ANG

Summary

Gene Symbol: ANG
Description: angiogenin
Alias: ALS9, HEL168, RAA1, RNASE4, RNASE5, angiogenin, RNase 5, angiogenin, ribonuclease, RNase A family, 5, epididymis luminal protein 168, ribonuclease 5, ribonuclease A A1, ribonuclease A family member 5
Species: human
Products:     ANG

Top Publications

  1. Hu G, Xu C, Riordan J. Human angiogenin is rapidly translocated to the nucleus of human umbilical vein endothelial cells and binds to DNA. J Cell Biochem. 2000;76:452-62 pubmed
    Human angiogenin is translocated to the nucleus of human umbilical vein endothelial cells in a time-dependent manner...
  2. Paubel A, Violette J, Amy M, Praline J, Meininger V, Camu W, et al. Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis. Arch Neurol. 2008;65:1333-6 pubmed publisher
    Mutations in the angiogenin gene, ANG, have been associated recently with familial and sporadic forms of amyotrophic lateral sclerosis (ALS)...
  3. Campo L, Turley H, Han C, Pezzella F, Gatter K, Harris A, et al. Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival. J Pathol. 2005;205:585-91 pubmed
    b>Angiogenin, a 14.2 kD polypeptide that was originally noted for its angiogenic activity, is now increasingly recognized to have a multiplicity of biological roles in both physiological and pathological conditions...
  4. Greenway M, Alexander M, Ennis S, Traynor B, Corr B, Frost E, et al. A novel candidate region for ALS on chromosome 14q11.2. Neurology. 2004;63:1936-8 pubmed
    ..The gene for a related protein, angiogenin, lies on chromosome 14q11.2...
  5. Xu Z, Tsuji T, Riordan J, Hu G. Identification and characterization of an angiogenin-binding DNA sequence that stimulates luciferase reporter gene expression. Biochemistry. 2003;42:121-8 pubmed
    b>Angiogenin undergoes nuclear translocation in endothelial and smooth muscle cells where it accumulates in the nucleolus and binds to DNA...
  6. Nakamura M, Yamabe H, Osawa H, Nakamura N, Shimada M, Kumasaka R, et al. Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture. Nephrol Dial Transplant. 2006;21:1489-95 pubmed
    ..Cultured PTEC were exposed to normal and low-oxygen conditions. The levels of angiogenin (ANG) and vascular endothelial growth factor (VEGF) in the cell supernatants were measured by enzyme-linked ..
  7. Rajashekhar G, Loganath A, Roy A, Wong Y. Expression and localization of angiogenin in placenta: enhanced levels at term over first trimester villi. Mol Reprod Dev. 2002;62:159-66 pubmed
    Human angiogenin, a 14-kDa non-glycosylated polypeptide with both angiogenic and ribonucleolytic activities, is implicated in angiogenesis, a complex process of proliferation and formation of new capillary blood vessels from existing ..
  8. Xia W, Fu W, Cai L, Kong H, Cai X, Liu J, et al. Identification and characterization of FHL3 as a novel angiogenin-binding partner. Gene. 2012;504:233-7 pubmed publisher
    b>Angiogenin (Ang) is known to induce cell proliferation and inhibit apoptosis by cellular signaling pathways and by direct nuclear functions of Ang, but the mechanism of action for Ang is not yet clear...
  9. Moroianu J, Riordan J. Identification of the nucleolar targeting signal of human angiogenin. Biochem Biophys Res Commun. 1994;203:1765-72 pubmed
    b>Angiogenin is endocytosed by subconfluent endothelial cells, translocated to the nucleus and accumulates in the nucleolus. It also localizes into the nucleolus of digitonin-permeabilized endothelial cells...

More Information

Publications68

  1. Shapiro R, Riordan J, Vallee B. Characteristic ribonucleolytic activity of human angiogenin. Biochemistry. 1986;25:3527-32 pubmed
    b>Angiogenin, a blood vessel inducing protein isolated from a human tumor cell line, has been found to exhibit ribonucleolytic activity...
  2. Bicknell R, Vallee B. Angiogenin activates endothelial cell phospholipase C. Proc Natl Acad Sci U S A. 1988;85:5961-5 pubmed
    Low concentrations of angiogenin activate the inositol-specific phospholipase C of cultured pulmonary artery, umbilical vein, and capillary endothelial cells, promoting a transient increase in the intracellular levels of 1,2-..
  3. Hu G, Strydom D, Fett J, Riordan J, Vallee B. Actin is a binding protein for angiogenin. Proc Natl Acad Sci U S A. 1993;90:1217-21 pubmed
    The 42-kDa angiogenin binding protein isolated previously has been purified to electrophoretic homogeneity. It has been identified as a member of the actin family by peptide mapping and partial amino acid sequencing...
  4. Strydom D, Fett J, Lobb R, Alderman E, Bethune J, Riordan J, et al. Amino acid sequence of human tumor derived angiogenin. Biochemistry. 1985;24:5486-94 pubmed
    The amino acid sequence and disulfide bond pairing of human tumor derived angiogenin, the first tumor angiogenesis factor to be isolated in pure form from human sources, have been determined by conventional sequencing techniques adapted ..
  5. Pyatibratov M, Tolkatchev D, Plamondon J, Xu P, Ni F, Kostyukova A. Binding of human angiogenin inhibits actin polymerization. Arch Biochem Biophys. 2010;495:74-81 pubmed publisher
    b>Angiogenin is a potent inducer of angiogenesis, a process of blood vessel formation. It interacts with endothelial and other cells and elicits a wide range of cellular responses including migration, proliferation, and tube formation...
  6. Steidinger T, Slone S, Ding H, Standaert D, Yacoubian T. Angiogenin in Parkinson disease models: role of Akt phosphorylation and evaluation of AAV-mediated angiogenin expression in MPTP treated mice. PLoS ONE. 2013;8:e56092 pubmed publisher
    The angiogenic factor, angiogenin, has been recently linked to both Amyotrophic Lateral Sclerosis (ALS) and Parkinson Disease (PD)...
  7. Kim Y, Kim D. Decreased serum angiogenin level in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38:116-20 pubmed publisher
    ..A few studies on the roles of VEGF in AD have been reported recently. But, the results were inconsistent. Angiogenin, which is suspected to have a similar function as VEGF, however, has not yet been studied in patients with AD...
  8. Wu D, Yu W, Kishikawa H, Folkerth R, Iafrate A, Shen Y, et al. Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis. Ann Neurol. 2007;62:609-17 pubmed
    Heterozygous missense mutations in the coding region of angiogenin (ANG), an angiogenic ribonuclease, have been reported in amyotrophic lateral sclerosis (ALS) patients...
  9. Koga K, Osuga Y, Tsutsumi O, Momoeda M, Suenaga A, Kugu K, et al. Evidence for the presence of angiogenin in human follicular fluid and the up-regulation of its production by human chorionic gonadotropin and hypoxia. J Clin Endocrinol Metab. 2000;85:3352-5 pubmed
    ..We investigated the presence of angiogenin, a potent inducer of angiogenesis, and the regulatory mechanisms of its production in the human ovary...
  10. Conforti F, Sprovieri T, Mazzei R, Ungaro C, La Bella V, Tessitore A, et al. A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy. Neuromuscul Disord. 2008;18:68-70 pubmed
    Mutations in the Angiogenin gene (ANG) linked to 14q11.2 have been recently discovered to be associated with Amyotrophic Lateral Sclerosis (ALS) in Irish and Scottish populations...
  11. Hooper L, Stappenbeck T, Hong C, Gordon J. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol. 2003;4:269-73 pubmed
    ..We show that a previously uncharacterized angiogenin, Ang4, is produced by mouse Paneth cells, is secreted into the gut lumen and has bactericidal activity against ..
  12. Moroianu J, Riordan J. Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity. Proc Natl Acad Sci U S A. 1994;91:1677-81 pubmed
    The intracellular pathway of human angiogenin in calf pulmonary artery endothelial (CPAE) cells has been studied by immunofluorescence microscopy...
  13. Shapiro R, Vallee B. Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis. Biochemistry. 1989;28:7401-8 pubmed
    The roles of His-13 and His-114 in the ribonucleolytic and angiogenic activities of human angiogenin have been investigated by site-directed mutagenesis...
  14. Oikonomou K, Kapsoritakis A, Kapsoritaki A, Manolakis A, Tiaka E, Tsiopoulos F, et al. Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease. Inflamm Bowel Dis. 2011;17:963-70 pubmed publisher
    ..The objective of this study was to assess serum levels of angiogenin, angiopoietin-1, angiopoietin-2, and endostatin in IBD patients...
  15. Sadagopan S, Sharma Walia N, Veettil M, Bottero V, Levine R, Vart R, et al. Kaposi's sarcoma-associated herpesvirus upregulates angiogenin during infection of human dermal microvascular endothelial cells, which induces 45S rRNA synthesis, antiapoptosis, cell proliferation, migration, and angiogenesis. J Virol. 2009;83:3342-64 pubmed publisher
    ..growth factors, cytokines, chemokines, and angiogenic factors, and the multifunctional angiogenic protein angiogenin is one of them...
  16. Kim H, Kang D, Kim H, Kang S, Chang S. Angiogenin-induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells. Biochem Biophys Res Commun. 2007;352:509-13 pubmed
    b>Angiogenin, a potent angiogenic factor, binds to endothelial cells and is endocytosed and rapidly translocated to and concentrated in the nucleolus where it binds to DNA...
  17. Del Bo R, Scarlato M, Ghezzi S, Martinelli Boneschi F, Corti S, Locatelli F, et al. Absence of angiogenic genes modification in Italian ALS patients. Neurobiol Aging. 2008;29:314-6 pubmed
    To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic determinants in the susceptibility to sporadic ALS in Italian patients...
  18. Suzumori N, Zhao X, Suzumori K. Elevated angiogenin levels in the peritoneal fluid of women with endometriosis correlate with the extent of the disorder. Fertil Steril. 2004;82:93-6 pubmed
    To assess the release of angiogenin into peritoneal fluid in women with and without endometriosis by measuring its concentration with reference to disease stage, presence of red lesions, and phase of the menstrual cycle...
  19. McLaughlin R, Phukan J, MCCORMACK W, Lynch D, Greenway M, Cronin S, et al. Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis. PLoS ONE. 2010;5:e15402 pubmed publisher
    ..We also assessed the contribution of genotype to angiogenin levels in plasma and CSF...
  20. Sadagopan S, Valiya Veettil M, Paudel N, Bottero V, Chandran B. Kaposi's sarcoma-associated herpesvirus-induced angiogenin plays roles in latency via the phospholipase C gamma pathway: blocking angiogenin inhibits latent gene expression and induces the lytic cycle. J Virol. 2011;85:2666-85 pubmed publisher
    ..endothelial cells (HMVEC-d), Kaposi's sarcoma-associated herpesvirus (KSHV) induced the multifunctional angiogenin (ANG) protein, which entered the nuclei and nucleoli of infected cells and stimulated 45S rRNA gene ..
  21. Hu G. Neomycin inhibits angiogenin-induced angiogenesis. Proc Natl Acad Sci U S A. 1998;95:9791-5 pubmed
    A class of angiogenesis inhibitor has emerged from our mechanistic study of the action of angiogenin, a potent angiogenic factor...
  22. Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu G, et al. Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer. Oral Oncol. 2012;48:1120-7 pubmed publisher
    b>Angiogenin (ANG) is a prominent angiogenic factor that has been shown to have a dual effect on tumor progression by inducing both angiogenesis and cancer cell proliferation through stimulating ribosomal RNA transcription in both ..
  23. Liu B, Zhang Y, Wang Y, Xiao Q, Yang Q, Wang G, et al. Angiogenin variants are not associated with Parkinson's disease in the ethnic Chinese population. Parkinsonism Relat Disord. 2013;19:446-7 pubmed publisher
    Recently, the angiogenin gene has been reported to be significantly associated with Parkinson's disease and amyotrophic lateral sclerosis in populations of European and American ancestry...
  24. Sheng J, Yu W, Gao X, Xu Z, Hu G. Angiogenin stimulates ribosomal RNA transcription by epigenetic activation of the ribosomal DNA promoter. J Cell Physiol. 2014;229:521-9 pubmed publisher
    b>Angiogenin (ANG) undergoes nuclear translocation and promotes ribosomal RNA (rRNA) transcription thereby enhancing cell growth and proliferation. However, the mode of action of ANG in stimulating rRNA transcription is unclear...
  25. van Es M, Schelhaas H, Van Vught P, Ticozzi N, Andersen P, Groen E, et al. Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. Ann Neurol. 2011;70:964-73 pubmed publisher
    Several studies have suggested an increased frequency of variants in the gene encoding angiogenin (ANG) in patients with amyotrophic lateral sclerosis (ALS)...
  26. Wei S, Gao X, Du J, Su J, Xu Z. Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics. PLoS ONE. 2011;6:e28797 pubmed publisher
    b>Angiogenin (ANG) acts on both vascular endothelial cells and cancer cells, but the underlying mechanism remains elusive...
  27. Cho G, Kang B, Kim S. Human angiogenin presents neuroprotective and migration effects in neuroblastoma cells. Mol Cell Biochem. 2010;340:133-41 pubmed publisher
    Human angiogenin (ANG) has been highlighted as an angiogenic factor which supports primary and metastatic tumor growth...
  28. Crabtree B, Thiyagarajan N, Prior S, Wilson P, Iyer S, Ferns T, et al. Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis. Biochemistry. 2007;46:11810-8 pubmed
    Human angiogenin (ANG), the first member of the angiogenin family (from the pancreatic ribonuclease A superfamily) to be identified, is an angiogenic factor that induces neovascularization...
  29. Padhi A, Kumar H, Vasaikar S, Jayaram B, Gomes J. Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis. PLoS ONE. 2012;7:e32479 pubmed publisher
    Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG)...
  30. Gellera C, Colombrita C, Ticozzi N, Castellotti B, Bragato C, Ratti A, et al. Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. Neurogenetics. 2008;9:33-40 pubmed
    b>Angiogenin (ANG) gene, coding for an angiogenic factor up-regulated by hypoxia and expressed in ventral horn motor neurons, is a novel candidate for the pathogenesis of amyotrophic lateral sclerosis (ALS)...
  31. Corrado L, Battistini S, Penco S, Bergamaschi L, Testa L, Ricci C, et al. Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population. J Neurol Sci. 2007;258:123-7 pubmed
    Potentially causative missense variations in the ANG gene and a positive association with the synonymous rs11701-G substitution was detected mainly in Irish and Scottish ALS patients...
  32. Shapiro R, Strydom D, Olson K, Vallee B. Isolation of angiogenin from normal human plasma. Biochemistry. 1987;26:5141-6 pubmed
    b>Angiogenin, a potent blood vessel inducing protein, was previously isolated from medium conditioned by a human adenocarcinoma cell line [Fett, J. W., Strydom, D.J., Lobb, R.R., Alderman, E.M., Bethune, J.L., Riordan, J.F., & Vallee, B...
  33. Hu G, Riordan J, Vallee B. A putative angiogenin receptor in angiogenin-responsive human endothelial cells. Proc Natl Acad Sci U S A. 1997;94:2204-9 pubmed
    b>Angiogenin stimulates both [3H]thymidine incorporation and proliferation of human endothelial cells in sparse cultures. Under these conditions, a 170-kDa cell surface protein can be detected that binds angiogenin specifically...
  34. Hu H, Gao X, Sun Y, Zhou J, Yang M, Xu Z. Alpha-actinin-2, a cytoskeletal protein, binds to angiogenin. Biochem Biophys Res Commun. 2005;329:661-7 pubmed
    b>Angiogenin is an angiogenic factor which is involved in tumorigenesis. However, no particular intracellular protein is known to interact directly with angiogenin...
  35. Steidinger T, Standaert D, Yacoubian T. A neuroprotective role for angiogenin in models of Parkinson's disease. J Neurochem. 2011;116:334-41 pubmed publisher
    We previously observed marked down-regulation of the mRNA for angiogenin, a potent inducer of neovascularization, in a mouse model of Parkinson's disease (PD) based on over-expression of alpha-synuclein...
  36. Kishimoto K, Liu S, Tsuji T, Olson K, Hu G. Endogenous angiogenin in endothelial cells is a general requirement for cell proliferation and angiogenesis. Oncogene. 2005;24:445-56 pubmed
    b>Angiogenin is an angiogenic protein that undergoes nuclear translocation in endothelial cells where it accumulates in the nucleolus and stimulates rRNA transcription, a rate-limiting step in ribosome biogenesis, protein translation, and ..
  37. Pavlov N, Hatzi E, Bassaglia Y, Frendo J, Evain Brion D, Badet J. Angiogenin distribution in human term placenta, and expression by cultured trophoblastic cells. Angiogenesis. 2003;6:317-30 pubmed
    Human angiogenin is a 14-kDa secreted protein with angiogenic and ribonucleolytic activities. Angiogenin is associated with tumour development but is also present in normal biological fluids and tissues...
  38. Yamasaki S, Ivanov P, Hu G, Anderson P. Angiogenin cleaves tRNA and promotes stress-induced translational repression. J Cell Biol. 2009;185:35-42 pubmed publisher
    ..We show that angiogenin, a secreted ribonuclease, is required for stress-induced production of tiRNAs...
  39. Fernández Santiago R, Hoenig S, Lichtner P, Sperfeld A, Sharma M, Berg D, et al. Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. J Neurol. 2009;256:1337-42 pubmed publisher
    ..Recently, missense variants in the angiogenin gene (ANG), an angiogenic factor expressed in ventral horn motor neurons that is up-regulated by hypoxia, have ..
  40. Li S, Hu M, Sun Y, Yoshioka N, Ibaragi S, Sheng J, et al. Angiogenin mediates androgen-stimulated prostate cancer growth and enables castration resistance. Mol Cancer Res. 2013;11:1203-14 pubmed publisher
    ..However, the mechanism by which AR regulates rRNA transcription is unknown. Here, investigation revealed that angiogenin (ANG), a member of the secreted ribonuclease superfamily, is upregulated in prostate cancer and mediates ..
  41. Tsuji T, Sun Y, Kishimoto K, Olson K, Liu S, Hirukawa S, et al. Angiogenin is translocated to the nucleus of HeLa cells and is involved in ribosomal RNA transcription and cell proliferation. Cancer Res. 2005;65:1352-60 pubmed
    b>Angiogenin is an angiogenic protein known to play a role in rRNA transcription in endothelial cells. Nuclear translocation of angiogenin in endothelial cells decreases as cell density increases and ceases when cells are confluent...
  42. Shapiro R, Vallee B. Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin. Proc Natl Acad Sci U S A. 1987;84:2238-41 pubmed
    Human placental ribonuclease inhibitor (PRI) abolishes both the ribonucleolytic activity of angiogenin toward 28S and 18S rRNA and its angiogenic activity on the chicken embryo chorioallantoic membrane...
  43. Leonidas D, Shapiro R, Allen S, Subbarao G, Veluraja K, Acharya K. Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth. J Mol Biol. 1999;285:1209-33 pubmed
    Human angiogenin (Ang), an unusual member of the pancreatic RNase superfamily, is a potent inducer of angiogenesis in vivo...
  44. Weiner H, Weiner L, Swain J. Tissue distribution and developmental expression of the messenger RNA encoding angiogenin. Science. 1987;237:280-2 pubmed
    ..The polypeptide angiogenin induces new blood vessel growth in two biological assays and may play a role in the vascular development of the ..
  45. Ueki M, Takeshita H, Fujihara J, Takatsuka H, Yuasa I, Iida R, et al. Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations. Cell Biochem Funct. 2008;26:718-22 pubmed publisher
    b>Angiogenin and ribonuclease 2 (RNase 2) are members of the human RNase superfamily...
  46. Hatzi E, Badet J. Expression of receptors for human angiogenin in vascular smooth muscle cells. Eur J Biochem. 1999;260:825-32 pubmed
    Human angiogenin is a plasma protein with angiogenic and ribonucleolytic activities. Angiogenin inhibited both DNA replication and proliferation of aortic smooth muscle cells...
  47. Saxena S, Rybak S, Davey R, Youle R, Ackerman E. Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily. J Biol Chem. 1992;267:21982-6 pubmed
    b>Angiogenin is a 14.4-kDa human plasma protein with 65% homology to RNase A that retains the key active site residues and three of the four RNase A disulfide bonds...
  48. Tabata C, Tabata R, Nakano T. Calpeptin Prevents Malignant Pleural Mesothelioma Cell Proliferation via the Angiopoietin1/Tie2 System. Asian Pac J Cancer Prev. 2016;17:3405-9 pubmed
    ..It also prevented 1) the expression of angiopoietin (Ang)1 and Tie2 mRNA in MPM cells, but not mesothelial cells and 2) the Ang1induced proliferation of MPM cells through ..
  49. Wu F, Pàez Ribes M, Xu P, Man S, Bogdanovic E, Thurston G, et al. Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer. Sci Rep. 2016;6:36694 pubmed publisher
    ..In conclusion, concurrent VEGF pathway inhibition is more likely than Ang/Tie2 pathway inhibition (e.g...
  50. Dobbeleers T, Daens D, Miele S, D aes J, Caluwé M, Geuens L, et al. Performance of aerobic nitrite granules treating an anaerobic pre-treated wastewater originating from the potato industry. Bioresour Technol. 2017;226:211-219 pubmed publisher
    ..Thereafter, SBR performance was investigated during the formation of aerobic nitrite granules (ANG). The first granules appeared after 26days leading to full granulation after 64days...
  51. Márquez Miranda V, Abrigo J, Rivera J, Araya Durán I, Aravena J, Simon F, et al. The complex of PAMAM-OH dendrimer with Angiotensin (1-7) prevented the disuse-induced skeletal muscle atrophy in mice. Int J Nanomedicine. 2017;12:1985-1999 pubmed publisher
    Angiotensin (1-7) (Ang-(1-7)) is a bioactive heptapeptide with a short half-life and has beneficial effects in several tissues - among them, skeletal muscle - by preventing muscle atrophy...
  52. Takezako T, Unal H, Karnik S, Node K. Current topics in angiotensin II type 1 receptor research: Focus on inverse agonism, receptor dimerization and biased agonism. Pharmacol Res. 2017;123:40-50 pubmed publisher
    Although the octapeptide hormone angiotensin II (Ang II) regulates cardiovascular and renal homeostasis through the Ang II type 1 receptor (AT1R), overstimulation of AT1R causes various human diseases, such as hypertension and cardiac ..
  53. Yahya S, Abdelhamid A, Abd Elhalim M, Elsayed G, Eskander E. The effect of newly synthesized progesterone derivatives on apoptotic and angiogenic pathway in MCF-7 breast cancer cells. Steroids. 2017;126:15-23 pubmed publisher
    ..The expression levels of Bcl-2, survivin, CCND1, CDC2, P53 and P21, VEGF, Hif-1?, MMP-2, MMP-9, Ang-1, Ang-2, and FGF-1 genes were investigated using QRT-PCR (Quantitative real time-polymerase chain reaction)...
  54. Berthold P. Noma: a forgotten disease. Dent Clin North Am. 2003;47:559-74 pubmed
    ..Noma often starts as an ulcer on the oral mucosa or as ANG and commonly after a bout of measles or other disease...
  55. Pahlitzsch T, Liu Z, Al Masri A, Braun D, Dietze S, Persson P, et al. Hypoxia/reoxygenation enhances murine afferent arteriolar vasoconstriction by angiotensin II. Am J Physiol Renal Physiol. 2017;:ajprenal.00252.2017 pubmed publisher
    We tested the hypothesis that hypoxia/reoxygenation (H/R) augments vasoreactivity to angiotensin II (Ang II)...
  56. Patel J, Sosin M, Gunarathne A, Hussain I, Davis R, Hughes E, et al. Elevated angiogenin levels in chronic heart failure. Ann Med. 2008;40:474-9 pubmed publisher
    ..We tested the hypothesis that circulating angiogenin (a potent inducer of neovascularization in vivo) is higher in CHF patients compared with controls and associated ..
  57. Rizzo P, Novelli R, Rota C, Gagliardini E, Ruggiero B, Rottoli D, et al. The Role of Angiotensin II in Parietal Epithelial Cell Proliferation and Crescent Formation in Glomerular Diseases. Am J Pathol. 2017;187:2441-2450 pubmed publisher
    ..proliferation and migration of parietal epithelial cells (PECs)/progenitor cells, and that the angiotensin (ang) II/ang II type-1 (AT1) receptor pathway may participate, together with the stromal cell-derived factor-..
  58. Prieto M, Reverte V, Mamenko M, Kuczeriszka M, Veiras L, Rosales C, et al. Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice. Am J Physiol Renal Physiol. 2017;313:F1243-F1253 pubmed publisher
    Augmented intratubular angiotensin (ANG) II is a key determinant of enhanced distal Na+ reabsorption via activation of epithelial Na+ channels (ENaC) and other transporters, which leads to the development of high ..
  59. Qiao G, Xia D, Cheng Z, Zhang G. Role of Sprouty1 (Spry1) in the pathogenesis of atrial fibrosis. Pathol Res Pract. 2018;214:308-313 pubmed publisher
    ..After that, cardiac fibroblasts were treated with or without angiotensin II (Ang II)...