30. Pena Alonso E, Rodrigo J, Parra I, Pedrero J, Meana M, Nieto C, et al. Annexin A2 localizes to the basal epithelial layer and is down-regulated in dysplasia and head and neck squamous cell carcinoma. Cancer Lett. 2008;263:89-98 pubmed publisher
    b>Annexin A2 is a highly expressed gene with important roles in cell membrane physiology and is frequently dysregulated in cancer...
  31. Sharma M, Ownbey R, Sharma M. Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation. Exp Mol Pathol. 2010;88:278-86 pubmed publisher
    b>Annexin II, an abundant phospholipids binding cell surface protein, binds tPA and functions as a regulator of fibrinolysis. Annexin II also mediates angiogenesis and enhances tumor growth and metastasis...
  32. Burger A, Berendes R, Liemann S, Benz J, Hofmann A, Göttig P, et al. The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein. J Mol Biol. 1996;257:839-47 pubmed
    b>Annexin II binds in a calcium-dependent manner to acidic phospholipids and is a substrate of some protein kinases. An N-terminally shortened form of human annexin II was crystallized and its molecular structure determined...
  33. Gokhale N, Abraham A, Digman M, Gratton E, Cho W. Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. J Biol Chem. 2005;280:42831-40 pubmed
    Annexin A2 is a phospholipid-binding protein that forms a heterotetramer (annexin II-p11 heterotetramer; A2t) with p11 (S100A10)...
  34. Nazmi A, Ozorowski G, Pejic M, Whitelegge J, Gerke V, Luecke H. N-terminal acetylation of annexin A2 is required for S100A10 binding. Biol Chem. 2012;393:1141-50 pubmed publisher
    b>Annexin A2 (AnxA2), a Ca2+-regulated phospholipid binding protein involved in membrane-cytoskeleton contacts and membrane transport, exists in two physical states, as a monomer or in a heterotetrameric complex mediated by S100A10...
  35. Emans N, Gorvel J, Walter C, Gerke V, Kellner R, Griffiths G, et al. Annexin II is a major component of fusogenic endosomal vesicles. J Cell Biol. 1993;120:1357-69 pubmed
    ..Partial sequencing and Western blotting indicated that one of the latter components is annexin II, a protein known to mediate membrane-membrane interactions...
  36. Dziduszko A, Ozbun M. Annexin A2 and S100A10 regulate human papillomavirus type 16 entry and intracellular trafficking in human keratinocytes. J Virol. 2013;87:7502-15 pubmed publisher
    ..Src protein kinase activation that results in phosphorylation and extracellular translocation of annexin A2 (AnxA2)...
  37. Siao C, Tsirka S. Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II. J Neurosci. 2002;22:3352-8 pubmed
    ..We also show that the finger domain of tPA is necessary to trigger the activation and identify annexin II as its probable binding partner-receptor...
  38. van de Graaf S, Hoenderop J, Gkika D, Lamers D, Prenen J, Rescher U, et al. Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J. 2003;22:1478-87 pubmed
    ..This S100 protein forms a heterotetrameric complex with annexin 2 and associates specifically with the conserved sequence VATTV located in the C-terminal tail of TRPV5 and TRPV6...
  39. Zobiack N, Rescher U, Ludwig C, Zeuschner D, Gerke V. The annexin 2/S100A10 complex controls the distribution of transferrin receptor-containing recycling endosomes. Mol Biol Cell. 2003;14:4896-908 pubmed
    The Ca2+- and lipid-binding protein annexin 2, which resides in a tight heterotetrameric complex with the S100 protein S100A10 (p11), has been implicated in the structural organization and dynamics of endosomal membranes...
  40. Lennon N, Kho A, Bacskai B, Perlmutter S, Hyman B, Brown R. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003;278:50466-73 pubmed
    ..We propose a model of muscle membrane healing mediated by dysferlin that is relevant to both normal and dystrophic muscle and defines the annexins as potential muscular dystrophy genes. ..
  41. Zhang F, Zhang L, Zhang B, Wei X, Yang Y, Qi R, et al. Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. J Proteome Res. 2009;8:5041-7 pubmed publisher
    ..b>Annexin a2 (Anxa2) was identified as highly expressed in MCF-7/ADR cells, but not in MCF-7 cells...
  42. Guzman Aranguez A, Olmo N, Turnay J, Lecona E, Pérez Ramos P, Lopez de Silanes I, et al. Differentiation of human colon adenocarcinoma cells alters the expression and intracellular localization of annexins A1, A2, and A5. J Cell Biochem. 2005;94:178-93 pubmed
    ..Thus, we have analyzed changes in annexin A1 (AnxA1), annexin A2 (AnxA2), and annexin A5 (AnxA5) levels and localization in human colon adenocarcinoma cells differentiated by ..
  43. Ryzhova E, Vos R, Albright A, Harrist A, Harvey T, Gonzalez Scarano F. Annexin 2: a novel human immunodeficiency virus type 1 Gag binding protein involved in replication in monocyte-derived macrophages. J Virol. 2006;80:2694-704 pubmed
    ..In this study we defined annexin 2 (Anx2) as a novel HIV Gag binding partner in macrophages...
  44. Wahl S, Greenwell Wild T, Vazquez N. HIV accomplices and adversaries in macrophage infection. J Leukoc Biol. 2006;80:973-83 pubmed
    ..For example, in addition to CD4 and CCR5, membrane annexin II facilitates early steps in infection of macrophages, but not in T cells...
  45. Zhang Y, Zhou Z, Bugge T, Wahl L. Urokinase-type plasminogen activator stimulation of monocyte matrix metalloproteinase-1 production is mediated by plasmin-dependent signaling through annexin A2 and inhibited by inactive plasmin. J Immunol. 2007;179:3297-304 pubmed
    ..plasmin generated by the action of uPA or exogenous plasmin increased MMP-1 synthesis by signaling through annexin A2, as demonstrated by inhibition of MMP-1 production with Abs against annexin A2 and S100A10, a dimeric protein ..
  46. Chertova E, Chertov O, Coren L, Roser J, Trubey C, Bess J, et al. Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages. J Virol. 2006;80:9039-52 pubmed
    ..MDM-derived HIV contained 26 of 37 proteins previously found in exosomes, consistent with the idea that HIV uses the late endosome/multivesicular body pathway during virion budding from macrophages. ..
  47. Shiozawa Y, Havens A, Jung Y, Ziegler A, Pedersen E, Wang J, et al. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. J Cell Biochem. 2008;105:370-80 pubmed publisher
    ..Our recent work demonstrated that annexin II expressed by osteoblasts and endothelial cells plays a critical role in niche selection...
  48. Sharma M, Koltowski L, Ownbey R, Tuszynski G, Sharma M. Angiogenesis-associated protein annexin II in breast cancer: selective expression in invasive breast cancer and contribution to tumor invasion and progression. Exp Mol Pathol. 2006;81:146-56 pubmed
    ..The mechanism of this effect is poorly understood. Here we report that annexin II, an endothelial co-receptor for tPA (tissue-type plasminogen activator) and plasminogen, was undetectable in ..
  49. Aranda Orgilles B, Trockenbacher A, Winter J, Aigner J, Köhler A, Jastrzebska E, et al. The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex. Hum Genet. 2008;123:163-76 pubmed publisher
    ..1alpha (EF-1alpha) and several other proteins involved in mRNA transport and translation, including RACK1, Annexin A2, Nucleophosmin and proteins of the small ribosomal subunits...
  50. Zhang H, Yao D, Yao M, Huang H, Wu W, Yan M, et al. Expression characteristics and diagnostic value of annexin A2 in hepatocellular carcinoma. World J Gastroenterol. 2012;18:5897-904 pubmed publisher
    To investigate the characteristics and diagnostic value of annexin A2 (ANXA2) expression in cancerous tissues and sera of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)...
  51. Rety S, Sopkova J, Renouard M, Osterloh D, Gerke V, Tabaries S, et al. The crystal structure of a complex of p11 with the annexin II N-terminal peptide. Nat Struct Biol. 1999;6:89-95 pubmed
    The aggregation and membrane fusion properties of annexin II are modulated by the association with a regulatory light chain called p11...
  52. Raynor C, Wright J, Waisman D, Pryzdial E. Annexin II enhances cytomegalovirus binding and fusion to phospholipid membranes. Biochemistry. 1999;38:5089-95 pubmed
    A number of studies have suggested that the anionic phospholipid (anPL)-binding protein annexin II may play a role in cytomegalovirus (CMV) infection...
  53. Martin M, Leffler J, Blom A. Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells. J Biol Chem. 2012;287:33733-44 pubmed
    ..We revealed that the two phospholipid-binding proteins annexin A2 and A5 are, beside DNA, significant C1q ligands...
  54. Spijkers Hagelstein J, Mimoso Pinhanços S, Schneider P, Pieters R, Stam R. Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia. Leukemia. 2013;27:1063-71 pubmed publisher
    ..the underlying factor of this association was the presence of Src kinase-induced phosphorylation (activation) of annexin A2, a process requiring the adapter protein p11 (encoded by human S100A10)...
  55. Seckinger A, Meissner T, Moreaux J, Depeweg D, Hillengass J, Hose K, et al. Clinical and prognostic role of annexin A2 in multiple myeloma. Blood. 2012;120:1087-94 pubmed publisher
    b>Annexin A2 (ANXA2) promotes myeloma cell growth, reduces apoptosis in myeloma cell lines, and increases osteoclast formation...
  56. Kwon M, MacLeod T, Zhang Y, Waisman D. S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors. Front Biosci. 2005;10:300-25 pubmed
    ..Typically, S100A10 is found in most cells bound to its annexin A2 ligand as the heterotetrameric (S100A10)2(annexin A2)2 complex, AIIt...
  57. Deng S, Jing B, Xing T, Hou L, Yang Z. Overexpression of annexin A2 is associated with abnormal ubiquitination in breast cancer. Genomics Proteomics Bioinformatics. 2012;10:153-7 pubmed publisher
    Abnormal expression of annexin A2 contributes to metastasis and infiltration of cancer cells...
  58. Wang C, Chen C, Tseng Y, Fang Y, Lin Y, Su W, et al. Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms. J Biol Chem. 2012;287:32512-24 pubmed
    b>Annexin A2 (ANXA2) overexpression is required for cancer cell proliferation; however, the molecular mechanisms underlying ANXA2-mediated regulation of the cell cycle are still unknown...
  59. Becker T, Weber K, Johnsson N. Protein-protein recognition via short amphiphilic helices; a mutational analysis of the binding site of annexin II for p11. EMBO J. 1990;9:4207-13 pubmed
    b>Annexin II (p36) interacts with its ligand p11 via the short stretch of 12 amino acids (Ac-S-T-V-H-E-I-L-C-K-L-S-L) situated at the N-terminus...
  60. Mayer G, Poirier S, Seidah N. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J Biol Chem. 2008;283:31791-801 pubmed publisher
    ..and mass spectrometry analysis, we demonstrated that PCSK9 binds to a approximately 33-kDa protein identified as annexin A2 (AnxA2) but not to the closely related annexin A1...
  61. He K, Deora A, Xiong H, Ling Q, Weksler B, Niesvizky R, et al. Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11. J Biol Chem. 2008;283:19192-200 pubmed publisher
    The annexin A2 (A2) heterotetramer, consisting of two copies of A2 and two copies of S100A10/p11, promotes fibrinolytic activity on the surface of vascular endothelial cells by assembling plasminogen and tissue plasminogen activator (tPA) ..
  62. Morel E, Gruenberg J. The p11/S100A10 light chain of annexin A2 is dispensable for annexin A2 association to endosomes and functions in endosomal transport. PLoS ONE. 2007;2:e1118 pubmed
    b>Annexin A2 is a peripheral membrane protein that belongs to the annexin family of Ca(2+) and phospholipid-binding proteins...
  63. Gillette J, Chan D, Nielsen Preiss S. Annexin 2 expression is reduced in human osteosarcoma metastases. J Cell Biochem. 2004;92:820-32 pubmed
    ..These data suggest that annexin2 may downregulate osteosarcoma aggressiveness by inducing a more differentiated state in osteoblastic cells. ..
  64. Banerjee A, Liu J, Yuan Y, Gopalakrishnan V, Johansson S, Dinda A, et al. Expression of biomarkers modulating prostate cancer angiogenesis: differential expression of annexin II in prostate carcinomas from India and USA. Mol Cancer. 2003;2:34 pubmed
    ..The mechanistic and regulatory role of Anx-II in PCa progression warrants further investigation. ..
  65. Kwon M, Caplan J, Filipenko N, Choi K, Fitzpatrick S, Zhang L, et al. Identification of annexin II heterotetramer as a plasmin reductase. J Biol Chem. 2002;277:10903-11 pubmed
    b>Annexin II heterotetramer (AIIt) is a Ca(2+)- and phospholipid-binding protein that consists of two copies of a p36 and p11 subunit. AIIt regulates the production and autoproteolysis of plasmin at the cell surface...
  66. Sharma M, Blackman M, Sharma M. Antibody-directed neutralization of annexin II (ANX II) inhibits neoangiogenesis and human breast tumor growth in a xenograft model. Exp Mol Pathol. 2012;92:175-84 pubmed publisher
    ..We previously identified annexin II (ANX II), a fibrinolytic receptor, in human breast tumor tissue samples and observed a strong positive ..
  67. Bao H, Jiang M, Zhu M, Sheng F, Ruan J, Ruan C. Overexpression of Annexin II affects the proliferation, apoptosis, invasion and production of proangiogenic factors in multiple myeloma. Int J Hematol. 2009;90:177-185 pubmed publisher
    The abnormal expression of Annexin II (AnxA2, A2) has been associated with the development of tumors; however, its expression and function in multiple myeloma (MM) is less known...
  68. Inokuchi J, Narula N, Yee D, Skarecky D, Lau A, Ornstein D, et al. Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells. Int J Cancer. 2009;124:68-74 pubmed publisher
    Several groups, including ours, have reported that annexin A2 (ANXA2) expression is reduced in most prostate cancer (CaP)...
  69. Semov A, Moreno M, Onichtchenko A, Abulrob A, Ball M, Ekiel I, et al. Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation. J Biol Chem. 2005;280:20833-41 pubmed
    ..Here we report that extracellular S100A4 interacts with annexin II, an endothelial plasminogen co-receptor...
  70. Wang C, Lin Y, Su W, Chen C, Lin C. Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis. Mol Biol Cell. 2009;20:4153-61 pubmed publisher
    b>Annexin A2 is involved in multiple cellular processes, including cell survival, growth, division, and differentiation. A lack of annexin A2 makes cells more sensitive to apoptotic stimuli...
  71. Hastie C, Masters J, Moss S, Naaby Hansen S. Interferon-gamma reduces cell surface expression of annexin 2 and suppresses the invasive capacity of prostate cancer cells. J Biol Chem. 2008;283:12595-603 pubmed publisher
    ..In contrast, the expression of annexin 2 and its binding partner p11 decreased by 4-fold after 24 h of exposure, with the remaining anx2(t) complexes ..
  72. Fan X, Krahling S, Smith D, Williamson P, Schlegel R. Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes. Mol Biol Cell. 2004;15:2863-72 pubmed
    ..Annexin bridging is vectorial, because annexin is bound to PS molecules on targets but not on macrophages, suggesting annexins serve as both ligand and receptor in promoting phagocytosis. ..
  73. Chung C, Erickson H. Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. J Cell Biol. 1994;126:539-48 pubmed
    ..Protein sequencing indicated that this 35-kD receptor was annexin II. Annexin II is well characterized as a cytoplasmic protein, so it was surprising to find it as a presumably ..