ANKS1B

Summary

Gene Symbol: ANKS1B
Description: ankyrin repeat and sterile alpha motif domain containing 1B
Alias: AIDA, AIDA-1, ANKS2, EB-1, EB1, cajalin-2, E2a-Pbx1-associated protein, amyloid-beta precursor protein intracellular domain associated protein 1, ankyrin repeat and sterile alpha motif domain-containing protein 1B, cajalin 2
Species: human

Top Publications

  1. ncbi Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner
    Enrico Ghersi
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Biol Chem 279:49105-12. 2004
  2. doi A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import
    Arwa Kurabi
    Department of Biology, York University, Toronto, Ontario, Canada
    J Mol Biol 392:1168-77. 2009
  3. ncbi EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1
    X Fu
    Department of Pathology, University of California, San Diego, California, USA
    Oncogene 18:4920-9. 1999
  4. ncbi The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line
    Giovanna Casagrande
    Laboratory of Hematology and Oncology, Department of Pediatrics, University of Padova, Italy
    Haematologica 91:765-71. 2006
  5. pmc Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 99:15101-6. 2002
  6. ncbi The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing
    Enrico Ghersi
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Alzheimers Dis 6:67-78. 2004
  7. doi Safety of raw meat and shellfish in Vietnam: an analysis of Escherichia coli isolations for antibiotic resistance and virulence genes
    Thi Thu Hao Van
    Biotechnology and Environmental Biology, School of Applied Sciences, RMIT University, Bundoora West Campus, Bundoora, Melbourne, VIC 3083, Australia
    Int J Food Microbiol 124:217-23. 2008
  8. ncbi [A new diagnostic concept in cardiac pacing for the evaluation of the incidence of atrial arrhythmias. Results of the AIDA study]
    P Defaye
    Clinique Cardiologique et Urgences Cardiologiques, CHU Michallon, Grenoble
    Arch Mal Coeur Vaiss 92:719-26. 1999
  9. ncbi Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom
    Eliane Maria Zanchet
    Laboratorio de Fisiopatologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503 900, Sao Paulo, SP, Brazil
    Brain Res 1021:101-11. 2004
  10. ncbi The metabotropic glutamate receptors of the vestibular organs
    P S Guth
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    Hear Res 125:154-62. 1998

Research Grants

Detail Information

Publications148 found, 100 shown here

  1. ncbi Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner
    Enrico Ghersi
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Biol Chem 279:49105-12. 2004
    ..We have recently reported the cloning and characterization of different isoforms of AID associated protein-1 (AIDA-1), a novel AID-binding protein...
  2. doi A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import
    Arwa Kurabi
    Department of Biology, York University, Toronto, Ontario, Canada
    J Mol Biol 392:1168-77. 2009
    The neuronal scaffolding protein AIDA-1 is believed to act as a convener of signals arising at postsynaptic densities...
  3. ncbi EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1
    X Fu
    Department of Pathology, University of California, San Diego, California, USA
    Oncogene 18:4920-9. 1999
    ..Potentially, EB-1 overexpression could interfere with normal signaling controlling proliferation or differentiation...
  4. ncbi The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line
    Giovanna Casagrande
    Laboratory of Hematology and Oncology, Department of Pediatrics, University of Padova, Italy
    Haematologica 91:765-71. 2006
    ..The role of this fusion gene during leukemogenesis is not yet fully understood; one approach to investigate its function is to selectively deplete the E2A-PBX1 protein and examine the consequences...
  5. pmc Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 99:15101-6. 2002
    ....
  6. ncbi The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing
    Enrico Ghersi
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Alzheimers Dis 6:67-78. 2004
    ..cloning and initial characterization of two isoforms of a novel protein that we named AID Associated protein-1a (AIDA-1a), AIDA-1b and AIDA-1bDeltaAnk...
  7. doi Safety of raw meat and shellfish in Vietnam: an analysis of Escherichia coli isolations for antibiotic resistance and virulence genes
    Thi Thu Hao Van
    Biotechnology and Environmental Biology, School of Applied Sciences, RMIT University, Bundoora West Campus, Bundoora, Melbourne, VIC 3083, Australia
    Int J Food Microbiol 124:217-23. 2008
    ..Virulence genes detected were fimH (92.1%), bmaE (84.2%), TSPE4.C2 (42.1%), aidA AIDA-I (orfB) (31.6%), east1 (26.3%), traT (23.7%), and others including fyuA, iutA, chuA, yjaA, iss, iroN(E...
  8. ncbi [A new diagnostic concept in cardiac pacing for the evaluation of the incidence of atrial arrhythmias. Results of the AIDA study]
    P Defaye
    Clinique Cardiologique et Urgences Cardiologiques, CHU Michallon, Grenoble
    Arch Mal Coeur Vaiss 92:719-26. 1999
    An international, prospective, multicentre trial (AIDA) was undertaken from October 1995 to March 1997...
  9. ncbi Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom
    Eliane Maria Zanchet
    Laboratorio de Fisiopatologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503 900, Sao Paulo, SP, Brazil
    Brain Res 1021:101-11. 2004
    ..CGRP8-37) and N-methyl-D-aspartate (NMDA; MK 801 and AP-5), non-NMDA ionotropic (CNQX), or metabotropic (AIDA and MPEP) glutamate receptor antagonists, suggesting the involvement of spinal neurokinins and excitatory amino ..
  10. ncbi The metabotropic glutamate receptors of the vestibular organs
    P S Guth
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    Hear Res 125:154-62. 1998
    ..by the Group I mGluR antagonists (S)-4-carboxyphenylglycine (CPG) and (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA). Additional pharmacological evidence supported the presence of Group I mGluRs...
  11. doi Expression analysis of selected immune-relevant genes in channel catfish during Edwardsiella ictaluri infection
    Banu Elibol-Flemming
    Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762, USA
    J Aquat Anim Health 21:23-35. 2009
    ..End-binding protein 1 (EB1), beta1-integrin, natural-resistance-associated macrophage protein (Nramp), heat shock protein 70 (Hsp70), serum ..
  12. ncbi Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei
    Silvarosa Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Via del Giochetto, I 06126 Perugia, Italy
    Eur J Neurosci 26:23-32. 2007
    ..acid (AP-5)] and group I metabotropic glutamate receptors (mGlu-I) [(R,S)-1-aminoindan-1,5-dicarboxylic acid (AIDA)] receptors...
  13. pmc Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function
    Jongdae Shin
    Department of Biological Science, Sookmyung Women s University, Chungpa dong 2 Ka, Yongsan Ku, Seoul 140 742, South Korea
    Mol Cell Biol 27:8113-26. 2007
    ..Here we show that the phosphotyrosine binding (PTB) domain-containing proteins AIDA-1b and Odin are tightly associated with the EphA8 receptor in response to ligand stimulation...
  14. pmc A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering
    P Karna
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Cell Death Differ 18:632-44. 2011
    ..of microtubule dynamics was associated with impaired association of microtubule plus-end tracking proteins, such as EB1 and CLIP-170...
  15. pmc Cryo-electron tomography of microtubule-kinesin motor complexes
    Julia Cope
    The Boulder Laboratory for 3 D Microscopy of Cells, University of Colorado at Boulder, Department of Molecular, Cellular, and Developmental Biology, Boulder, CO 80309 0347, USA
    J Struct Biol 170:257-65. 2010
    ..with molecular motors of the kinesin family or non-motor microtubule associated proteins (MAPs) such as tau or EB1 have been the subject of cryo-electron microcopy based 3-D studies for several years...
  16. ncbi The role of striatal metabotropic glutamate receptors in Parkinson's disease
    K Ossowska
    Department of Neuro Psychopharmacology, Institute of Pharmacology, kraksów, Poland
    Amino Acids 23:193-8. 2002
    ..Intrastriatal injections of the mGluR1 antagonist, (RS) AIDA (7.5-15 microg/0.5 microl), but not of the agonist of group II mGluRs, 2R,4R-APDC (7.5-15 microg/0...
  17. pmc Organization of amyloid-beta protein precursor intracellular domain-associated protein-1 in the rat brain
    Amanda L Jacob
    Curriculum in Neurobiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Comp Neurol 518:3221-36. 2010
    ..Amyloid-beta protein precursor intracellular domain-associated protein-1 (AIDA-1), an abundant component of the biochemical postsynaptic density fraction, contains a nuclear localization ..
  18. ncbi Out-patient management of acute myeloid leukemia after consolidation chemotherapy. Role of a hematologic emergency unit
    C Girmenia
    Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Via Benevento 6, 00161, Rome, Italy
    Haematologica 84:814-9. 1999
    ..The aim of this prospective study was to evaluate feasibility and safety, as well as clinical characteristics, of out-hospital management of AML patients during their post-consolidation phase...
  19. ncbi Length control of the metaphase spindle
    Gohta Goshima
    Physiology Course 2004, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Curr Biol 15:1979-88. 2005
    ..Although a number of molecular perturbations have been shown to influence spindle length, a global understanding of the factors that determine metaphase spindle length has not been achieved...
  20. doi Evaluation of technetium Tc 99m-labeled biotin for scintigraphic detection of soft tissue inflammation in horses
    Lauren G Kleine
    Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
    Am J Vet Res 69:639-46. 2008
    To evaluate the use of technetium Tc 99m-labeled EDTA-biotin monomer ((99m)Tc-EB1) as a scintigraphic imaging agent for soft tissue inflammatory lesions in horses.
  21. doi Differential roles of peripheral metabotropic glutamate receptors in bee venom-induced nociception and inflammation in conscious rats
    Hui Sheng Chen
    Department of Neurology, General Hospital of Shen Yang Military Region, Shenyang 110016, PR China
    J Pain 11:321-9. 2010
    ..We determined the effects of the group I mGluR antagonist AIDA, the group II mGluR agonist ADPC, and the group III mGluR agonist L-AP4 on BV-induced PSN, mechanical hyperalgesia, ..
  22. ncbi The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules
    Y Mimori-Kiyosue
    Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Shimogyo ku, 600 8813, Japan
    Curr Biol 10:865-8. 2000
    ..b>EB1, which was identified as an APC-binding protein by yeast two-hybrid analysis [5], was also reported to be ..
  23. pmc Kinesin-13 regulates flagellar, interphase, and mitotic microtubule dynamics in Giardia intestinalis
    Scott C Dawson
    Department of Molecular and Cell Biology, University of California Berkeley, 341 LSA Bldg, Berkeley, California 94720, USA
    Eukaryot Cell 6:2354-64. 2007
    ..Both green fluorescent protein-tagged kinesin-13 and EB1 (a plus-end tracking protein) localize to the plus ends of mitotic and interphase microtubules, including a novel ..
  24. doi Anti-heart and anti-intercalated disk autoantibodies: evidence for autoimmunity in idiopathic recurrent acute pericarditis
    A L P Caforio
    Division of Cardiology, Department of Cardiological, Thoracic and Vascular Sciences, Centro V Gallucci, University of Padova Policlinico, Via Giustiniani, 2, Padova 35128, Italy
    Heart 96:779-84. 2010
    ..Objective To assess frequency of serum anti-heart (AHA), anti-intercalated-disk (AIDA) and non-cardiac-specific autoantibodies and their clinical and instrumental correlates in patients with IRAP...
  25. ncbi Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 281:17140-9. 2006
    ..This sequence lacks DLG-1 and EB1 binding sites, suggesting that these partners are not absolutely required for APC membrane targeting...
  26. ncbi Using micellar mole fractions to assess membrane protein stability in mixed micelles
    P Sehgal
    Department of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, DK 9000 Aalborg, Denmark
    Biochim Biophys Acta 1716:59-68. 2005
    ..an extensive analysis of the thermal stability of the membrane-integrated domain of the outer membrane protein AIDA in the presence of different mixed micelles...
  27. pmc EB1 targets to kinetochores with attached, polymerizing microtubules
    Jennifer S Tirnauer
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Biol Cell 13:4308-16. 2002
    ..The plus end tracking protein EB1 is required both for regulating microtubule dynamics and for maintaining a euploid genome...
  28. ncbi Dopamine receptors and groups I and II mGluRs cooperate for long-term depression induction in rat prefrontal cortex through converging postsynaptic activation of MAP kinases
    S Otani
    Laboratoire de Neurobiologie et Neuropharmacologie du Developpement, Institut des Neurosciences, Universite de Paris VI, 75005 Paris, France
    J Neurosci 19:9788-802. 1999
    ..S)-alpha-methyl-4-carboxyphenylglycine (MCPG; group I and II antagonist), (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; group I antagonist), or (RS)-alpha-methylserine-O-phosphate monophenyl ester (MSOPPE; group II antagonist)...
  29. ncbi Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice
    C Thomsen
    Novo Nordisk A S, Health Care Discovery, Måløv, Denmark
    Neuropharmacology 37:1465-73. 1998
    ..The group I mGluR antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) dose-dependently antagonised PTZ-induced seizures with a mean ED50 value of 465 nmol...
  30. ncbi Isolation of the first metallo-beta-lactamase producing Klebsiella pneumoniae in Lebanon
    Z Daoud
    Clinical Microbiology Laboratory, Saint George University Hospital, Faculty of Health Sciences, University of Balamand, Beirut, Lebanon
    Rev Esp Quimioter 21:123-6. 2008
    A 58 year-old man was admitted to the Saint Joseph Hospital-Raymond and Aida Najjar polyclinic in Beirut on July 17, 2007 to undergo surgery for a moderately differentiated colonic adenocarcinoma (T3N0)...
  31. doi SOCIC: the store-operated calcium influx complex
    Luis Vaca
    Departamento de Biologia Celular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Del Coyoacan, 04510 Mexico, DF, Mexico
    Cell Calcium 47:199-209. 2010
    ..calcium influx complex (SOCIC), such as the TRPC1 channel, SERCA and the microtubule end tracking protein, EB1. An orchestrated series of events involving the association and dissociation of several protein complexes culminate ..
  32. pmc Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
    R Smits
    Medical Genetics Center MGC Department of Human Genetics, Leiden University Medical Center, 2300 RA Leiden, The Netherlands
    Genes Dev 13:1309-21. 1999
    ..In addition, they lack the carboxy-terminal domains that bind to DLG, EB1, and microtubulin...
  33. ncbi CD56 expression is an indicator of poor clinical outcome in patients with acute promyelocytic leukemia treated with simultaneous all-trans-retinoic acid and chemotherapy
    F Ferrara
    Divisione di Ematologia, Sezione TERE, Servizio di Immunoematologia, Ospedale Cardarelli, Naples, Italy
    J Clin Oncol 18:1295-300. 2000
    ..We investigated the prognostic relevance of CD56 in a series of patients with APL who were treated homogeneously with all-trans-retinoic acid (ATRA) and chemotherapy...
  34. pmc O-linked glycosylation ensures the normal conformation of the autotransporter adhesin involved in diffuse adherence
    Marie Eve Charbonneau
    Universite de Montreal, Faculte de Medecine Veterinaire, 3200 Sicotte, St Hyacinthe, Quebec J2S 7C6, Canada
    J Bacteriol 189:8880-9. 2007
    The Escherichia coli adhesin involved in diffuse adherence (AIDA-I) is one of the few glycosylated proteins found in Escherichia coli...
  35. ncbi The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous tubules
    Fubin Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Exp Cell Res 314:213-26. 2008
    ..Moreover, compared to other microtubule plus end-tracking proteins such as CLIP-170 and p150(Glued), EB1 was highly expressed in Sertoli cells and located along microtubule bundles in Sertoli cell processes...
  36. ncbi Regulated binding of adenomatous polyposis coli protein to actin
    James B Moseley
    Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA
    J Biol Chem 282:12661-8. 2007
    ..third of APC protein mediates direct interactions with microtubules and the microtubule plus-end tracking protein EB1. In addition, APC has been localized to actin-rich regions of cells, but the mechanism and functional significance ..
  37. ncbi Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups
    M A Sanz
    Hospital Universitario La Fe, Valencia, Spain
    Blood 96:1247-53. 2000
    ..All patients received identical induction (AIDA schedule) and maintenance...
  38. ncbi Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus
    Feng Ru Tang
    Epilepsy Research Lab, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore
    Neuropharmacology 53:821-31. 2007
    ..antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to ..
  39. pmc Endogenous sulphur-containing amino acids: potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system
    M J Croucher
    Department of Neuroinflammation, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF
    Br J Pharmacol 133:815-24. 2001
    ..with the inactivity of the selective mGlu1 receptor antagonists, (R,S)-1-aminoindan-1,5-dicarboxylic acid ((R,S)-AIDA; 100 - 500 microM) and the more potent (+)-2-methyl-4-carboxyphenylglycine (LY367385; 10 microM) against these ..
  40. ncbi Excimer laser trabeculotomy: a new, minimally invasive procedure for patients with glaucoma
    Sonja Wilmsmeyer
    Department of Ophthalmology, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany
    Graefes Arch Clin Exp Ophthalmol 244:670-6. 2006
    ..Our purpose was to examine IOP reduction and the use of antiglaucoma drugs (AGD) in patients treated with ELT and to evaluate the safety of this laser treatment...
  41. ncbi Therapy of molecular relapse in acute promyelocytic leukemia
    F Lo Coco
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita La Sapienza, Rome, Italy
    Blood 94:2225-9. 1999
    ..All patients had achieved first molecular remission after the AIDA protocol (all-trans retinoic acid [ATRA] + idarubicin) and were being prospectively monitored by reverse ..
  42. pmc Melanophilin and myosin Va track the microtubule plus end on EB1
    Xufeng S Wu
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 171:201-7. 2005
    ..Data showing that overexpression and short inhibitory RNA knockdown of the +TIP EB1 have opposite effects on Mlp-microtubule interaction, that Mlp interacts directly with EB1, and that deletion from ..
  43. pmc Centrosome maturation: measurement of microtubule nucleation throughout the cell cycle by using GFP-tagged EB1
    Michelle Piehl
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    Proc Natl Acad Sci U S A 101:1584-8. 2004
    ..To view nucleation in living cells, we imaged GFP-tagged EB1, a microtubule tip-binding protein, and determined rates of nucleation by counting the number of EB1-GFP comets ..
  44. ncbi Contribution of microtubule growth polarity and flux to spindle assembly and functioning in plant cells
    Pankaj Dhonukshe
    Section of Molecular Cytology and Centre for Advanced Microscopy, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 316, 1098 SM Amsterdam, The Netherlands
    J Cell Sci 119:3193-205. 2006
    ..the dynamics of spindle formation in acentrosomal plant cells by visualizing microtubules labelled with GFP-EB1, GFP-MAP4 and GFP-alpha-tubulin and chromosomes marked by the vital dye SYTO82...
  45. doi Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat
    Kazuto Yoshimi
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe cho, Sakyo ku, Kyoto, Japan
    Cancer Sci 100:2022-7. 2009
    ..The truncated APC of the KAD rat was deduced to lack part of the basic domain, an EB1-binding domain, and a PDZ domain, but retained an intact beta-catenin binding region...
  46. pmc Organization and dynamics of growing microtubule plus ends during early mitosis
    Michelle Piehl
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Mol Biol Cell 14:916-25. 2003
    A stable cell line expressing EB1-green fluorescent protein was used to image growing microtubule plus ends at the G(2)/M transition...
  47. ncbi GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children
    Anna Maria Testi
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita La Sapienza, Via Benevento 6, 00161 Rome, Italy
    Blood 106:447-53. 2005
    ..Italiano per le Malattie Ematologiche dell'Adulto (GIMEMA)-Italian Pediatric Hematology and Oncology Group (AIEOP) "AIDA" (ATRA and idarubicin) trial are presented...
  48. pmc Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells
    V M Draviam
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    EMBO J 25:2814-27. 2006
    ..that RNAi-mediated depletion of two kMAPs, the adenomatous polyposis coli protein (APC) and its binding partner, EB1, are unusual in affecting the movement and orientation of paired sister chromatids at the metaphase plate without ..
  49. ncbi An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats
    K Ossowska
    Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Amino Acids 32:179-88. 2007
    ..Systemic or intrastriatal administration of group I mGluR antagonists (mGluR5 - MPEP, MTEP; mGluR1 - AIDA) was found to inhibit parkinsonian-like symptoms (catalepsy, muscle rigidity) in rats...
  50. ncbi Glycosylation with heptose residues mediated by the aah gene product is essential for adherence of the AIDA-I adhesin
    I Benz
    Institut für Infektiologie Zentrum für Molekularbiologie der Entzündung ZMBE, Universitatsklinikum Munster, Germany
    Mol Microbiol 40:1403-13. 2001
    The diffuse adherence of Escherichia coli strain 2787 (O126:H27) is mediated by the autotransporter adhesin AIDA-I (adhesin-involved-in-diffuse-adherence) encoded by the plasmid-borne aidA gene...
  51. ncbi Isolation and identification of AIDA-I receptors in porcine intestinal mucus
    Y Fang
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, Canada S7N 5B4
    Vet Microbiol 126:345-55. 2008
    Porcine AIDA-I positive Escherichia coli causes diarrhea in neonatal piglets and AIDA-I adhesin is an important virulence factor involved in intestinal colonization with biofilm formation. This biofilm consists of AIDA-I(+)E...
  52. ncbi Characterization of functional domains of human EB1 family proteins
    Wen Bu
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:49721-31. 2003
    b>EB1 family proteins are evolutionarily conserved proteins that bind microtubule plus-ends and centrosomes and regulate the dynamics and organization of microtubules...
  53. pmc Peptide mimics selected from immune sera using phage display technology can replace native antigens in the diagnosis of Epstein-Barr virus infection
    J L Casey
    AdAlta Pty Ltd, 15 2 Park Drive, Bundoora, VIC 3083, Australia
    Protein Eng Des Sel 22:85-91. 2009
    ..We selected four peptides (Eb1-4) with the highest relative binding affinity with immune rabbit sera and a single peptide with high affinity to ..
  54. pmc EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules
    Jennifer S Tirnauer
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Biol Cell 13:3614-26. 2002
    b>EB1 targets to polymerizing microtubule ends, where it is favorably positioned to regulate microtubule polymerization and confer molecular recognition of the microtubule end...
  55. ncbi DNA sequences coding for the F18 fimbriae and AIDA adhesin are localised on the same plasmid in Escherichia coli isolates from piglets
    Jacques G Mainil
    Chaire de Bactériologie et de Pathologie des Maladies Bactériennes, Faculte de Medecine Veterinaire, Universite de Liege, Liege, Belgium
    Vet Microbiol 86:303-11. 2002
    The adhesin-involved-in-diffuse-adherence (AIDA) afimbrial adhesin is produced by human, but not by animal, Escherichia coli, with the exception of German porcine verotoxigenic Escherichia coli (VTEC) [Clin. Diagn. Lab. Immunol...
  56. ncbi Examination of Escherichia coli from poultry for selected adhesin genes important in disease caused by mammalian pathogenic E. coli
    P Stordeur
    Departement de Bactériologie et de Pathologie Bactérienne, Faculte de Medecine Veterinaire, Universite de Liege, Campus du Sart Tilman, Bât B43a, B4000, Liege, Belgium
    Vet Microbiol 84:231-41. 2002
    ..specific for fimbrial and afimbrial adhesins (F17, F18, S <Sfa/F1C>, Bfp, Afa, Cs31A, Intimin <Eae>, Aida-1) of intestinal, urinary and invasive E...
  57. doi Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1
    Eulalia Pozo-Guisado
    Department of Biochemistry and Molecular Biology, College of Life Sciences, University of Extremadura, Badajoz 06006, Spain
    J Cell Sci 126:3170-80. 2013
    ..This phosphorylation occurs in parallel to the dissociation from end-binding protein 1 (EB1), a regulator of growing microtubule ends...
  58. doi The microtubule end-binding protein EB2 is a central regulator of microtubule reorganisation in apico-basal epithelial differentiation
    Deborah A Goldspink
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
    J Cell Sci 126:4000-14. 2013
    ..Here, we establish for the first time that expression of EB2, but not that of EB1, is crucial for initial microtubule reorganisation during apico-basal epithelial differentiation, and that EB2 ..
  59. doi Depletion of end-binding protein 1 (EB1) promotes apoptosis of human non-small-cell lung cancer cells via reactive oxygen species and Bax-mediated mitochondrial dysfunction
    Min Jung Kim
    Division of Radiation Cancer Biology, Korea Institute of Radiological and Medical Sciences, Seoul 139 706, Republic of Korea
    Cancer Lett 339:15-24. 2013
    Although end-binding protein 1 (EB1) is well known to regulate microtubule dynamics, the role of EB1 in apoptosis of non-small cell lung cancer (NSCLC) is poorly understood...
  60. pmc Purification, crystallization and preliminary X-ray crystallographic analysis of the transport unit of the monomeric autotransporter AIDA-I from Escherichia coli
    Iris Gawarzewski
    Institute of Biochemistry, Heinrich Heine Universitat, Dusseldorf, Germany
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:1159-62. 2013
    The adhesin involved in diffuse adherence (AIDA-I) from Escherichia coli belongs to the group of autotransporters, specifically the type Va secretion system (T5aSS)...
  61. ncbi The Escherichia coli AIDA autotransporter adhesin recognizes an integral membrane glycoprotein as receptor
    Sven Laarmann
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Westfalische Wilhelms Universitat Munster, Von Esmarch Str 56, 48149 Munster, Germany
    Microbiology 149:1871-82. 2003
    The AIDA-I autotransporter adhesin, as a prototype of the AIDA adhesin family, represents a tripartite antigen consisting of the functional adhesin AIDA-I (alpha-domain), which mediates the specific attachment of bacteria to target cells, ..
  62. pmc Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex
    A E Bandrowski
    Department of Neurology, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurophysiol 89:1308-16. 2003
    ..acid (LY341495, a group II antagonist) increased, but R(-)-1-amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid (AIDA) and (RS)-hexyl-HIBO (group I antagonists) decreased sEPSC amplitude, and (R,S)-alpha-cyclopropyl-4-..
  63. pmc Autodisplay: development of an efficacious system for surface display of antigenic determinants in Salmonella vaccine strains
    Uwe Kramer
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitat Tubingen, D 72076 Tubingen, Germany
    Infect Immun 71:1944-52. 2003
    ..targeting of heterologous antigens or fragments thereof to the bacterial surface by the autotransporter domain of AIDA-I, the Escherichia coli adhesin involved in diffuse adherence...
  64. ncbi Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain
    Charles D Mills
    Department of Anatomy and Neurosciences, University of Texas Medical Branch at Galveston, 77555 1043, USA
    J Neurotrauma 19:23-42. 2002
    ..To evaluate subtypes of group I mGluRs in SCI, we administered AIDA (group I antagonist), LY 367385 (mGluR1 specific antagonist), or MPEP (mGluR5 specific antagonist) by interspinal ..
  65. ncbi A novel function for the Epstein-Barr virus transcription factor EB1/Zta: induction of transcription of the hIL-10 gene
    Segolene Mahot
    Laboratoire de Virologie Moleculaire et Structurale, UPRES EA2939, GDR CNRS 2372, Universite Joseph Fourier Grenoble I, 38706 La Tronche, France
    J Gen Virol 84:965-74. 2003
    ..In this study, we show that in B cells the viral transcription factor EB1, which is the main inducer of the EBV productive cycle, also activates transcription of the hIL-10 gene and ..
  66. pmc Invasion activity of a Mycobacterium tuberculosis peptide presented by the Escherichia coli AIDA autotransporter
    Nicola Casali
    School of Public Health, University of California at Berkeley, 94720, USA
    Infect Immun 70:6846-52. 2002
    ..A 72-amino-acid fragment (InvX) incorporating this active peptide was expressed in E. coli as a fusion to the AIDA (adhesin involved in diffuse adherence) autotransporter translocator, and its stable expression on the surface of ..
  67. pmc Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes
    Ryan K Louie
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 117:1117-28. 2004
    Adenomatous polyposis coli (APC) and End-binding protein 1 (EB1) localize to centrosomes independently of cytoplasmic microtubules (MTs) and purify with centrosomes from mammalian cell lines...
  68. doi Expression of β-glucuronidase on the surface of bacteria enhances activation of glucuronide prodrugs
    C M Cheng
    Department of Aquaculture, National Kaohsiung Marine University, Kaohsiung, Taiwan
    Cancer Gene Ther 20:276-81. 2013
    ..surface of Escherichia coli by fusion to either the bacterial autotransporter protein Adhesin (membrane βG (mβG)/AIDA) or the lipoprotein (lpp) outermembrane protein A (mβG/lpp)...
  69. ncbi CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms
    Holly V Goodson
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Cell Motil Cytoskeleton 55:156-73. 2003
    ..to growing microtubule plus ends, colocalizing with the dynein activator dynactin and the APC-binding protein EB1. This shared "plus-end tracking" behavior suggests that CLIP-170 might interact with dynactin and/or EB1...
  70. doi EB1 regulates microtubule dynamics and tubulin sheet closure in vitro
    Benjamin Vitre
    Universite de Rennes 1, Centre Nationale de la Recherche Scientifique, Unité Mixte de Recherche 6026, Institut Federatif de Recherche 140, Génétique Fonctionnelle Agronomie et Santé, Campus de Beaulieu, 263, Avenue du General Leclerc, 35042 Rennes, France
    Nat Cell Biol 10:415-21. 2008
    End binding 1 (EB1) is a plus-end-tracking protein (+TIP) that localizes to microtubule plus ends where it modulates their dynamics and interactions with intracellular organelles...
  71. doi Allelic inhibition of displacement activity: a simplified one tube allele-specific PCR for evaluation of ITPA polymorphisms
    E Galmozzi
    First Division of Gastroenterology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    J Virol Methods 187:271-3. 2013
    ..allele discrimination polymerase chain reaction (PCR) assay named allelic inhibition of displacement activity (AIDA) for evaluation of ITPA polymorphisms...
  72. pmc Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin
    Wenjing Li
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Biol 199:849-62. 2012
    ..In Drosophila melanogaster S2 cells, three MT tip-localizing proteins, Msps/XMAP215, EB1, and Sentin (an EB1 cargo protein), have been identified as being critical for accelerating MT growth and promoting ..
  73. pmc EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis
    Peng Xia
    Anhui Key Laboratory of Cellular Dynamics and Hefei National Laboratory for Physical Sciences at Nanoscale, University of Science and Technology of China School of Life Sciences, Hefei 230027, China
    Proc Natl Acad Sci U S A 109:16564-9. 2012
    ..acetyltransferase, acts as a negative modulator of microtubule stability through acetylation of EB1, a protein that controls the plus ends of microtubules...
  74. pmc Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons
    Patrick J Mulholland
    Department of Neurosciences, 67 President Street, Medical University of South Carolina, Charleston, SC 29425, USA
    Alcohol 46:569-76. 2012
    ..One such translational regulatory protein of the postsynaptic density (PSD) is AIDA-1d, which binds to PSD-95 via its C-terminus...
  75. doi Infrared optical constants of crystalline sodium chloride dihydrate: application to study the crystallization of aqueous sodium chloride solution droplets at low temperatures
    Robert Wagner
    Karlsruhe Institute of Technology KIT, Institute for Meteorology and Climate Research IMK AAF, Hermann von Helmholtz Platz 1, D 76344 Eggenstein Leopoldshafen, Germany
    J Phys Chem A 116:8557-71. 2012
    ..from crystallization experiments with airborne particles performed in the large coolable aerosol and cloud chamber AIDA at the Karlsruhe Institute of Technology...
  76. ncbi The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist
    A Kłodzińska
    Department of New Drugs Research, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 55:113-26. 2004
    In the present study we examined the effects of 1-aminoindan-1,5-dicarboxylic acid (AIDA), regarded as a selective and competitive mGluR1 antagonist, in animal models of anxiety. Diazepam (1-10 mg/kg) was used as a reference drug...
  77. pmc Identification and mechanism of evolution of new alleles coding for the AIDA-I autotransporter of porcine pathogenic Escherichia coli
    Jean Philippe Côté
    Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Appl Environ Microbiol 78:4597-605. 2012
    ..The autotransporter adhesin involved in diffuse adherence (AIDA-I) is an outer membrane protein of Escherichia coli, which allows binding to epithelial cells as well as the ..
  78. doi A single mutation in the Japanese encephalitis virus E protein (S123R) increases its growth rate in mouse neuroblastoma cells and its pathogenicity in mice
    Shigeru Tajima
    Department of Virology 1, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
    Virology 396:298-304. 2010
    ..To identify the determinants of its growth nature and pathogenicity, we produced intertypic viruses, rJEV(EB1-M41), rJEV(nEB1-M41) and rJEV(cEB1-M41), which contained the entire, the N-terminal, and the C-terminal half, ..
  79. ncbi Metabotropic glutamate receptor antagonist AIDA blocks induction of mossy fiber-CA3 LTP in vivo
    Kenira J Thompson
    University of Texas at San Antonio, Department of Biology, 6900 N Loop 1604 West, San Antonio, TX 78249, USA
    J Neurophysiol 93:2668-73. 2005
    ..in memory mechanisms, we examined the function of the mGluR-I antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA) on the induction of mossy fiber-CA3 LTP in vivo in male Sprague Dawley and Fischer 344 (F344) rats...
  80. ncbi The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain
    L Berrueta
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachussetts 02115, USA
    Curr Biol 9:425-8. 1999
    Human EB1 is a highly conserved protein that binds to the carboxyl terminus of the human adenomatous polyposis coli (APC) tumor suppressor protein [1], a domain of APC that is commonly deleted in colorectal neoplasia [2]...
  81. pmc Adherence of Escherichia coli O157:H7 mutants in vitro and in ligated pig intestines
    Xianhua Yin
    Guelph Food Research Centre, Ontario, Canada
    Appl Environ Microbiol 75:4975-83. 2009
    ..Therefore, mutants of vt2 and segments of OI-7 and genes aidA(15) (gene from OI-15) and aidA(48) (gene from OI-48) were generated and evaluated for adherence in vitro to ..
  82. doi Modulation of transcription and characterization of the promoter organization of the autotransporter adhesin heptosyltransferase and the autotransporter adhesin AIDA-I
    Inga Benz
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Microbiology 156:1155-66. 2010
    ..The glycosylated autotransporter adhesin involved in diffuse adherence (AIDA)-I system consists of the aah gene, encoding a specific autotransporter adhesin heptosyltransferase (AAH), and the ..
  83. doi STb and AIDA-I: the missing link?
    J Daniel Dubreuil
    Departement de Pathologie et Microbiologie, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Crit Rev Microbiol 36:212-20. 2010
    ..With the recent recognition of a new adhesin, originally found in human E. coli isolates, named AIDA (adhesin involved in diffuse adherence) and its association with new E...
  84. pmc Dendrites differ from axons in patterns of microtubule stability and polymerization during development
    Katherine M Kollins
    Department of Biology, Whitman College, Walla Walla, WA 99362, USA
    Neural Dev 4:26. 2009
    ....
  85. pmc Incorporating a generic model of subcutaneous insulin absorption into the AIDA v4 diabetes simulator. 3. Early plasma insulin determinations
    Eldon D Lehmann
    Department of Imaging MRU, Imperial College of Science, Technology and Medicine NHLI, Royal Brompton Hospital, London, United Kingdom
    J Diabetes Sci Technol 3:190-201. 2009
    b>AIDA is an interactive educational diabetes simulator that has been available without charge via the Internet for over 12 years...
  86. ncbi Role of metabotropic glutamate receptor subclasses in modulation of adenylyl cyclase activity by a nootropic NS-105
    M Hirouchi
    Research Laboratories, Nippon Shinyaku, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto, Japan
    Eur J Pharmacol 387:9-17. 2000
    ..acid (MAP-4), but not by a group I antagonist, (+/-)-1-aminoindan-1,5-dicarboxylic acid (AIDA), whereas the facilitation of cAMP formation by NS-105 (1 microM) in pertussis toxin-pretreated membranes was ..
  87. pmc Probing interactions between CLIP-170, EB1, and microtubules
    Kamlesh K Gupta
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Mol Biol 395:1049-62. 2010
    ..Previous work has shown that CLIP-170 binds to end-binding protein 1 (EB1) via the EB1 C-terminus, which mimics the acidic C-terminal tail of tubulin...
  88. ncbi Characterization and expression of an EB1 protein in Ictalurus punctatus neutrophils
    Y Qian
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599, USA
    Dev Comp Immunol 24:741-50. 2000
    We have identified an EB1 gene (CfEB1) and protein in channel catfish neutrophils. The complete cDNA sequence is 1725 bp and the putative protein is composed of 258 amino acids...
  89. pmc Activity Increase Despite Arthritis (AIDA): design of a Phase II randomised controlled trial evaluating an active management booklet for hip and knee osteoarthritis [ISRCTN24554946]
    Nefyn H Williams
    Department of Primary Care and Public Health, Cardiff University, School of Medicine, North Wales Clinical School, Gwenfro Units 6 7, Wrexham Technology Park, LL13 7YP, UK
    BMC Fam Pract 10:62. 2009
    ..A booklet has been developed for patients with hip or knee osteoarthritis. It focuses on changing disadvantageous beliefs and encouraging increased physical activity...
  90. ncbi Effects of intra-vestibular nucleus injection of the group I metabotropic glutamate receptor antagonist AIDA on vestibular compensation in guinea pigs
    C M Gliddon
    Department of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    Exp Brain Res 134:74-80. 2000
    ..The selective group I mGluR antagonist (RS)-1-aminoindan-1,5,dicarboxylic acid (AIDA) was continuously infused into the ipsilateral VNC for 30-min pre-UVD and 30-min post-UVD by cannula, at a rate of ..
  91. pmc Isolation and characterization of anaerobic ethylbenzene dehydrogenase, a novel Mo-Fe-S enzyme
    H A Johnson
    Environmental Engineering and Science, Department of Civil and Environmental Engineering, Stanford University, Stanford, CA 94305 4020, USA
    J Bacteriol 183:4536-42. 2001
    The first step in anaerobic ethylbenzene mineralization in denitrifying Azoarcus sp. strain EB1 is the oxidation of ethylbenzene to (S)-(-)-1-phenylethanol...
  92. pmc Structuring and extracting knowledge for the support of hypothesis generation in molecular biology
    Marco Roos
    Informatics Institute, University of Amsterdam, Amsterdam, 1098 SJ, The Netherlands
    BMC Bioinformatics 10:S9. 2009
    ..While some tools provide complete solutions that limit the control over the modeling and extraction processes, we seek a methodology that supports control by the experimenter over these critical processes...
  93. pmc Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo
    Karin Wibrand
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Eur J Neurosci 31:636-45. 2010
    ..of the group 1 metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA). AIDA had no effect on LTP induction or maintenance, but blocked activity-dependent depotentiation of LTP...
  94. ncbi Management of acute promyelocytic leukemia relapse in the ATRA era
    C Castagnola
    Divisione di Ematologia, IRCCS Policlinico S Matteo di Pavia, Italy
    Haematologica 83:714-7. 1998
    ..However, management of the few relapses remains undefined. The purpose of the present study was to evaluate the different behavior of APL patients relapsed after induction chemotherapy which had or had not included ATRA...
  95. pmc A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein
    L Muhua
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 393:487-91. 1998
    ..One mutation lies in the gene encoding the yeast homologue of EB1, a human protein that binds the adenomatous polyposis coli (APC) protein, a tumour suppressor...
  96. pmc Treatment of Acute Promyelocytic Leukemia with AIDA Based Regimen. Update of a Tunisian Single Center Study
    Ramzi Jeddi
    Hematology Department, Aziza Othmana University Hospital, Tunis, Tunisia
    Mediterr J Hematol Infect Dis 3:e2011033. 2011
    ..011) and was significantly associated with high BMI (p=0.003). With a median follow-up of 50 months, 5 year cumulative incidence of relapse, event free and overall survival were 4.7%, 74% and 78%, respectively...
  97. pmc Activation of group I mGlu receptors contributes to facilitation of NMDA receptor membrane current in spinal dorsal horn neurons after hind paw inflammation in rats
    Kun Yang
    Department of Neural and Pain Sciences, School of Dentistry and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Eur J Pharmacol 670:509-18. 2011
    ..NMDA-induced current was enhanced in the inflamed rats, compared to naïve rats and this effect was attenuated by AIDA (1 mM), a group I mGlu receptor antagonist...
  98. pmc Kif18B interacts with EB1 and controls astral microtubule length during mitosis
    Jane R Stout
    Medical Sciences Program, Indiana University, Bloomington, IN 47405, USA
    Mol Biol Cell 22:3070-80. 2011
    ..two-hybrid screen identified an interaction of the C-terminal domain of Kif18B with the plus-end MT-binding protein EB1. EB1 knockdown disrupted Kif18B targeting to MT plus ends, indicating that EB1/Kif18B interaction is ..
  99. pmc Dynamics of Kv1 channel transport in axons
    Yuanzheng Gu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio, USA
    PLoS ONE 5:e11931. 2010
    ..Suppressing the Kvbeta2-associated protein, plus-end binding protein EB1 or kinesin II/KIF3A, by siRNA, significantly decreased the velocity of YFP-Kv1.2 moving puncta in both directions...
  100. pmc S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner
    Agnes Grallert
    Cancer Research UK Cell Division Group, Paterson Institute for Cancer Research, Manchester M20 4BX, United Kingdom
    Genes Dev 20:2421-36. 2006
    ..was identified in a screen for mutants with spindle formation defects and a screen for molecules that antagonized EB1 function. The conditional peg1.1 mutant enabled us to identify key features of Peg1 function...
  101. doi Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group
    Francesco Lo-Coco
    Department of Biopathology, University Tor Vergata of Rome, Via Montpellier 1, Rome, Italy
    Blood 116:3171-9. 2010
    ..categories in patients with acute promyelocytic leukemia (APL) receiving all-trans retinoic and idarubicin (AIDA)-like therapies, the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) designed a protocol for newly ..

Research Grants71

  1. Structure and Dynamics of CAP-GLY: Microtubule Assemblies by Solid-State NMR
    JOHN CHARLES WILLIAMS; Fiscal Year: 2010
    ..and dynamics of CAP-Gly domain of dynactin and of its macromolecular assemblies with the microtubules and with EB1 protein...
  2. Dynamic Interactions of the Cytoskeleton
    ERIKA HOLZBAUR; Fiscal Year: 2007
    ..to anchor dynein to adherens junctions, where the motor can can interact with microtubule-plus end proteins such as EB1, CLIP-115, and BPAG-1 (shortstop), and capture and tether microtubule plus ends...
  3. THE CYTOSKELETON AND CELL CYCLE OF YEAST
    John Cooper; Fiscal Year: 2005
    ..This checkpoint depends on the protein EBI. Our studies on how EB1 functions in cells suggest hypotheses for how the checkpoint is activated...
  4. Determining the spindle dynamics regulatory network with an integrated approach
    Ao Ma; Fiscal Year: 2010
    ..along this direction is the recent identification of a network of five regulatory proteins (KLP59C, KLP67A, Mast, EB1 and Msps) that governs kinetochore MT (kMT) plus-end dynamics during metaphase...
  5. T CELL ACTIVATION AND CRYPT CELL APOPTOSIS
    Terrence Barrett; Fiscal Year: 2003
    ..assessment of the mechanisms involved in these pathways will yield new information applicable to IBVD, GVHD, and AIDA enteropathy as well as cancer pathogenesis where a failure in crypt cell apoptosis is involved in early malignant ..
  6. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2003
    ..One of APC's known binding partners is EB1, product of a gene found by the yeast two hybrid interaction trap using APC as bait...
  7. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
    ..that APC'S interactions with three essential postsynaptic components: microtubule plus end binding protein-1 (EB1), beta-catenin and postsynaptic density protein-93 (PSD-93) mediate these essential aspects of synapse formation...
  8. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2007
    ..posit that APC'S interactions with three essential postsynaptic components: microtubule plus end binding protein-1 (EB1), beta-catenin and postsynaptic density protein-93 (PSD-93) mediate these essential aspects of synapse formation...
  9. Light-activated proteolysis as a tool to analyze intracellular protein function
    Torsten Wittmann; Fiscal Year: 2010
    ..test our approach by generating protease-sensitive versions of two multi-domain cytoskeleton proteins, talin and EB1, and by constructing a protease-sensitive kinase domain to demonstrate feasibility and versatility...
  10. Regulation of Microtubules by Rho GTPases
    GREGG GUNDERSEN; Fiscal Year: 2009
    ..We identified mDia, EB1, APC, GSK30 and novel PKCs as factors working downstream of Rho and two separate pathways working downstream of ..
  11. Regulation of Microtubules by Rho GTPases
    GREGG GUNDERSEN; Fiscal Year: 2007
    ..We identified mDia, EB1, APC, GSK3beta and novel PKCs as factors working downstream of Rho and two separate pathways working downstream of ..
  12. ACTIN AND MICROTUBULE-BASED MECHANISMS FOR FUNCTIONS OF NK LYMPHOID CELLS
    John A Cooper; Fiscal Year: 2010
    ..be necessary for the capture of dynamic microtubule plus ends at the lytic synapse, acting in concert with APC and EB1. We will investigate the molecular mechanisms that underlie microtubule capture, using a combination of molecular ..
  13. Regulation of the kinetochore-microtuble interface
    Walter Gall; Fiscal Year: 2006
    ..Preliminary data from my yeast studies suggest Aurora B regulates another MT-associated protein Dim1 (human EB1). EB1 proteins are known to bind and promote stability of plus-end kMTs...
  14. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2002
    ..Several microtubule tip binding proteins have recently been identified. One of these is EB1, the protein on which the K08 proposal referenced above is based...
  15. Regulation of EBV reactivation
    Paul M Lieberman; Fiscal Year: 2010
    ..primary initiator of the EBV lytic cycle is the immediate early protein Zta (also referred to as ZEBRA, BZLF1, and EB1)...
  16. Regulation of EBV reactivation
    Paul Lieberman; Fiscal Year: 2007
    ..primary initiator of the EBV lytic cycle is the immediate early protein Zta (also referred to as ZEBRA, BZLF1, and EB1)...
  17. Polarity establishment during neuronal migration
    Holden Higginbotham; Fiscal Year: 2007
    ..GTPases Cdc42, Rac1, and RhoA, their effector protein IQGAP1, and +TIP microtubule (MT) tracking proteins EB1, CLIP-170 and APC...
  18. Interactions between CLIP-170 and tubulin
    Holly Goodson; Fiscal Year: 2007
    ..abstract_text> ..
  19. Molecular architecture, function and biogenesis of the ventral disc in Giardia in
    Scott Dawson; Fiscal Year: 2009
    ..The research proposed here directly investigates the attachment mechanism of Giardia, and will offer additional targets for drug discovery. Specifically we investigate the function of the "ventral disc" a suction cup-like structure. ..