amphiregulin

Summary

Gene Symbol: amphiregulin
Description: amphiregulin
Alias: AREGB, CRDGF, SDGF, amphiregulin, amphiregulin B, colorectum cell-derived growth factor, schwannoma-derived growth factor
Species: human
Products:     amphiregulin

Top Publications

  1. Cook P, Mattox P, Keeble W, Pittelkow M, Plowman G, Shoyab M, et al. A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. Mol Cell Biol. 1991;11:2547-57 pubmed
    ..of the first 20 NH2-terminal amino acid residues of purified KAF revealed identity to the NH2 terminus of human amphiregulin (AR)...
  2. Tokumaru S, Higashiyama S, Endo T, Nakagawa T, Miyagawa J, Yamamori K, et al. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J Cell Biol. 2000;151:209-20 pubmed
    ..These findings indicate that the shedding of EGFR ligands represents a critical event in keratinocyte migration, and suggest their possible use as an effective clinical treatment in the early phases of wound healing. ..
  3. Okumura S, Sagara H, Fukuda T, Saito H, Okayama Y. FcepsilonRI-mediated amphiregulin production by human mast cells increases mucin gene expression in epithelial cells. J Allergy Clin Immunol. 2005;115:272-9 pubmed
    ..Secretion of a protein, amphiregulin, by the MCs was measured by ELISA...
  4. Eckstein N, Servan K, Girard L, Cai D, von Jonquieres G, Jaehde U, et al. Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. J Biol Chem. 2008;283:739-50 pubmed
    ..expression of genes encoding the ligands for the ERBB signaling cascade and found a selective up-regulation of amphiregulin expression, which occurred at later stages of cisplatin resistance development...
  5. Busser B, Sancey L, Brambilla E, Coll J, Hurbin A. The multiple roles of amphiregulin in human cancer. Biochim Biophys Acta. 2011;1816:119-31 pubmed publisher
    b>Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR)...
  6. Plowman G, Green J, McDonald V, Neubauer M, Disteche C, Todaro G, et al. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol Cell Biol. 1990;10:1969-81 pubmed
    We have isolated the gene for a novel growth regulator, amphiregulin (AR), that is evolutionarily related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha)...
  7. Shoyab M, Plowman G, McDonald V, Bradley J, Todaro G. Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science. 1989;243:1074-6 pubmed
    The complete amino acid sequence of amphiregulin, a bifunctional cell growth modulator, was determined...
  8. Shoyab M, McDonald V, Bradley J, Todaro G. Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci U S A. 1988;85:6528-32 pubmed
    A glycoprotein, termed amphiregulin (AR), inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells...
  9. Gschwind A, Hart S, Fischer O, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J. 2003;22:2411-21 pubmed
    ..with the GPCR agonists LPA or carbachol specifically results in metalloprotease cleavage and release of amphiregulin (AR)...

More Information

Publications106 found, 100 shown here

  1. Berasain C, García Trevijano E, Castillo J, Erroba E, Lee D, Prieto J, et al. Amphiregulin: an early trigger of liver regeneration in mice. Gastroenterology. 2005;128:424-32 pubmed
    ..Activation of the epidermal growth factor receptor is thought to play an important role in liver regeneration. Amphiregulin is a member of the epidermal growth factor family whose expression is not detectable in healthy liver...
  2. Wang S, Oh C, Cho S, Hu G, Martin R, Demissie Sanders S, et al. Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts. J Allergy Clin Immunol. 2005;115:287-94 pubmed
    b>Amphiregulin is a member of the epidermal growth factor family and has been shown to stimulate the proliferation of human keratinocytes in an autocrine manner...
  3. Rittie L, Varani J, Kang S, Voorhees J, Fisher G. Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006;126:732-9 pubmed
    ..treatment of human skin with all-trans retinoic acid (tRA) induces EGFR ligands heparin-binding (HB)-EGF and amphiregulin (AR), and reduces betacellulin mRNA levels...
  4. Willmarth N, Ethier S. Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. J Biol Chem. 2006;281:37728-37 pubmed
    b>Amphiregulin (AR) autocrine loops have been associated with several types of cancer. We demonstrate that SUM149 breast cancer cells have a self-sustaining AR autocrine loop...
  5. Berasain C, Castillo J, Perugorria M, Prieto J, Avila M. Amphiregulin: a new growth factor in hepatocarcinogenesis. Cancer Lett. 2007;254:30-41 pubmed
    b>Amphiregulin (AR) is a member of the epidermal growth factor family and a ligand of the epidermal growth factor receptor (EGFR)...
  6. Isokane M, Hieda M, Hirakawa S, Shudou M, Nakashiro K, Hashimoto K, et al. Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription. J Cell Sci. 2008;121:3608-18 pubmed publisher
    b>Amphiregulin (AR), a member of the EGF family, is synthesized as a type I transmembrane protein precursor (proAR) and expressed on the cell surface...
  7. Singh B, Schneider M, Knyazev P, Ullrich A. UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines. Int J Cancer. 2009;124:531-9 pubmed publisher
    ..Furthermore, using neutralizing antibodies we found that proligand amphiregulin was required for UV-induced EGFR activation in SCC-9 cells...
  8. Matsumoto K, Fukuda S, Nakamura Y, Saito H. Amphiregulin production by human eosinophils. Int Arch Allergy Immunol. 2009;149 Suppl 1:39-44 pubmed publisher
    b>Amphiregulin (AREG) plays critical roles in mammary gland development, immune responses against nematode infection, and mucous production in the lung...
  9. Latasa M, Salis F, Urtasun R, Garcia Irigoyen O, Elizalde M, Uriarte I, et al. Regulation of amphiregulin gene expression by ?-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. PLoS ONE. 2012;7:e52711 pubmed publisher
    ..We and others have identified a central role for the EGFR ligand amphiregulin (AR) in the proliferation, survival and drug resistance of HCC cells...
  10. Hurbin A, Dubrez L, Coll J, Favrot M. Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines. J Biol Chem. 2002;277:49127-33 pubmed
    ..In this report, we have identified a new mechanism of apoptosis inhibition by amphiregulin through an IGF1-dependent survival pathway in non-small cell lung cancer (NSCLC) cells: amphiregulin activates ..
  11. Sternlicht M, Sunnarborg S. The ADAM17-amphiregulin-EGFR axis in mammary development and cancer. J Mammary Gland Biol Neoplasia. 2008;13:181-94 pubmed publisher
    ..Among other things, ductal development requires the epidermal growth factor receptor (EGFR), its ligand amphiregulin (AREG), and the transmembrane metalloproteinase ADAM17, which can cleave and release AREG from the cell surface ..
  12. Baillo A, Giroux C, Ethier S. Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer. J Cell Physiol. 2011;226:2691-701 pubmed publisher
    We have previously shown that SUM-149 human breast cancer cells require an amphiregulin (AREG) autocrine loop for cell proliferation...
  13. Yang N, Morrison C, Liu P, Miecznikowski J, Bshara W, Han S, et al. TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin. Cell Cycle. 2012;11:2922-30 pubmed publisher
    ..TAZ also leads to cell migration and anchorage-independent growth in soft agar. Furthermore, we identified amphiregulin (AREG), an epidermal growth factor receptor (EGFR) ligand, as a target of TAZ...
  14. Nakayama H, Fukuda S, Matsushita N, Nishida Fukuda H, Inoue H, Shirakata Y, et al. Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes. J Biol Chem. 2013;288:10338-48 pubmed publisher
    ..In this study, we investigated the molecular mechanism of the autoinduction of amphiregulin (AREG), a member of the EGF family...
  15. Niringiyumukiza J, Cai H, Xiang W. Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation. Reprod Biol Endocrinol. 2018;16:43 pubmed publisher
    ..Additionally, assessments of PGE2 protein and receptor expression levels should be taken into consideration. ..
  16. Choi Y, Wilson K, Hannon P, Rosewell K, Brannstrom M, Akin J, et al. Coordinated Regulation Among Progesterone, Prostaglandins, and EGF-Like Factors in Human Ovulatory Follicles. J Clin Endocrinol Metab. 2017;102:1971-1982 pubmed publisher
    ..In vitro studies indicated that collaborative actions of P4/PGR and EGF signaling are required for hCG-induced increases in PTG production and potentiation of EGF signaling in human periovulatory granulosa cells. ..
  17. Yang X, Fu J, Yang R, Liu W, Zhang T, Yang B, et al. EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis. J Neuroinflammation. 2016;13:274 pubmed
    ..tyrosine phosphorylation of cellular EGFR in a ligand-dependent manner involving the EGF-like ligand HB-EGF, amphiregulin (AREG), and epiregulin (EREG) and led to heterodimerization of EGFR/ErbB3...
  18. Etxeberria U, Castilla Madrigal R, Lostao M, Martínez J, Milagro F. Trans-resveratrol induces a potential anti-lipogenic effect in lipopolysaccharide-stimulated enterocytes. Cell Mol Biol (Noisy-le-grand). 2015;61:9-16 pubmed
    ..but also in cell death and survival function, such as transcription factors Krüppel-like factor 5 (KLF5) and amphiregulin (AREG), were also significantly inhibited by trans-resveratrol pre-treatment...
  19. Bertolin K, Meinsohn M, Suzuki J, Gossen J, Schoonjans K, Duggavathi R, et al. Ovary-specific depletion of the nuclear receptor Nr5a2 compromises expansion of the cumulus oophorus but not fertilization by intracytoplasmic sperm injection. Biol Reprod. 2017;96:1231-1243 pubmed publisher
    ..We found downregulation of epiregulin (Ereg), amphiregulin (Areg), betacellulin (Btc) and tumor necrosis factor stimulated gene-6 (Tnfaip6) transcripts in Nr5a2Amhr2-/- ..
  20. Puttabyatappa M, Al Alem L, Zakerkish F, Rosewell K, Brannstrom M, Curry T. Induction of Tissue Factor Pathway Inhibitor 2 by hCG Regulates Periovulatory Gene Expression and Plasmin Activity. Endocrinology. 2017;158:109-120 pubmed publisher
    ..Knockdown of TFPI2 also reduced expression of multiple genes including interleukin 6 (Il6) and amphiregulin (Areg)...
  21. Ren Y, Liu Z, Mullany L, Fan C, Richards J. Growth Arrest Specific-1 (GAS1) Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice. Biol Reprod. 2016;94:44 pubmed publisher
    ..The C/EBP target Gas1 is induced in granulosa cells and is associated with ovulation and luteinization. ..
  22. Schumacher Y, Aparicio T, Ourabah S, Baraille F, Martin A, Wind P, et al. Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth. Oncogene. 2016;35:2602-14 pubmed publisher
    ..during colonic carcinogenesis, revealed some notable pro-tumorigenic CRTC1 target genes including NR4A2, COX2, amphiregulin (AREG) and IL-6...
  23. Bazzani L, Donnini S, Finetti F, Christofori G, Ziche M. PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells. Oncotarget. 2017;8:31270-31287 pubmed publisher
    ..b>Amphiregulin (AREG) and Epiregulin (EREG) appear to be involved in nEGFR promoted by the PGE2/EP3-SRC axis...
  24. Chen Q, Zhang W, Ran H, Feng L, Yan H, Mu X, et al. PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway. PLoS ONE. 2014;9:e111423 pubmed publisher
    ..FSH-stimulated oocyte maturation dose-dependently, but these inhibitory effects could be reversed partially by amphiregulin (Areg), an EGF family member...
  25. Lee Y, Lee Y, Kim C, Jo K, Sohn E, Kim J, et al. Cnidium officinale extract and butylidenephthalide inhibits retinal neovascularization in vitro and in vivo. BMC Complement Altern Med. 2016;16:231 pubmed publisher
  26. Sisto M, Lisi S, Lofrumento D, Ingravallo G, Mitolo V, D Amore M. Expression of pro-inflammatory TACE-TNF-?-amphiregulin axis in Sjögren's syndrome salivary glands. Histochem Cell Biol. 2010;134:345-53 pubmed publisher
    The tumor-necrosis-factor-converting-enzyme (TACE)-TNF-?-Amphiregulin (AREG) axis plays an important pathogenic role in inflammatory and autoimmune disorders...
  27. Soueid J, Kourtian S, Makhoul N, Makoukji J, Haddad S, Ghanem S, et al. RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism. Sci Rep. 2016;6:19088 pubmed publisher
    ..These findings may lead to improved diagnosis of ASDs and informed genetic counseling, and may also lead to untapped therapeutic targets applicable to Lebanese and non-Lebanese patients. ..
  28. Fukami T, Yoshizato T, Miyamoto S, Yagi H, Yotsumoto F, Nabeshima K, et al. Amphiregulin regulates the production of human chorionic gonadotropin in trophoblasts. Life Sci. 2009;84:796-804 pubmed publisher
    ..b>Amphiregulin was primarily expressed throughout human pregnancy and stimulated the secretion of hCG, indicating that ..
  29. Osada H, Yoshitake Y, Ikeda T, Ishigaki Y, Takata T, Tomosugi N, et al. Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells. Mol Vis. 2011;17:159-69 pubmed
    ..A total of 18 secreted protein genes were upregulated more than twofold at either or both time points. Amphiregulin (AREG) and growth differentiation factor 15 (GDF15) were chosen because of their higher upregulation and ..
  30. Kneissl J, Hartmann A, Pfarr N, Erlmeier F, Lorber T, Keller S, et al. Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines. J Cancer Res Clin Oncol. 2017;143:573-600 pubmed publisher
    ..In this study, we analysed the involvement of the HER receptor ligands amphiregulin (AREG), epidermal growth factor (EGF), heparin-binding epidermal growth factor (HB-EGF) and transforming growth ..
  31. Cook P, Piepkorn M, Clegg C, Plowman G, DeMay J, Brown J, et al. Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest. 1997;100:2286-94 pubmed
    b>Amphiregulin (AR) is a heparin-binding, heparin-inhibited member of the epidermal growth factor (EGF) family and an autocrine growth factor for human keratinocytes...
  32. Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E, Basbaum C. Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin. J Biol Chem. 2003;278:26202-7 pubmed
    ..necrosis factor alpha-converting enzyme (a disintegrin and metalloproteinase (ADAM) 17) to cleave transmembrane amphiregulin, a ligand for the epidermal growth factor receptor (EGFR)...
  33. Zhang Q, Thomas S, Lui V, Xi S, Siegfried J, Fan H, et al. Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci U S A. 2006;103:6901-6 pubmed
    ..and metalloproteinse-17, undergoes a Src-dependent phosphorylation that regulates release of the EGFR ligand amphiregulin upon GRP treatment...
  34. Kariagina A, Xie J, Leipprandt J, Haslam S. Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers. Horm Cancer. 2010;1:229-44 pubmed publisher
    ..In both the normal gland and tumors, E+P-induced proliferation was mediated through the increased production of amphiregulin (Areg), an epidermal growth factor receptor (EGFR) ligand, and the activation of intracellular signaling ..
  35. Ahn E, Kim J, Kim G, Park Y. RASSF1A-mediated regulation of AREG via the Hippo pathway in hepatocellular carcinoma. Mol Cancer Res. 2013;11:748-58 pubmed publisher
    ..b>Amphiregulin (AREG), a target gene for Yes-associated protein (YAP), is a known oncogenic component of the Hippo pathway; ..
  36. Hall O, Limjunyawong N, Vermillion M, Robinson D, Wohlgemuth N, Pekosz A, et al. Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females. PLoS Pathog. 2016;12:e1005840 pubmed publisher
    ..protein leakage into the airway, improving pulmonary function, and upregulating the epidermal growth factor amphiregulin (AREG) in the lungs...
  37. Qin L, Partridge N. Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway. J Cell Biochem. 2005;96:632-40 pubmed
    ..Recently, we identified that amphiregulin (AR), an EGF-like ligand, is an immediate early gene for PTH treatment and has an important role in bone ..
  38. Liu F, Wu C, Chang D. TACE-dependent amphiregulin release is induced by IL-1? and promotes cell invasion in fibroblast-like synoviocytes in rheumatoid arthritis. Rheumatology (Oxford). 2014;53:260-9 pubmed publisher
    The aims of this study were to investigate the expression of amphiregulin (AREG) and TNF-?-converting enzyme (TACE) in fibroblast-like synoviocytes from humans with RA (FLS-RA) when stimulated with proinflammatory cytokines and to explore ..
  39. Reiss L, Fragoulis A, Siegl S, Platen C, Kan Y, Nautiyal J, et al. Interplay between nuclear factor erythroid 2-related factor 2 and amphiregulin during mechanical ventilation. Am J Respir Cell Mol Biol. 2014;51:668-77 pubmed publisher
    ..Nrf2 activity was quantified in ventilated isolated perfused mouse lungs (IPL). Regulation of amphiregulin (AREG) was investigated in BEAS-2B cells with inactivated Nrf2 or Keap1, the inhibitor of Nrf2, using a ..
  40. Yuan C, Sun X, Zhu C, Liu S, Wu L, Chen H, et al. Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells. Oncotarget. 2015;6:32138-53 pubmed publisher
    ..We found that HCC cells, both in vitro and in vivo, substantially secret and express amphiregulin (AR)...
  41. Wang S, Zhang Y, Wang Y, Ye P, Li J, Li H, et al. Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3?/Foxp3 Axis. J Biol Chem. 2016;291:21085-21095 pubmed
    ..The EGF-like growth factor Amphiregulin (AREG) protein was frequently up-regulated in a tissue microarray, which was associated with worse overall ..
  42. Nordgren T, Heires A, BAILEY K, Katafiasz D, Toews M, Wichman C, et al. Docosahexaenoic acid enhances amphiregulin-mediated bronchial epithelial cell repair processes following organic dust exposure. Am J Physiol Lung Cell Mol Physiol. 2018;314:L421-L431 pubmed publisher
    ..b>Amphiregulin (AREG), an EGFR ligand, mediates tissue repair and wound healing in the lung epithelium...
  43. Gupta A, Dong A, Lowe A. AGR2 gene function requires a unique endoplasmic reticulum localization motif. J Biol Chem. 2012;287:4773-82 pubmed publisher
    ..Using two different cell lines in which AGR2 induces expression of either the EGFR ligand amphiregulin or the transcription factor CDX2, only the highly conserved wild-type carboxyl-terminal KTEL motif results in ..
  44. Berasain C, Avila M. Amphiregulin. Semin Cell Dev Biol. 2014;28:31-41 pubmed publisher
    b>Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase...
  45. Carnet O, Lecomte J, Masset A, Primac I, Durré T, Maertens L, et al. Mesenchymal Stem Cells Shed Amphiregulin at the Surface of Lung Carcinoma Cells in a Juxtacrine Manner. Neoplasia. 2015;17:552-63 pubmed publisher
    ..exerted on tumor cells relies on an unprecedented juxtacrine action of BM-MSC, leading to the trans-shedding of amphiregulin (AREG) from the tumor cell membrane by tumor necrosis factor-α-converting enzyme carried by the BM-MSC ..
  46. Guerrant W, Kota S, Troutman S, Mandati V, Fallahi M, Stemmer Rachamimov A, et al. YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2-EGFR Signaling Axis. Cancer Res. 2016;76:3507-19 pubmed publisher
    ..which codes for COX-2, a key enzyme in prostaglandin biosynthesis, and AREG, which codes for the EGFR ligand, amphiregulin. Both AREG and prostaglandin E2 converge to activate signaling through EGFR...
  47. Karthaus M, Hofheinz R, Mineur L, Letocha H, Greil R, Thaler J, et al. Impact of tumour RAS/BRAF status in a first-line study of panitumumab + FOLFIRI in patients with metastatic colorectal cancer. Br J Cancer. 2016;115:1215-1222 pubmed publisher
    ..Data were analysed by tumour RAS (KRAS/NRAS) and BRAF status, and baseline amphiregulin (AREG) expression...
  48. Haskett S, Ding J, Zhang W, Thai A, Cullen P, Xu S, et al. Identification of Novel CD4+ T Cell Subsets in the Target Tissue of Sjögren's Syndrome and Their Differential Regulation by the Lymphotoxin/LIGHT Signaling Axis. J Immunol. 2016;197:3806-3819 pubmed
  49. Sisto M, Lorusso L, Ingravallo G, Lisi S. Exocrine Gland Morphogenesis: Insights into the Role of Amphiregulin from Development to Disease. Arch Immunol Ther Exp (Warsz). 2017;65:477-499 pubmed publisher
    b>Amphiregulin (AREG) is a well-characterized member of the epidermal growth factor (EGF) family and is one of the ligands of the EGF receptor (EGFR)...
  50. Islam M, Ikeguchi Y, Yamagami K, El Sharawy M, Yamauchi N. Development of an in vitro model to study uterine functions and early implantation using rat uterine explants. Cell Tissue Res. 2017;370:501-512 pubmed publisher
    ..Despite the necessity of comprehensive investigation, our results suggest that the cultured rat uterine explants can be a useful in vitro model to study uterine functions and early implantation. ..
  51. Schmucker H, Blanding W, Mook J, Wade J, Park J, Kwist K, et al. Amphiregulin regulates proliferation and migration of HER2-positive breast cancer cells. Cell Oncol (Dordr). 2018;41:159-168 pubmed publisher
    ..Many factors are involved in these processes, including growth factors. Amphiregulin (AREG) is involved in normal mammary development and the development of estrogen receptor (ER)-positive breast ..
  52. Yang Y, Leonard M, Zhang Y, Zhao D, Mahmoud C, Khan S, et al. HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1. Cancer Res. 2018;78:422-435 pubmed publisher
    ..i>Cancer Res; 78(2); 422-35. ©2017 AACR. ..
  53. Nagyova E, Nemcova L, Bujnakova Mlynarcikova A, Blaha M, Prochazka R, Scsukova S. Effect of bone morphogenetic protein-15 on gonadotropin-stimulated synthesis of hyaluronan and progesterone in porcine ovarian follicle. J Physiol Pharmacol. 2017;68:683-691 pubmed
    ..The present results indicate that the addition of BMP-15 to the gonadotropin-stimulated OCC cultured in serum-supplemented medium might improve oocyte-cumulus maturation. ..
  54. Chen C, Bejcek B, Kersey J. A mapping study of 13 genes on human chromosome bands 4q11-->q25. Cytogenet Cell Genet. 1995;69:260-5 pubmed
    ..the gamma-interferon induced protein 10 (INP10), bone morphogenetic protein 3 (BMP3), annexin III (ANX3), KIT, amphiregulin (AREG), immunoglobulin J polypeptide (IGJ), deoxycytidine kinase (DCK) and MLLT2 genes were not linked to one ..
  55. Stern K, Place T, Lill N. EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate. Biochem J. 2008;410:585-94 pubmed
    ..However, less is known about EGF-R fates induced by the ligands BTC (betacellulin) and AR (amphiregulin)...
  56. Lu X, Wang Q, Hu G, Van Poznak C, Fleisher M, Reiss M, et al. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev. 2009;23:1882-94 pubmed publisher
    ..Proteolytic release of membrane-bound epidermal growth factor (EGF)-like growth factors, including Amphiregulin (AREG), heparin-binding EGF (HB-EGF), and transforming growth factor alpha (TGFalpha) from tumor cells suppress ..
  57. Guzman M, Shao J, Sheng H. Pro-neoplastic effects of amphiregulin in colorectal carcinogenesis. J Gastrointest Cancer. 2013;44:211-21 pubmed publisher
    Epidermal growth factor (EGF) family plays critical roles in intestinal epithelial growth and transformation. Amphiregulin (AREG) is a member of the EGF family, and has been suggested to be more important to tumor versus normal growth...
  58. Liu K, Lin D, Ouyang Y, Pang L, Guo X, Wang S, et al. Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells. Tumour Biol. 2017;39:1010428317695026 pubmed publisher
    ..In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin expression in a p53-dependent manner...
  59. Basbaum C, Li D, Gensch E, Gallup M, Lemjabbar H. Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR). Novartis Found Symp. 2002;248:171-6; discussion 176-80, 277-82 pubmed
    ..The mode of activation of EGFR in response to bacterial lipoteichoic acid involves cleavage of the transmembrane ligand HBEGF by ADAM 10, whereas the activation of EGFR in response to smoke involves cleavage of amphiregulin by ADAM 17.
  60. Shim J, Park S, Kim D, Shim J, Jung H, Park M. The effect of interleukin-4 and amphiregulin on the proliferation of human airway smooth muscle cells and cytokine release. J Korean Med Sci. 2008;23:857-63 pubmed publisher
    ..We investigated the effect of IL-4 and amphiregulin, an epidermal growth factor family member, on the proliferation of human ASM cells and on the release of ..
  61. Stoll S, Johnson J, Li Y, Rittie L, Elder J. Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth. J Invest Dermatol. 2010;130:2031-40 pubmed publisher
    The EGFR ligand amphiregulin (AREG) has been implicated as an important autocrine growth factor in several epithelial malignancies and in psoriasis, a hyperproliferative skin disorder...
  62. Gephart J, Singh B, Higginbotham J, Franklin J, Gonzalez A, FOLSCH H, et al. Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin. Traffic. 2011;12:1793-804 pubmed publisher
    ..The EGF receptor (EGFR) and its ligand, amphiregulin (AREG), are transmembrane proteins delivered to the BL membrane in polarized epithelial cells...
  63. Ohchi T, Akagi Y, Kinugasa T, Kakuma T, Kawahara A, Sasatomi T, et al. Amphiregulin is a prognostic factor in colorectal cancer. Anticancer Res. 2012;32:2315-21 pubmed
    b>Amphiregulin is an epidermal growth factor (EGF) which is a ligand of epidermal growth factor receptor (EGFR). Amphiregulin is the most enhanced EGFR ligand in colon cancer...
  64. Chen J, Chen Y, Lin C, Fong Y, Hsu C, Tsai C, et al. Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway. Oncotarget. 2015;6:11434-46 pubmed
    ..The most lethal aspect is its metastatic property. We demonstrated that amphiregulin (AR) is significantly upregulated in highly aggressive cells. AR silencing markedly suppressed cell migration...
  65. Kansra S, Stoll S, Johnson J, Elder J. Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. Mol Biol Cell. 2004;15:4299-309 pubmed
    ..antibody 225 IgG, by two different metalloproteinase inhibitors, and by neutralizing antibodies against amphiregulin (AR)...
  66. LaMarca H, Rosen J. Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage. Breast Cancer Res. 2007;9:304 pubmed
    ..Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis...
  67. Revillion F, Lhotellier V, Hornez L, Bonneterre J, Peyrat J. ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis. Ann Oncol. 2008;19:73-80 pubmed
    ..Epidermal growth factor (EGF), transforming growth factor-alpha (TGFalpha), amphiregulin (AREG), betacellulin (BTC), heparin-binding EGF-like growth factor (HB-EGF), epiregulin (EREG) and neuregulins1-..
  68. McBryan J, Howlin J, Napoletano S, Martin F. Amphiregulin: role in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2008;13:159-69 pubmed publisher
    ..b>Amphiregulin is the most abundant EGF-like growth factor in the pubertal mammary gland...
  69. Gui Y, Zhang J, Liang W, Cai Z. [Expression of amphiregulin in human endometrium during the menstrual cycle]. Beijing Da Xue Xue Bao Yi Xue Ban. 2008;40:241-4 pubmed
    To investigate the expression of amphiregulin in human endometrium during the menstrual cycle. Endometrial tissues were collected from the patients undergoing hysterectomy or endometrial biopsy...
  70. Dong A, Gupta A, Pai R, Tun M, Lowe A. The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation. J Biol Chem. 2011;286:18301-10 pubmed publisher
    ..The present study shows that AGR2 induces expression of amphiregulin (AREG), a growth promoting EGFR ligand...
  71. Saeki M, Egusa H, Kamano Y, Kakihara Y, Houry W, Yatani H, et al. Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA. PLoS ONE. 2013;8:e67326 pubmed publisher
    ..Here, we identified amphiregulin, an EGFR ligand, as a target of WD repeat protein Monad, a component of R2TP/prefoldin-like complex, in MDA-MB-..
  72. Lindstrom S, Thompson D, Paterson A, Li J, Gierach G, Scott C, et al. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Nat Commun. 2014;5:5303 pubmed publisher
    ..These results provide further evidence of a shared genetic basis between mammographic density and breast cancer and illustrate the power of studying intermediate quantitative phenotypes to identify putative disease-susceptibility loci. ..
  73. Kubanov A, Katunina O, Chikin V. Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis. Bull Exp Biol Med. 2015;159:318-22 pubmed publisher
    Expression of neural marker PGP9.5, amphiregulin, semaphorin-3A, calcitonin gene-related peptide and its receptor, nerve growth factor and its receptor, substance P and its receptor, and expression frequency were analyzed in biopsy ..
  74. Liu J, Tsao Y, Hou C. Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma. Oncotarget. 2015;6:40880-95 pubmed publisher
    Osteosarcoma is a common, high malignant, and metastatic bone cancer. Amphiregulin (AREG) has been associated with cancer cellular activities...
  75. Kallifatidis G, Munoz D, Singh R, Salazar N, Hoy J, Lokeshwar B. β-Arrestin-2 Counters CXCR7-Mediated EGFR Transactivation and Proliferation. Mol Cancer Res. 2016;14:493-503 pubmed publisher
    ..g., AREG/amphiregulin) and G-protein-coupled receptor signaling...
  76. Wang B, Yong H, Zhu H, Ni D, Tang S, Zhang S, et al. Abnormal amphiregulin expression correlates with gastric cancer prognosis. Oncotarget. 2016;7:76684-76692 pubmed publisher
    ..Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of ..
  77. Pogrmic Majkic K, Samardzija D, Stojkov Mimic N, Vukosavljevic J, Trninić Pjević A, Kopitović V, et al. Atrazine suppresses FSH-induced steroidogenesis and LH-dependent expression of ovulatory genes through PDE-cAMP signaling pathway in human cumulus granulosa cells. Mol Cell Endocrinol. 2018;461:79-88 pubmed publisher
    ..Addition of hCG 48 h after FSH and ATR treatment did not trigger maximal expression of the ovulatory genes amphiregulin (AREG) and epiregulin (EREG). Mechanistic experiments showed that ATR activated cPDE and decreased cAMP level...
  78. Jeffery H, McDowell P, Lutz P, Wawman R, Roberts S, Bagnall C, et al. Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score. PLoS ONE. 2017;12:e0188649 pubmed publisher
    ..Intrahepatic ILC2 secreted the immunoregulatory and repair cytokines IL-13 and amphiregulin. Intrahepatic ILC2 express receptors allowing them to be recruited to bile ducts in inflamed portal tracts...
  79. Culouscou J, Remacle Bonnet M, Carlton G, Plowman G, Shoyab M. Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. Growth Factors. 1992;7:195-205 pubmed
    ..Partial N-terminal amino acid sequence of CRDGF showed identity to amphiregulin (AR), an EGF-related protein...
  80. Berquin I, Dziubinski M, Nolan G, Ethier S. A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin. Oncogene. 2001;20:4019-28 pubmed
    ..Clone H55a#1 contained a library insert encoding amphiregulin. This EGFR ligand was able to confer EGF independence when transduced into HME cells...
  81. Chung E, Cook P, Parkos C, Park Y, Pittelkow M, Coffey R. Amphiregulin causes functional downregulation of adherens junctions in psoriasis. J Invest Dermatol. 2005;124:1134-40 pubmed
    Overexpression of amphiregulin (AR) has been linked to psoriasis in mouse and man...
  82. Bles N, Di Pietrantonio L, Boeynaems J, Communi D. ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion. Blood. 2010;116:3219-26 pubmed publisher
    ..b>Amphiregulin was the most highly up-regulated gene in response to ATP?S...
  83. Ma L, Huet E, Serova M, Berthois Y, Calvo F, Mourah S, et al. Antisense inhibition of amphiregulin expression reduces EGFR phosphorylation in transformed human breast epithelial cells. Anticancer Res. 2010;30:2101-6 pubmed
    ..In this work, we investigated the role of the EGFR ligand amphiregulin (AR) in modulating EGFR activation...
  84. Humaidan P, Westergaard L, Mikkelsen A, Fukuda M, Yding Andersen C. Levels of the epidermal growth factor-like peptide amphiregulin in follicular fluid reflect the mode of triggering ovulation: a comparison between gonadotrophin-releasing hormone agonist and urinary human chorionic gonadotrophin. Fertil Steril. 2011;95:2034-8 pubmed publisher
    To detect differences in follicular fluid (FF) levels of amphiregulin (AR), depending on mode of triggering final oocyte maturation. Prospective randomized trial. Three IVF units...
  85. Higginbotham J, Demory Beckler M, Gephart J, Franklin J, Bogatcheva G, Kremers G, et al. Amphiregulin exosomes increase cancer cell invasion. Curr Biol. 2011;21:779-86 pubmed publisher
    ..and juxtacrine are recognized modes of action for mammalian EGFR ligands including EGF, TGF-α (TGFα), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin, epiregulin, and epigen...
  86. Levi Y, Barshack I, Avivi K, Bar Ilan D, Gutman M, Aderka D, et al. [Correlation between the presence of Kras mutation and the presence of the proteins epiregulin and amphiregulin in colon cancer tissue]. Harefuah. 2013;152:326-9, 369 pubmed
    ..New guidelines require K-ras mutation analysis before anti-EGFR treatment is provided. The proteins Amphiregulin and Epiregulin belong to the Epidermal growth factors family (EGF, that act through the EGFR...
  87. McKee C, Sigala B, Soeda J, Mouralidarane A, Morgan M, Mazzoccoli G, et al. Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis. Sci Rep. 2015;5:8812 pubmed publisher
    b>Amphiregulin (AR) involvement in liver fibrogenesis and hepatic stellate cells (HSC) regulation is under study...
  88. Li Y, Stoll S, Sekhon S, Talsma C, Camhi M, Jones J, et al. Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands. Exp Dermatol. 2016;25:187-93 pubmed publisher
    To explore the role of amphiregulin in inflammatory epidermal hyperplasia, we overexpressed human AREG (hAREG) in FVB/N mice using a bovine K5 promoter...
  89. Shinomiya H, Ito Y, Kubo M, Yonezawa K, Otsuki N, Iwae S, et al. Expression of amphiregulin in mucoepidermoid carcinoma of the major salivary glands: a molecular and clinicopathological study. Hum Pathol. 2016;57:37-44 pubmed publisher
    In mucoepidermoid carcinoma (MEC), CRTC1-MAML2 fusion indicates a favorable prognosis. Amphiregulin (AREG), an epidermal growth factor receptor (EGFR) ligand, has been shown to be a downstream target of CRTC1-MAML2 fusion, and to play a ..
  90. Reddy K, Krueger J, Kondapaka S, Diglio C. Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells. Int J Cancer. 1999;82:268-73 pubmed
    ..In a previous study, we have shown that EGF and amphiregulin upregulate MMP-9 in metastatic SKBR-3 cells but have no effect on MMP-2 secretion...
  91. Freimann S, Ben Ami I, Dantes A, Ron El R, Amsterdam A. EGF-like factor epiregulin and amphiregulin expression is regulated by gonadotropins/cAMP in human ovarian follicular cells. Biochem Biophys Res Commun. 2004;324:829-34 pubmed
    Epiregulin and amphiregulin are growth factors involved in cancer development, but their potential role in signaling in the gonads is still obscure...
  92. Chokki M, Eguchi H, Hamamura I, Mitsuhashi H, Kamimura T. Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. FEBS J. 2005;272:6387-99 pubmed
    ..Previous results have shown that HAT enhances the release of amphiregulin (AR); further, it causes MUC5AC gene expression through the AR-epidermal growth factor receptor pathway in the ..