Gene Symbol: alpha-actinin
Description: actinin alpha 1
Alias: BDPLT15, alpha-actinin-1, F-actin cross-linking protein, actinin 1 smooth muscle, alpha-actinin cytoskeletal isoform, non-muscle alpha-actinin-1
Species: human
Products:     alpha-actinin

Top Publications

  1. Millake D, Blanchard A, Patel B, Critchley D. The cDNA sequence of a human placental alpha-actinin. Nucleic Acids Res. 1989;17:6725 pubmed
  2. Otey C, Pavalko F, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. J Cell Biol. 1990;111:721-9 pubmed
    ..These results lead us to suggest that this integrin-alpha-actinin linkage may contribute to the attachment of actin filaments to the membrane in certain locations. ..
  3. Reinhard M, Zumbrunn J, Jaquemar D, Kuhn M, Walter U, Trueb B. An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment. J Biol Chem. 1999;274:13410-8 pubmed
    ..Our results suggest a crucial role for the alpha-actinin-zyxin interaction in subcellular zyxin localization and microfilament organization. ..
  4. Gonzalez A, Otey C, Edlund M, Jones J. Interactions of a hemidesmosome component and actinin family members. J Cell Sci. 2001;114:4197-206 pubmed
    ..We discuss a role for BP180 in crosstalk between cell-matrix and cell-cell junctions. ..
  5. Gluck U, Ben Ze ev A. Modulation of alpha-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells. J Cell Sci. 1994;107 ( Pt 7):1773-82 pubmed
  6. Luikart S, Wahl D, Hinkel T, Masri M, Oegema T. A fragment of alpha-actinin promotes monocyte/macrophage maturation in vitro. Exp Hematol. 1999;27:337-44 pubmed
    ..This represents the first example of a fragment of a cytoskeletal component, which may be released during tissue remodeling and repair, playing a role in phagocyte maturation. ..
  7. Vallenius T, Luukko K, Mäkelä T. CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4. J Biol Chem. 2000;275:11100-5 pubmed
    ..More generally, results presented here demonstrate that the association of PDZ-LIM proteins with the cytoskeleton extends to the actin stress fibers of nonmuscle cells. ..
  8. Kelly D, Taylor D, Bakolitsa C, Bobkov A, Bankston L, Liddington R, et al. Structure of the alpha-actinin-vinculin head domain complex determined by cryo-electron microscopy. J Mol Biol. 2006;357:562-73 pubmed
    ..The results show that the interaction between two species with weak affinity can be visualized in a membrane-like environment. ..
  9. Quick Q, Skalli O. Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells. Exp Cell Res. 2010;316:1137-47 pubmed publisher

More Information

Publications150 found, 100 shown here

  1. Kunishima S, Okuno Y, Yoshida K, Shiraishi Y, Sanada M, Muramatsu H, et al. ACTN1 mutations cause congenital macrothrombocytopenia. Am J Hum Genet. 2013;92:431-8 pubmed publisher
    ..Our findings provide an insight into the pathogenesis of CMTP...
  2. Edlund M, Lotano M, Otey C. Dynamics of alpha-actinin in focal adhesions and stress fibers visualized with alpha-actinin-green fluorescent protein. Cell Motil Cytoskeleton. 2001;48:190-200 pubmed
    ..Additionally, the exchange rates revealed by video-microscopy and FRAP analysis of alpha AGFP are more rapid than those reported previously, which were obtained using microinjection of large excesses of fluorescently-tagged protein. ..
  3. Gizak A, Rakus D, Dzugaj A. Immunohistochemical localization of human fructose-1,6-bisphosphatase in subcellular structures of myocytes. Histol Histopathol. 2003;18:135-42 pubmed publisher
    ..This is the first report on localization of FBPase in skeletal muscle tissue. ..
  4. Elkins J, Gileadi C, Shrestha L, Phillips C, Wang J, Muniz J, et al. Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms. Protein Sci. 2010;19:731-41 pubmed publisher
    ..Comparison with canonical binding suggests that the rearrangement during binding involves both the PDZ domain and its ligand. ..
  5. Rönty M, Taivainen A, Moza M, Otey C, Carpen O. Molecular analysis of the interaction between palladin and alpha-actinin. FEBS Lett. 2004;566:30-4 pubmed
    ..Using transfection-based targeting assays, we show that palladin is involved in targeting of alpha-actinin to specific subcellular foci indicating a functional interplay between the two actin-associated proteins. ..
  6. Windhorst S, Kalinina T, Schmid K, Blechner C, Kriebitzsch N, Hinsch R, et al. Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells. Int J Cancer. 2011;129:1300-9 pubmed publisher
    ..Therefore, we suggest that ITPKA may be a promising therapeutic molecular target for anti metastatic therapy of lung cancer. ..
  7. Yang L, Yu P, Chen X, Cai T. The de novo missense mutation N117S in skeletal muscle ??actin 1 causes a mild form of congenital nemaline myopathy. Mol Med Rep. 2016;14:1693-6 pubmed publisher
    ..In conclusion, this approach may be helpful for the identification of clinically undiagnosed patients with highly heterogeneous disorders. ..
  8. Gunasekharan V, Li Y, Andrade J, Laimins L. Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle. PLoS Pathog. 2016;12:e1005747 pubmed publisher
    ..KLF4 has also been shown to be a critical regulator of lytic Epstein Barr virus (EBV) replication underscoring the importance of this cellular transcription factor in the life cycles of multiple human cancer viruses. ..
  9. Li B, Trueb B. Analysis of the alpha-actinin/zyxin interaction. J Biol Chem. 2001;276:33328-35 pubmed
    ..This binding site involved a tandem array of two complete spectrin-like domains. Only fragments that were able to dimerize in yeast also bound to zyxin, suggesting that dimerization of alpha-actinin is essential for zyxin binding. ..
  10. Li B, Zhuang L, Reinhard M, Trueb B. The lipoma preferred partner LPP interacts with alpha-actinin. J Cell Sci. 2003;116:1359-66 pubmed
    ..It is likely that this difference leads to slightly different roles played by LPP and zyxin during the assembly and disassembly of focal adhesions. ..
  11. Klinck R, Fourrier A, Thibault P, Toutant J, Durand M, Lapointe E, et al. RBFOX1 cooperates with MBNL1 to control splicing in muscle, including events altered in myotonic dystrophy type 1. PLoS ONE. 2014;9:e107324 pubmed publisher
    ..Our results suggest that reduced RBFOX1 activity in DM1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1. ..
  12. Schick U, Jain D, Hodonsky C, Morrison J, Davis J, Brown L, et al. Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans. Am J Hum Genet. 2016;98:229-42 pubmed publisher
    ..Our results underscore the value of diverse populations to extend insights into the allelic architecture of complex traits. ..
  13. Sun Y, Hu W, Yu X, Liu Z, Tarran R, Ravid K, et al. Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression. Biochem J. 2016;473:2179-86 pubmed publisher
    ..By contrast, actinin-4, another non-muscle actinin isoform, did not bind to A2BAR. Thus our findings reveal a previously unidentified regulatory mechanism of A2BAR abundance. ..
  14. Full S, Deinzer M, Ho P, Greenwood J. Phosphoinositide binding regulates alpha-actinin CH2 domain structure: analysis by hydrogen/deuterium exchange mass spectrometry. Protein Sci. 2007;16:2597-604 pubmed
  15. Bestman J, Huang L, Lee Osbourne J, Cheung P, Cline H. An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system. Dev Biol. 2015;408:269-91 pubmed publisher
  16. Menko S, Philp N, Veneziale B, Walker J. Integrins and development: how might these receptors regulate differentiation of the lens. Ann N Y Acad Sci. 1998;842:36-41 pubmed
    ..The role of integrins in lens development is not only regulated by changes in the expression of different integrin receptors but is also closely correlated with the expression and organization of the molecules with which they associate. ..
  17. Slater M, Cooper M, Murphy C. The cytoskeletal proteins alpha-actinin, Ezrin, and talin are De-expressed in endometriosis and endometrioid carcinoma compared with normal uterine epithelium. Appl Immunohistochem Mol Morphol. 2007;15:170-4 pubmed
    ..It also indicates a similarity between endometrioid cancer and endometriosis with respect to epithelial cell function and adhesion...
  18. Khurana S, Chakraborty S, Lam M, Liu Y, Su Y, Zhao X, et al. Familial focal segmental glomerulosclerosis (FSGS)-linked ?-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors. J Biol Chem. 2012;287:12027-35 pubmed publisher
    ..Our data provide the first link between FSGS-linked ACTN4 mutants and transcriptional activation by nuclear receptor such as RAR? and peroxisome proliferator-activated receptor ?. ..
  19. Tokuue Y, Goto S, Imamura M, Obinata T, Masaki T, Endo T. Transfection of chicken skeletal muscle alpha-actinin cDNA into nonmuscle and myogenic cells: dimerization is not essential for alpha-actinin to bind to microfilaments. Exp Cell Res. 1991;197:158-67 pubmed
    ..Thus, dimer formation is not essential for alpha-actinin molecules to bind to microfilaments. ..
  20. Knudsen K, Soler A, Johnson K, Wheelock M. Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. J Cell Biol. 1995;130:67-77 pubmed
    ..We therefore propose that cadherin/catenin complexes are linked to the actin cytoskeleton via a direct association between alpha-actinin and alpha-catenin. ..
  21. Foley K, Young P. An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle ?-actinins. Biochem J. 2013;452:477-88 pubmed publisher
    ..This significantly alters our view of non-muscle actinin function. ..
  22. Myers J, Vallega K, White J, Yu K, Yates C, Sang Q. Proteomic characterization of paired non-malignant and malignant African-American prostate epithelial cell lines distinguishes them by structural proteins. BMC Cancer. 2017;17:480 pubmed publisher
    ..Although the RC-77 cell model may not be representative of all African-American prostate cancer due to tumor heterogeneity, it is a unique resource for studying prostate cancer initiation and progression. ..
  23. Nishiyama M, Ozturk M, Frohlich M, Mafune K, Steele G, Wands J. Expression of human alpha-actinin in human hepatocellular carcinoma. Cancer Res. 1990;50:6291-4 pubmed
    ..We conclude that the alpha-actinin gene is highly expressed when hepatocytes have assumed the malignant phenotype. ..
  24. Salmikangas P, van der Ven P, Lalowski M, Taivainen A, Zhao F, Suila H, et al. Myotilin, the limb-girdle muscular dystrophy 1A (LGMD1A) protein, cross-links actin filaments and controls sarcomere assembly. Hum Mol Genet. 2003;12:189-203 pubmed
    ..The disease association and functional characteristics indicate an indispensable role for myotilin in stabilization and anchorage of thin filaments, which may be a prerequisite for correct Z-disc organization. ..
  25. Bois P, Borgon R, Vonrhein C, Izard T. Structural dynamics of alpha-actinin-vinculin interactions. Mol Cell Biol. 2005;25:6112-22 pubmed
    ..The data suggest a model where vinculin's Vh1 domain acts as a molecular switch that undergoes distinct structural changes provoked by talin and alpha-actinin binding in focal adhesions versus adherens junctions, respectively. ..
  26. Triplett J, Pavalko F. Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis. Am J Physiol Cell Physiol. 2006;291:C909-21 pubmed
    ..Thus we conclude that alpha-actinin plays a role in regulating cell survival through stabilization of focal adhesions and regulation of TNF-alpha-induced survival signaling. ..
  27. Nyman Huttunen H, Tian L, Ning L, Gahmberg C. alpha-Actinin-dependent cytoskeletal anchorage is important for ICAM-5-mediated neuritic outgrowth. J Cell Sci. 2006;119:3057-66 pubmed
  28. Li Y, Wang J, Zhou Y, Li D, Xiong Z. Rcan1 deficiency impairs neuronal migration and causes periventricular heterotopia. J Neurosci. 2015;35:610-20 pubmed publisher
    ..Together, these findings demonstrate that Rcan1 acts upstream from Flna in regulating radial migration and suggest that impairment of Rcan1-Flna pathway may underlie PH pathogenesis. ..
  29. Sartaj R, Zhang C, Wan P, Pasha Z, Guaiquil V, Liu A, et al. Characterization of slow cycling corneal limbal epithelial cells identifies putative stem cell markers. Sci Rep. 2017;7:3793 pubmed publisher
    ..Overlapping retention of GFP and immunohistochemical expression of Krt15, ΔNp63, Sox9, Actn1, Fzd7 and Krt17 were observed in our transgenic model. Our analysis presents an array of novel genes as putative corneal stem cell markers. ..
  30. Caporaso N, Gu F, Chatterjee N, Sheng Chih J, Yu K, Yeager M, et al. Genome-wide and candidate gene association study of cigarette smoking behaviors. PLoS ONE. 2009;4:e4653 pubmed publisher
    ..4x10(-5)), our analysis provides independent replication of the association between the chr15q25.1 region and smoking intensity and data for multiple other loci associated with smoking behavior that merit further follow-up. ..
  31. Ziane R, Huang H, Moghadaszadeh B, Beggs A, Levesque G, Chahine M. Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction. Biochemistry. 2010;49:166-78 pubmed publisher
    ..Our data suggest that alpha-actinin-2, which is known to regulate the functional expression of the potassium channels, may play a role in anchoring Na(v)1.5 to the membrane by connecting the channel to the actin cytoskeleton network. ..
  32. Shao H, Li S, Watkins S, Wells A. α-Actinin-4 is required for amoeboid-type invasiveness of melanoma cells. J Biol Chem. 2014;289:32717-28 pubmed publisher
    ..Taken together, these findings suggest that ACTN4 plays an important role in maintaining the amoeboidal morphology of invasive melanoma and thus promoting dissemination through collagen-rich matrices. ..
  33. Yuan Y, Zhang F, Wu J, Shao C, Gao Y. Urinary candidate biomarker discovery in a rat unilateral ureteral obstruction model. Sci Rep. 2015;5:9314 pubmed publisher
  34. Schmidt S, Linge A, Zwanenburg A, Leger S, Lohaus F, Krenn C, et al. Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy. Clin Cancer Res. 2018;24:1364-1374 pubmed publisher
    ..A prospective validation is planned in an ongoing prospective clinical trial before potential application in clinical trials for patient stratification. Clin Cancer Res; 24(6); 1364-74. ©2018 AACR. ..
  35. Usik M, Ogneva I. Cytoskeleton Structure in Mouse Sperm and Testes After 30 Days of Hindlimb Unloading and 12 Hours of Recovery. Cell Physiol Biochem. 2018;51:375-392 pubmed publisher
    ..Moreover, the decrease was prevented by the administration of essential phospholipids. ..
  36. Dubernard V, Faucher D, Launay J, Legrand C. Identification of the cytoskeletal protein alpha-actinin as a platelet thrombospondin-binding protein. FEBS Lett. 1995;364:109-14 pubmed
    ..We further demonstrated that [125I]TSP interacts with alpha-actinin in a specific manner and with a high affinity (Kd = 6.6 nM) in a solid-phase binding assay. ..
  37. Nakagawa N, Hoshijima M, Oyasu M, Saito N, Tanizawa K, Kuroda S. ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain. Biochem Biophys Res Commun. 2000;272:505-12 pubmed
  38. Rönty M, Taivainen A, Moza M, Kruh G, Ehler E, Carpen O. Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton. Exp Cell Res. 2005;310:88-98 pubmed
    ..The interactions provide an explanation to the previously observed Z-disc-specific localization of ArgBP2 and indicate interplay between signaling adaptors and structural proteins of the Z-disc. ..
  39. Hall D, Dai S, Tseng P, Malik Z, Nguyen M, Matt L, et al. Competition between ?-actinin and Ca²?-calmodulin controls surface retention of the L-type Ca²? channel Ca(V)1.2. Neuron. 2013;78:483-97 pubmed publisher
    ..2 at the plasma membrane and that its displacement by Ca²?-calmodulin triggers Ca²?-induced endocytosis of Ca(V)1.2, thus providing an important negative feedback mechanism for Ca²? influx. ..
  40. Panichakul T, Ponnikorn S, Roytrakul S, Paemanee A, Kittisenachai S, Hongeng S, et al. Plasmodium vivax inhibits erythroid cell growth through altered phosphorylation of the cytoskeletal protein ezrin. Malar J. 2015;14:138 pubmed publisher
    ..Interestingly, the levels of three phosphoproteins: ezrin, alpha actinin-1, and Rho kinase were significantly (p < 0.05) altered...
  41. Pollock L, Gupta N, Chen X, Luna E, McDermott B. Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. PLoS ONE. 2016;11:e0158349 pubmed publisher
    ..Overall, supervillin localization suggests this protein may shape the surface structure of the organ of Corti. ..
  42. Salmikangas P, Mykkänen O, Grönholm M, Heiska L, Kere J, Carpen O. Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy. Hum Mol Genet. 1999;8:1329-36 pubmed
    ..The muscle specificity and apparent role as a sarcomeric structural protein raise the possibility that defects in the myotilin gene may cause muscular dystrophy. ..
  43. Harper B, Beckerle M, Pomies P. Fine mapping of the alpha-actinin binding site within cysteine-rich protein. Biochem J. 2000;350 Pt 1:269-74 pubmed
    ..The critical lysine residue localizes within a short alpha-helix, raising the possibility that mutagenesis-induced alterations in alpha-actinin-binding capacity might be attributed to the disruption of a key structural element. ..
  44. Garvalov B, Higgins T, Sutherland J, Zettl M, Scaplehorn N, Kocher T, et al. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol. 2003;161:33-9 pubmed
    ..However, using RNAi ablation, we demonstrate that zyxin is required to recruit Tes, as well as Mena and VASP, but not vinculin or paxillin, to focal adhesions. ..
  45. Sen S, Dong M, Kumar S. Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology. PLoS ONE. 2009;4:e8427 pubmed publisher
  46. Wu Z, Wang S, Jiang F, Li Q, Wang C, Wang H, et al. Mass spectrometric detection combined with bioinformatic analysis identified possible protein markers and key pathways associated with bladder cancer. Gene. 2017;626:407-413 pubmed publisher
    ..The ECM-receptor interaction pathway and the focal adhesion pathway may be involved in the progression of bladder cancer. Furthermore, ACTN1 and VCL may play roles in bladder cancer development, partly via the focal adhesion pathway. ..
  47. Sverdlov M, Shinin V, Place A, Castellon M, Minshall R. Filamin A regulates caveolae internalization and trafficking in endothelial cells. Mol Biol Cell. 2009;20:4531-40 pubmed publisher
    ..Taken together, these data suggest that filamin A association with caveolin-1 promotes caveolae-mediated transport by regulating vesicle internalization, clustering, and trafficking. ..
  48. Fukumoto M, Kurisu S, Yamada T, Takenawa T. α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation. PLoS ONE. 2015;10:e0120616 pubmed publisher
    ..Altogether, our results suggest that ZYX defective binding to ACTN4, which occupies focal adhesions instead of ACTN1, induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion. ..
  49. Kim J, Geyer F, Martelotto L, Ng C, Lim R, Selenica P, et al. MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene. J Pathol. 2017;: pubmed publisher
  50. Berryman M, Bretscher A. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Mol Biol Cell. 2000;11:1509-21 pubmed
    ..These studies suggest that CLIC1, CLIC4, and CLIC5 play distinct roles in chloride transport and that CLIC5 interacts with the cortical actin cytoskeleton in polarized epithelial cells. ..
  51. Chowrashi P, Mittal B, Sanger J, Sanger J. Amorphin is phosphorylase; phosphorylase is an alpha-actinin-binding protein. Cell Motil Cytoskeleton. 2002;53:125-35 pubmed
    ..This resulted in targeting of the fusion protein to Z-bands accompanied by a diffuse pattern in the cytoplasm. ..
  52. Lan S, Wang H, Jiang H, Mao H, Liu X, Zhang X, et al. Direct interaction between alpha-actinin and hepatitis C virus NS5B. FEBS Lett. 2003;554:289-94 pubmed
    ..Studies of the HCV subgenomic replicon system with small interference RNA indicate that alpha-actinin is essential for HCV RNA replication. Our results suggest alpha-actinin may be a component of the HCV replication complex...
  53. Thorsen K, Sørensen K, Brems Eskildsen A, Modin C, Gaustadnes M, Hein A, et al. Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Mol Cell Proteomics. 2008;7:1214-24 pubmed publisher
  54. Snasel J, Pichova I. The cleavage of host cell proteins by HIV-1 protease. Folia Biol (Praha). 1996;42:227-30 pubmed
  55. Bunn R, Jensen M, Reed B. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Mol Biol Cell. 1999;10:819-32 pubmed
  56. Greene D, Tumova S, Couchman J, Woods A. Syndecan-4 associates with alpha-actinin. J Biol Chem. 2003;278:7617-23 pubmed
    ..We now demonstrate by Triton X-100 extraction immunoprecipitation and in vitro binding assays that the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner. ..
  57. Murphy A, Young P. The actinin family of actin cross-linking proteins - a genetic perspective. Cell Biosci. 2015;5:49 pubmed publisher
    ..Observations from both of these areas provide insights into the evolution and cellular functions of actinins. ..
  58. Zeng Y, Zhang L, Zhu W, He H, Sheng H, Tian Q, et al. Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis. Osteoporos Int. 2017;28:3033-3042 pubmed publisher
    ..Results from transcriptomic and genomic levels provided additional supporting evidences. Our study strongly supports the significance of the genes P4HB, ITGB1, CD36, and ACTN1 to the etiology of osteoporosis risk. ..
  59. Xu Y, Wu R, Gu Y, Yang Y, Yang M, Nwariaku F, et al. Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. J Biol Chem. 2002;277:28051-7 pubmed
    ..We speculate that endothelial cells may target endogenous oxidant production to specific sites critical to cytokine signaling as a mechanism for increasing signal specificity and decreasing toxicity of these reactive species. ..
  60. Burgueno J, Blake D, Benson M, Tinsley C, Esapa C, Canela E, et al. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. J Biol Chem. 2003;278:37545-52 pubmed
    ..These findings suggest an alpha-actinin-dependent association between the actin cytoskeleton and A2AR trafficking. ..
  61. Chen V, Li X, Perreault H, Nagy J. Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins. J Proteome Res. 2006;5:2123-34 pubmed
  62. Bauer K, Kratzer M, Otte M, de Quintana K, Hagmann J, Arnold G, et al. Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells. Blood. 2000;96:4236-45 pubmed
    ..The study suggests that CLP36 may direct alpha-actinin-1 to specific actin structures and at this position might modulate the function of alpha-actinin-1. (Blood. 2000;96:4236-4245) ..
  63. Lin S, Raval S, Zhang Z, Deverill M, Siminovitch K, Branch D, et al. The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin. J Biol Chem. 2004;279:25755-64 pubmed
  64. Craig D, Haimovich B, Basson M. Alpha-actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction. Am J Physiol Cell Physiol. 2007;293:C1862-74 pubmed
  65. Yasutomi M, Kunishima S, Okazaki S, Tanizawa A, Tsuchida S, Ohshima Y. ACTN1 rod domain mutation associated with congenital macrothrombocytopenia. Ann Hematol. 2016;95:141-4 pubmed publisher
    ..Our findings suggest a novel mechanism for the pathogenesis of ACTN1-related macrothrombocytopenia that does not involve functional domain mutations. ..
  66. Ogneva I, Biryukov N. Lecithin Prevents Cortical Cytoskeleton Reorganization in Rat Soleus Muscle Fibers under Short-Term Gravitational Disuse. PLoS ONE. 2016;11:e0153650 pubmed publisher
    ..Thus, lecithin prevented the reduction of Actn1 and Actn4 mRNA and the migration of ACTN4 from the cortical cytoskeleton to the cytoplasm. ..
  67. Trulsson M, Yu H, Gisselsson L, Chao Y, Urbano A, Aits S, et al. HAMLET binding to ?-actinin facilitates tumor cell detachment. PLoS ONE. 2011;6:e17179 pubmed publisher
    ..As ?-actinins also associate with signaling molecules, cytoplasmic domains of transmembrane receptors and ion channels, additional ?-actinin-dependent mechanisms are discussed. ..
  68. Kovac B, Teo J, Makela T, Vallenius T. Assembly of non-contractile dorsal stress fibers requires ?-actinin-1 and Rac1 in migrating and spreading cells. J Cell Sci. 2013;126:263-73 pubmed publisher
    ..Furthermore, we propose that non-contractile dorsal stress fibers promote cell migration and early cell spreading through Rac1-induced actin polymerization...
  69. Ji W, Hatch A, Merrill R, Strack S, Higgs H. Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. elife. 2015;4:e11553 pubmed publisher
    ..We propose that Drp1 is in dynamic equilibrium on mitochondria in a fission-independent manner, and that fission factors such as actin filaments target productive oligomerization to fission sites. ..
  70. Rajamani D, Bhasin M. Identification of key regulators of pancreatic cancer progression through multidimensional systems-level analysis. Genome Med. 2016;8:38 pubmed publisher
  71. Itoh Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Koyanagi T, et al. Titin mutations as the molecular basis for dilated cardiomyopathy. Biochem Biophys Res Commun. 2002;291:385-93 pubmed
    ..These observations suggest that titin mutations may cause DCM in a subset of the patients. ..
  72. Dhavan R, Greer P, Morabito M, Orlando L, Tsai L. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. J Neurosci. 2002;22:7879-91 pubmed
  73. Drmota Prebil S, Slapšak U, Pavšič M, Ilc G, Puž V, de Almeida Ribeiro E, et al. Structure and calcium-binding studies of calmodulin-like domain of human non-muscle α-actinin-1. Sci Rep. 2016;6:27383 pubmed publisher
  74. Egerton M, Moritz R, Druker B, Kelso A, Simpson R. Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes. Biochem Biophys Res Commun. 1996;224:666-74 pubmed
    ..Furthermore, we show that Hsc70 is tyrosine phosphorylated in response to TCR ligation, which constitutes the first evidence that Hsc70 might be subject to regulation by tyrosine kinase signaling pathways. ..
  75. Feng S, Reséndiz J, Christodoulides N, Lu X, Arboleda D, Berndt M, et al. Pathological shear stress stimulates the tyrosine phosphorylation of alpha-actinin associated with the glycoprotein Ib-IX complex. Biochemistry. 2002;41:1100-8 pubmed
  76. Sharma A, Wiederin J, Uz M, Ciborowski P, Mallapragada S, Gendelman H, et al. Proteomic analysis of mesenchymal to Schwann cell transdifferentiation. J Proteomics. 2017;165:93-101 pubmed publisher
    ..Our study was the first proteomic comparison demonstrating the transdifferentiation of MSCs and these reported results can affect a wide field of stem cell biology, tissue engineering, and proteomics. ..
  77. Shoeman R, Kesselmier C, Mothes E, Höner B, Traub P. Non-viral cellular substrates for human immunodeficiency virus type 1 protease. FEBS Lett. 1991;278:199-203 pubmed
  78. Joseph C, Stier G, O Brien R, Politou A, Atkinson R, Bianco A, et al. A structural characterization of the interactions between titin Z-repeats and the alpha-actinin C-terminal domain. Biochemistry. 2001;40:4957-65 pubmed
    ..No cooperative or additional contributions to the interaction were observed for Z-repeat double constructs. These findings have direct relevance for evaluating current models of Z-disk assembly. ..
  79. Zhang Z, Lin S, Neel B, Haimovich B. Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration. J Biol Chem. 2006;281:1746-54 pubmed
    ..These findings uncover a novel feedback loop involving phosphorylated alpha-actinin and PTP 1B that regulates FAK x Src interaction and cell migration. ..
  80. Bausen M, Fuhrmann J, Betz H, O Sullivan G. The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members. Mol Cell Neurosci. 2006;31:376-86 pubmed
    ..Our data suggest that Mena binding to F-actin allows for gephyrin recruitment to the leading edge of uncapped actin filaments. ..
  81. Yang C, Glass W. Expression of alpha-actinin-1 in human glomerular mesangial cells in vivo and in vitro. Exp Biol Med (Maywood). 2008;233:689-93 pubmed publisher
    ..These findings suggest that alpha-actinin-1 may play a role in human glomerular disease. ..
  82. Jevnikar Z, Obermajer N, Pecar Fonović U, Karaoglanovic Carmona A, Kos J. Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding. Eur J Immunol. 2009;39:3217-27 pubmed publisher
    ..Gradual cleavage of LFA-1 by cathepsin X enables the transition between intermediate and high affinity LFA-1, an event that is crucial for effective T-cell migration. ..
  83. Chi R, Simon A, Bienkiewicz E, Felix A, Keller T. Smooth muscle titin Zq domain interaction with the smooth muscle alpha-actinin central rod. J Biol Chem. 2008;283:20959-67 pubmed publisher
    ..We present a model in which two sm-titin Zq domains interact with each other and with the two R2-R3 sites in the alpha-actinin central rod. ..
  84. Alberico E, Zhu Z, Wu Y, Gardner M, Kovar D, Goodson H. Interactions between the Microtubule Binding Protein EB1 and F-Actin. J Mol Biol. 2016;428:1304-1314 pubmed publisher
  85. Mukai H, Toshimori M, Shibata H, Takanaga H, Kitagawa M, Miyahara M, et al. Interaction of PKN with alpha-actinin. J Biol Chem. 1997;272:4740-6 pubmed
    ..We therefore propose that PKN is linked to the cytoskeletal network via a direct association between PKN and alpha-actinin. ..
  86. Hirooka S, Akashi T, Ando N, Suzuki Y, Ishida N, Kurata M, et al. Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas. Pathobiology. 2011;78:10-23 pubmed publisher
    ..Ect2 was a possible regulator of matrix-contact-side localization of invadopodia-related proteins. ..
  87. de Graaff M, de Jong D, Briaire de Bruijn I, Hogendoorn P, Bovée J, Szuhai K. A translocation t(6;14) in two cases of leiomyosarcoma: Molecular cytogenetic and array-based comparative genomic hybridization characterization. Cancer Genet. 2015;208:537-44 pubmed publisher
    ..The other identified breakpoints appeared to be non-recurrent, because they were not detected in other leiomyosarcomas, uterine leiomyomas, undifferentiated spindle cell sarcomas, or undifferentiated pleomorphic sarcomas. ..
  88. Wang J, Yu L, Huang X, Wang Y, Zhao J. Comparative proteome analysis of saccular intracranial aneurysms with iTRAQ quantitative proteomics. J Proteomics. 2016;130:120-8 pubmed publisher
    ..The iTRAQ technology provides scientific foundation for the further study to explore the pathogenic mechanism of sIAs. ..
  89. Nebl T, Pestonjamasp K, Leszyk J, Crowley J, Oh S, Luna E. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem. 2002;277:43399-409 pubmed
    ..We suggest that the DRM-H fraction represents a membrane skeleton-associated subset of leukocyte signaling domains. ..
  90. Yamaji S, Suzuki A, Kanamori H, Mishima W, Yoshimi R, Takasaki H, et al. Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. J Cell Biol. 2004;165:539-51 pubmed
  91. Park J, Kim J, Kim Y, Ha S, Yoo J, Du G, et al. Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner. J Biol Chem. 2000;275:21295-301 pubmed
    ..These results suggest that PLD2 is reciprocally regulated in sarcolemmal membranes by alpha-actinin and ARF1 and accordingly that a major role for PLD2 in cardiac function may involve reorganization of the actin cytoskeleton. ..
  92. Frey N, Richardson J, Olson E. Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc Natl Acad Sci U S A. 2000;97:14632-7 pubmed
    ..Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. ..