ANGPT1

Summary

Gene Symbol: ANGPT1
Description: angiopoietin 1
Alias: AGP1, AGPT, ANG1, ANG-1, angiopoietin-1
Species: human

Top Publications

  1. ncbi Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2
    Kyung Tae Kim
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
    J Biol Chem 280:20126-31. 2005
  2. ncbi Systemic analysis of tyrosine phosphorylated proteins in angiopoietin-1 induced signaling pathway of endothelial cells
    Young Mee Kim
    Center for Cell Signaling and Drug Discovery Research, College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Proteome Res 6:3278-90. 2007
  3. ncbi Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    S Davis
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1161-9. 1996
  4. ncbi Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
    Shigetomo Fukuhara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Nat Cell Biol 10:513-26. 2008
  5. ncbi Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium
    Hai Tao Yuan
    Molecular and Vascular Medicine, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:2011-22. 2009
  6. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
  7. ncbi Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors
    Oliver Stoeltzing
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:3370-7. 2003
  8. ncbi An autocrine linkage between matrix metalloproteinase-14 and Tie-2 via ectodomain shedding modulates angiopoietin-1-dependent function in endothelial cells
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 30:818-26. 2010
  9. ncbi Functional significance of Tie2 signaling in the adult vasculature
    Kevin G Peters
    Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, Ohio 45140, USA
    Recent Prog Horm Res 59:51-71. 2004
  10. ncbi Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2
    Marie B Marron
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Bld, P O Box 65, Leicester, LE2 7LX United Kingdom
    J Biol Chem 282:30509-17. 2007

Research Grants

  1. Targeting survival factors for ocular neovascularization
    Peter Campochiaro; Fiscal Year: 2009
  2. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2007
  3. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2009
  4. Angiopoietins in airway vascular leak and angiogenesis
    Donald M McDonald; Fiscal Year: 2010
  5. Tie2 Regulation and Role in Pathological Angiogenesis
    CLARENCE FINDLEY; Fiscal Year: 2007
  6. The Angiopoietins in Vascular Maintenance and Remodeling
    Christopher Kontos; Fiscal Year: 2005
  7. The Role of Tie2 and the Angiopoietins in EPC Biology
    GREGORY LAM; Fiscal Year: 2006
  8. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2005
  9. TIE2-Associated Molecular Targets in Tumor Vasculature
    DANIEL KENAN; Fiscal Year: 2003
  10. Regulation of Angiogenesis During Wound Healing
    Eric Howard; Fiscal Year: 2005

Detail Information

Publications176 found, 100 shown here

  1. ncbi Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2
    Kyung Tae Kim
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
    J Biol Chem 280:20126-31. 2005
    Angiopoietin-1 (Ang1) is an essential molecule for blood vessel formation; however, little is known about the structure-function relationships of Ang1 with its receptor, Tie2 (tyrosine kinase with immunoglobulin and epidermal growth ..
  2. ncbi Systemic analysis of tyrosine phosphorylated proteins in angiopoietin-1 induced signaling pathway of endothelial cells
    Young Mee Kim
    Center for Cell Signaling and Drug Discovery Research, College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Proteome Res 6:3278-90. 2007
    ..Angiopoietin-1 (Ang1) regulates angiogenesis as a ligand of Tie 2 receptor tyrosine kinase...
  3. ncbi Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    S Davis
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1161-9. 1996
    ..However, its expression in close proximity with developing blood vessels implicates Angiopoietin-1 in endothelial developmental processes...
  4. ncbi Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
    Shigetomo Fukuhara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Nat Cell Biol 10:513-26. 2008
    Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1)...
  5. ncbi Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium
    Hai Tao Yuan
    Molecular and Vascular Medicine, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:2011-22. 2009
    Angiopoietin 2 (Ang2) was originally shown to be a competitive antagonist for Ang1 of the receptor tyrosine kinase Tie2 in endothelial cells (ECs). Since then, reports have conflicted on whether Ang2 is an agonist or antagonist of Tie2...
  6. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
    ..Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme...
  7. ncbi Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors
    Oliver Stoeltzing
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:3370-7. 2003
    ..Thus, Ang-1 could potentially serve as an antineoplastic or anti-permeability agent for patients with metastatic colorectal cancer...
  8. ncbi An autocrine linkage between matrix metalloproteinase-14 and Tie-2 via ectodomain shedding modulates angiopoietin-1-dependent function in endothelial cells
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 30:818-26. 2010
    ..The angiopoietin (Ang)-Tie-2 system plays a critical role during fetal and adult angiogenesis. Herein, we explored the Tie-2 shedding-related molecular mechanisms and the pathophysiological significance...
  9. ncbi Functional significance of Tie2 signaling in the adult vasculature
    Kevin G Peters
    Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, Ohio 45140, USA
    Recent Prog Horm Res 59:51-71. 2004
    ..Tie2 extracellular domain (ExTek) was designed that blocked the activation of Tie2 by its activating ligand, angiopoietin 1 (Ang1)...
  10. ncbi Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2
    Marie B Marron
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Bld, P O Box 65, Leicester, LE2 7LX United Kingdom
    J Biol Chem 282:30509-17. 2007
    ..and generation of phosphorylated receptor fragments in the presence of cartilage oligomeric protein angiopoietin 1. A key function of gamma-secretase is in preventing accumulation of these phosphorylated fragments...
  11. ncbi Biological characterization of angiopoietin-3 and angiopoietin-4
    Hyuek Jong Lee
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    FASEB J 18:1200-8. 2004
    The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all of which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human) are interspecies orthologs...
  12. ncbi Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1
    Shirley H J Mei
    The Terrence Donnelly Research Laboratories, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    PLoS Med 4:e269. 2007
    ..We hypothesized that mesenchymal stem cells (MSCs), with or without transfection with the vasculoprotective gene angiopoietin 1 (ANGPT1) would have beneficial effects in experimental ALI in mice.
  13. ncbi Primary monocytes regulate endothelial cell survival through secretion of angiopoietin-1 and activation of endothelial Tie2
    Shai Y Schubert
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arterioscler Thromb Vasc Biol 31:870-5. 2011
    ..Tie2 plays a key role in endothelial health and vascular remodeling. We studied monocyte-mediated Tie2/angiopoietin signaling following interaction of primary monocytes with endothelial cells and its role in endothelial cell survival...
  14. ncbi Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
    Jonathan Oliner
    Amgen, Thousand Oaks, California 91320, USA
    Cancer Cell 6:507-16. 2004
    ..These results imply that specific Ang2 inhibition may represent an effective antiangiogenic strategy for treating patients with solid tumors...
  15. ncbi Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses
    Caroline Lemieux
    Research Center, Montreal Heart Institute, Montreal, QC, Canada H1T 1C8
    Blood 105:1523-30. 2005
    Angiopoietin-1 (Ang1) and -2 (Ang2) are endothelial growth factors that bind to the tyrosine kinase receptor Tie2 and contribute to orchestrate blood vessel formation during angiogenesis...
  16. ncbi Regulation of angiopoietin expression by bacterial lipopolysaccharide
    Mahroo Mofarrahi
    Critical Care Division, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    Am J Physiol Lung Cell Mol Physiol 294:L955-63. 2008
    ....
  17. ncbi Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, 79106 Freiburg, Germany
    J Biol Chem 278:1721-7. 2003
    ....
  18. ncbi Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells
    Tomoaki Murakami
    Department of Ophthalmology and Visual Sciences Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 280:31841-9. 2005
    ..We reported here the role of angiopoietin-1 (Ang1), which is a prosurvival factor in endothelial cells, during endothelial cell damage induced by oxidative stress...
  19. ncbi Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma
    Takuji Torimura
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka 830 0011, Japan
    J Hepatol 40:799-807. 2004
    ..Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC...
  20. ncbi Angiopoietin-1 promotes lymphatic sprouting and hyperplasia
    Tuomas Tammela
    Molecular Cancer Biology Laboratory, Ludwig Institute for Cancer Research, Biomedicum Helsinki, Finland
    Blood 105:4642-8. 2005
    b>Angiopoietin 1 (Ang1), a ligand for the receptor tyrosine kinase Tie2, regulates the formation and stabilization of the blood vessel network during embryogenesis...
  21. ncbi Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    J Am Soc Nephrol 15:566-74. 2004
    ..Podocytes produce endothelial factors, including angiopoietin 1 (ang1), and vascular endothelial growth factor (VEGF), whereas GEnC express their respective receptors Tie2 ..
  22. ncbi The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta
    Y Seval
    Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
    Placenta 29:809-15. 2008
    ....
  23. ncbi Localization of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy
    B Schiessl
    School of Surgical and Reproductive Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Placenta 30:79-87. 2009
    ..These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy...
  24. ncbi Angiopoietin-1 is normally expressed by periendothelial cells
    S C Satchell
    Thromb Haemost 86:1597-8. 2001
  25. ncbi Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo
    Tadanori Mammoto
    Department of Medicine, Division of Interdisciplinary Medicine and Biotechnology and Center for Vascular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 282:23910-8. 2007
    ..These results provide mechanistic evidence that targeting the endothelium through Tie-2 may offer specific therapeutic strategies in life-threatening endotoxemic conditions such as sepsis and acute respiratory distress syndrome...
  26. ncbi Angiopoietin-1 is an apoptosis survival factor for endothelial cells
    H J Kwak
    National Creative Research Initiatives Center for Cardiac Regeneration and Institute of Cardiovascular Research, Chonbuk National University School of Medicine, Chonju, South Korea
    FEBS Lett 448:249-53. 1999
    We examined the effect of angiopoietin-1 (Ang1) on apoptosis in human umbilical vein endothelial cells (HUVECs). Ang1 (5-1000 ng/ml) dose-dependently inhibited apoptosis under a serum-deprived state...
  27. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
    Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2 receptor tyrosine kinase...
  28. ncbi Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity
    W N Procopio
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 274:30196-201. 1999
    ....
  29. ncbi Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2
    B Witzenbichler
    Department of Cardiovascular Research, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, Boston, MA 02135, USA
    J Biol Chem 273:18514-21. 1998
    ....
  30. ncbi Angiopoietin-1 induces sprouting angiogenesis in vitro
    T I Koblizek
    Department of Molecular Cell Biology Max Planck Institute for Physiological and Clinical Research Kerckhoff Institute Parkstrasse 1, 61231, Bad Nauheim, Germany
    Curr Biol 8:529-32. 1998
    ..Although 'knockouts' of the gene encoding the Tie2 receptor, or its activating ligand angiopoietin-1 (Ang1), result in embryonic lethality in mice due to an absence of remodeling and sprouting of blood vessels [4,5], ..
  31. ncbi Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development
    C Dunk
    Department of Reproductive and Vascular Biology, University of Birmingham, Birmingham Women s Hospital, United Kingdom
    Am J Pathol 156:2185-99. 2000
    ....
  32. ncbi Admission angiopoietin levels in children with septic shock
    John S Giuliano
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 28:650-654. 2007
    ..Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted...
  33. ncbi Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma
    Noboru Mitsuhashi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Japan
    Hepatology 37:1105-13. 2003
    ..In conclusion, an increased expression of Ang-2/1 in the presence of VEGF may play a critical role in promoting tumor angiogenesis and progression in human HCC...
  34. ncbi Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1
    Ilaria Cascone
    Department of Oncological Sciences, University of Torino, Candiolo, Italy
    Blood 102:2482-90. 2003
    ..Taken together, these results further expand our understanding of angiopoietin-1-mediated endothelial cell motility during vascular network assembly and angiogenesis...
  35. ncbi Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1
    S Tian
    Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington DC 20007, USA
    Br J Cancer 86:645-51. 2002
    ..These findings suggest that a vascular stabilization effect of angiopoietin-1 accounts for the inhibition of tumour growth...
  36. ncbi Angiopoietin-2 levels as a biomarker of cardiovascular risk in patients with hypertension
    Jeetesh V Patel
    University Department of Medicine, City Hospital, Birmingham, UK
    Ann Med 40:215-22. 2008
    ..We hypothesized that raised levels of angiopoietin (Ang)-1 and -2 would predict events in patients with hypertension treated for CVD...
  37. ncbi Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2
    Eli Geva
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0556, USA
    J Clin Endocrinol Metab 87:4213-24. 2002
    ..Quantitative real-time PCR analysis demonstrated that VEGF-A and Ang1 mRNA increased in a linear pattern by 2.5 (not significant) and 2.8%/wk (P = 0...
  38. ncbi Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
    T Asahara
    Department of Medicine Cardiology, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circ Res 83:233-40. 1998
    ..Addition of Ang 1 to VEGF (Ang1+VEGF) produced an increase in macroscopically evident perfusion of the corneal neovasculature ..
  39. ncbi Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, and Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan, ROC
    J Biomed Sci 11:163-71. 2004
    ..b>Ang1, Ang2, Tie1, and Tie2 were measured immediately after ligation of the coronary artery, and at 6 h, 1 and 3 days, ..
  40. ncbi Adipose tissue growth and regression are regulated by angiopoietin-1
    Susan M Dallabrida
    Division of Surgical Research, Children s Hospital, Boston, MA, USA
    Biochem Biophys Res Commun 311:563-71. 2003
    ..Obese mice injected with ang1/pcDNA had reduced rates of weight gain and fat pad weights, regardless of the route of plasmid administration (..
  41. ncbi Characterization of VEGF and angiopoietins expression in human corpus cavernosum during aging
    Nuno Tomada
    Department of Urology, Hospital de S Joao, and Faculty of Medicine of Universidade do Porto, Portugal
    J Sex Med 7:1410-8. 2010
    ..However, cellular and molecular changes involved in erectile pathophysiology in aging male remain to be elucidated...
  42. ncbi Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy
    Susan M Dallabrida
    Division of Vascular Biology, Children s Hospital, Boston, Massachusetts 02115, USA
    FASEB J 22:3010-23. 2008
    Angiopoietins were thought to be endothelial cell-specific via the tie2 receptor. We showed that angiopoietin-1 (ang1) also interacts with integrins on cardiac myocytes (CMs) to increase survival...
  43. ncbi Vascular development in the mouse embryonic pancreas and lung
    K L Colen
    Department of Surgery, New York University Medical Center, NY 10016, USA
    J Pediatr Surg 34:781-5. 1999
    ..the formation of blood vessels in the developing mouse pancreas and lung by studying two ligands, angiopoietin-1 (ang1) and angiopoietin-2 (ang2), which are thought to play a role as angiogenesis-activating factors in development...
  44. ncbi Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells
    Y Yu
    Surgical Research Laboratory, Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 159:2271-80. 2001
    ..In contrast, there was little expression of angiopoietin-1 (Ang1) or VEGF...
  45. ncbi Expressions of Angiopoietin-1, Angiopoietin-2, and Tie2 and their roles in rat renal allografts with chronic allograft nephropathy
    X Ma
    Transplantation Institute, West China Hospital, Sichuan University, Chengdu, China
    Transplant Proc 40:2795-9. 2008
    Angiopoietin-1 (Ang1) and -2(Ang2) are 2 ligands for the endothelium-specific tyrosine kinase Tie2...
  46. ncbi Rapamycin and cyclosporine have different effects on expression of Ang-1 and Ang-2 and Tie2 in rat renal allograft with chronic allograft nephropathy
    X Ma
    Transplantation Institute, West China Hospital, Sichuan University, Chengdu, China
    Transplant Proc 40:2804-7. 2008
    Previous studies have indicated that angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) and tyrosine kinase receptor Tie2 regulate the maintenance and integrity of blood vessels and have potential anti-inflammatory properties...
  47. ncbi Angiopoietin-1 alters tumor growth by stabilizing blood vessels or by promoting angiogenesis
    Naoyuki Satoh
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Cancer Sci 99:2373-9. 2008
    The maturation of blood vessels requires mural cell adhesion to endothelial cells. Angiopoietin-1 (Ang1), a ligand for Tie2 receptor expressed on endothelial cells, plays a critical role in cell adhesion between mural cells and ..
  48. ncbi COMP-Ang1, a chimeric form of Angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation
    Byung Chul Jeong
    Dental Science Research Institute, BK21 Project, School of Dentistry, Chonnam National University, Gwangju 500 757, Korea
    Bone 46:479-86. 2010
    Angiogenesis is closely associated with bone formation, especially endochondral ossification. Angiopoietin 1 (Ang1) is a specific growth factor functioning to generate a stable and matured vasculature through the Tie2 receptor/PI3K/AKT ..
  49. ncbi COMP-Ang1, angiopoietin-1 variant protects radiation-induced bone marrow damage in C57BL/6 mice
    Hae June Lee
    Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    J Radiat Res 49:313-20. 2008
    ..of the N-terminal portion of Ang1 with short coiled-coil domains of cartilage oligomeric matrix protein-Angiopoietin 1 (COMP-Ang1) which are, long enough for oligomerization but short enough to avoid problems of aggregation and ..
  50. ncbi Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathway
    Xian Bao Liu
    Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    Acta Pharmacol Sin 29:815-22. 2008
    The angiopoietin-1 (Ang1)/Tie-2 signaling system not only plays a pivotal role in vessel growth, remodeling, and maturation, but also reduces apoptosis of endothelial cells, neurons, and cardiomyocytes...
  51. ncbi Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes
    Sik Lee
    Department of Internal Medicine, Chonbuk National University Medical School, 634 18 Keum Am dong, Jeonju 561 712, Republic of Korea
    Nephrol Dial Transplant 22:396-408. 2007
    ..Angiopoietin-1 (Ang1) plays essential roles in regulating vascular growth, development, maturation, permeability and inflammation...
  52. ncbi High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1
    Harprit Singh
    University of Leicester, Department of Cardiovascular Sciences, RKCSB, PO Box 65, Leicester LE2 7LX, UK
    Microvasc Res 79:121-7. 2010
    ..Angiopoietin-1 (Ang1), a ligand for endothelial receptor, is a potent vascular protective factor important in maintaining normal ..
  53. ncbi Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells
    Huiping Gu
    Department of Cardiology, Peking University Third Hospital, Beijing 100191, China
    Biochem Biophys Res Commun 392:178-82. 2010
    Angiopoietin-1 (Ang1) is a ligand for the endothelial-specific tyrosine kinase receptor Tie2 and has been shown to play an essential role in embryonic vasculature development...
  54. ncbi Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak
    Z Master
    Division of Molecular and Cellular Biology, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Research Building, S Wing, Room 227, Toronto, Ontario, M4N 3M5, Canada
    EMBO J 20:5919-28. 2001
    ..Angiopoietin-1 (Ang1) can promote EC migration; however, the signaling mechanisms underlying this process remain elusive...
  55. ncbi Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1
    Shigetomo Fukuhara
    Department of Structural AnalysisNational Cardiovascular Center Research InstituteFujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Exp Mol Med 41:133-9. 2009
    Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels...
  56. ncbi Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells
    Nesreen S Ismail
    Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts, USA
    J Invest Dermatol 130:1307-17. 2010
    ..Thus, agents that counteract these damages may have therapeutic value. Herein, we show that angiopoietin-1 (ang1) prevented and blocked H(2)O(2)-induced increases in superoxides in human spontaneously immortalized keratinocyte ..
  57. ncbi Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway
    David Morrow
    Department of Surgery, University of Rochester Medical Center, Box SURG, 601 Elmwood Avenue, Rochester, NY 14642 8410, USA
    Cardiovasc Res 79:313-21. 2008
    ..Our aims were to determine the effect of alcohol (EtOH) on endothelial angiogenic activity and to delineate the cell signalling mechanisms involved...
  58. ncbi Expression and purification of recombinant human angiopoietin-1 produced in Chinese hamster ovary cells
    Su Jeong Hwang
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yuseong Gu, Daejon 305 701, South Korea
    In Vitro Cell Dev Biol Anim 43:162-7. 2007
    Angiopoietin-1 (Ang1) is an essential molecule for blood vessel formation...
  59. ncbi High-level expression and purification of a designed angiopoietin-1 chimeric protein, COMP-Ang1, produced in Chinese hamster ovary cells
    Su Jeong Hwang
    Department of Biological Sciences, KAIST, 373 1 Kusong Dong, Yuseong Gu, Daejon 305 701, Korea
    Protein J 27:319-26. 2008
    A designed angiopoietin-1 (Ang1) chimeric protein with nonleaky angiogenic activity, COMP-Ang1, is an effective alternative to native Ang1 for therapeutic angiogenesis in vivo...
  60. ncbi Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
    S Tanaka
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Clin Invest 103:341-5. 1999
    ..Angiopoietin-1 (Ang1) was equally expressed in HCC and adjacent noncarcinomatous liver tissue...
  61. ncbi Angiopoietin-2-driven vascular remodeling in airway inflammation
    Sebastien P Tabruyn
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0425, USA
    Am J Pathol 177:3233-43. 2010
    ..However, the precise contributions of both angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are not clear...
  62. ncbi The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus
    P Kümpers
    Department of Nephrology, Hanover Medical School, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    Ann Rheum Dis 68:1638-43. 2009
    ..Recently, the endothelial-specific Ang-Tie ligand-receptor system has been identified as a major regulator of vascular responsiveness to inflammatory stimuli...
  63. ncbi A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis
    Hak Zoo Kim
    National Research Laboratory for Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, 373 1, Guseong Dong, Daejeon, 305 701, Republic of Korea
    Biochim Biophys Acta 1793:772-80. 2009
    Despite that angiopoietin-2 (Ang2) produces more versatile and dynamic functions than angiopoietin-1 (Ang1) in angiogenesis and inflammation, the molecular mechanism that underlies this difference is still unknown...
  64. ncbi Adeno-associated virus vectors simultaneously encoding VEGF and angiopoietin-1 enhances neovascularization in ischemic rabbit hind-limbs
    Feng Chen
    Department of Vascular Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Acta Pharmacol Sin 28:493-502. 2007
    Angiopoietin-1 (Ang1) and vascular endothelial growth factor A (VEGF) play important roles in vascular formation and maturation, suggesting a combination of these 2 would be a promising therapy for ischemic diseases...
  65. ncbi In utero angiopoietin-2 gene delivery remodels placental blood vessel phenotype: a murine model for studying placental angiogenesis
    E Geva
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143 0556, USA
    Mol Hum Reprod 11:253-60. 2005
    Angiopoietin (Ang)-2, the natural antagonist of the Ang1/Tie2 receptor is a complex regulator of blood vessel plasticity that plays a pivotal role in both vessel sprouting [in the presence of vascular endothelial growth factor (VEGF)-A] ..
  66. ncbi Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage
    Gavin Thurston
    Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA
    J Anat 200:575-80. 2002
    ..To learn more about the effects of these factors in vivo, we have overexpressed VEGF-A or Angiopoietin-1 (Ang1) in two systems in mice, and examined the effects on blood vessel growth and function...
  67. ncbi Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    J Am Soc Nephrol 13:544-50. 2002
    ..b>Angiopoietin 1 (Ang1) acts via the endothelial receptor Tie2 to promote maturation and stabilization of blood vessels, ..
  68. ncbi Priming with angiopoietin-1 augments the vasculogenic potential of the peripheral blood stem cells mobilized with granulocyte colony-stimulating factor through a novel Tie2/Ets-1 pathway
    Min Seok Kim
    National Research Laboratory for Cardiovascular Stem Cell, Innovative Research Institute for Cell Therapy, Seoul National University Hospital, Seoul 110 744, Korea
    Circulation 120:2240-50. 2009
    ..priming peripheral blood stem cells enriched by granulocyte colony-stimulating factor mobilization and apheresis ((mob)PBSCs) with angiopoietin-1 (Ang1), to enhance the engraftment into the ischemic tissue and neovasculogenic potential.
  69. ncbi Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx
    Andrew H J Salmon
    Department of Physiology and Pharmacology, Preclinical Veterinary School, Microvascular Research Laboratories, Bristol Heart Institute, University of Bristol, Southwell Street, Bristol, UK
    Cardiovasc Res 83:24-33. 2009
    In this study, we wished to determine whether angiopoietin-1 (Ang1) modified the permeability coefficients of non-inflamed, intact continuous, and fenestrated microvessels in vivo and to elucidate the underlying cellular mechanisms.
  70. ncbi Protective role of angiopoietin-1 in endotoxic shock
    Bernhard Witzenbichler
    Department of Cardiology and Pneumology, Universitatsmedizin Berlin, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 111:97-105. 2005
    Angiopoietin-1 (Ang1) plays an essential role in embryonic vasculature development, protects the adult peripheral vasculature from leakage, and has antiinflammatory properties...
  71. ncbi Role of Src in angiopoietin 1-induced capillary morphogenesis of endothelial cells: Effect of chronic hypoxia on Src inhibition by PP2
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Cell Signal 19:472-80. 2007
    Signal transduction pathways leading to angiopoietin 1 (Ang1)-induced capillary morphogenesis by endothelial cells remain poorly defined...
  72. ncbi Use of NaCl prevents aggregation of recombinant COMP-angiopoietin-1 in Chinese hamster ovary cells
    Hye Kyung Ju
    Bio R and D Center, Genexel Sein, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
    J Biotechnol 143:145-50. 2009
    To investigate the effect of hyperosmotic medium on production and aggregation of the variant of Angiopoietin-1 (Ang1), cartilage oligomeric matrix protein (COMP)-Ang1, in recombinant Chinese hamster ovary (CHO) cells, CHO cells were ..
  73. ncbi Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice
    Z G Zhang
    Department of Neurology, Henry Ford Health Sciences Center, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Neuroscience 113:683-7. 2002
    Angiopoietin-1 (Ang1) is a ligand for the endothelial specific receptor tyrosine kinase, Tie2, that protects the adult peripheral vasculature from vascular leakage...
  74. ncbi Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane
    Merle Drenkhahn
    Institute of Physiology, Medical University of Luebeck, Luebeck, Germany
    Fertil Steril 81:869-75. 2004
    To investigate the role of angiopoietin 1 and 2 (ANGPT1/ANGPT2) in angiogenesis of the ectopic endometrium as a crucial step in the development of an endometriotic lesion, we analyzed their expression patterns in an experimental model of ..
  75. ncbi Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium
    Costantino Di Carlo
    Department of Obstetrics and Gynecology, University of Naples Federico II, Naples, Italy
    Fertil Steril 91:2315-23. 2009
    To evaluate the expression of vascular endothelial growth factor (VEGF), angiopoietin 1 and 2 (ANGPT1/ANGPT2), and matrix metalloproteinases 1, 2, and 9 (MMP-1, MMP-2, MMP-9) in eutopic and ectopic endometrium.
  76. ncbi Synergistic effect of angiopoietin-1 and vascular endothelial growth factor on neoangiogenesis in hypercholesterolemic rabbit model with acute hindlimb ischemia
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Taipei 111, Taiwan
    Life Sci 73:563-79. 2003
    Vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) are essential for vascular integrity and development...
  77. ncbi Localization of angiopoietin-1 and Tie2 immunoreactivity in rodent ependyma and adjacent blood vessels suggests functional relationships
    Brooke N Horton
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Histochem Cytochem 58:53-60. 2010
    Angiopoietin-1 (Angpt1; previously Ang-1) participates in vascular maintenance and remodeling. In the current study, we investigated the distribution of Angpt1 protein in rat brain...
  78. ncbi Coadministration of adenoviral vascular endothelial growth factor and angiopoietin-1 enhances vascularization and reduces ventricular remodeling in the infarcted myocardium of type 1 diabetic rats
    Samson Mathews Samuel
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut, USA
    Diabetes 59:51-60. 2010
    ..The present study evaluates the reversal of diabetes-mediated impairment of angiogenesis in the infarcted diabetic rat myocardium by proangiogenic gene therapy...
  79. ncbi COMP-Ang1 potentiates the antitumor activity of 5-fluorouracil by improving tissue perfusion in murine Lewis lung carcinoma
    Jeong Ah Hwang
    Department of Physiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon 301 131, Republic of Korea
    Mol Cancer Res 7:1920-7. 2009
    ..We report here that an angiopoietin-1 variant, COMP-Ang1, promotes vascular remodeling and pericyte coverage and thereby promotes the efficient delivery of a ..
  80. ncbi Changes in angiopoietin expression in glomeruli involved in glomerulosclerosis in rats with daunorubicin-induced nephrosis
    Yuan Hang Lu
    Department of Nephrology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Acta Pharmacol Sin 27:579-87. 2006
    ..To study the potential pathological role of endogenous angiopoietins in daunorubicin-induced progressive glomerulosclerosis in rats...
  81. ncbi COMP-Ang1, a variant of angiopoietin 1, inhibits serum-deprived apoptosis of mesenchymal cells via PI3K/Akt and mitogen-activated protein kinase pathways
    Kkot Nim Lee
    Dental Science Research Institute and the BK21 Project, School of Dentistry, Chonnam National University, Republic of Korea
    Pharmacology 86:327-35. 2010
    Cartilage oligomeric matrix protein (COMP)-angiopoietin 1 (Ang1) is a soluble and stable form of Ang1 which plays important roles in vessel formation and the survival of endothelial cells, neurons and cardiomyocytes...
  82. ncbi Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2
    Keisuke Sako
    Department of Structural Analysis, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Biol Chem 284:5592-601. 2009
    Angiopoietin-1 (Ang1) regulates both vascular quiescence and angiogenesis through the receptor tyrosine kinase Tie2...
  83. ncbi Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis
    Christopher S Milner
    University of Leicester, Department of Cardiovascular Sciences, RKCSB, PO Box 65, Leicester LE2 7LX, UK
    Microvasc Res 77:187-91. 2009
    Angiopoietin-1 (Ang1) has key roles in development and maintenance of the vascular system. The ligand is a potent inhibitor of vascular leakage and suppresses endothelial apoptosis and vessel regression...
  84. ncbi Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody
    Angela Coxon
    Department of Oncology Research, Amgen, Inc, Thousand Oaks, California 91320, USA
    Mol Cancer Ther 9:2641-51. 2010
    ..peptide-Fc fusion protein (peptibody) that inhibits angiogenesis by preventing the interaction of angiopoietin-1 (Ang1) and Ang2 with their receptor, Tie2...
  85. ncbi Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury
    So Ri Kim
    Department of Internal Medicine and Airway Remodeling Laboratory, Chonbuk National University Medical School, Jeonju, Korea
    Exp Mol Med 40:320-31. 2008
    ..Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage and also has beneficial effects in several ..
  86. ncbi Protective effect of COMP-angiopoietin-1 on cyclosporine-induced renal injury in mice
    Sik Lee
    Department of Internal Medicine, Chonbuk National University Medical School, 634 18, Keum Am Dong, Jeonju, 561 712, Korea
    Nephrol Dial Transplant 23:2784-94. 2008
    ..However, the limitation of CsA use is chronic nephrotoxicity. A soluble, stable and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1 has been developed...
  87. ncbi Blockade of airway inflammation and hyper-responsiveness by an angiopoietin-1 variant, COMP-Ang1
    Kyung Sun Lee
    Department of Internal Medicine, Airway Remodeling Laboratory, Chonbuk National University Medical School, JeonJu 561 180, Korea
    Exp Mol Med 39:733-45. 2007
    ..Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage...
  88. ncbi COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice
    Hoon Ki Sung
    Department of Biological Science, Korea Advanced Institute of Science and Technology, Biomedical Research Center, Daejeon, South Korea
    Am J Physiol Endocrinol Metab 297:E402-9. 2009
    ..glucose uptake in chow-fed and high-fat-fed mice injected with adenovirus containing modified angiopoietin-1, COMP-Ang1, via euglycemic-hyperinsulinemic clamp...
  89. ncbi Peritubular capillary preservation with COMP-angiopoietin-1 decreases ischemia-reperfusion-induced acute kidney injury
    Yu Jin Jung
    Renal Regeneration Laboratory and Dept of Internal Medicine, Chonbuk National Univ Medical School, 634 18 Keum Am dong, Jeonju 560 180, Korea
    Am J Physiol Renal Physiol 297:F952-60. 2009
    ..Cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) is a variant of native angiogenic factor angiopoietin-1 engineered to have higher activity...
  90. ncbi Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell-cell interactions requires activation of PKC beta
    Yihong Wang
    BIDMC Genomic Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Physiol 198:53-61. 2004
    Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) cooperate in migration and survival of endothelial cells by activation of phosphatidylinositol-3 (PI-3) kinase and mitogen activating protein (MAP) kinase pathways...
  91. ncbi Hydrogen peroxide produced by angiopoietin-1 mediates angiogenesis
    Young Mee Kim
    Centre for Cell Signaling Research, Division of Molecular Life Sciences and College of Pharmacy, Ewha Womans University, Seoul, Korea
    Cancer Res 66:6167-74. 2006
    Angiopoietin-1 (Ang1) mediates angiogenesis by enhancing endothelial cell survival and migration...
  92. ncbi Scaffolds with covalently immobilized VEGF and Angiopoietin-1 for vascularization of engineered tissues
    Loraine L Y Chiu
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St, Toronto, Ontario M5S 3E5, Canada
    Biomaterials 31:226-41. 2010
    ..We covalently immobilized vascular endothelial growth factor (VEGF) and Angiopoietin-1 (Ang1) onto three-dimensional porous collagen scaffolds using 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride ..
  93. ncbi Angiopoietin 1 and 2 gene and protein expression is differentially regulated in acute anti-Thy1.1 glomerulonephritis
    Valentina Campean
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 294:F1174-84. 2008
    ..We reasoned that other angiogenic factors are likewise involved in glomerular capillary remodeling and found angiopoietin 1 and -2 (ANG1 and ANG2) mRNA to be upregulated in cDNA microarrays of microdissected glomeruli of anti-Thy1...
  94. ncbi Expression and function of angiopoietin-1 in breast cancer
    A J Hayes
    Department of Oncology, Department of Biostatistics, Georgetown University Medical Center, 3970 Reservoir Road, NW RB E301, Washington, DC 20007, USA
    Br J Cancer 83:1154-60. 2000
    Angiopoietin-1 (Ang1) has been shown to act as an angiogenic promoter in embryonic angiogenesis by promoting vascular branching, pericyte recruitment and endothelial survival...
  95. ncbi Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases
    L Düring-Olsen
    Carlsberg Research Laboratory, Gamle Carlsberg Vej 10, DK 2500 Copenhagen Valby, Denmark
    Curr Genet 35:609-17. 1999
    ..Overexpression studies identified BAP2, BAP3, AGP1 and GNP1 as genes encoding transporters of cysteine...
  96. ncbi Expression of the vascular endothelial growth factor and angiopoietins in mucoepidermoid carcinoma of salivary gland
    Ana P D Demasi
    Departamento de Patologia Oral, Faculdade de Odontologia e Centro de Pesquisas São Leopoldo Mandic, Rua José Rocha Junqueira, 13, Campinas, SP, CEP 13045 755, Brazil
    Head Neck Pathol 6:10-5. 2012
    ..Our results indicate that the MEC environment favors cooperative activity between Angs and VEGF in modulating vascular growth and tumor aggressiveness...
  97. ncbi Genetic polymorphism in a VEGF-independent angiogenesis gene ANGPT1 and overall survival of colorectal cancer patients after surgical resection
    Jingyao Dai
    Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    PLoS ONE 7:e34758. 2012
    ..This study aimed to investigate the association between genetic variations in several major VEGF-independent signaling pathway genes and the overall survival of CRC patients...
  98. ncbi Osteogenic and angiogenic effects of mesenchymal stromal cells with co-transfected human Ang-1 gene and BMP2 gene
    Xudong Liu
    Department of Orthopaedic Surgery, Shanghai Sixth People s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, People s Republic of China
    Biotechnol Lett 33:1933-8. 2011
    ..These results demonstrate that the combined gene therapy with hAng-1 and hBMP2 using lentivirally co-transfected MSCs is feasible...
  99. ncbi Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome
    X Cui
    Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA
    Neuroscience 227:223-31. 2012
    ..Combination treatment also significantly increased the expression of Angiopoietin-1 (Ang1), Tie2 and Occludin in the IBZ (p<0.05, n=8/group)...
  100. ncbi Time-dependent changes of plasma concentrations of angiopoietins, vascular endothelial growth factor, and soluble forms of their receptors in nonsmall cell lung cancer patients following surgical resection
    Ewa Kopczynska
    Department of Pathobiochemistry and Clinical Chemistry, College of Medicine, Nicolaus Copernicus University, M Skłodowska Curie 9 Street, 85 094 Bydgoszcz, Poland
    ISRN Oncol 2012:638352. 2012
    ..The study group consisted of 37 patients with stage I nonsmall cell lung cancer. Plasma concentrations of Ang1, Ang2, sTie2, VEGF, and sVEGF R1 were evaluated by ELISA three times: before surgical resection and on ..
  101. ncbi Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation
    Xian Bao Liu
    Cardiovascular Key Lab of Zhejiang Province, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    J Zhejiang Univ Sci B 13:616-23. 2012
    ..The purpose of this study was to investigate the protective effect of angiopoietin-1 (Ang1) preconditioning on MSC survival and subsequent heart function improvement after transplantation.

Research Grants65

  1. Targeting survival factors for ocular neovascularization
    Peter Campochiaro; Fiscal Year: 2009
    ..Defining these survival signals is an important goal. Two candidates are angiopoietin 1 (Ang1) acting through the Tie receptors on endothelial cells and platelet-derived growth factor-B (PDGF-B) ..
  2. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2007
    ..Angiopoietin-1 (Ang1) activates Tie2 receptor phosphorylation, whereas Angiopoietin-2 (Ang2) inhibits Ang1 actions or activates Tie2 ..
  3. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2009
    ..Angiopoietin-1 (Ang1) activates Tie2 receptor phosphorylation, whereas Angiopoietin-2 (Ang2) inhibits Ang1 actions or activates Tie2 ..
  4. Angiopoietins in airway vascular leak and angiogenesis
    Donald M McDonald; Fiscal Year: 2010
    ..Angiopoietin-1 (Ang1) activates Tie2 receptor phosphorylation, whereas Angiopoietin-2 (Ang2) inhibits Ang1 actions or activates Tie2 ..
  5. Tie2 Regulation and Role in Pathological Angiogenesis
    CLARENCE FINDLEY; Fiscal Year: 2007
    ..Regulation of Tie2 signaling and function is complex, as its ligands, Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2), have opposing effects on the vasculature...
  6. The Angiopoietins in Vascular Maintenance and Remodeling
    Christopher Kontos; Fiscal Year: 2005
    ..Tie2 is unique among RTKs in that it has two ligands with apparently opposing actions. Angiopoietin-1 (Ang1) is an activating ligand while Angiopoietin-2 (Ang2) is thought to be a naturally occurring antagonist for Tie2...
  7. The Role of Tie2 and the Angiopoietins in EPC Biology
    GREGORY LAM; Fiscal Year: 2006
    ..We hypothesize that Tie2 is required for EPC-mediated vascular repair in atherosclerosis and that Ang2, but not Ang1, will enhance EPC repair of atherosclerotic lesions. The Specific Aims of this proposal are to: 1...
  8. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2005
    ..project will build on the discovery made during the first two and a half years of this grant that angiopoietin-1 (Ang1) reduces plasma leakage evoked by multiple different inflammatory mediators...
  9. TIE2-Associated Molecular Targets in Tumor Vasculature
    DANIEL KENAN; Fiscal Year: 2003
    ..The ligands for Tie2-Angiopoietin-1 (Ang1) and Ang2-each exhibit opposite effects on the vasculature...
  10. Regulation of Angiogenesis During Wound Healing
    Eric Howard; Fiscal Year: 2005
    ..endothelial cell-specific receptor tyrosine kinase, Tie2, when stimulated by its primary ligand, angiopoietin-1 (Ang1), promotes blood vessel stability by stimulating cell viability, basement membrane integrity, and perivascular cell ..
  11. Targeting survival factors for ocular neovascularization
    Peter Campochiaro; Fiscal Year: 2009
    ..Defining these survival signals is an important goal. Two candidates are angiopoietin 1 (Ang1) acting through the Tie receptors on endothelial cells and platelet-derived growth factor-B (PDGF-B) ..
  12. Targeting survival factors for ocular neovascularization
    Peter A Campochiaro; Fiscal Year: 2010
    ..Defining these survival signals is an important goal. Two candidates are angiopoietin 1 (Ang1) acting through the Tie receptors on endothelial cells and platelet-derived growth factor-B (PDGF-B) ..
  13. RESOLUTION OF GLOMERULOSCLEROSIS
    Agnes B Fogo; Fiscal Year: 2010
    ..VEGF-A and angiopoietin-1 (Ang1) are normally derived from the podocyte...
  14. RESOLUTION OF GLOMERULOSCLEROSIS
    Agnes Fogo; Fiscal Year: 2007
    ..VEGF-A and angiopoietin-1 (Ang1) are normally derived from the podocyte...
  15. RETINAL NEOVASCULARIZATION IN DIABETIC RETINOPATHY
    Peter Campochiaro; Fiscal Year: 2001
    ..We will also explore whether hypoxia-inducible factor-1 (HIF-1), Angiopoietin 1 (Ang1) or Ang2 play a role in the development of retinal neovascularization...
  16. Vascular responses as therapeutic targets after SCI
    SCOTT WHITTEMORE; Fiscal Year: 2010
    ..For example, i.v. treatments with the Tie2 ligand angiopoietin-1 (Ang1) plus the v3/51 integrin agonist C16 provide high levels of functional recovery, vascular and tissue protection, ..
  17. Vascular responses as therapeutic targets after SCI
    Theo Hagg; Fiscal Year: 2007
    ..Pharmacological inhibition of VEGF reduces edema, inflammation and tissue loss in stroke models. Angiopoietin 1 (Ang1) induces vessel maturation and reduces leakage in many systems and is reduced after SCI...
  18. VEGF and Angiopoietin 1 Therapy for Stroke
    Zheng Zhang; Fiscal Year: 2003
    In this application, we propose to investigate the roles of vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang 1) in cerebral angiogenesis and blood brain barrier (BBB) leakage after focal cerebral embolic ischemia...
  19. VEGF and Angiopoietin 1 Therapy for Stroke
    Zheng Gang Zhang; Fiscal Year: 2006
    In this application, we propose to investigate the roles of vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang 1) in cerebral angiogenesis and blood brain barrier (BBB) leakage after focal cerebral embolic ischemia...
  20. SNPs in Idopathic Pulmonary Artierial Hypertension
    JASON YUAN; Fiscal Year: 2006
    ..hypothesis that a) specific single nucleotide polymorphysisms (SNPs) in other genes, such as KCNA5 (K+ channel), ANGPT1 (angiopoietin-1), TRPC6 (Ca2+ channel), HTR2B (5-HT receptor) and SLC6A4 (5-HT transporter), are present in IPAH ..
  21. Vascular Maintenance and Brain Tumor Refractory
    P Lin; Fiscal Year: 2007
    ..Interestingly, glioblastoma expresses high levels of Tie2 and its ligands, angiopoietins (Ang1, 2)...
  22. Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
    Dimitar Nikolov; Fiscal Year: 2007
    ..implement this assay to screen a complete compound library for small molecules that disrupt respectively the Tie2/Ang1 and the Tie2/Ang2 complex formation...
  23. Neurorestorative therapy of stroke with agents that increase HDL
    Jieli Chen; Fiscal Year: 2010
    ..We hypothesize that N-or-T treatment of stroke induces endothelial nitric oxide synthase (eNOS) and Angiopoietin-1(Ang1)/Tie2 signaling activity, which increase CBF, angiogenesis and arteriogenesis after stroke in mice...
  24. Neurorestorative therapy of stroke with agents that increase HDL
    Jieli Chen; Fiscal Year: 2009
    ..We hypothesize that N-or-T treatment of stroke induces endothelial nitric oxide synthase (eNOS) and Angiopoietin-1(Ang1)/Tie2 signaling activity, which increase CBF, angiogenesis and arteriogenesis after stroke in mice...
  25. ANGIOGENESIS IN WOUND REPAIR
    LUISA DIPIETRO; Fiscal Year: 2003
    ..of wound repair, including the modulation of FGF-2 and VEGF levels, 2) to identify the role of the angiopoietins (Ang1 and Ang2) in wound angiogenesis, and 3) to determine if an antiangiogenic environment dictates capillary regression ..
  26. THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESIS
    Lawrence Reynolds; Fiscal Year: 2004
    ..Aim 1, we will test Hypothesis l: that major angiogenic factors, namely VEGF, basic FGF (bFGF or FGF 2), and -ANG1, and their receptors, are expressed in a time- and cell-specific fashion throughout gestation...
  27. EXPERIMENTAL APPROACH TO MACULOPATHY
    Stephen Ryan; Fiscal Year: 2004
    ..We propose new studies on the role of the angiopoietins (Ang1, Ang2) in CNV and suggest a new model in which Ang1 and Ang2 act in concert with VEGF to mediate the development of ..