Annexin I

Summary

Gene Symbol: Annexin I
Description: annexin A1
Alias: ANX1, LPC1, annexin A1, annexin I (lipocortin I), annexin-1, calpactin II, calpactin-2, chromobindin-9, phospholipase A2 inhibitory protein
Species: human
Products:     Annexin I

Top Publications

  1. Walther A, Riehemann K, Gerke V. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5:831-40 pubmed
    The glucocorticoid-regulated protein annexin I (lipocortin I) has been shown to mediate antiinflammatory activities of glucocorticoids, but the molecular basis of its action has remained elusive...
  2. Wang D, Zhang H, Fang Z, Yu G. Annexin-1 downregulation is associated with clinical outcome in Chinese patients with hilar cholangiocarcinoma. Eur Surg Res. 2010;45:151-7 pubmed publisher
    b>Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and has been implicated in regulating inflammatory responses, cell proliferation and apoptosis. The evidence of its importance in carcinogenesis increased rapidly...
  3. Guo C, Liu S, Sun M. Potential role of Anxa1 in cancer. Future Oncol. 2013;9:1773-93 pubmed publisher
    ..Anxa1 has the potential to be used in the future as a biomarker for the diagnosis, treatment and prognosis of certain tumors. ..
  4. Yang L, Yang Z, Tan X, Miao X. [Expression of annexin A1 (ANXA1) and A2 (ANXA2) and its significance in benign and malignant lesions of gallbladder]. Zhonghua Zhong Liu Za Zhi. 2010;32:595-9 pubmed
    ..The expression levels of ANXA1 and/or ANXA2 may be important biological markers in the carcinogenesis, progression and biological behaviors of gallbladder adenocarcinoma. ..
  5. Nomura H, Uzawa K, Yamano Y, Fushimi K, Nakashima D, Kouzu Y, et al. Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation. J Cancer Res Clin Oncol. 2009;135:943-9 pubmed publisher
    ..012). Our findings suggest that loss of ANXA1 is frequent and early event during oral carcinogenesis and that ANXA1 could contribute to maintaining epithelial differentiation in OSCC. ..
  6. Maschler S, Gebeshuber C, Wiedemann E, Alacakaptan M, Schreiber M, Custic I, et al. Annexin A1 attenuates EMT and metastatic potential in breast cancer. EMBO Mol Med. 2010;2:401-14 pubmed publisher
    ..Here we identify Annexin A1 (AnxA1), a protein with important functions in intracellular vesicle trafficking, as an efficient suppressor of ..
  7. Biaoxue R, Xiling J, Shuanying Y, Wei Z, Xiguang C, Jinsui W, et al. Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients. J Exp Clin Cancer Res. 2012;31:70 pubmed
    Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood...
  8. Petrella A, Festa M, Ercolino S, Zerilli M, Stassi G, Solito E, et al. Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation. Cancer Biol Ther. 2006;5:643-7 pubmed
    ..Thus ANXA1 expression may correlate with the tumorigenesis suggesting that the protein may represent an effective differentiation marker in thyroid cancer. ..
  9. Scannell M, Flanagan M, deStefani A, Wynne K, Cagney G, Godson C, et al. Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages. J Immunol. 2007;178:4595-605 pubmed
    ..These data highlight the role of annexin-1 and peptide derivatives in promoting the resolution of inflammation and expand on the therapeutic anti-inflammatory potential of annexin-1. ..

More Information

Publications73

  1. McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies G, et al. Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. J Immunol. 2010;185:6317-28 pubmed publisher
    ..The protein annexin A1 (ANXA1) is key to the phagocytosis of apoptotic leukocytes during peripheral inflammatory resolution, but the ..
  2. Wang L, Bi J, Yao C, Xu X, Li X, Wang S, et al. Annexin A1 expression and its prognostic significance in human breast cancer. Neoplasma. 2010;57:253-9 pubmed
    b>Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and is considered to play an important role in tumorigenesis...
  3. Wang L, Yang Y, Liu Y, Song H, Zhang L, Li P. Decreased expression of annexin A1 during the progression of cervical neoplasia. J Int Med Res. 2008;36:665-72 pubmed
    The aim of this study was to evaluate whether the expression of annexin A1 (ANXA1) is associated with the progression of cervical neoplasia...
  4. Alves V, Nonogaki S, Cury P, Wunsch Filho V, de Carvalho M, Michaluart Junior P, et al. Annexin A1 subcellular expression in laryngeal squamous cell carcinoma. Histopathology. 2008;53:715-27 pubmed publisher
    b>Annexin A1 (ANXA1) is a soluble cytoplasmic protein, moving to membranes when calcium levels are elevated...
  5. Perretti M, Solito E. Annexin 1 and neutrophil apoptosis. Biochem Soc Trans. 2004;32:507-10 pubmed
    ANXA1 (annexin 1), a member of the 'annexin' family of calcium- and phospholipid-binding proteins, was originally identified as an endogenous mediator of the anti-inflammatory actions of glucocorticoids...
  6. Fan X, Krahling S, Smith D, Williamson P, Schlegel R. Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes. Mol Biol Cell. 2004;15:2863-72 pubmed
    ..Jurkat T lymphocytes and human peripheral T lymphocytes, but not apoptotic thymocytes, were stained by anti-annexin I but not II...
  7. Shimoji T, Murakami K, Sugiyama Y, Matsuda M, Inubushi S, Nasu J, et al. Identification of annexin A1 as a novel substrate for E6AP-mediated ubiquitylation. J Cell Biochem. 2009;106:1123-35 pubmed publisher
    ..Here we identified annexin A1, a member of the annexin superfamily, as an E6AP-binding protein...
  8. Protzel C, Richter M, Poetsch M, Kakies C, Zimmermann U, Woenckhaus C, et al. The role of annexins I, II and IV in tumor development, progression and metastasis of human penile squamous cell carcinomas. World J Urol. 2011;29:393-8 pubmed publisher
    ..Since Annexins are potential prognostic markers in a variety of tumors, we immunohistochemically examined the expression of Annexins I, II and IV (ANX AI, ANX AII and ANX AIV) in PSCC...
  9. de Graauw M, van Miltenburg M, Schmidt M, Pont C, Lalai R, Kartopawiro J, et al. Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. Proc Natl Acad Sci U S A. 2010;107:6340-5 pubmed publisher
    b>Annexin A1 (AnxA1) is a candidate regulator of the epithelial- to mesenchymal (EMT)-like phenotypic switch, a pivotal event in breast cancer progression...
  10. Côté M, Lavoie J, Houle F, Poirier A, Rousseau S, Huot J. Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1. J Biol Chem. 2010;285:8013-21 pubmed publisher
    In this study, we obtained evidence indicating that annexin 1 is a new target of the p38/MAPKAP kinase-2 pathway and that it regulates endothelial cell migration in response to vascular endothelial growth factor (VEGF)...
  11. Cao Y, Li Y, Edelweiss M, Arun B, Rosen D, Resetkova E, et al. Loss of annexin A1 expression in breast cancer progression. Appl Immunohistochem Mol Morphol. 2008;16:530-4 pubmed publisher
    b>Annexin A1 (ANXA1) is a potential marker of development of breast cancer. However, previous studies of ANXA1 expression in primary breast carcinoma and lymph node metastasis have yielded conflicting results...
  12. Cheng T, Wu M, Lin J, Lin M, Shun C, Huang H, et al. Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway. Cancer. 2012;118:5757-67 pubmed publisher
    b>Annexin A1 (AnxA1) has been well-known as a glucocorticoid-regulated anti-inflammatory protein, and it is implicated in tumorigenesis in a tumor type-specific pattern...
  13. Schittenhelm J, Trautmann K, Tabatabai G, Hermann C, Meyermann R, Beschorner R. Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival. Mod Pathol. 2009;22:1600-11 pubmed publisher
    ..Thus, annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof. ..
  14. Wang K, Wu T, Resetkova E, Wang H, Correa A, Hofstetter W, et al. Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. Clin Cancer Res. 2006;12:4598-604 pubmed
    b>Annexin A1 (ANXA1) is a calcium-binding protein involved in arachidonic acid metabolism and epidermal growth factor receptor tyrosine kinase pathway...
  15. Pupjalis D, Goetsch J, Kottas D, Gerke V, Rescher U. Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling. EMBO Mol Med. 2011;3:102-14 pubmed publisher
    ..We report here that this is in part mediated by the release of the anti-inflammatory mediator annexin A1 from apoptotic cells and the functional activation of annexin A1 receptors of the formyl peptide receptor (FPR) ..
  16. Blume K, Soeroes S, Waibel M, Keppeler H, Wesselborg S, Herrmann M, et al. Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis. J Immunol. 2009;183:8138-47 pubmed publisher
    ..In the present study, we investigated the role of annexin A1, an intracellular protein that has been implicated in the efficient removal of apoptotic cells...
  17. Lim L, Pervaiz S. Annexin 1: the new face of an old molecule. FASEB J. 2007;21:968-75 pubmed
    ..late 1970s and subsequently referred to as macrocortin, renocortin, lipomodulin, lipocortin-1, and more recently Annexin 1, this 37 kDa calcium and phospholipid binding protein is a strong inhibitor of glucocorticoid-induced eicosanoid ..
  18. McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J, et al. Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. FASEB J. 2009;23:4000-10 pubmed publisher
    The glucocorticoid-regulated protein annexin A1 is a potent inhibitor of hormone exocytosis in the neuroendocrine system, acting in a paracrine/juxtacrine manner...
  19. Hu N, Flaig M, Su H, Shou J, Roth M, Li W, et al. Comprehensive characterization of annexin I alterations in esophageal squamous cell carcinoma. Clin Cancer Res. 2004;10:6013-22 pubmed
    The purpose is to characterize alterations of the annexin I gene, its mRNA, and protein expression in esophageal squamous cell carcinoma...
  20. Han G, Tian Y, Duan B, Sheng H, Gao H, Huang J. Association of nuclear annexin A1 with prognosis of patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7:751-9 pubmed
    ..The aim of this study was to evaluate the relationship between the expressions of Annexin A1 (ANXA1), three prime repair exonuclease 1 (TREX1) and apurinic/apyrimidinic endonuclease-1 (APE1) and clinical ..
  21. Liu Y, Zhang P, Li M, Li Q, Chen Z. Identification of annexin A1 as a proinvasive and prognostic factor for lung adenocarcinoma. Clin Exp Metastasis. 2011;28:413-25 pubmed publisher
    ..In this study, annexin A1 was identified to be significantly up-regulated in LNM AdC compared with non-LNM AdC...
  22. Blume K, Soeroes S, Keppeler H, Stevanovic S, Kretschmer D, Rautenberg M, et al. Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal. J Immunol. 2012;188:135-45 pubmed publisher
    b>Annexin A1 is an intracellular calcium/phospholipid-binding protein that is involved in membrane organization and the regulation of the immune system...
  23. Arur S, Uche U, Rezaul K, Fong M, Scranton V, Cowan A, et al. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell. 2003;4:587-98 pubmed
    ..Using a differential proteomics technology, we identify that annexin I is a caspase-dependent engulfment ligand; it is recruited from the cytosol and exported to the outer plasma ..
  24. Shen D, Nooraie F, Elshimali Y, Lonsberry V, He J, Bose S, et al. Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis. Hum Pathol. 2006;37:1583-91 pubmed
    b>Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and a known mediator of glucocorticoid-regulated inflammatory responses...
  25. D Acquisto F, Merghani A, Lecona E, Rosignoli G, Raza K, Buckley C, et al. Annexin-1 modulates T-cell activation and differentiation. Blood. 2007;109:1095-102 pubmed
  26. Gavins F, Dalli J, Flower R, Granger D, Perretti M. Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. FASEB J. 2007;21:1751-8 pubmed
    The purpose of this study was to investigate the role of the homeostatic antiinflammatory axis centered on annexin 1 (AnxA1) in cerebral microvascular dysfunction and tissue injury associated with middle cerebral artery (MCA) occlusion ..
  27. Vong L, D Acquisto F, Pederzoli Ribeil M, Lavagno L, Flower R, Witko Sarsat V, et al. Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3. J Biol Chem. 2007;282:29998-30004 pubmed
    b>Annexin 1 is an anti-inflammatory protein that plays a key role in innate immunity by modulating the activation of several types of cells, including neutrophils...
  28. Sakaguchi M, Murata H, Sonegawa H, Sakaguchi Y, Futami J, Kitazoe M, et al. Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells. J Biol Chem. 2007;282:35679-86 pubmed
    Regulation of cell growth and apoptosis is one of the pleiotropic functions of annexin A1 (ANXA1)...
  29. Kang H, Ko J, Jang S. The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells. Biochem Biophys Res Commun. 2012;423:188-94 pubmed publisher
    ..In the current study, we examined the potential role of annexin A1 (ANXA1) in regulating migration and invasion in breast cancer cell lines...
  30. Rodrigo J, García Pedrero J, Llorente J, Fresno M, Allonca E, Suarez C, et al. Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. Hum Pathol. 2011;42:88-94 pubmed publisher
    ..In this study the expression of annexin A1 and annexin A2 was studied by immunohistochemistry in intestinal-type sinonasal adenocarcinoma using a study set ..
  31. Patton K, Chen H, Joseph L, Yang X. Decreased annexin I expression in prostatic adenocarcinoma and in high-grade prostatic intraepithelial neoplasia. Histopathology. 2005;47:597-601 pubmed
    To analyse annexin I expression in prostatic carcinoma. Annexin I belongs to a family of structurally related calcium and phospholipid-binding proteins implicated in signal transduction, DNA replication, cell proliferation and apoptosis...
  32. Su N, Xu X, Chen H, Gao W, Ruan C, Wang Q, et al. Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer. Tohoku J Exp Med. 2010;222:243-50 pubmed
    The activation of K-ras gene and expression of annexin A1 play an important role in colorectal tumorigenesis...
  33. Bist P, Leow S, Phua Q, Shu S, Zhuang Q, Loh W, et al. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-?B: implication in breast cancer metastasis. Oncogene. 2011;30:3174-85 pubmed publisher
    ..Our data reveal that ANXA1 can constitutively activate NF-?B in breast cancer cells through the interaction with the IKK complex, and suggests that modulating ANXA1 levels has therapeutic potential to suppress breast cancer metastasis. ..
  34. Jorge Y, Mataruco M, Araujo L, Rossi A, de Oliveira J, Valsechi M, et al. Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer. Mediators Inflamm. 2013;2013:152860 pubmed publisher
    ..These results have provided evidence that galectin-1 and mainly annexin-A1 are overexpressed in both gastritis and gastric cancer, suggesting a strong association of these proteins with chronic gastric inflammation and carcinogenesis. ..
  35. Li C, Shen K, Huang L, Huang H, Wang Y, Wu T. Annexin-I overexpression is associated with tumour progression and independently predicts inferior disease-specific and metastasis-free survival in urinary bladder urothelial carcinoma. Pathology. 2010;42:43-9 pubmed publisher
    ..The above results reinforced the comparative proteomics results and confirmed the prognostic role of ANXA1 in UBUC. ..
  36. Leoni G, Alam A, Neumann P, Lambeth J, Cheng G, McCoy J, et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 2013;123:443-54 pubmed publisher
    ..We describe a novel intestinal epithelial FPR signaling pathway that is activated by an endogenous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS by an epithelial NADPH oxidase, NOX1...
  37. Wang Y, Serfass L, Roy M, Wong J, Bonneau A, Georges E. Annexin-I expression modulates drug resistance in tumor cells. Biochem Biophys Res Commun. 2004;314:565-70 pubmed
    ..Analysis of the P-40 amino acid sequence showed it is identical to the human annexin I (Anx-I) protein...
  38. Ang E, Nguyen H, Sim H, Putti T, Lim L. Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells. Mol Cancer Res. 2009;7:266-74 pubmed publisher
    ..Finally, we show that ANXA1-deficient mice exhibit faster carcinogen-induced tumor growth. Our data suggest that ANXA1 may act as a tumor suppressor gene and modulate the proliferative functions of estrogens. ..
  39. Vong L, Ferraz J, Dufton N, Panaccione R, Beck P, Sherman P, et al. Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis. PLoS ONE. 2012;7:e39244 pubmed publisher
    ..Our results demonstrate a specific up-regulation of this pro-resolution circuit in individuals in remission from UC, and suggest a significant role for LXA(4) and AnxA1 in promoting mucosal homeostasis. ..
  40. Cristante E, McArthur S, Mauro C, Maggioli E, Romero I, Wylezinska Arridge M, et al. Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc Natl Acad Sci U S A. 2013;110:832-41 pubmed publisher
    ..Here we show that the glucocorticoid anti-inflammatory messenger annexin A1 (ANXA1) is expressed in brain microvascular endothelial cells, where it regulates BBB integrity...
  41. Luthra R, Singh R, Luthra M, Li Y, Hannah C, Romans A, et al. MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers. Oncogene. 2008;27:6667-78 pubmed publisher
    Suppression of annexin A1 (ANXA1), a mediator of apoptosis and inhibitor of cell proliferation, is well documented in various cancers but the underlying mechanism remains unknown...
  42. Brancaleone V, Dalli J, Bena S, Flower R, Cirino G, Perretti M. Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol. 2011;186:4905-14 pubmed publisher
    ..In this article, we focused on lipoxin A(4) (LXA(4)) and annexin A1 (AnxA1) because these two very different mediators converge on a single receptor, formyl peptide receptor type 2 ..
  43. Cicek M, Samant R, Kinter M, Welch D, Casey G. Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells. Clin Exp Metastasis. 2004;21:149-57 pubmed
    ..Differential expression was confirmed for five proteins, including annexin I and alpha B-crystallin, by Northern blot analysis and immunostaining...
  44. Dorovkov M, Ryazanov A. Phosphorylation of annexin I by TRPM7 channel-kinase. J Biol Chem. 2004;279:50643-6 pubmed
    ..Here we have identified annexin 1 as a substrate for TRPM7 kinase...
  45. Khau T, Langenbach S, Schuliga M, Harris T, Johnstone C, Anderson R, et al. Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. FASEB J. 2011;25:483-96 pubmed publisher
    The role of the calcium- and phospholipid-binding protein annexin I (ANXA1) in cell cycle regulation has been investigated in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast tumor cell lines...
  46. Zhang L, Yang X, Zhong L, Zhou X, Pan H, Wei K, et al. Decreased expression of Annexin A1 correlates with pathologic differentiation grade in oral squamous cell carcinoma. J Oral Pathol Med. 2009;38:362-70 pubmed publisher
    ..In this study, comparative proteomic analysis identified that Annexin A1 was one of the significantly down-regulated genes in the cancerous HB96 cells...
  47. Lin C, Jeng Y, Chou H, Hsu H, Yuan R, Chiang C, et al. Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma. J Surg Oncol. 2008;97:544-50 pubmed publisher
    To investigate whether annexin A1 (ANXA1) expression is a marker in predicting the prognosis of oral cancer patients...
  48. Silistino Souza R, Rodrigues Lisoni F, Cury P, Maniglia J, Raposo L, Tajara E, et al. Annexin 1: differential expression in tumor and mast cells in human larynx cancer. Int J Cancer. 2007;120:2582-9 pubmed
    b>Annexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium...
  49. Zhu F, Xu C, Jiang Z, Jin M, Wang L, Zeng S, et al. Nuclear localization of annexin A1 correlates with advanced disease and peritoneal dissemination in patients with gastric carcinoma. Anat Rec (Hoboken). 2010;293:1310-4 pubmed publisher
    b>Annexin A1 (ANXA1) is a multifunctional molecule, which mediates various important physiologic processes depending on its subcelluar localization...
  50. Gil C, La M, Perretti M, Oliani S. Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. Cell Biol Int. 2006;30:338-44 pubmed
    b>Annexin 1 (ANXA1), galectin-1 (Gal-1) and galectin-3 (Gal-3) proteins have been identified as important mediators that promote or inhibit leukocyte migration...
  51. Hsiang C, Tunoda T, Whang Y, Tyson D, Ornstein D. The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells. Prostate. 2006;66:1413-24 pubmed
    Although reduced expression levels of annexin I (ANX I) protein is a common finding in all stages of prostate cancer a causative relationship between ANX I dysregulation and prostate cancer development has yet to be established...
  52. He Z, Wen H, Shi C, Wang J. Up-regulation of hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer. World J Gastroenterol. 2010;16:4670-6 pubmed
    ..metastasis-concerned proteins highly expressed in SLNMM were identified to be hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1. Further immunohistochemistry staining of these four proteins showed their clinicopathological characteristics ..
  53. Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, Rescher U. An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. J Immunol. 2004;172:7669-76 pubmed
    ..In this study we show that a peptide derived from the N-terminal domain of the anti-inflammatory protein annexin 1 (lipocortin 1) can activate all three FPR family members at similar concentrations...
  54. Guzman Aranguez A, Olmo N, Turnay J, Lecona E, Pérez Ramos P, Lopez de Silanes I, et al. Differentiation of human colon adenocarcinoma cells alters the expression and intracellular localization of annexins A1, A2, and A5. J Cell Biochem. 2005;94:178-93 pubmed
    ..Thus, we have analyzed changes in annexin A1 (AnxA1), annexin A2 (AnxA2), and annexin A5 (AnxA5) levels and localization in human colon adenocarcinoma cells ..
  55. Herbert S, Odell A, Ponnambalam S, Walker J. The confluence-dependent interaction of cytosolic phospholipase A2-alpha with annexin A1 regulates endothelial cell prostaglandin E2 generation. J Biol Chem. 2007;282:34468-78 pubmed
    ..Golgi apparatus of confluent endothelial cells, cPLA(2)alpha is associated with the phospholipid-binding protein annexin A1. Furthermore, the siRNA-mediated knockdown of endogenous annexin A1 significantly reverses the inhibitory effect ..
  56. Hongsrichan N, Rucksaken R, Chamgramol Y, Pinlaor P, Techasen A, Yongvanit P, et al. Annexin A1: A new immunohistological marker of cholangiocarcinoma. World J Gastroenterol. 2013;19:2456-65 pubmed publisher
    To evaluate a new immunohistological marker, annexin A1 (ANXA1), in cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC)...
  57. Liu Y, Wang H, Lu N, Mao Y, Liu F, Wang Y, et al. Translocation of annexin I from cellular membrane to the nuclear membrane in human esophageal squamous cell carcinoma. World J Gastroenterol. 2003;9:645-9 pubmed
    To investigate the alteration of the annexin I subcellular localization in esophageal squamous cell carcinoma (ESCC) and the correlation between the translocation and the tumorigenesis of ESCC...
  58. Rescher U, Goebeler V, Wilbers A, Gerke V. Proteolytic cleavage of annexin 1 by human leukocyte elastase. Biochim Biophys Acta. 2006;1763:1320-4 pubmed
    b>Annexin 1 has been shown to participate through its unique N-terminal domain in the recruitment and activation of leukocytes at sites of inflammation...
  59. Nair S, Hande M, Lim L. Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage. Cancer Lett. 2010;294:111-7 pubmed publisher
    ..This study demonstrates that ANXA1, which we recently reported as a possible tumor suppressor gene, can protect cells from heat-induced growth arrest and DNA damage. ..
  60. Bizzarro V, Fontanella B, Carratù A, Belvedere R, Marfella R, Parente L, et al. Annexin A1 N-terminal derived peptide Ac2-26 stimulates fibroblast migration in high glucose conditions. PLoS ONE. 2012;7:e45639 pubmed publisher
    ..In this study, we have evaluated whether Annexin A1 derived peptide Ac2-26 stimulates fibroblast migration in high glucose conditions...
  61. Perretti M, D Acquisto F. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol. 2009;9:62-70 pubmed publisher
    ..In this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in ..
  62. Babbin B, Lee W, Parkos C, Winfree L, Akyildiz A, Perretti M, et al. Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem. 2006;281:19588-99 pubmed
    b>Annexin 1 (AnxA1) is a multifunctional phospholipid-binding protein associated with the development of metastasis in some invasive epithelial malignancies...
  63. Dalli J, Norling L, Renshaw D, Cooper D, Leung K, Perretti M. Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood. 2008;112:2512-9 pubmed publisher
    ..cells as assessed in vitro; since PMNs contain abundant amounts of the endogenous anti-inflammatory protein annexin 1 (AnxA1), we tested here whether biologically active AnxA1 could be present in PMN-derived microparticles...
  64. Sena A, Grishina I, Thai A, Goulart L, Macal M, Fenton A, et al. Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease. PLoS ONE. 2013;8:e76969 pubmed publisher
    ..However, the role of immunomodulatory factors such as annexin A1 (ANXA1) is not well understood...