AMPK

Summary

Gene Symbol: AMPK
Description: protein kinase AMP-activated non-catalytic subunit beta 1
Alias: AMPK, HAMPKb, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase beta-1 subunit, AMP-activated protein kinase beta subunit, AMPK beta -1 chain, AMPK beta 1, AMPK subunit beta-1, AMPKb, protein kinase, AMP-activated, beta 1 non-catalytic subunit, protein kinase, AMP-activated, noncatalytic, beta-1
Species: human
Products:     AMPK

Top Publications

  1. Iseli T, Oakhill J, Bailey M, Wee S, Walter M, van Denderen B, et al. AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267. J Biol Chem. 2008;283:4799-807 pubmed
    AMP-activated protein kinase (AMPK) plays multiple roles in the body's overall metabolic balance and response to exercise, nutritional stress, hormonal stimulation, and the glucose-lowering drugs metformin and rosiglitazone...
  2. Dyck J, Gao G, Widmer J, Stapleton D, Fernandez C, Kemp B, et al. Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits. J Biol Chem. 1996;271:17798-803 pubmed
  3. Carling D. The AMP-activated protein kinase cascade--a unifying system for energy control. Trends Biochem Sci. 2004;29:18-24 pubmed
    AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that acts as an intracellular energy sensor maintaining the energy balance within the cell...
  4. Inoki K, Zhu T, Guan K. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003;115:577-90 pubmed
    ..Under energy starvation conditions, the AMP-activated protein kinase (AMPK) phosphorylates TSC2 and enhances its activity...
  5. Shaw R, Kosmatka M, Bardeesy N, Hurley R, Witters L, Depinho R, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004;101:3329-35 pubmed
    AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP ratio...
  6. Solaz Fuster M, Gimeno Alcañiz J, Casado M, Sanz P. TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. Cell Signal. 2006;18:1702-12 pubmed
    AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy charge...
  7. Stahmann N, Woods A, Carling D, Heller R. Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta. Mol Cell Biol. 2006;26:5933-45 pubmed
    AMP-activated protein kinase (AMPK) is a sensor of cellular energy state in response to metabolic stress and other regulatory signals...
  8. Dowling R, Zakikhani M, Fantus I, Pollak M, Sonenberg N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res. 2007;67:10804-12 pubmed
    ..The effects of metformin are explained by the activation of AMP-activated protein kinase (AMPK), which regulates cellular energy metabolism...
  9. Kahn B, Alquier T, Carling D, Hardie D. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005;1:15-25 pubmed
    The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status, and recent data demonstrate that it also plays a critical role in systemic energy balance...

More Information

Publications124 found, 100 shown here

  1. Viana R, Aguado C, Esteban I, Moreno D, Viollet B, Knecht E, et al. Role of AMP-activated protein kinase in autophagy and proteasome function. Biochem Biophys Res Commun. 2008;369:964-8 pubmed publisher
    ..We have found that AICAR, a known activator of AMPK, has a dual effect...
  2. Foller M, Sopjani M, Koka S, Gu S, Mahmud H, Wang K, et al. Regulation of erythrocyte survival by AMP-activated protein kinase. FASEB J. 2009;23:1072-80 pubmed publisher
    AMP-activated protein kinase (AMPK), an energy-sensing enzyme, counteracts energy depletion by stimulation of energy production and limitation of energy utilization...
  3. Mihaylova M, Shaw R. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011;13:1016-23 pubmed publisher
    One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases...
  4. Li C, Liu V, Chiu P, Chan D, Ngan H. Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications. BMC Cancer. 2012;12:357 pubmed publisher
    AMP-activated protein kinase (AMPK) has recently been considered as a potential target for cancer therapy. However, the expression status of various subunits of the heterotrimeric AMPK in human cancers is rarely reported...
  5. Greer E, Oskoui P, Banko M, Maniar J, Gygi M, Gygi S, et al. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem. 2007;282:30107-19 pubmed
    ..The AMP-activated protein kinase (AMPK) plays a critical role in the cellular responses to low energy levels by switching off energy-consuming pathways ..
  6. Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, et al. Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. 2008;27:1537-48 pubmed publisher
    ..The AMP-activated protein kinase (AMPK), consisting of catalytic alpha subunit and regulatory subunits beta and gamma, has a pivotal function in energy ..
  7. Thornton C, Sardini A, Carling D. Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression. J Biol Chem. 2008;283:17116-22 pubmed publisher
    AMP-activated protein kinase (AMPK) plays a crucial role in both cellular and whole body energy homeostasis...
  8. Gwinn D, Shackelford D, Egan D, Mihaylova M, Mery A, Vasquez D, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008;30:214-26 pubmed publisher
    b>AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP...
  9. Thornton C, Snowden M, Carling D. Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J Biol Chem. 1998;273:12443-50 pubmed
    The AMP-activated protein kinase (AMPK) is a member of a growing family of related kinases, including the SNF1 complex in yeast, which respond to nutritional stress...
  10. Wang C, Yen J, Cheng Y, Lin C, Hsieh C, Gau R, et al. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet-induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles. Food Nutr Res. 2017;61:1379861 pubmed publisher
    ..b>Abbreviations: Abcg5: ATP-binding cassette subfamily G member 5; ALT: alanine aminotransferase; AMPK: adenosine monophosphate-activated protein kinase; AST: aspartate aminotransferase; B/F: Bacteroidetes to ..
  11. Dinda B, Dinda M, Kulsi G, Chakraborty A, Dinda S. Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. Eur J Med Chem. 2019;169:185-199 pubmed publisher
    ..proteins, Bcl-2 via activations of growth-related protein-1 receptor (GLP-1R), PKC, MEK, MAPK/PI3K, and AMPK, and suppressed the expressions of pro-apoptotic proteins, Bax and caspase-3...
  12. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..as a compensatory adaptation to the energetic deficits in mitochondrial diseases are described (PGC- 1, Sirtuins, AMPK)...
  13. Engin A. Human Protein Kinases and Obesity. Adv Exp Med Biol. 2017;960:111-134 pubmed publisher
    ..Like adenosine monophosphate (AMP)-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR), N-terminal Per-ARNT-Sim (PAS) kinase are nutrient responsive protein ..
  14. Zhao Z, Barcus M, Kim J, Lum K, Mills C, Lei X. High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs. J Nutr. 2016;146:1625-33 pubmed publisher
    ..P70), and phosphorylated ribosomal protein S6 (P-S6); 88-105%], energy metabolism [AMP-activated protein kinase (AMPK); up to 2.8-fold], and selenoprotein glutathione peroxidase 3 (GPX3; 1.4-fold) and suppressed (P < 0...
  15. Panossian A, Seo E, Efferth T. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine. 2018;50:257-284 pubmed publisher
    ..melatonin, nitric oxide synthase, GP6, Gαs, MAPK, neuroinflammation, neuropathic pain, opioids, renin-angiotensin, AMPK, calcium, and synapses; and pathways associated with dendritic cell maturation and G-coupled protein receptor-..
  16. Xie W, Zhou P, Sun Y, Meng X, Dai Z, Sun G, et al. Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies. Cells. 2018;7: pubmed publisher
    ..ATP levels, the blood-brain barrier and other effects via N-methyl-D-aspartic acid (NMDA) receptors, ERS, and AMP/AMPK-GLUT pathways...
  17. Park S, Sung Y, Jang S, Nho K, Choi G, Kim H. The Korean herbal medicine, Do In Seung Gi-Tang, attenuates atherosclerosis via AMPK in high-fat diet-induced ApoE(-/-) mice. BMC Complement Altern Med. 2016;16:352 pubmed publisher
    ..molecule-1 [VCAM-1], and E-selectin), fatty acid synthase (FAS), adenosine monophosphate-activated protein kinase (AMPK), and acetyl-coA carboxylase (ACC) in the aorta or liver tissues was measured by western blot analysis...
  18. Lv H, Hong L, Tian Y, Yin C, Zhu C, Feng H. Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway. Cell Commun Signal. 2019;17:2 pubmed publisher
    ..Moreover, Cori clearly induced the phosphorylation of AMP-activated protein kinase (AMPK), glycogen synthase kinase-3β (GSK3β), liver kinase B1 (LKB1) and acetyl-CoA carboxylase (ACC)...
  19. Luo L, Li J, Liu H, Jian X, Zou Q, Zhao Q, et al. Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts. Int J Mol Sci. 2017;18: pubmed publisher
    ..Phosphorylation of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase-protein kinase (PI3K-Akt) were examined ..
  20. Bao L, Hu L, Zhang Y, Wang Y. Hypolipidemic effects of flavonoids extracted from Lomatogonium rotatum. Exp Ther Med. 2016;11:1417-1424 pubmed
    ..a reverse transcription polymerase chain reaction; whereas FAS, adenosine monophosphate-activated protein kinase (AMPK) and threonine-172 phosphorylated AMPK protein levels were detected by western blotting...
  21. Krakauer T. Inflammasome, mTORC1 activation, and metabolic derangement contribute to the susceptibility of diabetics to infections. Med Hypotheses. 2015;85:997-1001 pubmed publisher
    ..switches cell metabolism from oxidative phosphorylation to glycolysis and deactivates AMP-activated protein kinase (AMPK), a critical sensor of nutrient and cellular energy, leading to mTORC1 activation...
  22. Naowaboot J, Wannasiri S, Pannangpetch P. Vernonia cinerea water extract improves insulin resistance in high-fat diet-induced obese mice. Nutr Res. 2018;56:51-60 pubmed publisher
    ..mice by modulating both phosphatidylinositol-3-kinase (PI3K) and adenosine monophosphate-activated protein kinase (AMPK) pathways in liver, skeletal muscle, and adipose tissue...
  23. Shi H, Xu C, Liu M, Wang B, Liu W, Chen D, et al. Resveratrol Improves the Energy Sensing and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK-SIRT1-PGC-1α Network. Front Physiol. 2018;9:1258 pubmed publisher
    ..to the control group, whereas the opposite was found for protein levels of AMP-activated protein kinase α (t-AMPKα), phosphorylated AMP-activated protein kinase α (p-AMPKα), sirtuin-1 (SIRT1), and p-AMPKα/t-AMPKα ratio as ..
  24. Nguyen P, GREENE E, Ishola P, Huff G, Donoghue A, Bottje W, et al. Chronic Mild Cold Conditioning Modulates the Expression of Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and Improves Growth Performances in Young Chicks. PLoS ONE. 2015;10:e0142319 pubmed publisher
    ..Compared to the control condition, CMCC increased the mRNA abundance of AMPKα1/α2 and decreased mTOR gene expression (P<0.05), the master energy and nutrient sensors, respectively...
  25. Hsu J, Lin H, Hsu C, Chen B, Chen J. Aqueous Extract of Pepino (Solanum muriactum Ait) Leaves Ameliorate Lipid Accumulation and Oxidative Stress in Alcoholic Fatty Liver Disease. Nutrients. 2018;10: pubmed publisher
    ..effect of AEPL might be mediated via inducing hepatic levels of phospho-adenosine monophosphate-activated kinase (p-AMPK) and peroxisome proliferator-activated receptor (PPAR)-α, and reducing the expressions of hepatic lipogenic ..
  26. Engin A, Engin A. The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity. Adv Exp Med Biol. 2017;960:511-527 pubmed publisher
    ..nitric oxide synthase (iNOS) and dissociation of endothelial adenosine monophosphate activated protein kinase (AMPK)- phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt)- endothelial NO synthase (eNOS) pathway enhances ..
  27. Choi S, Lim J, Kim M, Kim E, Kim Y, Choi B, et al. Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy. Metabolism. 2018;85:348-360 pubmed publisher
    ..Consistent up-regulation of phospho-Thr172 AMP-dependent kinase (AMPK), peroxisome proliferative-activated receptor α (PPARα), phospho-Thr473 Akt, phospho-Ser79..
  28. Chen H, Tsai T, Tsai Y, Liao J, Yen C, Chen C. Kefir peptides prevent high-fructose corn syrup-induced non-alcoholic fatty liver disease in a murine model by modulation of inflammation and the JAK2 signaling pathway. Nutr Diabetes. 2016;6:e237 pubmed publisher
    ..In addition, kefir peptides markedly increased phosphorylation of AMPK to downregulate its targeted enzymes, ACC (acetyl-CoA carboxylase) and SREBP-1c (sterol regulatory element-binding ..
  29. Ha J, Guan K, Kim J. AMPK and autophagy in glucose/glycogen metabolism. Mol Aspects Med. 2015;46:46-62 pubmed publisher
    ..AMP-activated protein kinase (AMPK) has been appreciated for many years as a central metabolic regulator to inhibit energy-consuming pathways as well ..
  30. Greig F, Ewart M, McNaughton E, Cooney J, Spickett C, Kennedy S. The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascul Pharmacol. 2015;74:93-102 pubmed publisher
    AMP-activated protein kinase (AMPK) is present in the arterial wall and is activated in response to cellular stressors that raise AMP relative to ADP/ATP...
  31. Craps J, Joris V, De Jongh B, Sonveaux P, Horman S, Lengele B, et al. Involvement of mTOR and Regulation by AMPK in Early Iodine Deficiency-Induced Thyroid Microvascular Activation. Endocrinology. 2016;157:2545-59 pubmed publisher
    ..of mammalian target of rapamycin (mTOR) as a positive regulator of this pathway and AMP-activated protein kinase (AMPK) as a negative feedback regulator to explain the transient nature of ID-induced microvascular changes under ..
  32. Maixner D, Yan X, Hooks S, Weng H. AMPK?1 knockout enhances nociceptive behaviors and spinal glutamatergic synaptic activities via production of reactive oxygen species in the spinal dorsal horn. Neuroscience. 2016;326:158-169 pubmed publisher
    Emerging studies have shown that pharmacological activation of adenosine monophosphate-activated protein kinase (AMPK) produces potent analgesic effects in different animal pain models...
  33. Dey P, Baddour J, Muller F, Wu C, Wang H, Liao W, et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017;542:119-123 pubmed publisher
    ..These changes activate AMP activated protein kinase (AMPK), which in turn directly suppresses sterol regulatory element-binding protein 1 (SREBP1)-directed transcription of ..
  34. Abid N, Yoon G, Kim M. Molecular Cloning and Expression of Osmotin in a Baculovirus-Insect System: Purified Osmotin Mitigates Amyloid-beta Deposition in Neuronal Cells. Sci Rep. 2017;7:8147 pubmed publisher
    ..In vitro analysis of purified Osmotin protein showed excellent cell viability, p-AMPK activation and a reduction in amyloid-beta deposition...
  35. Zhong H, Liu H, Jiang Z. Genistein Ameliorates Fat Accumulation Through AMPK Activation in Fatty Acid-Induced BRL Cells. J Food Sci. 2017;82:2719-2725 pubmed publisher
    ..results displayed that genistein promoted the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) suppressed by fatty acid, which were significantly weakened by compound C, an AMPK inhibitor...
  36. Boehm M, Crawford M, Moscovitz J, Carpino P. Diabetes area patent participation analysis - Part II: Years 2011-2016. Expert Opin Ther Pat. 2017;: pubmed publisher
    ..families with the largest size counts, a metric useful in assessing patent value and applicant interest, were AMPK, CALCR, DPP4, and GLP1R...
  37. Sanchez A, Candau R, Bernardi H. AMP-activated protein kinase stabilizes FOXO3 in primary myotubes. Biochem Biophys Res Commun. 2018;499:493-498 pubmed publisher
    AMP-activated protein kinase (AMPK) is a critical enzyme in conditions of cellular energy deficit such as exercise, hypoxia or nutritional stress...
  38. Yang X, Yang J, Xu C, Huang M, Zhou Q, Lv J, et al. Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice. J Ethnopharmacol. 2015;171:161-70 pubmed publisher
    ..Phosphorylation of the AMP-activated protein kinase (AMPK) expression in liver was measured...
  39. Namgaladze D, Snodgrass R, Angioni C, Grossmann N, Dehne N, Geisslinger G, et al. AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages. J Biol Chem. 2015;290:24484-94 pubmed publisher
    ..AMP-activated protein kinase (AMPK) is a metabolic sensor/regulator that supports an anti-inflammatory macrophage phenotype...
  40. Margalha L, Valerio C, Baena Gonzalez E. Plant SnRK1 Kinases: Structure, Regulation, and Function. Exp Suppl. 2016;107:403-438 pubmed
    ..SnRK1 shares clear structural and functional similarities with its orthologs, yeast SNF1 and mammalian AMPK, but has evolved unique features that presumably provide a better adaptation to an autotrophic lifestyle...
  41. Shah A, Quon A, Morton J, Davidge S. Postnatal resveratrol supplementation improves cardiovascular function in male and female intrauterine growth restricted offspring. Physiol Rep. 2017;5: pubmed publisher
    ..Resveratrol increased cardiac phospho-adenosine monophosphate kinase (p-AMPK) levels in only female IUGR offspring. IUGR or resveratrol did not alter cardiac superoxide levels...
  42. Gao H, Zhao Q, Song Z, Yang Z, Wu Y, Tang S, et al. PGLP-1, a novel long-acting dual-function GLP-1 analog, ameliorates streptozotocin-induced hyperglycemia and inhibits body weight loss. FASEB J. 2017;31:3527-3539 pubmed publisher
    ..Additionally, PGLP-1 improved insulin sensitivity, inhibited gluconeogenesis by increasing expression of AMPK and receptor subfamily 0, group B, member 2 (SHP), and inhibited body weight loss by inhibiting ?-oxidation, ..
  43. Cervone D, Dyck D. Acylated and unacylated ghrelin do not directly stimulate glucose transport in isolated rodent skeletal muscle. Physiol Rep. 2017;5: pubmed publisher
    ..on glucose transport, ghrelin and GH also had no stimulatory effect on Ser473 AKT or Thr172 AMPK phosphorylation, two key signaling proteins involved in glucose transport...
  44. Gopoju R, Panangipalli S, Kotamraju S. Metformin treatment prevents SREBP2-mediated cholesterol uptake and improves lipid homeostasis during oxidative stress-induced atherosclerosis. Free Radic Biol Med. 2018;118:85-97 pubmed publisher
    ..of SREBP2 (SREBP2-M) during oxidative stress was associated with the inhibition of AMP-activated protein kinase (AMPK) activation...
  45. Santos Llamas A, Monte M, Marin J, Perez M. Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine. Arch Toxicol. 2018;92:2109-2118 pubmed publisher
    ..increases in autophagy inhibitors activity (AKT/mTOR), and absence of changes (Beclin-1, Atg5, Atg7) or decreases (AMPK/ULK1) in the expression/activity of pro-autophagy proteins; and (ii) reduced autophagosome degradation as indicated ..
  46. Patel V, Mori J, McLean B, Basu R, Das S, Ramprasath T, et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes. 2016;65:85-95 pubmed publisher
    ..inflammation in ACE2KO-HFD mice was associated with decreased myocardial adiponectin, decreased phosphorylation of AMPK, increased cardiac steatosis and lipotoxicity, and myocardial insulin resistance, which worsened heart function...
  47. Yao L, Wan J, Li H, Ding J, Wang Y, Wang X, et al. Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK. Reprod Biol Endocrinol. 2015;13:118 pubmed publisher
    ..Moreover, we found that RV relieved GDM symptoms through enhancing AMPK activation, which in turn reduced production and activity of glucose-6-phosphatase in both pregnant db/+ females ..
  48. Griss T, Vincent E, Egnatchik R, Chen J, Ma E, Faubert B, et al. Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis. PLoS Biol. 2015;13:e1002309 pubmed publisher
    ..Here we demonstrate that the metabolic checkpoint kinases AMP-activated protein kinase (AMPK) and LKB1 are not required for the antiproliferative effects of metformin...
  49. Audet Walsh Ã, Papadopoli D, Gravel S, Yee T, Bridon G, Caron M, et al. The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep. 2016;14:920-931 pubmed publisher
    Reprogramming of cellular metabolism plays a central role in fueling malignant transformation, and AMPK and the PGC-1α/ERRα axis are key regulators of this process...
  50. Kim E, Lim J, Kim M, Kim H, Park C, Chang Y, et al. PPAR? agonist, fenofibrate, ameliorates age-related renal injury. Exp Gerontol. 2016;81:42-50 pubmed publisher
    ..This protective effect against age-related renal injury occurred through the activation of AMPK and SIRT1 signaling...
  51. Kan J, Yen M, Wang J, Wu D, Chiu Y, Ho Y, et al. Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer. Oncotarget. 2016;7:31336-49 pubmed publisher
    ..The signaling pathway liver kinase B1(LKB1)/AMP-dependent protein kinase (AMPK)/target of rapamycin complex (TORC) 1 was involved in regulation of NUCB-2-mediated metastasis and EMT properties...
  52. Bone N, Liu Z, Pittet J, Zmijewski J. Frontline Science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin-induced ALI. J Leukoc Biol. 2017;101:357-365 pubmed publisher
    ..to endotoxin-induced ALI, a situation characterized by diminished activity of AMP-activated protein kinase (AMPK)...
  53. Eisenreich A, Leppert U. Update on the Protective Renal Effects of Metformin in Diabetic Nephropathy. Curr Med Chem. 2017;24:3397-3412 pubmed publisher
    ..of diabetic nephropathy involve amongst others the modulation of cell signaling via AMP-activated kinase (AMPK) and mammalian target of rapamycin (mTOR), reactive oxygen generation, and endoplasmic reticulum stress under ..
  54. Lin H, Li N, He H, Ying Y, Sunkara S, Luo L, et al. AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition. Mol Pharmacol. 2015;88:1062-71 pubmed publisher
    AMP-activated protein kinase (AMPK), an important downstream effector of the tumor suppressor liver kinase 1 (LKB1) and pharmacologic target of metformin, is well known to exert a preventive and inhibitory effect on tumorigenesis; however,..
  55. Liu X, Peng S, Zhao Y, Zhao T, Wang M, Luo L, et al. AMPK Negatively Regulates Peripheral Myelination via Activation of c-Jun. Mol Neurobiol. 2017;54:3554-3564 pubmed publisher
    ..Here, we show that AMP-activated protein kinase (AMPK) in sciatic nerves was gradually decreased during the PNS myelination process...
  56. Oh T, Jeon Y, Kim S, Kim E. Hypothalamic AMP-activated Protein Kinase as a Regulator of Food Intake and Energy Balance. CNS Neurol Disord Drug Targets. 2016;15:896-909 pubmed
    ..Hypothalamic AMPactivated protein kinase (AMPK) integrates diverse hormonal and nutritional signals to regulate food intake and energy metabolism...
  57. Lee D, Han D, Nam K, Park J, Kim S, Lee M, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016;99:520-532 pubmed publisher
    ..Ezetimibe activates AMP-activated protein kinase (AMPK), which in turn phosphorylates p62 (p-S351) via their direct interaction...
  58. Lee S, Jeong S, Kim W, Kim D, Yang Y, Yoon J, et al. Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase. Biochem Biophys Res Commun. 2017;483:449-455 pubmed publisher
    ..gastric carcinoma cells and macrophage cells, rebamipide induced phosphorylation of AMP-activated protein kinase (AMPK), leading to phosphorylation of acetyl-CoA carboxylase (ACC), a substrate of AMPK...
  59. Aoki Y, Ozawa T, Takemasa T, Numata O. Black Tea High-Molecular-Weight Polyphenol-Rich Fraction Promotes Hypertrophy during Functional Overload in Mice. Molecules. 2017;22: pubmed publisher
    ..extracted from black tea that stimulates training-induced 5' adenosine monophosphate-activated protein kinase (AMPK) activation and improves endurance capacity...
  60. Zhou S, Duan Y, Wang J, Zhang J, Sun H, Jiang H, et al. Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. Eur J Med Chem. 2017;140:448-464 pubmed publisher
    ..8- to 2.3-fold), reduced gluconeogenesis (60-85%), inhibited mitochondria respiratory chain complex I and activated AMPK indirectly. In a db/db mice model, compounds 4bq and 4bv lowered fasting blood glucose at a dose of 120 mg/kg/day...
  61. Yan P, Bai L, Lu W, Gao Y, Bi Y, Lv G. Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage. Iran J Basic Med Sci. 2017;20:1029-1036 pubmed publisher
    AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models...
  62. Tuazon M, Campbell S, Klein D, Shapses S, Anacker K, Anthony T, et al. Effects of ovariectomy and exercise training intensity on energy substrate and hepatic lipid metabolism, and spontaneous physical activity in mice. Metabolism. 2018;83:234-244 pubmed publisher
    ..Only HIIE increased hepatic AMPK in OVX and SHAM, but neither training type impacted VLDL-TG secretion...
  63. Choudhury M, Qadri I, Rahman S, Schroeder Gloeckler J, Janssen R, Friedman J. C/EBP? is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells. Mol Cell Endocrinol. 2011;331:102-8 pubmed publisher
    ..C/EBP? but not pCREB was suppressed by the AMPK-activator AICAR or constitutively active AMPK, while dominant negative AMPK increased C/EBP? expression...
  64. Fentz J, Kjøbsted R, Kristensen C, Hingst J, Birk J, Gudiksen A, et al. AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle. Am J Physiol Endocrinol Metab. 2015;309:E900-14 pubmed publisher
    ..Adaptations in skeletal muscle by pharmacologically induced activation of 5'-AMP-activated protein kinase (AMPK) are dependent on the AMPKα2 subunit...
  65. Wu R, Wang H, Yu H, Cui X, Xu M, Xu X, et al. Doxorubicin toxicity changes myocardial energy metabolism in rats. Chem Biol Interact. 2016;244:149-58 pubmed publisher
    ..general blood biomarkers, endogenous antioxidant enzymes, cardiac energy metabolism and related mRNA expression of AMPK signal pathway were determined...
  66. Gamberi T, Modesti A, Magherini F, D Souza D, Hawke T, Fiaschi T. Activation of autophagy by globular adiponectin is required for muscle differentiation. Biochim Biophys Acta. 2016;1863:694-702 pubmed publisher
    ..Here we demonstrate that globular adiponectin (gAd) activates autophagy in skeletal muscle myoblasts via an AMPK-dependent mechanism...
  67. Wysham W, Roque D, Han J, Zhang L, Guo H, Gehrig P, et al. Effects of Fatty Acid Synthase Inhibition by Orlistat on Proliferation of Endometrial Cancer Cell Lines. Target Oncol. 2016;11:763-769 pubmed
    ..Western immunoblotting was performed to determine changes in FAS, cellular stress, cell cycle progression, and the AMPK/mTOR pathways...
  68. Li T, Liu D, Lei X, Jiang Q. Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway. Biochem Biophys Res Commun. 2017;482:1037-1041 pubmed publisher
    ..Moreover, Par3L depletion resulted in abnormal activation of Lkb1/AMPK signaling cascade...
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    ..A logistic model based on GMPR has good ability to classify AD cases. GMPR's product GMPR1 is in the AMPK and adenosine receptor pathways and is thus associated with Tau phosphorylation in AD...
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    ..Decreased 5'-adenosine monophosphate kinase (AMPK) activity alone with inhibited autophagy could be detected in rats within 3 weeks after aortic banding (AB)...
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    ..activity of MAP kinases, NF-?B, and AP-1, while they increased heme oxygenase-1 expression by upregulating AMPK-Nrf2 signaling. Overall, the effect of comp 3 on anti-inflammatory signaling was much stronger than comp 1...
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    ..acnes strains, by triggering a local increase in autophagic activity, might exert a profound effect on several physiological processes responsible for the maintenance of skin tissue homeostasis. ..
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    ..the molecular mechanism of the effect of PAP on NAFLD, expression levels of AMP-activated protein kinase (AMPK)/NF-?B pathway in the liver were determined by western blot analysis, respectively...
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    ..miR-34a inhibited the PPARα signaling pathway by binding to sites in the 3'UTR of AdipoR2 genes and the AMPK pathway. Consequently, this increased the fat content and decreased the mitochondrial content in HepG2 cells...
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    Energy sensing by the AMP-activated protein kinase (AMPK) is of fundamental importance in cell biology. In the pancreatic β-cell, AMPK is a central regulator of insulin secretion...
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    ..while miR-33, as a key regulator of cholesterol transport, regulates lipid metabolism through CROT, PGC-1?, AMPK and other genes located in the mitochondria...
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    ..analog of metformin (norMitoMet) in experimental pairs of wild-type and AMP-activated protein kinase (AMPK)-, serine hydroxymethyltransferase 2 (SHMT2)- and mCI-null cells, we provide evidence that metformin increases the ..
  82. Zhang B, Lakshmanan J, Du Y, Smith J, Harbrecht B. Cell-specific regulation of iNOS by AMP-activated protein kinase in primary rat hepatocytes. J Surg Res. 2018;221:104-112 pubmed publisher
    AMP-activated protein kinase (AMPK) regulates several metabolic pathways in hepatocytes that are critical to the hepatic response to sepsis and shock...
  83. Qin X, Jiang T, Liu S, Tan J, Wu H, Zheng L, et al. Effect of metformin on ossification and inflammation of fibroblasts in ankylosing spondylitis: An in vitro study. J Cell Biochem. 2018;119:1074-1082 pubmed publisher
    ..And it is also a kind of specific agonists for adenosine 5'-monophosphate activated protein kinase (AMPK), which is blocked in the process of AS...
  84. Su H, Liu W. PIK3C3/VPS34 control by acetylation. Autophagy. 2017;: pubmed publisher
    ..mechanism is utilized not only by starvation-induced autophagy but also by autophagy without the involvement of AMPK, MTORC1 or ULK1...
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    ..and especially the LM B cell subset, which is also showing spontaneous activation of AMP-activated protein kinase (AMPK), the energy sensing enzyme which is ubiquitously expressed in mammalian cells...
  86. Yang K, Long Q, Saja K, Huang F, Pogwizd S, Zhou L, et al. Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophy. Sci Rep. 2017;7:10501 pubmed publisher
    ..The reduced ATP hydrolysis activated AMPK activity in IF1 KO hearts, which together facilitated autophagy...
  87. Chen Y, Chen C, Dong B, Xing F, Huang H, Yao F, et al. AMPK attenuates ventricular remodeling and dysfunction following aortic banding in mice via the Sirt3/Oxidative stress pathway. Eur J Pharmacol. 2017;814:335-342 pubmed publisher
    Although recent findings have suggested that AMP-activated protein kinase (AMPK) exerts inhibitory effects on cardiac remodeling secondary to hypertension, the mechanism and optimal duration of treatment remain unknown...
  88. Adrian L, Lenski M, Tödter K, Heeren J, Bohm M, Laufs U. AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes. Lipids. 2017;52:737-750 pubmed publisher
    ..using rat ventricular cardiomyocytes revealed an increased phosphorylation of AMP activated protein kinase ? (AMPK?) to 155 ± 19% and its target acetyl-CoA-carboxylase to 177 ± 23% by CoFA...
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    ..signaling pathway, mechanistic target of rapamycin (mTOR), and adenosine monophosphate-activated protein kinase (AMPK)-play important roles in regulating physiological decisions to reproduce, grow, and age...
  90. Edifizi D, Schumacher B. Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging. Int J Mol Sci. 2017;18: pubmed publisher
    ..in a DNA damage response (DDR) network that includes epidermal growth factor (EGF)-, AMP-activated protein kinases (AMPK)- and the target of rapamycin (TOR)-like signalling pathways, which are known regulators of growth, metabolism, and ..
  91. Ming W, Lu G, Xin S, Huanyu L, Yinghao J, Xiaoying L, et al. Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation. Biochem Biophys Res Commun. 2016;476:412-419 pubmed publisher
    ..Moreover, MOTS-c increased phosphorylated AMPK levels, and compound C, an AMPK inhibitor, could partially abrogate the effects of the MOTS-c on osteoclastogenesis...
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    ..oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and increased the activation of AMP-activated protein kinase (AMPK) in the lung. NPS 2143 also downregulated the activation of nuclear factor-kappa B (NF-?B) in the lung...