ANGPTL1

Summary

Gene Symbol: ANGPTL1
Description: angiopoietin like 1
Alias: ANG3, ANGPT3, ARP1, AngY, UNQ162, dJ595C2.2, angiopoietin-related protein 1, ANG-3, angioarrestin, angiopoietin 3, angiopoietin Y1, angiopoietin-like protein 1, dJ595C2.2 (angiopoietin Y1)
Species: human
Products:     ANGPTL1

Top Publications

  1. Perez Cuesta U, Aparicio Fernandez L, Guruceaga X, Martin Souto L, Abad Díaz de Cerio A, Antoran A, et al. Melanin and pyomelanin in Aspergillus fumigatus: from its genetics to host interaction. Int Microbiol. 2019;: pubmed publisher
    ..The DHN-melanin pathway is encoded in a cluster that includes six genes (abr1, abr2, ayg1, arp1, arp2, and pksP/alb1 genes) whose encoded proteins seem to be the origin of the pigment in endosomes...
  2. Fan H, Huang L, Zhuang X, Ai F, Sun W. Angiopoietin-like protein 1 inhibits epithelial to mesenchymal transition in colorectal cancer cells via suppress Slug expression. Cytotechnology. 2019;71:35-44 pubmed publisher
    The role of ANGPTL1 in cancer development is still little known, especially in colorectal cancer (CRC)...
  3. Zhang J, Qiu R, Xiang X. The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly. Sci Rep. 2018;8:11419 pubmed publisher
    ..The backbone of the vertebrate dynactin complex is the Arp1 (actin-related protein 1) mini-filament whose barbed end binds to the heterodimeric actin capping protein...
  4. Fujita I, Yamashita A, Yamamoto M. Dynactin and Num1 cooperate to establish the cortical anchoring of cytoplasmic dynein in S. pombe. J Cell Sci. 2015;128:1555-67 pubmed publisher
    ..Here, we identified three subunits of dynactin in fission yeast: Arp1, Mug5 and Jnm1 (also known as Mug1)...
  5. Urnavicius L, Zhang K, Diamant A, Motz C, Schlager M, Yu M, et al. The structure of the dynactin complex and its interaction with dynein. Science. 2015;347:1441-1446 pubmed publisher
    ..reconstruction reveals how dynactin is built around a filament containing eight copies of the actin-related protein Arp1 and one of β-actin...
  6. Bang S, Park S, Kim Y, Choi Y, Kim J. The activities of four constitutively expressed promoters in single-copy transgenic rice plants for two homozygous generations. Planta. 2015;241:1529-41 pubmed publisher
    We have characterized four novel constitutive promoters ARP1, H3F3, HSP and H2BF3 that are active in all tissues/stages of transgenic plants and stable over two homozygous generations...
  7. Lin M, Price E, Boatman S, Hagedorn E, Trompouki E, Satishchandran S, et al. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. elife. 2015;4: pubmed publisher
    ..b>Angptl1/2 are required for definitive hematopoiesis and vascular specification of the hemogenic endothelium...
  8. Sato R, Yamasaki M, Hirai K, Matsubara T, Nomura T, Sato F, et al. Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells. Oncol Rep. 2015;33:58-66 pubmed publisher
    Angiopoietin-like proteins (ANGPTLs), which comprise 7 members (ANGPTL1-ANGPTL7), structurally resemble angiopoietins...
  9. Eckley D, Schroer T. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Mol Biol Cell. 2003;14:2645-54 pubmed
    ..The cargo-binding domain contains a short, actin-like filament of the actin-related protein Arp1, a second actin-related protein, Arp11, and conventional actin...

More Information

Publications37

  1. Maffey L, Vega C, Parreño V, Garaicoechea L. Controlling Rotavirus-associated diarrhea: Could single-domain antibody fragments make the difference?. Rev Argent Microbiol. 2015;47:368-79 pubmed publisher
    ..Two sets of anti-RVA VHHs have been developed: ARP1-ARP3; 2KD1-3B2...
  2. Valiante V, Baldin C, Hortschansky P, Jain R, Thywißen A, Straßburger M, et al. The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors. Mol Microbiol. 2016;102:321-335 pubmed publisher
    ..cross-species promoter analysis identified specific DNA binding sites in the DHN-melanin biosynthesis genes pksP-arp1 intergenic region that can be recognized by bHLH and MADS-box transcriptional regulators...
  3. Yuki Y, Kurokawa S, Kozuka Hata H, Tokuhara D, Mejima M, Kuroda M, et al. Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. Regul Toxicol Pharmacol. 2016;76:128-36 pubmed publisher
    ..rotavirus infection, we previously produced a recombinant fragment of llama heavy-chain antibody to rotavirus (ARP1) in rice seeds (MucoRice-ARP1)...
  4. Chen H, Kuo T, Tseng C, Ma J, Yang S, Yen C, et al. Angiopoietin-like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma. Hepatology. 2016;64:1637-1651 pubmed publisher
    Angiopoietin-like protein 1 (ANGPTL1) has been shown to act as a tumor suppressor by inhibiting angiogenesis, cancer invasion, and metastasis...
  5. Udhane S, Flück C. Regulation of human (adrenal) androgen biosynthesis-New insights from novel throughput technology studies. Biochem Pharmacol. 2016;102:20-33 pubmed publisher
    ..Kinase p38α (MAPK14) was found to phosphorylate CYP17 for enhanced 17,20 lyase activity and RARB and ANGPTL1 were detected in novel networks regulating androgens...
  6. Costa R, Cardoso J, Power D. Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration. BMC Evol Biol. 2017;17:14 pubmed publisher
    ..Homologues of human ANGPTL1-7 were identified in fish, although ANGPTL8 was absent and a totally new family member designated angptl9 was ..
  7. Álvarez B, Krogh Andersen K, Tellgren Roth C, Martínez N, Günaydın G, Lin Y, et al. An Exopolysaccharide-Deficient Mutant of Lactobacillus rhamnosus GG Efficiently Displays a Protective Llama Antibody Fragment against Rotavirus on Its Surface. Appl Environ Microbiol. 2015;81:5784-93 pubmed publisher
    ..Lactobacillus rhamnosus GG to produce and display a VHH antibody fragment (referred to as anti-rotavirus protein 1 [ARP1]) on the surface was investigated. L...
  8. Aumeier C, Polinski E, Menzel D. Actin, actin-related proteins and profilin in diatoms: a comparative genomic analysis. Mar Genomics. 2015;23:133-42 pubmed publisher
    ..Among these are the highly conserved cytoplasmic Arp1 protein and the nuclear Arp4 as well as Arp6...
  9. Oliner J, Min H, Leal J, Yu D, Rao S, You E, et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell. 2004;6:507-16 pubmed
    ..These results imply that specific Ang2 inhibition may represent an effective antiangiogenic strategy for treating patients with solid tumors. ..
  10. Valenzuela D, Griffiths J, Rojas J, Aldrich T, Jones P, Zhou H, et al. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci U S A. 1999;96:1904-9 pubmed
    ..Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist. ..
  11. Chen H, Xiao Q, Hu Y, Chen L, Jiang K, Tang Y, et al. ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138. J Exp Clin Cancer Res. 2017;36:78 pubmed publisher
    Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate...
  12. Dabbah M, Attar Schneider O, Zismanov V, Tartakover Matalon S, Lishner M, Drucker L. Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation. J Leukoc Biol. 2016;100:761-770 pubmed
    ..Normal donor mesenchymal stem cells were cocultured with multiple myeloma cell lines (U266, ARP1) (multiple myeloma-conditioned mesenchymal stem cells) (1...
  13. Post S, Peeters W, Busser E, Lamers D, Sluijter J, Goumans M, et al. Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density. J Vasc Res. 2008;45:244-50 pubmed publisher
    ..Plaque Ang-2 levels are associated with MMP-2 activity. Ang-2-induced MMP-2 activity might play a role in the development of (unstable) plaque microvessels. ..
  14. Udhane S, Pandey A, Hofer G, Mullis P, Flück C. Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis. Sci Rep. 2015;5:10132 pubmed publisher
    ..genes; HSD3B2, HSD3B1, CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, DUSP10 and FREM2 are involved in signal transduction...
  15. Kuo T, Tan C, Chang Y, Hong C, Lee W, Chen M, et al. Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility. J Clin Invest. 2013;123:1082-95 pubmed publisher
    Angiopoietin-like protein 1 (ANGPTL1) is a potent regulator of angiogenesis. Growing evidence suggests that ANGPTL family proteins not only target endothelial cells but also affect tumor cell behavior...
  16. Di Carlo C, Bonifacio M, Tommaselli G, Bifulco G, Guerra G, Nappi C. Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium. Fertil Steril. 2009;91:2315-23 pubmed publisher
    ..Whether these local factors may induce, promote, and/or regulate this transformation remains to be determined. ..
  17. Dhanabal M, Jeffers M, Larochelle W, Lichenstein H. Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. Biochem Biophys Res Commun. 2005;333:308-15 pubmed
    ..angiopoietins and related family members, with particular emphasis on a recently identified protein known as angioarrestin. Our investigations clearly demonstrate that angioarrestin is an anti-angiogenic molecule...
  18. Lee H, Cho C, Hwang S, Choi H, Kim K, Ahn S, et al. Biological characterization of angiopoietin-3 and angiopoietin-4. FASEB J. 2004;18:1200-8 pubmed
    The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all of which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human) are interspecies orthologs...
  19. Kim I, Moon S, Koh K, Kim H, Uhm C, Kwak H, et al. Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. J Biol Chem. 1999;274:26523-8 pubmed
    ..Recombinant ARP2 protein induces sprouting in vascular endothelial cells but does not bind to the Tie1 or Tie2 receptor. These results suggest that ARP2 may exert a function on endothelial cells through autocrine or paracrine action. ..
  20. Lemmens I, Merregaert J, Van de Ven W, Kas K, Zhang C, Giraud S, et al. Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. Genomics. 1997;44:94-100 pubmed
    ..middle group (PYGM, ZFM1, SCG1, SCG2 (which proved to be the MEN1 gene), and PPP2R5B), and a telomeric group (H4B, ANG3, ANG2, ANG1, FON, FAU, NOF, NON, and D11S2196E) were observed...
  21. Liu Z, Liu C, Hao C, Xue Q, Huang X, Zhang N, et al. Aberrant expression of angiopoietin-like proteins 1 and 2 in cumulus cells is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome. Gynecol Endocrinol. 2016;32:557-61 pubmed publisher
    ..Emerging evidence demonstrates that angiopoietin-like protein 1 (ANGPTL1) and angiopoietin-like protein 2 (ANGPTL2) have an important influence on angiogenesis, androgen biosynthesis, ..
  22. Nieuwburg R, Nashchekin D, Jakobs M, Carter A, Khuc Trong P, Goldstein R, et al. Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte. elife. 2017;6: pubmed publisher
    ..A missense mutation in the dynactin Arp1 subunit causes most oskar mRNA to localise in the posterior cytoplasm rather than cortically...
  23. Avram D, Ishmael J, Nevrivy D, Peterson V, Lee S, Dowell P, et al. Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. J Biol Chem. 1999;274:14331-6 pubmed
    ..factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription...
  24. Kim I, Kwak H, Ahn J, So J, Liu M, Koh K, et al. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. FEBS Lett. 1999;443:353-6 pubmed
    ..amino acids) of the angiopoietin (Ang) family from human adult heart cDNA and have designated it angiopoietin-3 (Ang3)...
  25. Abdulmalek K, Ashur F, Ezer N, Ye F, Magder S, Hussain S. Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats. Am J Physiol Lung Cell Mol Physiol. 2001;281:L582-90 pubmed
    ..Induction of angiopoietin-3 in the kidney and diaphragm of hypoxic rats could be mediated through the HIF-1 transcription factor...
  26. Zeng L, Dai J, Ying K, Zhao E, Jin W, Ye Y, et al. Identification of a novel human angiopoietin-like gene expressed mainly in heart. J Hum Genet. 2003;48:159-62 pubmed
    ..The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart. ..
  27. Smagur A, Szary J, Szala S. Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours. Acta Biochim Pol. 2005;52:875-9 pubmed
    b>Angioarrestin is a recently described anti-angiogenic protein whose expression is down-regulated in solid tumours of various origins. It has a sequence identical to angiopoietin related protein-1...
  28. Yan Q, Jiang L, Liu M, Yu D, Zhang Y, Fang S, et al. ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling. Cancer Res. 2017;77:5831-5845 pubmed publisher
    ..Here, we report that downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC...