AMSH

Summary

Gene Symbol: AMSH
Description: STAM binding protein
Alias: AMSH, MICCAP, STAM-binding protein, associated molecule with the SH3 domain of STAM, endosome-associated ubiquitin isopeptidase
Species: human

Top Publications

  1. ncbi Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo
    Monica Agromayor
    Department of Infectious Diseases, King s College London School of Medicine at Guy s, King s College, and St Thomas Hospitals, London SE1 9RT, United Kingdom
    J Biol Chem 281:23083-91. 2006
  2. pmc JAMM: a metalloprotease-like zinc site in the proteasome and signalosome
    Xavier I Ambroggio
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    PLoS Biol 2:E2. 2004
  3. ncbi Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines
    N Tanaka
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 274:19129-35. 1999
  4. ncbi A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP
    M Kato
    Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 275:37481-7. 2000
  5. pmc Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding
    Alessia Zamborlini
    Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 103:19140-5. 2006
  6. pmc Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
    F Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    EMBO J 20:4132-42. 2001
  7. pmc MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
    Vered Maytal-Kivity
    Dept of Biology, Institute for Catalysis Science and Technology Technion Israel Institute of Technology, Israel
    BMC Biochem 3:28. 2002
  8. doi Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH
    Inez M J Meijer
    Department of Cell and Applied Biology, Faculty of Science, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Cell Signal 24:1981-8. 2012
  9. ncbi Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery
    John McCullough
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
    Curr Biol 16:160-5. 2006
  10. ncbi A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex
    Hilda T H Tsang
    Department of Medical Genetics and Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    Genomics 88:333-46. 2006

Scientific Experts

  • Ajay Kohli
  • David Komander
  • Daniel Gorman
  • Pingzhang Wang
  • James H Hurley
  • S Urbé
  • Katherine Bowers
  • Vered Maytal-Kivity
  • Zbigniew Kmiec
  • Michael J Clague
  • Masayuki Komada
  • Nieves Ibarrola
  • BRADFORD LOWELL
  • Christopher W Davies
  • Joseph K Angleson
  • DAVID STERNER
  • Maria Sierra
  • Peter M Elias
  • David E Sterner
  • MALCOLM JAMES LOW
  • Inez M J Meijer
  • Paula E Row
  • John McCullough
  • Monica Agromayor
  • Chittaranjan Das
  • Michelle H Wright
  • Jeroen E M van Leeuwen
  • Julianna Solomons
  • Masanao Kyuuma
  • Nobuyuki Tanaka
  • Kazuo Sugamura
  • K Sugamura
  • Naomi Kitamura
  • Emi Mizuno
  • Laura M McDonell
  • Mark A Nakasone
  • Fangtian Huang
  • Jamie L Arnst
  • Everardus J J van Zoelen
  • Walter van Rotterdam
  • LAKE N PAUL
  • Anja Lange
  • Masayuki Onishi
  • Kazu Kikuchi
  • Annemarie Meenhuis
  • Carl Procko
  • Shunya Suzuki
  • H Asao
  • Piers D Nash
  • Maria I Sierra
  • Anja Bremm
  • Steven P Gygi
  • Winfried Weissenhorn
  • Burcu Hasdemir
  • James N Hislop
  • N Tanaka
  • Heinrich Gottlinger
  • Yoshiko Usami
  • Akiko Mukai
  • Suman Lata
  • Yusuke Sato
  • Juan Martin-Serrano
  • Heinrich G Gottlinger
  • Alma P Reyes-Ibarra
  • Tomoko Iwaki
  • Kaoru Kobayashi
  • Yu May Ma
  • Husam A J Alwan
  • Robert E Dejournett
  • Margarita Valadez-Sánchez
  • Christopher M Sanderson
  • Jose Vazquez-Prado
  • Akitsugu Yamamoto
  • Guadalupe Reyes-Cruz
  • Stanislav Volik
  • Michihiko Nakamura
  • Alessia Zamborlini
  • Hilda T H Tsang
  • Francisco Herrera-Vigenor
  • Man Su Kim
  • N Ishii
  • Peter Azmi
  • Kaoru Takegawa
  • Yasuhisa Fukui
  • Arun Seth
  • K Endo
  • T Takeshita
  • Haoxia Li
  • Xavier I Ambroggio
  • H Kasai

Detail Information

Publications66

  1. ncbi Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo
    Monica Agromayor
    Department of Infectious Diseases, King s College London School of Medicine at Guy s, King s College, and St Thomas Hospitals, London SE1 9RT, United Kingdom
    J Biol Chem 281:23083-91. 2006
    ..Here we report the interaction of AMSH (associated molecule with the SH3 domain of STAM), an endosomal deubiquitinating enzyme, with the endodomal sorting complex required for ..
  2. pmc JAMM: a metalloprotease-like zinc site in the proteasome and signalosome
    Xavier I Ambroggio
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    PLoS Biol 2:E2. 2004
    ..The active site-like architecture specified by the JAMM motif motivates structure-based approaches to the study of JAMM domain proteins and the development of therapeutic proteasome and signalosome inhibitors...
  3. ncbi Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines
    N Tanaka
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 274:19129-35. 1999
    ..cloned a novel molecule interacting with the SH3 domain of STAM, which was named AMSH (associated molecule with the SH3 domain of STAM)...
  4. ncbi A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP
    M Kato
    Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 275:37481-7. 2000
    ..Ubiquitination of growth factor receptors is thought to regulate their intracellular degradation. Thus, UBPY may play a regulatory role in the degradation by interaction with the SH3 domain of Hbp via the novel SH3-binding motif...
  5. pmc Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding
    Alessia Zamborlini
    Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 103:19140-5. 2006
    ..The acidic half of CHMP3 also interacts with the endosome-associated ubiquitin isopeptidase AMSH, and the coexpression of AMSH or its CHMP3-binding domain converts wild-type CHMP3 into a potent inhibitor of HIV-1 ..
  6. pmc Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
    F Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    EMBO J 20:4132-42. 2001
    ..Here we report the identification of a cytoplasmic protein, previously termed associated molecule with the SH3 domain of STAM (AMSH), as a direct binding partner for Smad6...
  7. pmc MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
    Vered Maytal-Kivity
    Dept of Biology, Institute for Catalysis Science and Technology Technion Israel Institute of Technology, Israel
    BMC Biochem 3:28. 2002
    ..In particular Rpn11, a lid subunit, serves as the paradigm for MPN-containing proteins as it is highly conserved and important for proteasome function...
  8. doi Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH
    Inez M J Meijer
    Department of Cell and Applied Biology, Faculty of Science, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Cell Signal 24:1981-8. 2012
    ..EGFR and the EGFR-ErbB2 chimera is associated with tyrosine phosphorylation of the ESCRT-0 complex subunit Hrs and AMSH-mediated deubiquitination...
  9. ncbi Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery
    John McCullough
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
    Curr Biol 16:160-5. 2006
    b>AMSH is an endosomal ubiquitin isopeptidase that can limit EGF receptor downregulation . It directly binds to the SH3 domain of STAM, which is constitutively associated with Hrs, a component of clathrin-coated structures on endosomes...
  10. ncbi A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex
    Hilda T H Tsang
    Department of Medical Genetics and Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    Genomics 88:333-46. 2006
    ..In particular, we show that two further MIT domain-containing proteins (AMSH/STAMBP and LOC129531) interact with multiple components of the human ESCRT III complex.
  11. pmc Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
    David Komander
    Division of Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    EMBO Rep 10:466-73. 2009
    ..Our results highlight remarkable specificity determinants within the ubiquitin system...
  12. pmc Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
    Anja Bremm
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nat Struct Mol Biol 17:939-47. 2010
    ..Our data highlight the intrinsic specificity of the ubiquitin system that extends to Lys11-linked chains and emphasize that differentially linked polyubiquitin chains must be regarded as independent post-translational modifications...
  13. ncbi RNF11 is a multifunctional modulator of growth factor receptor signalling and transcriptional regulation
    Peter Azmi
    Department of Anatomic Pathology and Division of Molecular and Cellular Biology, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Eur J Cancer 41:2549-60. 2005
    ..Furthermore, RNF11 is capable of degrading AMSH, a positive regulator of both TGFbeta and EGFR signalling pathways...
  14. doi Competitive binding of UBPY and ubiquitin to the STAM2 SH3 domain revealed by NMR
    Anja Lange
    Universite de Lyon, Universite Claude Bernard Lyon1, CNRS, UMR 5280 Institut des Sciences Analytiques, Villeurbanne, France
    FEBS Lett 586:3379-84. 2012
    ..domains, while the SH3 domain of STAM2 was reported to interact with deubiquitinating enzymes (DUBs) like UBPY and AMSH. In the present study, NMR evidences the interaction of the STAM2 SH3 domain with ubiquitin, demonstrating that SH3 ..
  15. doi Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively
    Inez M J Meijer
    Department of Cell and Applied Biology, Faculty of Science, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Cell Signal 25:470-8. 2013
    ..ligand-induced K63-polyubiquitination, it is not subjected to deubiquitination by the K63 polyubiquitin-specific AMSH deubiquitinating enzyme, while CYT-1 is slightly deubiquitinated by USP8...
  16. doi Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome
    Laura M McDonell
    Children s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Nat Genet 45:556-62. 2013
    ..the deubiquitinating (DUB) isopeptidase STAMBP (STAM-binding protein, also known as AMSH, associated molecule with the SH3 domain of STAM) that has a key role in cell surface receptor-mediated endocytosis and sorting...
  17. doi Mechanism of recruitment and activation of the endosome-associated deubiquitinase AMSH
    Christopher W Davies
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States
    Biochemistry 52:7818-29. 2013
    b>AMSH, a deubiquitinating enzyme (DUB) with exquisite specificity for Lys63-linked polyubiquitin chains, is an endosome-associated DUB that regulates sorting of activated cell-surface signaling receptors to the lysosome, a process mediated ..
  18. pmc Lysine 63-linked polyubiquitination is required for EGF receptor degradation
    Fangtian Huang
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
    Proc Natl Acad Sci U S A 110:15722-7. 2013
    ..and post-endocytic sorting of EGFR, a chimeric protein, in which the K63 linkage-specific deubiquitination enzyme AMSH [associated molecule with the Src homology 3 domain of signal transducing adaptor molecule (STAM)] was fused to the ..
  19. pmc Mixed-linkage ubiquitin chains send mixed messages
    Mark A Nakasone
    Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA
    Structure 21:727-40. 2013
    ..Finally, we propose a new, comprehensive notation for Ub and Ub-like polymers...
  20. pmc High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity
    Jamie L Arnst
    Eppley Institute for Cancer Research and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Anal Biochem 440:71-7. 2013
    ..The DUB AMSH (associated molecule with the SH3 domain of STAM) has been shown to be involved in regulating the ubiquitin-dependent down-regulation of ..
  21. doi Root proteases: reinforced links between nitrogen uptake and mobilization and drought tolerance
    Ajay Kohli
    Plant Breeding, Genetics, and Biotechnology Division, International Rice Research Institute, DAPO, Metro Manila, Philippines
    Physiol Plant 145:165-79. 2012
    ..rice roots, as known from rice expression databases, are discussed for future research on certain M50, Deg, FtsH, AMSH and deubiquitination proteases...
  22. pmc Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes
    James N Hislop
    Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
    J Biol Chem 284:19361-70. 2009
    ..regulation required direct ubiquitination of receptors and was also regulated by two deubiquitinating enzymes, AMSH and UBPY, which localized to late endosome/lysosome membranes containing internalized delta-opioid receptor...
  23. pmc Essential role of hIST1 in cytokinesis
    Monica Agromayor
    Department of Infectious Diseases, King s College London School of Medicine, London, United Kingdom
    Mol Biol Cell 20:1374-87. 2009
    ..that is necessary for its interaction with VPS4, LIP5 and other MIT domain-containing proteins, namely, MITD1, AMSH, UBPY, and Spastin...
  24. ncbi Empire, internationalism, and the campaign against the traffic in women and children in the 1920s
    Daniel Gorman
    20 Century Br Hist 19:186-216. 2008
    ..campaign was conducted by social relief organizations such as the Association for Moral and Social Hygiene (AMSH) and the International Bureau for the Suppression of the Traffic in Women and Children (IBSTWC)...
  25. doi Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
    Yusuke Sato
    Structural Biology Laboratory, Life Science Division, Synchrotron Radiation Research Organization and Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    Nature 455:358-62. 2008
    ..The Zn(2+)-dependent DUBs AMSH and AMSH-LP regulate receptor trafficking by specifically cleaving Lys 63-linked polyubiquitin chains from ..
  26. ncbi Controlling receptor downregulation by ubiquitination and deubiquitination
    Masayuki Komada
    Department of Biological Sciences, Tokyo Institute of Technology, 4259 B 16 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Curr Drug Discov Technol 5:78-84. 2008
    ..UBPY and AMSH in mammals, as well as Doa4 in yeast, are deubiquitinating enzymes (DUBs) that associate with class E Vps proteins ..
  27. pmc Structural basis for autoinhibition of ESCRT-III CHMP3
    Suman Lata
    Unit for Virus Host Cell Interaction, UMR 5233 UJF EMBL CNRS, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France
    J Mol Biol 378:818-27. 2008
    ..Both the closed and open conformations of CHMP3 interact with AMSH with high affinity...
  28. pmc Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2
    Burcu Hasdemir
    Department of Surgery, University of California, San Francisco, California 94143 0660, USA
    J Biol Chem 284:28453-66. 2009
    ..deubiquitination occurs between early endosomes and lysosomes and involves the endosomal deubiquitinating proteases AMSH and UBPY...
  29. pmc Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site
    Pingzhang Wang
    Chinese National Human Genome Center, 3 707 North YongChang Road BDA, Beijing, PR China
    BMC Genomics 10:518. 2009
    ..This bias leaves a large space to discover novel transcript variants...
  30. pmc AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4
    Maria I Sierra
    Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:13990-4004. 2010
    ..The deubiquitinating enzyme AMSH has been implicated in the endocytic sorting of both G protein-coupled receptors and receptor-tyrosine kinases...
  31. pmc Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76
    Maria Harkiolaki
    Cancer Research UK Cell Signalling Group and Weatherall Institute of Molecular Medicine, Oxford, UK
    EMBO J 22:2571-82. 2003
    ..Interestingly, the SH3C displays ion-dependent dimerization in the crystal and in solution, suggesting a novel mechanism for the regulation of SH3 domain functions...
  32. pmc Structural and thermodynamic comparison of the catalytic domain of AMSH and AMSH-LP: nearly identical fold but different stability
    Christopher W Davies
    Brown Laboratory of Chemistry, Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    J Mol Biol 413:416-29. 2011
    b>AMSH plays a critical role in the ESCRT (endosomal sorting complexes required for transport) machinery, which facilitates the down-regulation and degradation of cell-surface receptors...
  33. pmc Structural basis for ESCRT-III CHMP3 recruitment of AMSH
    Julianna Solomons
    Unit of Virus Host Cell Interactions UVHCI UMI 3265 Université Joseph Fourier EMBL CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
    Structure 19:1149-59. 2011
    ..We present the crystal structure of an N-terminal fragment of the deubiquitinating enzyme AMSH (AMSHΔC) in complex with the C-terminal region of ESCRT-III CHMP3 (CHMP3ΔN)...
  34. pmc Nipped in the bud: how the AMSH MIT domain helps deubiquitinate lysosome-bound cargo
    James H Hurley
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 19:1033-5. 2011
    Recruitment of the K63-linkage specific deubiquitinating enzyme AMSH is an important step in ESCRT-dependent membrane protein sorting. In this issue of Structure, Solomons et al...
  35. doi AMSH is required to degrade ubiquitinated proteins in the central nervous system
    Shunya Suzuki
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 408:582-8. 2011
    ..AMSH (associated molecule with the SH3 domain of STAM) is a deubiquitination enzyme that participates in the endosomal sorting of several cell-..
  36. doi Regulation of endocytic sorting by ESCRT-DUB-mediated deubiquitination
    Michelle H Wright
    Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Cell Biochem Biophys 60:39-46. 2011
    ..Two dubiquitinating enzymes--ubiquitin-specific protease 8 (USP8/Ubpy) and associated molecule with the SH3 domain of STAM (AMSH)--interact with ESCRT components to modulate the ubiquitination status of receptors and ..
  37. pmc Glia delimit shape changes of sensory neuron receptive endings in C. elegans
    Carl Procko
    Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065 USA
    Development 138:1371-81. 2011
    ..endings of the AWC neurons in dauers remodel in the confines of a compartment defined by the amphid sheath (AMsh) glial cell that envelops these endings...
  38. doi The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor
    Annemarie Meenhuis
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Biochem J 434:343-51. 2011
    ..Two of these enzymes, AMSH [associated molecule with the SH3 domain of STAM (signal transducing adaptor molecule)] and UBPY (ubiquitin isopeptidase Y), interact with the ..
  39. doi Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis
    Akiko Mukai
    Department of Biological Sciences, Tokyo Institute of Technology, 4259 B 16 Nagatsuta, Yokohama 226 8501, Japan
    J Cell Sci 121:1325-33. 2008
    ..Two deubiquitylating enzymes UBPY and AMSH, which act on endosomes in interphase, were also recruited to the cleavage region...
  40. ncbi The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation
    Paula E Row
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, LiverpoolL693BX, United Kingdom
    J Biol Chem 282:30929-37. 2007
    ..In common with other MIT-containing proteins such as AMSH and VPS4, UBPY can interact with CHMP proteins, which are known to regulate endosomal sorting of ubiquitinated ..
  41. ncbi The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation
    Paula E Row
    Physiological Laboratory, University of Liverpool, Crown Street, L69 3BX Liverpool, United Kingdom
    J Biol Chem 281:12618-24. 2006
    ..The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM.
  42. pmc Decoding the fine-scale structure of a breast cancer genome and transcriptome
    Stanislav Volik
    Department of Urology, and Cancer Research Institute, University of California San Francisco Comprehensive Cancer Center, San Francisco, California 94115, USA
    Genome Res 16:394-404. 2006
    ..Given these properties, ESP could play an important role in a tumor genome project...
  43. ncbi Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII
    Katherine Bowers
    Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 281:5094-105. 2006
    ..We also show that depletion of the deubiquitinating enzymes AMSH (associated molecule with the SH3 domain of STAM (signal transducing adaptor molecule)) and UBPY (ubiquitin isopeptidase Y) have opposite ..
  44. pmc Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT
    H Asada
    Department of Microbiology and Immunology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Exp Med 189:1383-90. 1999
    ..Our data suggest that Grf40 is an adaptor molecule involved in TCR-mediated signaling through a more efficient interaction than Grb2 with SLP-76 and LAT...
  45. pmc AMSH is an endosome-associated ubiquitin isopeptidase
    John McCullough
    Physiological Laboratory, University of Liverpool, Crown St, Liverpool, L69 3BX, UK
    J Cell Biol 166:487-92. 2004
    ..We have looked for similar activity in associated molecule with the SH3 domain of STAM (AMSH), a JAMM domain-containing protein that associates with the SH3-domain of STAM, a ..
  46. ncbi An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein
    Haoxia Li
    Molecular and Cellular Biology Research
    Oncogene 23:1801-8. 2004
    ..Among 18 in-frame positive clones, three were found to be ZBRK1, Eps15 and AMSH (associated molecule with the SH3 domain of STAM)...
  47. pmc Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling
    Nieves Ibarrola
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Cell Biol 5:2. 2004
    ..Signaling by these factors is mediated chiefly by the Smad family of latent transcription factors...
  48. ncbi Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe
    Masayuki Onishi
    Laboratory of Biological Chemistry, Graduate School of Agricultural and Life Science, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    Biosci Biotechnol Biochem 67:1772-9. 2003
    ..They included genes coding for proteins with domains homologous to calcium transporters, casein kinase II, UBC13, AMSH, Vps23p, and Vps27p of Saccharomyces cerevisiae...
  49. ncbi A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells
    Keiko Kitajima
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 309:135-42. 2003
    Associated Molecule with SH3 domain of STAM (AMSH) plays a critical role in the cytokine-mediated intracellular signal transduction downstream of the Jak2/Jak3-STAM complex...
  50. ncbi Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif
    Kazu Kikuchi
    Department of Immunology and Microbiology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575, Sendai, Japan
    Biochem Biophys Res Commun 306:637-43. 2003
    We have isolated a cDNA clone encoding a new AMSH (associated molecule with the SH3 domain of STAM) family protein, termed AMSH-like protein (AMSH-LP)...
  51. ncbi A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling
    Donna M Berry
    The Arthur and Sonia Labatt, Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, M5G1X8, Ontario, Canada
    Curr Biol 12:1336-41. 2002
    ..These results provide a molecular explanation for the specific role of Gads in T cell receptor signaling, and identify a discrete subclass of SH3 domains whose binding is dependent on a core R-X-X-K motif...
  52. pmc Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice
    N Ishii
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Mol Cell Biol 21:8626-37. 2001
    b>AMSH, a molecule that associates with STAM1, is involved in the in vitro cell growth signaling mediated by interleukin 2 and granulocyte-macrophage colony-stimulating factor...
  53. ncbi Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes
    Michihiko Nakamura
    Department of Biological Sciences, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Genes Cells 11:593-606. 2006
    ..b>AMSH is a deubiquitinating enzyme that interacts with STAM and is implicated in the down-regulation of epidermal growth ..
  54. pmc Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe
    Tomoko Iwaki
    Department of Life Sciences, Faculty of Agriculture, Kagawa University, Kagawa 761 0795, Japan
    Microbiology 153:2753-64. 2007
    ..Sch. pombe has a mammalian AMSH homologue, sst2. Phenotypic analyses suggested that Sst2p is a class E Vps protein...
  55. ncbi Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism
    Alma P Reyes-Ibarra
    Centro de Investigación y de Estudios Avanzados Instituto Politécnico Nacional, Cell Biology Department, Mexico DF, Mexico
    Mol Endocrinol 21:1394-407. 2007
    ..In addition, AMSH (associated molecule with the SH3 domain of STAM), a CaR carboxyl-terminal binding protein, redirects CaR from slow recycling to down-..
  56. ncbi Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation
    Yu May Ma
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:9805-12. 2007
    ..Here we report that CHMP3, an ESCRT-III complex component, and associated molecule of SH3 domain of STAM (AMSH), a deubiquitinating enzyme, interact with each other in cells...
  57. ncbi Central regulation of food intake in ageing
    Z Kmiec
    Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 57:7-16. 2006
    ..ageing does not significantly alter hypothalamic mRNA levels of important anorexigens such as CART and aMSH. The presented findings suggest that, at least in rodents, ageing is associated with the general down-regulation of ..
  58. ncbi AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes
    Masanao Kyuuma
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Seiryo machi, Sendai, 980 8575 Japan
    Cell Struct Funct 31:159-72. 2007
    ..Ubiquitinated cargo is targeted to endosomes and digested by lysosomal enzymes. We previously identified AMSH, a deubiquitination enzyme (DUB), to be involved in vesicular transport...
  59. ncbi UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation
    Husam A J Alwan
    Department of Cell Biology, Institute for Neuroscience, Faculty of Natural Sciences, Mathematics and Informatics, Radboud University Nijmegen, 6525 ED Nijmegen, The Netherlands
    J Biol Chem 282:1658-69. 2007
    ..The role of the de-ubiquitinating enzymes AMSH and UBPY in endosomal trafficking of cargo proteins such as the epidermal growth factor receptor (EGFR) has only ..
  60. ncbi STAM-AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH
    Man Su Kim
    Biomedical Research Center, Korea Institute of Science and Technology, Seongbuk gu, Seoul 136 791, South Korea
    Biochem Biophys Res Commun 351:612-8. 2006
    ..Associated molecule with SH3 domain of STAM (AMSH), a zinc-containing ubiquitin isopeptidase, is thought to play a role in regulation of ubiquitin-mediated ..
  61. ncbi Control of growth factor receptor dynamics by reversible ubiquitination
    S Urbé
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, UK
    Biochem Soc Trans 34:754-6. 2006
    ..We have characterized two de-ubiquitinating enzymes that interact with components of this machinery. AMSH [associated molecule with the SH3 domain (Src homology 3 domain) of STAM (signal transducing adapter molecule)] ..
  62. ncbi Endocytosis: the DUB version
    Michael J Clague
    Physiological Laboratory, School of Biomedical Sciences, Crown Street, Liverpool, L69 3BX, UK
    Trends Cell Biol 16:551-9. 2006
    ..Two deubiquitinating enzymes, AMSH and UBPY, interact with ESCRT protein components but exert opposite effects upon the rate of epidermal growth ..
  63. pmc Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteins
    Robert E Dejournett
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 019, Houston, TX 77030, USA
    Biochem J 401:521-31. 2007
    ..The deubiquitinase AMSH (associated molecule with the SH3 domain of signal transducing adaptor molecule) specifically interacts with ..
  64. ncbi AMSH regulates calcium-sensing receptor signaling through direct interactions
    Francisco Herrera-Vigenor
    Department of Cell Biology, CINVESTAV IPN Apartado postal 14 740, Mexico DF 07000, Mexico
    Biochem Biophys Res Commun 347:924-30. 2006
    ..We identified AMSH, an ubiquitin isopeptidase, as a CaR-interacting partner...
  65. ncbi A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes
    Emi Mizuno
    Department of Biological Sciences, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Traffic 7:1017-31. 2006
    ..protein complex essential for the initial step of the sorting pathway, binds two deubiquitinating enzymes, UBPY and AMSH. Here we examined the effects of inactivating UBPY on protein ubiquitination at endosomes...
  66. ncbi STAM2, a new member of the STAM family, binding to the Janus kinases
    K Endo
    Department of Microbiology, Tohoku University School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai 980 8575, Japan
    FEBS Lett 477:55-61. 2000
    ....

Research Grants9

  1. Melanocyte-Keratinocyte Cross-Talk In Relation To Barrier Function
    Peter M Elias; Fiscal Year: 2010
    ..to either increase epidermal pigmentation by increasing epidermal POMC expression and proteolytic processing to aMSH, and/or MC1R signalling of melanocyte function...
  2. Molecular screen for isopeptidase inhibitors to treat pulmonary disease
    DAVID STERNER; Fiscal Year: 2007
    b>AMSH is a recently described ubiquitin isopeptidase that is associated with endosomal trafficking of the human epithelial growth factor receptor (EGFR)...
  3. Proopiomelanocortin gene expression and obesity
    MALCOLM JAMES LOW; Fiscal Year: 2010
    ..of neurons located in the hypothalamus and medulla that express the Pomc gene and synthesize the neuropeptides aMSH and bEndorphin from the precursor protein, proopiomelanocortin (POMC)...