alpha fetoprotein

Summary

Gene Symbol: alpha fetoprotein
Description: alpha-fetoprotein
Alias: FETA, HPAFP, alpha-1-fetoprotein, alpha-fetoglobulin
Species: human

Top Publications

  1. ncbi Primary structures of human alpha-fetoprotein and its mRNA
    T Morinaga
    Proc Natl Acad Sci U S A 80:4604-8. 1983
  2. ncbi Alpha-fetoprotein impairs APC function and induces their apoptosis
    Soon Ho Um
    Institute of Hepatology, University College London, United Kingdom
    J Immunol 173:1772-8. 2004
  3. ncbi Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc
    Nathalie M Mazure
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, CNRS UPR 9078, 92190 Meudon Bellevue, France
    Cancer Res 62:1158-65. 2002
  4. ncbi The refolding of different alpha-fetoprotein variants
    Susanna S J Leong
    Centre for Biomolecular Engineering, The University of Queensland, St Lucia, Australia
    Protein Sci 15:2040-50. 2006
  5. ncbi Immunoelectrophoretic differentiation of alpha-fetoprotein in disorders with elevated serum alpha-fetoprotein levels or during pregnancy
    R J Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei
    Acta Oncol 34:931-5. 1995
  6. ncbi Targeted chemotherapy for unresectable primary and metastatic liver cancer
    T Konno
    First Department of Surgery, Kumamoto University School of Medicine, Japan
    Acta Oncol 33:133-7. 1994
  7. ncbi Serum tumor markers for detection of bone metastasis in breast cancer patients
    A Aydiner
    Dept. of Medical Oncology, Istanbul Faculty of Medicine, Turkey
    Acta Oncol 33:181-6. 1994
  8. ncbi 240 hepatocellular carcinomas: ultrasound features, tumor size, cytologic and histologic patterns, serum alpha-fetoprotein and HBs Ag
    T Livraghi
    Servizio di Radiologia, Ospedale Civile, Vimercate, Italia
    Tumori 73:507-12. 1987
  9. ncbi Primary mediastinal malignant germ cell tumour. Single institution experience in Chinese patients and correlation with specific alpha-fetoprotein bends
    A T Chan
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Acta Oncol 35:221-7. 1996
  10. ncbi Simultaneous determination of alpha-fetoprotein and carcinoembryonic antigen in human serum by time-resolved fluoroimmunoassay
    K Matsumoto
    Department of Chemistry, Waseda University, Shinjuku ku, Japan Science and Technology Corporation, Tokyo, 169 8555, Japan
    Anal Biochem 276:81-7. 1999

Research Grants

  1. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
  2. CHARACTERIZATION OF VITAMIN D BINDING PROTEIN GENES
    Nancy Cooke; Fiscal Year: 1993
  3. Pregnancy Hormonal Profile/Biomarker Breast Cancer Risk
    Alan Arslan; Fiscal Year: 2004
  4. In Vitro Reconstitution of Alpha Fetroprotein Regulation
    Michelle Barton; Fiscal Year: 2007
  5. RETINOIC ACID RECEPTOR, ALPHA-FETOPROTEIN, AND HEPATOMA
    YU JUI WAN; Fiscal Year: 2003
  6. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2007
  7. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN SINGH MONGA; Fiscal Year: 2010
  8. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2009
  9. IN VITRO RECONSTITUTION OF ALPHA FETOPROTEIN REGULATION
    Michelle Barton; Fiscal Year: 2003
  10. Genetic Immunotherapy for Hepatocellular Cancer
    James Economou; Fiscal Year: 2004

Detail Information

Publications180 found, 100 shown here

  1. ncbi Primary structures of human alpha-fetoprotein and its mRNA
    T Morinaga
    Proc Natl Acad Sci U S A 80:4604-8. 1983
    ..Again, the similarity was the highest in domain 3 and the lowest in domain 1. Human AFP and human albumin are similar in overall structure, but certain parts of the molecules differ significantly in their predicted secondary structure...
  2. ncbi Alpha-fetoprotein impairs APC function and induces their apoptosis
    Soon Ho Um
    Institute of Hepatology, University College London, United Kingdom
    J Immunol 173:1772-8. 2004
    ..In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control...
  3. ncbi Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc
    Nathalie M Mazure
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, CNRS UPR 9078, 92190 Meudon Bellevue, France
    Cancer Res 62:1158-65. 2002
    ..Taken together, these results suggest the existence of a possible competition between HIF-1 and c-Myc that could modulate the transcriptional activity of the afp gene in response to hypoxia...
  4. ncbi The refolding of different alpha-fetoprotein variants
    Susanna S J Leong
    Centre for Biomolecular Engineering, The University of Queensland, St Lucia, Australia
    Protein Sci 15:2040-50. 2006
    ....
  5. ncbi Immunoelectrophoretic differentiation of alpha-fetoprotein in disorders with elevated serum alpha-fetoprotein levels or during pregnancy
    R J Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei
    Acta Oncol 34:931-5. 1995
    ..Chronic hepatitis had a light L1 band and a pronounced L3 band. In pregnancy, the AFP pattern is similar to that of hepatocellular carcinoma. Immunoelectrophoresis is a useful method facilitating the differentiation of AFP origins...
  6. ncbi Targeted chemotherapy for unresectable primary and metastatic liver cancer
    T Konno
    First Department of Surgery, Kumamoto University School of Medicine, Japan
    Acta Oncol 33:133-7. 1994
    ..In the 110 patients with metastatic liver cancer, the carcinoembryonic antigen level and tumor size were reduced. The 1-, 2-, and 5-year survival rates of these 110 patients were 61, 32, and 22% respectively...
  7. ncbi Serum tumor markers for detection of bone metastasis in breast cancer patients
    A Aydiner
    Dept. of Medical Oncology, Istanbul Faculty of Medicine, Turkey
    Acta Oncol 33:181-6. 1994
    ..It is concluded that monitoring with combinations of tumor markers at regular intervals increases the diagnostic efficiency...
  8. ncbi 240 hepatocellular carcinomas: ultrasound features, tumor size, cytologic and histologic patterns, serum alpha-fetoprotein and HBs Ag
    T Livraghi
    Servizio di Radiologia, Ospedale Civile, Vimercate, Italia
    Tumori 73:507-12. 1987
    ..Since the discovery of a small HCC is an incidental ultrasonographic finding in the context of severe liver disease, ultrasonographic monitoring of cirrhotic patients is the best available strategy to screen for small HCC...
  9. ncbi Primary mediastinal malignant germ cell tumour. Single institution experience in Chinese patients and correlation with specific alpha-fetoprotein bends
    A T Chan
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Acta Oncol 35:221-7. 1996
    ..In each case the change in NSGCT-specific AFP concentration in response to therapy closely paralleled that of total AFP. Estimation of NSGCT-specific AFP offers no apparent advantage in monitoring disease response or progression...
  10. ncbi Simultaneous determination of alpha-fetoprotein and carcinoembryonic antigen in human serum by time-resolved fluoroimmunoassay
    K Matsumoto
    Department of Chemistry, Waseda University, Shinjuku ku, Japan Science and Technology Corporation, Tokyo, 169 8555, Japan
    Anal Biochem 276:81-7. 1999
    ..A good correlation was obtained with the correlation coefficients of 0.990 for AFP and 0.973 for CEA...
  11. ncbi Clinical characteristics among patients with hepatocellular carcinoma according to the serum levels of alpha-fetoprotein and des-y-carboxy prothrombin
    Kazufumi Dohmen
    Clinical Research Center, National Nagasaki Medical Center, Nagasaki 856 8562, Japan
    Hepatogastroenterology 50:2072-8. 2003
    ..In the current study we investigated the different clinical variables in patients with hepatocellular carcinoma according to the serum levels of AFP and DCP...
  12. ncbi Maternal smoking: age distribution, levels of alpha-fetoprotein and human chorionic gonadotrophin, and effect on detection of Down syndrome pregnancies in second-trimester screening
    J A Crossley
    Institute of Medical Genetics, Yorkhill NHS Trust, Glasgow, G3 8SJ, UK
    Prenat Diagn 22:247-55. 2002
    ....
  13. ncbi [Melanoma antigen-3 expression in human hepatocellular carcinoma]
    S Cai
    Department of Surgery, People's Hospital, Beijing University, Beijing 100044, China
    Zhonghua Wai Ke Za Zhi 38:693-6. 2000
    ..The phenomena that some non-HCC adjacent tissues with heteromorphism can express MAGE-3 like their paired HCC tissues indicate that the expression of MAGE-3 may be an indicator in the early stage of carcinogenesis of liver tissues...
  14. ncbi Alterations of glycan branching and differential expression of sialic acid on alpha fetoprotein among hepatitis patients
    Gautam Mondal
    Department of School of Management and Science, West Bengal University of Technology, Salt Lake, Kolkata, 700064, India
    Glycoconj J 28:1-9. 2011
    ..Some of them, especially alpha fetoprotein (AFP), serve as useful biomarkers for HCC...
  15. ncbi Flavonoids inhibit estrogen binding to rat alpha-fetoprotein
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    Proc Soc Exp Biol Med 217:317-21. 1998
    ..Finally, bioflavonoids should be useful tools for understanding the variety of estrogen actions initiated by different structural classes of estrogens...
  16. ncbi Circulating AFP mRNA as a Possible Indicator of Hematogenous Spread of HCC Cells: A Possible Association with HBV Infection
    Laila M Montaser
    The Departments of Clinical Pathology, Faculty of Medicine, Menofeya University
    J Egypt Natl Canc Inst 19:48-60. 2007
    Background: Circulating alpha fetoprotein messenger RNA (AFP mRNA) has been proposed as a marker of hepatocellular carcinoma (HCC) cells disseminated into the circulation...
  17. ncbi [The effect of a mixture of tegafur with uracil (UFT) on hepatocarcinogenesis in rats induced by 3'-methyl-4-dimethylaminoazobenzene. I. The influence on production of alpha-fetoprotein]
    H Hirai
    Tumor Laboratory, Tokyo
    Gan To Kagaku Ryoho 15:101-8. 1988
    ..These results show that if the administration of UFT was commenced at the same time with feeding 3'-MeDAB diet, the hepatocarcinogenesis and AFP production are strongly inhibited...
  18. ncbi Reference intervals for serum alpha-fetoprotein and carcinoembryonic antigen in Chinese Han ethnic males from the Fangchenggang Area Male Health and Examination Survey
    Xue Qin
    Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
    Int J Biol Markers 26:65-71. 2011
    ..We calculated upper 95% reference limits for serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) according to the CLSI/NCCLS C28-A3 guideline...
  19. ncbi Clinicopathologic features of patients with intrahepatic cholangiocarcinoma who are seropositive for alpha-fetoprotein-L3 and those with combined hepatocellular and cholangiocarcinoma
    Hiroaki Okuda
    Institute of Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    J Gastroenterol Hepatol 21:869-73. 2006
    ..Thus, the purpose of the present paper was to compare the features of ICC patients from the viewpoint of two different tumor markers, AFP-L3 and carbohydrate antigen (CA) 19-9...
  20. ncbi Lectin-reactive alpha-fetoprotein as a marker for testicular tumor activity
    Koji Kawai
    University of Tsukuba, Institute of Clinical Medicine, Department of Urology, Tsukuba, Ibaraki, Japan
    Int J Urol 12:284-9. 2005
    ..In the present study, we used the subfraction profile of LCA-binding AFP to diagnose and monitor testicular tumor activity...
  21. ncbi [Quantitation of alpha-fetoprotein messenger RNA in peripheral blood of nude mice and its relationship with tumor recurrence and metastasis after curative resection of hepatocellular carcinoma]
    Xiaofeng Wu
    Liver Cancer Institute, Fudan University, Shanghai 200032, China
    Zhonghua Gan Zang Bing Za Zhi 10:189-91. 2002
    ..To assess the level of alpha-fetoprotein (AFP) messenger RNA (mRNA) in peripheral blood of nude mice, and to study its relationship with tumor recurrence and metastasis after curative resection of hepatocellular carcinoma (HCC)...
  22. ncbi Development of high-performance magnetic chemiluminescence enzyme immunoassay for alpha-fetoprotein (AFP) in human serum
    Xu Wang
    The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China
    Clin Chim Acta 393:90-4. 2008
    ....
  23. ncbi The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells
    Meng Sen Li
    Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing, China
    Cell Res 12:151-6. 2002
    ..The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated...
  24. ncbi AFP-L3 in chronic liver diseases with persistent elevation of alpha-fetoprotein
    Hau Tsai Cheng
    Liver Research Unit, Chang Gung Memorial Hospital, Taoyuan, Taiwan, R O C
    J Chin Med Assoc 70:310-7. 2007
    ..However, persistent elevation of AFP is found in patients with chronic liver diseases. The value of AFP-L3, which is more specific than AFP, was examined in such patients...
  25. ncbi Biochemical screening for chromosomal disorders and neural tube defects (NTD): is adjustment of maternal alpha-fetoprotein (AFP) still appropriate in insulin-dependent diabetes mellitus (IDDM)?
    U Sancken
    Institut fur Humangenetik, Universitat Gottingen, Gottingen, Germany
    Prenat Diagn 21:383-6. 2001
    ..It is concluded that progress in insulin adjustment and blood glucose surveillance of diabetic patients on the whole has balanced out serum levels. Therefore adjustment of serum AFP values for diabetic status no longer seems reasonable...
  26. ncbi Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study
    Yoshiaki Kinoshita
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pediatr Hematol Oncol 30:447-50. 2008
    ..However, there are few reports dealing with various pediatric malignant tumors. In the current study, we analyzed the diagnostic value of AFP fractions for pediatric diseases, in particular, those occurring in the neoinfantile period...
  27. ncbi Quantitation of alpha-fetoprotein messenger RNA for early detection of recurrent hepatocellular carcinoma: a prospective pilot study
    H Schmilovitz-Weiss
    Tel Aviv University, Rabin Medical Center, Sackler School of Medicine, Gastroenterology Unit, Hasharon Golda Campus, Petah Tiqwa, Tel Aviv 49372, Israel
    Cancer Detect Prev 30:204-9. 2006
    ..The aim of this prospective pilot study was to assess the prognostic value of quantitative levels of AFP mRNA in patients undergoing ablative treatment for HCC...
  28. ncbi Clinicopathologic features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein-L3 and seronegative for des-gamma-carboxy prothrombin in comparison with those seropositive for des-gamma-carboxy prothrombin alone
    Hiroaki Okuda
    Institute of Gastroenterology, Tokyo Women s Medical University, Japan
    J Gastroenterol Hepatol 17:772-8. 2002
    ..Thus, the present comparative study was performed...
  29. ncbi Alpha-fetoprotein and prognosis in acute liver failure
    Frank V Schiødt
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Liver Transpl 12:1776-81. 2006
    ..In this large prospective study, higher absolute values of AFP did not predict a favorable outcome, but a rising level of AFP over the first 3 hospital days frequently indicated survival...
  30. ncbi Sugar chains of human cord serum alpha-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas
    K Yamashita
    Department of Biochemistry, Sasaki Institute, Tokyo, Japan
    Cancer Res 53:2970-5. 1993
    ....
  31. ncbi Clinical evaluation of lentil lectin-reactive alpha-fetoprotein-L3 in histology-proven hepatocellular carcinoma
    V V Khien
    Department of Hepatology, Central Tran Hung Dao Hospital, Hanoi, Vietnam
    Int J Biol Markers 16:105-11. 2001
    ....
  32. ncbi Clinical implications of alpha-fetoprotein in chronic hepatitis C
    Wei Chen Tai
    Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Formos Med Assoc 108:210-8. 2009
    ..Alpha-fetoprotein (AFP) is important in the diagnosis of HCC, but elevated AFP levels have also been observed in CHC without HCC. We evaluated the clinical correlation between elevated AFP levels and CHC...
  33. ncbi Serum alpha-fetoprotein level per tumor volume reflects prognosis in patients with hepatocellular carcinoma after curative hepatectomy
    Tadashi Furihata
    Department of Gastroenterological Surgery, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Hepatogastroenterology 55:1705-9. 2008
    ..This study aimed to assess the prognostic reliability of serum AFP levels per tumor volume (AFP/volume) after curative resection...
  34. ncbi Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Aichi 470 1192, Japan
    Oncol Rep 16:721-7. 2006
    ..S-1, a fluoropyrimidine containing a strong DPD inhibitor, may be effective for AFP-positive gastric cancers with poorly differentiated medullary growth pattern...
  35. ncbi Lens culinaris agglutinin-reactive alpha-fetoprotein and protein induced by vitamin K absence II are potential indicators of a poor prognosis: a histopathological study of surgically resected hepatocellular carcinoma
    Hisamitsu Miyaaki
    Department of Pathology and Research Center of Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University School of Medicine, Kurume, Japan
    J Gastroenterol 42:962-8. 2007
    ....
  36. ncbi Clinical evaluation of serum alpha-fetoprotein and circulating immune complexes as tumour markers of hepatocellular carcinoma
    J F Tsai
    Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China
    Br J Cancer 72:442-6. 1995
    ..Determination of 3% PEG-CICs should be performed in cirrhotics negative for AFP to improve detection of HCC...
  37. ncbi Structures of disease-specific serum alpha-fetoprotein isoforms
    P J Johnson
    Department of Clinical Oncology, Chinese University of Hong Kong, Shatin, Hong Kong
    Br J Cancer 83:1330-7. 2000
    ..Knowledge of the structure of the tumour-specific isoforms should form an important basis for clinically useful assays...
  38. ncbi Serum alpha-fetoprotein response as a surrogate for clinical outcome in patients receiving systemic therapy for advanced hepatocellular carcinoma
    Sadhna R Vora
    Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts 02114, USA
    Oncologist 14:717-25. 2009
    ..The role of serum alpha-fetoprotein (AFP) as a marker for treatment response in patients with hepatocellular carcinoma (HCC) receiving systemic therapy is poorly defined...
  39. ncbi Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family
    Gerald J Mizejewski
    Wadsworth Center, Division of Translational Medicine, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
    Tumour Biol 32:241-58. 2011
    ..Present data do not support the concept that the AFP receptor is a "universal" tumor receptor and/or biomarker...
  40. ncbi Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alpha-fetoprotein knockout mice: prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges
    David González-Martínez
    Research Group in Behavioral Neuroendocrinology, Center for Cellular and Molecular Neurobiology, University of Liege, Avenue de l Hopital, 4000 Sart Tilman Liège, Belgium
    Endocrinology 149:2333-40. 2008
    ....
  41. ncbi Usefulness of the novel oncofetal antigen glypican-3 for diagnosis of hepatocellular carcinoma and melanoma
    Tetsuya Nakatsura
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    BioDrugs 19:71-7. 2005
    ..Thus, GPC3 is useful for diagnosis of HCC and melanoma and may also have a role in immunotherapy or tumor prevention. However, studies in humans are warranted...
  42. ncbi Highly enhanced fucosylation of alpha-fetoprotein in patients with germ cell tumor
    Y Aoyagi
    Department of Internal Medicine, Niigata University School of Medicine, Japan
    Cancer 72:615-8. 1993
    ..CONCLUSIONS. The current study indicates that the most characteristic feature of glycosylation of AFP in germ cell tumors is fucosylation rather than glucosaminylation...
  43. ncbi An intensive surveillance program detected a high incidence of hepatocellular carcinoma among hepatitis B virus carriers with abnormal alpha-fetoprotein levels or abdominal ultrasonography results
    Tony S K Mok
    Department of Clinical Oncology, Prince of Wales Hospital, School of Public Health, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Oncol 23:8041-7. 2005
    ..To study the incidence and treatment outcomes of hepatocellular carcinoma (HCC) detected in an intensive surveillance program (ISP) of hepatitis B virus (HBV) carriers...
  44. ncbi Alpha-fetoprotein-specific transfer factors downregulate alpha-fetoprotein expression and specifically induce apoptosis in Bel7402 alpha-fetoprotein-positive hepatocarcinoma cells
    Hui Zhang
    School of Life Science, Shandong University, Jinan, China
    Hepatol Res 37:557-67. 2007
    ..Conclusion: AFP-TF induced Bel7402 cells apoptosis is mitochondrial-dependent and is mediated by the interaction of AFP-TF with intracellular AFP...
  45. ncbi The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population
    Apinya Leerapun
    Miles and Shirley Fiterman Center for Digestive Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:394-402; quiz 267. 2007
    ..We evaluated the utility of AFP-L3% for diagnosis of HCC in a US referral population...
  46. ncbi Clinicopathologic features of gastric cancers producing alpha-fetoprotein
    Koji Kono
    First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan
    Dig Surg 19:359-65; discussion 365. 2002
    ..The purpose of the present study was to clarify the clinicopathological features of AFP-producing gastric cancers, in particular characteristics of liver metastasis, and to evaluate treatment of these cancers...
  47. ncbi Biological aggressiveness of alpha-fetoprotein (AFP)-positive gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 53:338-41. 2006
    ..However, little information regarding the clinicopathological and biological behaviors of APGC is available due to the small size of reported series...
  48. ncbi [Lectin-reactive alpha-fetoprotein in tyrosinaemia type I]
    U Baumann
    Universitätskinderklinik Essen, Abteilung für Allgemeine Kinderheilkunde mit Schwerpunkt Neuropädiatrie
    Klin Padiatr 217:142-6. 2005
    ..Lectin-reactive alpha-Fetoprotein is a recently described marker to distinguish hepatocellular carcinoma from benign liver disease in adult cirrhotic patients...
  49. ncbi Simultaneous determination of percentage of Lens culinaris agglutinin-reactive alpha-fetoprotein and alpha-fetoprotein concentration using the LiBASys clinical auto-analyzer
    Yukari Yamagata
    Osaka Research Laboratories, Wako Pure Chemical Industries, Ltd, 6 1 Takada cho, Amagasaki, Hyogo 661 0963, Japan
    Clin Chim Acta 327:59-67. 2003
    ....
  50. ncbi A case of alpha-fetoprotein-producing adenocarcinoma of the endometrium with a hepatoid component as a potential source for alpha-fetoprotein in a postmenopausal woman
    K Takeuchi
    Department of Obstetrics and Gynecology, Hyogo Prefectural Tsukaguchi Hospital, 6 8 17 Minami tsukaguchicho, Amagasaki 661 0012, Japan
    Int J Gynecol Cancer 16:1442-5. 2006
    ....
  51. ncbi Lectin-reactive alpha-fetoprotein in patients with tyrosinemia type I and hepatocellular carcinoma
    Ulrich Baumann
    Children s Hospital, University of Essen, Essen, Germany
    J Pediatr Gastroenterol Nutr 43:77-82. 2006
    ..Lectin-affinity electrophoresis may have a role in discriminating benign liver disease from HCC in HT1. We suggest the further evaluation of L3-AFP in HT1...
  52. ncbi Alpha-fetoprotein as a tumor marker in hepatocellular carcinoma: investigations in south Indian subjects with hepatotropic virus and aflatoxin etiologies
    Kailapuri G Murugavel
    Infectious Diseases Laboratory, YRG Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai 600 113, India
    Int J Infect Dis 12:e71-6. 2008
    ..We verified the usefulness of alpha-fetoprotein (AFP) as a tumor marker and analyzed the influence of viral etiology on AFP levels in HCC...
  53. ncbi Expression and location of alpha-fetoprotein during rat colon development
    Xiao Yan Liu
    Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu Province, China
    World J Gastroenterol 15:1738-43. 2009
    ..To investigate the expression of alpha-fetoprotein (AFP), a cancer-associated fetal glycoprotein, and its involvement during rat colon development...
  54. ncbi [Correlation of perioperative alpha-fetoprotein expression in peripheral blood to recurrence of hepatocellular carcinoma]
    Ming Shi
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, PR China
    Ai Zheng 27:83-7. 2008
    ..This study was to explore the correlation of perioperative AFP expression in peripheral blood to recurrence of HCC...
  55. ncbi Hepatocellular carcinoma (HCC) and diagnostic significance of A-fetoprotein (AFP)
    Jawed Altaf Baig
    Department of Biochemistry, Liaquat National Medical College, Karachi, Pakistan
    J Ayub Med Coll Abbottabad 21:72-5. 2009
    ....
  56. ncbi Clinical utility of highly sensitive Lens culinaris agglutinin-reactive alpha-fetoprotein in hepatocellular carcinoma patients with alpha-fetoprotein <20 ng/mL
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Cancer Sci 102:1025-31. 2011
    ..001). In patients with AFP <20 ng/mL, measurements of AFP-L3% by the highly sensitive method before treatment were more useful for diagnosis and prognosis of HCC than by the conventional method...
  57. ncbi Regulation of the alpha-fetoprotein gene by the isoforms of ATBF1 transcription factor in human hepatoma
    Toshiaki Ninomiya
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    Hepatology 35:82-7. 2002
    ..Thus, the use of the ATBF1 variants as well as the silencer may provide a unique mechanism that contributes to the determination of AFP levels in human hepatoma cell lines...
  58. ncbi Clinical significance of elevated alpha-fetoprotein in Alaskan Native patients with chronic hepatitis C
    M G Bruce
    National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AL 99508, USA
    J Viral Hepat 15:179-87. 2008
    ..Serial AFP measurements appear to be useful in identifying persons with advanced fibrosis and help to determine who needs periodic screening with liver ultrasound to detect HCC...
  59. ncbi alpha-fetoprotein causes apoptosis in tumor cells via a pathway independent of CD95, TNFR1 and TNFR2 through activation of caspase-3-like proteases
    E Dudich
    Institute of Engineering Immunology, Lyubuchany, Moscow Region, Russia
    Eur J Biochem 266:750-61. 1999
    ....
  60. ncbi Simultaneous determination of alpha-fetoprotein immune complexes and alpha-fetoprotein concentration in hepatocellular carcinoma using dual-label time-resolved immunofluorometric assays
    Shi Le Sheng
    Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University Medical School, Shanghai, China
    J Clin Lab Anal 23:179-85. 2009
    ..The combined use of AFP-IgM and AFP increased the sensitivity of detection to 72.88% in patients with HCC. These data suggest that the use of a combination of two markers in clinical practice could increase the accuracy of HCC diagnosis...
  61. ncbi Alpha-fetoprotein in plasma and serum of healthy adults: preanalytical, analytical and biological sources of variation and construction of age-dependent reference intervals
    M Christiansen
    Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
    Scand J Clin Lab Invest 61:205-15. 2001
    ..With broad population reference ranges and slight intra-personal variation, the most effective reference range for S-AFP is previous values obtained in the same person...
  62. ncbi Specific uptake of alpha-fetoprotein and albumin by rat Morris 7777 hepatoma cells
    M A Alava
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain
    Tumour Biol 20:52-64. 1999
    ....
  63. ncbi Risk of vaccine-associated paralytic poliomyelitis in Latin America, 1989-91
    J K Andrus
    Expanded Programme on Immunization, WHO Regional Office for South East Asia, New Delhi, India
    Bull World Health Organ 73:33-40. 1995
    ..These data suggest that to eradicate poliomyelitis globally, strategies that rely on mass immunization campaigns to supplement routine delivery services, as recommended by WHO, do not appear to alter significantly the risk of VAPP...
  64. ncbi Epidemiology and clinical characteristics of acute flaccid paralysis associated with non-polio enterovirus isolation: the experience in the Americas
    V Dietz
    National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Bull World Health Organ 73:597-603. 1995
    ..It is therefore questionable whether characterization of NPEV isolates is essential for global eradication of poliomyelitis and consequently whether allocation of resources for that purpose can be justified...
  65. ncbi Poliomyelitis in Oman: acute flaccid paralysis surveillance leading to early detection and rapid response to a type 3 outbreak
    S E Robertson
    Global Programme for Vaccines and Immunization, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 72:907-14. 1994
    ..Because AFP surveillance detected these cases rapidly, Oman was able to carry out outbreak control measures promptly and more than 350,000 extra doses of oral poliovirus vaccine were delivered to children under 6 years of age...
  66. ncbi Screening of cases of acute flaccid paralysis for poliomyelitis eradication: ways to improve specificity
    J K Andrus
    EPI PAHO, Expanded Programme on Immunization, Pan American Health Organization, Washington, DC 20037
    Bull World Health Organ 70:591-6. 1992
    ....
  67. ncbi Poliomyelitis surveillance in Shandong Province, China, 1990-92
    Y Chiba
    Department of EPI, Shandong Provincial Epidemic Prevention Station, Jinan, China
    Bull World Health Organ 72:915-20. 1994
    ..As the prevalence of wild poliovirus declines in China, reliable laboratory support needs to be established and adequately sensitive and specific AFP surveillance be developed if poliomyelitis is to be eradicated...
  68. ncbi Primary intracranial germ-cell tumors. A retrospective analysis with special reference to long-term results of treatment and the behavior of rare types of tumors
    N Sakai
    Department of Neurosurgery, Gifu University, School of Medicine, Japan
    Acta Oncol 27:43-50. 1988
    ..A review of the literature is included...
  69. ncbi [Ultrasonically guided radio-frequency ablation of liver tumors with a clustered electrode: a report of 100 cases]
    Q Ma
    Department of General Surgery, Tangdu Hospital, Forth Military Medical University, Xi'an 710038, China
    Zhonghua Wai Ke Za Zhi 38:272-4, 18. 2000
    ..AFP value decreased in 50% of patients, no operative death was noted, and the rate of operative complication was 23% after ablation. CONCLUSION: Ultrasound guided RF thermal ablation of hepatic tumors is safe, applicable and effective...
  70. ncbi Cisplatinum dose dependent response in germ cell cancer evaluated by tumour marker modelling
    J Carl
    Department of Experimental Clinical Oncology, Danish Cancer Society, Aalborg
    Acta Oncol 31:749-53. 1992
    ..Treatment response versus DDP dose appeared to be bi-phasic, but with no significant change in treatment efficiency within the given range of DDP doses...
  71. ncbi Early on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma
    Myoung Ha Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 27:313-22. 2012
    ....
  72. ncbi Covert skill learning in a cortical-basal ganglia circuit
    Jonathan D Charlesworth
    W M Keck Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, California 94143, USA
    Nature 486:251-5. 2012
    ....
  73. ncbi Glycomic analysis of alpha-fetoprotein L3 in hepatoma cell lines and hepatocellular carcinoma patients
    Takatoshi Nakagawa
    Department of Glycotherapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Osaka 565 0871, Japan
    J Proteome Res 7:2222-33. 2008
    ..Moreover, we identified the N-glycan structures of AFP in HCC patients...
  74. ncbi Ultrasound detection of placental insufficiency in women with elevated second trimester serum alpha-fetoprotein or human chorionic gonadotropin
    Meghana Toal
    Department of Obstetrics and Gynaecology Maternal Fetal Medicine Division Placenta Clinic, Mount Sinai Hospital, University of Toronto, Toronto ON
    J Obstet Gynaecol Can 30:198-206. 2008
    ....
  75. ncbi The prognostic value of tumor markers in newly diagnosed patients with primary central nervous system germ cell tumors
    Aerang Kim
    New York University Medical Center, New York, New York, USA
    Pediatr Blood Cancer 51:768-73. 2008
    ....
  76. ncbi Improved viability and reduced apoptosis in sub-zero 21-hour preservation of transplanted rat hearts using anti-freeze proteins
    Gabriel Amir
    Heart Transplantation Unit, Department of Cardiac Surgery, Sheba Medical Center, Tel Hashomer, Israel
    J Heart Lung Transplant 24:1915-29. 2005
    ..We sought to evaluate and compare the effects of prolonged sub-zero cryopreservation of transplanted rat hearts using AFP I or AFP III...
  77. ncbi Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma
    Noboru Mitsuhashi
    Section for Medical Nanotechniques, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e189-97. 2008
    ..However, there have been few reports on the reasons for poor prognosis...
  78. ncbi Immunotherapy of hepatocellular carcinoma with a vaccine based on xenogeneic homologous alpha fetoprotein in mice
    Wei Zhang
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Gao Xin Qu Ke Yuan 4th Road No 1, Chengdu, Sichuan, People s Republic of China
    Biochem Biophys Res Commun 376:10-4. 2008
    ..Thus, our study may provide an effective vaccine strategy for the treatment of AFP-positive hepatocellular carcinoma, and may be of importance to further exploration of the breaking of immune tolerance to self molecules...
  79. ncbi Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver
    Zhifang Xie
    Department of Pathophysiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Proc Natl Acad Sci U S A 105:10859-64. 2008
    ..Our data point to ZBTB20 as a key regulator governing AFP gene transcription and postulate a new model for the postnatal gene repression of AFP in liver...
  80. ncbi Clinical evaluation of lens culinaris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States
    Brian I Carr
    Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, E1552 BST, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 52:776-82. 2007
    ..AFP-L3% was significantly related to portal vein invasion and patient outcomes and appears to be a useful prognostic marker for HCC...
  81. ncbi Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma
    Yulin Sun
    State Key Laboratory of Molecular Oncology, Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 P R China
    J Proteome Res 7:3847-59. 2008
    ..These novel findings may provide important clues to identify new biomarkers of HCC and indirectly improve early detection of the disease...
  82. ncbi Comparison between human-telomerase reverse transcriptase mRNA and alpha-fetoprotein mRNA as a predictive value for recurrence of hepatocellular carcinoma in living donor liver transplantation
    H Oya
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Transplant Proc 38:3636-9. 2006
    ....
  83. ncbi Significance of hepatitis B virus surface antigen, hepatitis C virus expression in hepatocellular carcinoma and pericarcinomatous tissues
    Shi Ying Xuan
    College of Medicine and Pharmaceutics, Ocean University of China, 5 Yushan Road, Qingdao 266003, Shandong Province, China
    World J Gastroenterol 13:1870-4. 2007
    ..the correlation between hepatitis B virus surface antigen (HBsAg), hepatitis C virus (HCV) expression in hepatocellular carcinoma (HCC), the HAI score of the noncancerous region of the liver and the serum Alpha fetoprotein (AFP) level.
  84. ncbi [Hepatocyte growth factor and fibroblast growth factor-4-induced differentiation of human bone marrow mesenchymal stem cells into hepatocyte-like cells in vitro]
    Jin min Xie
    Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1439-42. 2006
    ..To induce the differentiation of human bone marrow mesenchymal stem cells (HMSCs) into hepatocyte-like cells with hepatocyte growth factor (HGF) and fibroblast growth factor-4 (FGF-4) in vitro...
  85. ncbi The predictive ability of serum alpha-fetoprotein for hepatocellular carcinoma is linked with the characteristics of the target population at surveillance
    Teh Ia Huo
    Institute of Pharmacology, National Yang Ming University School of Medicine, Taipei, Taiwan
    J Surg Oncol 95:645-51. 2007
    ..The reported predictive accuracy of AFP for HCC widely varied. This study investigated the factors contributory to the heterogeneity of the ability of AFP to detect HCC...
  86. ncbi Alpha fetoprotein is increasing with age in ataxia-telangiectasia
    A Stray-Pedersen
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Norway
    Eur J Paediatr Neurol 11:375-80. 2007
    The elevated serum alpha fetoprotein (AFP) concentration in ataxia-telangiectasia (A-T) patients has been known for decades, but the individual variation of AFP levels over time has not been studied...
  87. ncbi Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis
    J Thompson Coon
    Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Exeter, UK
    Health Technol Assess 11:1-206. 2007
    ....
  88. ncbi Effect of freeze-thaw cycles on serum measurements of AFP, CEA, CA125 and CA19-9
    Y C Gao
    The Immunoassay Laboratory, Department of Nuclear Medicine, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Scand J Clin Lab Invest 67:741-7. 2007
    ..So it seems that measurements of AFP, CEA and CA125 are more readily affected by long-term frozen storage compared with frequent freezing-thawing, while CA19-9 is relatively unstable under both conditions...
  89. ncbi Single nucleotide polymorphism in the promoter region of human alpha-fetoprotein (AFP) gene and its significance in hepatocellular carcinoma (HCC)
    G G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Eur J Surg Oncol 33:882-6. 2007
    ..To understand the potential mechanism underlying the differential expression of AFP, we have examined the sequence of the AFP promoter in HCC...
  90. ncbi ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines
    H Shen
    Institute of Immunology, School of Medicine, Shandong University, Wenhua Xi Road, Jinan, PR China
    J Cell Mol Med 12:2772-80. 2008
    ..These data support the idea that ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer...
  91. ncbi Growth inhibition mechanism of an ice-water interface by a mutant of winter flounder antifreeze protein: a molecular dynamics study
    Hiroki Nada
    National Institute of Advanced Industrial Science and Technology AIST, 16 1 Onogawa, Tsukuba, Japan
    J Phys Chem B 112:7111-9. 2008
    ..These results agree with the fact that AFPs inhibit the growth of ice only on the pyramidal planes in real systems...
  92. ncbi Molecular background of alpha-fetoprotein in liver cancer cells as revealed by global RNA expression analysis
    Shigeru Saito
    Proteome Bioinformatics Project, National Cancer Center Research Institute, Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Sci 99:2402-9. 2008
    ..From this genome-wide association study, novel aspects of the molecular background of AFP were revealed, and thus may lead to the identification of novel biomarker candidates...
  93. ncbi Human alpha-fetoprotein peptides bind estrogen receptor and estradiol, and suppress breast cancer
    D Vakharia
    Division of Environmental Disease Prevention and Molecular Medicine, Wadsworth Center, NYS Department of Health, Albany, NY, USA
    Breast Cancer Res Treat 63:41-52. 2000
    ..The recent epidemiologic observation that high AFP levels in young pregnant women reduce their subsequent risk of postmenopausal breast cancer may be related to the growth suppressive property of AFP with the exposed P149 epitope...
  94. ncbi To plug or not to plug: a cost-effectiveness analysis for complex anal fistula
    Michel Adamina
    Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Surgery 147:72-8. 2010
    ..This study aims to evaluate the cost-effectiveness of the AFP compared to the endoanal advancement flap (EAAF) as an alternative sphincter-preserving option for complex anal fistulas...
  95. ncbi Lectin-dependent modulation of interaction between human alpha-fetoprotein and its monoclonal antibodies. Epitope mapping
    K Taketa
    Department of Public Health, Okayama University Medical School, Japan
    Tumour Biol 19:318-28. 1998
    ..The enhanced binding of some MoAbs to AFP-L3 over AFP-L1 with LCA, or both glycoforms of AFP with concanavalin A, may be explained by postulating an allosteric mechanism mediated by the oligosaccharide-lectin interaction...
  96. ncbi Surveillance of acute flaccid paralysis in The Netherlands, 1992-94
    P M Oostvogel
    Research Laboratory for Infectious Diseases, WHO Collaborating Centre for Reference and Research on Poliomyelitis, Rijks Instituut voor Volksgezondheid en Milieu RIVM, Bilthoven, Netherlands
    Bull World Health Organ 76:55-62. 1998
    ..For certification purposes, the present AFP surveillance system in the Netherlands needs to be improved with respect to coverage by including neurologists, rapidity of reporting, and completeness of laboratory investigations...
  97. ncbi Retinoic acid differentially regulates retinoic acid receptor-mediated pathways in the Hep3B cell line
    Y J Wan
    Department of Pathology, Harbor UCLA Medical Center, Torrance 90509, USA
    Exp Cell Res 238:241-7. 1998
    ..In addition, the RA-mediated reduction of RXR alpha in part results in down-regulation of the AFP gene. Our data indicates that RA exerts its effects by differentially regulating its own receptor gene expression...
  98. ncbi Expression of serum albumin and of alphafetoprotein in murine normal and neoplastic primitive embryonic structures
    J Trojan
    IRSC CNRS, Hopital Paul Brosse, Villejuif, France
    Mol Reprod Dev 42:369-78. 1995
    ..The same SA:AFP relationship constitutes an oncofetal marker of primitive neuroectoblastic structures...
  99. ncbi Copper(II)-binding ability of human alpha-fetoprotein
    Y Aoyagi
    Cancer Res 38:3483-6. 1978
    ..These results indicate that the histidyl residue at the amino-terminal region of alpha-fetoprotein plays an important role in the copper(II)-binding ability of the protein...
  100. ncbi [Expression and localization of strong epitope hAFP(542-550); on eukaryotic cytoplasmic membrane]
    Dong Ye Yang
    Department of Digestive Diseases at Xiangya Second Hospital, Central South University, Changsha 410011, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25:592-5, 599. 2009
    ..To construct the recombinant plasmid of pGPC3-EGFP containing human AFP(542-550) gene, EGFP gene and GPC3 gene to express fusion protein GPC3-hAFP(542-550)-EGFP and to discover its localization on cytoplasmic membrane...
  101. ncbi An evaluation of the sensitivity of acute flaccid paralysis surveillance for poliovirus infection in Australia
    Rochelle E Watkins
    Australian Biosecurity CRC for Emerging Infectious Disease, Faculty of Health Sciences, Curtin University of Technology, Perth, Australia
    BMC Infect Dis 9:162. 2009
    ..We applied recently developed methods for the quantitative evaluation of disease surveillance systems to evaluate the sensitivity of AFP surveillance for poliovirus infection in Australia...

Research Grants69

  1. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
    ..In previous work we have shown that both the murine and human T cell repertoires can recognize alpha fetoprotein (AFP)-derived peptide epitopes in the context of MHC...
  2. CHARACTERIZATION OF VITAMIN D BINDING PROTEIN GENES
    Nancy Cooke; Fiscal Year: 1993
    ..These studies are intended to clarify current understanding of DBP gene expression, function, and structure in the context of the most abundantly expressed serum protein gene family...
  3. Pregnancy Hormonal Profile/Biomarker Breast Cancer Risk
    Alan Arslan; Fiscal Year: 2004
    ..Moreover, specific hormone(s) or its analogues responsible for protective effect of pregnancy against breast cancer could be used for development of novel strategies for primary chemoprevention of breast cancer. ..
  4. In Vitro Reconstitution of Alpha Fetroprotein Regulation
    Michelle Barton; Fiscal Year: 2007
    ..To test this hypothesis, we will assemble AFP gene templates into developmentally repressed, solid-phase nuclei and analyze chromatin structure and transcription function before and after DNA replication. ..
  5. RETINOIC ACID RECEPTOR, ALPHA-FETOPROTEIN, AND HEPATOMA
    YU JUI WAN; Fiscal Year: 2003
    ..The results obtained from this proposal will enhance our understanding in the actions of RA on hepatocyte differentiation and antiproliferation. ..
  6. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2007
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against ¿-catenin in HCC. ..
  7. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN SINGH MONGA; Fiscal Year: 2010
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against -catenin in HCC. ..
  8. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2009
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against -catenin in HCC. ..
  9. IN VITRO RECONSTITUTION OF ALPHA FETOPROTEIN REGULATION
    Michelle Barton; Fiscal Year: 2003
    ..In pursuing this goal, we will develop an in vitro model of tumorigenic activation of the mouse AFP gene that reconstitutes many properties of the nuclear environment and regulation while remaining biochemically accessible. ..
  10. Genetic Immunotherapy for Hepatocellular Cancer
    James Economou; Fiscal Year: 2004
    ..Both the murine and human T cell repertoires can recognize alpha fetoprotein (AFP), an oncofetal protein produced by a majority of HCC...
  11. Phase-Changing Sacrificial Layer Microfluidics for Enhanced Protein Analysis
    ADAM THOMAS WOOLLEY; Fiscal Year: 2010
    ..Thus, PCSL techniques and polymer surface derivatization methods should provide a broadly applicable microchip platform for the electrophoretic analysis and quantification of proteins or other biomolecules in humans. ..
  12. Phase-Changing Sacrificial Layer Microfluidics for Enhanced Protein Analysis
    ADAM WOOLLEY; Fiscal Year: 2007
    ..Thus, PCSL techniques and polymer surface derivatization methods should provide a broadly applicable microchip platform for the electrophoretic analysis and quantification of proteins or other biomolecules in humans. ..
  13. Phase-Changing Sacrificial Layer Microfluidics for Enhanced Protein Analysis
    ADAM WOOLLEY; Fiscal Year: 2009
    ..Thus, PCSL techniques and polymer surface derivatization methods should provide a broadly applicable microchip platform for the electrophoretic analysis and quantification of proteins or other biomolecules in humans. ..
  14. LONG DISTANCE CONTROL OF LIVER GENE EXPRESSION
    Joseph Locker; Fiscal Year: 2000
    ..Plasmids will be generated to establish a second model system for the study of long-distance gene regulation within a chromosomal locus with properties very different from the beta globin locus. ..
  15. AFP-BASED PRIME-BOOST IMMUNOTHERAPY OF HCC
    LISA BUTTERFIELD; Fiscal Year: 2006
    ..Previously, we made the novel observation that alpha fetoprotein (AFP) can be recognized by human and murine immune systems...