AMOT

Summary

Gene Symbol: AMOT
Description: angiomotin
Alias: angiomotin p130 isoform, angiomotin p80 isoform
Species: human

Top Publications

  1. ncbi Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation
    Huizhe Huang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Development 134:979-88. 2007
  2. ncbi p130-angiomotin associates to actin and controls endothelial cell shape
    Mira Ernkvist
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, Stockholm, Sweden
    FEBS J 273:2000-11. 2006
  3. pmc Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation
    B Troyanovsky
    Center for Genomics Research and Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Cell Biol 152:1247-54. 2001
  4. ncbi Angiomotin regulates endothelial cell-cell junctions and cell motility
    Anders Bratt
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, R8 03 Karolinska University Hospital, 171 76 Stockholm, Sweden
    J Biol Chem 280:34859-69. 2005
  5. ncbi A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
    Clark D Wells
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell 125:535-48. 2006
  6. pmc Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation
    Siew Wee Chan
    From the Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673 and
    J Biol Chem 288:37296-307. 2013
  7. doi The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation
    Chenji Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China
    Biochem J 444:279-89. 2012
  8. pmc The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish
    Zhiqiang Li
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    J Biol Chem 287:13005-15. 2012
  9. pmc Membrane traffic as a coordinator of cell migration and junction remodeling
    Chuanshen Wu
    Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine Cleveland, OH USA
    Commun Integr Biol 4:703-5. 2011
  10. ncbi Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation
    Hiromichi Matsumoto
    Laboratory of Animal Breeding and Reproduction, Division of Animal Science, Faculty of Agriculture, Utsunomiya University, Tochigi 321 8505, Japan
    J Reprod Dev 58:649-53. 2012

Scientific Experts

  • Wanjin Hong
  • P Celec
  • B R Zetter
  • Hiromichi Matsumoto
  • Anders Bratt
  • Lars Holmgren
  • Mira Ernkvist
  • Tetyana Levchenko
  • Chunling Yi
  • Karin Aase
  • Clark D Wells
  • Siew Wee Chan
  • Akihiko Shimono
  • Niina Veitonmaki
  • William P Ranahan
  • Bin Zhao
  • Brigitte Heller
  • Yujuan Zheng
  • Huizhe Huang
  • Arindam Majumdar
  • Maria J G Fernandes
  • Olivier Birot
  • Julie Moreau
  • Jimmy Stalin
  • Jacob J Adler
  • Xiaoming Dai
  • Jin Yang
  • Xu Li
  • Wenqi Wang
  • Chenji Wang
  • Anat Stemmer-Rachamimov
  • Maddalena Arigoni
  • T Oka
  • Joseph L Kissil
  • Zhiqiang Li
  • Scott Troutman
  • Chun Jye Lim
  • Kun Liang Guan
  • Di Wu
  • Murugan Paramasivam
  • Claire Webb
  • Chuanshen Wu
  • Whitney Smith-Kinnaman
  • Arie Horowitz
  • Nathalie Luna Persson
  • Yong Yu
  • Yeqi Wang
  • Anming Meng
  • Federica Cavallo
  • Manuela Iezzi
  • Stéphane Audebert
  • Jean Paul Borg
  • Valérie Gagné
  • Claudia Curcio
  • Indranil Sinha
  • Staffan Nyström
  • Yue Ming
  • Anders Kvanta
  • Yuko Sugihara-Mizuno
  • Billie A Moore-Scott
  • Mathieu Lord
  • Noor Dawany
  • Alexandrine Foucault-Bertaud
  • Nathalie Bardin
  • Michel Aurrand-Lions
  • Yiqiang Zhao
  • Meijuan Tian
  • Stephane Robert
  • Peijun Liu
  • Daniel Lafitte
  • Mark G Goebl
  • Yuyao Li
  • Daqing Jin
  • Ross R Cocklin
  • Caroline Subrini
  • Qin Liu
  • Misook Oh
  • Florence Sabatier
  • Robert J Ingham
  • Fusheng Guo
  • Francoise Dignat-George
  • Ivan Tan
  • Xiaocan Guo
  • Lauren R Bringman
  • Tao P Zhong
  • Brigitte L Heller
  • Marcel Blot-Chabaud
  • Peilu She
  • Lucas Hubert
  • Dandan Jiang

Detail Information

Publications45

  1. ncbi Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation
    Huizhe Huang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Development 134:979-88. 2007
    Angiomotin (Amot), the founding member of the Motin family, is involved in angiogenesis by regulating endothelial cell motility, and is required for visceral endoderm movement in mice...
  2. ncbi p130-angiomotin associates to actin and controls endothelial cell shape
    Mira Ernkvist
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, Stockholm, Sweden
    FEBS J 273:2000-11. 2006
    ..We propose that p80- and p130-angiomotin play coordinating roles in tube formation by affecting cell migration and cell shape, respectively...
  3. pmc Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation
    B Troyanovsky
    Center for Genomics Research and Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Cell Biol 152:1247-54. 2001
    ..These findings indicate that angiostatin inhibits cell migration by interfering with angiomotin activity in endothelial cells...
  4. ncbi Angiomotin regulates endothelial cell-cell junctions and cell motility
    Anders Bratt
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, R8 03 Karolinska University Hospital, 171 76 Stockholm, Sweden
    J Biol Chem 280:34859-69. 2005
    ..We conclude that angiomotin, in addition to controlling cell motility, may play a role in the assembly of endothelial cell-cell junctions...
  5. ncbi A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
    Clark D Wells
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell 125:535-48. 2006
    ..Rich1 binds the scaffolding protein angiomotin (Amot) and is thereby targeted to a protein complex at tight junctions (TJs) containing the PDZ-domain proteins Pals1, ..
  6. pmc Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation
    Siew Wee Chan
    From the Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673 and
    J Biol Chem 288:37296-307. 2013
    ..In this report, we have identified angiomotin (Amot) family members as novel substrates of Hippo core kinases...
  7. doi The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation
    Chenji Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China
    Biochem J 444:279-89. 2012
    b>AMOT (angiomotin) is a membrane-associated protein that is expressed in ECs (endothelial cells) and controls migration, TJ (tight junction) formation, cell polarity and angiogenesis...
  8. pmc The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish
    Zhiqiang Li
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    J Biol Chem 287:13005-15. 2012
    ..is up-regulated due to an axin1 mutation, transforms eyeless phenotype into smaller eyes, whereas co-knockdown of amot, amotl1, and amotl2 leads to development of smaller eyes in mbl heterozygotes...
  9. pmc Membrane traffic as a coordinator of cell migration and junction remodeling
    Chuanshen Wu
    Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine Cleveland, OH USA
    Commun Integr Biol 4:703-5. 2011
    ..RhoA-specific guanine exchange factor (GEF) Syx, the scaffold protein Mupp1, and the phospholipid binding protein Amot.1 We found that RhoA co-trafficked with this complex on the same endocytic vesicles, and that its cellular activity ..
  10. ncbi Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation
    Hiromichi Matsumoto
    Laboratory of Animal Breeding and Reproduction, Division of Animal Science, Faculty of Agriculture, Utsunomiya University, Tochigi 321 8505, Japan
    J Reprod Dev 58:649-53. 2012
    ..Increased vascular permeability and angiogenesis are hallmarks of the implantation process in the uterus. Angiomotin (Amot), which is a vascular angiogenesis-related protein, belongs to the motin family...
  11. pmc PTPN14 is required for the density-dependent control of YAP1
    Wenqi Wang
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 26:1959-71. 2012
    ..Collectively, these data suggest that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1...
  12. pmc The effects of anti-inflammatory and anti-angiogenic DNA vaccination on diabetic nephropathy in rats
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, 811 08 Bratislava, Slovakia
    Hum Gene Ther 23:158-66. 2012
    ..Angiomotin (Amot) is a novel angiogenesis modulator...
  13. pmc Soluble melanoma cell adhesion molecule (sMCAM/sCD146) promotes angiogenic effects on endothelial progenitor cells through angiomotin
    Jimmy Stalin
    Inserm UMR S 1076, Physiopathology of Endothelium, Aix Marseille University, Formation and Research Unit of Pharmacy, 13005 Marseille, France
    J Biol Chem 288:8991-9000. 2013
    ..This result is important to find novel target cells of sCD146 and for the development of therapeutic strategies based on EPC in the treatment of ischemic diseases...
  14. pmc A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors
    Maddalena Arigoni
    Molecular Biotechnology Center, University of Turin, Turin, Italy
    Angiogenesis 15:305-16. 2012
    Angiomotin (Amot) is one of several identified angiostatin receptors expressed by the endothelia of angiogenic tissues...
  15. pmc Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis
    Xiaoming Dai
    From the Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, Zhejiang 310058, China
    J Biol Chem 288:34041-51. 2013
    ..Here we report a novel role of the Hippo pathway in angiogenesis. Angiomotin p130 isoform (AMOTp130) is phosphorylated on a conserved HXRXXS motif by Lats1/2 downstream of GPCR signaling...
  16. doi The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis
    Chunling Yi
    Molecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Sci Signal 6:ra77. 2013
    ..Members of the scaffold protein angiomotin (Amot) family interact with several Hippo pathway components, including Yap (Yes-associated protein), and either ..
  17. pmc Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth
    Jacob J Adler
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 288:15181-93. 2013
    ..Thus, Amot130 repurposes AIP4 from its previously described role in degrading large tumor suppressor 1 to the inhibition of YAP and cell growth...
  18. doi Angiomotin'g YAP into the nucleus for cell proliferation and cancer development
    Wanjin Hong
    Institute of Molecular and Cell Biology, Singapore
    Sci Signal 6:pe27. 2013
    ..Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP and TAZ by ..
  19. doi Proteomic identification of angiomotin by ProteomeLab PF-2D and correlation with clinical outcome in human clear cell renal cell carcinoma
    Jin Yang
    Medical Oncology Department, The First Affiliated Hospital, College of Medicine, Xi an Jiaotong University, Xi an 710061, P R China
    Int J Oncol 42:2078-86. 2013
    ..Of the 13 differentially expressed proteins newly discovered in ccRCC, angiomotin (Amot) was the focus of this study since its role in ccRCC progression has been obscure...
  20. ncbi Angiomotin regulates visceral endoderm movements during mouse embryogenesis
    Akihiko Shimono
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Curr Biol 13:613-7. 2003
    ..Here we describe a role for mouse angiomotin (amot) in VE movements...
  21. pmc Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
    Murugan Paramasivam
    Department of Microbial and Physiological Systems and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 22:3725-33. 2011
    ..Like AMOTL2, the other angiomotin-family proteins AMOT and AMOTL1 also activate LATS2 through a novel conserved domain that binds and activates LATS2...
  22. doi Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP
    T Oka
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA, USA
    Oncogene 31:128-34. 2012
    YAP (Yes-associated protein) oncogene has been found to form a stable complex with members of the Angiomotin (Amot) family of proteins, which bind WW domains of YAP and sequester the protein in the cytoplasm and junctional complexes...
  23. pmc A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Cancer Cell 19:527-40. 2011
    ..Depletion of Angiomotin in Nf2(-/-) Schwann cells attenuates the Ras-MAPK signaling pathway, impedes cellular proliferation in vitro and tumorigenesis in vivo...
  24. doi Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway
    Claire Webb
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK BA2 7AY
    Biochemistry 50:3300-9. 2011
    ..Our results indicate that both WW domains in YAP and TAZ are functional and capable of enhanced affinity binding to multi-PPxY partner proteins such as LATS1, ErbB4, and AMOT.
  25. doi The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases
    William P Ranahan
    Department of Biochemistry and Molecular Biology, University of Indiana School of Medicine, Indianapolis, Indiana 46202 5122, USA
    Cancer Res 71:2203-11. 2011
    ..This study demonstrates that the adaptor protein Amot, in addition to its established role in regulating cellular asymmetry, also promotes extracellular signal-regulated ..
  26. pmc Hippo pathway-independent restriction of TAZ and YAP by angiomotin
    Siew Wee Chan
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    J Biol Chem 286:7018-26. 2011
    ..an independent mechanism for the cell to restrict the activity of TAZ and YAP through interaction with angiomotin (Amot) and angiomotin-like 1 (AmotL1)...
  27. pmc Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
    Bin Zhao
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 25:51-63. 2011
    ..Here we report a novel mechanism of YAP regulation by angiomotin (AMOT) family proteins via a direct interaction...
  28. pmc A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth
    Lars Holmgren
    Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institutet, SE171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:9208-13. 2006
    ..Here, we describe a strategy that targets the angiostatin receptor angiomotin (Amot) by DNA vaccination...
  29. ncbi A new granulation method for compressed tablets [proceedings]
    M H Rubinstein
    J Pharm Pharmacol 28:67P. 1976
  30. ncbi Protein diversity is generated within the motin family of proteins by alternative pre-mRNA splicing
    Julie Moreau
    Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUL, Laval University, Bloc T1 492705, Boul Laurier, Ste Foy, Quebec, Canada G1V 4G2
    Gene 350:137-48. 2005
    ..The alternative splicing that occurs within this protein family may have important implications in the regulation of the expression and function of the motins...
  31. ncbi Angiomotin expression promotes hemangioendothelioma invasion
    Tetyana Levchenko
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, S 17176, Stockholm, Sweden
    Oncogene 23:1469-73. 2004
    ..Control tubes start to regress after 72 h, whereas MAE-angiomotin (MAE Amot) tubes were stable for over 30 days...
  32. ncbi Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin
    Tetyana Levchenko
    Department of Oncology Pathology, Cancer Center Karolinska Institutet, S 17176 Stockholm, Sweden
    J Cell Sci 116:3803-10. 2003
    ..These results suggest that the putative PDZ binding motif of angiomotin plays a critical role in regulating the responsiveness of endothelial cells to chemotactic cues...
  33. ncbi Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains
    Anders Bratt
    Department of Oncology and Pathology, Karolinska Institutet, CCK R8 03 Karolinska Hospital, S 171 76 Stockholm, Sweden
    Gene 298:69-77. 2002
    ..Further phylogenetic analysis indicates that amotl2 is an evolutionary outgroup in relation to angiomotin and amotl1. Northern blot analysis shows distinct expression patterns for each motin in various mouse tissues...
  34. pmc Hold that line. Angiomotin regulates endothelial cell motility
    B R Zetter
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 152:F35-6. 2001
  35. ncbi Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties
    Yuko Sugihara-Mizuno
    Department of Cell Biology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 12:473-86. 2007
    ..Using yeast two-hybrid screening, we found here that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, which we refer to as Amot/JEAP family proteins...
  36. ncbi Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation
    Billie A Moore-Scott
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 236:1997-2003. 2007
    ..We have identified three genes Slc39a8, Amot, and Dp1l1, which are expressed in the visceral endoderm at e7.5. Starting at e9...
  37. ncbi [Analysis of expression profiles of some tumor growth-related genes after silencing of pleiotrophin in human small cell lung cancer H446 cells]
    Yong Yu
    Department of Respiratory Medicine, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
    Zhonghua Zhong Liu Za Zhi 32:405-9. 2010
    To investigate the changes in expression profiles of angiomotin (Amot), schlafen5 (Slfn5), metalloproteinase-9 (MMP-9) and vascular endothelial cell growth factor (VEGF), which are genes associated with angiogenesis, tumor growth and ..
  38. pmc Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain
    Brigitte Heller
    Department of Biochemistry and Molecular Biology, University of Indiana School ofMedicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 285:12308-20. 2010
    ..arrangement for the Par and Crb apical polarity complexes at the tight junction is disrupted by the adaptor protein Amot. Amot directly binds the scaffolding proteins Patj and Mupp1 and redistributes them and their binding partners from ..
  39. doi Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis
    Yujuan Zheng
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Circ Res 105:260-70. 2009
    We have previously shown that angiomotin (Amot) is essential for endothelial cell migration during mouse embryogenesis. However, approximately 5% of Amot knockout mice survived without any detectable vascular defects...
  40. doi Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton
    Valérie Gagné
    Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ CHUL, Department of Anatomy and Physiology, Universite Laval, Boul Laurier, Quebec, Quebec, Canada
    Cell Motil Cytoskeleton 66:754-68. 2009
    ..These findings have important implications for angiogenesis-driven disease since angiomotin and angiomotin-like 1 are both expressed in capillaries...
  41. pmc The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
    Mira Ernkvist
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Blood 113:244-53. 2009
    ..We have previously shown that angiomotin (Amot), a membrane-associated scaffold protein, plays a critical role during vascular patterning and endothelial ..
  42. doi Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells
    Mira Ernkvist
    Cancer Centrum Karolinska, Department of Oncology and Pathology, Karolinska Institutet, CCK R8 03, 171 76 Stockholm, Sweden
    Biochim Biophys Acta 1783:429-37. 2008
    We have previously shown that angiomotin (Amot) plays an important role in growth factor-induced migration of endothelial cells in vitro...
  43. ncbi Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivo
    Tetyana Levchenko
    Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institute, SE 17176, Stockholm, Sweden
    FASEB J 22:880-9. 2008
    We have previously shown that angiomotin (Amot) mediates angiostatin inhibition of endothelial migration and tube formation in vitro...
  44. pmc Angiomotin regulates endothelial cell migration during embryonic angiogenesis
    Karin Aase
    Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Genes Dev 21:2055-68. 2007
    ..We have previously identified angiomotin (Amot) as a receptor for the angiogenesis inhibitor angiostatin...