ALDH1A2

Summary

Gene Symbol: ALDH1A2
Description: aldehyde dehydrogenase 1 family member A2
Alias: RALDH(II), RALDH2, RALDH2-T, retinal dehydrogenase 2, RALDH 2, retinaldehyde-specific dehydrogenase type 2
Species: human
Products:     ALDH1A2

Top Publications

  1. Deak K, Dickerson M, Linney E, Enterline D, George T, Melvin E, et al. Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. Birth Defects Res A Clin Mol Teratol. 2005;73:868-75 pubmed
    ..We chose to investigate 5 genes involved in the metabolism or synthesis of RA, ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2, for their role in the development of human neural tube defects, such as ..
  2. Amory J, Arnold S, Lardone M, Piottante A, Ebensperger M, Isoherranen N, et al. Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility. Fertil Steril. 2014;101:960-6 pubmed publisher
    ..Men with infertility had statistically significantly reduced levels of ALDH1A2 but not ALDH1A1 or ALDH1A3 in their testicular tissue compared with men with normal spermatogenesis...
  3. Wang Y, Li Y, Chen Q, Liu Z. Long-term exposure of xenoestrogens with environmental relevant concentrations disrupted spermatogenesis of zebrafish through altering sex hormone balance, stimulating germ cell proliferation, meiosis and enhancing apoptosis. Environ Pollut. 2019;244:486-494 pubmed publisher
    ..significantly up-regulated the mRNA levels of genes in mitosis (cyclinb1) and meiosis (cyp26a1 in EE2 group, aldh1a2, cyp26a1, sycp3 and spo11 in Mix)...
  4. Ariza L, Rojas A, Muñoz Chápuli R, Carmona R. The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair. PLoS Genet. 2019;15:e1007971 pubmed publisher
    ..We propose that WT1 modulates through the RALDH2/retinoic acid axis the restabilization of a part of the pancreatic stellate cell population and, indirectly, the ..
  5. Nimmagadda S, Buchtová M, Fu K, Geetha Loganathan P, Hosseini Farahabadi S, Trachtenberg A, et al. Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo. Dev Biol. 2015;407:275-88 pubmed publisher
    ..Expression of TP63, TBX22, BMP4 and FOXE1, all human clefting genes, were upregulated. In addition, ALDH1A2, ALDH1A3 and RA target, RARβ were increased while the degradation enzyme CYP26A1 was decreased...
  6. Wu S, Xue W, Huang X, Yu X, Luo M, Huang Y, et al. Distinct prognostic values of ALDH1 isoenzymes in breast cancer. Tumour Biol. 2015;36:2421-6 pubmed publisher
    ..b>ALDH1A2 and ALDH1L1 mRNA high expressions were found to be correlated to better OS for all BC patients...
  7. Stoney P, Fragoso Y, Saeed R, Ashton A, Goodman T, Simons C, et al. Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis. Brain Struct Funct. 2016;221:3315-26 pubmed publisher
    ..CYP26B1 was also investigated in the adult human brain and colocalization of CYP26A1 and the RA synthetic enzyme RALDH2 indicated a different, autocrine role for RA in human hippocampal neurons...
  8. Wang X, Zhou L, Jin J, Yang Y, Song G, Shen Y, et al. Knockdown of FABP3 impairs cardiac development in Zebrafish through the retinoic acid signaling pathway. Int J Mol Sci. 2013;14:13826-41 pubmed publisher
    ..On the other hand, the expression level of the RA synthesizing enzyme Raldh2 did not significantly change in FABP3-MO injected zebrafish...
  9. Endo T, Freinkman E, de Rooij D, Page D. Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis. Proc Natl Acad Sci U S A. 2017;114:E10132-E10141 pubmed publisher
    ..We found that pachytene spermatocytes, which express an RA-synthesizing enzyme, Aldh1a2, contribute directly and significantly to RA production in testes...

More Information

Publications142 found, 100 shown here

  1. Mijiddorj T, Kanasaki H, Sukhbaatar U, Oride A, Ishihara T, Kyo S. Retinoic acid and retinaldehyde dehydrogenase are not involved in the specific induction of the follicle-stimulating hormone β subunit by trichostatin A, a selective inhibitor of histone deacetylase. Gen Comp Endocrinol. 2017;242:59-65 pubmed publisher
    ..prevents histone acetylation, significantly inhibited TSA-induced FSHβ mRNA expression as well as TSA-induced RALDH2 and RALDH3 mRNA expression...
  2. Palles C, Chegwidden L, Li X, Findlay J, Farnham G, Castro Giner F, et al. Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus. Gastroenterology. 2015;148:367-78 pubmed publisher
    ..of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87-0.93; P = 3.72 × 10(-9))...
  3. Carmona R, Cañete A, Cano E, Ariza L, Rojas A, Muñoz Chápuli R. Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice. elife. 2016;5: pubmed publisher
    ..This process fails when Wt1 is deleted from this area. Mutant embryos show Raldh2 downregulation in the lateral mesoderm, but not in the intermediate mesoderm...
  4. Buchman C, Mahalingan K, Hurley T. Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors. Chem Biol Interact. 2015;234:38-44 pubmed publisher
    ..Single concentration measurements at 10μM compound were performed using ALDH1A1, ALDH1A2, ALDH1A3, ALDH2, ALDH1B1, ALDH3A1, ALDH4A1, and/or ALDH5A1 to determine the selectivity of these 12 compounds ..
  5. Morales R, Campos Mora M, Gajardo T, Pérez F, Campos J, Aguillón J, et al. Retinaldehyde dehydrogenase activity is triggered during allograft rejection and it drives Th1/Th17 cytokine production. Immunobiology. 2015;220:769-74 pubmed publisher
    ..In addition, we found that the expression of the mRNA coding for the isoform RALDH2 is up-regulated on graft rejecting draining lymph nodes (dLNs) cells...
  6. Goncalves M, Wu Y, Clarke E, Grist J, Hobbs C, Trigo D, et al. Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells. J Neurosci. 2019;39:3013-3027 pubmed publisher
    ..in a Phase 1 trial, ISRCTN12424734) leads to the endogenous synthesis of RA through retinaldehyde dehydrogenase 2 (Raldh2) in NG2 cells and controls exosome-associated-RA intracellular levels through a decorin-Ca2+ pathway...
  7. Narumanchi S, Kalervo K, Perttunen S, Wang H, Immonen K, Kosonen R, et al. Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish. J Cardiovasc Dev Dis. 2019;6: pubmed publisher
    ..nuclear antigen (PCNA) positive cardiomyocytes at 7 dpi and increased the expression of the epicardial marker raldh2 at 7 dpi...
  8. Khare A, Chakraborty K, Raundhal M, Ray P, Ray A. Cutting Edge: Dual Function of PPARγ in CD11c+ Cells Ensures Immune Tolerance in the Airways. J Immunol. 2015;195:431-5 pubmed publisher
    ..First, PPARγ was crucial for the induction of retinaldehyde dehydrogenase (aldh1a2) selectively in CD103(+) dendritic cells, which we recently showed promotes Foxp3 expression in naive CD4(+) T ..
  9. Seritrakul P, Samarut E, Lama T, Gibert Y, Laudet V, Jackman W. Retinoic acid expands the evolutionarily reduced dentition of zebrafish. FASEB J. 2012;26:5014-24 pubmed publisher
    ..dentition of fish species that retain anterior pharyngeal teeth such as medaka but that medaka do not express the aldh1a2 RA-synthesizing enzyme in tooth-forming regions...
  10. Gabbasov R, Xiao F, Howe C, Bickel L, O Brien S, Benrubi D, et al. NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice. Oncogene. 2018;37:4854-4870 pubmed publisher
    ..exhibited more mesenchymal "stem-like" transcriptional program, including increased expression of Aldh1a1 and Aldh1a2. Conversely, loss of Nedd9 resulted in increased expression of differentiation genes, including fallopian tube ..
  11. House C, Jordan E, Hernandez L, Ozaki M, James J, Kim M, et al. NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells. Cancer Res. 2017;77:6927-6940 pubmed publisher
    ..RelB also affected expression of the ALDH gene ALDH1A2 Interestingly, classical NFκB signaling through the RelA transcription factor was equally important for ..
  12. Cunningham T, Colas A, Duester G. Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors. Biol Open. 2016;5:1821-1833 pubmed publisher
    ..Importantly, validation of top-ranked genes in vivo using RA-deficient Raldh2-/- embryos identified novel examples of RA activation (Nkx1-2, Zfp503, Zfp703, Gbx2, Fgf15, Nt5e) or RA ..
  13. Witty A, Mihic A, Tam R, Fisher S, Mikryukov A, Shoichet M, et al. Generation of the epicardial lineage from human pluripotent stem cells. Nat Biotechnol. 2014;32:1026-35 pubmed publisher
    ..the epicardial lineage, including the transcription factors WT1 and TBX18 and the retinoic acid-producing enzyme ALDH1A2. When induced to undergo epithelial-to-mesenchymal transition, the cells give rise to populations that display ..
  14. Lee B, Wu C, Lin Y, Park S, Wei L. Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling. Nucleic Acids Res. 2016;44:7568-79 pubmed publisher
    ..This involves feed forward regulation of Raldh2, a rate-limiting enzyme for RA biosynthesis, and requires Med25 to coordinate RAR, STAT6 and chromatin remodeler, ..
  15. Kukreja S, Gautam P, Saxena R, Saxena M, Udaykumar N, Kumar A, et al. Identification of novel candidate regulators of retinotectal map formation through transcriptional profiling of the chick optic tectum. J Comp Neurol. 2017;525:459-477 pubmed publisher
    ..Two such genes, encoding Wnt5a and Raldh2, the synthesizing enzymes for retinoic acid, were further analyzed for their function as putative regulators of ..
  16. D Aniello E, Ravisankar P, Waxman J. Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis. PLoS ONE. 2015;10:e0138588 pubmed publisher
    ..mild RA deficient phenotypes, Rdh10a can sensitize embryos to RA deficiency and enhance phenotypes observed when Aldh1a2 function is perturbed...
  17. Pezoldt J, Pasztoi M, Zou M, Wiechers C, Beckstette M, Thierry G, et al. Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes. Nat Commun. 2018;9:3903 pubmed publisher
    ..LNs further refine their location-specific immunomodulatory functions, such as subset-specific expression of Aldh1a2/3...
  18. Wu W, Sun M, Chen F, Cao A, Liu H, Zhao Y, et al. Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43. Mucosal Immunol. 2017;10:946-956 pubmed publisher
    ..Mechanistically, acetate-induced DC expression of Aldh1a2, which converts Vitamin A into its metabolite retinoic acid (RA)...
  19. Ting D, Wittner B, Ligorio M, Vincent Jordan N, Shah A, Miyamoto D, et al. Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell Rep. 2014;8:1905-1918 pubmed publisher
    ..and tumor-derived cell lines, showing low-proliferative signatures, enrichment for the stem-cell-associated gene Aldh1a2, biphenotypic expression of epithelial and mesenchymal markers, and expression of Igfbp5, a gene transcript ..
  20. Perisé Barrios A, Gómez R, Corbí A, de la Mata J, Domínguez Soto A, Muñoz Fernandez M. Use of carbosilane dendrimer to switch macrophage polarization for the acquisition of antitumor functions. Nanoscale. 2015;7:3857-66 pubmed publisher
    ..gene expression profile towards the acquisition of M1 polarization markers (INHBA, SERPINE1, FLT1, EGLN3 and ALDH1A2) and the loss of M2 polarization-associated markers (EMR1, IGF1, FOLR2 and SLC40A1)...
  21. Nakao T, Iwata T, Hotchi M, Yoshikawa K, Higashijima J, Nishi M, et al. Prediction of response to preoperative chemoradiotherapy and establishment of individualized therapy in advanced rectal cancer. Oncol Rep. 2015;34:1961-7 pubmed publisher
    ..TBX18 upregulation was common to both groups whereas BTNL8, LOC375010, ADH1B, HRASLS2, LOC284232, GCNT3 and ALDH1A2 were significantly differentially lower in both groups when compared with the non-responders...
  22. Siegenthaler J, Ashique A, Zarbalis K, Patterson K, Hecht J, KANE M, et al. Retinoic acid from the meninges regulates cortical neuron generation. Cell. 2009;139:597-609 pubmed publisher
    ..In addition, Rdh10- and Raldh2-expressing cells in the dorsal meninges were either reduced or absent in the Foxc1 mutants, and Rdh10 mutants had ..
  23. Lee J, Protze S, Laksman Z, Backx P, Keller G. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell. 2017;21:179-194.e4 pubmed publisher
    ..and atrial cardiomyocytes derive from different mesoderm populations that can be distinguished based on CD235a and RALDH2 expression, respectively...
  24. Nim H, Furtado M, Costa M, Rosenthal N, Kitano H, Boyd S. VISIONET: intuitive visualisation of overlapping transcription factor networks, with applications in cardiogenic gene discovery. BMC Bioinformatics. 2015;16:141 pubmed publisher
    ..Applying VISIONET to the Tbx20-Gata4 transcription factor network led to the discovery and validation of Aldh1a2, an essential developmental gene associated with various important cardiac disorders, as a healthy adult cardiac ..
  25. Jimenez R, Pequerul R, Amor A, Lorenzo J, Metwally K, Aviles F, et al. Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells. Chem Biol Interact. 2019;306:123-130 pubmed publisher
    ..described as aldo-keto reductase inhibitors) were tested as inhibitors of the ALDH1A enzymes (namely, ALDH1A1, ALDH1A2 and ALDH1A3) as a first step to develop some potential drugs for cancer therapy...
  26. Shimizu T, Bae Y, Hibi M. Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Development. 2006;133:4709-19 pubmed
    ..Our results indicate that the Cdx-Hox code modifies tissue competence to respond to Fgfs and RA in neural tissue. ..
  27. Laffont S, Siddiqui K, Powrie F. Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells. Eur J Immunol. 2010;40:1877-83 pubmed publisher
    ..dampens the tolerogenic properties of MLN CD103(+) DC, which is associated with lower expression of tgfbeta2 and aldh1a2. Accordingly, CD103(+) DC taken from colitic mice are impaired in their ability to induce Foxp3(+) Treg and ..
  28. Nakamura J, Sato Y, Kitai Y, Wajima S, Yamamoto S, Oguchi A, et al. Myofibroblasts acquire retinoic acid-producing ability during fibroblast-to-myofibroblast transition following kidney injury. Kidney Int. 2019;95:526-539 pubmed publisher
    ..Healthy proximal tubules expressed retinaldehyde dehydrogenase 2 (RALDH2), a rate-limiting enzyme in retinoic acid biosynthesis...
  29. Maynard T, Gopalakrishna D, Meechan D, Paronett E, Newbern J, LaMantia A. 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013;22:300-12 pubmed publisher
    ..Similarly, RA exposure or genetic loss of RA function via heterozygous mutation of the RA synthetic enzyme Raldh2 induces novel cranial anomalies and enhances cardiovascular phenotypes in LgDel but not other genotypes...
  30. Flahaut M, Jauquier N, Chevalier N, Nardou K, Balmas Bourloud K, Joseph J, et al. Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma. BMC Cancer. 2016;16:781 pubmed
    ..The subfamily of aldehyde dehydrogenases 1 (ALDH1) isoenzymes, which comprises ALDH1A1, ALDH1A2, and ALDH1A3, is involved in the synthesis of retinoic acid, and has been identified as functional stem cell ..
  31. Ueda S, Cordeiro I, Moriyama Y, Nishimori C, Kai K, Yu R, et al. Cux2 refines the forelimb field by controlling expression of Raldh2 and Hox genes. Biol Open. 2019;8: pubmed publisher
    ..functional analyses revealed that expression of Hoxb genes and retinaldehyde dehydrogenase 2 (Raldh2), which are involved in limb positioning, are directly activated by Cux2 in the lateral plate mesoderm...
  32. Harper A, Le A, Mather T, Burgett A, Berry W, Summers J. Design, synthesis, and ex vivo evaluation of a selective inhibitor for retinaldehyde dehydrogenase enzymes. Bioorg Med Chem. 2018;26:5766-5779 pubmed publisher
    The retinaldehyde dehydrogenase (RALDH) enzymes, RALDH1, RALDH2, and RALDH3, catalyze the irreversible oxidation of retinaldehyde to all-trans-retinoic acid (ATRA)...
  33. Feng R, Fang L, Cheng Y, He X, Jiang W, Dong R, et al. Retinoic acid homeostasis through aldh1a2 and cyp26a1 mediates meiotic entry in Nile tilapia (Oreochromis niloticus). Sci Rep. 2015;5:10131 pubmed publisher
    ..In this study, the genes encoding RA synthase aldh1a2, and catabolic enzyme cyp26a1 were isolated from Nile tilapia (Oreochromis niloticus), a species without stra8...
  34. Samson C, Jurickova I, Molden E, Schreiner W, Colliver J, Bonkowski E, et al. Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice. Inflamm Bowel Dis. 2011;17:2443-55 pubmed publisher
    ..b>RALDH2-expressing dendritic cells (DC) and IL-4 promote CCR9 imprinting and small bowel homing of T lymphocytes, in ..
  35. Chen Q, Yokoi H, Suzuki T. Expression profiles of RA synthases and catabolic enzymes in newly hatched and metamorphosing larvae of Japanese flounder, Paralichthys olivaceus. Gen Comp Endocrinol. 2018;269:60-67 pubmed publisher
    ..of RA in flounder metamorphic development, we here examined the tissue mRNA expression of RA synthases (aldh1a1, aldh1a2, aldh1a3) and catabolic enzymes (cyp26a1, cyp26b1, cyp26c1) in newly hatched and metamorphosing larvae, and three-..
  36. Nakajima T, Iguchi T, Sato T. Retinoic acid signaling determines the fate of uterine stroma in the mouse Müllerian duct. Proc Natl Acad Sci U S A. 2016;113:14354-14359 pubmed
    ..Retinol dehydrogenase 10 (RDH10) and aldehyde dehydrogenase family 1 subfamily A2 (ALDH1A2) mRNAs and proteins and transactivation activity of endogenous RA were found in the stroma of proximal Mü..
  37. Moazzen H, Lu X, Liu M, Feng Q. Pregestational diabetes induces fetal coronary artery malformation via reactive oxygen species signaling. Diabetes. 2015;64:1431-43 pubmed publisher
    ..factor 1α (Hif-1α), Snail1, Slug, basic fibroblast growth factor (bFgf), and retinaldehyde dehydrogenase (Aldh1a2) was decreased and E-cadherin expression was increased in the hearts of fetuses of diabetic mothers...
  38. Manoharan I, Hong Y, Suryawanshi A, Angus Hill M, Sun Z, Mellor A, et al. TLR2-dependent activation of β-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation. J Immunol. 2014;193:4203-13 pubmed publisher
    ..to induce regulatory molecules IL-10 (Il-10) and vitamin A metabolizing enzyme retinaldehyde dehydrogenase 2 (Aldh1a2) and to suppress proinflammatory cytokines...
  39. Szatmari I, Pap A, Rühl R, Ma J, Illarionov P, Besra G, et al. PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006;203:2351-62 pubmed
    ..retinol and retinal metabolizing enzymes such as retinol dehydrogenase 10 and retinaldehyde dehydrogenase type 2 (RALDH2)...
  40. Janesick A, Tang W, Shioda T, Blumberg B. RARγ is required for mesodermal gene expression prior to gastrulation in Xenopus. Development. 2018;145: pubmed publisher
    ..Despite overlapping expression patterns of the genes encoding the RA-synthesizing enzyme Aldh1a2 and the RA-degrading enzyme Cyp26a1, RARγ1 functions as a transcriptional activator in early mesoderm ..
  41. Li J, Yue Y, Dong X, Jia W, Li K, Liang D, et al. Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly. J Biol Chem. 2015;290:10216-28 pubmed publisher
    ..somites of foxc1a knock-out embryos, expressions of fgf8a and deltaC were abolished, whereas the expression of aldh1a2 (responsible for providing retinoic acid signaling) was significantly increased...
  42. Mason M, Hockman D, Curry L, Cunningham T, Duester G, Logan M, et al. Retinoic acid-independent expression of Meis2 during autopod patterning in the developing bat and mouse limb. Evodevo. 2015;6:6 pubmed publisher
    ..Additionally, genes encoding RA-synthesising enzymes, Rdh10 and Aldh1a2, and the RA nuclear receptor Rarβ are robustly expressed in bat fore- and hindlimb interdigital tissues ..
  43. Li J, Yue Y, Zhao Q. Retinoic Acid Signaling Is Essential for Valvulogenesis by Affecting Endocardial Cushions Formation in Zebrafish Embryos. Zebrafish. 2016;13:9-18 pubmed publisher
    ..Herein, we investigated the role of RA signaling in cardiac valve development by knocking down aldh1a2, the gene encoding an enzyme that is mainly responsible for RA synthesis during early development, in zebrafish ..
  44. Fioruci Fontanelli B, Chuffa L, Mendes L, Pinheiro P, Justulin L, Felisbino S, et al. Ethanol modulates the synthesis and catabolism of retinoic acid in the rat prostate. Reprod Toxicol. 2015;53:1-9 pubmed publisher
    ..Aldehyde dehydrogenase (ALDH) subtype 1A3 was increased in the dorsal prostate of UChA animals while ALDH1A1 and ALDH1A2 decreased in the lateral prostate...
  45. Hou J, Wei W, Saund R, Xiang P, Cunningham T, Yi Y, et al. A regulatory network controls nephrocan expression and midgut patterning. Development. 2014;141:3772-81 pubmed publisher
    ..We observed that Nepn expression is dramatically reduced in Sox17(-/-) and Raldh2(-/-) embryos compared with wild-type embryos...
  46. Dash S, Narumanchi S, Paavola J, Perttunen S, Wang H, Lakkisto P, et al. Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish. Am J Physiol Heart Circ Physiol. 2017;312:H1085-H1095 pubmed publisher
    ..We further found that sept7b and retinoic acid signaling pathways converge to regulate cardiac function. These data prompt further studies defining the role of sept7b in cardiomyopathies. ..
  47. Metzler M, Raja S, Elliott K, Friedl R, Tran N, Brugmann S, et al. RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018;145: pubmed publisher
    ..at the site of gland initiation is colocalized with expression of retinol metabolic genes Rdh10 and Aldh1a2 in the underlying SMG mesenchyme...
  48. Morgan C, Parajuli B, Buchman C, Dria K, Hurley T. N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. Chem Biol Interact. 2015;234:18-28 pubmed publisher
    ..We sought to determine the selectivity of DEAB toward ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH1L1, ALDH2, ALDH3A1, ALDH4A1 and ALDH5A1 isoenzymes and determine the mechanism by which ..
  49. Magvanjav O, Gong Y, McDonough C, Chapman A, Turner S, Gums J, et al. Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/?-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials. J Am Heart Assoc. 2017;6: pubmed publisher
    ..We discovered a single nucleotide polymorphism, the rs261316 major allele, at chromosome 15 in the gene ALDH1A2 associated with an increased odds of having uncontrolled BP on combination therapy (odds ratio: 2...
  50. Jones L, Cook P, Ivens A, Thomas G, Phythian Adams A, Allen J, et al. Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid. Int Immunol. 2015;27:589-96 pubmed publisher
    ..IL-4 has also been shown to induce Aldh1a2 (aldehyde dehydrogenase 1a2) expression in murine macrophages recruited to the peritoneal cavity...
  51. Mizee M, Nijland P, van der Pol S, Drexhage J, Van het Hof B, Mebius R, et al. Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis. Acta Neuropathol. 2014;128:691-703 pubmed publisher
    ..Immunohistochemical analysis revealed that retinaldehyde dehydrogenase 2 (RALDH2), a key enzyme for RA synthesis, is highly expressed by reactive astrocytes throughout white matter lesions ..
  52. Kim H, Jung M, Choi S, Moon W, Kim S. Different Biological Action of Oleic Acid in ALDHhigh and ALDHlow Subpopulations Separated from Ductal Carcinoma In Situ of Breast Cancer. PLoS ONE. 2016;11:e0160835 pubmed publisher
    ..COM cells. OA led to an increase in the expression of ALDH1A1, ALDH1A2 and ALDH1A3 in MCF10DCIS.COM cells...
  53. Gundra U, Girgis N, Rückerl D, Jenkins S, Ward L, Kurtz Z, et al. Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct. Blood. 2014;123:e110-22 pubmed publisher
    ..and tissue-derived AAMs expressed high levels of Arg1, Chi3l3, and Retnla, only monocyte-derived AAMs up-regulated Raldh2 and PD-L2...
  54. Pradhan A, Olsson P. Inhibition of retinoic acid synthesis disrupts spermatogenesis and fecundity in zebrafish. Gen Comp Endocrinol. 2015;217-218:81-91 pubmed publisher
    ..Internal coordinate mechanics docking software showed that WIN 18,446 can bind to the rat, human and zebrafish Aldh1a2 catalytic domain with equivalent potency...
  55. Liang H, Wu C, Deng Y, Zhu L, Zhang J, Gan W, et al. Aldehyde Dehydrogenases 1A2 Expression and Distribution are Potentially Associated with Neuron Death in Spinal Cord of Tg(SOD1*G93A)1Gur Mice. Int J Biol Sci. 2017;13:574-587 pubmed publisher
    ..Aldehyde dehydrogenases 1A2 (ALDH1A2) was thought to be one of potential candidates...
  56. Holmes R. Comparative and evolutionary studies of vertebrate ALDH1A-like genes and proteins. Chem Biol Interact. 2015;234:4-11 pubmed publisher
    ..Bioinformatic analyses of vertebrate and invertebrate genomes were undertaken using known ALDH1A1, ALDH1A2 and ALDH1A3 amino acid sequences...
  57. Arnold S, Kent T, Hogarth C, Schlatt S, Prasad B, Haenisch M, et al. Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations. J Lipid Res. 2015;56:342-57 pubmed publisher
    ..While ALDH1A1, ALDH1A2, and ALDH1A3 all form RA, the expression pattern and relative contribution of these enzymes to RA formation in ..
  58. Xi J, Yue J, Yang Z. Expression profiles of retinoic acid synthetases ALDH1As and metabolic enzymes CYP26s in adult and embryonic zebrafish (Danio rerio). Genet Mol Res. 2015;14:3948-56 pubmed publisher
    ..b>ALDH1A2 exhibited an earlier and sharper expression peak [12 hours post-fertilization (hpf)] than ALDH1A3 (24 hpf)...
  59. Gurav A, Sivaprakasam S, Bhutia Y, Boettger T, Singh N, Ganapathy V. Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. Biochem J. 2015;469:267-78 pubmed publisher
    ..express the immunosuppressive enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and aldehyde dehydrogenase 1A2 (Aldh1A2), promote conversion of naive T-cells into immunosuppressive forkhead box P3(+) (FoxP3(+)) Tregs (regulatory T-..
  60. Berenguer M, Lancman J, Cunningham T, Dong P, Duester G. Mouse but not zebrafish requires retinoic acid for control of neuromesodermal progenitors and body axis extension. Dev Biol. 2018;441:127-131 pubmed publisher
    ..In zebrafish, a role for RA in body axis extension was not supported by previous studies on aldh1a2 (raldh2) mutants lacking RA synthesis...
  61. Patel N, Rhinn M, Semprich C, Halley P, Dolle P, Bickmore W, et al. FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription. PLoS Genet. 2013;9:e1003614 pubmed publisher
    ..Using the Raldh2 mutant as a model for retinoid deficiency, we further find that such changes in higher order chromatin ..
  62. Arnold S, Kent T, Hogarth C, Griswold M, Amory J, Isoherranen N. Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner. Biochem Pharmacol. 2015;95:177-92 pubmed publisher
    ..ALDH1A1 and ALDH1A2 were responsible for the majority of atRA formation in the testis while ALDH1A1 and aldehyde oxidase contributed ..
  63. Hou F, Xiao M, Li J, Cook D, Zeng W, Zhang C, et al. Ameliorative Effect of Grape Seed Proanthocyanidin Extract on Cadmium-Induced Meiosis Inhibition During Oogenesis in Chicken Embryos. Anat Rec (Hoboken). 2016;299:450-60 pubmed publisher
    ..in the mRNA expressions of various meiosis-specific markers (Stra8, Spo11, Scp3, and Dmc1) together with those of Raldh2, a retinoic acid (RA) synthetase, and of the receptors (RARα and RARβ)...
  64. Brunskill E, Potter S. Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis. BMC Nephrol. 2015;16:71 pubmed publisher
    ..They also showed upregulation of protective genes, including Aldh1a2, involved in retinoic acid synthesis and Decorin, a Tgfb antagonist...
  65. Kent T, Arnold S, Fasnacht R, Rowsey R, Mitchell D, Hogarth C, et al. ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes. Biol Reprod. 2016;94:12 pubmed publisher
    ..Here, we show via various quantitative methods that the three well-known ALDH enzymes (ALDH1A1, ALDH1A2, and ALDH1A3), and an ALDH enzyme previously unreported in the murine testis (ALDH8A1), are not expressed in a ..
  66. Kelly K, MacPherson A, Grewal H, Strnad F, Jones J, Yu J, et al. Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke. BMC Neurosci. 2016;17:49 pubmed publisher
    ..markers as meningeal fibroblasts, including expression of the retinoic acid (RA) synthesis proteins Raldh1 and Raldh2. Using a focal brain ischemia injury model to induce PSC activation and expansion, we show a substantial increase ..
  67. Pillay L, Mackowetzky K, Widen S, Waskiewicz A. Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation. PLoS ONE. 2016;11:e0166040 pubmed publisher
    ..for HSC gene expression prior to dorsal aorta formation, at a time when the predominant RA synthesis enzyme, aldh1a2, is strongly expressed within the paraxial mesoderm and somites...
  68. Offen N, Kang J, Meyer A, Begemann G. Retinoic acid is involved in the metamorphosis of the anal fin into an intromittent organ, the gonopodium, in the green swordtail (Xiphophorus hellerii). PLoS ONE. 2013;8:e77580 pubmed publisher
    ..We showed that aldh1a2, a RA synthesizing enzyme, and the RA receptors, rar-ga and rar-gb, are expressed in anal fins during ..
  69. El Robrini N, Etchevers H, Ryckebüsch L, Faure E, Eudes N, Niederreither K, et al. Cardiac outflow morphogenesis depends on effects of retinoic acid signaling on multiple cell lineages. Dev Dyn. 2016;245:388-401 pubmed publisher
    ..to rescue the early lethality resulting from inactivation of the murine retinaldehyde dehydrogenase 2 (Raldh2) gene. By embryonic day 13...
  70. Li M, Feng R, Ma H, Dong R, Liu Z, Jiang W, et al. Retinoic acid triggers meiosis initiation via stra8-dependent pathway in Southern catfish, Silurus meridionalis. Gen Comp Endocrinol. 2016;232:191-8 pubmed publisher
    ..pathway in RA mediated meiotic initiation in fishes, in the present study, the genes encoding RA synthase aldh1a2 and catabolic enzyme cyp26a1 and cyp26b1 were cloned from the Southern catfish...
  71. Boglino A, Ponce M, Cousin X, Gisbert E, Manchado M. Transcriptional regulation of genes involved in retinoic acid metabolism in Senegalese sole larvae. Comp Biochem Physiol B Biochem Mol Biol. 2017;203:35-46 pubmed publisher
    ..development and only six related with DEAB treatments directly involved in RA metabolism and actions (rdh10a, aldh1a2, crbp1, igf2r, rarg and cyp26a1) to adapt to a low-RA environment...
  72. Haushalter C, Schuhbaur B, Dolle P, Rhinn M. Meningeal retinoic acid contributes to neocortical lamination and radial migration during mouse brain development. Biol Open. 2017;6:148-160 pubmed publisher
    ..Its later production in the meninges by the retinaldehyde dehydrogenase RALDH2 coincides with the time of cortical neuron generation...
  73. Tweedle J, Deepe G. Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection. Infect Immun. 2018;86: pubmed publisher
    ..CD11b+ CD103+ DCs from TNF-neutralized mice displayed higher retinaldehyde dehydrogenase 2 (RALDH2) gene expression, and CD11b+ CD103+ RALDH+ DCs exhibited greater enzyme activity...
  74. Unguryte A, Bernotiene E, Bagdonas E, Garberyte S, Porvaneckas N, Jorgensen C. Human articular chondrocytes with higher aldehyde dehydrogenase activity have stronger expression of COL2A1 and SOX9. Osteoarthritis Cartilage. 2016;24:873-82 pubmed publisher
    ..Genes of isoenzymes ALDH1A2, ALDH1A3 and ALDH2 were strongly expressed, while ALDH1A1 was weakly expressed in chondrocytes...
  75. Zhao Y, Hou Y, Liu F, Liu A, Jing L, Zhao C, et al. Transcriptome Analysis Reveals that Vitamin A Metabolism in the Liver Affects Feed Efficiency in Pigs. G3 (Bethesda). 2016;6:3615-3624 pubmed publisher
    ..The key genes of VA metabolism (CYP1A1, ALDH1A2, and RDH16), fatty acid biosynthesis (FASN, SCD, CYP2J2, and ANKRD23), and ..
  76. Shabtai Y, Bendelac L, Jubran H, Hirschberg J, Fainsod A. Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity. Sci Rep. 2018;8:347 pubmed publisher
    ..In the embryo, RA production by RALDH2 (ALDH1A2), the main retinaldehyde dehydrogenase expressed at that stage, is inhibited by ethanol exposure...
  77. Jaurena M, Juraver Geslin H, Devotta A, Saint Jeannet J. Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Nat Commun. 2015;6:7476 pubmed publisher
    ..Among them we show that retinaldehyde dehydrogenase 2 (RALDH2) and lipocalin-type prostaglandin D2 synthase (LPGDS), which, respectively, regulate the synthesis and transport ..
  78. Shiokawa A, Kotaki R, Takano T, Nakajima Adachi H, Hachimura S. Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells. Immunology. 2017;152:52-64 pubmed publisher
    ..This subset expressed Aldh1a2 and Itgb8 genes, which are involved in retinoic acid metabolism and transforming growth factor-? (TGF-?) ..
  79. Dawicki W, Li C, Town J, Zhang X, Gordon J. Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3+CD49b-Foxp3- regulatory T cells. J Allergy Clin Immunol. 2017;139:1608-1620.e3 pubmed publisher
    ..Our data indicate that regulatory DC immunotherapy can be effective for food allergies and suggest that induction of Foxp3- regulatory T cells might be a useful strategy for tolerance induction in this context. ..
  80. Chen H, Babino D, Schoenbichler S, Arkhipova V, Töchterle S, Martin F, et al. Nmnat1-Rbp7 Is a Conserved Fusion-Protein That Combines NAD+ Catalysis of Nmnat1 with Subcellular Localization of Rbp7. PLoS ONE. 2015;10:e0143825 pubmed publisher
    ..regulated by the Nodal/FoxH1-signaling pathway and we show that Nodal/FoxH1 activity has the opposite effect on aldh1a2, which encodes the major enzyme for early embryonic retinoic acid production...
  81. Li Y, Wang L, Ai W, He N, Zhang L, Du J, et al. Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells. Int J Mol Med. 2017;40:661-672 pubmed publisher
    ..catalyze the oxidation of retinol to generate atRA, including aldehyde dehydrogenase 1 family (ALDH1)A1, ALDH1A2 and ALDH1A3, exhibit complex expression patterns at different stages of renal development...
  82. Goncalves M, Wu Y, Trigo D, Clarke E, Malmqvist T, Grist J, et al. Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth. Neurobiol Dis. 2018;111:70-79 pubmed publisher
    ..in RA synthesis in a cell specific manner; alcohol dehydrogenase7 (ADH7) in neurons and aldehyde dehydrogenase 2 (Raldh2) in NG2 expressing cells (NG2+ cells)...
  83. Ouimet M, Ediriweera H, Gundra U, Sheedy F, Ramkhelawon B, Hutchison S, et al. MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. J Clin Invest. 2015;125:4334-48 pubmed publisher
    ..macrophage expression of the retinoic acid-producing enzyme aldehyde dehydrogenase family 1, subfamily A2 (ALDH1A2) and retinal dehydrogenase activity both in vitro and in a mouse model...
  84. Becker J, May A, Gerges C, Anders M, Schmidt C, Veits L, et al. The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. Cancer Med. 2016;5:888-91 pubmed publisher
    ..study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence...
  85. Yokota Nakatsuma A, Ohoka Y, Takeuchi H, Song S, Iwata M. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties. Sci Rep. 2016;6:37914 pubmed publisher
    ..GM-CSF and RA contribute to the expression of the RA-producing enzyme ALDH1A2. However, additional signals appeared to be required for inducing ALDH1A2high mature DCs from immature ..
  86. Bowles J, Feng C, Miles K, Ineson J, Spiller C, Koopman P. ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries. Nat Commun. 2016;7:10845 pubmed publisher
    ..role of RA has been disputed principally because germ cells in embryos lacking two major RA-synthesizing enzymes, ALDH1A2 and ALDH1A3, remain able to enter meiosis...
  87. Kasimanickam V. Expression of retinoic acid-metabolizing enzymes, ALDH1A1, ALDH1A2, ALDH1A3, CYP26A1, CYP26B1 and CYP26C1 in canine testis during post-natal development. Reprod Domest Anim. 2016;51:901-909 pubmed publisher
    ..The objective was to elucidate gene expression of these RA-metabolizing enzymes (ALDH1A1, ALDH1A2, ALDH1A3, CYP26A1, CYP26B1 and CYP26C1) and their protein presence in testes of young, peripubertal and adult ..
  88. Lee J, Moon Y, Lee H, Park A, Choi S, Wang K, et al. Deregulation of Retinaldehyde Dehydrogenase 2 Leads to Defective Angiogenic Function of Endothelial Colony-Forming Cells in Pediatric Moyamoya Disease. Arterioscler Thromb Vasc Biol. 2015;35:1670-7 pubmed publisher
    ..expressed genes, we selected a gene with the most downregulated expression, retinaldehyde dehydrogenase 2 (RALDH2)...
  89. Diao J, Wang H, Chang N, Zhou X, Zhu X, Wang J, et al. PEG-PLA nanoparticles facilitate siRNA knockdown in adult zebrafish heart. Dev Biol. 2015;406:196-202 pubmed publisher
    ..This effect was demonstrated by down-regulation of the Aldh1a2 and Dusp6 proteins after intrapleural delivery of nanoparticle-encapsulated siRNAs...
  90. Cunningham T, Brade T, Sandell L, Lewandoski M, Trainor P, Colas A, et al. Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. PLoS ONE. 2015;10:e0137894 pubmed publisher
    ..Here, we found that mouse Raldh2-/- embryos, lacking RA synthesis and displaying a consistent small somite defect, exhibited abnormal expression of ..
  91. Kumar S, Cunningham T, Duester G. Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis. Dev Biol. 2016;418:204-215 pubmed publisher
    ..by CRISPR/Cas9 gene editing exhibited a small somite and distended heart phenotype similar to that of RA-deficient Raldh2-/- embryos, associated with increased Fgf8 expression and FGF signaling in caudal progenitors and heart ..
  92. Palles C, Findlay J, Tomlinson I. Common Variants Confer Susceptibility to Barrett's Esophagus: Insights from the First Genome-Wide Association Studies. Adv Exp Med Biol. 2016;908:265-90 pubmed publisher
    ..development of the foregut are adjacent to 6 of the loci identified (FOXF1, BARX1, FOXP1, GDF7, TBX5, and ALDH1A2)...