Gene Symbol: ALDOA
Description: aldolase, fructose-bisphosphate A
Alias: ALDA, GSD12, HEL-S-87p, fructose-bisphosphate aldolase A, aldolase A, fructose-bisphosphate, epididymis secretory sperm binding protein Li 87p, fructose-1,6-bisphosphate triosephosphate-lyase, lung cancer antigen NY-LU-1, muscle-type aldolase
Species: human
Products:     ALDOA

Top Publications

  1. Lu M, Holliday L, Zhang L, Dunn W, Gluck S. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. J Biol Chem. 2001;276:30407-13 pubmed
    ..The direct binding interaction between V-ATPase and aldolase may be a new mechanism for the regulation of the V-ATPase and may underlie the proximal tubule acidification defect in hereditary fructose intolerance. ..
  2. St Jean M, Izard T, Sygusch J. A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. J Biol Chem. 2007;282:14309-15 pubmed
    ..The data support a model whereby aldolase exists in distinct forms that regulate glycolysis or actin dynamics. ..
  3. Pfleiderer G, Thöner M, Wachsmuth E. Histological examination of the aldolase monomer composition of cells from human kidney and hypernephroid carcinoma. Beitr Pathol. 1975;156:266-79 pubmed
    ..Confirmation of these results was obtained by analysis of homogenate prepared with carefully selected tissue parts. ..
  4. Yao D, Tolan D, Murray M, Harris D, Darras B, Geva A, et al. Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr). Blood. 2004;103:2401-3 pubmed
    Aldolase (E.C., a homotetrameric protein encoded by the ALDOA gene, converts fructose-1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. Three isozymes are encoded by distinct genes...
  5. Wubbolts R, Leckie R, Veenhuizen P, Schwarzmann G, Mobius W, Hoernschemeyer J, et al. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J Biol Chem. 2003;278:10963-72 pubmed
  6. Carr D, Knull H. Aldolase-tubulin interactions: removal of tubulin C-terminals impairs interactions. Biochem Biophys Res Commun. 1993;195:289-93 pubmed
    ..These data indicate that the carboxy terminals are involved in tubulin-aldolase interactions. ..
  7. Tochio T, Tanaka H, Nakata S, Hosoya H. Fructose-1,6-bisphosphate aldolase A is involved in HaCaT cell migration by inducing lamellipodia formation. J Dermatol Sci. 2010;58:123-9 pubmed publisher
    ..Fructose-1,6-bisphosphate aldolase A (ALDOA) is a glycolytic enzyme bound to the cytoskeleton by certain growth factors, which are known to enhance ..
  8. Kishi H, Mukai T, Hirono A, Fujii H, Miwa S, Hori K. Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation. Proc Natl Acad Sci U S A. 1987;84:8623-7 pubmed
  9. Tolan D, Niclas J, Bruce B, Lebo R. Evolutionary implications of the human aldolase-A, -B, -C, and -pseudogene chromosome locations. Am J Hum Genet. 1987;41:907-24 pubmed
    ..These locations on similar chromosome pairs correctly predicted that the aldolase pseudogene arose when sequences from the aldolase-A gene were inserted into the homologous aldolase location on chromosome 10. ..

More Information

Publications148 found, 100 shown here

  1. Kusakabe T, Motoki K, Hori K. Mode of interactions of human aldolase isozymes with cytoskeletons. Arch Biochem Biophys. 1997;344:184-93 pubmed
  2. Kajita E, Moriwaki J, Yatsuki H, Hori K, Miura K, Hirai M, et al. Quantitative expression studies of aldolase A, B and C genes in developing embryos and adult tissues of Xenopus laevis. Mech Dev. 2001;102:283-7 pubmed
    ..We also show that three aldolase genes are localized on different chromosomes as single copy genes. ..
  3. Peng Y, Li X, Wu M, Yang J, Liu M, Zhang W, et al. New prognosis biomarkers identified by dynamic proteomic analysis of colorectal cancer. Mol Biosyst. 2012;8:3077-88 pubmed publisher prognostic biomarkers (78 kDa Glucose-Regulated Protein precursor (GRP78), Fructose-bisphosphate Aldolase A (ALDOA), Carbonic Anhydrase I (CA1) and Peptidyl-prolyl cis-trans isomerase A or Cyclophilin A (PPIA)) provided good ..
  4. Merkulova M, Hurtado Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello D, et al. Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution. Am J Physiol Cell Physiol. 2011;300:C1442-55 pubmed publisher
  5. Mast N, Lin J, Anderson K, Bjorkhem I, Pikuleva I. Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). PLoS ONE. 2017;12:e0187168 pubmed publisher
    ..UBE2N), cognition (STX1B and ATP1A2), cytoskeleton function (TUBA1A and YWHAZ), and energy production (ATP1A2 and ALDOA)...
  6. Panisello Roselló A, Lopez A, Folch Puy E, Carbonell T, Rolo A, Palmeira C, et al. Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update. World J Gastroenterol. 2018;24:2984-2994 pubmed publisher
    ..of ALDH2 in different organs, on therapeutic "preconditioning" strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI in organ ..
  7. Safaei A, Rezaei Tavirani M, Zamanian Azodi M, Lashay A, Mohammadi S, Ghasemi Broumand M, et al. Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis. J Lasers Med Sci. 2017;8:S20-S21 pubmed publisher
    ..b>Discussion: Centrality and cluster screening identified hub-bottelneck genes, including Aldoa, HSPD1, Pgam2, Mapk3, SLC2A4, Ctnnb1, Ywhab, HSPA8, GAPDH and Actb for DR rats versus healthy control and ENO1, ..
  8. Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, et al. Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells. PLoS ONE. 2016;11:e0163622 pubmed publisher
    ..Multiple central nodes, namely HSPA5, FN1, PDIA6, ENO1, ALDOA, JUP and KRT6A appeared to occupy regulatory nodes in the protein-protein networks upon ANXA5 modulation...
  9. Du S, Guan Z, Hao L, Song Y, Wang L, Gong L, et al. Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration. PLoS ONE. 2014;9:e85804 pubmed publisher
    Fructose-bisphosphate aldolase A (ALDOA) is a key enzyme in glycolysis and is responsible for catalyzing the reversible conversion of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate...
  10. Grigorash B, Suvorova I, Pospelov V. [AICAR-Dependent Activation of AMPK Kinase Is Not Accompanied by G1/S Block in Mouse Embryonic Stem Cells]. Mol Biol (Mosk). 2018;52:489-500 pubmed publisher
    ..An increase in the expression of glycolytic enzyme genes (LDHA, ALDOA, PCK2, GLUT4) under the effect of AICAR indicates a change in mESC metabolism towards increased glycolysis...
  11. Rivera Meza M, Vasquez D, Quintanilla M, Lagos D, Rojas B, Herrera Marschitz M, et al. Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism?. Neuropharmacology. 2018;146:175-183 pubmed publisher
    ..Recently, it was described that N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (ALDA-1) activates aldehyde dehydrogenase-2 (ALDH2), enzyme that catalyzes the oxidation of ethanol-derived acetaldehyde ..
  12. Lu Y, Tao F, Zhou M, Tang K. The signaling pathways that mediate the anti-cancer effects of caloric restriction. Pharmacol Res. 2019;141:512-520 pubmed publisher
    ..We recently found that CR also enhances ALDOA/DNA-PK/p53 signaling...
  13. Lee K, Maxwell M, Patterson M, Birckbichler P, Conway E. Identification of transglutaminase substrates in HT29 colon cancer cells: use of 5-(biotinamido)pentylamine as a transglutaminase-specific probe. Biochim Biophys Acta. 1992;1136:12-6 pubmed
    ..Amino acid sequence data identified human fructose-1,6-bisphosphate aldolase A, an intracellular protein, as a substrate for cellular transglutaminase. ..
  14. Yao X, Yang H, Zhang Y, Ren C, Nie H, Fan Y, et al. Characterization of GALNTL5 gene sequence and expression in ovine testes and sperm. Theriogenology. 2017;95:54-61 pubmed publisher
    ..Western blot analysis showed that the protein expression of PGK2, ALDOA, and GALNTL5 were significantly higher in the high motility group than in the low motility group...
  15. Perez Miller S, Younus H, Vanam R, Chen C, Mochly Rosen D, Hurley T. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat Struct Mol Biol. 2010;17:159-64 pubmed publisher
    ..We recently identified a small molecule, Alda-1, that activates wild-type ALDH2 and restores near-wild-type activity to ALDH2*2...
  16. Zhu Q, He G, Wang J, Wang Y, Chen W. Pretreatment with the ALDH2 agonist Alda-1 reduces intestinal injury induced by ischaemia and reperfusion in mice. Clin Sci (Lond). 2017;131:1123-1136 pubmed publisher
    ..The present study was set up to determine whether an ALDH2 agonist, Alda-1, could alleviate intestinal injury after gut I/R...
  17. Zhang C, Zhao L, Wu H, Tian G, Dai S, Zhao R, et al. C/D-Box Snord105b Promotes Tumorigenesis in Gastric Cancer via ALDOA/C-Myc Pathway. Cell Physiol Biochem. 2018;45:2471-2482 pubmed publisher
    ..Mechanistically, snord105b specifically bound to ALDOA and affected C-myc, which plays a key role in carcinogenesis and tumor development...
  18. Zhu W, Shen H, Zhang J, Zhang L, Zeng Y, Huang H, et al. Cytosolic proteome profiling of monocytes for male osteoporosis. Osteoporos Int. 2017;28:1035-1046 pubmed publisher
    ..Three BMD-associated proteins (ALDOA, MYH14, and Rap1B) were identified based on multiple omics evidence, and they may influence the pathogenic ..
  19. Salusjärvi L, Toivari M, Vehkomäki M, Koivistoinen O, Mojzita D, Niemelä K, et al. Production of ethylene glycol or glycolic acid from D-xylose in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2017;101:8151-8163 pubmed publisher
    ..and D-xylonate dehydratase (XylD) from Caulobacter crescentus and YagE or YjhH aldolase and aldehyde dehydrogenase AldA from Escherichia coli enabled glycolic acid production from D-xylose up to 150 mg/L...
  20. Hu Y, Yan J, Zheng M, Song X, Wang L, Shen Y, et al. Mitochondrial aldehyde dehydrogenase activity protects against lipopolysaccharide‑induced cardiac dysfunction in rats. Mol Med Rep. 2015;11:1509-15 pubmed publisher
    ..b>Alda‑1, a specific activator of ALDH2, increased the activity of ALDH2 and lessened LPS‑induced cardiac ..
  21. Morisaki T, Yashiro M, Kakehashi A, Inagaki A, Kinoshita H, Fukuoka T, et al. Comparative proteomics analysis of gastric cancer stem cells. PLoS ONE. 2014;9:e110736 pubmed publisher
    ..Based on the results of LC-MS/MS, eight proteins, including RBBP6, GLG1, VPS13A, DCTPP1, HSPA9, HSPA4, ALDOA, and KRT18, were up-regulated in both OCUM-12/SP cells and OCUM-2MD3/SP cells when compared to their corresponding ..
  22. Lazarus R, Buonora J, Jacobowitz D, Mueller G. Protein carbonylation after traumatic brain injury: cell specificity, regional susceptibility, and gender differences. Free Radic Biol Med. 2015;78:89-100 pubmed publisher
    ..Furthermore, this process is affected by gender, suggesting that hormonal mechanisms may serve a protective role against oxidative stress. ..
  23. Ahn S, Baek J, Yang S, Kim Y, Cho Y, Choi Y, et al. Long-term response to mood stabilizer treatment and its clinical correlates in patients with bipolar disorders: a retrospective observational study. Int J Bipolar Disord. 2017;5:24 pubmed publisher
    ..The long-term response to the best treatment option based on treatment algorithms was evaluated using the Alda scale. Clinical characteristics were evaluated on a lifetime basis...
  24. Youns M, ElKhoely A, Kamel R. The growth inhibitory effect of gambogic acid on pancreatic cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:551-560 pubmed publisher
    ..on pancreatic cancer cells was modulated through up-regulation of DDIT3, DUSP1, and DUSP5 and down-regulation of ALDOA, TOP2A, and ATG4B...
  25. Tangsongcharoen C, Roytrakul S, Smith D. Analysis of cellular proteome changes in response to ZIKV NS2B-NS3 protease expression. Biochim Biophys Acta Proteins Proteom. 2019;1867:89-97 pubmed publisher
    ..nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1), voltage-dependent anion-selective channel (VDAC) and aldolase A (ALDOA)) were selected for validation by independent transient expression and western blot analysis...
  26. Kim G, Jeong J, Yang H, Hur S. Differential abundance of proteome associated with intramuscular variation of meat quality in porcine longissimus thoracis et lumborum muscle. Meat Sci. 2018;149:85-95 pubmed publisher
    ..05) in the medial region. Glycolysis enzymes including enolase 3, ALDOA, LDHA, PGM1, and TPI1 were highly abundant in the medial and posterior region, whereas GAPDH and myoglobin were ..
  27. Takasaki Y, Takahashi I, Mukai T, Hori K. Human aldolase A of a hemolytic anemia patient with Asp-128----Gly substitution: characteristics of an enzyme generated in E. coli transfected with the expression plasmid pHAAD128G. J Biochem. 1990;108:153-7 pubmed
    ..These analyses demonstrated the necessity for Asp to be present at the 128th residue in order for this enzyme to be thermally stable. ..
  28. Tolan D, Schuler B, Beernink P, Jaenicke R. Thermodynamic analysis of the dissociation of the aldolase tetramer substituted at one or both of the subunit interfaces. Biol Chem. 2003;384:1463-71 pubmed
    ..The thermodynamic values describing monomer-tetramer and dimer-tetramer equilibria are analyzed with regard to possible cooperative interaction between the two subunit interfaces. ..
  29. Cabulong R, Lee W, Bañares A, Ramos K, Nisola G, Valdehuesa K, et al. Engineering Escherichia coli for glycolic acid production from D-xylose through the Dahms pathway and glyoxylate bypass. Appl Microbiol Biotechnol. 2018;102:2179-2189 pubmed publisher
    ..The results also show that overexpression of the lactaldehyde dehydrogenase gene, aldA, is needed to increase the GA production while the overexpression of glyoxylate reductase gene, ycdW, was only ..
  30. Liu B, Zhang R, Wei S, Yuan Q, Xue M, Hao P, et al. ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes. Int J Cardiol. 2018;257:150-159 pubmed publisher
    ..Adult male mice were fed with 5% ethanol or a control diet for 2months, with or without the ALDH2 activator Alda-1...
  31. Fu H, Gao H, Qi X, Zhao L, Wu D, Bai Y, et al. Aldolase A promotes proliferation and G1/S transition via the EGFR/MAPK pathway in non-small cell lung cancer. Cancer Commun (Lond). 2018;38:18 pubmed publisher
    Our previous study demonstrated that aldolase A (ALDOA) is overexpressed in clinical human lung squamous cell carcinoma and that ALDOA promotes epithelial-mesenchymal transition and tumorigenesis...
  32. Li Y, Liu S, Qi S. ALDH2 Protects Against Ischemic Stroke in Rats by Facilitating 4-HNE Clearance and AQP4 Down-Regulation. Neurochem Res. 2018;: pubmed publisher
    ..Rats were administered the ALDH2 agonist Alda-1, vehicle or the ALDH2 inhibitor cyanamide (CYA) 15 min prior to a 1...
  33. Tarnopolsky M. Myopathies Related to Glycogen Metabolism Disorders. Neurotherapeutics. 2018;15:915-927 pubmed publisher
    ..b kinase (PHKB)) and glycolysis (phosphofructokinase (PFK), phosphoglycerate mutase (PGAM2), aldolase A (ALDOA), β-enolase (ENO3)); however, 3 involve glycogen synthesis (glycogenin-1 (GYG1), glycogen synthase (GSE), and ..
  34. Ge W, Yuan M, Ceylan A, Wang X, Ren J. Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism. Biochim Biophys Acta. 2016;1862:622-634 pubmed publisher
    ..cardiac functional defect and apoptosis were reversed by the TRPV1 agonist SA13353 and the ALDH-2 agonist Alda-1 whereas the TRPV1 antagonist capsazepine nullified ALDH2/Alda-1-induced protection...
  35. Ma D, Chen X, Zhang P, Zhang H, Wei L, Hu S, et al. Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth. Oncogene. 2018;37:1041-1048 pubmed publisher
    ..DR led to upregulated aldolase A (ALDOA) expression in xenograft tumors...
  36. Zambelli V, Gross E, Chen C, Gutierrez V, Cury Y, Mochly Rosen D. Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain. Sci Transl Med. 2014;6:251ra118 pubmed publisher
    ..than their wild-type littermates, and this heightened nociception was inhibited by an ALDH2-selective activator (Alda-1). No effect on inflammation per se was observed...
  37. Costa Lima B, Suman S, Li S, Beach C, Silva T, Silveira E, et al. Dietary ractopamine influences sarcoplasmic proteome profile of pork Longissimus thoracis. Meat Sci. 2015;103:7-12 pubmed publisher
    ..These results suggest that ractopamine influences the abundance of enzymes involved in glycolytic metabolism, and the differential abundance of glycolytic enzymes could potentially influence the conversion of muscle to meat. ..
  38. Yu Y, Liao P, Guo C, Chen C, Mochly Rosen D, Chuang L. PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation. PLoS ONE. 2016;11:e0161993 pubmed publisher
    ..By contrast, an ALDH2 activator, Alda-1, significantly accelerated adipogenesis, which was accompanied by an increase in adipogenic gene expression...
  39. Mora E, Portella M, Forcada I, Vieta E, Mur M. A preliminary longitudinal study on the cognitive and functional outcome of bipolar excellent lithium responders. Compr Psychiatry. 2016;71:25-32 pubmed publisher
    ..patients were on lithium treatment during all this follow-up period and fulfilled ELR criteria as measured by the Alda scale...
  40. LI J, Ju G, Jiang J, Li N, Peng J, Luo X. Lipoic acid protects gastric mucosa from ethanol-induced injury in rat through a mechanism involving aldehyde dehydrogenase 2 activation. Alcohol. 2016;56:21-28 pubmed publisher
    ..Lipoic acid (10 or 30 mg/kg) or Alda-1 (a positive control, 10 mg/kg) was given 45 min before the ethanol treatment...
  41. Stachowicz A, Olszanecki R, Suski M, Głombik K, Basta Kaim A, Adamek D, et al. Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci. 2017;18: pubmed publisher the frontal cortex and hippocampus of apolipoprotein E knockout (apoE-/-) mice upon treatment with Alda-1-a small molecular weight activator of ALDH2...
  42. Liu W, Zhai X, Wang W, Zheng B, Zhang Z, Fan X, et al. Aldehyde dehydrogenase 2 activation ameliorates cyclophosphamide-induced acute cardiotoxicity via detoxification of toxic aldehydes and suppression of cardiac cell death. J Mol Cell Cardiol. 2018;121:134-144 pubmed publisher
    ..Importantly, ALDH2 activation by Alda-1 pretreatment markedly attenuated CY-induced accumulation of toxic aldehydes, cardiac cell death and cardiac ..
  43. Luo X, Liu B, Ma Q, Peng J. Mitochondrial aldehyde dehydrogenase, a potential drug target for protection of heart and brain from ischemia/reperfusion injury. Curr Drug Targets. 2014;15:948-55 pubmed
    ..Indeed, some of the newly identified ALDH2 activators (such as Alda-1) have demonstrated beneficial effects on heart and brain I/R injury...
  44. Mittal M, Pal S, China S, Porwal K, Dev K, Shrivastava R, et al. Pharmacological activation of aldehyde dehydrogenase 2 promotes osteoblast differentiation via bone morphogenetic protein-2 and induces bone anabolic effect. Toxicol Appl Pharmacol. 2017;316:63-73 pubmed publisher
    ..We thus studied whether activating ALDH2 by N-(1, 3-benzodioxol-5-ylmethyl)-2, 6-dichlorobenzamide (alda-1) had osteogenic effect...
  45. Stacey D, Schubert K, Clark S, Amare A, Milanesi E, Maj C, et al. A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder. Transl Psychiatry. 2018;8:183 pubmed publisher
    ..Lithium response was assessed using the well-validated ALDA scale, which we used to define both a continuous and a dichotomous measure...
  46. Stachowicz A, Olszanecki R, Suski M, Wiśniewska A, Totoń Żurańska J, Madej J, et al. Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. J Am Heart Assoc. 2014;3:e001329 pubmed publisher
    ..We investigated the influence of Alda-1, an activator of ALDH2, on atherogenesis and on the liver steatosis in apolipoprotein E knockout (apoE(-/-)) mice...
  47. Liu X, Jin G, Fan B, Xing Y, Wang L, Wang M, et al. The impact of ALDH2 activation by Alda-1 on the expression of VEGF in the hippocampus of a rat model of post-MI depression. Neurosci Lett. 2018;674:156-161 pubmed publisher
    ..Recently, it has been proposed that the activation of ALDH2 by Alda-1 can effectively reduce depressive-like behaviors and improve the prognosis of coronary heart disease...
  48. Shi S, Ji S, Qin Y, Xu J, Zhang B, Xu W, et al. Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer. Cancer Lett. 2015;360:227-33 pubmed publisher
    ..with oncogenomic alterations that reflected the abnormal expression of carbohydrate metabolic enzymes (GLUT1, ALDOA and FBP1). We also identified a linear correlation between serum tumor markers and the metabolic tumor burden...
  49. Chen C, Cruz L, Mochly Rosen D. Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo. Proc Natl Acad Sci U S A. 2015;112:3074-9 pubmed publisher
    ..We focused on ALDH3A1, which is enriched in the upper aerodigestive track, and identified Alda-89 as a small molecule that enables ALDH3A1 to metabolize acetaldehyde...
  50. Triplett J, Zhang Z, Sultana R, Cai J, Klein J, Büeler H, et al. Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease. J Neurochem. 2015;133:750-65 pubmed publisher
    ..14-3-3ε, 14-3-3 protein epsilon; 3-PGDH, phosphoglycerate dehydrogenase; ALDOA, aldolase A; APT1, acyl-protein thioesterase 1; CaM, calmodulin; CBR3, carbonyl reductase [NADPH] 3; ENO2, gamma-..
  51. Akiyama Y, Iizuka A, Kume A, Komiyama M, Urakami K, Ashizawa T, et al. Effect of STAT3 inhibition on the metabolic switch in a highly STAT3-activated lymphoma cell line. Cancer Genomics Proteomics. 2015;12:133-42 pubmed
    ..latexin as a proteomic marker candidate and metabolic enzymes including fructose-bisphosphate aldolase A (ALDOA) as a metabolic marker candidate for STAT3-targeting therapy using STAT3-specific shRNA gene transduction...
  52. Martin J, Rawls K, Chan J, Hwang S, Martínez Pastor M, McMillan L, et al. GlpR is a direct transcriptional repressor of fructose metabolic genes in Haloferax volcanii. J Bacteriol. 2018;: pubmed publisher
    ..We demonstrate that a key sugar regulatory protein in this archaeal species functions using molecular mechanisms conserved with distantly related bacterial species. ..
  53. Zhong W, Zhang W, Li Q, Xie G, Sun Q, Sun X, et al. Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. J Hepatol. 2015;62:1375-81 pubmed publisher
    Effective therapies for alcoholic liver disease are currently unavailable. The present study tested the efficacy of Alda-1, a specific aldehyde dehydrogenase 2 (ALDH2) activator, in treating alcoholic liver disease...
  54. Park S, Kwon S, Hwang J, Park D, Kim T, Kim C. Selection of appropriate reference genes for RT-qPCR analysis in Berkshire, Duroc, Landrace, and Yorkshire pigs. Gene. 2015;558:152-8 pubmed publisher
    ..In this study, we assessed the expression stability of 15 well-known candidate reference genes (ACTB, ALDOA, B2M, GAPDH, HPAR1, HSPCB, PGK1, POLR2G, PPIA, RPL4, RPS18, SDHA, TBP, TOP2B, and YWHAZ) in seven body tissues (..
  55. Thomson J, Withey J. Bicarbonate increases binding affinity of Vibrio cholerae ToxT to virulence gene promoters. J Bacteriol. 2014;196:3872-80 pubmed publisher
    ..primary virulence factors mentioned, ToxT is responsible for the activation of accessory virulence genes, such as aldA, tagA, acfA, acfD, tcpI, and tarAB...
  56. Hagiwara D, Takahashi H, Watanabe A, Takahashi Nakaguchi A, Kawamoto S, Kamei K, et al. Whole-genome comparison of Aspergillus fumigatus strains serially isolated from patients with aspergillosis. J Clin Microbiol. 2014;52:4202-9 pubmed publisher
    ..This isolate harbored five other nonsynonymous mutations, some of which were found in the afyap1 and aldA genes. We further identified a large deletion in the aspergilloma isolate in a region containing 11 genes...
  57. Chen X, Xu W, Miao M, Zhu Z, Dai J, Chen Z, et al. Alteration of sperm protein profile induced by cigarette smoking. Acta Biochim Biophys Sin (Shanghai). 2015;47:504-15 pubmed publisher
    ..Furthermore, the 2DE and MS results of five proteins (Aldoa, ATP5a1, Gpx4, Cs, and Spatc1) were validated by western blot analysis and reverse transcriptase-polymerase chain ..
  58. Wang W, Lin L, Guo J, Cheng Y, Qian J, Mehta J, et al. Heavy ethanol consumption aggravates the ischemic cerebral injury by inhibiting ALDH2. Int J Stroke. 2015;10:1261-9 pubmed publisher
    ..The activator of aldehyde dehydrogenase 2, Alda-1 abolished neuronal cells death and ischemic injury induced by ethanol and the inhibitor reversed the injurious ..
  59. Dai L, Pan G, Liu X, Huang J, Jiang Z, Zhu X, et al. High expression of ALDOA and DDX5 are associated with poor prognosis in human colorectal cancer. Cancer Manag Res. 2018;10:1799-1806 pubmed publisher
    ..Fructose-bisphosphate aldolase A (ALDOA) and DEAD box p68 RNA helicase (DDX5) are commonly overexpressed in cancer and correlate with tumorigenesis...
  60. Qattan A, Radulovic M, Crawford M, Godovac Zimmermann J. Spatial distribution of cellular function: the partitioning of proteins between mitochondria and the nucleus in MCF7 breast cancer cells. J Proteome Res. 2012;11:6080-101 pubmed publisher
    ..from the TCA-cycle (DLST, IDH2, IDH3A, OGDH, SUCLAG2, etc.), and from glycolysis (ALDOA, ENO1, FBP1, GPI, PGK1, TALDO1, etc.) were distributed to both the nucleus and mitochondria...
  61. Oliveira G, Regitano L, Cesar A, Reecy J, Degaki K, Poleti M, et al. Integrative analysis of microRNAs and mRNAs revealed regulation of composition and metabolism in Nelore cattle. BMC Genomics. 2018;19:126 pubmed publisher
    ..Candidate regulatory genes such as SDHAF4, FBXO17, ALDOA and PKM were identified by partial correlation with information theory (PCIT), phenotypic impact factor (PIF) and ..
  62. Gomes K, Bechara L, Lima V, Ribeiro M, Campos J, Dourado P, et al. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. Int J Cardiol. 2015;179:129-38 pubmed publisher
    ..Further supporting an ALDH2 mechanism, sustained Alda-1 treatment (starting 24h after permanent LAD occlusion surgery) prevented aldehydic overload, mitochondrial ..
  63. Wu B, Yu L, Wang Y, Wang H, Li C, Yin Y, et al. Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1. Oncotarget. 2016;7:2175-88 pubmed publisher
    ..Sustained Alda-1 (selective ALDH2 activator) treatment increased cardiac ALDH2 activity and abrogated these effects...
  64. Zhai X, Zhang Z, Liu W, Liu B, Zhang R, Wang W, et al. Protective effect of ALDH2 against cyclophosphamide-induced acute hepatotoxicity via attenuating oxidative stress and reactive aldehydes. Biochem Biophys Res Commun. 2018;499:93-98 pubmed publisher
    ..KO) mice were divided into four groups: WT, WT + CY, KO + CY and WT + CY + Alda-1. Biochemical analysis showed that plasma ALT was increased by 35.8% in KO + CY group and decreased by 21...
  65. Jiang Z, Wang X, Li J, Yang H, Lin X. Aldolase A as a prognostic factor and mediator of progression via inducing epithelial-mesenchymal transition in gastric cancer. J Cell Mol Med. 2018;22:4377-4386 pubmed publisher aimed to explore the clinicopathological significance and potential role of glycolytic enzyme aldolase A (ALDOA) in the carcinogenesis and progression of gastric cancer (GC)...
  66. Dalby A, Dauter Z, Littlechild J. Crystal structure of human muscle aldolase complexed with fructose 1,6-bisphosphate: mechanistic implications. Protein Sci. 1999;8:291-7 pubmed
  67. Ishida K, Matsuo J, Yamamoto Y, Yamaguchi H. Chlamydia pneumoniae effector chlamydial outer protein N sequesters fructose bisphosphate aldolase A, providing a benefit to bacterial growth. BMC Microbiol. 2014;14:330 pubmed publisher
    ..MS revealed the host protein to be fructose bisphosphate aldolase A (aldolase A), which plays a key role in glycolytic metabolism...
  68. Tighe S, Ritchey M, Schweizer B, Goes F, MacKinnon D, Mondimore F, et al. Test-retest reliability of a new questionnaire for the retrospective assessment of long-term lithium use in bipolar disorder. J Affect Disord. 2015;174:589-93 pubmed publisher
    ..the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder Scale, or the Alda Scale...
  69. Li Y, Zhang D, Kong L, Shi H, Tian X, Gao L, et al. Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling. Exp Cell Res. 2018;370:78-86 pubmed publisher
    ..Here in the present work, we identified Aldolase A (AldoA) as a core regulator of cardiac hypertrophy...
  70. Chang Y, Yang Y, Tien C, Yang C, Hsiao M. Roles of Aldolase Family Genes in Human Cancers and Diseases. Trends Endocrinol Metab. 2018;29:549-559 pubmed publisher
    The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC...
  71. Ji S, Zhang B, Liu J, Qin Y, Liang C, Shi S, et al. ALDOA functions as an oncogene in the highly metastatic pancreatic cancer. Cancer Lett. 2016;374:127-135 pubmed publisher
    ..Subsequent analysis indicated that among glycolytic genes, aldolase A (ALDOA) increased the most significantly upon TGF-β treatment...
  72. Imber M, Loi V, Reznikov S, Fritsch V, Pietrzyk Brzezinska A, Prehn J, et al. The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus. Redox Biol. 2018;15:557-568 pubmed publisher
    ..The aldehyde dehydrogenase AldA was identified as S-bacillithiolated at its active site Cys279 under NaOCl stress in S. aureus...
  73. Xia G, Fan F, Liu M, Wang S, Wu J, Shen C, et al. Aldehyde dehydrogenase 2 deficiency blunts compensatory cardiac hypertrophy through modulating Akt phosphorylation early after transverse aorta constriction in mice. Biochim Biophys Acta. 2016;1862:1587-93 pubmed publisher
    ..Cardiomyocytes were stretched for 6h in vitro in the presence or absence of Alda-1 (a small-molecule activator of ALDH2) prior to assessment of phosphorylated PI3K, Akt and total PTEN expressions ..
  74. Jin K, Li L, Sun X, Xu Q, Song S, Shen Y, et al. Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway. Appl Microbiol Biotechnol. 2017;101:4201-4213 pubmed publisher
    ..involved in glycolysis and the PPP, including hexokinase 2 (HK2), phosphofructokinase 1 (PFKM), aldolase A (ALDOA), enolase 1 (ENO1), lactate dehydrogenase A (LDHA), and glucose-6-phosphate dehydrogenase (G6PD), were also ..
  75. Dollé L. Pharmacological enrollment of aldehyde dehydrogenase modulators to assist treating ischemia reperfusion-induced intestinal injury: is there a gap to be bridged?. Clin Sci (Lond). 2017;131:1137-1140 pubmed publisher
    ..1]. In this issue of the Clinical Science, the authors evaluated the protective effect of Alda-1 (a novel class of small molecule aldehyde dehydrogenase (ALDH2) activators) in the intestinal ischemia ..
  76. Admyre C, Johansson S, Qazi K, Filén J, Lahesmaa R, Norman M, et al. Exosomes with immune modulatory features are present in human breast milk. J Immunol. 2007;179:1969-78 pubmed
    ..We conclude that human breast milk contains exosomes with the capacity to influence immune responses. ..
  77. Stachowicz A, Głombik K, Olszanecki R, Basta Kaim A, Suski M, Lasoń W, et al. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Brain Behav Immun. 2016;51:144-53 pubmed publisher
    ..We investigated the influence of Alda-1, a small-molecule activator of ALDH2, on depressive- and anxiety-like behaviors in an animal model of depression -..
  78. Nair M, Suman S, Chatli M, Li S, Joseph P, Beach C, et al. Proteome basis for intramuscular variation in color stability of beef semimembranosus. Meat Sci. 2016;113:9-16 pubmed publisher
    ..These results indicated that differential abundance of sarcoplasmic proteome contributes to intramuscular variations in beef color stability. ..
  79. Cao W, Chang T, Li X, Wang R, Wu L. Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling. Clin Sci (Lond). 2017;131:309-325 pubmed publisher
    ..significantly increased in both the aorta of fructose-fed mice and the fructose-treated VSMCs, whereas aldolase A (AldoA) expression was not changed...
  80. Moreira J, Courtin C, Geoffroy P, Curis E, Bellivier F, Marie Claire C. Lithium response in bipolar disorder: No difference in GADL1 gene expression between cell lines from excellent-responders and non-responders. Psychiatry Res. 2017;251:217-220 pubmed publisher
    ..In the present study, GADL1 gene expression was investigated in regard to lithium response, using Alda scale, in lymphoblastoid cells (LCLs) of 36 Caucasian BD patients...
  81. Weekes J, Morrison K, Mullen A, Wait R, Barton P, Dunn M. Hyperubiquitination of proteins in dilated cardiomyopathy. Proteomics. 2003;3:208-16 pubmed
    ..A number of these proteins were identified using affinity purification and matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. ..
  82. Ikeda T, Takahashi T, Tsujita M, Kanazawa M, Toriyabe M, Koyama M, et al. Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. PLoS ONE. 2015;10:e0128844 pubmed publisher
    ..We also investigated whether N-(1,3-benzodioxole-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1), a small-molecule agonist of aldehyde dehydrogenase-2, could attenuate 4-HNE levels and reduce hypoglycemic ..
  83. Alkim C, Cam Y, Trichez D, Auriol C, Spina L, Vax A, et al. Optimization of ethylene glycol production from (D)-xylose via a synthetic pathway implemented in Escherichia coli. Microb Cell Fact. 2015;14:127 pubmed publisher
    ..was optimized by deleting the genes encoding for (D)-xylulose-5 kinase (xylB) and glycolaldehyde dehydrogenase (aldA), and by overexpressing the candidate glycolaldehyde reductases YqhD, GldA, and FucO...
  84. Clarke F, Morton D. Aldolase binding to actin-containing filaments. Formation of paracrystals. Biochem J. 1976;159:797-8 pubmed
    ..The filament bundles are far more extensive and are characterized by a prominent cross-striation at 38nm intervals. It is suggested that this reflects an interaction between troponin and aldolase. ..
  85. Mamczur P, Gamian A, Kolodziej J, Dziegiel P, Rakus D. Nuclear localization of aldolase A correlates with cell proliferation. Biochim Biophys Acta. 2013;1833:2812-2822 pubmed publisher
    Muscle fructose 1,6-bisphosphate aldolase (ALDA) is a glycolytic enzyme which may localize both in nuclei and cytoplasm of cells, however its role in the nuclei is unclear...
  86. Hu N, Ren J, Zhang Y. Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α. Oncotarget. 2016;7:76398-76414 pubmed publisher
    ..05 for all), the effect of which was ablated by ALDH2. In vitro incubation of the ALDH2 activator Alda-1, the Sirt3 activator oroxylin A and the histone acetyltransferase inhibitor CPTH2 rescued insulin resistance-..
  87. Liu B, Wang J, Li M, Yuan Q, Xue M, Xu F, et al. Inhibition of ALDH2 by O-GlcNAcylation contributes to the hyperglycemic exacerbation of myocardial ischemia/reperfusion injury. Oncotarget. 2017;8:19413-19426 pubmed publisher
    ..05). Alda-1, a specific activator of ALDH2, significantly decreased ALDH2 O-GlcNAc modification and improved infarct size, ..
  88. Kumar A, Khan F, Olaniran A. Chloroacetaldehyde dehydrogenase from Ancylobacter aquaticus UV5: Cloning, expression, characterization and molecular modeling. Int J Biol Macromol. 2018;114:1117-1126 pubmed publisher
    ..In this study, a 55kDa NAD-dependent CAldA expressed by chromosomally encoded aldA gene, is reported in an indigenous Ancylobacter aquaticus UV5. A...
  89. Raghunath A, Jeyabaskar D, Sundarraj K, Panneerselvam L, Perumal E. In silico prediction of microRNAs on fluoride induced sperm toxicity in mice. Food Chem Toxicol. 2016;98:34-49 pubmed publisher
    ..miR-30e-5p, miR-17-5p, miR-122-5p and miR-541-5p) targeting six genes (Traf3, Rock2, Rgs8, Atp1b2, Cacna2d1 and Aldoa) were already validated experimentally in mice...
  90. Miousse I, Skinner C, Lin H, Ewing L, Kosanke S, Williams D, et al. Safety assessment of the dietary supplement OxyELITEâ„¢ Pro (New Formula) in inbred and outbred mouse strains. Food Chem Toxicol. 2017;109:194-209 pubmed publisher
    ..were paralleled by altered expression of gene- and microRNA-signatures of hepatotoxicity, including Cd36, Nqo1, Aldoa, Txnrd1, Scd1 and Ccng1, as well as miR-192, miR-193a and miR-125b and were most pronounced in female B6C3F1
  91. Belmont Díaz J, Yoval Sánchez B, Calleja Castañeda L, Pardo Vázquez J, Rodriguez Zavala J. Alda-1 modulates the kinetic properties of mitochondrial aldehyde dehydrogenase (ALDH2). FEBS J. 2016;283:3637-3650 pubmed publisher
    ..This proposal led to the search for activators of ALDH2 with the aim to develop cardioprotective drugs. Alda-1 was the first activator of ALDH2 identified and its cardioprotective effect has been extensively proven in vivo; ..
  92. Kawai K, Uemura M, Munakata K, Takahashi H, Haraguchi N, Nishimura J, et al. Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis. Int J Oncol. 2017;50:525-534 pubmed publisher
    ..molecular mechanisms of cancer malignancy, we investigated the expression of fructose-bisphosphate aldolase A (ALDOA) and its relationship with cancer metabolism...