ALOX5

Summary

Gene Symbol: ALOX5
Description: arachidonate 5-lipoxygenase
Alias: 5-LO, 5-LOX, 5LPG, LOG5, arachidonate 5-lipoxygenase, LOX-5, arachidonic 5-lipoxygenase alpha-10 isoform, arachidonic 5-lipoxygenase delta-10-13 isoform, arachidonic 5-lipoxygenase delta-13 isoform, arachidonic 5-lipoxygenase delta-p10 isoform, arachidonic acid 5-lipoxygenase, leukotriene A4 synthase
Species: human

Top Publications

  1. doi Homology modeling of 5-lipoxygenase and hints for better inhibitor design
    P Aparoy
    School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India
    J Comput Aided Mol Des 22:611-9. 2008
  2. ncbi Use of simplified substrates for the study of 5-lipoxygenase from RBL-1 cells
    J F Nave
    Merrell Dow Research Institute, Strasbourg, France
    Prostaglandins 36:385-98. 1988
  3. ncbi Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes
    P J Jakobsson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Eur J Biochem 232:37-46. 1995
  4. ncbi Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis
    James H Dwyer
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA 91803 8000, USA
    N Engl J Med 350:29-37. 2004
  5. ncbi Regulation of COX and LOX by curcumin
    Chinthalapally V Rao
    Hematology Oncology Section, University of Oklahoma Cancer Institute, Oklahoma City 73104, USA
    Adv Exp Med Biol 595:213-26. 2007
  6. doi Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase
    Andreas Koeberle
    Department of Pharmaceutical Analytics, Pharmaceutical Institute, Eberhard Karls University Tuebingen, Auf der Morgenstelle 8, D 72076 Tuebingen, Germany
    J Med Chem 51:8068-76. 2008
  7. pmc Cytotoxic effect of HIV-1 coat glycoprotein gp120 on human neuroblastoma CHP100 cells involves activation of the arachidonate cascade
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    Biochem J 333:45-9. 1998
  8. ncbi The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis
    J T Studýnková
    Institute of Rheumatology, Prague, Czech Republic
    Clin Exp Rheumatol 22:395-402. 2004
  9. doi The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis
    Marino Venerito
    Department of Gastroenterology, Hepatology, Infectious Diseases, Otto von Guericke University Hospital, Leipziger Str 44, D 39120 Magdeburg, Germany
    Cancer Lett 270:218-28. 2008
  10. pmc Cloning of the cDNA for human 5-lipoxygenase
    R A Dixon
    Department of Virus, Merck Sharp and Dohme Research Laboratories, West Point, PA 19486
    Proc Natl Acad Sci U S A 85:416-20. 1988

Research Grants

  1. Sex Differences in Opioid Analgesia
    Anne Murphy; Fiscal Year: 2006
  2. Variation in the ALOX5 gene and response to omega-3 fatty acid supplements
    Charles Stephensen; Fiscal Year: 2007
  3. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
  4. Identification of novel target genes for polycythemia vera (PV)
    Shaoguang Li; Fiscal Year: 2013
  5. NOVEL THERAPEUTIC AGENTS FOR MYOCARDIAL INFARCTION
    Robert Zipkin; Fiscal Year: 1990
  6. Charles R Sanders; Fiscal Year: 2016
  7. Marcia E Newcomer; Fiscal Year: 2014
  8. Claus Schneider; Fiscal Year: 2015
  9. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
  10. Anti-inflammatory mechanisms, pharmacokinetics of novel metabolites of vitamin E
    Qing Jiang; Fiscal Year: 2012

Detail Information

Publications254 found, 100 shown here

  1. doi Homology modeling of 5-lipoxygenase and hints for better inhibitor design
    P Aparoy
    School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India
    J Comput Aided Mol Des 22:611-9. 2008
    ..Our results correlated well with the experimental data reported earlier, which proved the quality of the model. This model generated can be further used for the design and development of more potent 5-LOX inhibitors...
  2. ncbi Use of simplified substrates for the study of 5-lipoxygenase from RBL-1 cells
    J F Nave
    Merrell Dow Research Institute, Strasbourg, France
    Prostaglandins 36:385-98. 1988
    ..acid (5-HPETE), are not further processed into leukotrienes by the leukotriene A4 synthase activity of 5-lipoxygenase...
  3. ncbi Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes
    P J Jakobsson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Eur J Biochem 232:37-46. 1995
    ..In contrast, neither human peripheral T-lymphocytes nor Jurkat cells were stained. These results suggest that 5-lipoxygenase and its products function in the nucleus of B-lymphocytes...
  4. ncbi Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis
    James H Dwyer
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA 91803 8000, USA
    N Engl J Med 350:29-37. 2004
    ....
  5. ncbi Regulation of COX and LOX by curcumin
    Chinthalapally V Rao
    Hematology Oncology Section, University of Oklahoma Cancer Institute, Oklahoma City 73104, USA
    Adv Exp Med Biol 595:213-26. 2007
    ..In this review, we discuss evidence that supports the regulation of COX and LOX enzymes by curcumin as the key mechanism for its beneficial effects in preventing various inflammatory diseases...
  6. doi Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase
    Andreas Koeberle
    Department of Pharmaceutical Analytics, Pharmaceutical Institute, Eberhard Karls University Tuebingen, Auf der Morgenstelle 8, D 72076 Tuebingen, Germany
    J Med Chem 51:8068-76. 2008
    ..Taken together, these pirinixic acid derivatives constitute a novel class of dual mPGES-1/5-LO inhibitors with a promising pharmacological profile and a potential for therapeutic use...
  7. pmc Cytotoxic effect of HIV-1 coat glycoprotein gp120 on human neuroblastoma CHP100 cells involves activation of the arachidonate cascade
    M Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata 135, I 00133 Rome, Italy
    Biochem J 333:45-9. 1998
    ..This suggests that NO might participate in the mechanism by which gp120 activates the arachidonate cascade...
  8. ncbi The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis
    J T Studýnková
    Institute of Rheumatology, Prague, Czech Republic
    Clin Exp Rheumatol 22:395-402. 2004
    ....
  9. doi The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis
    Marino Venerito
    Department of Gastroenterology, Hepatology, Infectious Diseases, Otto von Guericke University Hospital, Leipziger Str 44, D 39120 Magdeburg, Germany
    Cancer Lett 270:218-28. 2008
    ..These results suggest an involvement of the COX-LOX pathway in gastric carcinogenesis...
  10. pmc Cloning of the cDNA for human 5-lipoxygenase
    R A Dixon
    Department of Virus, Merck Sharp and Dohme Research Laboratories, West Point, PA 19486
    Proc Natl Acad Sci U S A 85:416-20. 1988
    ..Thus, 5-LO appears to be a member of a larger family of related enzymes...
  11. pmc Expression of 5-lipoxygenase in differentiating human skin keratinocytes
    U Janssen-Timmen
    Department of Internal Medicine, University of Heidelberg, Medical School, Germany
    Proc Natl Acad Sci U S A 92:6966-70. 1995
    ..These results show that 5-LO gene expression is an intrinsic property of human skin keratinocytes...
  12. pmc 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes
    J W Woods
    Department of Biochemical and Molecular Pathology, Merck Research Laboratories, Rahway, New Jersey 07065
    J Exp Med 178:1935-46. 1993
    ....
  13. ncbi Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence
    T G Brock
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0652, USA
    J Biol Chem 272:8276-80. 1997
    ..Nuclear import of 5-lipoxygenase may be a universal accompaniment of neutrophil recruitment into sites of inflammation, and this may be associated with alterations in enzymatic function...
  14. pmc 5-Lipoxygenase expression in Langerhans cells of normal human epidermis
    R Spanbroek
    Division of Carcinogenesis and Differentiation, German Cancer Research Center, Heidelberg, Germany
    Proc Natl Acad Sci U S A 95:663-8. 1998
    ..These data show that naive LCs are major, and possibly the sole, 5-LO pathway expressing cells in the normal human epidermis...
  15. ncbi 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension
    L Wright
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Respir Crit Care Med 157:219-29. 1998
    ....
  16. pmc 5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue
    Rene Hennig
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Pathol 161:421-8. 2002
    ..These findings provide further evidence of up-regulation of this pathway in pancreatic cancer and that LOX inhibitors are likely to be valuable in the treatment of this dreadful disease...
  17. ncbi Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population
    I Sayers
    Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton, UK
    Clin Exp Allergy 33:1103-10. 2003
    ..5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma...
  18. ncbi Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors
    Rikio Yoshimura
    Department of Urology, Osaka City University Medical School, 1 4 3 Asahi machi, Abenoku, Osaka 545 8585, Japan
    J Urol 170:1994-9. 2003
    ..They are now believed to have important roles in tumor promotion, progression and metastasis. The involvement of lipoxygenase expression and function in tumor growth and metastasis has been reported in human tumor cell lines...
  19. ncbi Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase
    Jeong Hee Choi
    Department of Allergy and Rheumatology, Ajou University Hospital, Ajou, Republic of Korea
    Hum Genet 114:337-44. 2004
    ..The single-base extension method was used to genotype SNPs in 5-lipoxygenase (ALOX5, -1708G-->A, 21C-->T, 270G-->A, 1728G-->A), ALOX5-activating protein (ALOX5AP, 218A-->G), ..
  20. ncbi Relationship between lipoxygenase and human testicular cancer
    Rikio Yoshimura
    Department of Urology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Int J Mol Med 13:389-93. 2004
    ..The LOX inhibitors inhibited the growth of TC cells. LOX is induced in TC, and results may suggest that LOXs are essential for cell growth of TC cells...
  21. ncbi Association between 5-lipoxygenase expression and plaque instability in humans
    Francesco Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Arterioscler Thromb Vasc Biol 25:1665-70. 2005
    ..Thus, the aims of this study was to analyze the expression of 5-LO in human carotid plaques and to investigate the mechanism by which this enzyme could lead to plaque instability and rupture...
  22. pmc Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells
    Oliver Werz
    Institutes of Pharmaceutical Chemistry and Organic Chemistry, University of Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    Proc Natl Acad Sci U S A 102:13164-9. 2005
    ..We suggest that splitting of BL41-E95-A cells induces de novo synthesis of a protein involved in the activation of casp-6, which cleaves 5-LO...
  23. pmc Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
    Hong Qiu
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:8161-6. 2006
    ..The abundant expression of LTA4H and correlation with plaque instability identify LTA4H as a potential target for pharmacological intervention in treatment of human atherosclerosis...
  24. ncbi The coding sequence mediates induction of 5-lipoxygenase expression by Smads3/4
    Sabine Seuter
    Institute of Pharmaceutical Chemistry ZAFES, University of Frankfurt, Max von Laue Str 9, D 60438 Frankfurt, Germany
    Biochem Biophys Res Commun 348:1403-10. 2006
    ..Sequence analysis and deletion studies indicate the existence of up to four Smad binding elements and at least one TGFbeta responsive element far downstream of the transcriptional start site...
  25. pmc Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production
    Marija Rakonjac
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:13150-5. 2006
    ..Furthermore, in stimulated cells, CLP appears to function in a complex together with 5LO and membranes, increasing the capacity of 5LO for leukotriene biosynthesis...
  26. ncbi Expanding expression of the 5-lipoxygenase/leukotriene B4 pathway in atherosclerotic lesions of diabetic patients promotes plaque instability
    Yi Jun Zhou
    Department of Endocrinology and Metabolism, Fourth Affiliated Hospital, China Medical University, Shenyang 110032, PR China
    Biochem Biophys Res Commun 363:30-6. 2007
    ..Hence, anti-LTs may be useful, not only in reducing atherogenesis, but also in the prevention and treatment of acute atherothrombotic events in diabetic patients...
  27. ncbi The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes
    Nicole Schnur
    Institute of Pharmaceutical Chemistry ZAFES, University of Frankfurt, Max von Laue Str 9, D 60438 Frankfurt, Germany
    Biochim Biophys Acta 1771:1271-82. 2007
    ..This is the first report demonstrating that Sp3 is involved in the regulation of 5-LO promoter activity. In summary, we show that TsA increases 5-LO promoter activity by the enhanced recruitment of Sp1 and Sp3 to the 5-LO promoter...
  28. pmc Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction
    Hooman Allayee
    Department of Preventive Medicine and the Institute for Genetic Medicine, The University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9075, USA
    Am J Clin Nutr 88:934-40. 2008
    ..We previously reported that variants of a 5-LO promoter repeat polymorphism were associated with carotid atherosclerosis in humans, an effect that was exacerbated by high dietary AA but mitigated by high dietary n-3 fatty acids...
  29. doi Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model
    Laleh G Melstrom
    Department of Surgery and Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Clin Cancer Res 14:6525-30. 2008
    ..The purpose of this study was to evaluate the expression of 5-LOX in colonic polyps and cancer and the effect of 5-LOX inhibition on colon cancer cell proliferation...
  30. pmc High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes
    Yilmaz Mahshid
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    BMC Immunol 10:2. 2009
    ..In order to better understand and define the role of 5-LO in B cells, we investigated the expression of 5-LO mRNA and protein in subsets of B cells from human tonsils and different types of B cell lymphoma...
  31. pmc Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
    Karina Roxana Gheorghe
    Department of Biosciences and Nutrition, Novum, Karolinska Institute, SE 141 57 Huddinge, Sweden
    Arthritis Res Ther 11:R83. 2009
    ..We therefore aimed to investigate the 5-LO and 15-LO-1 expression pattern in RA and ostheoarthritis (OA) synovial tissue and to study the effect of intraarticular glucocorticoid (GC) therapy on enzyme expression...
  32. pmc A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase
    Qi Wang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, PR China
    Neoplasia 12:103-15. 2010
    ..Thus, our finding provides a new insight into the mechanism involving the promotion of cell growth mediated by HBxDelta127...
  33. doi Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products
    Luc H Boudreau
    Département de Chimie et Biochimie Université de Moncton, Moncton, NB, E1A 3E9, Canada
    FASEB J 25:1097-105. 2011
    ..These alternative 5-LO isoforms may represent a new mechanism for the regulation of the 5-LO pathway and lipid mediator biosynthesis...
  34. doi 5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1
    Seung Jin Lee
    Department of Pharmacology, School of Medicine, Pusan National University, Yangsan, Gyeongnam, Korea
    Cardiovasc Res 99:724-33. 2013
    ....
  35. pmc Expression of 5-lipoxygenase in human colorectal cancer
    Labile Togba Soumaoro
    Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    World J Gastroenterol 12:6355-60. 2006
    ..To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis...
  36. ncbi Cholesterol-dependent modulation of the toxicity of HIV-1 coat protein gp120 in human neuroblastoma cells
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 82:1444-52. 2002
    ..Taken together, these results suggest that membrane fluidity may control the neurotoxic effects of HIV-1 glycoprotein gp120...
  37. pmc Formation of a cyclopropyl epoxide via a leukotriene A synthase-related pathway in an anaerobic reaction of soybean lipoxygenase-1 with 15S-hydroperoxyeicosatetraenoic acid: evidence that oxygen access is a determinant of secondary reactions with fatty ac
    Yuxiang Zheng
    Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 285:13427-36. 2010
    ..Our results support a model in which access to molecular oxygen within the active site directs the outcome from competing pathways in the secondary reactions of lipoxygenases...
  38. ncbi Modulation of human marrow haematopoiesis by leucotrienes in vitro
    Z Estrov
    Division of Haematology Oncology, Hospital for Sick Children, Toronto, Canada
    Br J Haematol 69:321-7. 1988
    ..Our studies show that the 5-LO pathway is functional in these culture systems and yields products with inhibitory properties. The 5-LO pathway may have an important regulatory function in normal marrow haematopoiesis...
  39. ncbi 12-Lipoxygenase from bovine polymorphonuclear leukocytes, an enzyme with leukotriene A4-synthase activity
    P Walstra
    Department of Bio Organic Chemistry, State University of Utrecht, The Netherlands
    Biochem Biophys Res Commun 149:258-65. 1987
    ..Hence, the 12-lipoxygenase from bovine polymorphonuclear leukocytes possesses leukotriene A4-synthase activity...
  40. ncbi Cardioprotective effect of 5-lipoxygenase gene (ALOX5) silencing in ischemia-reperfusion
    Oleksandr O Lisovyy
    Department of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Acta Biochim Pol 56:687-94. 2009
    ..Therefore, the gene encoding arachidonate 5-lipoxygenase (ALOX5) appears to be an attractive target for RNA interference (RNAi) application...
  41. pmc Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
    Yaoyu Chen
    Division of Hematology Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Nat Genet 41:783-92. 2009
    ..Here we identify the arachidonate 5-lipoxygenase (5-LO) gene (Alox5) as a critical regulator for leukemia stem cells (LSCs) in BCR-ABL-induced chronic myeloid leukemia (CML)...
  42. ncbi Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival
    Sathish Sundaram
    Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI 48202, USA
    Biochem Biophys Res Commun 339:93-8. 2006
    ....
  43. ncbi Isocratic determination of arachidonic acid 5-lipoxygenase products in human neutrophils by high-performance liquid chromatography
    H Mita
    Clinical Research Centre for Rheumato Allergology, National Sagamihara Hospital, Kanagawa, Japan
    J Chromatogr 430:299-308. 1988
    ..The generation and degradation of 5-lipoxygenase products by human neutrophils following stimulation with calcium ionophore have been examined by this method...
  44. ncbi Biosynthesis of peptidyl leukotrienes and other lipoxygenase products by rat pancreatic islets. Comparison with macrophages and neutrophils
    R O Morgan
    Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298
    Prostaglandins 35:609-23. 1988
    ..The stimulus-specific nature of leukotriene biosynthesis was characterized by low basal biosynthesis in unstimulated islet cells with a calcium-mediated activation of 5-lipoxygenase product formation...
  45. doi Pharmacological evaluation of Alstonia scholaris: anti-inflammatory and analgesic effects
    Jian Hua Shang
    Yunnan Institute of Medical Material, Kunming, PR China
    J Ethnopharmacol 129:174-81. 2010
    ..The leaf extract, developed as a commercially available traditional Chinese medicine, used to release tracheitis and cold symptom, has also been prescribed in hospitals and sold over the counter in drug stores...
  46. ncbi Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 50:3925-33. 2004
    ....
  47. pmc Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Br J Pharmacol 139:1351-9. 2003
    ....
  48. pmc Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation
    Barry M Markaverich
    Department of Molecular and Cellular Biology, Baylor Colloege of Medicine, Houston, TX 77030, USA
    Environ Health Perspect 115:1727-31. 2007
    ..Synthetic THF-diols inhibited rat male and female sexual behavior at oral concentrations of 0.5-1 ppm, and stimulated MCF-7 human breast cancer cell proliferation in vitro...
  49. doi Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors
    Morshed Alam Chowdhury
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta, Canada T6G 2N8
    Bioorg Med Chem Lett 18:4195-8. 2008
    ..4 mg/kg). The N-hydroxypyridin-2(1H)one moiety provides a novel pharmacophore for the design of cyclic hydroxamic mimetics capable of chelating 5-LOX iron for exploitation in the design of 5-LOX inhibitory AI drugs...
  50. ncbi [Partially hydrogenated aryl-1,2/1,4-anthraquinone derivatives, 5-lipoxygenase inhibitors with arotinoid structure]
    G Wurm
    Institut fur Pharmazie, Freien Universitat Berlin, Germany
    Pharmazie 56:527-33. 2001
    ..All compounds are devoid of any activity in cell differentiation as compared to retinoic acid as indicated by the NBT test with HL-60 leukemia cells...
  51. pmc Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages
    D Altavilla
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Br J Pharmacol 157:1410-8. 2009
    ..The anti-inflammatory activity, measured by protein and gene expression of inflammatory markers, of flavocoxid in rat peritoneal macrophages stimulated with Salmonella enteritidis lipopolysaccharide (LPS) was investigated...
  52. ncbi Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin
    Sohei Ito
    Department of Pharmacology, Kitasato University of Medicine, Kanagawa, Japan
    Shock 30:87-91. 2008
    ..These findings suggest that the LTB4/BLT1 pathway mediates hepatic microcirculatory dysfunction by enhanced expression of ICAM-1 and TNF-[alpha] in a murine model of endotoxemia...
  53. ncbi Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow
    H Ulbrich
    Karolinska Institute, Department of Physiology and Pharmacology, Von Eulers Vag 8, SE 171 77 Stockholm, Sweden
    Biochem Pharmacol 70:30-6. 2005
    ..Thus, the novel 5-LOX/COX inhibitor licofelone possesses anti-inflammatory activity that, in addition to COX/LOX inhibition, involves effects on leukocyte-endothelial interactions...
  54. doi 5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts
    Christelle Vincent
    Universite de Limoges, Centre National de la Recherche Scientifique, CNRS UMR 6101, Faculte de Medecine, 2 rue Dr Marcland, 87025 Limoges, France
    Leuk Res 32:1756-62. 2008
    ..We may speculate that LTB(4)-derived blast cells might initiate, augment or prolong tissue inflammation and damages by affecting the marrow and blood cytokine network...
  55. doi Pathogenic importance of cysteinyl leukotrienes in development of gastric lesions induced by ischemia/reperfusion in mice
    Yuka Nakamori
    Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8414, Japan
    J Pharmacol Exp Ther 333:91-8. 2010
    ....
  56. doi Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
    Hyunmin Song
    School of Pharmacy, Ewha Womans University, Seoul 120 750, Republic of Korea
    Bioorg Med Chem 18:7580-5. 2010
    ..Fourteen compounds prepared showed the inhibition of LTC4 formation with IC(50) value of 0.12-23.88 μM. Also two compounds 2d and 2g showed improved airway hypersensitiveness...
  57. ncbi Dual acting anti-inflammatory drugs
    S Leone
    Division of Clinical Pharmacology, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Curr Top Med Chem 7:265-75. 2007
    ..Leukocyte 15-LOX and platelet 12-LOX by intercellular mechanism via leukocyte/platelet cell-cell interaction convert 15-HPETE into lipoxins...
  58. doi Pharmacophore modeling and virtual screening for designing potential 5-lipoxygenase inhibitors
    P Aparoy
    School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India
    Bioorg Med Chem Lett 20:1013-8. 2010
    ..These studies thus validate the pharmacophore model generated and suggest the usefulness of the model in screening of various small molecule libraries and identification of potential lead compounds for 5-LOX inhibition...
  59. ncbi Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephron
    Stephan W Reinhold
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 290:F864-72. 2006
    ..Our data suggest that the glomerulus is a major source and target for 5- and 12-HETE and for leukotrienes. The collecting duct system, on the other hand, appears to be a major source of 15-HETE...
  60. doi Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin
    Ján Kleban
    Institute of Biology and Ecology, Faculty of Sciences, P J Safarik University, Moyzesova 11, 041 65 Kosice, Slovakia
    J Photochem Photobiol B 93:108-18. 2008
    ..Interestingly, pre-treatment with MK-886 modulated distribution of ROS production in mutual combination with PDT...
  61. doi CoMFA and CoMSIA studies on 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase inhibitors: generation of homology model and docking studies
    P Aparoy
    School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India
    Bioorg Med Chem Lett 21:456-62. 2011
    ..The 3D-QSAR models were compared with the interactions at the active site to further elucidate the accuracy of the models. The data generated from 3D-QSAR study was used to design potential 5-LOX inhibitors...
  62. ncbi Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs
    Caroline Charlier
    Lab de Chimie Moléculaire Structurale, Facultes Universitaires N D de la Paix, Rue de Bruxelles 61, B 5000, Namur, Belgium
    Eur J Med Chem 38:645-59. 2003
    ..In this review, COX and 5-LOX pathways are first described in order to highlight the therapeutic interest of designing such compounds. Various structural families of dual inhibitors are illustrated...
  63. ncbi Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line (MBT-2)
    Shinichi Ikemoto
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Anticancer Res 24:733-6. 2004
    ..In an in vivo experiment, the antitumor effects of baicalein administration on C3H/HeN mice implanted with MBT-2 were recognized. These results suggested that LOX inhibition may be significant in the treatment of bladder cancer...
  64. doi A cell-based assay for screening lipoxygenase inhibitors
    Dileep G Nair
    Department of Physiology and Biochemistry, Queen s University, Kingston, ON, Canada
    Prostaglandins Other Lipid Mediat 90:98-104. 2009
    ....
  65. ncbi 5-lipoxygenase and cyclooxygenase regulate wound closure in NIH/3T3 fibroblast monolayers
    J Angelo Green
    Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Am J Physiol Cell Physiol 287:C373-83. 2004
    ..These data suggest that two competing oxidative enzymes in arachidonate metabolism, LOX and COX, differentially regulate sequential aspects of fibroblast wound closure in vitro...
  66. ncbi Anti-inflammatory activity of myricetin-3-O-beta-D-glucuronide and related compounds
    A Hiermann
    Institute of Pharmacognosy, University of Graz, Austria
    Inflamm Res 47:421-7. 1998
    ..The anti-inflammatory effect of myricetinglucuronide (MGL) was investigated and structurally-related compounds were compared to examine the structure/activity-relationship in carrageenan-induced rat paw edema...
  67. pmc Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat
    Dong Won Lee
    Department of Internal Medicine, Pusan National University School of Medicine, Seo Gu, Busan, Korea
    J Korean Med Sci 24:S183-8. 2009
    ..The present study suggested that celecoxib and NDGA might effectively reduce proteinuria in nephrotic syndrome without impairing renal function...
  68. ncbi Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability
    R Jaggi
    VitaPlant AG, Benkenstrasse 254, 4108 Witterswil, Switzerland
    Inflamm Res 53:150-7. 2004
    ..N and its constituents, the inhibition of the synthesis of Leukotriene B4 (LTB4) and Prostaglandin (PGE2) by 5-lipoxygenase (5-LOX) and cyclo-oxygenase 1 and 2 (COX 1 and 2) respectively were examined in vitro...
  69. ncbi Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells
    Ján Kleban
    Institute of Biology and Ecology, Faculty of Sciences, P J Safarik University, Kosice, Slovakia
    Photochem Photobiol 83:1174-85. 2007
    ..In conclusion, our results testify that application of diverse inhibitors of AA metabolism may have different consequences on cellular response to hypericin-mediated PDT and that some of them could be considered for potentiation of PDT...
  70. doi [Inhibiting cyclooxygenase and 5-lipoxygenase activities is an anti-inflammatory mechanism of Huzhang Gout Granule]
    Yi Fei Wang
    Gout Clinic, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    Zhong Xi Yi Jie He Xue Bao 7:963-8. 2009
    ....
  71. ncbi Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity
    Ana María Díaz
    Department of Pharmacology, Faculty of Pharmacy, University Alcala, Alcala de Henares, 28871 Madrid, Spain
    Life Sci 74:2515-26. 2004
    ..These results indicate that the pharmacology of these compounds may participate in the anti-inflammatory effect of Scrophularia scorodonia...
  72. ncbi A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation
    B P Burnett
    Primus Pharmaceuticals, Inc, Scottsdale, AZ 85251, USA
    J Med Food 10:442-51. 2007
    ..These results suggest that this natural, flavonoid mixture acts via "dual inhibition" of COX and LOX enzymes to reduce production of pro-inflammatory eicosanoids and attenuate edema in an in vivo model of inflammation...
  73. pmc Prevalence of common disease-associated variants in Asian Indians
    Trevor J Pemberton
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    BMC Genet 9:13. 2008
    ....
  74. ncbi Design, synthesis and pharmacological evaluation of novel tetrasubstituted thiophene analogues as anti-inflammatory agents
    Khurshid I Molvi
    School of Pharmacy, Faculty of Medical Sciences, Jimma University, Jimma, Ethiopia
    J Enzyme Inhib Med Chem 23:819-28. 2008
    ....
  75. doi Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory ac
    Morshed A Chowdhury
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta, Canada T6G 2N8
    Bioorg Med Chem Lett 19:6855-61. 2009
    ..The N-difluoromethyl-1,2-dihydropyridin-2-one moiety provides a novel 5-LOX pharmacophore for the design of cyclic hydroxamic mimetics for exploitation in the development of dual COX-2/5-LOX inhibitory AI drugs...
  76. doi Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors
    Nimmanapalli P Reddy
    School of Life Sciences, University of Hyderabad, Hyderabad, India
    Bioorg Med Chem 18:5807-15. 2010
    ..Further, the compound 5e showed potent anti-proliferative effects (GI(50) at 9 microM) on breast cancer cell line, MCF-7...
  77. ncbi Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton
    Marika Collin
    Centre for Experimental Medicine, Nephrology and Critical Care, The William Harvey Research Institute, Queen Mary, University of London, UK
    J Leukoc Biol 76:961-70. 2004
    ....
  78. doi The in vitro biological activity of selected South African Commiphora species
    M P Paraskeva
    Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa
    J Ethnopharmacol 119:673-9. 2008
    ..55+/-2.01 and 71.45+/-1.24 microg/ml. The majority of the Commiphora extracts were largely non-cytotoxic against Graham human kidney epithelial cells when investigated in the MTT assay...
  79. ncbi Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae)
    Rachel W Li
    Australian Centre for Complementary Medicine Education and Research, A Joint Venture of the University of Queensland and Southern Cross University, P O Box 157, Lismore, NSW 2480, Australia
    J Ethnopharmacol 104:138-43. 2006
    ..5, 101.2 and 29.3 microg/mL. One of its fractions also significantly elevated PPARalpha expression by 173, 280 and 435% and PPARgamma expression by 140, 228 and 296% at 4, 8 and 16 microg/mL, respectively...
  80. doi 5-lipoxygenase-inhibitory constituents from Schizandra fructus and Magnolia flos
    Hyun Lim
    College of Pharmacy, Kangwon National University, Chunchon, Korea
    Phytother Res 23:1489-92. 2009
    ..These compounds have the potential to be developed as novel antiallergic agents and may contribute to the antiallergic pharmacological use of these plant materials in Chinese medicine...
  81. doi Minocycline inhibits 5-lipoxygenase expression and accelerates functional recovery in chronic phase of focal cerebral ischemia in rats
    Li Sheng Chu
    Department of Pharmacology, School of Medicine, Zhejiang University, 388 Yuhangtang Road, Hangzhou, 310058, Zhejiang, PR China
    Life Sci 86:170-7. 2010
    ..Here, we determined the protective effect of minocycline on chronic ischemic brain injury and its relation with the inhibition of 5-LOX expression after focal cerebral ischemia...
  82. ncbi Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers
    Julio J Ochoa
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, C Ramon y Cajal 4, 18071, Granada, Spain
    Carcinogenesis 25:1185-91. 2004
    ..Trans-10, cis-12 seems to work preferentially through modulation of apoptosis and cell cycle control, while c9,t11 CLA isomer affects arachidonic acid metabolism...
  83. ncbi Non-prostaglandin eicosanoids in fever and anapyrexia
    Wieslaw Kozak
    Department of Immunology, Institute of General and Molecular Biology, Faculty of Biology and Earth Sciences, Nicolas Copernicus University, 87 100 Torun, Poland
    Front Biosci 9:3339-55. 2004
    ..COX, 5-LOX, and epoxygenase products may act at the level of hypothalamus as proximal mediators of, respectively, fever (PGE2) or cryogenesis (CysLTs and EETs), or indirectly by influencing the other endogenous cryogens and pyrogens...
  84. ncbi IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Eur J Immunol 37:3373-80. 2007
    ....
  85. ncbi Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells
    Clemence Lepage
    Universite de Limoges, Institut GEIST, EA 4021, Biomolécules et thérapies anti tumorales, Laboratoire de Biochimie, 87025 Limoges Cedex, France
    Int J Oncol 36:1183-91. 2010
    ....
  86. pmc Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults
    Irina Costea
    Public Health Agency of Canada, Montreal, Canada
    PLoS ONE 5:e15672. 2010
    ..We hypothesized that inherited variation in key PUFA metabolic enzymes may modify susceptibility for CD...
  87. ncbi The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans
    Shanta J Persaud
    Beta Cell Development and Function Group, Division of Reproductive Health, Endocrinology, and Development, King s College London, UK
    Diabetes 56:197-203. 2007
    ....
  88. ncbi The molecular biology and regulation of 5-lipoxygenase
    O P Rådmark
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 161:S11-5. 2000
  89. ncbi Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP
    Andis Klegeris
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada
    J Leukoc Biol 73:369-78. 2003
    ..The data suggest that inhibition of proinflammatory LT production by 5-LOX inhibition could selectively reduce toxicity of microglial cells and thus be beneficial in neuroinflammatory diseases...
  90. ncbi Anti-inflammatory activity of four Bolivian Baccharis species (Compositae)
    M J Abad
    Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain
    J Ethnopharmacol 103:338-44. 2006
    ..Most of the extracts tested were active in all assays...
  91. ncbi Baicalin attenuates oxygen-glucose deprivation-induced injury via inhibiting NMDA receptor-mediated 5-lipoxygenase activation in rat cortical neurons
    Qiu Fu Ge
    Department of Pharmacology, Zhejiang University School of Medicine, 388, Yu Hang Tang Road, Hangzhou 310058, China
    Pharmacol Res 55:148-57. 2007
    ..These results indicate that baicalin attenuates ischemic-like injury in the neurons, and this effect partly relates to the inhibition of NMDA receptor-mediated 5-LOX activation...
  92. pmc Expression of 5-lipoxygenase (5-LOX) in T lymphocytes
    Jeanne M Cook-Moreau
    Laboratoire de Biochimie et Genetique Moleculaire, Faculte de Medecine, Limoges, France
    Immunology 122:157-66. 2007
    ..The presence of 5-LOX in T lymphocytes but the absence of endogenous lipoxygenase metabolite production compared to Jurkat cells may constitute a fundamental difference between resting peripheral lymphocytes and leukaemic cells...
  93. doi Influence of phenolic constituents from Yucca schidigera bark on arachidonate metabolism in vitro
    Eva M Wenzig
    Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria
    J Agric Food Chem 56:8885-90. 2008
    ..The inhibitory activity on key enzymes of arachidonate metabolism observed in this study might contribute to the explanation of the anti-inflammatory and antiplatelet effects observed for Y. schidigera and its phenolic constituents...
  94. pmc Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 447:134-7. 2008
    ..Increased GluR1 phosphorylation and minocycline treatment have been associated with antidepressant and memory-enhancing activities. Direct consequences of minocycline-increased GluR1 phosphorylation are yet to be established...
  95. doi The anti-inflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes
    Raffaella Canali
    National Research Institute for Food and Nutrition, Rome, Italy
    Int Immunopharmacol 9:1145-9. 2009
    ..Here we show for the first time that Pycnogenol supplementation simultaneously inhibits COX-2 and 5-LOX gene expression and reduces leukotriene biosynthesis in human PMNL upon pro-inflammatory stimulation ex vivo...
  96. pmc Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mediators Inflamm 2010:170153. 2010
    Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds.
  97. doi Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity
    Mymoona Akhter
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi, India
    J Enzyme Inhib Med Chem 26:767-76. 2011
    ..Study revealed that these derivatives were more effective than ibuprofen with reduced side effects. It can be suggested that these derivatives could be used to develop more potent and safer NSAIDs...
  98. doi Effects of typheramide and alfrutamide found in Allium species on cyclooxygenases and lipoxygenases
    Jae B Park
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    J Med Food 14:226-31. 2011
    ..Altogether, the data suggest that typheramide and alfrutamide from garlic and green onions are likely to be significant inhibitors for COX 1 and 2 rather than 5- and 12-LOX...
  99. doi Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase
    Yue Li
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, People s Republic of China
    Bioorg Med Chem 19:2074-83. 2011
    ..Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs...
  100. ncbi [Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part I]
    Małgorzata Dzielska-Olczak
    Uniwersytet Medyczny w Łodzi, Zakład Farmakologii Katedry Farmakologii i Farmakologii Klinicznej
    Pol Merkur Lekarski 30:75-81. 2011
    ..Licofelone decreases the production of proinflammatory leucotrienes and prostaglandins. Moreover inhibition of 5-lipooxygenase activity can delay of cartilago degradation...
  101. doi A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population
    Dong Hwan Kim
    Department of Physical Medicine and Rehabilitation, Kyung Hee University, Seoul, Republic of Korea
    Prostaglandins Leukot Essent Fatty Acids 85:115-20. 2011
    ..ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), ..

Research Grants68

  1. Sex Differences in Opioid Analgesia
    Anne Murphy; Fiscal Year: 2006
    ..In summary, these studies will establish that the intrinsic and extrinsic circuitry of the PAG is sexually dimorphic and provide the neural substrate for sex based differences in opioid analgesia. ..
  2. Variation in the ALOX5 gene and response to omega-3 fatty acid supplements
    Charles Stephensen; Fiscal Year: 2007
    ..recent observational data indicates that subjects with a variant allele for the arachidonate 5-lipoxygenase gene (ALOX5) may be at greater risk for cardiovascular disease and, at the same time, may derive a greater benefit from omega-..
  3. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
    ..Moreover, these studies may elucidate ALOX5 expression as a potential biomarker of HIV-PAH disease development and severity...
  4. Identification of novel target genes for polycythemia vera (PV)
    Shaoguang Li; Fiscal Year: 2013
    ..in CML, and we show that the survival and self-renewal of LSCs require the arachidonate 5- lipoxygenase gene (Alox5) and that Alox5 is essential for CML development (Chen et al...
  5. NOVEL THERAPEUTIC AGENTS FOR MYOCARDIAL INFARCTION
    Robert Zipkin; Fiscal Year: 1990
    ..The compounds developed in these studies will greatly increase our knowledge of the structure-activity relationships for LTB4 receptor ligands which may lead to the discovery of novel therapeutic agents...
  6. Charles R Sanders; Fiscal Year: 2016
    ..Specific Aim 2b will elucidate the chemistry, kinetics, and divalent metal ion-dependence of the FosB enzymes with both BSH and the alternative substrate L-Cys. ..
  7. Marcia E Newcomer; Fiscal Year: 2014
    ..The proposed studies will provide both structural and mechanistic information for this key enzyme. ..
  8. Claus Schneider; Fiscal Year: 2015
    ..Novel therapeutic applications of available anti- inflammatory medications are imminent. ..
  9. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
    ....
  10. Anti-inflammatory mechanisms, pharmacokinetics of novel metabolites of vitamin E
    Qing Jiang; Fiscal Year: 2012
    ..The proposed studies will elucidate mechanisms of anti-inflammatory action and generate important preclinical data that are needed to insure maximally informative clinical efficacy studies on these compounds. ..
  11. Gabrielle Fredman; Fiscal Year: 2014
    ..An advisory committee of established scientists/mentors in the fields of resolution, CVD and translational science will guide the candidate in her transition to scientific independence over the course of the award period. ..
  12. Jagadananda Ghosh; Fiscal Year: 2014
    ....
  13. Arun J Sanyal; Fiscal Year: 2015
    ..When these studies are completed, novel information on how alcohol intake modifies systemic LOX activity and the role of such changes in driving liver disease will be obtained. ..
  14. Behavioral consequences of 5-lipoxygenase deficiency
    Radmila Manev; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  15. Use or Metabolomic Markers of Response to Fish Oil Supplementation to Identify Ef
    CHARLES BOLT STEPHENSEN; Fiscal Year: 2011
    ..provided by applicant): We recently completed an NCCAM-funded R21 clinical trial entitled "Variation in the ALOX5 gene and response to omega-3 fatty acid supplements" (R21 AT003411, C. Stephensen, PI;ClinicalTrials...
  16. Type II 11B-Hydroxysteroid Dehydrogenase and Colorectal Tumorigenesis
    Mingzhi Zhang; Fiscal Year: 2013
    ..abstract_text> ..
  17. Soluble epoxide hydrolase as a novel target of colitis-induced carcinogenesis
    Guang Yu Yang; Fiscal Year: 2012
    ....
  18. Gamma-tocopherol as an effective anticancer agent for colon cancer
    Qing Jiang; Fiscal Year: 2010
    ..These studies will also provide biochemical mechanisms and important preclinical data for future human clinical studies. ..
  19. Jason E Lang; Fiscal Year: 2014
    ..There exists evidence that omega-3 fatty acid response displays a pharmacogenetic response related to ALOX5 genotype. Dr...
  20. Lysyl Oxidase Control of TGF-? in Bone
    Mitsuo Yamauchi; Fiscal Year: 2010
    ..In the E18.5 LOX-null bone, the TGF-[unreadable]1 signaling was enhanced, collagen matrix was disorganized and craniofacial bone ..
  21. Bjoern Bauer; Fiscal Year: 2016
    ..The proposed research is translational because cPLA2 inhibitors are under development, and our strategy has potential to be translated into the clinic. ..
  22. Oxidative Stress, DNA Repair & Colorectal Adenoma Risk
    Michael Goodman; Fiscal Year: 2009
    ..The resulting data will be analyzed using multivariate unconditional logistic regression models. Particular attention will be paid to identification of potential gene- gene, gene-lifestyle, and gene-phenotype interactions. ..
  23. Aspirin pharmacogenetics in the Aspirin/Folate Polyp Prevention Trial
    KAREN MAKAR; Fiscal Year: 2009
    ..involved in 1) prostaglandin synthesis: COX-1, prostacyclin synthase (PGIS), and arachidonate lipoxygenase-5 (ALOX5);2) prostaglandin transport: multidrug resistance protein 4 (MRP4);and 3) aspirin metabolism: CYP2C9 and UGT1A6...
  24. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2009
    ..Results from our studies should help explicate the relation between inflammation and carcinogenesis in the human prostate, a topic of intense debate. ..
  25. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ....
  26. MOUSE MODELS TO DELINEATE A UNIQUE METABOLIC AND SKELETAL NETWORK
    CLIFFORD JAMES ROSEN; Fiscal Year: 2010
    ..genomic region that were involved in both adipocyte and osteoblast differentiation, and we showed two of these, Alox5 and Pparg, not only were suppressed in 6T marrow stromal cells (MSCs) but also carried polymorphisms which ..
  27. Therapeutic effect of boswellin in prostate cancer
    Yongkui Jing; Fiscal Year: 2005
    ..We hope our proposal will lead to the discovery of a novel complementary agent for prostate cancer treatment. ..
  28. A role for 5-lipoxyegenase in cocaine's actions
    Hari Manev; Fiscal Year: 2009
    ..We believe that with limited funding we will be in a position to verify the key components of our concept and to obtain the necessary data to initiate more complex future translational studies. ..
  29. Impact of Smoking on Lung Cancer Chemoprevention
    WAUN HONG; Fiscal Year: 2005
    ..abstract_text> ..
  30. Prostaglandin Synthesis, Genetics and Colorectal Cancer
    Cornelia M Ulrich; Fiscal Year: 2010
    ..include PTGS1 and 2, the thromboxane, prostacyclin, PGD2 and PGE2 synthases, the 5, 12- and 15- lipoxygenases (ALOX5, ALOX12 and ALOX15), PGE2 receptors, and glutathione peroxidases...
  31. Anti-cancer mechanisms of COX/LOX inhibitor licofelone on prostate carcinogenesis
    Narayanan Narayanan; Fiscal Year: 2009
    ..Considering its excellent safety profile in contrast to the conventional NSAIDs, licofelone offers great potential for preventive interventions in clinical studies for cancer chemoprevention, while minimizing toxicity. ..
  32. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2006
    ..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
  33. Aging and brain 5-lipoxygenase
    Hari Manev; Fiscal Year: 2010
    ..The proposed experiments may corroborate the hypothesis that epigenetic mechanisms are involved in brain aging. ..
  34. PHARMACOGENETICS OF ASTHMA MONOTHERAPY
    John Lima; Fiscal Year: 2005
    ..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..
  35. LEUKOTRIENE POLYMORPHISMS & MONTELUKAST RESPONSE
    John Lima; Fiscal Year: 2003
    ..This information may lead to individualization of asthma medications based on the genetic make-up of the patient. ..
  36. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2008
    ..abstract_text> ..
  37. LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS
    Jenny Mao; Fiscal Year: 2007
    ..The finding from this pilot project will provide important insight into the design and conduct of future chemopreventive trials. ..
  38. CANCER AND LEUKEMIA GROUP B
    Martin Edelman; Fiscal Year: 2002
    ..The grant will also allow for continuation of meritorious pilot protocols and will allow GCC to monitor and collect data which will produce mutual benefit to the GCC and CALGB. ..
  39. PHASE I TRIALS OF ANTICANCER AGENTS
    Martin Edelman; Fiscal Year: 2002
    ....
  40. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  41. GENES FOR ALCOHOLISM SUSCEPTIBILITY
    Tatiana Foroud; Fiscal Year: 2003
    ..These studies will result in more sophisticated genetic analyses of alcoholism related data, as well as the development of optimum sampling designs for more efficient gene identification. ..
  42. Longitudinal Studies Among At-Risk HD Gene Carriers
    Tatiana Foroud; Fiscal Year: 2006
    ..abstract_text> ..
  43. Macrophage Death in Plaque Vulnerability
    Ira Tabas; Fiscal Year: 2005
    ..New insights in this area may suggest new therapeutic strategies to combat cardiovascular disease. ..
  44. INTERACTION OF ATHEROGENIC LIPOPROTEINS WITH MACROPHAGES
    IRA A TABAS; Fiscal Year: 2010
    ..abstract_text> ..
  45. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..abstract_text> ..
  46. REACTIVE NITROGEN & CEREBRAL ISCHEMIC INJURY
    MUSH KHAN; Fiscal Year: 2003
    ....
  47. UC4 AP4 Cancer Therapy Center
    Paul Bunn; Fiscal Year: 2004
    ..Chan, PI); 2) vaccine/ DNAI/ RNA therapy (R. Garcea, PI); 3) angiogenic inhibitors/ PK/ PD modeling (S.G. Eckhardt, PI); and 4) chemoprevention agents (R. Nemenoff, PI). ..
  48. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana M Foroud; Fiscal Year: 2010
    ..2. Study the role of parkin mutations in Parkinson's disease. 3. Perform molecular studies to identify PD susceptibility genes. 4. Evaluate putative PD susceptibility genes in a case-control sample. ..
  49. New ECG Criteria for Posterior Myocardial Infarction
    Shu Fen Wung; Fiscal Year: 2004
    ..This study will aid in the detection and follow-up of patients with posterior myocardial infarction. ..
  50. GENETIC DETERMINATION OF ACUTE LUNG INJURY
    GEORGE LEIKAUF; Fiscal Year: 2004
    ..Significance: This investigation seeks to uncover novel genes not previously associated with survival during acute lung injury. Such findings could provide new biological information and insights into this severe clinical condition. ..
  51. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..
  52. ENZYMATIC ACTIVATION OF LIPOPHILIC SIGNALING MOLECULES
    Marcia Newcomer; Fiscal Year: 2004
    ..The expression of this activity as a fusion protein with lipoxygenase is predicted to facilitate the transfer of the reaction intermediate between catalytic sites. ..
  53. OPIOID WITHDRAWAL MECHANISMS IN MIDBRAIN NEURONS
    MacDonald Christie; Fiscal Year: 2002
    ..Identify key adaptations to second messenger systems underlying the changes found in Aim 5) using modulators of second messenger systems and genetically modified mice. ..
  54. FORM CELL APO (A)/LP(A) RECEPTOR--CLONING AND FUNCTION
    Ira Tabas; Fiscal Year: 2002
    ..The studies in this proposal will lead to the molecular identification of a novel cholesterol-induced receptor on foam cells and should provide important insight into the role of foam cell-apo(a)/Lp(a) interactions in atherogenesis. ..
  55. MURINE MODELS OF OCCUPATIONAL COPD
    GEORGE LEIKAUF; Fiscal Year: 2001
    ..The well-characterized mouse model generated by this proposal will be useful in the further understanding of the relationship between occupational exposures, genetic markers, inflammatory responses, and COPD. ..
  56. LINOLEIC ACID METABOLISM AND COLON CARCINOGENESIS
    Imad Shureiqi; Fiscal Year: 2005
    ..This work will set the stage for future animals and clinical studies of LA alternative pathway modulation as means of colon cancer chemoprevention. ..
  57. Conference on Cellular Biology of Atherosclerosis
    Ira Tabas; Fiscal Year: 2005
    ....
  58. PD GWAS Consortium
    Tatiana M Foroud; Fiscal Year: 2010
    ....
  59. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2009
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  60. Genetic Determinants of Nickel-induced Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2005
    ..Determination of the relative roles of the genetic loci linked to nickel sulfate exposure is likely to improve our understanding of the mechanisms involved in acute lung injury. ..
  61. A Cross-Cultural Longitudinal Assessment of FASD (U24)
    Tatiana Foroud; Fiscal Year: 2005
    ..abstract_text> ..
  62. GENETIC ANALYSIS OF HIP FRAGILITY
    Tatiana M Foroud; Fiscal Year: 2010
    ..Our goal is to find genetic causes for bone weakening conditions like osteoporosis so better treatments can be developed. ..
  63. Role of the 5-Lipoxygenase Pathway in Atherosclerosis
    Hooman Allayee; Fiscal Year: 2009
    ....
  64. Regulation of Nuclear Import/Export of 5-Lipoxygenase
    Thomas Brock; Fiscal Year: 2006
    ..This foundation can then be used to elucidate the ways these factors can change and give rise to the disease states that arise from abnormal 5-LO localization and LT synthesis. ..
  65. Molecular Targeting of 15-Lipoxygenase-1 in Colon Cancer
    Imad Shureiqi; Fiscal Year: 2007
    ..the feasibility of tumor selective targeting of 15-LOX-1 to inhibit tumorigenesis will pave the way for future preclinical and clinical development of therapeutic strategies based on molecularly targeting 15-LOX-1 ..
  66. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2008
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..
  67. Identification of Novel Biomarkers in HD
    Tatiana Foroud; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..