ALCAM

Summary

Gene Symbol: ALCAM
Description: activated leukocyte cell adhesion molecule
Alias: CD166, MEMD, CD166 antigen
Species: human
Products:     ALCAM

Top Publications

  1. Ihnen M, Muller V, Wirtz R, Schroder C, Krenkel S, Witzel I, et al. Predictive impact of activated leukocyte cell adhesion molecule (ALCAM/CD166) in breast cancer. Breast Cancer Res Treat. 2008;112:419-27 pubmed publisher
    Activated Leukocyte Cell Adhesion Molecule (ALCAM, also called CD 166, MEMD) as cell surface immunoglobulin is reported as prognostic marker in breast cancer, but its predictive value has not yet been evaluated...
  2. King J, Tan F, Mbeunkui F, Chambers Z, Cantrell S, Chen H, et al. Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancer. Mol Cancer. 2010;9:266 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM) is implicated in the prognosis of multiple cancers with low level expression associated with metastasis and early death in breast cancer...
  3. Tan F, Ghosh S, Mbeunkui F, Thomas R, Weiner J, Ofori Acquah S. Essential role for ALCAM gene silencing in megakaryocytic differentiation of K562 cells. BMC Mol Biol. 2010;11:91 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM/CD166) is expressed by hematopoietic stem cells. However, its role in hematopoietic differentiation has not previously been defined...
  4. Horst D, Kriegl L, Engel J, Kirchner T, Jung A. Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer. Cancer Invest. 2009;27:844-50 pubmed publisher
    CD133, CD44, and CD166 are cell surface markers that have recently been associated with colorectal cancer stem cells...
  5. Mezzanzanica D, Fabbi M, Bagnoli M, Staurengo S, Losa M, Balladore E, et al. Subcellular localization of activated leukocyte cell adhesion molecule is a molecular predictor of survival in ovarian carcinoma patients. Clin Cancer Res. 2008;14:1726-33 pubmed publisher
    ..In a retrospective study, we investigated the prognostic impact of activated leukocyte cell adhesion molecule (ALCAM) expression in epithelial ovarian cancer...
  6. Lugli A, Iezzi G, Hostettler I, Muraro M, Mele V, Tornillo L, et al. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer. 2010;103:382-90 pubmed publisher
    The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer...
  7. Masedunskas A, King J, Tan F, Cochran R, Stevens T, Sviridov D, et al. Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration. FEBS Lett. 2006;580:2637-45 pubmed
    ..Activated leukocyte cell adhesion molecule (ALCAM/CD166) is an Ig CAM expressed by activated monocytes and endothelial cells...
  8. Levin T, Powell A, Davies P, Silk A, Dismuke A, Anderson E, et al. Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology. 2010;139:2072-2082.e5 pubmed publisher
    b>CD166 (also called activated leukocyte cell adhesion molecule [ALCAM]) is a marker of colorectal cancer (CRC) stem cells; it is expressed by aggressive tumors...
  9. Sawhney M, Matta A, Macha M, Kaur J, Dattagupta S, Shukla N, et al. Cytoplasmic accumulation of activated leukocyte cell adhesion molecule is a predictor of disease progression and reduced survival in oral cancer patients. Int J Cancer. 2009;124:2098-105 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM) has been proposed to function as a cell surface sensor for cell density, controlling the transition between local cell proliferation and tissue invasion in cancer progression...

More Information

Publications77

  1. Ofori Acquah S, King J. Activated leukocyte cell adhesion molecule: a new paradox in cancer. Transl Res. 2008;151:122-8 pubmed publisher
    The activated leukocyte cell adhesion molecule [ALCAM/CD166/melanoma metastasis clone D (MEMD)] is an immunoglobulin superfamily cell adhesion molecule. It is expressed developmentally in cells of all 3 embryonic lineages...
  2. Davies S, Dent C, Watkins G, King J, Mokbel K, Jiang W. Expression of the cell to cell adhesion molecule, ALCAM, in breast cancer patients and the potential link with skeletal metastasis. Oncol Rep. 2008;19:555-61 pubmed
    The activated leukocyte cell adhesion molecule (ALCAM) is involved in cell migration and adhesion. Decreased levels of ALCAM expression in breast cancer tissue are known to correlate with poor prognosis...
  3. Jezierska A, Matysiak W, Motyl T. ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. Med Sci Monit. 2006;12:BR263-73 pubmed
    Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a 105-kDa transmembrane glycoprotein linked with cell migration and development and with cancer progression (malignant melanoma, prostate cancer and, very recently, breast ..
  4. Ikeda K, Quertermous T. Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. J Biol Chem. 2004;279:55315-23 pubmed
    ..Recently, activated leukocyte cell adhesion molecule (ALCAM), a member of the Ig superfamily, has been detected in the primitive subsets of hematopoietic cells and ..
  5. Zimmerman A, Nelissen J, van Emst de Vries S, Willems P, de Lange F, Collard J, et al. Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases. J Cell Sci. 2004;117:2841-52 pubmed
    The activated leukocyte cell adhesion molecule (ALCAM) is dynamically regulated by the actin cytoskeleton...
  6. Weidle U, Eggle D, Klostermann S, Swart G. ALCAM/CD166: cancer-related issues. Cancer Genomics Proteomics. 2010;7:231-43 pubmed
    Activated leucocyte adhesion molecule (ALCAM) was originally identified as a transmembrane receptor which is involved in T-cell activation and has other still unresolved functions in hematopoiesis, development, inflammation and ..
  7. Lunter P, van Kilsdonk J, van Beek H, Cornelissen I, Bergers M, Willems P, et al. Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity. Cancer Res. 2005;65:8801-8 pubmed
    Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD) could function as a cell surface sensor for cell density, controlling the transition between local cell proliferation and tissue invasion in melanoma progression...
  8. Zimmerman A, Joosten B, Torensma R, Parnes J, van Leeuwen F, Figdor C. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. Blood. 2006;107:3212-20 pubmed
    ..Here, we show that CD6 and its ligand activated leukocyte cell adhesion molecule (ALCAM) are actively recruited to the antigen-induced dendritic cell (DC)-T-cell contact zone...
  9. Jiao J, Hindoyan A, Wang S, Tran L, Goldstein A, Lawson D, et al. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS ONE. 2012;7:e42564 pubmed publisher
    ..scheme, we searched for cell surface molecules upregulated upon castration of murine prostate and identified CD166 as a candidate gene...
  10. van Kempen L, Meier F, Egeblad M, Kersten Niessen M, Garbe C, Weidle U, et al. Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis. J Invest Dermatol. 2004;122:1293-301 pubmed
    ..melanoma is, among others, accompanied by de novo expression of activated leukocyte cell adhesion molecule (ALCAM/CD166) and enhanced activity of proteolytic cascades in the invasive, vertical growth phase (VGP) of lesions...
  11. Cayrol R, Wosik K, Berard J, Dodelet Devillers A, Ifergan I, Kebir H, et al. Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nat Immunol. 2008;9:137-45 pubmed
    ..Using a lipid raft-based proteomic approach, we identified ALCAM as an adhesion molecule involved in leukocyte migration across the blood-brain barrier (BBB)...
  12. van Kempen L, Nelissen J, Degen W, Torensma R, Weidle U, Bloemers H, et al. Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction. J Biol Chem. 2001;276:25783-90 pubmed
    Activated leukocyte cell adhesion molecule (ALCAM/CD166), a member of the immunoglobulin superfamily with five extracellular immunoglobulin-like domains, facilitates heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell ..
  13. Cortes F, Deschaseaux F, Uchida N, Labastie M, Friera A, He D, et al. HCA, an immunoglobulin-like adhesion molecule present on the earliest human hematopoietic precursor cells, is also expressed by stromal cells in blood-forming tissues. Blood. 1999;93:826-37 pubmed
    We have previously shown that the HCA/ALCAM (CD166) glycoprotein, a member of the immunoglobulin family that mediates both homophilic and heterophilic cell-cell adhesion, via the CD6 ligand, is expressed at the surface of all of the most ..
  14. Kahlert C, Weber H, Mogler C, Bergmann F, Schirmacher P, Kenngott H, et al. Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. Br J Cancer. 2009;101:457-64 pubmed publisher
    ALCAM (activated leucocyte cell adhesion molecule, synonym CD166) is a cell adhesion molecule, which belongs to the Ig superfamily...
  15. Davies S, Jiang W. ALCAM, activated leukocyte cell adhesion molecule, influences the aggressive nature of breast cancer cells, a potential connection to bone metastasis. Anticancer Res. 2010;30:1163-8 pubmed
    b>ALCAM, activated leukocyte cell adhesion molecule, is connected to the progression of certain solid tumours and has been shown to be a prominent feature for tumours that subsequently developed bone metastasis...
  16. Corrias M, Gambini C, Gregorio A, Croce M, Barisione G, Cossu C, et al. Different subcellular localization of ALCAM molecules in neuroblastoma: Association with relapse. Cell Oncol. 2010;32:77-86 pubmed publisher
    The Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166), involved in nervous system development, has been linked to tumor progression and metastasis in several tumors...
  17. Piao D, Jiang T, Liu G, Wang B, Xu J, Zhu A. Clinical implications of activated leukocyte cell adhesion molecule expression in breast cancer. Mol Biol Rep. 2012;39:661-8 pubmed publisher
    ..150 breast cancer cases to investigate the expression status of activated leukocyte cell adhesion molecule (ALCAM), and the relationships between ALCAM expression and clinical-pathological characteristics and prognosis of breast ..
  18. Kulasingam V, Zheng Y, Soosaipillai A, Leon A, Gion M, Diamandis E. Activated leukocyte cell adhesion molecule: a novel biomarker for breast cancer. Int J Cancer. 2009;125:9-14 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis...
  19. Liang S, Huang C, Jia S, Wang B. Activated leukocyte cell adhesion molecule expression is up-regulated in the development of endometrioid carcinoma. Int J Gynecol Cancer. 2011;21:523-8 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a member of the immunoglobulin superfamily that contributes to cell migration...
  20. Tachezy M, Zander H, Marx A, Stahl P, Gebauer F, Izbicki J, et al. ALCAM (CD166) expression and serum levels in pancreatic cancer. PLoS ONE. 2012;7:e39018 pubmed publisher
    This study was conducted to evaluate the expression of the activated leukocyte cell adhesion molecule (ALCAM) in pancreatic cancer (PAC) and to determine whether or not the ectodomain shedding of ALCAM (s-ALCAM) could serve as a ..
  21. Verma A, Shukla N, Deo S, Gupta S, Ralhan R. MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in esophageal squamous cell carcinoma. Oncology. 2005;68:462-70 pubmed
    ..The aim of this study was to determine the clinical significance of MEMD/ALCAM in esophageal tumorigenesis...
  22. Kijima N, Hosen N, Kagawa N, Hashimoto N, Nakano A, Fujimoto Y, et al. CD166/activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion. Neuro Oncol. 2012;14:1254-64 pubmed
    ..In this study, we found that the cluster of differentiation (CD)166/activated leukocyte cell adhesion molecule (ALCAM) was highly expressed on CD133+ glioblastoma progenitor cells...
  23. Bowen M, Patel D, Li X, Modrell B, Malacko A, Wang W, et al. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J Exp Med. 1995;181:2213-20 pubmed
    ..This antigen, which we named ALCAM (activated leukocyte-cell adhesion molecule) because of its expression on activated leukocytes, appears to be the ..
  24. Minner S, Kraetzig F, Tachezy M, Kilic E, Graefen M, Wilczak W, et al. Low activated leukocyte cell adhesion molecule expression is associated with advanced tumor stage and early prostate-specific antigen relapse in prostate cancer. Hum Pathol. 2011;42:1946-52 pubmed publisher
    Activated leukocyte cell adhesion molecule (CD166) is a member of the immunoglobulin superfamily and is aberrantly expressed in different tumors, including prostate cancer...
  25. Tachezy M, Zander H, Marx A, Gebauer F, Rawnaq T, Kaifi J, et al. ALCAM (CD166) expression as novel prognostic biomarker for pancreatic neuroendocrine tumor patients. J Surg Res. 2011;170:226-32 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM, CD166) is a cell membrane protein that is aberrantly expressed in different tumors, including pancreatic neuroendocrine tumors (PNET)...
  26. Jin Z, Selaru F, Cheng Y, Kan T, Agarwal R, Mori Y, et al. MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. Oncogene. 2011;30:1577-85 pubmed publisher
    ..05). Luciferase assays suggested that microRNA-215 inhibits activated leukocyte cell adhesion molecule (ALCAM) expression at the posttranscriptional level...
  27. Kilic E, Milde Langosch K, Muller V, Wirtz R, Ihnen M. [Expression of activated leukocyte cell adhesion molecule in breast cancer. Predictability of the response to taxane-free chemotherapy]. Pathologe. 2008;29 Suppl 2:347-52 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM) is a cell surface immunoglobulin expressed in breast cancer (BC) and is assumed to be implicated in tumourigenesis and tumour progression...
  28. Rosso O, Piazza T, Bongarzone I, Rossello A, Mezzanzanica D, Canevari S, et al. The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells. Mol Cancer Res. 2007;5:1246-53 pubmed publisher
    Previous findings indicated that the activated leukocyte cell adhesion molecule (ALCAM) is expressed by tumors and plays a role in tumor biology...
  29. Tomita K, Van Bokhoven A, Jansen C, Bussemakers M, Schalken J. Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin. Biochem Biophys Res Commun. 2000;267:870-4 pubmed
    ..we report on the role of alpha-catenin in the cellular localization of activated leukocyte cell adhesion molecule, ALCAM, and cadherin-mediated cell adhesion in human prostate cancer cells...
  30. Miccichè F, Da Riva L, Fabbi M, Pilotti S, Mondellini P, Ferrini S, et al. Activated leukocyte cell adhesion molecule expression and shedding in thyroid tumors. PLoS ONE. 2011;6:e17141 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM, CD166) is expressed in various tissues, cancers, and cancer-initiating cells...
  31. van Kilsdonk J, Wilting R, Bergers M, Van Muijen G, Schalkwijk J, van Kempen L, et al. Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule. Cancer Res. 2008;68:3671-9 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a marker of various cancers and mesenchymal stem cells, is involved in melanoma metastasis...
  32. Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N. Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens. J Immunol. 2006;177:877-84 pubmed
    ..By screening mAbs against a large panel of tumor cell lines, we found that the expression of CD166 closely paralleled the capacity of activating gammadelta T cells upon PAM treatment...
  33. Tachezy M, Zander H, Gebauer F, Marx A, Kaifi J, Izbicki J, et al. Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients. J Surg Res. 2012;177:e15-20 pubmed publisher
    The activated leukocyte cell adhesion molecule (ALCAM, CD166) has been reported to be involved in tumorigenesis of colorectal cancer (CRC) and to function as a cancer stem cell marker...
  34. Tachezy M, Effenberger K, Zander H, Minner S, Gebauer F, Vashist Y, et al. ALCAM (CD166) expression and serum levels are markers for poor survival of esophageal cancer patients. Int J Cancer. 2012;131:396-405 pubmed publisher
    The expression of the activated leukocyte cell adhesion molecule (ALCAM and CD166) is increased in various types of cancer. We aimed to evaluate its role as a prognostic marker for esophageal cancer (EC)...
  35. Degen W, van Kempen L, Gijzen E, van Groningen J, van Kooyk Y, Bloemers H, et al. MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). Am J Pathol. 1998;152:805-13 pubmed
    ..The encoded protein, MEMD, is identical to activated leukocyte cell adhesion molecule (ALCAM), a recently identified ligand of CD6...
  36. Kristiansen G, Pilarsky C, Wissmann C, Stephan C, Weissbach L, Loy V, et al. ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions. Prostate. 2003;54:34-43 pubmed
    Activated leukocyte cell adhesion molecule (ALCAM, CD166) is expressed in various tissues, including malignant melanoma, prostate cancer cell lines, and prostate cancer...
  37. Gao Y, Bielohuby M, Fleming T, Grabner G, Foppen E, Bernhard W, et al. Dietary sugars, not lipids, drive hypothalamic inflammation. Mol Metab. 2017;6:897-908 pubmed publisher
    ..advanced glycation end-products (AGEs) receptor (RAGE) and/or the activated leukocyte cell-adhesion molecule (ALCAM)...
  38. Wu J, Lu Y, Chen J, Wu S, Tang X, Li Y. [Pooled Umbilical Cord Blood Plasma for Culturing UCMSC and Ex Vivo Expanding Umbilical Cord Blood CD34⁺ Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:1112-9 pubmed publisher
    ..spindle-shaped and plastic-adherent), the immunophenotype (high positive percentage of CD73, CD90, CD105 and CD166) and the differentiation potential (osteogenic and adipogenic) were almost indistinguishable among the cells ..
  39. Hebron K, Li E, Arnold Egloff S, von Lersner A, Taylor C, Houkes J, et al. Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis. Sci Rep. 2018;8:3208 pubmed publisher
    ..We previously identified Activated Leukocyte Cell Adhesion Molecule (ALCAM) as a clinically relevant driver of metastasis and hypothesized that a tunable mechanism of ectodomain shedding ..
  40. Guadagno E, de Divitiis O, Solari D, Borrelli G, Bracale U, Di Somma A, et al. Can recurrences be predicted in craniopharyngiomas? β-catenin coexisting with stem cells markers and p-ATM in a clinicopathologic study of 45cases. J Exp Clin Cancer Res. 2017;36:95 pubmed publisher
    ..In this study, we measured the immunohistochemical expression of β-catenin, stem cell markers (CD133, CD166), Ki67 and pATMin 45 craniopharyngiomas and correlated it with clinicopathologic features...
  41. Hu X, García M, Weng L, Jung X, Murakami J, Kumar B, et al. Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche. Nat Commun. 2016;7:13095 pubmed publisher
    ..we identify a mesenchymal stromal progenitor hierarchy, where CD45-Ter119-CD31-CD166-CD146-Sca1+(Sca1+) progenitors give rise to CD45-Ter119..
  42. Jiang C, Ma P, Ma B, Wu Z, Qiu G, Su X, et al. Plasma-Derived Fibronectin Stimulates Chondrogenic Differentiation of Human Subchondral Cortico-Spongious Progenitor Cells in Late-Stage Osteoarthritis. Int J Mol Sci. 2015;16:19477-89 pubmed publisher
    ..Cells isolated from subchondral bone presented to be positive for CD44, CD73, CD90, and CD166, and showed high capacity of osteogenic, adipogenic and chondrogenic differentiation, which suggested this cell ..
  43. Escoda Ferran C, Carrasco E, Caballero Baños M, Miró Julià C, Martínez Florensa M, Consuegra Fernández M, et al. Modulation of CD6 function through interaction with Galectin-1 and -3. FEBS Lett. 2014;588:2805-13 pubmed publisher
    ..receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, ..
  44. Te Riet J, Helenius J, Strohmeyer N, Cambi A, Figdor C, Muller D. Dynamic coupling of ALCAM to the actin cortex strengthens cell adhesion to CD6. J Cell Sci. 2014;127:1595-606 pubmed publisher
    At the immunological synapse, the activated leukocyte cell adhesion molecule (ALCAM) on a dendritic cell (DC) and CD6 molecules on a T cell contribute to sustained DC-T-cell contacts...
  45. Li J, Niu Y, Xing Y, Liu F. A novel bispecific c-MET/CTLA-4 antibody targeting lung cancer stem cell-like cells with therapeutic potential in human non-small cell lung cancer. Biosci Rep. 2017;: pubmed publisher
    ..to epithelial transition factor (c-MET) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) in CD166+ LCSCs with high affinity and specificity, for the first time...
  46. Tachezy M, Zander H, Wolters Eisfeld G, Muller J, Wicklein D, Gebauer F, et al. Activated leukocyte cell adhesion molecule (CD166): an "inert" cancer stem cell marker for non-small cell lung cancer?. Stem Cells. 2014;32:1429-36 pubmed publisher
    Recently, the activated leukocyte cell adhesion molecule (CD166) was identified as an "inert" cancer stem cell (CSC) marker for non-small cell lung cancer (NSCLC)...
  47. Park E, Jeon S, Weon H, Cho H, Youn D. Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn. Neurosci Lett. 2017;656:9-14 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM), a member of type I transmembrane immunoglobulin superfamily of cell adhesion molecule, is expressed in the surface membrane of various cell types including neurons...
  48. Pang P, Chan K, Tse L, Chan R, Cheung Y, Sin F, et al. Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A *0201 restricted epitopes. Cancer Lett. 2007;256:178-85 pubmed
    ..The HCA661 peptides, H110 and H246, are hence attractive candidates for human cancer immunotherapy. ..
  49. Sulaj A, Kopf S, Gröne E, Gröne H, Hoffmann S, Schleicher E, et al. ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy. J Diabetes Complications. 2017;31:1058-1065 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM/CD166) functions analogue to the receptor of advanced glycation end products, which has been implicated in the development of diabetic nephropathy (DN)...
  50. Orta Mascaró M, Consuegra Fernández M, Carreras E, Roncagalli R, Carreras Sureda A, Alvarez P, et al. CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med. 2016;213:1387-97 pubmed publisher
    ..CD6 facilitates adhesion between T cells and antigen-presenting cells through its interaction with CD166/ALCAM (activated leukocyte cell adhesion molecule), and physically associates with the T cell receptor (TCR) at ..
  51. Takahashi I, Sato K, Mera H, Wakitani S, Takagi M. Effects of agitation rate on aggregation during beads-to-beads subcultivation of microcarrier culture of human mesenchymal stem cells. Cytotechnology. 2017;69:503-509 pubmed publisher
    ..The percentages of CD90- and CD166-positive cells among cells grown on Cytodex 1 at 60 rpm (91.5 and 87...
  52. He W, Huang L, Li M, Yang Y, Chen Z, Shen X. MiR-148b, MiR-152/ALCAM Axis Regulates the Proliferation and Invasion of Pituitary Adenomas Cells. Cell Physiol Biochem. 2017;44:792-803 pubmed publisher
    ..The aim of this study is to investigate the role of miR-148b, miR-152/ALCAM axis in human pituitary adenomas (PAs).
  53. Eom D, Hong S, Kim G, Bae Y, Jang K, Yu E. Prognostic Significance of CD44v6, CD133, CD166, and ALDH1 Expression in Small Intestinal Adenocarcinoma. Appl Immunohistochem Mol Morphol. 2015;23:682-8 pubmed publisher
    ..CD44v6, CD133, CD166, and ALDH1 have been proposed to be putative CSC markers in gastrointestinal malignancies...
  54. Tang X, Jing L, Richardson W, Isaacs R, Fitch R, Brown C, et al. Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. J Orthop Res. 2016;34:1316-26 pubmed publisher
    ..However, the increased expression of CD54 and CD166 with aging indicated that they might be referenced as the potential biomarker for disc degeneration...
  55. Asgari H, Akbari M, Yazdekhasti H, Rajabi Z, Navid S, Aliakbari F, et al. Comparison of Human Amniotic, Chorionic, and Umbilical Cord Multipotent Mesenchymal Stem Cells Regarding Their Capacity for Differentiation Toward Female Germ Cells. Cell Reprogram. 2017;19:44-53 pubmed publisher
    ..Results showed that all isolated cells were mostly positive for the MSC markers CD73, CD166, and CD105, and minimally reacted with CD34 and CD45 (hematopoietic markers)...
  56. Varadi V, Bevier M, Grzybowska E, Johansson R, Enquist Olsson K, Henriksson R, et al. Genetic variation in ALCAM and other chromosomal instability genes in breast cancer survival. Breast Cancer Res Treat. 2012;131:311-9 pubmed publisher
    ..Two SNPs in the ALCAM gene associated with BC-specific survival. For rs1044243, the HR was 4.35 (95% CI 1.34-14...
  57. Fernández M, Ferragut F, Cárdenas Delgado V, Bracalente C, Bravo A, Cagnoni A, et al. Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells. Biochim Biophys Acta. 2016;1860:2255-68 pubmed publisher
    We previously demonstrated that the activated leukocyte cell adhesion molecule (ALCAM/CD166) can interact with galectin-8 (Gal-8) in endothelial cells...
  58. Chappell P, Garner L, Yan J, Metcalfe C, Hatherley D, Johnson S, et al. Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. Structure. 2015;23:1426-1436 pubmed publisher
    ..domain of CD6 binds the N-terminal immunoglobulin superfamily (IgSF) domain of another cell surface receptor, CD166, which also engages in homophilic interactions...
  59. Carbotti G, Orengo A, Mezzanzanica D, Bagnoli M, Brizzolara A, Emionite L, et al. Activated leukocyte cell adhesion molecule soluble form: a potential biomarker of epithelial ovarian cancer is increased in type II tumors. Int J Cancer. 2013;132:2597-605 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM) is involved in cell-cell interactions in cancer. Shedding of its ectodomain by the metalloprotease ADAM17/TACE generates a soluble form (sALCAM)...
  60. Ni C, Zhang Z, Zhu X, Liu Y, Qu D, Wu P, et al. Prognostic value of CD166 expression in cancers of the digestive system: a systematic review and meta-analysis. PLoS ONE. 2013;8:e70958 pubmed publisher
    ..Only articles containing CD166 antigen immunohistochemical staining in cancers of the digestive system were included,including pancreatic cancer, ..
  61. Zhang W, Zhan S, Geng C, Sun X, Erkan M, Kleeff J, et al. Activated leukocyte cell adhesion molecule regulates the interaction between pancreatic cancer cells and stellate cells. Mol Med Rep. 2016;14:3627-33 pubmed publisher
    Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a transmembrane glycoprotein that is involved in tumor progression and metastasis...
  62. Caminal M, Velez R, Rabanal R, Vivas D, Batlle Morera L, Aguirre M, et al. A reproducible method for the isolation and expansion of ovine mesenchymal stromal cells from bone marrow for use in regenerative medicine preclinical studies. J Tissue Eng Regen Med. 2017;11:3408-3416 pubmed publisher
    ..for isolation and expansion of fibroblastic-like, adherent ovine MSCs that express CD44, CD90, CD140a, CD105 and CD166, and display trilineage differentiation potential...
  63. Smedbakken L, Jensen J, Hallén J, Atar D, Januzzi J, Halvorsen B, et al. Activated leukocyte cell adhesion molecule and prognosis in acute ischemic stroke. Stroke. 2011;42:2453-8 pubmed publisher
    ..Activated leukocyte cell adhesion molecule (ALCAM) is upregulated during neuroinflammation; we investigated whether ALCAM concentrations are associated with long-..
  64. Allmendinger O, Trautmann K, Mittelbronn M, Waidelich J, Meyermann R, Tatagiba M, et al. Activated leukocyte cell adhesion molecule is expressed in neuroepithelial neoplasms and decreases with tumor malignancy, matrix metalloproteinase 2 expression, and absence of IDH1R132H mutation. Hum Pathol. 2012;43:1289-99 pubmed publisher
    ..In summary, our findings indicate that activated leukocyte adhesion molecule expression levels in gliomas are probably linked to other mechanisms than its supposed role as regulator of matrix metalloproteinase 2. ..
  65. Li L, Zhang Z, Ma T, Huo R. PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM. Mol Med Rep. 2016;14:521-8 pubmed publisher
    ..Liquid chromatography?mass spectrometry demonstrated that activated leukocyte cell adhesion molecule (ALCAM) may be a direct target of PRMT1, and the interaction was confirmed by co?immunoprecipitation...
  66. Witzel I, Schröder C, Muller V, Zander H, Tachezy M, Ihnen M, et al. Detection of activated leukocyte cell adhesion molecule in the serum of breast cancer patients and implications for prognosis. Oncology. 2012;82:305-12 pubmed publisher
    Conflicting results have been reported about activated leukocyte cell adhesion molecule (ALCAM) expression in breast cancer and its prognostic value. Little is known about the role of ALCAM levels in the serum of breast cancer patients...
  67. Hotaling J, Waggott D, Goldberg J, JARVIK G, Paterson A, Cleary P, et al. Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort. J Urol. 2012;188:514-20 pubmed publisher
    ..The nearest gene to these 2 single nucleotide polymorphisms is ALCAM. Genetic association results at these loci were similar on univariate and multivariate analysis...
  68. Ma L, Wang J, Lin J, Pan Q, Yu Y, Sun F. Cluster of differentiation 166 (CD166) regulated by phosphatidylinositide 3-Kinase (PI3K)/AKT signaling to exert its anti-apoptotic role via yes-associated protein (YAP) in liver cancer. J Biol Chem. 2014;289:6921-33 pubmed publisher
    Cluster of differentiation 166 (CD166 or Alcam) is a cell surface molecule that can be greatly induced in liver cancer cells after serum deprivation, suggesting its role in influencing cell survival...