ALDH1A1

Summary

Gene Symbol: ALDH1A1
Description: aldehyde dehydrogenase 1 family member A1
Alias: ALDC, ALDH-E1, ALDH1, ALDH11, HEL-9, HEL-S-53e, HEL12, PUMB1, RALDH1, retinal dehydrogenase 1, ALDH class 1, ALHDII, RALDH 1, acetaldehyde dehydrogenase 1, aldehyde dehydrogenase 1, soluble, aldehyde dehydrogenase, liver cytosolic, epididymis luminal protein 12, epididymis luminal protein 9, epididymis secretory sperm binding protein Li 53e, retinaldehyde dehydrogenase 1
Species: human
Products:     ALDH1A1

Top Publications

  1. Ginestier C, Hur M, Charafe Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell. 2007;1:555-67 pubmed publisher
    ..In a series of 577 breast carcinomas, expression of ALDH1 detected by immunostaining correlated with poor prognosis...
  2. Zheng C, Wang T, Weiner H. Cloning and expression of the full-length cDNAS encoding human liver class 1 and class 2 aldehyde dehydrogenase. Alcohol Clin Exp Res. 1993;17:828-31 pubmed
    ..26 units/mg. The expressed mitochondrial isozyme could be recognized by antibodies raised against rat mitochondrial ALDH, whereas the cytosolic isozyme could be recognized by antibody raised against horse cytosolic ALDH. ..
  3. Spence J, Liang T, Eriksson C, Taylor R, Wall T, Ehlers C, et al. Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations. Alcohol Clin Exp Res. 2003;27:1389-94 pubmed
    Cytosolic aldehyde dehydrogenase, or ALDH1A1, functions in ethanol detoxification, metabolism of neurotransmitters, and synthesis of retinoic acid...
  4. Moore S, Montane Jaime K, Shafe S, Joseph R, Crooks H, Carr L, et al. Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and Tobago. J Stud Alcohol Drugs. 2007;68:192-6 pubmed
    Two polymorphisms in the promoter region of the gene encoding cytosolic aldehyde dehydrogenase (ALDH1A1), ALDH1A1*2 and ALDH1A1*3, have recently been identified...
  5. Chute J, Muramoto G, Whitesides J, Colvin M, Safi R, Chao N, et al. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2006;103:11707-12 pubmed
    ..Modulation of ALDH activity and retinoid signaling is a previously unrecognized and effective strategy to amplify human HSCs...
  6. Nogami T, Shien T, Tanaka T, Nishiyama K, Mizoo T, Iwamto T, et al. Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1-3 lymph node metastases. Breast Cancer. 2014;21:58-65 pubmed publisher
    ..On the other hand, it has been reported that the expression of aldehyde dehydrogenase 1 (ALDH1) in primary breast cancer is a powerful predictor of a poor clinical outcome, and that breast cancer stem cells ..
  7. Carpentino J, Hynes M, Appelman H, Zheng T, Steindler D, Scott E, et al. Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res. 2009;69:8208-15 pubmed publisher
    ..These data link colitis and cancer identifying potential tumor-initiating cells from colitic patients, suggesting that sphere and/or xenograft formation will be useful to survey colitic patients at risk of developing cancer. ..
  8. Todaro M, Iovino F, Eterno V, Cammareri P, Gambara G, Espina V, et al. Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Res. 2010;70:8874-85 pubmed publisher
    ..The identification of tumorigenic and metastagenic thyroid cancer cells may provide unprecedented preclinical tools for development and preclinical validation of novel targeted therapies...
  9. Morimoto K, Kim S, Tanei T, Shimazu K, Tanji Y, Taguchi T, et al. Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression. Cancer Sci. 2009;100:1062-8 pubmed publisher
    ..The aim of our study was to investigate the clinicopathological characteristics of breast cancers with ALDH1+ cancer stem cells...

More Information

Publications77

  1. Chang B, Liu G, Xue F, Rosen D, Xiao L, Wang X, et al. ALDH1 expression correlates with favorable prognosis in ovarian cancers. Mod Pathol. 2009;22:817-23 pubmed publisher
    Aldehyde dehydrogenase 1 (ALDH1), a detoxifying enzyme responsible for the oxidation of intracellular aldehydes, was shown to have a function in the early differentiation of stem cells, through its function in oxidizing retinol to ..
  2. Ehlers C, Spence J, Wall T, Gilder D, Carr L. Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California Indians. Alcohol Clin Exp Res. 2004;28:1481-6 pubmed
    Cytosolic aldehyde dehydrogenase (ALDH1A1) is an important enzyme in the metabolism of acetaldehyde and the synthesis of retinoic acid...
  3. Galter D, Buervenich S, Carmine A, Anvret M, Olson L. ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia. Neurobiol Dis. 2003;14:637-47 pubmed
    ..We investigated mRNA expression of the cytosolic aldehyde dehydrogenase (ALDH1), presumably involved in DA degradation, by in situ hybridization in DA neurons of human postmortem material...
  4. Raghunathan L, Hsu L, Klisak I, Sparkes R, Yoshida A, Mohandas T. Regional localization of the human genes for aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2. Genomics. 1988;2:267-9 pubmed
    We have used the cDNA probes for human aldehyde dehydrogenase-1 (ALDH1) and aldehyde dehydrogenase-2 (ALDH2) to determine regional chromosomal locations of these two genes by in situ hybridization...
  5. Okudela K, Woo T, Mitsui H, Suzuki T, Tajiri M, Sakuma Y, et al. Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance. Int J Clin Exp Pathol. 2013;6:1-12 pubmed
    b>ALDH1A1 metabolizes a variety of endogenous and exogenous aldehyde, and also oxidizes retinol to synthesize retinoic acid and modulate cell differentiation...
  6. Heerma van Voss M, van der Groep P, Bart J, van der Wall E, van Diest P. Expression of the stem cell marker ALDH1 in BRCA1 related breast cancer. Cell Oncol (Dordr). 2011;34:3-10 pubmed publisher
    ..Since ALDH1 is a marker of both mammary stem cells and breast cancer stem cells, we compared ALDH1 expression in malignant ..
  7. Dimou A, Neumeister V, Agarwal S, Anagnostou V, Syrigos K, Rimm D. Measurement of aldehyde dehydrogenase 1 expression defines a group with better prognosis in patients with non-small cell lung cancer. Am J Pathol. 2012;181:1436-42 pubmed publisher
    Aldehyde dehydrogenase 1 (ALDH1) has been suggested as a surrogate biomarker for cancer stem cells in breast cancer and other tumors...
  8. Su Y, Qiu Q, Zhang X, Jiang Z, Leng Q, Liu Z, et al. Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. Cancer Epidemiol Biomarkers Prev. 2010;19:327-37 pubmed publisher
    Aldehyde dehydrogenase 1 A1 (ALDH1A1) has recently been suggested as a marker for cancer stem or stem-like cancer cells of some human malignancies...
  9. Neumeister V, Agarwal S, Bordeaux J, Camp R, Rimm D. In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am J Pathol. 2010;176:2131-8 pubmed publisher
    ..They are characterized by CD44 positivity, CD24 negativity, and/or ALDH1 positivity in flow cytometric studies...
  10. Hsu L, Chang W, Yoshida A. Genomic structure of the human cytosolic aldehyde dehydrogenase gene. Genomics. 1989;5:857-65 pubmed
    ..They span about 80 kbp and include the entire human cytosolic aldehyde dehydrogenase (ALDH1) gene...
  11. Tan E, Thike A, Tan P. ALDH1 expression is enriched in breast cancers arising in young women but does not predict outcome. Br J Cancer. 2013;109:109-13 pubmed publisher
    ..In this study, we used ALDH1 as a CSC marker and determined whether ALDH1 expression correlated with clinical outcome in young women with ..
  12. Kim M, Fleming J, Wang H, Abbruzzese J, Choi W, Kopetz S, et al. ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PLoS ONE. 2011;6:e20636 pubmed publisher
    ..We have thus identified a distinct population of TICs that should lead to identification of novel targets for pancreatic cancer therapy. ..
  13. Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Kobayashi J, Sasaki T, et al. High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis. Pathol Int. 2012;62:684-9 pubmed publisher
    ..Aldehyde dehydrogenase 1 - (ALDH1) and SRY-related HMG-box gene 2 (SOX2) have recently been shown to be putative CSC markers for several human ..
  14. Avoranta S, Korkeila E, Ristamäki R, Syrjanen K, Carpén O, Pyrhönen S, et al. ALDH1 expression indicates chemotherapy resistance and poor outcome in node-negative rectal cancer. Hum Pathol. 2013;44:966-74 pubmed publisher
    The cancer stem cell marker aldehyde dehydrogenase 1 (ALDH1) associates with treatment resistance and adverse outcome in several human cancers...
  15. Chen Y, Chen Y, Hsu H, Tseng L, Huang P, Lu K, et al. Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochem Biophys Res Commun. 2009;385:307-13 pubmed publisher
    Aldehyde dehydrogenase 1 (ALDH1) has been considered to be a marker for cancer stem cells. However, the role of ALDH1 in head and neck squamous cell carcinoma (HNSCC) has yet to be determined...
  16. Landen C, Goodman B, Katre A, Steg A, Nick A, Stone R, et al. Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer. Mol Cancer Ther. 2010;9:3186-99 pubmed publisher
    Aldehyde dehydrogenase-1A1 (ALDH1A1) expression characterizes a subpopulation of cells with tumor-initiating or cancer stem cell properties in several malignancies...
  17. Deng S, Yang X, Lassus H, Liang S, Kaur S, Ye Q, et al. Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS ONE. 2010;5:e10277 pubmed publisher
    Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the identification of cancer stem cells...
  18. Lugli A, Iezzi G, Hostettler I, Muraro M, Mele V, Tornillo L, et al. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer. 2010;103:382-90 pubmed publisher
    ..prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer...
  19. Li T, Su Y, Mei Y, Leng Q, Leng B, Liu Z, et al. ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest. 2010;90:234-44 pubmed publisher
    ..Increased aldehyde dehydrogenase 1A1 (ALDH1A1) activity has been found in the stem cell populations of leukemia and some solid tumors...
  20. Wang K, Chen X, Zhan Y, Jiang W, Liu X, Wang X, et al. Increased expression of ALDH1A1 protein is associated with poor prognosis in clear cell renal cell carcinoma. Med Oncol. 2013;30:574 pubmed publisher
    Aldehyde dehydrogenase 1A1 (ALDH1A1) has been characterized as a cancer stem cell marker in different types of tumors...
  21. Eirew P, Kannan N, Knapp D, Vaillant F, Emerman J, Lindeman G, et al. Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells. Stem Cells. 2012;30:344-8 pubmed publisher
    ..In contrast, ALDH1A1 is expressed at low levels in all mammary epithelial cells...
  22. Sullivan J, Spinola M, Dodge M, Raso M, Behrens C, Gao B, et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res. 2010;70:9937-48 pubmed publisher
    ..Immunohistochemical staining of a large panel of primary non-small cell lung cancer (NSCLC) samples for ALDH1A1, ALDH3A1, and CD133 revealed a significant correlation between ALDH1A1 (but not ALDH3A1 or CD133) expression and ..
  23. Ma S, Chan K, Lee T, Tang K, Wo J, Zheng B, et al. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res. 2008;6:1146-53 pubmed publisher
    ..ALDH, expressed along CD133, can more specifically characterize the tumorigenic liver CSC population. ..
  24. Lohberger B, Rinner B, Stuendl N, Absenger M, Liegl Atzwanger B, Walzer S, et al. Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma. PLoS ONE. 2012;7:e43664 pubmed publisher
    ..Aldehyde dehydrogenase 1 (ALDH1) activity has been used as a functional stem cell marker to isolate CSCs in different cancer types...
  25. Dong Y, Bi L, Xu N, Yang H, Zhang H, Ding Y, et al. The expression of aldehyde dehydrogenase 1 in invasive primary breast tumors and axillary lymph node metastases is associated with poor clinical prognosis. Pathol Res Pract. 2013;209:555-61 pubmed publisher
    The enzyme aldehyde dehydrogenase 1 (ALDH1) has been reported as a biomarker for identifying cancer stem cells. Previous studies have shown that ALDH1 expression in primary breast cancers was associated with poor clinical prognosis...
  26. Nishida S, Hirohashi Y, Torigoe T, Kitamura H, Takahashi A, Masumori N, et al. Gene expression profiles of prostate cancer stem cells isolated by aldehyde dehydrogenase activity assay. J Urol. 2012;188:294-9 pubmed publisher
    ..The human prostate cancer cell line 22Rv1 was labeled with ALDEFLUOR reagent and analyzed by flow cytometry. ALDH1(high) and ALDH1(low) cells were isolated and tumorigenicity was evaluated by xenograft transplantation into NOD/..
  27. Luo Y, Dallaglio K, Chen Y, Robinson W, Robinson S, McCarter M, et al. ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. Stem Cells. 2012;30:2100-13 pubmed publisher
    ..These cells possess high aldehyde dehydrogenase (ALDH) activity with ALDH1A1 and ALDH1A3 being the predominant ALDH isozymes...
  28. Ozbek E, Calik G, Otunctemur A, Aliskan T, Cakir S, Dursun M, et al. Stem cell markers aldehyde dehydrogenase type 1 and nestin expressions in renal cell cancer. Arch Ital Urol Androl. 2012;84:7-11 pubmed
    ..There is a need to perform more studies about stem cell markers in RCC with more patients and in these future studies lymph node metastasis, distant organ metastasis and survival rates should be included. ..
  29. Hsu L, Yoshida A, Mohandas T. Chromosomal assignment of the genes for human aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2. Am J Hum Genet. 1986;38:641-8 pubmed
    ..of the genes for two major human aldehyde dehydrogenase isozymes, that is, cytosolic aldehyde dehydrogenase-1 (ALDH1) and mitochondrial aldehyde dehydrogenase-2 (ALDH2) were determined...
  30. Ohi Y, Umekita Y, Yoshioka T, Souda M, Rai Y, Sagara Y, et al. Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple-negative breast cancer. Histopathology. 2011;59:776-80 pubmed publisher
    Aldehyde dehydrogenase 1 (ALDH1) has been identified as a reliable marker of breast cancer stem cells, and its clinical significance as a prognostic indicator of breast cancer has been reported by several investigators...
  31. De Brot M, Rocha R, Soares F, Gobbi H. Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal-like breast cancers. Pathology. 2012;44:303-12 pubmed publisher
    We assessed the expression of ALDH1 and EZH2, cancer stem cell (CSC) related markers, in triple negative and basal-like breast cancers, investigating their association with clinicopathological features and outcome...
  32. Kunju L, Cookingham C, Toy K, Chen W, Sabel M, Kleer C. EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development. Mod Pathol. 2011;24:786-93 pubmed publisher
    ..049, respectively). Our study provides first evidence that EZH2 and epithelial and stromal ALDH-1 detection in benign breast biopsies may predict increased risk for breast cancer, with implications for breast cancer prevention. ..
  33. Yoshioka T, Umekita Y, Ohi Y, Souda M, Sagara Y, Sagara Y, et al. Aldehyde dehydrogenase 1 expression is a predictor of poor prognosis in node-positive breast cancers: a long-term follow-up study. Histopathology. 2011;58:608-16 pubmed publisher
    Aldehyde dehydrogenase 1 (ALDH1) has been identified as a reliable marker of breast cancer stem cells. The aim was to determine the prognostic significance of ALDH1 expression in a long-term follow-up study...
  34. King G, Holmes R. Human ocular aldehyde dehydrogenase isozymes: distribution and properties as major soluble proteins in cornea and lens. J Exp Zool. 1998;282:12-7 pubmed
    ..2.1.3) exhibit very high levels of activity in anterior eye tissues. Human corneal ALDH1 and ALDH3 isozymes are present as major soluble proteins (3% and 5%, respectively, of corneal soluble protein) and ..
  35. Vogler T, Kriegl L, Horst D, Engel J, Sagebiel S, Schäffauer A, et al. The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors. Exp Mol Pathol. 2012;92:111-7 pubmed publisher
    Aldehyde dehydrogenase-1 (ALDH1) is involved in the regulation of cell proliferation and differentiation. Moreover, it is a marker for cancer stem cells (CSC)...
  36. Wang Y, Zhe H, Gao P, Zhang N, Li G, Qin J. Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China. Dis Esophagus. 2012;25:560-5 pubmed publisher
    ..Aldehyde dehydrogenase 1 (ALDH1) has been proposed as one of the possible candidates for a CSC marker...
  37. Khoury T, Ademuyiwa F, Chandrasekhar R, Chandraseekhar R, Jabbour M, DeLeo A, et al. Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy. Mod Pathol. 2012;25:388-97 pubmed publisher
    Studies have shown that ALDH1A1 expression in the breast is associated with worse clinical outcome. ALDH1A1 inactivates cyclophosphamide, which is an integral agent in breast cancer chemotherapy regimens...
  38. Resetkova E, Reis Filho J, Jain R, Mehta R, Thorat M, Nakshatri H, et al. Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment. Breast Cancer Res Treat. 2010;123:97-108 pubmed publisher
    ..In this study, we sought to examine the prognostic relevance of ALDH1, a putative cancer stem cell marker, by immunohistochemistry...
  39. Kim H, Jung M, Choi S, Moon W, Kim S. Different Biological Action of Oleic Acid in ALDHhigh and ALDHlow Subpopulations Separated from Ductal Carcinoma In Situ of Breast Cancer. PLoS ONE. 2016;11:e0160835 pubmed publisher
    ..COM cells. OA led to an increase in the expression of ALDH1A1, ALDH1A2 and ALDH1A3 in MCF10DCIS.COM cells...
  40. Yue C, Zhao X, Tian C, Jin Y, Liu H. [High aldehyde dehydrogenase 1A1 (ALDH1A1) expression correlated with risk of lymph node metastasis in papillary thyroid carcinoma]. Zhonghua Bing Li Xue Za Zhi. 2015;44:490-4 pubmed
    To investigate the relationship between ALDH1A1 expression and lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC)...
  41. Unguryte A, Bernotiene E, Bagdonas E, Garberyte S, Porvaneckas N, Jorgensen C. Human articular chondrocytes with higher aldehyde dehydrogenase activity have stronger expression of COL2A1 and SOX9. Osteoarthritis Cartilage. 2016;24:873-82 pubmed publisher
    ..Genes of isoenzymes ALDH1A2, ALDH1A3 and ALDH2 were strongly expressed, while ALDH1A1 was weakly expressed in chondrocytes. Only ALDH1A2 and ALDH1A3 were significantly enriched in ALDH(+) fraction...
  42. Matsumoto A, Arcaroli J, Chen Y, Gasparetto M, Neumeister V, Thompson D, et al. Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer. Br J Cancer. 2017;117:1537-1543 pubmed publisher
    ..We recently reported that ALDH1B1, which has functional roles in tumourigenesis, may be a better CRC marker than ALDH1A1. Human CRC explants and cell lines were analysed to identify candidate CRC markers from eight ALDH isozymes ..
  43. Yasmeen R, Meyers J, Alvarez C, Thomas J, Bonnegarde Bernard A, Alder H, et al. Aldehyde dehydrogenase-1a1 induces oncogene suppressor genes in B cell populations. Biochim Biophys Acta. 2013;1833:3218-3227 pubmed publisher
    ..We provide evidence that the retinoic acid-producing enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) is an oncogene suppressor in specific splenic IgG1(+)/CD19(-) and IgG1(+)/CD19(+) B cell populations...
  44. Kim I, Lee J, Kim S, Kim J, Cho E. Fibulin-3 negatively regulates ALDH1 via c-MET suppression and increases γ-radiation-induced sensitivity in some pancreatic cancer cell lines. Biochem Biophys Res Commun. 2014;454:369-75 pubmed publisher
    ..Moreover, we also showed that c-MET suppression or inactivation decreased the cellular level of ALDH1 isozymes (ALDH1A1 or ALDH1A3), which serve as cancer stem cell markers, and subsequently induced inhibition of cell growth in ..
  45. Yu X, Zhang F, Mao J, Lu Y, Li J, Ma W, et al. Protein tyrosine phosphatase receptor-type ? acts as a negative regulator suppressing breast cancer. Oncotarget. 2017;8:98798-98811 pubmed publisher
    ..breast cancer stem cell (BCSC) population and the expression of the stem cell markers ALDH1 and OCT4...
  46. Inukai M, Hara A, Yasui Y, Kumabe T, Matsumoto T, Saegusa M. Hypoxia-mediated cancer stem cells in pseudopalisades with activation of hypoxia-inducible factor-1α/Akt axis in glioblastoma. Hum Pathol. 2015;46:1496-505 pubmed publisher
    ..Inhibition of endogenous Akt by LY294002 resulted in decreased expression of Sox2, ALDH1, and CD133, leading to enhancement of cobalt chloride-mediated apoptotic events due to altered ratio of bcl-2 to ..
  47. Yang X, Lin X, Zhong X, Kaur S, Li N, Liang S, et al. Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res. 2010;70:9463-72 pubmed publisher
    A relatively rare aldehyde dehydrogenase 1 (ALDH1)-positive "stem cell-like" subpopulation of tumor cells has the unique ability to initiate and perpetuate tumor growth; moreover, it is highly resistant to chemotherapy and ..
  48. Metri R, Mohan A, Nsengimana J, Poźniak J, Molina París C, Newton Bishop J, et al. Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach. Sci Rep. 2017;7:17314 pubmed publisher
    ..From this, we identified a panel of 6 genes, ALDH1A1, HSP90AB1, KIT, KRT16, SPRR3 and TMEM45B whose expression values discriminated metastatic from primary melanoma (..
  49. Yassin F. Aldehyde dehyderogenase (ALDH1A1) delineating the normal and cancer stem cells in spectral lung lesions: An immunohistochemical appraisal. Pathol Res Pract. 2016;212:398-409 pubmed publisher
    b>ALDH1A1 is one of the promising cancer stem cell markers, it has been found in different cancers, including lung cancer...
  50. Abdul Amin S, Adhikari N, Gayen S, Jha T. Insight into the Structural Requirements of Theophylline-Based Aldehyde Dehydrogenase lAl (ALDHlAl) Inhibitors Through Multi-QSAR Modeling and Molecular Docking Approaches. Curr Drug Discov Technol. 2016;13:84-100 pubmed
    Over expression of aldehyde dehydrogenase (ALDH1A1) is one of the vital hallmarks of the self-renewal and differentiational cancer stem cells (CSCs). Till now, no selective ALDH1A1 inhibitor is commercially available in the market...
  51. Strzalka Mrozik B, Prudlo L, Kimsa M, Kimsa M, Kapral M, Nita M, et al. Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome. Mol Vis. 2013;19:1341-9 pubmed
    ..enzymes involved in the antioxidant defense system (superoxide dismutase 2, SOD2; aldehyde dehydrogenase 1, ALDH1A1; microsomal glutathione S-transferase 1, MGST1) in fragments of anterior lens capsules of patients with ..
  52. DA Cruz Paula A, Marques O, Rosa A, DE Fátima Faria M, Rema A, Lopes C. Co-expression of stem cell markers ALDH1 and CD44 in non-malignant and neoplastic lesions of the breast. Anticancer Res. 2014;34:1427-34 pubmed
    ..Enzymatic activity of aldehyde dehydrogenase-1 (ALDH1), a de-toxifying enzyme that oxidizes intracellular aldehydes, has been used as a marker of normal and malignant ..
  53. Liu T, Sun B, Zhao X, Li Y, Zhao X, Liu Y, et al. USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry. Mol Cancer Ther. 2015;14:2121-31 pubmed publisher
    ..Finally, USP44(+) CSC subclones (ALDH1(+)/USP44(+)/IL6(+)/IL8(+)) were identified in breast cancer specimens through consecutive sections scanning...
  54. Jiang Y, Li H, Wang Y, Tian T, He Y, Jin Y, et al. ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line. Oncol Lett. 2017;14:6955-6961 pubmed publisher
    ..The regulated enzyme activity of ALDH was analyzed by flow cytometry in the A549 cell line. ALDH1 and Nodal expression was investigated by immunohistochemistry in28 cases of lung mixed adenocarcinoma...
  55. Nozaki Y, Tamori S, Inada M, Katayama R, Nakane H, Minamishima O, et al. Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer. Genes Cancer. 2017;8:628-639 pubmed publisher
    ..These c-Met inhibitors also suppressed cell viability and tumor-sphere formation of ALDH1high breast cancer cells with high c-Met expression...
  56. Inoue R, Hirohashi Y, Kitamura H, Nishida S, Murai A, Takaya A, et al. GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis. Oncotarget. 2017;8:28826-28839 pubmed publisher
    ..Immunohistochemical staining revealed that higher levels of GRIK2 and ALDH1 expression were related to poorer prognosis in urinary tract carcinoma cases...
  57. Xu S, Tang Y, Yu Y, Yun Q, Yang J, Zhang H, et al. Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma. Drug Deliv. 2017;24:1139-1147 pubmed publisher
    ..tumor growth, prolonging survival time, decreasing expression of CD31, CD133, and aldehyde dehydrogenase 1 (ALDH1), inducing G2/M phase arrest, apoptosis, and expression of Ataxia telangiectasia mutated (ATM) and histone H2AX ..
  58. Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, et al. Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway. J Cell Biochem. 2018;119:4134-4141 pubmed publisher
    ..CSCs as evidenced by reducing turmorspheres formation, decreasing the expression of breast CSCs markers (CD44, ALDH1A1, Nanog, and Oct4), as well as inhibiting proliferation and inducing apoptosis...
  59. Ayub T, Keyver Paik M, Debald M, Rostamzadeh B, Thiesler T, Schröder L, et al. Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer. Oncotarget. 2015;6:16437-48 pubmed
    ..All used markers of stemness (ALDH1, CD24, CD117, CD133) isolated low frequencies of malignant cells...
  60. Papadaki M, Kallergi G, Zafeiriou Z, Manouras L, Theodoropoulos P, Mavroudis D, et al. Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer. BMC Cancer. 2014;14:651 pubmed publisher
    ..A new methodology was developed in order to investigate the co-expression of a stemness and an EMT marker (ALDH1 and TWIST, respectively) on single CTCs of patients with early and metastatic breast cancer...
  61. Yasgar A, Titus S, Wang Y, Danchik C, Yang S, Vasiliou V, et al. A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity. PLoS ONE. 2017;12:e0170937 pubmed publisher
    ..Increased expression of ALDH1A1 has been identified in a wide-range of human cancer stem cells and is associated with cancer relapse and poor ..
  62. Yan Z, Xu L, Zhang J, Lu Q, Luo S, Xu L. Aldehyde dehydrogenase 1A1 stabilizes transcription factor Gli2 and enhances the activity of Hedgehog signaling in hepatocellular cancer. Biochem Biophys Res Commun. 2016;471:466-73 pubmed publisher
    ..Using a differential mass-spectrometry approach, we found that aldehyde dehydrogenase 1A1 (ALDH1A1) is associated with transcription factor Gli2...
  63. Seneviratne A, Bell G, Sherman S, Cooper T, Putman D, Hess D. Expanded Hematopoietic Progenitor Cells Reselected for High Aldehyde Dehydrogenase Activity Demonstrate Islet Regenerative Functions. Stem Cells. 2016;34:873-87 pubmed publisher
    ..Thus, expansion and delivery of reselected UCB cells that retain high ALDH-activity after short-term culture represents an improved strategy for the development of cellular therapies to enhance islet regeneration in situ. ..
  64. Ajani J, Wang X, Song S, Suzuki A, Taketa T, Sudo K, et al. ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients. Mol Oncol. 2014;8:142-9 pubmed publisher
    ..Our clinical and non-clinical data demonstrate that ALDH-1 LIs are predictive of response to therapy and further research could lead to individualized therapeutic strategies and novel therapeutic targets for EC patients. ..
  65. Kuroda T, Hirohashi Y, Torigoe T, Yasuda K, Takahashi A, Asanuma H, et al. ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis. PLoS ONE. 2013;8:e65158 pubmed publisher
    ..We isolated ovarian CSCs/CICs as an aldehyde dehydrogenase 1 high (ALDH1(high)) population from 6 EOC cell lines (3 serous adenocarcinomas and 3 clear cell adenocarcinomas) by the ..
  66. Schwartz T, Stark A, Pang J, Awuah B, Kleer C, Quayson S, et al. Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women. Cancer. 2013;119:488-94 pubmed publisher
    ..Little is known about expression of the mammary stem cell marker aldehyde dehydrogenase 1 (ALDH1) in African women...
  67. Yao T, Chen Q, Zhang B, Zhou H, Lin Z. The expression of ALDH1 in cervical carcinoma. Med Sci Monit. 2011;17:HY21-26 pubmed
    b>ALDH1 has been shown to play a role in the early differentiation of stem cells in some human malignancies. Whether cancer stem cells occur in ALDH1-associated cervical cancer is not known...
  68. Lin C, Hsieh P, Liao Y, Peng C, Lu M, Yang C, et al. Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cells. Oncotarget. 2017;8:80900-80908 pubmed publisher
    ..Our results demonstrated that berberine dose dependently downregulated the oncogenicity in vitro, including ALDH1 activity, self-renewal property, and colony formation and invasion abilities as well as potentiated ..