ALOX15

Summary

Gene Symbol: ALOX15
Description: arachidonate 15-lipoxygenase
Alias: 12-LOX, 15-LOX-1, 15LOX-1, arachidonate 15-lipoxygenase, 12/15-lipoxygenase, 15-LOX, 15-lipooxygenase-1, arachidonate 12-lipoxygenase, leukocyte-type, arachidonate omega-6 lipoxygenase
Species: human

Top Publications

  1. ncbi Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 277:16189-201. 2002
  2. ncbi Transcriptional regulation of 15-lipoxygenase expression by promoter methylation
    Cheng Liu
    Division of Hematology, Department of Medicine, Karolinska Institutet and Hospital, Stockholm, Sweden
    Exp Cell Res 297:61-7. 2004
  3. ncbi Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 74:235-45. 2006
  4. ncbi Lipoxygenase metabolism: roles in tumor progression and survival
    Graham P Pidgeon
    Department of Clinical Surgery, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Cancer Metastasis Rev 26:503-24. 2007
  5. doi 15-lipoxygenase-1 in the vasculature: expanding roles in angiogenesis
    Naoki Mochizuki
    Circ Res 102:143-5. 2008
  6. pmc Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals
    Shing Hwa Liu
    Institute of Toxicology, Taipei, Taiwan
    Br J Pharmacol 160:1963-72. 2010
  7. pmc Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments
    Jin Chu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Ann Neurol 71:57-67. 2012
  8. ncbi Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging
    U P Kelavkar
    Center for Glomerulonephritis, Renal Division, Emory University and the VAMC, Atlanta, GA 30322, USA
    Carcinogenesis 21:1777-87. 2000
  9. ncbi Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells
    Jong Sik Kim
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, MD, USA
    Mol Cancer Res 3:511-7. 2005
  10. doi Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits
    Nitin T Aggarwal
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 51:246-51. 2008

Research Grants

  1. Prostaglandin Synthesis, Genetics and Colorectal Cancer
    Cornelia M Ulrich; Fiscal Year: 2010
  2. 15-LOX-1 effects on colitis and colon cancer
    Imad Shureiqi; Fiscal Year: 2012
  3. Theodore R Holman; Fiscal Year: 2015
  4. Stavros C Manolagas; Fiscal Year: 2016
  5. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry J Smith; Fiscal Year: 2011
  6. Regulation of Neuroprotective Lipid Sgnals by Spatially Distinct NMDA Receptors
    David Stark; Fiscal Year: 2013
  7. Gene-air pollution interactions and cardiac structure and function in MESA and CH
    Victor C Van Hee; Fiscal Year: 2012
  8. AP4 Center for Studies on Hereditary Colorectal Cancer
    Bruce Boman; Fiscal Year: 2004
  9. Molecular Targeting of 15-Lipoxygenase-1 in Colon Cancer
    Imad Shureiqi; Fiscal Year: 2007
  10. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2008

Detail Information

Publications192 found, 100 shown here

  1. ncbi Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 277:16189-201. 2002
    ..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression...
  2. ncbi Transcriptional regulation of 15-lipoxygenase expression by promoter methylation
    Cheng Liu
    Division of Hematology, Department of Medicine, Karolinska Institutet and Hospital, Stockholm, Sweden
    Exp Cell Res 297:61-7. 2004
    ..Taken together, demethylation of the 15-LO promoter is a prerequisite for the gene transactivation, which contributes to tissue- and cell-type-specific regulation of 15-LO expression...
  3. ncbi Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 74:235-45. 2006
    ..The study has also reported a link between 15-LOX-2 and oestrogen receptor status in breast tumours. Both isoforms of 15-lipoxygenase have a tumour suppressing role in breast cancer...
  4. ncbi Lipoxygenase metabolism: roles in tumor progression and survival
    Graham P Pidgeon
    Department of Clinical Surgery, Trinity College Dublin, St James Hospital, Dublin 8, Ireland
    Cancer Metastasis Rev 26:503-24. 2007
    ....
  5. doi 15-lipoxygenase-1 in the vasculature: expanding roles in angiogenesis
    Naoki Mochizuki
    Circ Res 102:143-5. 2008
  6. pmc Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals
    Shing Hwa Liu
    Institute of Toxicology, Taipei, Taiwan
    Br J Pharmacol 160:1963-72. 2010
    ..Here, we investigate the role of 15-LOX-1 induction by honokiol, a small-molecular weight natural product, in PPAR-gamma and COX-2 signalling during gastric tumourigenesis...
  7. pmc Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments
    Jin Chu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Ann Neurol 71:57-67. 2012
    ..12/15-Lipoxygenase (12/15-LO) is an enzyme widely distributed in the central nervous system, and it has been involved in the neurobiology of Alzheimer disease (AD). However, the mechanism involved remains elusive...
  8. ncbi Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging
    U P Kelavkar
    Center for Glomerulonephritis, Renal Division, Emory University and the VAMC, Atlanta, GA 30322, USA
    Carcinogenesis 21:1777-87. 2000
    ..Based on these and other studies, we propose a model describing a possible role for 15-LO-1 expression in influencing the malignant potential and pathobiological behavior of adenocarcinomas...
  9. ncbi Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells
    Jong Sik Kim
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, MD, USA
    Mol Cancer Res 3:511-7. 2005
    ....
  10. doi Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits
    Nitin T Aggarwal
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 51:246-51. 2008
    ..Therefore, increased expression of 15-LO-1 increases acetylcholine relaxation in arteries and hypotensive responses in rabbits because of increased hydroxy-epoxyeicosatrienoic acid and trihydroxyeicosatrienoic acid synthesis...
  11. pmc Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis
    Nadir Chabane
    Osteoarthritis Research Unit, Research Centre of the University of Montreal Hospital Center, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 11:R44. 2009
    ....
  12. pmc 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 34:176-82. 2013
    ..These findings demonstrate that 15-LOX-1-mediated metabolism of DHA is required for it to upregulate SDC-1 and trigger the signaling pathway that elicits apoptosis in prostate cancer cells...
  13. pmc Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model
    Uddhav P Kelavkar
    Department of Urology and Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Neoplasia 8:510-22. 2006
    ..The FLiMP mouse model should also be useful in crosses with other GEM models to further define the combinations of molecular alterations necessary for PCa progression...
  14. ncbi Ku autoantigen (DNA helicase) is required for interleukins-13/-4-induction of 15-lipoxygenase-1 gene expression in human epithelial cells
    U P Kelavkar
    Center for Glomerulonephritis, Renal Division, Emory University, Atlanta, GA, USA
    Genes Immun 1:237-50. 2000
    ....
  15. ncbi The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective
    Jonas Wittwer
    Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland
    Clin Chem Lab Med 45:487-92. 2007
    Reticulocyte-type 15-lipoxygenase-1 (ALOX15) has anti-inflammatory and inflammatory effects and is implicated in the development of asthma, arthritis and atherosclerosis...
  16. ncbi Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer
    M Yuri
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Japan
    Histopathology 51:520-7. 2007
    ..The aim was to examine the switching of the two LA metabolic pathways in colonic adenomas and carcinomas...
  17. ncbi Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes
    G M Nassar
    Department of Medicine, Emory University, Atlanta, Georgia
    J Biol Chem 269:27631-4. 1994
    ..The contrasting effects of interferon-gamma and IL-13 on 15-LO induction demonstrate mechanisms by which T-lymphocyte subsets may modulate macrophage/monocyte function in inflammation or atherosclerosis...
  18. ncbi Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene
    M R Kritzik
    Institute of Biochemistry and Cell Biology, Syntex Discovery Research, Palo Alto, CA, USA
    Biochim Biophys Acta 1352:267-81. 1997
    ..7 kb transcript. In addition, we present here for the first time the cloning and sequence of the human 15-lipoxygenase gene, as well as the identification of regulatory elements in the promoter region of this gene...
  19. ncbi Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes
    U Kelavkar
    Center for Glomerulonephritis, Renal Division Emory University, and Veterans Affairs Medical Center, Atlanta, GA 30033, USA
    Mol Biol Rep 25:173-82. 1998
    ..In addition, fluorescent in situ hybridization (FISH) results refined the previous localization of 15-LO to human chromosome 17p13.3...
  20. ncbi Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes
    B Roy
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 273:32023-9. 1998
    ..This occurs as an early and essential signal transduction event for the IL-13-mediated induction of 15-LO expression. These data represent the first characterization of upstream kinases involved in the induced expression of 15-LO...
  21. ncbi 15-lipoxygenase-1 overexpression in prostate adenocarcinoma
    Uddhav Kelavkar
    Center for Glomerulonephritis, Renal Division, Emory University, VAMC, Atlanta, GA, USA
    Adv Exp Med Biol 507:133-45. 2002
  22. ncbi 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer
    Jennifer B Nixon
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Prostaglandins Leukot Essent Fatty Acids 70:7-15. 2004
    ..These data demonstrate that 13(S)-HODE induces changes in gene expression and has anti-tumorigenic effects...
  23. ncbi Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density
    Tomohiko Urano
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Miner Metab 23:226-30. 2005
    The 12/15-lipoxygenase gene Alox15 has been identified as a susceptibility gene for bone mineral density (BMD) in mice through combined genetic and genomic analyses...
  24. pmc Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer
    Martin J Heslin
    Surgical Oncology Research Laboratory, Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Ann Surg 241:941-6; discussion 946-7. 2005
    ..Also, to evaluate the expression of 15-LOX-1 in human normal mucosa, adenoma, and carcinoma with correlation to overall survival...
  25. ncbi Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1
    Jonas Wittwer
    Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland
    Hum Mutat 27:78-87. 2006
    The reticulocyte-type 15-lipoxygenase-1 (ALOX15) has antiinflammatory and inflammatory effects, and is implicated in the development of asthma, arthritis, and atherosclerosis...
  26. pmc The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11486-92. 2005
    ..Therefore, 15-LOX-1 down-regulation rather than a shift in the balance of LOXs is likely the dominant alteration in LOX metabolism which contributes to colorectal tumorigenesis by repressing apoptosis...
  27. ncbi Human ALOX12, but not ALOX15, is associated with BMD in white men and women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    J Bone Miner Res 21:556-64. 2006
    The Alox15 gene was recently identified as a negative regulator of peak BMD in mice...
  28. ncbi Orthotopic expression of human 15-lipoxygenase (LO)-1 in the dorsolateral prostate of normal wild-type C57BL/6 mouse causes PIN-like lesions
    Malabika Sen
    Department of Urology, University of Pittsburgh and Cancer Institute, PA 15232, USA
    Prostaglandins Other Lipid Mediat 81:1-13. 2006
    ..Thus, our findings demonstrate the effectiveness of this viral system for 15-LO-1 expression studies in tissues...
  29. ncbi Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity
    Erik Andersson
    Division of Hematology, Department of Medicin, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden
    Biochim Biophys Acta 1761:1498-505. 2006
    ..Taken together, this report demonstrates that human 15-LO-1 binds to PI(4.5)P(2) and PI(3.4)P(2) and that these phospholipids stimulate enzyme activity in the presence of calcium in a vesicle based assay...
  30. ncbi DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation
    U P Kelavkar
    Department of Urology, University of Pittsburgh and Cancer Institute, PA 15232, USA
    Prostaglandins Other Lipid Mediat 82:185-97. 2007
    Fifteen (15)-lipoxygenase type 1 (15-LO-1, ALOX15), a highly regulated, tissue- and cell-type-specific lipid-peroxidating enzyme has several functions ranging from physiological membrane remodeling, pathogenesis of atherosclerosis, ..
  31. ncbi A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women
    Ching Lung Cheung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China
    Hum Hered 65:1-8. 2008
    The 12/15-lipoxygenase gene ALOX15 is reported to be a negative regulator of BMD in knockout mice. Nonetheless results are controversial as over-expression of ALOX15 protects against inflammation-related bone loss...
  32. ncbi Expression of 15-lipoxygenase type-1 in human mast cells
    Magdalena Gulliksson
    The Institute of Environmental Medicine, Division of Physiology, Unit for Experimental Asthma and Allergy Research, Karolinska Institutet, P O Box 287, SE 171 77 Stockholm, Sweden
    Biochim Biophys Acta 1771:1156-65. 2007
    ..In conclusion, the expression of 15-LO-1 and release of 15-LO-1 derived products by mast cells may contribute to the role of these cells in asthma and other inflammatory diseases...
  33. pmc A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    Atherosclerosis 198:136-44. 2008
    ..We tested the hypothesis that exonic and/or promoter single nucleotide polymorphisms (SNPs) in the human 12/15-LOX gene (ALOX15) alter the risk of symptomatic coronary artery disease (CAD).
  34. ncbi 15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expression
    Helena Viita
    Department of Biotechnology and Molecular Medicine, University of Kuopio, Finland
    Circ Res 102:177-84. 2008
    ..In conclusion, the results suggest that expression of 15-LO-1 has an efficient antiangiogenic effect in vivo via reduction in growth factor mRNA levels, NO bioactivity, and VEGFR2 expression...
  35. doi Polyunsaturated fatty acid metabolizing 15-Lipoxygenase-1 (15-LO-1) expression in normal and tumorigenic human bladder tissues
    Brian J Philips
    Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA
    Appl Immunohistochem Mol Morphol 16:159-64. 2008
    ..Our finding of variable 15-LO-1 expression and enzyme activity in bladder tissues suggests a role for 15-LO-1 in bladder carcinogenesis...
  36. doi 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness
    Pamela A McCaskie
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
    Hum Genet 123:445-53. 2008
    ..We examined the role of three single nucleotide polymorphisms (SNPs) in the 15-lipoxygenase gene (ALOX15), in atherosclerosis...
  37. doi Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma
    Hans Erik Claesson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, and Orexo AB, Uppsala, Sweden
    FEBS J 275:4222-34. 2008
    ..Furthermore, the discovery of the high 15-lipoxygenase-1 activity in L1236 cells demonstrates that this cell line comprises a useful model system to study the chemical and biological roles of 15-lipoxygenase-1...
  38. doi Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes
    Hyun Yoo
    Laboratory of Dermato Immunology, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul 137 040, South Korea
    FEBS Lett 582:3249-53. 2008
    ..On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression...
  39. pmc Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells
    Xiangsheng Zuo
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 283:31341-7. 2008
    ..These findings demonstrate that histone modification in the 15-LOX-1 promoter is important to 15-LOX-1 transcriptional silencing in colon cancer cells and that HDACIs can activate gene transcription via KDM3A demethylation of H3K9me2...
  40. doi On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma
    Hans Erik Claesson
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm and Orexo AB, Uppsala, Sweden
    Prostaglandins Other Lipid Mediat 89:120-5. 2009
    ..The putative therapeutic implications of 15-LO-1 inhibitors in the treatment of asthma, chronic obstructive pulmonary disorder and Hodgkin lymphoma are discussed...
  41. pmc 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells
    X Zuo
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Oncogene 28:1496-505. 2009
    ..Thus, our results show that NuRD contributes to 15-LOX-1 transcription suppression in colon cancer cells and that HDACIs can inhibit NuRD recruitment to a promoter to activate gene transcription, as in the case of 15-LOX-1...
  42. pmc Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport
    Ginny L Weibel
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, ARC1102, Philadelphia, PA 19104 4399, USA
    Arterioscler Thromb Vasc Biol 29:837-42. 2009
    ..The purpose of this study was to determine the effect of 15-lipoxygenase-1 (15-LO-1) on cholesterol mobilization from macrophages...
  43. pmc Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes
    Uddhav P Kelavkar
    Division of Hematology Oncology and Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Neoplasia 11:692-9. 2009
    ....
  44. doi 15-Lipoxygenase-1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT-116 and HT-29
    Ismail Cimen
    Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
    Cancer Sci 100:2283-91. 2009
    ..We propose that 15-LO-1 expression in CRC might contribute to the inhibition of metastatic capacity in vitro and can be exploited for therapeutic purposes...
  45. pmc An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6
    Benjamin P Fairfax
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 19:720-30. 2010
    ..We find that variation involving two other genomic regions, CAPNS1 (encoding calpain small subunit 1) and ALOX15 (encoding arachidonate 15-lipoxygenase), show significant association with IL-6 expression...
  46. doi Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population
    Kai Zhang
    Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, Shandong, China
    Heart Vessels 25:368-73. 2010
    ..The aim of this study was to investigate the association of two polymorphisms in ALOX15 and the risk of coronary artery disease (CAD) in a Chinese Han population...
  47. pmc Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease
    Kathrin Schurmann
    Institute of Biochemistry, University Medicine Berlin Charite, D 10117 Berlin, Germany
    J Biol Chem 286:23920-7. 2011
    ..has recently been described, and this mutation leads to a near null variant of the enzyme encoded for by the ALOX15 gene...
  48. pmc 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells
    Jinming Zhao
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Asthma Institute, University of Pittsburgh Medical Center University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 108:14246-51. 2011
    ..The results confirm a previously unknown signaling role for 15LO1 and its PE-conjugated eicosanoid product in human airway epithelial cells. This pathway enhances critical inflammatory pathways integral to asthma pathogenesis...
  49. pmc Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion
    Micheline J Moussalli
    Department of Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 4:1961-72. 2011
    ..Our findings indicate that 15-LOX-1 downregulation in cancer cells is an important mechanism for terminal cell differentiation dysregulation and support the potential therapeutic utility of 15-LOX-1 reexpression to inhibit tumorigenesis...
  50. pmc 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
    Sun Il Lee
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Metastasis Rev 30:481-91. 2011
    ..Re-expression of 15-LOX-1 in colon cancer cells can function as an important therapeutic mechanism and could be further exploited to develop novel treatment approaches for this common cancer...
  51. doi Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line
    Cheng Liu
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Exp Cell Res 318:169-76. 2012
    ..These prerequisites are fulfilled in the L1236 cell line, but not in the L428 cell line...
  52. ncbi 15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma
    Helena Viita
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
    In Vivo 26:1-8. 2012
    ..Previous studies suggest either an anti- or pro-apoptotic role for 15-lipoxygenase-1 in carcinogenesis...
  53. pmc Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice
    Xiangsheng Zuo
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 104:709-16. 2012
    ....
  54. pmc Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation
    Cheng Liu
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e52703. 2012
    ..Taken together, our data suggest that regulation of histone methylation/demethylation at the 15-LOX-1 promoter is important in 15-LOX-1 expression...
  55. pmc Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase
    D J Conrad
    Cardiovascular Research Institute, University of California, San Francisco 94143 0911
    Proc Natl Acad Sci U S A 89:217-21. 1992
    ....
  56. pmc 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress
    Domenico Pratico
    Center for Experimental Therapeutics, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 164:1655-62. 2004
    ..These data show that the 12/15-LOX metabolic pathway is increased and correlates with an oxidative imbalance in the AD brain, implying that this enzyme might contribute to the pathogenesis of this neurodegenerative disorder...
  57. doi No association of two functional polymorphisms in human ALOX15 with myocardial infarction
    Martin Hersberger
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Atherosclerosis 205:192-6. 2009
    ..Screening of the human 15-lipoxygenase (ALOX15) gene detected a polymorphic C to T substitution at position c...
  58. doi Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study
    Steve Bevan
    Clinical Neuroscience, St Georges University of London, UK
    Stroke 40:696-701. 2009
    ..Using a 2-stage replication design, we have examined whether polymorphisms in 8 genes related to this pathway are associated with early atherosclerosis and remodeling as measured by carotid artery intima-media thickness...
  59. pmc Formation of a cyclopropyl epoxide via a leukotriene A synthase-related pathway in an anaerobic reaction of soybean lipoxygenase-1 with 15S-hydroperoxyeicosatetraenoic acid: evidence that oxygen access is a determinant of secondary reactions with fatty ac
    Yuxiang Zheng
    Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 285:13427-36. 2010
    ..Our results support a model in which access to molecular oxygen within the active site directs the outcome from competing pathways in the secondary reactions of lipoxygenases...
  60. doi Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators
    James F Collins
    Dept of Exercise and Nutrition Sciences, G10 Farber Hall, 3435 Main St, Univ at Buffalo, Buffalo, NY 14214, USA
    Am J Physiol Gastrointest Liver Physiol 294:G948-62. 2008
    ..homeostasis, and one gene related to this physiological process, a leukocyte type, arachidonate 12-lipoxygenase (Alox15), was selected for further examination...
  61. ncbi Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes
    Margaret K Yu
    Department of Internal Medicine, The Huntsman Cancer Institute, University of Utah Health Sciences, Salt Lake City, UT 84112 0555, USA
    J Biol Chem 279:28028-35. 2004
    ..The influences of 15-lipoxygenase-1 on (1)inflammation, cell growth, and survival may be attributable, in part, to inhibition of thioredoxin reductase and several redox-sensitive processes subordinate to thioredoxin reductase...
  62. ncbi Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene
    P Shankaranarayanan
    Eicosanoid Research Division, Department of Gynaecology, University Medical Centre Benjamin Franklin, Free University Berlin, D 12200 Berlin, Germany
    J Biol Chem 276:42753-60. 2001
    ..After 9-11 h, when histones become acetylated, STAT6 binding sites may be demasked so that the phosphorylated and acetylated transcription factor can bind to activate gene transcription...
  63. ncbi Expression of 15-lipoxygenases in pulmonary arteries after hypoxia
    Ye Liu
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, China
    Pathology 41:476-83. 2009
    ....
  64. ncbi Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancer
    Naveena B Janakiram
    Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Curr Mol Med 9:565-79. 2009
    ..In this review, we explore the mechanisms that trigger formation of LXs and Rvs, to highlight the relative importance of LXs and Rvs in carcinogenesis in relation to pro-inflammatory mediators...
  65. doi Altered epididymal sperm maturation and cytoplasmic droplet migration in subfertile male Alox15 mice
    Kelly Moore
    Division of Animal Science, Department of Obstetrics, Gynecology, University of Missouri, Columbia, MO 65211, USA
    Cell Tissue Res 340:569-81. 2010
    ..of the organelle degradation enzyme 15-lipoxygenase (15LOX) in sperm CD, we hypothesize that subfertile male Alox15 mice lacking the 15Lox gene display sperm CD anomalies...
  66. ncbi A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense
    Karsten Gronert
    New York Medical College, Department of Pharmacology, Valhalla, New York 10595, USA
    J Biol Chem 280:15267-78. 2005
    ..Here, we demonstrate that mouse corneas generate endogenous LXA(4) and NPD1. 12/15-LOX (Alox15) and LXA(4) receptor mRNA expression as well as LXA(4) formation were abrogated by epithelial removal and restored ..
  67. ncbi Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma
    Linda C Hsi
    Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, NIEHS National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 277:40549-56. 2002
    ..These results provide a plausible mechanism to explain the apparent opposing effects 15-LOX-1 and 15-LOX-2 play in prostate cancer...
  68. pmc Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence
    M V Suraneni
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX, USA
    Oncogene 29:4261-75. 2010
    ..Collectively, our results suggest that 15-LOX2 expression in mouse prostate leads to hyperplasia and also induces cell senescence, which may, in turn, function as a barrier to tumor development...
  69. ncbi Detection and subcellular localization of two 15S-lipoxygenases in human cornea
    Min S Chang
    Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 8000 MCE, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Invest Ophthalmol Vis Sci 46:849-56. 2005
    ..The presence of both 15-LOXs in the human cornea prompted this study to delineate their roles in the human corneal epithelium...
  70. pmc Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes
    Marcia McDuffie
    University of Virginia, P O Box 801405, Charlottesville, VA 22908, USA
    Diabetes 57:199-208. 2008
    ..Since the gene encoding 12/15-LO (gene designation Alox15) lies within the Idd4 diabetes susceptibility interval in NOD mice, we hypothesized that 12/15-LO is also a key ..
  71. ncbi 15(S)-HETE production in human retinal microvascular endothelial cells by hypoxia: Novel role for MEK1 in 15(S)-HETE induced angiogenesis
    Arun K Bajpai
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Invest Ophthalmol Vis Sci 48:4930-8. 2007
    ..To examine for the expression of 15-lipoxygenase 1 (15-LOX1) and 15-LOX2 in human retinal microvascular endothelial cells (HRMVECs) and study the role of arachidonic acid metabolites of these enzymes in angiogenesis...
  72. pmc 15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth
    Rene Hennig
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Neoplasia 9:917-26. 2007
    ..Thus, induction of 15-LOX-1 expression may be an attractive option for the prevention and treatment of pancreatic cancer...
  73. ncbi Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis
    Suraneni V K Mahipal
    Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India
    Biochem Pharmacol 74:202-14. 2007
    ....
  74. ncbi Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription
    Yelizaveta Torosyan
    Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University of the Health Sciences School of Medicine, Bethesda, MD 20814, USA
    Cancer Res 66:9609-16. 2006
    ..Thus, ANXA7 and p53 can distinctly regulate LOX transcription that is potentially relevant to the AA-mediated cell growth control in tumor suppression...
  75. doi Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide
    Peijuan Zhu
    Centers for Cancer Pharmacology and Excellence in Environmental Toxicology Department of Pharmacology, University of Pennsylvania School of Medicine, 854 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Rapid Commun Mass Spectrom 22:432-40. 2008
    ..This suggests that increased expression of 15(S)-HPETE modulates the activity of cellular GSH reductases or the transporters involved in removal of GSSG...
  76. pmc CREB-mediated IL-6 expression is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration
    Koteswara R Chava
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Arterioscler Thromb Vasc Biol 29:809-15. 2009
    ..The aim of the present study was to test the role of CREB in an oxidized lipid molecule, 15(S)-HETE-induced VSMC migration and neointima formation...
  77. pmc Applicability of the triad concept for the positional specificity of mammalian lipoxygenases
    Robert Vogel
    Institute of Biochemistry, University Medicine Berlin Charite, Monbijoustrasse 2, D 10117 Berlin, Germany
    J Biol Chem 285:5369-76. 2010
    ..The specificity of the platelet 12-LOX was partly explained by the triad hypothesis, but the concept was not applicable for 15-LOX2 and (12R)-LOX...
  78. pmc The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer
    Imad Shureiqi
    Department of Clinical Cancer Prevention, Unit 1360, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    FASEB J 21:743-53. 2007
    ..Maintaining 15-LOX-1 transcriptional silencing in cancer cells is a multifactorial process involving GATA-6 overexpression and other regulatory events...
  79. doi Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease
    Marcos Martínez-Clemente
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Centro de Investigaciones Biomédicas Esther Koplowitz, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Hepatology 52:1980-91. 2010
    We have shown that Alox15, the gene encoding for 12/15-lipoxygenase (12/15-LO), is markedly up-regulated in livers from apolipoprotein E-deficient (ApoE(-/-)) mice, which spontaneously develop nonalcoholic fatty liver disease secondary to ..
  80. ncbi 15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size)
    Dean G Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, 1808 Park Rd 1C, Smithville, TX 78957, United States
    Prostaglandins Other Lipid Mediat 82:135-46. 2007
    ..Here we summarize these new findings to provide a concise view of the potential biological functions of 15-LOX2 in NHP cells and of its deregulation in PCa development...
  81. ncbi Fourteen chromosomal localizations and an update of the cytogenetic map of the rabbit
    C Zijlstra
    Department of Biochemistry, Cell Biology and Histology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Cytogenet Genome Res 97:191-9. 2002
    ..The localizations comprise eleven gene loci (PRLR, GHR, HK1, ACE, TF, 18S+28S rDNA, CYP2C4, PMP2, TCRB, ALOX15 and MT1) and three microsatellite loci (Sat13, Sol33 and D1Utr6)...
  82. ncbi Regulation of bone mass in mice by the lipoxygenase gene Alox15
    Robert F Klein
    Bone and Mineral Research Unit, Department of Medicine, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Science 303:229-32. 2004
    ..Through combined genetic and genomic approaches, we identified the lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice...
  83. ncbi Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase
    Melissa K Middleton
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 176:265-74. 2006
    ..LPS-stimulated elicited peritoneal macrophages derived from 12/15-LO-deficient (Alox15) mice produced reduced IL-12 and IL-23 levels, but comparable amounts of several other inflammatory mediators ..
  84. pmc Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy
    Uddhav P Kelavkar
    Department of Urology and Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Neoplasia 8:112-24. 2006
    ..previously demonstrated an increased expression of an omega-6 LA-metabolizing enzyme, 15-lipoxygenase-1 (15-LO-1, ALOX15), in prostate tumor tissue compared with normal adjacent prostate tissue, and that elevated 15-LO-1 activity in ..
  85. pmc Selenoprotein P protects cells from lipid hydroperoxides generated by 15-LOX-1
    Colleen Rock
    Department of Pharmacology and Toxicology, University of Utah, L S Skaggs Pharmacy, Rm 201, 30 S 2000 East, Salt Lake City, UT 84112, United States
    Prostaglandins Leukot Essent Fatty Acids 83:203-10. 2010
    ..Nevertheless, this effect may help protect cells against the oxidative damage induced by these lipid metabolites...
  86. pmc Functional classes of bronchial mucosa genes that are differentially expressed in asthma
    Catherine Laprise
    Universite du Quebec a Chicoutimi, Department of Fundamental Sciences, Chicoutimi, Canada
    BMC Genomics 5:21. 2004
    ..While asthma is felt to develop as the result of interaction among many different genes and signalling pathways, only a few genes have been linked to an increased risk of developing this condition...
  87. ncbi Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene
    Ales Cvekl
    Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Eur J Cancer 40:2525-32. 2004
    ..helix-loop-helix transcription factor and member of the MYC/MAX superfamily), KIAA0399, UBE2G1 (ubiquitin ligase), ALOX15, and MINK--encode proteins with potential links to cancer...
  88. pmc Integrative predictive model of coronary artery calcification in atherosclerosis
    Michael McGeachie
    Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Circulation 120:2448-54. 2009
    ....
  89. ncbi Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3
    R Keough
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000, Australia
    Genomics 62:483-9. 1999
    ..5' region of MYBBP1A was isolated and indicates a physical linkage between MYBBP1A and the 15-lipoxygenase gene (ALOX15)...
  90. ncbi Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice
    Evgueni A Ivakine
    Program in Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Immunol 176:2976-90. 2006
    ..arachidonic acid metabolism and inflammation, phagocytosis, and lymphocyte trafficking, our combined analyses identified Alox15, Alox12e, Psmb6, Pld2, and Cxcl16 as excellent candidate genes for the effects of the Idd4 locus.
  91. pmc Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mediators Inflamm 2010:170153. 2010
    Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds.
  92. pmc Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling
    Michelle Kinder
    The Wistar Institute, Philadelphia, PA 19104, USA
    Exp Hematol 38:1036-1046.e1-4. 2010
    ..on our observation of aberrant myeloid cell representation in hematopoietic tissues of 12/15-lipoxygenase (12/15-LOX)-deficient (Alox15) mice, we tested the hypothesis that polyunsaturated fatty acid metabolism regulates myelopoiesis.
  93. pmc Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene
    U P Kelavkar
    Renal Division and Center for Glomerulonephritis, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 96:4378-83. 1999
    ..The studies define a direct link between 15-LO activity and an established tumor-suppressor gene located in close chromosomal proximity...
  94. ncbi Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxib
    Claudia P Schroeder
    Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 3:847-52. 2004
    ..Our findings provide new informations about individual eicosanoids produced by HNSCC cells and their differential regulation by the selective COX-2 inhibitor celecoxib...
  95. ncbi Conjugated linoleic acid, cis-9,trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat
    Hyejung Cho
    Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St Paul, Minnesota 55108, USA
    J Agric Food Chem 53:7262-6. 2005
    ..The authenticity of the production of 13(S)-HODE from c9,t11 as a substrate was established by isolation and cochromatography with pure standard on HPLC using non-radioactive and [14C]-c9,t11-CLA...
  96. pmc Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid
    Aaron T Wecksler
    Chemistry and Biochemistry Department, University of California, Santa Cruz, California 95064, USA
    Biochemistry 48:6259-67. 2009
    ..3 s(-1) microM(-1)). Considering that the oxygen concentration in cancerous tissue can be less than 5 microM, this result may have cellular implications with respect to the substrate specificity of 15-hLO-1...
  97. doi 12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms
    Karl Gertow
    Department of Medicine, Center for Molecular Medicine, Unit of Experimental Cardiovascular Research, Karolinska Institutet, Stockholm SE 17176, Sweden
    Atherosclerosis 215:411-6. 2011
    ..The aim of this study was to investigate mRNA expression of 12- and 15-lipoxygenases (ALOX12, ALOX12B, ALOX15, ALOX15B) and the atypical ALOXE3 in human carotid atherosclerotic lesions, in relation to cerebrovascular ..
  98. doi Genetic variants of the arachidonic acid pathway in non-steroidal anti-inflammatory drug-induced acute urticaria
    J A Cornejo-Garcia
    INSERM U 954, Nutrition Génétique et exposition aux risques environmentaux, Faculty of Medicine, University of Nancy, Vandoeuvre les Nancy, France
    Clin Exp Allergy 42:1772-81. 2012
    ....
  99. doi Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice
    Yu Liu
    Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas
    Am J Physiol Endocrinol Metab 310:E762-73. 2016
    ..Despite HFD-induced increase in expression of Alox15, a lipoxygenase that oxidizes LDL and promotes atherogenesis, global deletion of this gene failed to ameliorate ..
  100. ncbi The 15-lipoxygenase-modified high density lipoproteins 3 fail to inhibit the TNF-alpha-induced inflammatory response in human endothelial cells
    Angela Pirillo
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Immunol 181:2821-30. 2008
    ..Altogether, these results demonstrate that enzymatic modification induced by 15-LO impaired the protective role of HDL(3), generating a dysfunctional lipoprotein endowed with proinflammatory characteristics...
  101. pmc 12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia
    Robin L Haynes
    Department of Pathology, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Neurosci 35:140-54. 2013
    ..Our data support a role for 12/15-LOX activation as an inflammatory mediator of injury in PVL, with a contribution of 12/15-LOX to PVL-induced damage to or cell death of OLs, including those at the O1 and O4 stages. ..

Research Grants27

  1. Prostaglandin Synthesis, Genetics and Colorectal Cancer
    Cornelia M Ulrich; Fiscal Year: 2010
    ..and 2, the thromboxane, prostacyclin, PGD2 and PGE2 synthases, the 5, 12- and 15- lipoxygenases (ALOX5, ALOX12 and ALOX15), PGE2 receptors, and glutathione peroxidases...
  2. 15-LOX-1 effects on colitis and colon cancer
    Imad Shureiqi; Fiscal Year: 2012
    ..This improved understanding is expected to facilitate the identification of molecular targets for new strategies for colon cancer prevention. ..
  3. Theodore R Holman; Fiscal Year: 2015
    ..b>ALOX15 gene (i.e...
  4. Stavros C Manolagas; Fiscal Year: 2016
    ..Project 2 will investigate the contribution of Alox15-mediated lipid oxidation to the adverse effects of aging, hyperlipidemia, and loss of estrogens on skeletal ..
  5. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry J Smith; Fiscal Year: 2011
    ..We believe that insights gained from the proposed studies will enhance our understanding of potentially sight-threatening TAO and allow us to develop novel therapeutic approaches. ..
  6. Regulation of Neuroprotective Lipid Sgnals by Spatially Distinct NMDA Receptors
    David Stark; Fiscal Year: 2013
    ....
  7. Gene-air pollution interactions and cardiac structure and function in MESA and CH
    Victor C Van Hee; Fiscal Year: 2012
    ..conducted in MESA, several genes involved in inflammation, vascular activation, coagulation, and blood pressure (ALOX15, AGTR1, SCNN1A, and VWF) appear to modify the association between proximity to major roadways and LVM, suggesting ..
  8. AP4 Center for Studies on Hereditary Colorectal Cancer
    Bruce Boman; Fiscal Year: 2004
    ..abstract_text> ..
  9. Molecular Targeting of 15-Lipoxygenase-1 in Colon Cancer
    Imad Shureiqi; Fiscal Year: 2007
    ..the feasibility of tumor selective targeting of 15-LOX-1 to inhibit tumorigenesis will pave the way for future preclinical and clinical development of therapeutic strategies based on molecularly targeting 15-LOX-1 ..
  10. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2008
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..
  11. LINOLEIC ACID METABOLISM AND COLON CARCINOGENESIS
    Imad Shureiqi; Fiscal Year: 2005
    ..This work will set the stage for future animals and clinical studies of LA alternative pathway modulation as means of colon cancer chemoprevention. ..
  12. Prostate Cancer: A Mouse Model Testing 15-Lipoxygenase-1
    Uddhav Kelavkar; Fiscal Year: 2004
    ..abstract_text> ..
  13. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2007
    ..abstract_text> ..
  14. Intestinal Iron Transport in Iron Deficiency/Anemia
    James Collins; Fiscal Year: 2005
    ..abstract_text> ..
  15. LC-MS/MS for Biomedical Research
    William Campbell; Fiscal Year: 2004
    ..About 75-80% of instrument time will be available to these participants and the remaining time will be available to other investigators at the College. ..
  16. Nitric Oxide Regulation of Adrenal Steroidogenesis
    William Campbell; Fiscal Year: 2004
    ..4) We will determine the role of endothelial NO in regulating steroidogenesis and adrenal blood flow in the in situ perfused adrenal gland and in vivo in anesthetized rats. ..
  17. Genetics of Asthma Severity and Lung Function Decline
    Nadia Hansel; Fiscal Year: 2008
    ..Hansel new knowledge, skills and collaborative relationships necessary to successfully apply for funding as an independent investigator during the fourth year of this award. ..
  18. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..These studies will test the hypothesis that endogenous LO metabolites are important regulators of vascular tone and blood pressure in mice. ..
  19. The novel adhesion molecule Bves and corneal healing
    Min S Chang; Fiscal Year: 2010
    ..Therefore, an understanding of Bves in the human corneal epithelium has potential therapeutic benefits. ..
  20. Nucleotide Regulation of Apaf-1 Apoptosome and Apoptosis
    Dean G Tang; Fiscal Year: 2010
    ..The accomplishment of the proposed goals will greatly advance our understanding of apoptosome regulation in vivo and help us understand cellular response to environmental stress and cancer cell response to anti- tumor therapeutics. ..
  21. GENETIC ANALYSIS OF BONE STRENGTH IN MICE
    Robert Klein; Fiscal Year: 2009
    ..Discovery of the genes essential for optimal bone quality would offer tremendous insight into a poorly understood, but critically important component of overall bone strength. ..
  22. A Novel Mechanism to Regulate Caspase-8 Activation on the Mitochondrial Membrane
    DEAN TANG; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. 15-Lipoxygenase 2 is a Prostate Senescence Gene
    DEAN TANG; Fiscal Year: 2008
    ..Our long-term goal is to utilize the data obtained from this project to develop 15-LOX-2-targeted anti-PCa therapeutics that trigger cell-cycle arrest and senescence. ..
  24. PTH STIMULATED BONE FORMATION
    ROBERT JILKA; Fiscal Year: 2004
    ..abstract_text> ..
  25. EICOSANOID SYNTHESIS AND FUNCTION IN CORONARY VESSELS
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..These studies will provide specific pharmacological tools to study the role of EETs as EDHFs and provide new insights into the vascular action of the EETs. ..
  26. Role of 15S-lipoxygenase 2 in human corneal epithelium
    Min Chang; Fiscal Year: 2005
    ..From these observations, we hypothesize that 15-LOX-2 is important in maintenance of the human cornea by regulation of epithelial cellular proliferation and/or differentiation and its effects are mediated by PPARs. ..
  27. MITOCHONDRIA SIGNALED APOPTOSIS IN PROSTATE CANCER CELLS
    DEAN TANG; Fiscal Year: 2004
    ..abstract_text> ..