Gene Symbol: ANGPT1
Description: angiopoietin 1
Alias: AGP1, AGPT, ANG1, angiopoietin-1, ANG-1
Species: human
Products:     ANGPT1

Top Publications

  1. Kim K, Choi H, Steinmetz M, Maco B, Kammerer R, Ahn S, et al. Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2. J Biol Chem. 2005;280:20126-31 pubmed
    Angiopoietin-1 (Ang1) is an essential molecule for blood vessel formation; however, little is known about the structure-function relationships of Ang1 with its receptor, Tie2 (tyrosine kinase with immunoglobulin and epidermal growth ..
  2. Silver K, Zhong K, Leke R, Taylor D, Kain K. Dysregulation of angiopoietins is associated with placental malaria and low birth weight. PLoS ONE. 2010;5:e9481 pubmed publisher
    ..falciparum-infected mothers at risk of LBW deliveries. ..
  3. Giuliano J, Lahni P, Harmon K, Wong H, Doughty L, Carcillo J, et al. Admission angiopoietin levels in children with septic shock. Shock. 2007;28:650-654 pubmed
    ..Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted. ..
  4. Lee H, Cho C, Hwang S, Choi H, Kim K, Ahn S, et al. Biological characterization of angiopoietin-3 and angiopoietin-4. FASEB J. 2004;18:1200-8 pubmed
    The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all of which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human) are interspecies orthologs...
  5. Stoeltzing O, Ahmad S, Liu W, McCarty M, Wey J, Parikh A, et al. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res. 2003;63:3370-7 pubmed
    ..Thus, Ang-1 could potentially serve as an antineoplastic or anti-permeability agent for patients with metastatic colorectal cancer. ..
  6. Brouwers J, Noviyanti R, Fijnheer R, de Groot P, Trianty L, Mudaliana S, et al. Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers. PLoS ONE. 2014;8:e64850 pubmed publisher
    ..Evaluation of plasma levels of these angiogenic proteins requires close adherence to a stringent protocol to minimize ex vivo platelet activation. ..
  7. Davis S, Aldrich T, Jones P, Acheson A, Compton D, Jain V, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell. 1996;87:1161-9 pubmed
    ..However, its expression in close proximity with developing blood vessels implicates Angiopoietin-1 in endothelial developmental processes. ..
  8. Oliner J, Min H, Leal J, Yu D, Rao S, You E, et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell. 2004;6:507-16 pubmed
    ..These results imply that specific Ang2 inhibition may represent an effective antiangiogenic strategy for treating patients with solid tumors. ..
  9. Patel J, Lim H, Varughese G, Hughes E, Lip G. Angiopoietin-2 levels as a biomarker of cardiovascular risk in patients with hypertension. Ann Med. 2008;40:215-22 pubmed publisher
    ..Among patients with hypertension, raised levels of Ang-2 were predictive of MI, and further study is warranted to evaluate the use of this biomarker in CVD management, risk stratification, and prevention. ..

More Information


  1. Neagoe P, Brkovic A, Hajjar F, Sirois M. Expression and release of angiopoietin-1 from human neutrophils: intracellular mechanisms. Growth Factors. 2009;27:335-44 pubmed publisher
    We recently demonstrated that Tie2 receptor activation on human neutrophils by both angiopoietins (Ang1 and Ang2) promoted platelet-activating factor synthesis, beta(2)-integrin activation, and cell migration...
  2. Seok S, Heo J, Hwang J, Na Y, Yun J, Lee E, et al. Angiopoietin-1 elicits pro-inflammatory responses in monocytes and differentiating macrophages. Mol Cells. 2013;35:550-6 pubmed publisher
    ..Although Ang1 is a strong Tie2 receptor agonist, little is known regarding the effect of Ang1 on non-endothelial cells, such as ..
  3. Dunk C, Shams M, Nijjar S, Rhaman M, Qiu Y, Bussolati B, et al. Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development. Am J Pathol. 2000;156:2185-99 pubmed
  4. Harfouche R, Malak N, Brandes R, Karsan A, Irani K, Hussain S. Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling. FASEB J. 2005;19:1728-30 pubmed
  5. Neagoe P, Dumas E, Hajjar F, Sirois M. Angiopoietin-1 but not angiopoietin-2 induces IL-8 synthesis and release by human neutrophils. J Cell Physiol. 2012;227:3099-110 pubmed publisher
    ..expression on human neutrophils, which promote chemotactic activities upon activation by both angiopoietins (Ang1 and Ang2)...
  6. Tian S, Hayes A, Metheny Barlow L, Li L. Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1. Br J Cancer. 2002;86:645-51 pubmed
    ..These findings suggest that a vascular stabilization effect of angiopoietin-1 accounts for the inhibition of tumour growth. ..
  7. Geva E, Ginzinger D, Zaloudek C, Moore D, Byrne A, Jaffe R. Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. J Clin Endocrinol Metab. 2002;87:4213-24 pubmed
    ..Quantitative real-time PCR analysis demonstrated that VEGF-A and Ang1 mRNA increased in a linear pattern by 2.5 (not significant) and 2.8%/wk (P = 0...
  8. Sturn D, Feistritzer C, Mosheimer B, Djanani A, Bijuklic K, Patsch J, et al. Angiopoietin affects neutrophil migration. Microcirculation. 2005;12:393-403 pubmed
    ..These effects suggest a role of angiopoietins in modulating neutrophilic inflammation. ..
  9. Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, et al. Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem. 2003;278:1721-7 pubmed
  10. Mitsuhashi N, Shimizu H, Ohtsuka M, Wakabayashi Y, Ito H, Kimura F, et al. Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology. 2003;37:1105-13 pubmed
    ..In conclusion, an increased expression of Ang-2/1 in the presence of VEGF may play a critical role in promoting tumor angiogenesis and progression in human HCC. ..
  11. Kim I, Oh J, Ryu Y, So J, Sessa W, Walsh K, et al. Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells. FASEB J. 2002;16:126-8 pubmed
    ..Angiopoietin-1 (Ang1), a strong activator of intracellular PI 3'-kinase/Akt, inhibited the induction of TF by VEGF and TNF-a, whereas ..
  12. Murakami T, Takagi H, Suzuma K, Suzuma I, Ohashi H, Watanabe D, et al. Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells. J Biol Chem. 2005;280:31841-9 pubmed
    ..We reported here the role of angiopoietin-1 (Ang1), which is a prosurvival factor in endothelial cells, during endothelial cell damage induced by oxidative stress...
  13. Satchell S, Anderson K, Mathieson P. Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties. J Am Soc Nephrol. 2004;15:566-74 pubmed
    ..Podocytes produce endothelial factors, including angiopoietin 1 (ang1), and vascular endothelial growth factor (VEGF), whereas GEnC express their respective receptors Tie2 ..
  14. Fukuhara S, Sako K, Minami T, Noda K, Kim H, Kodama T, et al. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol. 2008;10:513-26 pubmed publisher
    Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1)...
  15. Mammoto T, Parikh S, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, et al. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007;282:23910-8 pubmed
    ..These results provide mechanistic evidence that targeting the endothelium through Tie-2 may offer specific therapeutic strategies in life-threatening endotoxemic conditions such as sepsis and acute respiratory distress syndrome. ..
  16. Lovegrove F, Tangpukdee N, Opoka R, Lafferty E, Rajwans N, Hawkes M, et al. Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS ONE. 2009;4:e4912 pubmed publisher
    ..027). ANG-1 and the ANG-2/1 ratio are promising clinically informative biomarkers for CM. Additional studies should address their utility as prognostic biomarkers and potential therapeutic targets in severe malaria. ..
  17. Lukasz A, Hellpap J, Horn R, Kielstein J, David S, Haller H, et al. Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays. Crit Care. 2008;12:R94 pubmed publisher
    ..According to preclinical and clinical validation, circulating Ang-1 and Ang-2 can be reliably assessed by novel immunoassays in the intensive care unit setting. ..
  18. Schiessl B, Innes B, Bulmer J, Otun H, Chadwick T, Robson S, et al. Localization of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy. Placenta. 2009;30:79-87 pubmed publisher
    ..These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy. ..
  19. Koblizek T, Weiss C, Yancopoulos G, Deutsch U, Risau W. Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr Biol. 1998;8:529-32 pubmed
    ..Although 'knockouts' of the gene encoding the Tie2 receptor, or its activating ligand angiopoietin-1 (Ang1), result in embryonic lethality in mice due to an absence of remodeling and sprouting of blood vessels [4,5], ..
  20. Schubert S, Benarroch A, Monter Solans J, Edelman E. Primary monocytes regulate endothelial cell survival through secretion of angiopoietin-1 and activation of endothelial Tie2. Arterioscler Thromb Vasc Biol. 2011;31:870-5 pubmed publisher
    ..Although primary monocytes contained high levels of both angiopoietin 1 and 2, endothelial cells contained primarily angiopoietin 2...
  21. Procopio W, Pelavin P, Lee W, Yeilding N. Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. J Biol Chem. 1999;274:30196-201 pubmed
  22. Kwak H, So J, Lee S, Kim I, Koh G. Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS Lett. 1999;448:249-53 pubmed
    We examined the effect of angiopoietin-1 (Ang1) on apoptosis in human umbilical vein endothelial cells (HUVECs). Ang1 (5-1000 ng/ml) dose-dependently inhibited apoptosis under a serum-deprived state...
  23. Yuan H, Khankin E, Karumanchi S, Parikh S. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol. 2009;29:2011-22 pubmed publisher
    Angiopoietin 2 (Ang2) was originally shown to be a competitive antagonist for Ang1 of the receptor tyrosine kinase Tie2 in endothelial cells (ECs). Since then, reports have conflicted on whether Ang2 is an agonist or antagonist of Tie2...
  24. Suri C, Jones P, Patan S, Bartunkova S, Maisonpierre P, Davis S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell. 1996;87:1171-80 pubmed
    ..Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. ..
  25. Mofarrahi M, Nouh T, Qureshi S, Guillot L, Mayaki D, Hussain S. Regulation of angiopoietin expression by bacterial lipopolysaccharide. Am J Physiol Lung Cell Mol Physiol. 2008;294:L955-63 pubmed publisher
  26. Michels M, van der Ven A, Djamiatun K, Fijnheer R, de Groot P, Griffioen A, et al. Imbalance of angiopoietin-1 and angiopoetin-2 in severe dengue and relationship with thrombocytopenia, endothelial activation, and vascular stability. Am J Trop Med Hyg. 2012;87:943-6 pubmed publisher
    ..Dengue-associated thrombocytopenia and endothelial activation are associated with an imbalance in angiopoietin-2: angiopoietin-1 plasma levels. This imbalance may contribute to the transient plasma leakage in DHF/DSS. ..
  27. Torimura T, Ueno T, Kin M, Harada R, Taniguchi E, Nakamura T, et al. Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma. J Hepatol. 2004;40:799-807 pubmed
    ..Our findings indicate that the increased expression of Angiopoietin-1 and Angiopoietin-2 play a critical role in the process of vascular development in HCC. ..
  28. Cascone I, Audero E, Giraudo E, Napione L, Maniero F, Philips M, et al. Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1. Blood. 2003;102:2482-90 pubmed
    ..Taken together, these results further expand our understanding of angiopoietin-1-mediated endothelial cell motility during vascular network assembly and angiogenesis. ..
  29. Maisonpierre P, Suri C, Jones P, Bartunkova S, Wiegand S, Radziejewski C, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science. 1997;277:55-60 pubmed
    Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2 receptor tyrosine kinase...
  30. Tammela T, Saaristo A, Lohela M, Morisada T, Tornberg J, Norrmen C, et al. Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood. 2005;105:4642-8 pubmed
    b>Angiopoietin 1 (Ang1), a ligand for the receptor tyrosine kinase Tie2, regulates the formation and stabilization of the blood vessel network during embryogenesis...
  31. Marron M, Singh H, Tahir T, Kavumkal J, Kim H, Koh G, et al. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. J Biol Chem. 2007;282:30509-17 pubmed
    ..and generation of phosphorylated receptor fragments in the presence of cartilage oligomeric protein angiopoietin 1. A key function of gamma-secretase is in preventing accumulation of these phosphorylated fragments...
  32. Lemieux C, Maliba R, Favier J, Théorêt J, Merhi Y, Sirois M. Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. Blood. 2005;105:1523-30 pubmed
    Angiopoietin-1 (Ang1) and -2 (Ang2) are endothelial growth factors that bind to the tyrosine kinase receptor Tie2 and contribute to orchestrate blood vessel formation during angiogenesis...
  33. Seval Y, Sati L, Celik Ozenci C, Taskin O, Demir R. The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta. Placenta. 2008;29:809-15 pubmed publisher
  34. Peters K, Kontos C, Lin P, Wong A, Rao P, Huang L, et al. Functional significance of Tie2 signaling in the adult vasculature. Recent Prog Horm Res. 2004;59:51-71 pubmed
    ..Tie2 extracellular domain (ExTek) was designed that blocked the activation of Tie2 by its activating ligand, angiopoietin 1 (Ang1)...
  35. Witzenbichler B, Maisonpierre P, Jones P, Yancopoulos G, Isner J. Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. J Biol Chem. 1998;273:18514-21 pubmed
  36. Satchell S, Harper S, Mathieson P. Angiopoietin-1 is normally expressed by periendothelial cells. Thromb Haemost. 2001;86:1597-8 pubmed
  37. Onimaru M, Yonemitsu Y, Suzuki H, Fujii T, Sueishi K. An autocrine linkage between matrix metalloproteinase-14 and Tie-2 via ectodomain shedding modulates angiopoietin-1-dependent function in endothelial cells. Arterioscler Thromb Vasc Biol. 2010;30:818-26 pubmed publisher
  38. Mei S, McCarter S, Deng Y, Parker C, Liles W, Stewart D. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med. 2007;4:e269 pubmed
    ..hypothesized that mesenchymal stem cells (MSCs), with or without transfection with the vasculoprotective gene angiopoietin 1 (ANGPT1) would have beneficial effects in experimental ALI in mice...
  39. van der Valk R, Duijts L, Timpson N, Salam M, Standl M, Curtin J, et al. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014;134:46-55 pubmed publisher
    ..This study highlights that both shared and distinct genetic factors affect Feno values and childhood asthma. ..
  40. Pandey A, Goru S, Kadakol A, Malek V, Gaikwad A. Differential regulation of angiotensin converting enzyme 2 and nuclear factor-κB by angiotensin II receptor subtypes in type 2 diabetic kidney. Biochimie. 2015;118:71-81 pubmed publisher
    ..axis to promote renal failure whereas the Ang II type 2 receptor (AT2R)/Angiotensin Converting Enzyme 2 (ACE2)/Ang1-7/Mas axis constitutes the protective arm of Renin Angiotensin System (RAS)...
  41. Cheung A, Stewart R, Marsden P. Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. Genomics. 1998;48:389-91 pubmed
  42. Scotti L, Abramovich D, Pascuali N, Durand L, Irusta G, de Zúñiga I, et al. Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS). Reprod Fertil Dev. 2016;28:690-9 pubmed publisher
    ..Here, we investigated the effect of ANGPT1 inhibition on ovarian angiogenesis in follicular fluid (FF) from women at risk of OHSS, using the chorioallantoic ..
  43. Keikkala E, Hytinantti T, Wathen K, Andersson S, Vuorela P. Significant decrease in maternal serum concentrations of angiopoietin-1 and -2 after delivery. Acta Obstet Gynecol Scand. 2012;91:917-22 pubmed publisher
    ..Maternal Ang-1 and Ang-2 concentrations decreased following delivery. Umbilical concentrations of Ang-1 and Tie-2 were higher than the maternal concentrations. ..
  44. Abuohashish H, Ahmed M, Sabry D, Khattab M, Al Rejaie S. The ACE-2/Ang1-7/Mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade. Eur J Pharmacol. 2017;807:44-55 pubmed publisher
    ..Angiotensin1-7 (Ang1-7) is a beneficial member of the RAS, and the therapeutic effects of a large number of angiotensin receptors ..
  45. Li X, Hu Y, Chen Y, Zhou H, Zhang F, Guo D, et al. Mechanisms of Improvement of Left Ventricular Function by Intracoronary Human Umbilical Cord-Derived Mesenchymal Stem Cell Infusion in Very Old Patients with Coronary Chronic Total Occlusion. Curr Pharm Des. 2015;21:3844-50 pubmed
    ..factor receptor-1 (sTNFR-1), soluble tumor necrosis factor receptor-2 (sTNFR-2), NT-proBNP, BNP, angiotensin 1-7 (Ang1-7), angiotensin II (Ang II) and aldosterone (Ald) in patients with hUCMSC therapy at baseline, 12, and 24 months...
  46. Walton R, Finlin B, Mula J, Long D, Zhu B, Fry C, et al. Insulin-resistant subjects have normal angiogenic response to aerobic exercise training in skeletal muscle, but not in adipose tissue. Physiol Rep. 2015;3: pubmed publisher
    ..In the presence of VEGFA, Angiopoietin-2 (Angpt2) and Angiopoietin-1 (Angpt1) are central determinants of angiogenesis, with greater Angpt2:Angpt1 ratios promoting angiogenesis...
  47. Aguirre Palma L, Flamme H, Gerke I, Kreuzer K. Angiopoietins Modulate Survival, Migration, and the Components of the Ang-Tie2 Pathway of Chronic Lymphocytic Leukaemia (CLL) Cells In Vitro. Cancer Microenviron. 2016;9:13-26 pubmed publisher
    ..Here we evaluate the status of the Ang-Tie2 pathway in CLL cells and assess Ang1 levels in plasma/cell medium from CLL samples...
  48. Bai Y, Rottwinkel G, Feng J, Liu Y, Lamparter T. Bacteriophytochromes control conjugation in Agrobacterium fabrum. J Photochem Photobiol B. 2016;161:192-9 pubmed publisher
    ..With this assay, conjugation in Agrobacterium fabrum was modulated by the phytochromes Agp1 and Agp2, photoreceptors that are most sensitive in the red region of visible light...
  49. Kreuzer M, Sollmann L, Ruben S, Leifheit Nestler M, Fischer D, Pape L, et al. Endothelial dysfunction during long-term follow-up in children with STEC hemolytic-uremic syndrome. Pediatr Nephrol. 2017;32:1005-1011 pubmed publisher
    ..Endothelial dysfunction was present in 13 patients, and the mean serum Ang2/Ang1 ratio was increased compared to healthy children (each p < 0.05)...
  50. Huang C, Walker M, Fedrizzi B, Gardner R, Jiranek V. Yeast genes involved in regulating cysteine uptake affect production of hydrogen sulfide from cysteine during fermentation. FEMS Yeast Res. 2017;17: pubmed publisher
    ..We then examined the nine known cysteine permeases and found that deletion of AGP1, GNP1 and MUP1 led to reduced production of H2S from cysteine...
  51. Golledge J, Clancy P, Maguire J, Lincz L, Koblar S, McEvoy M, et al. Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence. Stroke. 2014;45:1064-8 pubmed publisher
    Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome...
  52. Kopczynska E, Makarewicz R, Biedka M, Kaczmarczyk A, Kardymowicz H, Tyrakowski T. Plasma concentration of angiopoietin-1, angiopoietin-2 and Tie-2 in cervical cancer. Eur J Gynaecol Oncol. 2009;30:646-9 pubmed
    ..Plasma concentrations of Ang- 1, Ang-2 and Tie-2 may be useful additional tumor markers in cervical cancer. ..
  53. Tseliou E, Bakakos P, Kostikas K, Hillas G, Mantzouranis K, Emmanouil P, et al. Increased levels of angiopoietins 1 and 2 in sputum supernatant in severe refractory asthma. Allergy. 2012;67:396-402 pubmed publisher
    ..In SRA, Ang-2 is associated with mediators involved in both the inflammatory and the vascular remodeling processes. ..
  54. Dallabrida S, Ismail N, Oberle J, Himes B, Rupnick M. Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins. Circ Res. 2005;96:e8-24 pubmed
    ..Angiopoietin-1 may prove therapeutically valuable in cardiac remodeling by supporting myocyte viability and preserving pump function. The full text of this article is available online at ..
  55. Al Zoubi N, Yaghan R, Mazahreh T, Hijazi E, Alqudah A, Owaisy Y, et al. Evaluation of Plasma Growth Factors (VEGF, PDGF, EGF, ANG1, and ANG2) in Patients with Varicose Veins Before and After Treatment with Endovenous Laser Ablation. Photomed Laser Surg. 2017;: pubmed publisher
    To measure pre- and postoperative plasma concentrations of growth factors (VEGF, PDGF, EGF, ANG1, and ANG2) in patients with primary lower limb varicose veins (VVs) treated with endovenous laser ablation (EVLA).
  56. Daponte A, Deligeoroglou E, Pournaras S, Tsezou A, Garas A, Anastasiadou F, et al. Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion: a case-control study. Clin Chim Acta. 2013;415:145-51 pubmed publisher
    ..Serum ANG-1 showed potential to discriminate MA from EP. ..
  57. Yoon M, Cho C, Lee C, Jang I, Ryu S, Koh G. Localization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cells. Biochem Biophys Res Commun. 2003;308:101-5 pubmed
    Angiopoietin-1 (Ang1) and its receptor, Tie2, play critical roles in blood vessel formation. Ang1 triggers a variety of signaling events in endothelial cells leading to vasculogenic and angiogenic processes...
  58. Zadeh G, Reti R, Koushan K, Baoping Q, Shannon P, Guha A. Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1. Neoplasia. 2005;7:1081-90 pubmed
    ..We have observed that overexpression of angiopoietin-1 (Ang1) in both subcutaneous and intracranial xenograft models of malignant astrocytomas reproduces many of the vascular ..
  59. Hatfield K, Hovland R, Øyan A, Kalland K, Ryningen A, Gjertsen B, et al. Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels. Leukemia. 2008;22:287-93 pubmed
    ..Local Ang-2 release from AML cells is less common, but high systemic levels of Ang-2 may affect bone marrow angioregulation. ..
  60. Mofarrahi M, McClung J, Kontos C, Davis E, Tappuni B, Moroz N, et al. Angiopoietin-1 enhances skeletal muscle regeneration in mice. Am J Physiol Regul Integr Comp Physiol. 2015;308:R576-89 pubmed publisher
  61. Stoeltzing O, Ahmad S, Liu W, McCarty M, Parikh A, Fan F, et al. Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis. Br J Cancer. 2002;87:1182-7 pubmed
    ..05). Our results suggest that angiopoietin-1 is an important mediator of angiogenesis and vascular permeability and thus could theoretically serve as an anti-neoplastic agent for patients with carcinomatosis from colorectal cancer. ..
  62. Falcon B, Hashizume H, Koumoutsakos P, Chou J, Bready J, Coxon A, et al. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol. 2009;175:2159-70 pubmed publisher
    Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have complex actions in angiogenesis and vascular remodeling due to their effects on Tie2 receptor signaling...
  63. Joshi S, Khan R, Sharma M, Kumar L, Sharma A. Angiopoietin-2: a potential novel diagnostic marker in multiple myeloma. Clin Biochem. 2011;44:590-5 pubmed publisher
  64. Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, et al. Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J Biol Chem. 2009;284:29109-24 pubmed publisher
    ..Together, these findings suggest that GATA3 is indispensable for Ang-1-Tie2-mediated signaling in large vessel endothelial cells. ..
  65. Iivanainen E, Nelimarkka L, Elenius V, Heikkinen S, Junttila T, Sihombing L, et al. Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor. FASEB J. 2003;17:1609-21 pubmed
    ..These results suggest an important role for HB-EGF and ErbB receptors in the recruitment of SMCs by ECs and elaborate on the mechanism by which angiopoietins exert their vascular effects. ..
  66. Huang J, Bae J, Tsai J, Kadenhe Chiweshe A, Papa J, Lee A, et al. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int J Oncol. 2009;34:79-87 pubmed
    ..Expression of an Ang-1 construct (Ang1*) did not significantly change tumor growth in our model prior to treatment, although vessels exhibited changes ..