ANK3

Summary

Gene Symbol: ANK3
Description: ankyrin 3
Alias: ANKYRIN-G, MRT37, ankyrin-3, ankyrin 3, node of Ranvier (ankyrin G)
Species: human
Products:     ANK3

Top Publications

  1. Morgan A, Hamilton G, Turic D, Jehu L, Harold D, Abraham R, et al. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:727-31 pubmed publisher
    ..011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1...
  2. Gella A, Segura M, Durany N, Pfuhlmann B, Stober G, Gawlik M. Is Ankyrin a genetic risk factor for psychiatric phenotypes?. BMC Psychiatry. 2011;11:103 pubmed publisher
    Genome wide association studies reported two single nucleotide polymorphisms in ANK3 (rs9804190 and rs10994336) as independent genetic risk factors for bipolar disorder...
  3. Kizhatil K, Bennett V. Lateral membrane biogenesis in human bronchial epithelial cells requires 190-kDa ankyrin-G. J Biol Chem. 2004;279:16706-14 pubmed
    ..Moreover, analysis of rat 190-kDa ankyrin G/ankyrin B chimeras shows that all three domains of 190-kDa ankyrin-G are required for preservation of the ..
  4. Shirahata E, Iwasaki H, Takagi M, Lin C, Bennett V, Okamura Y, et al. Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6. J Neurophysiol. 2006;96:1347-57 pubmed
    ..6. These results suggest that ankyrin-G regulates neuronal excitability not only through clustering Nav channels but also by directly modifying their channel gating. ..
  5. Kizhatil K, Davis J, Davis L, Hoffman J, Hogan B, Bennett V. Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. J Biol Chem. 2007;282:26552-61 pubmed
    ..Biol. Chem. 282, 2029-2037 ). Together with the current findings, these data suggest a ankyrin/spectrin-based mechanism for coordinating membrane assembly with extracellular interactions of E-cadherin at sites of cell-cell contact. ..
  6. Lowe J, Palygin O, Bhasin N, Hund T, Boyden P, Shibata E, et al. Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. J Cell Biol. 2008;180:173-86 pubmed publisher
    ..These data are the first report of a cellular pathway required for Na(v) channel trafficking in the heart and suggest that ankyrin-G is critical for cardiac depolarization and Na(v) channel organization in multiple excitable tissues. ..
  7. Liu Y, Blackwood D, Caesar S, de Geus E, Farmer A, Ferreira M, et al. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry. 2011;16:2-4 pubmed publisher
  8. Ruberto G, Vassos E, Lewis C, Tatarelli R, Girardi P, Collier D, et al. The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention. PLoS ONE. 2011;6:e16671 pubmed publisher
    ..a strong association with BD in a single nucleotide polymorphism (SNP) (rs10994336) within ANK3, which codes for Ankyrin 3. This protein is involved in facilitating the propagation of action potentials by regulating the assembly of ..
  9. Takata A, Kim S, Ozaki N, Iwata N, Kunugi H, Inada T, et al. Association of ANK3 with bipolar disorder confirmed in East Asia. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:312-5 pubmed publisher
    Results of genome-wide association studies (GWASs) for bipolar disorder (BD) have indicated ANK3 as one of the most promising candidates for a susceptibility gene...

More Information

Publications105 found, 100 shown here

  1. Tesli M, Koefoed P, Athanasiu L, Mattingsdal M, Gustafsson O, Agartz I, et al. Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:969-74 pubmed publisher
    Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD)...
  2. Chen D, Jiang X, Akula N, Shugart Y, Wendland J, Steele C, et al. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Mol Psychiatry. 2013;18:195-205 pubmed publisher
    ..4 × 10(-11) level, with no heterogeneity. Supportive evidence for prior association findings near ANK3 and a locus on chromosome 3p21.1 was also observed...
  3. Rueckert E, Barker D, Ruderfer D, Bergen S, O Dushlaine C, Luce C, et al. Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder. Mol Psychiatry. 2013;18:922-9 pubmed publisher
    Several genome-wide association studies for bipolar disorder (BD) have found a strong association of the Ankyrin 3 (ANK3) gene...
  4. Mohler P, Gramolini A, Bennett V. The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. J Biol Chem. 2002;277:10599-607 pubmed
    ..C-terminal domains are the most divergent between ankyrin isoforms and are candidates to encode the signal(s) that enable ankyrins to selectively target proteins to diverse cellular sites. ..
  5. Kizhatil K, Yoon W, Mohler P, Davis L, Hoffman J, Bennett V. Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. J Biol Chem. 2007;282:2029-37 pubmed
    ..These results demonstrate that ankyrin-G and beta(2)-spectrin are functional partners in biogenesis of the lateral membrane of epithelial cells. ..
  6. Schulze T, Detera Wadleigh S, Akula N, Gupta A, Kassem L, Steele J, et al. Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Mol Psychiatry. 2009;14:487-91 pubmed publisher
    Two recent reports have highlighted ANK3 as a susceptibility gene for bipolar disorder (BD)...
  7. Athanasiu L, Mattingsdal M, Kähler A, Brown A, Gustafsson O, Agartz I, et al. Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res. 2010;44:748-53 pubmed publisher
    ..The markers are located in PLAA, ACSM1 and ANK3, respectively...
  8. Lee M, Chen C, Lee C, Chen C, Chong M, Ouyang W, et al. Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol Psychiatry. 2011;16:548-56 pubmed publisher
    ..15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed ..
  9. Williams H, Craddock N, Russo G, Hamshere M, Moskvina V, Dwyer S, et al. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Hum Mol Genet. 2011;20:387-91 pubmed publisher
    ..For BD, the strongly supported variants are in the vicinity of ankyrin 3, node of Ranvier (ANK3) and polybromo-1 (PBRM1)...
  10. Lett T, Zai C, Tiwari A, Shaikh S, Likhodi O, Kennedy J, et al. ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype. World J Biol Psychiatry. 2011;12:392-7 pubmed publisher
    OBJECTIVES. The ANK3, CACNA1C and ZNF804A genes have been implicated in both bipolar disorders (BPD) and schizophrenia (SCZ)...
  11. Roussos P, Katsel P, Davis K, Bitsios P, Giakoumaki S, Jogia J, et al. Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia. Arch Gen Psychiatry. 2012;69:7-15 pubmed publisher
    ..The effect of the ANK3 genotype on the mRNA expression level was tested in postmortem human brain...
  12. Kloiber S, Czamara D, Karbalai N, Muller Myhsok B, Hennings J, Holsboer F, et al. ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. J Psychiatr Res. 2012;46:973-9 pubmed publisher
    Recent genome-wide association studies (GWAS) and metaanalyses revealed genetic associations for ANK3 (ankyrin 3) and CACNA1C (alpha 1C subunit of the L-type voltage gated calcium channel) with bipolar disorder (BPD)...
  13. Kordeli E, Lambert S, Bennett V. AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J Biol Chem. 1995;270:2352-9 pubmed
    ..The neural-specific ankyrinG polypeptides are candidates to participate in maintenance/targeting of ion channels and cell adhesion molecules to nodes of Ranvier and axonal initial segments. ..
  14. Ferreira M, O Donovan M, Meng Y, Jones I, Ruderfer D, Jones L, et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008;40:1056-8 pubmed publisher
    ..1 x 10(-9)) in ANK3 (ankyrin G)...
  15. Quinn E, Hill M, Anney R, Gill M, Corvin A, Morris D. Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression. Bipolar Disord. 2010;12:440-5 pubmed publisher
    Genome-wide association studies (GWAS) have identified Ankyrin-G (ANK3) and the alpha-1C subunit of the L-type voltage-gated calcium channel (CACNA1C) as susceptibility genes for bipolar disorder...
  16. Roussos P, Giakoumaki S, Georgakopoulos A, Robakis N, Bitsios P. The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. Bipolar Disord. 2011;13:250-9 pubmed publisher
    The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with ..
  17. Dedman A, McQuillin A, Kandaswamy R, Sharp S, Anjorin A, Gurling H. Sequencing of the ANKYRIN 3 gene (ANK3) encoding ankyrin G in bipolar disorder reveals a non-conservative amino acid change in a short isoform of ankyrin G. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:328-35 pubmed publisher
    ..ss469104599) which causes a non-conservative amino acid change at position 794 in the shorter isoforms of the ankyrin G protein...
  18. Wesseling H, Gottschalk M, Bahn S. Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
    ..Finally, we provide new evidence linking ankyrin 3 specifically to affective psychosis and the 22q11...
  19. Saha P, Manoharan P, Arthur S, Sundaram S, Kekuda R, Sundaram U. Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine. Biochim Biophys Acta. 2015;1848:702-11 pubmed publisher
    ..Therefore, altered localization of Na-K-ATPase as a result of transcriptional down-regulation of ankyrin-G mediates the down-regulation of Na-K-ATPase activity during chronic intestinal inflammation. ..
  20. Tai Y, Gallo N, Wang M, Yu J, Van Aelst L. Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM. Neuron. 2019;102:358-372.e9 pubmed publisher
    ..Thus, our findings identify PyN-expressed L1CAM as a critical CAM required for innervation of neocortical PyN AISs by ChCs. VIDEO ABSTRACT. ..
  21. Valente P, Lignani G, Medrihan L, Bosco F, Contestabile A, Lippiello P, et al. Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels. J Cell Sci. 2016;129:1878-91 pubmed publisher
    ..leads to impairment of action potential initiation, most likely due to the loss of the interaction of L1 with ankyrin G that produces the delocalization of Na(+) channels at the axonal initial segment...
  22. Tsushima H, Emanuele M, Polenghi A, Esposito A, Vassalli M, Barberis A, et al. HDAC6 and RhoA are novel players in Abeta-driven disruption of neuronal polarity. Nat Commun. 2015;6:7781 pubmed publisher
    ..the loss of HDAC6 activity perturbs the integrity of axon initial segment (AIS), resulting in mislocalization of ankyrin G and increased MT instability in the AIS concomitant with loss of polarized localization of tau and impairment of ..
  23. Jacko M, Weyn Vanhentenryck S, Smerdon J, Yan R, Feng H, Williams D, et al. Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly. Neuron. 2018;97:853-868.e6 pubmed publisher
    ..We identified an Rbfox-regulated splicing switch in ankyrin G, the AIS "interaction hub" protein, that regulates ankyrin G-beta spectrin affinity and AIS assembly...
  24. Chen X, Lepier A, Berninger B, Tolkovsky A, Herbert J. Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus. PLoS ONE. 2012;7:e31547 pubmed publisher
    ..Moreover, some neurons extended dendrites into the molecular layer, grew axons containing Ankyrin G+ axonal initial segments, and projected into the CA3 region, thus resembling mature DG granule neurons...
  25. van Vliet A, Tannemaat M, van Duinen S, Verhaagen J, Malessy M, De Winter F. Human Neuroma-in-Continuity Contains Focal Deficits in Myelination. J Neuropathol Exp Neurol. 2015;74:901-11 pubmed publisher
    ..e., FMDs contained significantly fewer clustered Na(v)1.6 channels and decreased Caspr and ankyrin G)...
  26. Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
    ..Thus, glial ankyrins function as major scaffolds that facilitate early and efficient paranodal junction assembly in the developing CNS. ..
  27. Kim S, Im W, Shim J, Kim S, Kim B. Static magnetic field controls cell cycle in cultured human glioblastoma cells. Cytotechnology. 2016;68:2745-2751 pubmed
    ..Cdk1 was decreased in proportion to ankyrin G and cyclin B1 (Chi-square test, p = 0.0366)...
  28. Grubb M, Burrone J. Building and maintaining the axon initial segment. Curr Opin Neurobiol. 2010;20:481-8 pubmed publisher
  29. Ghanbari M, de Vries P, de Looper H, Peters M, Schurmann C, Yaghootkar H, et al. A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease. Hum Mutat. 2014;35:1524-31 pubmed publisher
    ..to identify miR-4513 target genes that may mediate these associations and revealed five genes (PCSK1, BNC2, MTMR3, ANK3, and GOSR2) through which these effects might be taking place...
  30. Makara M, Curran J, Little S, Musa H, Polina I, Smith S, et al. Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. Circ Res. 2014;115:929-38 pubmed publisher
    ..5 targeting/regulation in heart. Further, these new data identify the basis of an in vivo cellular platform critical for membrane recruitment and regulation of Nav1.5. ..
  31. Saifetiarova J, Taylor A, Bhat M. Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. J Neurosci. 2017;37:2524-2538 pubmed publisher
    ..One of the molecular components of the node is the cytoskeletal scaffolding protein, ankyrin G (AnkG), which interacts with multiple members of the nodal complex...
  32. Khalid M, Driessen T, Lee J, Tejwani L, Rasool A, Saqlain M, et al. Association of CACNA1C with bipolar disorder among the Pakistani population. Gene. 2018;664:119-126 pubmed publisher
    ..SNPs rs10994336 and rs9804190 in ANK3 and rs1006737 in CACNA1C have emerged as the most highly replicated SNPs significantly associated with BD...
  33. Kloth K, Denecke J, Hempel M, Johannsen J, Strom T, Kubisch C, et al. First de novo ANK3 nonsense mutation in a boy with intellectual disability, speech impairment and autistic features. Eur J Med Genet. 2017;60:494-498 pubmed publisher
    Ankyrin-G, encoded by ANK3, plays an important role in neurodevelopment and neuronal function. There are multiple isoforms of Ankyrin-G resulting in differential tissue expression and function...
  34. Li J, Zhu R, Chen K, Zheng H, Zhao H, Yuan C, et al. Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins. Nat Chem Biol. 2018;14:778-787 pubmed publisher
    ..Thus, these genetically encodable autophagy inhibitory peptides can be used to occlude autophagy spatiotemporally in living animals. ..
  35. Leterrier C, Potier J, Caillol G, Debarnot C, Rueda Boroni F, Dargent B. Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold. Cell Rep. 2015;13:2781-93 pubmed publisher
    ..AIS assembly depends on a ßIV-spectrin/ankyrin G scaffold, but its macromolecular arrangement is not well understood...
  36. Lopez C, Metral S, Eladari D, Drevensek S, Gane P, Chambrey R, et al. The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. J Biol Chem. 2005;280:8221-8 pubmed
  37. Sohet F, Colin Y, Genetet S, Ripoche P, Metral S, Le Van Kim C, et al. Phosphorylation and ankyrin-G binding of the C-terminal domain regulate targeting and function of the ammonium transporter RhBG. J Biol Chem. 2008;283:26557-67 pubmed publisher
    ..All these results led to a model in which targeting and ammonium transport function of RhBG are regulated by both phosphorylation and membrane skeleton binding of the C-terminal cytoplasmic domain. ..
  38. Yuan A, Yi Z, Wang Q, Sun J, Li Z, Du Y, et al. ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:997-1005 pubmed publisher
    ..A genome-wide association study (GWAS) showed a single nucleotide polymorphism (SNP), rs10761482 in ankyrin 3 (ANK3), a major neuron-enriched gene, was associated with schizophrenia although inconsistent results had been ..
  39. Gennarini G, Bizzoca A, Picocci S, Puzzo D, Corsi P, Furley A. The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders. Mol Cell Neurosci. 2017;81:49-63 pubmed publisher
    ..Indeed, thanks to their interactions with Ankyrin G, Na+ channels map within the nodal regions, where they drive axonal depolarization...
  40. Cadwell C, Jenkins P, Bennett V, Kowalczyk A. Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. J Biol Chem. 2016;291:691-704 pubmed publisher
    ..Our findings support a novel mechanism for regulation of VE-cadherin endocytosis through ankyrin association with cadherin engaged in lateral interactions. ..
  41. Fujiwara Y, Kondo H, Shirota M, Kobayashi M, Takeshita K, Nakagawa A, et al. Structural basis for the membrane association of ankyrinG via palmitoylation. Sci Rep. 2016;6:23981 pubmed publisher
    ..This suggests that AnkG in the juxtamembrane region is primed to accept lipid modification at Cys, and once that happens AnkG constitutes a rigid structural base upon which a membrane-excitation platform can be assembled. ..
  42. König H, Watters O, Kinsella S, Ameen M, Fenner B, Prehn J. A constitutively-active IKK-complex at the axon initial segment. Brain Res. 2018;1678:356-366 pubmed publisher
    ..Small-hairpin mediated silencing of IKK? significantly reduced anti-phospho-IKK?/?-immunoreactivities in the AIS. ank3 gene-deficient cerebellar Purkinje cells also exhibited no phosphorylated IKK?/? at the proximal region of their ..
  43. Kretschmer T, England J, Happel L, Liu Z, Thouron C, Nguyen D, et al. Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. Neurosci Lett. 2002;323:151-5 pubmed
    We tested if ankyrin G could be detected in human neuroma, if it colocalized with site-specific peripheral nerve sodium channels that accumulate at axon tips of injured nerve, and if there are differences in the distribution of these ..
  44. Gonzalez S, Xu C, Ramirez M, Zavala J, Armas R, Contreras S, et al. Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations. Transl Psychiatry. 2013;3:e265 pubmed publisher
  45. Kim K, Rutherford M. Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function. J Neurosci. 2016;36:2111-8 pubmed publisher
  46. Cho C, Kim S, Geum D, Lee H. Association analysis of ANK3 variants with bipolar disorder in the Korean population. Nord J Psychiatry. 2017;71:245-249 pubmed publisher
    ..Previous genetic studies of BD have reported several genes as potentially associated with BD. The ANK3 gene has been identified as a possible BD susceptibility gene in genome-wide association analyses...
  47. König H, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, et al. NF-κB regulates neuronal ankyrin-G via a negative feedback loop. Sci Rep. 2017;7:42006 pubmed publisher
    ..We also found that p65 bound to the ank3 (ankyrin-G) promoter sequence in chromatin immunoprecipitation analyses thereby increasing ank3 expression and ..
  48. Zempel H, Dennissen F, Kumar Y, Luedtke J, Biernat J, Mandelkow E, et al. Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture. J Biol Chem. 2017;292:12192-12207 pubmed publisher
    ..The TDB (located within the AIS) was impaired when AIS components (ankyrin G, EB1) were knocked down or when glycogen synthase kinase-3? (GSK3?; an AD-associated kinase tethered to the AIS) ..
  49. Del Rio M, Imam A, DeLeon M, Gomez G, Mishra J, Ma Q, et al. The death domain of kidney ankyrin interacts with Fas and promotes Fas-mediated cell death in renal epithelia. J Am Soc Nephrol. 2004;15:41-51 pubmed
    ..The results identify a novel tethering interaction between ankyrin and Fas in kidney epithelia and suggest that AnkG190 may play a role as an adapter molecule in renal tubule cell death. ..
  50. Perroud N, Uher R, Ng M, Guipponi M, Hauser J, Henigsberg N, et al. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. Pharmacogenomics J. 2012;12:68-77 pubmed publisher
    ..previously associated with psychiatric phenotypes indirectly linked to suicidal behavior, that is, GRIP1, NXPH1 and ANK3. The results suggest novel pathways involved in increasing suicidal ideation during antidepressant treatment and ..
  51. Ota M, Hori H, Sato N, Yoshida F, Hattori K, Teraishi T, et al. Effects of ankyrin 3 gene risk variants on brain structures in patients with bipolar disorder and healthy subjects. Psychiatry Clin Neurosci. 2016;70:498-506 pubmed publisher
    The intronic single-nucleotide polymorphism rs10994336 of the ankyrin 3 gene (ANK3 ) is one of the genome-wide supported risk variants for bipolar disorder (BD), and the T-allele of rs10761482 is also reported to have relevance to BD...
  52. van der Werf I, Van Dam D, Missault S, Yalcin B, De Deyn P, Vandeweyer G, et al. Behavioural characterization of AnkyrinG deficient mice, a model for ANK3 related disorders. Behav Brain Res. 2017;328:218-226 pubmed publisher
    b>ANK3 encodes AnkyrinG (AnkG), a member of the Ankyrin family that is expressed in several different isoforms in many tissues...
  53. Alsayed Y, Modi S, Uddin S, Mahmud N, Druker B, Fish E, et al. All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells. Exp Hematol. 2000;28:826-32 pubmed
  54. Liu Y, Zhang Y, Wang J. Crystal structure of human Ankyrin G death domain. Proteins. 2014;82:3476-82 pubmed publisher
    Ankyrins (Ank) are a ubiquitously expressed family of multifunctional membrane adapter proteins. Ankyrin G (AnkG) is critical for assembling and maintenance of the axon initial segment. Here we present the 2...
  55. D Este E, Kamin D, Balzarotti F, Hell S. Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy. Proc Natl Acad Sci U S A. 2017;114:E191-E199 pubmed publisher
    ..Cytoskeletal proteins of the axon (betaIV spectrin, ankyrin G) exhibit a high degree of one-dimensional longitudinal order at nodal gaps...
  56. Lin X, Lim I, Wu Y, Teh A, Chen L, Aris I, et al. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Med. 2017;15:50 pubmed publisher
    ..Neonatal methylation markers from seven gene loci (ANK3, CDKN2B, CACNA1G, IGDCC4, P4HA3, ZNF423 and MIRLET7BHG) were significantly associated with birth weight, with a ..
  57. Yeon S, Jo Y, Choi E, Kim M, Yoo N, Lee S. Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers. Pathol Oncol Res. 2018;24:617-622 pubmed publisher
    Diminished ANK3 contributes to cell survival by inhibiting detachment-induced apoptosis. TP53BP1 that interacts with p53 and MFN1 that encodes a mitochondrial membrane protein are considered to have tumor suppressor gene (TSG) functions...
  58. Lezmy J, Lipinsky M, Khrapunsky Y, Patrich E, Shalom L, Peretz A, et al. M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment. Proc Natl Acad Sci U S A. 2017;114:E10234-E10243 pubmed publisher
    ..of the spike trigger zone and distal relocation of FGF14, Na+, and Kv7 channels but not ankyrin G. The concomitant distal redistribution of FGF14 together with Nav and Kv7 segments along ..
  59. Morgan A, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, et al. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:762-70 pubmed
    ..candidate genes from our linkage region on chromosome 10 (APBB1IP, ALOX5, AD037, SLC18A3, DKK1, ZWINT, ANK3, UBE2D1, CDC2, SIRT1, JDP1, NET7, SUPV3L1, NEN3, SAR1, SGPL1, SEC24C, CAMK2G, PP3CB, SNCG, CH25H, PLCE1, ANXV111) ..
  60. Wang T, Abou Ouf H, Hegazy S, Alshalalfa M, Stoletov K, Lewis J, et al. Ankyrin G expression is associated with androgen receptor stability, invasiveness, and lethal outcome in prostate cancer patients. J Mol Med (Berl). 2016;94:1411-1422 pubmed
    b>Ankyrin G (ANK3) is a member of the Ankyrin family, which functions to provide cellular stability by anchoring the cytoskeleton to the plasma membrane...
  61. . Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011;43:969-76 pubmed publisher
    ..0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)).
  62. Santuccione A, Merlini M, Shetty A, Tackenberg C, Bali J, Ferretti M, et al. Active vaccination with ankyrin G reduces ?-amyloid pathology in APP transgenic mice. Mol Psychiatry. 2013;18:358-68 pubmed publisher
    ..proteins, we found in AD patients high serum levels of antibodies against the neuronal cytoskeletal protein ankyrin G (ankG); these correlated with slower rates of cognitive decline...
  63. He M, Jenkins P, Bennett V. Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. J Biol Chem. 2012;287:43995-4005 pubmed publisher
  64. Kapfhamer D, Miller D, Lambert S, Bennett V, Glover T, Burmeister M. Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. Genomics. 1995;27:189-91 pubmed
    ..We have localized ANK3 to human Chromosome 10q21 by fluorescence in situ hybridization...
  65. Wang J, Robinson J, O Neil C, Edwards J, Williams C, Huff M, et al. Ankyrin G overexpression in Hutchinson-Gilford progeria syndrome fibroblasts identified through biological filtering of expression profiles. J Hum Genet. 2006;51:934-42 pubmed
    ..amplification, Western analysis and immunofluorescence microscopy, all of which showed significantly increased ankyrin G expression...
  66. Maiweilidan Y, Klauza I, Kordeli E. Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C. Exp Cell Res. 2011;317:724-36 pubmed publisher
    ..In striated muscle, tissue-dependent alternative splicing generates unique Ank3 gene products (ankyrins-G); they share the Obscurin/Titin-Binding-related Domain (OTBD), a muscle-specific insert ..
  67. Hatzimanolis A, Smyrnis N, Avramopoulos D, Stefanis C, Evdokimidis I, Stefanis N. Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population. Psychiatr Genet. 2012;22:210-3 pubmed publisher
    Independent genome-wide association studies have implicated a common single nucleotide polymorphism within the ANK3 gene (rs10994336) in bipolar disorder (BD) susceptibility, thus establishing rs10994336 marker as a strong candidate ..
  68. Wirgenes K, Tesli M, Inderhaug E, Athanasiu L, Agartz I, Melle I, et al. ANK3 gene expression in bipolar disorder and schizophrenia. Br J Psychiatry. 2014;205:244-5 pubmed publisher
    b>ANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the relevance of its encoded protein, ankyrin-3, in these disorders remains elusive...
  69. Hughes T, Hansson L, Sønderby I, Athanasiu L, Zuber V, Tesli M, et al. A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia. Biol Psychiatry. 2016;80:323-30 pubmed publisher
    Ankyrin-3 (ANK3) was one of the first genes to reach significance in a bipolar disorder genome-wide association study. Many subsequent association studies confirmed this finding and implicated this gene in schizophrenia...
  70. Zhu S, Cordner Z, Xiong J, Chiu C, Artola A, Zuo Y, et al. Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder. Proc Natl Acad Sci U S A. 2017;114:10479-10484 pubmed publisher
    Genome-wide association studies have implicated the ANK3 locus in bipolar disorder, a major human psychotic illness. ANK3 encodes ankyrin-G, which organizes the neuronal axon initial segment (AIS)...
  71. Fabbri C, Corponi F, Albani D, Raimondi I, Forloni G, Schruers K, et al. Pleiotropic genes in psychiatry: Calcium channels and the stress-related FKBP5 gene in antidepressant resistance. Prog Neuropsychopharmacol Biol Psychiatry. 2018;81:203-210 pubmed publisher
    ..with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5)...
  72. Lischka K, Ladel S, Luksch H, Weigel S. Expression patterns of ion channels and structural proteins in a multimodal cell type of the avian optic tectum. J Comp Neurol. 2017;: pubmed publisher
    ..We present immunohistochemical data of structural proteins (NF200, Ankyrin G, and Myelin) and ion channels (Pan-Nav , Nav 1.6, and Kv 3.1b)...
  73. Dou X, Menkari C, Mitsuyama R, Foroud T, Wetherill L, Hammond P, et al. L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis. FASEB J. 2018;32:1364-1374 pubmed publisher
    ..Chen, X., Chen, S.-Y., Charness, M. E., Collaborative Initiative on Fetal Alcohol Spectrum Disorders. L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis. ..
  74. Komada M, Soriano P. [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J Cell Biol. 2002;156:337-48 pubmed
    ..These results indicate that betaIV-spectrin and ankyrin-G mutually stabilize the membrane protein cluster and the linked membrane cytoskeleton at AIS and NR. ..
  75. Devaux J, Alcaraz G, Grinspan J, Bennett V, Joho R, Crest M, et al. Kv3.1b is a novel component of CNS nodes. J Neurosci. 2003;23:4509-18 pubmed
    ..1b and Na+ channels are observed even in regions devoid of oligodendrocytes. Ankyrin G coimmunoprecipitates Kv3.1b in vivo, indicating that these two proteins may interact in the CNS at nodes...
  76. Logue M, Solovieff N, Leussis M, Wolf E, Melista E, Baldwin C, et al. The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity. Psychoneuroendocrinology. 2013;38:2249-57 pubmed publisher
    The ankyrin 3 gene (ANK3) produces the ankyrin G protein that plays an integral role in regulating neuronal activity. Previous studies have linked ANK3 to bipolar disorder and schizophrenia...
  77. Chouraki V, De Bruijn R, Chapuis J, Bis J, Reitz C, Schraen S, et al. A genome-wide association meta-analysis of plasma A? peptides concentrations in the elderly. Mol Psychiatry. 2014;19:1326-35 pubmed publisher
    ..In conclusion, our study results suggest that plasma A? peptides levels are valid endophenotypes in GWASs and can be used to characterize the metabolism and functions of APP and its metabolites. ..
  78. Guo X, Zhang Y, Du J, Yang H, Ma Y, Li J, et al. Association analysis of ANK3 gene variants with schizophrenia in a northern Chinese Han population. Oncotarget. 2016;7:85888-85894 pubmed publisher
    ..of 499 schizophrenia patients and 500 controls to investigate the effect of variant genotypes of 13 SNPs in ANK3 on schizophrenia risk...
  79. Lopez A, Wang X, Xu M, Maheshwari A, Curry D, Lam S, et al. Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. Mol Psychiatry. 2017;22:1464-1472 pubmed publisher
    b>ANK3, encoding the adaptor protein Ankyrin-G (AnkG), has been implicated in bipolar disorder by genome-wide association studies...
  80. Gottschalk M, Leussis M, Ruland T, Gjeluci K, Petryshen T, Bahn S. Lithium reverses behavioral and axonal transport-related changes associated with ANK3 bipolar disorder gene disruption. Eur Neuropsychopharmacol. 2017;27:274-288 pubmed publisher
    b>Ankyrin 3 (ANK3) has been implicated as a genetic risk factor for bipolar disorder (BD), however the resulting pathophysiological and treatment implications remain elusive...
  81. Roby Y. ANK3 gene polymorphisms and bipolar disorder: a meta-analysis. Psychiatr Genet. 2017;27:225-235 pubmed publisher
    Converging evidence has suggested ankyrin 3 (ANK3) as a risk gene for bipolar disorder (BD). However, association studies investigating its genetic variants and BD susceptibility have reported inconsistent results...
  82. Kretschmer T, Nguyen D, Beuerman R, Happel L, England J, Tiel R, et al. Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. J Neurosurg. 2002;97:1424-31 pubmed
    ..Overexpression of Na+ channels leads to hyperexcitability and painful phenomena. Ankyrin G, a multifunctional transmembrane protein of the axolemma, might be a key protein in neuroma formation because it ..
  83. Weimer J, Chattopadhyay S, Custer A, Pearce D. Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1. Biochem Biophys Res Commun. 2005;330:1176-81 pubmed
    ..Here we show a novel interaction between Hook1 and Ankyrin G, an adaptor protein that binds the spectrin-actin cytoskeleton and targets proteins to the peripheral membrane...
  84. Glinsky G, Berezovska O, Glinskii A. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest. 2005;115:1503-21 pubmed
  85. Ignatiuk A, Quickfall J, Hawrysh A, Chamberlain M, Anderson D. The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation. J Biol Chem. 2006;281:5956-64 pubmed
    ..In this report, we describe a new phosphotyrosine-independent p85 SH2-binding protein, ankyrin 3 (Ank3)...
  86. Dima D, Jogia J, Collier D, Vassos E, Burdick K, Frangou S. Independent modulation of engagement and connectivity of the facial network during affect processing by CACNA1C and ANK3 risk genes for bipolar disorder. JAMA Psychiatry. 2013;70:1303-11 pubmed publisher
    Genome-wide association studies (GWASs) indicate that single-nucleotide polymorphisms in the CACNA1C and ANK3 genes increase the risk for bipolar disorder (BD)...
  87. Hayashi A, Le Gal K, Södersten K, Vizlin Hodzic D, Ågren H, Funa K. Calcium-dependent intracellular signal pathways in primary cultured adipocytes and ANK3 gene variation in patients with bipolar disorder and healthy controls. Mol Psychiatry. 2015;20:931-40 pubmed publisher
    ..analyses of contingency tables for 80 categorical SNP results versus diagnoses showed a significant link with the ANK3 gene (rs10761482; likelihood ratio χ(2)=4.63; P=0.031)...
  88. Delvecchio G, Dima D, Frangou S. The effect of ANK3 bipolar-risk polymorphisms on the working memory circuitry differs between loci and according to risk-status for bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2015;168B:188-96 pubmed publisher
    Polymorphisms at the rs10994336 and rs9804190 loci of the Ankyrin 3 (ANK3) gene have been strongly associated with increased risk for bipolar disorder (BD)...
  89. Zhao W, Zhang Q, Yu P, Zhang Z, Chen X, Gu H, et al. The ANK3 gene and facial affect processing: An ERP study. Am J Med Genet B Neuropsychiatr Genet. 2016;171:861-6 pubmed publisher
    b>ANK3 is one of the most promising candidate genes for bipolar disorder (BD). A polymorphism (rs10994336) within the ANK3 gene has been associated with BD in at least three genome-wide association studies of BD [McGuffin et al...
  90. Sohn P, Tracy T, Son H, Zhou Y, Leite R, Miller B, et al. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016;11:47 pubmed publisher
    ..AIS cytoskeletal proteins, including ankyrin G and ?IV-spectrin, were downregulated in AD brains and negatively correlated with an increase in tau acetylated ..
  91. Zhang C, Cai J, Zhang J, Li Z, Guo Z, Zhang X, et al. Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2014;50:110-5 pubmed publisher
    ..Genetic variation in ankyrin 3 gene (ANK3) is likely to have widespread cognitive effects...
  92. Genetet S, Ripoche P, Le Van Kim C, Colin Y, Lopez C. Evidence of a structural and functional ammonium transporter RhBG·anion exchanger 1·ankyrin-G complex in kidney epithelial cells. J Biol Chem. 2015;290:6925-36 pubmed publisher
    ..This renal complex could participate in the regulation of acid-base homeostasis. ..