Gene Symbol: ALYREF
Description: Aly/REF export factor
Alias: ALY, ALY/REF, BEF, REF, THOC4, THO complex subunit 4, THO complex 4, ally of AML-1 and LEF-1, bZIP enhancing factor, bZIP-enhancing factor BEF, tho4, transcriptional coactivator Aly/REF
Species: human
Products:     ALYREF

Top Publications

  1. Guo S, Hakimi M, Baillat D, Chen X, Farber M, Klein Szanto A, et al. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res. 2005;65:3011-6 pubmed
    ..These results not only identify hTREX84 as a prognosticator of breast cancer but also delineate human TREX complex as a target for therapeutic drugs against breast cancer. ..
  2. Cheng H, Dufu K, Lee C, Hsu J, Dias A, Reed R. Human mRNA export machinery recruited to the 5' end of mRNA. Cell. 2006;127:1389-400 pubmed
    ..We show that the human TREX complex is recruited to a region near the 5' end of mRNA, with the TREX component Aly bound closest to the 5' cap...
  3. Sugiura T, Sakurai K, Nagano Y. Intracellular characterization of DDX39, a novel growth-associated RNA helicase. Exp Cell Res. 2007;313:782-90 pubmed
    ..DDX39 tethers ALY, an essential mRNA export factor, in vivo, confirming the role of DDX39 in the RNA splicing/export process...
  4. Nekorchuk M, Han Z, Hsieh T, Swaminathan S. Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export. J Virol. 2007;81:9990-8 pubmed
    ..ORF57 interacts with the cellular export factor REF and with RNA, suggesting that it may provide target mRNAs with access to REF, which mediates nuclear RNA export by ..
  5. Okada M, Jang S, Ye K. Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY. Proc Natl Acad Sci U S A. 2008;105:8649-54 pubmed publisher
    ..b>Aly is a nuclear speckle protein implicated in mRNA export...
  6. Domínguez Sánchez M, Saez C, Japon M, Aguilera A, Luna R. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer. 2011;11:77 pubmed publisher
    ..THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity...
  7. Chang C, Hautbergue G, Walsh M, Viphakone N, van Dijk T, Philipsen S, et al. Chtop is a component of the dynamic TREX mRNA export complex. EMBO J. 2013;32:473-86 pubmed publisher
    ..couples nuclear pre-mRNA processing with mRNA export and contains multiple protein components, including Uap56, Alyref, Cip29 and the multi-subunit THO complex. Here, we have identified Chtop as a novel TREX component...
  8. Luo M, Zhou Z, Magni K, Christoforides C, Rappsilber J, Mann M, et al. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature. 2001;413:644-7 pubmed
    ..During splicing, the conserved mRNA export factor Aly is recruited to the spliced mRNA-protein complex (mRNP), which targets the mRNA for export...
  9. Chen I, Sciabica K, Sandri Goldin R. ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway. J Virol. 2002;76:12877-89 pubmed
    ..leptomycin B (LMB) in HSV-1-infected cells but not in Xenopus oocytes, where ICP27 interacts with the export factor Aly/REF to access the TAP export pathway...

More Information

Publications106 found, 100 shown here

  1. Yoh S, Cho H, Pickle L, Evans R, Jones K. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Genes Dev. 2007;21:160-74 pubmed
    ..protein, hIws1 (interacts with Spt6), and found that it associates with the nuclear RNA export factor, REF1/Aly. Depletion of endogenous hIws1 resulted in mRNA processing defects, lower levels of REF1/Aly at the c-myc gene, and ..
  2. Boyne J, Colgan K, Whitehouse A. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog. 2008;4:e1000194 pubmed publisher
    ..The formation of this vRNP is mediated by a direct interaction between ORF57 and the hTREX export adapter protein, Aly. Aly in turn interacts directly with the DEAD-box protein UAP56, which functions as a bridge to recruit the ..
  3. Dias A, Dufu K, Lei H, Reed R. A role for TREX components in the release of spliced mRNA from nuclear speckle domains. Nat Commun. 2010;1:97 pubmed publisher
    ..When the TREX components UAP56 or Aly are knocked down, spliced mRNA, as well as total polyA+ RNA, accumulates in nuclear speckle domains...
  4. Bruhn L, Munnerlyn A, Grosschedl R. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes Dev. 1997;11:640-53 pubmed
    ..With the aim of gaining insight into the function of context-dependent activation domains, we cloned ALY, a novel LEF-1-interacting protein...
  5. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 2005;19:1512-7 pubmed
  6. Johnson S, Cubberley G, Bentley D. Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11. Mol Cell. 2009;33:215-26 pubmed publisher
    ..These results suggest a mechanism for cotranscriptional assembly of the export competent mRNP and for coordinating export with 3' end processing. ..
  7. Mertz J, Kobayashi R, Dudley J. ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer. J Virol. 2007;81:3503-13 pubmed
    ..enhancer oligomer containing the RUNX1 binding site followed by mass spectrometry resulted in the identification of ALY. Subsequent experiments focused on the reconstitution of enhancer activity in epithelial cells...
  8. Tian X, Devi Rao G, Golovanov A, Sandri Goldin R. The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export. J Virol. 2013;87:7210-7 pubmed publisher
    ..ICP27 also interacts with the mRNA export adaptor protein Aly/REF, which binds cellular mRNAs and also interacts with TAP/NXF...
  9. Le Hir H, Izaurralde E, Maquat L, Moore M. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J. 2000;19:6860-9 pubmed
    ..factors SRm160, DEK and RNPS1, the mRNA-associated shuttling protein Y14 and the mRNA export factor REF. Possible functions for this complex in nucleocytoplasmic transport of spliced mRNA, as well as the nonsense-..
  10. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez Navarro S, et al. TREX is a conserved complex coupling transcription with messenger RNA export. Nature. 2002;417:304-8 pubmed
    ..proteins Yra1 and Sub2 are messenger RNA export factors that have conserved counterparts in metazoans, designated Aly and UAP56, respectively. These factors couple the machineries that function in splicing and export of mRNA...
  11. Pryor A, Tung L, Yang Z, Kapadia F, Chang T, Johnson L. Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56. Nucleic Acids Res. 2004;32:1857-65 pubmed
    ..Both proteins interact with the mRNA export factor Aly and both are able to rescue the loss of Sub2p (the yeast homolog of UAP56), indicating that both proteins have ..
  12. Katahira J, Inoue H, Hurt E, Yoneda Y. Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. EMBO J. 2009;28:556-67 pubmed publisher
    ..Notably, adaptor protein Aly and Thoc5 can simultaneously bind to non-overlapping binding sites on Tap-p15...
  13. Huang J, Wang T, Wright A, Yang J, Zhou S, Li L, et al. Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development. Proc Natl Acad Sci U S A. 2015;112:4447-52 pubmed publisher
    ..The loss of myocardin in SMCs triggers ER stress and autophagy, which transitions to apoptosis, revealing evolutionary conservation of myocardin function in SMCs and cardiomyocytes. ..
  14. Dahmer J, do Carmo G, Mostardeiro M, Neto A, da Silva U, Dalcol I, et al. Antibacterial Activity of Discaria americana Gillies ex Hook (Rhamnaceae). J Ethnopharmacol. 2018;: pubmed publisher
    ..From the fractions obtained from the crude extract, the basic ethereal fraction (BEF) showed to be more effective, with MICs between 31.5 to 125μgmL-1 against the tested bacteria...
  15. Tian L, Li H, Li Y, Liu K, Sun Y, Cong Z, et al. A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats. J Pharmacol Exp Ther. 2018;364:399-408 pubmed publisher
    ..Therefore, the prevention mechanisms of CCS will be further investigated in the future, with a hope of fully understanding of antiadhesion effects. ..
  16. Waldman M, Cohen K, Yadin D, Nudelman V, Gorfil D, Laniado Schwartzman M, et al. Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving 'SIRT1 and PGC-1α'. Cardiovasc Diabetol. 2018;17:111 pubmed publisher
    ..Our results suggest that increasing SIRT1 and PGC-1α levels offer new therapeutic approaches for the protection of the diabetic heart. ..
  17. Okamoto S, Asgar N, Yokota S, Saito K, Minokoshi Y. Role of the α2 subunit of AMP-activated protein kinase and its nuclear localization in mitochondria and energy metabolism-related gene expressions in C2C12 cells. Metabolism. 2019;90:52-68 pubmed publisher
    ..Furthermore, the nuclear translocation of AMPKα2 is necessary for maintenance of PGC-1α1 mRNA during myogenesis. ..
  18. Hung C, Lin C, Chang H, Wang C, Lin S, Hsu P, et al. Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity. J Neurosci. 2016;36:2027-43 pubmed publisher
    ..Hence, astrocytic GAP43 upregulation may serve to indicate beneficial astrogliosis after CNS injury. ..
  19. Knierim E, Hirata H, Wolf N, Morales Gonzalez S, Schottmann G, Tanaka Y, et al. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Am J Hum Genet. 2016;98:473-489 pubmed publisher
    ..Our findings indicate that the dysfunction of a transcriptional coactivator complex can result in a clinical syndrome affecting the neuromuscular system. ..
  20. Lv Y, Kim K, Sheng Y, Cho J, Qian Z, Zhao Y, et al. YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6. Circ Res. 2018;123:43-56 pubmed publisher
  21. Chakravarthi B, Goswami M, Pathi S, Robinson A, Cieślik M, Chandrashekar D, et al. MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer. Oncogene. 2016;35:6330-6340 pubmed publisher
    ..This study therefore demonstrates functional role of SUB1 in prostate cancer, and identifies its regulation and potential downstream therapeutic targets of SUB1 in prostate cancer. ..
  22. Vicente Crespo M, Pascual M, Fernandez Costa J, Garcia Lopez A, Monferrer L, Miranda M, et al. Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis. PLoS ONE. 2008;3:e1613 pubmed publisher
    ..and 13 dominant enhancers including Drosophila CUG-BP1 homolog aret, exon junction complex components tsunagi and Aly, and pro-apoptotic genes Traf1 and reaper...
  23. Chen Q, Li W, Wan Y, Xia X, Wu Q, Chen Y, et al. Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways. Hepatology. 2012;55:1820-9 pubmed publisher
    ..AIB1 served as an essential coactivator for Nrf2 activation by physically interacting with Nrf2 to enhance its transcriptional activity...
  24. Guo L, Ganguly A, Sun L, Suo F, Du L, Russell P. Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast. G3 (Bethesda). 2016;6:3317-3333 pubmed publisher
    ..Notable differences are apparent with corresponding screens in the budding yeast Saccharomyces cerevisiae, underscoring the utility of analyzing toxic metal defense mechanisms in both organisms. ..
  25. Zhang Y, Wang Z, Ding L, Damaolar A, Li Z, Qiu Y, et al. Lentivirus-TAZ Administration Alleviates Osteoporotic Phenotypes in the Femoral Neck of Ovariectomized Rats. Cell Physiol Biochem. 2016;38:283-94 pubmed publisher
    ..Lentivirus-mediated TAZ gene therapy alleviated the osteoporotic phenotypes in the femoral neck of OVX rats, providing an alternative strategy for the treatment of postmenopausal osteoporosis and prevention of osteoporotic fracture. ..
  26. Chi B, Wang Q, Wu G, Tan M, Wang L, Shi M, et al. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Nucleic Acids Res. 2013;41:1294-306 pubmed publisher
    The mRNA export complex TREX (TREX) is known to contain Aly, UAP56, Tex1 and the THO complex, among which UAP56 is required for TREX assembly...
  27. Zhu D, Wang Z, Zhao J, Calimeri T, Meng J, Hideshima T, et al. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat Med. 2015;21:572-80 pubmed publisher
    ..These findings suggest that eCyPA-CD147 signaling promotes the bone marrow homing of B cell malignancies and offer a compelling rationale for exploring this axis as a therapeutic target for these malignancies. ..
  28. Ma J, Brennan K, D Aloia M, Pascuzzi P, Weake V. Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development. G3 (Bethesda). 2016;6:2435-45 pubmed publisher
  29. Luo C, Lim J, Lee Y, Granter S, Thomas A, Vazquez F, et al. A PGC1?-mediated transcriptional axis suppresses melanoma metastasis. Nature. 2016;537:422-426 pubmed publisher
    ..Consequently, components of these circuits define new therapeutic opportunities that may help to curb melanoma metastasis. ..
  30. Zhang M, Ge J, Wen Z, Chen W, Wang X, Liu R, et al. Characterization of a recombinant Newcastle disease virus expressing the glycoprotein of bovine ephemeral fever virus. Arch Virol. 2017;162:359-367 pubmed publisher
    Bovine ephemeral fever (BEF) is caused by the arthropod-borne bovine ephemeral fever virus (BEFV), which is a member of the family Rhabdoviridae and the genus Ephemerovirus...
  31. Colgan K, Boyne J, Whitehouse A. Uncoupling of hTREX demonstrates that UAP56 and hTHO-complex recruitment onto herpesvirus saimiri intronless transcripts is required for replication. J Gen Virol. 2009;90:1455-60 pubmed publisher
    ..nucleocytoplasmic shuttle protein binds viral RNA and interacts with the cellular nuclear export adaptor protein, Aly, to access the TAP-mediated nuclear export pathway...
  32. Taniguchi I, Mabuchi N, Ohno M. HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment. Nucleic Acids Res. 2014;42:6645-58 pubmed publisher
    ..Thus, Rev controls the identity of the factor occupying the cap-proximal region that determines the RNA export pathway. This ribonucleoprotein remodeling activity of Rev may favor viral gene expression. ..
  33. Tang F, Gill J, Ficht X, Barthlott T, Cornils H, Schmitz Rohmer D, et al. The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility. Sci Signal. 2015;8:ra100 pubmed publisher
    ..Together, our findings indicate that the kinases NDR1 and NDR2 function as downstream effectors of MST1 to mediate thymocyte egress and T cell migration. ..
  34. Iezaki T, Fukasawa K, Park G, Horie T, Kanayama T, Ozaki K, et al. Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-?B/NFATc1 Pathway. Mol Cell Biol. 2016;36:2451-63 pubmed publisher
    ..These findings suggest that an Ifrd1/NF-?B/NFATc1 axis plays a pivotal role in bone remodeling in vivo and represents a therapeutic target for bone diseases. ..
  35. Horie M, Saito A, Ohshima M, Suzuki H, Nagase T. YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer. Cancer Sci. 2016;107:1755-1766 pubmed publisher
    ..Our findings shed light on a subtype of SCLC with YAP and TAZ expression, and delineate molecular networks underlying the heterogeneity of SCLC. ..
  36. Barnes A, Jochum M, Lefcheck J, Eisenhauer N, Scherber C, O Connor M, et al. Energy Flux: The Link between Multitrophic Biodiversity and Ecosystem Functioning. Trends Ecol Evol. 2018;33:186-197 pubmed publisher
    ..Yet, there is still no generalised approach to address such complexity in biodiversity-ecosystem functioning (BEF) studies...
  37. Kim V, Kataoka N, Dreyfuss G. Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science. 2001;293:1832-6 pubmed
    ..The mRNA export factors Aly/REF and TAP are also associated with nuclear hUpf3, indicating that hUpf3 is in mRNP complexes that are poised for ..
  38. Yagi H, Asanoma K, Ohgami T, Ichinoe A, Sonoda K, Kato K. GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer. Oncogene. 2016;35:4471-80 pubmed publisher
    ..Furthermore, we reveal that inhibition of YAP by short hairpin RNA or a specific inhibitor prevented the growth of ovarian cancer cells. Therefore, YAP may be a suitable therapeutic target in ovarian cancer. ..
  39. Xiao Z, Baudry J, Cao L, Huang J, Chen H, Yates C, et al. Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis. J Clin Invest. 2018;128:157-174 pubmed publisher
  40. Volk D, Edelson J, Lewis D. Altered expression of developmental regulators of parvalbumin and somatostatin neurons in the prefrontal cortex in schizophrenia. Schizophr Res. 2016;177:3-9 pubmed publisher
  41. Killoran R, Sowole M, Halim M, Konermann L, Choy W. Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition. Protein Sci. 2016;25:1420-9 pubmed publisher
    ..Intriguingly, Cby's C-terminal half alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions. ..
  42. Jayaraman S, Doucet M, Lau W, Kominsky S. CITED2 Modulates Breast Cancer Metastatic Ability through Effects on IKK?. Mol Cancer Res. 2016;14:730-9 pubmed publisher
    ..The current study highlights the role of CITED2 in facilitating breast cancer metastasis, partly via regulation of IKK?. Mol Cancer Res; 14(8); 730-9. ©2016 AACR. ..
  43. Yu H, Zhao Z, Yu X, Li J, Lu C, Yang R. Bovine lipid metabolism related gene GPAM: Molecular characterization, function identification, and association analysis with fat deposition traits. Gene. 2017;609:9-18 pubmed publisher
    ..adipogenesis was examined in vitro by RNAi and gene expression to silencing and over-expression of GPAM gene in BEF cells...
  44. Souki S, Sandri Goldin R. Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection. J Virol. 2009;83:8970-5 pubmed publisher
    ..therefore, we examined the effect of hypomethylation on ICP27's interactions with cellular proteins SRPK1 and Aly/REF, which bind to ICP27 through the RGG box region...
  45. Zhang J, Yuan S, Vasilyev A, Amin Arnaout M. The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish. Mech Dev. 2015;138 Pt 3:328-35 pubmed publisher
  46. Saito A, Nagase T. Hippo and TGF-β interplay in the lung field. Am J Physiol Lung Cell Mol Physiol. 2015;309:L756-67 pubmed publisher
    ..In this review, we summarize the current knowledge of the Hippo pathway regarding lung development and diseases, with an emphasis on its interplay with TGF-β signaling. ..
  47. Monroe N, Han H, Shen P, Sundquist W, Hill C. Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. elife. 2017;6: pubmed publisher
    ..We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1, ADP·BeFx, and an ESCRT-III substrate peptide...
  48. Shi M, Zhang H, Wu X, He Z, Wang L, Yin S, et al. ALYREF mainly binds to the 5' and the 3' regions of the mRNA in vivo. Nucleic Acids Res. 2017;45:9640-9653 pubmed publisher
    ..We used individual cross-linking and immunoprecipitation (iCLIP) to identify the binding sites of ALYREF, an mRNA export adaptor in TREX, in human cells...
  49. Dhanasekaran K, Kumari S, Boopathi R, Shima H, Swaminathan A, Bachu M, et al. Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes. FEBS J. 2016;283:968-85 pubmed publisher
    ..Similarly, the PC4 phosphodeficient mutant failed to rescue such defects. Hence, our observations establish a novel mitotic function of PC4 that might be dependent on Aurora kinase-mediated phosphorylation. ..
  50. Kasetti R, Gaddipati S, Tian S, Xue L, Kao W, Lu Q, et al. Study of corneal epithelial progenitor origin and the Yap1 requirement using keratin 12 lineage tracing transgenic mice. Sci Rep. 2016;6:35202 pubmed publisher
  51. Dinulovic I, Furrer R, Di Fulvio S, Ferry A, Beer M, Handschin C. PGC-1? modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skelet Muscle. 2016;6:38 pubmed
    ..PGC-1? exerts beneficial effects on muscle inflammation that might contribute to the therapeutic effects of elevated muscle PGC-1? in different models of muscle wasting. ..
  52. Chen W, Lü X, Chen Y, Li M, Mo P, Tong Z, et al. Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression. J Immunol. 2017;198:1606-1615 pubmed publisher
    ..Collectively, we show that SRC-3 contributes to host defense against enteric bacteria, at least in part via upregulating CXCL2 expression to recruit neutrophils. ..
  53. Pettersson Klein A, Izadi M, Ferreira D, Cervenka I, Correia J, Martínez Redondo V, et al. Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration. Mol Metab. 2018;9:28-42 pubmed publisher
    ..This screening platform establishes the foundation for a new class of therapeutics with potential use in obesity and associated disorders. ..
  54. Virbasius C, Wagner S, Green M. A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins. Mol Cell. 1999;4:219-28 pubmed
    ..We show that this bZIP enhancing factor (BEF) functions as a molecular chaperone...
  55. Lochmann T, Thomas R, Bennett J, Taylor S. Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice. PLoS ONE. 2015;10:e0129647 pubmed publisher
    ..Together, these data show that epigenetic modifications partially explain exercise-induced changes in the skeletal muscle mRNA levels of PGC-1α isoforms. ..
  56. Chen T, Chen C, Wen H, Chang C, Wang H, Chuu C, et al. YAP promotes myogenic differentiation via the MEK5-ERK5 pathway. FASEB J. 2017;31:2963-2972 pubmed publisher
    ..Chen, T.-H., Chen, C.-Y., Wen, H.-C., Chang, C.-C., Wang, H.-D., Chuu, C.-P., Chang, C.-H. YAP promotes myogenic differentiation via the MEK5-ERK5 pathway. ..
  57. Martini A, Marioni G, Zanoletti E, Cappellesso R, Stramare R, Fasanaro E, et al. YAP, TAZ and AREG expression in eighth cranial nerve schwannoma. Int J Biol Markers. 2017;32:e319-e324 pubmed publisher
    ..Further investigations are needed to identify the biological factors influencing tumor proliferation (ideally secreted proteins like AREG) that might be detected using non-invasive approaches (i.e., blood samples). ..
  58. Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, et al. ALY as a potential contributor to metastasis in human oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2013;139:585-94 pubmed publisher
    b>ALY, an essential mRNA export factor, is dysregulated in a wide variety of human malignancies. However, little is known about the relevance of ALY to oral squamous cell carcinoma (OSCC)...
  59. Zhou J, Wei F, Ma Y. Inhibiting PPAR? by erythropoietin while upregulating TAZ by IGF1 synergistically promote osteogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2016;478:349-355 pubmed publisher
  60. Yang B, Sun H, Song F, Wu Y, Wang J. Yes-associated protein 1 promotes the differentiation and mineralization of cementoblast. J Cell Physiol. 2018;233:2213-2224 pubmed publisher
    ..Thus, our study suggested that YAP1 enhanced cementoblast mineralization in vitro. YAP1 exerted its effect on the cementoblast partly by regulating the Smad-dependent BMP and Erk1/2 signaling pathways. ..
  61. Liang M, Yu M, Xia R, Song K, Wang J, Luo J, et al. Yap/Taz Deletion in Gli+ Cell-Derived Myofibroblasts Attenuates Fibrosis. J Am Soc Nephrol. 2017;28:3278-3290 pubmed publisher
    ..Identifying mechanisms that interrupt this profibrotic cycle could lead to the development of anti-fibrosis therapy. ..
  62. Cai Y, Ma W, Xiao Y, Wu B, Li X, Liu F, et al. High doses of baicalin induces kidney injury and fibrosis through regulating TGF-?/Smad signaling pathway. Toxicol Appl Pharmacol. 2017;333:1-9 pubmed publisher
    ..Our results may contribute to better understanding of the future pharmacological and toxicological studies of Scutellaria baicalensis Georgi and its active compounds on the human disease. ..
  63. Liu L, Li G, Wang Y, Wang Y, Li T, Zhang T, et al. A photovoltaic self-powered gas sensor based on a single-walled carbon nanotube/Si heterojunction. Nanoscale. 2017;9:18579-18583 pubmed publisher
    ..The energy from visible light suffices to drive the device owing to a built-in electric field (BEF) induced by the differences between the Fermi levels of SWNTs and n-Si.
  64. Shekar M, Venugopal M. Insight into a Transcriptional Adaptor Zinc Finger Encoded by a Putative Protein in the White Spot Syndrome Virus Genome. Interdiscip Sci. 2019;11:145-151 pubmed publisher
  65. Novak J, Fabrik I, Linhartova I, Link M, Cerny O, Stulik J, et al. Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells. Sci Rep. 2017;7:16298 pubmed publisher
    ..These findings document the complexity of subversive physiological manipulation of myeloid phagocytes by the CyaA toxin, serving in immune evasion of the pertussis agent. ..
  66. Rubio M, Pardal A, Cardoza R, Gutierrez S, Monte E, Hermosa R. Involvement of the Transcriptional Coactivator ThMBF1 in the Biocontrol Activity of Trichoderma harzianum. Front Microbiol. 2017;8:2273 pubmed publisher
    ..Our results show that the Thmbf1 overexpression in T34 negatively affects its biocontrol mechanisms...
  67. Dutta R, Tiu B, Sakamoto K. CBP/p300 acetyltransferase activity in hematologic malignancies. Mol Genet Metab. 2016;119:37-43 pubmed publisher
    ..Understanding the effects of disrupting the acetyltransferase activity of CBP/p300 could pave the way for new therapeutic approaches to treat patients with these diseases. ..
  68. Kurosawa M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Sprent J, et al. NF-?B2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in a Mouse Model of Sjögren's Syndrome. Arthritis Rheumatol. 2017;69:2193-2202 pubmed publisher
    ..role of the potent chemokine CXCL12 and its receptor CXCR4 in the T cell autoimmune response, using alymphoplasia (aly)/aly mice, a model of Sjögren's syndrome (SS)...
  69. Hertig V, Matos Nieves A, Garg V, Villeneuve L, Mamarbachi M, Caland L, et al. Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis. J Cell Physiol. 2018;233:3218-3229 pubmed publisher
    ..Based on these data, an analogous role of Yap-1 may be prevalent in the heart of Tbx5+/- and Gata4+/- mice. ..
  70. Yue J, Lai F, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Genes Dev. 2017;31:1809-1820 pubmed publisher
    ..We propose Integrator as a crucial transcriptional coactivator in MAPK signaling, which could serve as a downstream therapeutic target for cancer treatment. ..
  71. Vandenbeek R, Khan N, Estall J. Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism. Endocrinology. 2018;159:853-865 pubmed publisher
  72. Corbin Lickfett K, Rojas S, Li L, Cocco M, Sandri Goldin R. ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNA. J Virol. 2010;84:2212-22 pubmed publisher
    ..impaired, we analyzed the subcellular localization of ICP27 and its colocalization with cellular RNA export factors Aly/REF and TAP/NXF1...
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    ..By linking IKKβ-mediated nuclear factor-κB activity with GLI1, we identified a crosstalk between these 2 pathways that can inform the design of novel therapeutic strategies in DLBCL. ..
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    ..The findings here suggest that an age-related increase in muscle stiffness drives YAP/TAZ-mediated pathogenic expression of matricellular proteins by fibroblasts, ultimately disrupting MuSC fate...
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    ..Our results highlight RAC/PAK1 as major players in YAP1 regulation triggered by cell adhesion. ..
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    Biodiversity-ecosystem function (BEF) experiments routinely employ common garden designs, drawing samples from a local biota. The communities from which taxa are sampled may not, however, be at equilibrium...
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    ..Our results demonstrate a pivotal role for TAZ in regulating the differentiation of Treg cells and TH17 cells. ..
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    ..We show that the nuclear protein ALY (THO complex 4), originally described as a transcriptional co-activator, associates with DNA-bound E2F2 and represses its ..
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    ..Our findings offer a preclinical proof of concept for small-molecule therapies to target the CBP/p300 bromodomain as a strategy to treat castration-resistant prostate cancer. Cancer Res; 77(20); 5564-75. ©2017 AACR. ..
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    Experiments have shown positive biodiversity-ecosystem functioning (BEF) relationships in small plots with model communities established from species pools typically comprising few dozen species...
  83. Johnson L, Li L, Sandri Goldin R. The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable. J Virol. 2009;83:6335-46 pubmed publisher
    ..ICP27 was found to interact with the cellular RNA export adaptor protein Aly/REF, which is part of the TREX complex, and to relocalize Aly/REF to viral replication sites...
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    ..These observations indicate that non-histone chromatin-associated proteins like PC4 play a significant role in neuronal plasticity. ..
  85. Wichmann I, Garcia Lozano J, Respaldiza N, Gonzalez Escribano M, Nunez Roldan A. Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus. Hum Immunol. 1999;60:57-62 pubmed
    ..transduction and transcriptional regulation, and a novel 28 kD protein that showed a 94% homology with murine ALY, a nuclear protein that plays a role in regulating the activity of TCRalpha enhancer complex...
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    ..of this protein family and play an essential role for cellular mRNA export by recruiting the adaptor protein REF to spliced and unspliced mRNAs...
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    ..FLIM)-FRET, to produce a spatial map in living cells of the sites for the interaction of two TREX subunits, Alyref and Chtop, with Nxf1...
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    ..SRC-3 overexpression is clinically and functionally relevant to the progression of human ESCC, and might be a useful molecular target for ESCC prognosis and treatment. ..
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    ..These findings provide novel insights into the molecular mechanism of PODXL-mediated tumorigenesis in colon cancer. ..
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    ..This multicellular network could allow the development of novel and specific perturbation approaches. ..
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    ..Moreover, we found that pressure regulation may be more effective on YAP from cancer cells as compared to normal cells, which could help open a door to target YAP for anticancer drug design. ..
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    This laboratory study investigated the parameters efficiency of the new technology: ballasted electro-flocculation (BEF) using aluminum (Al) electrodes to remove cadmium and zinc from industrial mining wastewater (MWW)...