albumin

Summary

Gene Symbol: albumin
Description: albumin
Alias: ANALBA, FDAH, PRO0883, PRO0903, PRO1341, albumin (32 AA), albumin (AA 34), cell growth inhibiting protein 42, growth-inhibiting protein 20
Species: human

Top Publications

  1. ncbi Characterization of the protein binding of chiral drugs by high-performance affinity chromatography. Interactions of R- and S-ibuprofen with human serum albumin
    D S Hage
    Department of Chemistry, University of Nebraska, Lincoln 68588-0304
    J Chromatogr A 693:23-32. 1995
  2. pmc Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters
    G Courtois
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Proc Natl Acad Sci U S A 85:7937-41. 1988
  3. pmc The modulation of inflammatory oedema by calcitonin gene-related peptide
    P Newbold
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 108:705-10. 1993
  4. ncbi Study of the enantioselective binding between BOF-4272 and serum albumins by means of high-performance frontal analysis
    A Shibukawa
    Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    J Chromatogr A 694:81-9. 1995
  5. ncbi Effects of glucose and an aldose reductase inhibitor on albumin permeation through a layer of cultured bovine vascular endothelial cells
    K Mimura
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Horm Metab Res 27:442-6. 1995
  6. ncbi Crystal structure of human serum albumin at 2.5 A resolution
    S Sugio
    Osaka Laboratories, Yoshitomi Pharmaceutical Industries Ltd, 2 25 1, Shodai Ohtani, Hirakata, Osaka 573 1153, Japan
    Protein Eng 12:439-46. 1999
  7. ncbi Atomic structure and chemistry of human serum albumin
    X M He
    Space Science Laboratory, Marshall Space Flight Center, Huntsville, Alabama 35812
    Nature 358:209-15. 1992
  8. ncbi Structural basis of the drug-binding specificity of human serum albumin
    Jamie Ghuman
    Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Mol Biol 353:38-52. 2005
  9. doi Structural basis of transport of lysophospholipids by human serum albumin
    Shihui Guo
    Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, People s Republic of China
    Biochem J 423:23-30. 2009
  10. pmc Structure, properties, and engineering of the major zinc binding site on human albumin
    Claudia A Blindauer
    Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    J Biol Chem 284:23116-24. 2009

Research Grants

  1. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
  2. Gonococcal resistance to peroxynitrite
    Virginia L Clark; Fiscal Year: 2010
  3. Alkylammonium Formate Mobile Phase Modifiers for Protein Liquid Chromatography
    NEIL DANIELSON; Fiscal Year: 2009
  4. Development of a Peptidomic Rapid Point-of-Care TB Diagnostic
    RAYMOND SAM NIEDBALA; Fiscal Year: 2013
  5. Contact site mapping of transient protein-protein complexes at the molecular leve
    Yumei Huang; Fiscal Year: 2012
  6. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
  7. Using natural antibodies to improve vaccines
    JOHN J IACOMINI; Fiscal Year: 2013
  8. ALCOHOL AND LIVER ENDOTHELIAL CELLS IN IMMUNE RESPONSES
    Geoffrey Thiele; Fiscal Year: 1999
  9. Protein Stabilization in Ionic Liquids
    Gloria Elliott; Fiscal Year: 2009
  10. CARHOHYDRATE MOIETIES OF GP120
    Khushi Matta; Fiscal Year: 1993

Detail Information

Publications303 found, 100 shown here

  1. ncbi Characterization of the protein binding of chiral drugs by high-performance affinity chromatography. Interactions of R- and S-ibuprofen with human serum albumin
    D S Hage
    Department of Chemistry, University of Nebraska, Lincoln 68588-0304
    J Chromatogr A 693:23-32. 1995
    ..were used to study the different binding characteristics of R- and S-ibuprofen with the protein human serum albumin (HSA)...
  2. pmc Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters
    G Courtois
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Proc Natl Acad Sci U S A 85:7937-41. 1988
    ..1 and demonstrate that it interacts with essential promoter regions of many liver-specific genes, including albumin, alpha-fetoprotein, and transthyretin...
  3. pmc The modulation of inflammatory oedema by calcitonin gene-related peptide
    P Newbold
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 108:705-10. 1993
    ..2. Oedema formation at intradermally-injected sites in the skin was measured by a 125I-labelled human serum albumin accumulation technique and paw oedema was measured by a weight displacement technique. 3...
  4. ncbi Study of the enantioselective binding between BOF-4272 and serum albumins by means of high-performance frontal analysis
    A Shibukawa
    Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    J Chromatogr A 694:81-9. 1995
    ..After the direct injection of a solution of 0.5-400 microM racemic BOF-4272 and 550 microM serum albumin onto the HPFA column, BOF-4272 was eluted, under a mild mobile phase condition (phosphate buffer, pH 7...
  5. ncbi Effects of glucose and an aldose reductase inhibitor on albumin permeation through a layer of cultured bovine vascular endothelial cells
    K Mimura
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Horm Metab Res 27:442-6. 1995
    ..ECs were derived from the intima of the thoracic aorta and permeability to nonglycated albumin, glycated albumin, and fluorescein dextrans (FDs) of molecular mass to albumin was measured...
  6. ncbi Crystal structure of human serum albumin at 2.5 A resolution
    S Sugio
    Osaka Laboratories, Yoshitomi Pharmaceutical Industries Ltd, 2 25 1, Shodai Ohtani, Hirakata, Osaka 573 1153, Japan
    Protein Eng 12:439-46. 1999
    A new triclinic crystal form of human serum albumin (HSA), derived either from pool plasma (pHSA) or from a Pichia pastoris expression system (rHSA), was obtained from polyethylene glycol 4000 solution...
  7. ncbi Atomic structure and chemistry of human serum albumin
    X M He
    Space Science Laboratory, Marshall Space Flight Center, Huntsville, Alabama 35812
    Nature 358:209-15. 1992
    The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule...
  8. ncbi Structural basis of the drug-binding specificity of human serum albumin
    Jamie Ghuman
    Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Mol Biol 353:38-52. 2005
    Human serum albumin (HSA) is an abundant plasma protein that binds a remarkably wide range of drugs, thereby restricting their free, active concentrations...
  9. doi Structural basis of transport of lysophospholipids by human serum albumin
    Shihui Guo
    Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, People s Republic of China
    Biochem J 423:23-30. 2009
    ..However, the transport mechanism of lysophospholipids in the extracellular space is unknown. HSA (human serum albumin) is the most abundant carrier protein in blood plasma and plays an important role in determining the absorption, ..
  10. pmc Structure, properties, and engineering of the major zinc binding site on human albumin
    Claudia A Blindauer
    Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    J Biol Chem 284:23116-24. 2009
    Most blood plasma zinc is bound to albumin, but the structure of the binding site has not been determined...
  11. ncbi HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment
    M Arese
    Institute for Cancer Research and Treatment and Department of Genetics, Biology and Biochemistry, School of Medicine, University of Torino, Candiolo Italy
    J Immunol 166:1380-8. 2001
    ..In vitro, Tat induced a dose-dependent flux of albumin through the EC monolayer that was inhibited by Ab anti-vascular VEGF receptor type 2 and WEB2170, and PAF ..
  12. ncbi Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites
    S Curry
    Blackett Laboratory, Imperial College, London, UK
    Nat Struct Biol 5:827-35. 1998
    Human serum albumin (HSA) is the most abundant protein in the circulatory system. Its principal function is to transport fatty acids, but it is also capable of binding a great variety of metabolites and drugs...
  13. doi A novel mutation in the albumin gene (c.1A>C) resulting in analbuminemia
    Gianluca Caridi
    Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini IRCCS, Genoa, Italy
    Eur J Clin Invest 43:72-8. 2013
    ..103600) is a rare autosomal recessive disorder manifested by the absence or severe reduction of circulating serum albumin in homozygous or compound heterozygous subjects...
  14. pmc Splicing mutation in human hereditary analbuminemia
    D E Ruffner
    Department of Biochemistry, University of California, Riverside 92521
    Proc Natl Acad Sci U S A 85:2125-9. 1988
    We have identified a structural defect in the serum albumin gene in human analbuminemia. Sequence determination of 1...
  15. doi Detection of a novel splicing mutation causing analbuminemia in a Libyan family
    Amina Bibi
    Biochemistry Laboratory, Children s Hospital, Bab Saadoun Square, 1007, Tunis, Tunisia
    Clin Biochem 45:1183-6. 2012
    Analbuminemia is a very rare autosomal recessive disorder. It is an allelic heterogeneous defect caused by a variety of mutations within the albumin gene. We describe in this report two new cases of analbuminemia in Libyans.
  16. doi Influence of electrostatic interactions on the fibrillation process of human serum albumin
    Josué Juárez
    Grupo de Fisica de Coloides y Polimeros, Departamento de Fisica de la Materia Condensada, Facultad de Fisica, Universidad de Santiago de Compostela, E 15782, Santiago de Compostela, Spain
    J Phys Chem B 113:10521-9. 2009
    The fibrillation propensity of the multidomain protein human serum albumin (HSA) has been analyzed under physiological and acidic conditions at room and elevated temperatures with varying ionic strengths by different spectroscopic ..
  17. doi Subdomain IB is the third major drug binding region of human serum albumin: toward the three-sites model
    Ferenc Zsila
    Laboratory of Chemical Pharmacology, Institute of Molecular Pharmacology, Research Centre for Natural Sciences, H 1025 Budapest, Pusztaszeri ut 59 67, Hungary
    Mol Pharm 10:1668-82. 2013
    According to the conventional view, noncovalent association of small molecules with human serum albumin (HSA) occurs principally at the so-called Sudlow's sites located in subdomain IIA and IIIA...
  18. pmc Structural mechanism of ring-opening reaction of glucose by human serum albumin
    Yu Wang
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
    J Biol Chem 288:15980-7. 2013
    ..Human albumin serum (HSA) is the most abundant protein in plasma and is glycated by glucose...
  19. pmc Elucidation of the binding mechanism of coumarin derivatives with human serum albumin
    Archit Garg
    Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad, India
    PLoS ONE 8:e63805. 2013
    ..Here, we studied the binding of synthesized coumarin derivatives with human serum albumin (HSA) at physiological pH 7...
  20. ncbi A novel splicing mutation causes an undescribed type of analbuminemia
    Monica Campagnoli
    Department of Biochemistry, A Castellani, Universita di Pavia, Italy
    Biochim Biophys Acta 1586:43-9. 2002
    ..is a rare autosomal recessive disorder manifested by the absence or severe reduction of circulating serum albumin in homozygous subjects...
  21. pmc A point mutation in the human serum albumin gene results in familial dysalbuminaemic hyperthyroxinaemia
    C E Petersen
    Department of Biochemistry and Biophysics, John A Burns School of Medicine, University of Hawaii, Honolulu 96822
    J Med Genet 31:355-9. 1994
    ..dysalbuminaemic hyperthyroxinaemia (FDH), exons 1-14 which span the entire coding region of the human serum albumin (HSA) gene were amplified by the polymerase chain reaction...
  22. ncbi Serum albumin predicts cardiac adverse events in patients with advanced atherosclerosis - interrelation with traditional cardiovascular risk factors
    Martin Schillinger
    Department of Angiology, Vienna General Hospital, Medical School, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Thromb Haemost 91:610-8. 2004
    Low serum albumin is a powerful predictor of cardiovascular adverse events in healthy subjects and patients with subclinical, atherosclerosis...
  23. ncbi A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred
    N Wada
    Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
    J Clin Endocrinol Metab 82:3246-50. 1997
    ..22-0.60). In the proband, the majority of [125I]T4 in serum T4-binding proteins was distributed in albumin fractions, and the isolated albumin had an increased affinity for T4...
  24. ncbi Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures
    A A Bhattacharya
    Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, London SW7 2BW, United Kingdom
    J Biol Chem 275:38731-8. 2000
    Human serum albumin (HSA) is one of the most abundant proteins in the circulatory system and plays a key role in the transport of fatty acids, metabolites, and drugs...
  25. ncbi Amyloid fibril formation and other aggregate species formed by human serum albumin association
    Pablo Taboada
    J Phys Chem B 110:20733-6. 2006
    ..Here, we report the formation of amyloid fibrils in the plasma protein human serum albumin under different in vitro conditions monitored using a combination of spectrophotometric and microscopic ..
  26. ncbi Structure of human serum albumin
    D C Carter
    Space Science Laboratory, NASA Marshall Space Flight Center, Huntsville, AL 35812
    Science 249:302-3. 1990
  27. pmc A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin
    Yu Wang
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China
    Protein Sci 20:2095-101. 2011
    ..DAUDA) is a dansyl-type fluorophore and has widely used as a probe to determine the binding site for human serum albumin (HSA)...
  28. ncbi Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect
    T Sunthornthepvarakul
    Department of Medicine, Rajavithi Hospital, Bangkok, Thailand
    J Clin Endocrinol Metab 83:1448-54. 1998
    We report the abnormal albumin in members of a Thai family that presented with high serum total T3 but not T4 when measured by radioimmunoassay. In contrast, total T3 values were very low when measured by ELISA and chemiluminescence...
  29. ncbi An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families
    T Sunthornthepvarakul
    Department of Medicine, University of Chicago, IL 60637
    Biochem Biophys Res Commun 202:781-7. 1994
    ..The entire coding region of the albumin gene of a subject with FDH was sequenced...
  30. pmc Ultrafast hydration dynamics in protein unfolding: human serum albumin
    J K Amisha Kamal
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 101:13411-6. 2004
    We report studies of unfolding and ultrafast hydration dynamics of the protein human serum albumin. Unique in this study is our ability to examine different domains of the same protein and the intermediate on the way to the unfolded ..
  31. ncbi Mechanism of anti-HIV activity of negatively charged albumins: biomolecular interaction with the HIV-1 envelope protein gp120
    M E Kuipers
    Section of Pharmacokinetics and Drug Delivery, University Center for Pharmacy, Groningen Institute for Drug Studies GIDS, The Netherlands
    J Acquir Immune Defic Syndr Hum Retrovirol 11:419-29. 1996
    ..In contrast, mannosylated albumin containing about 14 mannose groups showed an increased binding compared with native albumin...
  32. ncbi Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids
    I Petitpas
    Biophysics Section, Department of Biological Sciences, Blackett Laboratory, Imperial College of Science, Technology and Medicine, London SW7 2BW, UK
    J Mol Biol 314:955-60. 2001
    The primary ligands of human serum albumin (HSA), an abundant plasma protein, are non-esterified fatty acids. In vivo, the majority of fatty acids associated with the protein are unsaturated...
  33. ncbi Three-dimensional structure of human serum albumin
    D C Carter
    National Aeronautics and Space Administration, Space Sciences Laboratory, Marshall Space Flight Center, AL 35812
    Science 244:1195-8. 1989
    The three-dimensional structure of human serum albumin has been solved at 6.0 angstrom (A) resolution by the method of multiple isomorphous replacement...
  34. pmc A nucleotide insertion and frameshift cause analbuminemia in an Italian family
    S Watkins
    Department of Biology, Indiana University, Bloomington 47405
    Proc Natl Acad Sci U S A 91:2275-9. 1994
    In analbuminemia, a very rare inherited syndrome, subjects produce little or no albumin (1/100th to 1/1000th normal), presumably because of a mutation in the albumin gene; yet, they have only moderate edema and few related symptoms owing ..
  35. doi Mutations and polymorphisms of the gene of the major human blood protein, serum albumin
    Lorenzo Minchiotti
    Department of Biochemistry A Castellani, University of Pavia, Pavia, Italy
    Hum Mutat 29:1007-16. 2008
    We have tabulated the 77 currently known mutations of the familiar human blood protein, serum albumin (ALB). A total of 65 mutations result in bisalbuminemia...
  36. doi Location of the mutation site in the first two reported cases of analbuminemia
    Mary S Ruhoff
    Research Institute, The Mary Imogene Bassett Hospital affiliated with Columbia University, Cooperstown, NY 13326, USA
    Clin Biochem 43:525-7. 2010
    ..To find the mutation causing the first two reported cases of analbuminemia...
  37. ncbi Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4
    P P Minghetti
    J Biol Chem 261:6747-57. 1986
    The human albumin gene spans 16,961 nucleotides from the putative "Cap" site to the first poly(A) addition site...
  38. ncbi Retinol and retinoic acid bind human serum albumin: stability and structural features
    C N N'soukpoé-Kossi
    Department of Chemistry Biology, Universite du Quebec a Trois Rivieres, C P 500, Trois Rivieres, Quebec, Canada G9A 5H7
    Int J Biol Macromol 40:484-90. 2007
    ..Human serum albumin (HSA), as a transport protein, is the major target of several micronutrients in vivo...
  39. doi Temperature-dependent simultaneous ligand binding in human serum albumin
    Sudarson Sekhar Sinha
    Unit for Nano Science and Technology, Department of Chemical, Biological and Macromolecular Sciences, SN Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India
    J Phys Chem B 112:4884-91. 2008
    Human serum albumin (HSA) is a soluble protein in our circulatory system, which is known to bind a variety of drugs and ligands...
  40. ncbi The anti-apoptotic activity of albumin for endothelium is mediated by a partially cryptic protein domain and reduced by inhibitors of G-coupled protein and PI-3 kinase, but is independent of radical scavenging or bound lipid
    Christine Bolitho
    Cellular and Molecular Pathology Research Unit, Department of Oral Pathology and Oral Medicine, University of Sydney, Westmead Centre for Oral Health, Westmead, Australia
    J Vasc Res 44:313-24. 2007
    Increased vascular disease occurs with low albumin (human serum albumin, HSA), possibly reflecting specific inhibition of endothelial apoptosis reported for tissue culture...
  41. ncbi HIV-1 Tat reduces nephrin in human podocytes: a potential mechanism for enhanced glomerular permeability in HIV-associated nephropathy
    Sophie Doublier
    Department of Internal Medicine and Center of Experimental Research and Medical Sciences CERMS, University of Turin, Turin, Italy
    AIDS 21:423-32. 2007
    ..To determine whether HIV-1 Tat may directly alter glomerular permeability in HIV-associated nephropathy (HIVAN)...
  42. ncbi Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death
    Elizabeth T Gum
    Department of Neurology, San Francisco Veterans Affairs Medical Center and University of California at San Francisco, 94121, USA
    Stroke 35:590-5. 2004
    Studies using animal models of stroke have shown that human serum albumin (HSA) significantly ameliorates cerebral ischemic injury after both transient and permanent ischemia, even when administered after the onset of ischemia or ..
  43. ncbi NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification
    Mark J Howard
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, UK
    J Biol Chem 280:22582-9. 2005
    ..addressed this problem using a model helical peptide system containing a di-lysine motif derived from human serum albumin. We have shown that, in the presence of 50 mm glucose and at 37 degrees C, one of the lysine residues in the di-..
  44. ncbi Albumin prevents mitochondrial depolarization and apoptosis elicited by endoplasmic reticulum calcium depletion of neuroblastoma cells
    Sonia Gallego-Sandín
    Servicio de Farmacologia Clinica, Hospital Universitario de la Princesa, Madrid, Spain
    Eur J Pharmacol 520:1-11. 2005
    Serum albumin protects against cell death elicited by various cytotoxic agents; however, conflicting views on the protective mechanism still remain...
  45. ncbi Thermodynamic analysis of human serum albumin interactions with glucose: insights into the diabetic range of glucose concentration
    A Mohamadi-Nejad
    Institute of Biochemistry and Biophysics, University of Tehran, Iran
    Int J Biochem Cell Biol 34:1115-24. 2002
    ..Human serum albumin (HSA) interacts with glucose forming glycated HSA...
  46. ncbi Ischemia-modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery
    Majed A Refaai
    Division of Laboratory Medicine, Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, Saint Louis, MO 63110, United States
    Clin Chim Acta 366:264-8. 2006
    Ischemia can alter the ability of albumin to bind free metal atoms...
  47. ncbi HIV-1 Tat increases endothelial solute permeability through tyrosine kinase and mitogen-activated protein kinase-dependent pathways
    T Oshima
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport 71130 3932, USA
    AIDS 14:475-82. 2000
    ..The bases of these errors are not known, but might involve secretion of the HIV-1 derived transcription factor 'Tat-1'. This study investigated Tat-1 mediated endothelial barrier changes and second message regulation of this phenomenon...
  48. ncbi Bovine whey fractionation based on cation-exchange chromatography
    R Hahn
    Institute of Applied Microbiology, University of Agriculture, Forestry and Biotechnology, Vienna, Austria
    J Chromatogr A 795:277-87. 1998
    ..Compared to studies with standard proteins, such as 100 mg/ml bovine serum albumin for S-Hyper D, their binding capacities were very low...
  49. ncbi Covalent linkage of recombinant hirudin to a novel ionic poly(carbonate) urethane polymer with protein binding sites: determination of surface antithrombin activity
    M D Phaneuf
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Artif Organs 22:657-65. 1998
    ..The in vitro efficacy of thrombin inhibition by this novel biomaterial surface was then evaluated. Bovine serum albumin (BSA), which was selected as the basecoat protein, was reacted with sulfo-SMCC in a 1:50 molar ratio...
  50. ncbi Comparison of five methods for the study of drug-protein binding in affinity capillary electrophoresis
    M H Busch
    Amsterdam Institute of Molecular Studies, University of Amsterdam, Netherlands
    J Chromatogr A 777:311-28. 1997
    ..For the comparison of these five methods the warfarin-bovine serum albumin (BSA) system was used...
  51. ncbi Quantitative structure-activity relationships studies with micellar electrokinetic chromatography. Influence of surfactant type and mixed micelles on estimation of hydrophobicity and bioavailability
    S Yang
    North Carolina State University, Department of Chemistry, Raleigh 27695-8204, USA
    J Chromatogr A 721:323-35. 1996
    ..of biological activities [small intestinal absorption in the rat (log A/NA) and protein binding to human serum albumin (log B/F) were examined in this work...
  52. ncbi Binding of lead to collagen type I and V and alpha2(I) CNBr (3,5) fragment by a modified Hummel-Dreyer method
    I Miksik
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    J Chromatogr A 852:245-53. 1999
    ..The association constants obtained are comparable with the low affinity interactions seen e.g., between Cu and bovine serum albumin.
  53. ncbi C repeats of the streptococcal M1 protein achieve the human serum albumin binding ability by flanking regions which stabilize the coiled-coil conformation
    K Gubbe
    Institute of Experimental Microbiology, University of Jena, Winzerlaer Strasse 10, D-07745, Jena, Germany
    Biochemistry 36:8107-13. 1997
    ..the coiled-coil domain were studied by analyzing their secondary structures and binding affinities to human serum albumin (HSA). As shown by circular dichroism, all fragments are in an alpha-helical conformation...
  54. ncbi Adsorption and selectivity characteristics of several human serum proteins with immobilised hard Lewis metal ion-chelate adsorbents
    M Zachariou
    Centre for Bioprocess Technology, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Chromatogr A 890:95-116. 2000
    ..behaviour of four "marker" proteins, namely transferrin, alpha2-macroglobulin, gammaglobulin and human serum albumin have furthermore been employed to monitor the differences in protein selectivity exhibited by these IMAC systems...
  55. ncbi Nutritional support in patients with cancer of the esophagus: impact on nutritional status, patient compliance to therapy, and survival
    F Bozzetti
    Department of Surgery of the Gastrointestinal Tract, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 84:681-6. 1998
    ..unchanged levels of visceral proteins, while SD patients had a decrease in body weight, total proteins and serum albumin (P <0.01)...
  56. ncbi Role of binding capacity versus binding strength in the separation of chiral compounds on protein-based high-performance liquid chromatography columns. Interactions of D- and L-tryptophan with human serum albumin
    J Yang
    Department of Chemistry, University of Nebraska-Lincoln 68588-0304, USA
    J Chromatogr A 725:273-85. 1996
    ..It was concluded that varying such chromatographic conditions can alter either the binding strength or number of binding sites for solutes injected onto immobilized protein columns...
  57. pmc Pharmacological analysis of neutrophil chemotactic factor production by leucocytes and roles of PAF in allergic inflammation in rats
    M Watanabe
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Br J Pharmacol 111:123-30. 1994
    ..into the pouch fluid 8 h after injection of the antigen (azobenzenearsonate-conjugated acetyl bovine serum albumin) solution into the air pouch of immunized rats was inhibited dose-dependently by treatment with PAF antagonists (..
  58. pmc Peripheral GABAA receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation
    W S Lee
    Massachusetts General Hospital, Stroke and Neurovascular Regulation, Charlestown 02129, USA
    Br J Pharmacol 116:1661-7. 1995
    ..We tested the effects of sodium valproate and GABAA-agonist muscimol on dural plasma protein ([125I]-bovine serum albumin) extravasation evoked by either unilateral trigeminal ganglion stimulation (0...
  59. ncbi [Brain hypothermia treatment for the management of severe pediatric brain injury]
    N Hayashi
    Department of Emergency and Critical Care Medicine, Nihon University, Tokyo
    No To Hattatsu 32:122-31. 2000
    ..and replacement of L-arginine were most useful, as well as preconditioning for rewarming as follows: serum albumin > 3...
  60. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ..Accumulation of [125I]-human serum albumin within the synovial cavity was used as a marker of increased vascular permeability. 2...
  61. ncbi Protein binding on polyelectrolyte-treated glass. Effect of structure of adsorbed polyelectrolyte
    Y Wang
    Department of Chemistry, Indiana University-Purdue University, Indianapolis 46202-3274, USA
    J Chromatogr A 808:61-70. 1998
    ..We found that the selectivity of PDADMAC for bovine serum albumin vs...
  62. ncbi [Study on sepsis in the elderly at Nagoyashi-Koseiin Geriatric Hospital]
    T Yamamoto
    Department of Internal Medicine, Nagoyashi-Koseiin Geriatric Hospital
    Kansenshogaku Zasshi 69:1141-50. 1995
    ..6% were survivors, and 34.4% were nonsurvivors. At the onset of sepsis, weight, blood pressure, serum albumin, and total cholesterol in the nonsurvivors were significantly lower than those in the survivors, whereas heart ..
  63. ncbi Charge transfer chromatographic study of the binding of commercial pesticides to various albumins
    T Cserhati
    Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest, Hungary
    J Chromatogr A 699:285-90. 1995
    The interaction of 28 commercial pesticides with human and bovine serum albumin as well as with egg albumin was studied by charge-transfer reversed-phase thin-layer chromatography and the relative strength of the interaction was ..
  64. ncbi Localization and characterization of fibronectin-binding to group A streptococci. An electron microscopic study using protein-gold-complexes
    B Wagner
    Central Institute of Microbiology and Experimental Therapy, Academy of Sciences of the GDR, Jena
    Zentralbl Bakteriol Mikrobiol Hyg A 269:479-91. 1988
    ..Simultaneous labelling of the bacteria with marker complexes of FnF, human serum albumin and fibrinogen revealed separate receptor sites for each protein...
  65. ncbi [Clinical study on bacteremia in patients with liver cirrhosis]
    R Mizuno
    Department of Internal Medicine, Meijo Hospital, Nagoya, Japan
    Kansenshogaku Zasshi 70:456-62. 1996
    ..Laboratory data of cirrhotic patients showed that positive blood culture patients had significantly lower serum albumin, prothrombin time and hepaplastin test than negative patients...
  66. ncbi [Effects of angiotensin II and pressure on cellular fibronectin in the vascular wall in organotypic culture]
    N Bardy
    INSERM U141, , Paris
    Arch Mal Coeur Vaiss 87:991-5. 1994
    ..40 ml/min) in DME medium containing antibiotics, supplemented with 20% fetal calf serum or with 5% bovine serum albumin. In a series of experiments, angiotensin II (10(-6) M) and indomethacin (10(-5) M) were added to culture media...
  67. ncbi Studies on malabsorption in malnourished Pakistani children
    I Mazahir
    Department of Biochemistry, Jinnah Postgraduate Medical Centre, Karachi, Pakistan
    Z Naturforsch C 43:782-6. 1988
    ..Haemoglobin, total protein and serum albumin showed a decrease and the fall was greatest in PEM cases as compared with the control group...
  68. ncbi [Meningoencephalitis in Kawasaki disease]
    K Takagi
    First Department of Pediatrics, Toho University School of Medicine, Tokyo
    No To Hattatsu 22:429-35. 1990
    ..05) and hematocrit (P less than 0.05), serum total protein (P less than 0.01), and serum albumin levels (P less than 0.01) were also significantly lower...
  69. ncbi Effect of organic modifiers on retention and enantiomeric separations by capillary electrophoresis with human serum albumin as a chiral selector in solution
    A Ahmed
    Department of Oncology, McGill University, Montreal, Canada
    J Chromatogr A 766:237-44. 1997
    ..and enantiomeric separations of benzoin and propiomazine by capillary electrophoresis, using human serum albumin as a chiral selector. The effects of these modifiers on mobilities of analytes are rather difficult to interpret...
  70. ncbi Antibody to silicone and native macromolecules in women with silicone breast implants
    A Vojdani
    Immunosciences Laboratory, Inc, Beverly Hills, CA 90211
    Immunopharmacol Immunotoxicol 16:497-523. 1994
    ..samples were obtained and examined for the presence of Silicone antibodies, Myelin Basic Protein and human serum albumin antibodies. These samples were then compared to 520 matched controls without implants...
  71. ncbi Removal of endotoxins by affinity sorbents
    F B Anspach
    GBF-National Research Centre for Biotechnology, Braunschweig, Germany
    J Chromatogr A 711:81-92. 1995
    ..only low initial contamination levels (< 34 EU/ml) were reduced to tolerable levels from bovine serum albumin (BSA) as the negatively charged protein model owing to competition of BSA and endotoxins for adsorption sites...
  72. ncbi [Differences in susceptibility of Helicobacter pylori to macrolide and other antibiotics in tests using blood agar and albumin agar]
    E Ishii
    Department of Health and Epidemiology, Osaka City Institute of Public Health and Environmental Sciences
    Kansenshogaku Zasshi 67:137-42. 1993
    ..macrolides against Helicobacter pylori strains were determined on Brucella agar supplemented with bovine serum albumin fraction V (albumin agar) and compared with those on blood agar. MICs of the macrolides against H...
  73. ncbi Comparison of chromatographic ion-exchange resins. II. More strong anion-exchange resins
    A Staby
    Novo Nordisk A/S, Protein Purification, Gentofte, Denmark
    J Chromatogr A 908:149-61. 2001
    ..with five different proteins: anti-Factor VII monoclonal antibody (immunoglobulin G), aprotinin, bovine serum albumin, lipolase and myoglobin...
  74. ncbi Purification of protein and recycling of polymers in a new aqueous two-phase system using two thermoseparating polymers
    J Persson
    Department of Biochemistry, Lund University, Sweden
    J Chromatogr A 864:31-48. 1999
    ..The partitioning of three proteins, bovine serum albumin, lysozyme and apolipoprotein A-1, has been studied in the EO50PO50/HM-EOPO system and how the partitioning is ..
  75. ncbi The binding of 99mTc(Sn)-MDP complexes to human serum albumin and other blood proteins determined with gel chromatography and ultrafiltration
    Y M Huigen
    Analytical Chemistry Laboratory, State University of Utrecht, The Netherlands
    Int J Rad Appl Instrum A 40:629-35. 1989
    The binding of 99mTc(Sn)-MDP to human serum albumin and other blood proteins was investigated by gel chromatography and ultrafiltration...
  76. ncbi Quantitative analysis of aflatoxin-albumin adducts
    F Z Sheabar
    Division of Toxicology, Massachusetts Institute of Technology, Cambridge 02139
    Carcinogenesis 14:1203-8. 1993
    ..Serum albumin is quantitatively the most abundant target for aflatoxin B1 and the measurement of aflatoxin-serum albumin ..
  77. ncbi Effects of serum, its protein and lipid extracts, and commercial serum proteins and lipid on the isolated frog heart
    J Singh
    Department of Applied Biology, Lancashire Polytechnic, Preston, UK
    J Comp Physiol B 161:303-10. 1991
    ..containing a high proportion of immunoglobulins elicited large increases in contractile force, whereas serum albumin evoked a negative inotropic effect...
  78. ncbi [Relation between candidiasis and nutrition of patients and MRSA infection]
    S Takeda
    Second Department of Internal Medicine, Fukuoka University School of Medicine
    Kansenshogaku Zasshi 71:899-902. 1997
    ..96% g/dl in colonization group. Furthermore there were significance (p < 0.01) for mean serum albumin (mean) were 3.11 g/dl v.s. 3.27 g/dl...
  79. pmc Study of the effector mechanism involved in the production of haemorrhagic necrosis of the small intestine in rat passive anaphylaxis
    M I Pellón
    Departamento de Bioquímica y Fisiología Consejo Superior de Investigaciones Científicas, Facultad de Medicina, Valladolid, Spain
    Br J Pharmacol 112:1101-8. 1994
    ..6. PAF levels were transiently increased after dinitrophenol (DNP)- bovine serum albumin (BSA) challenge in the small intestine of IgE-sensitized rats. 7...
  80. ncbi The energetic cost of protein synthesis in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss)
    M C Pannevis
    Department of Zoology, University of Aberdeen, UK
    J Comp Physiol B 162:393-400. 1992
    ..The presence of bovine serum albumin was essential for the viability of isolated hepatocytes during isolation, but, in order to measure protein ..
  81. ncbi Relationship between nutritional status and tumor growth in humans
    F Bozzetti
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 81:1-6. 1995
    ..characterized according to nutritional status (percent of weight loss as compared to usual body weight, serum albumin, serum cholinesterase, number of lymphocytes) and rate of incorporation of 3H thymidine labelling index in the ..
  82. ncbi Isolation by gel-permeation chromatography of a non-covalent complex of Cibacron Blue F3G-A with human serum albumin
    A Compagnini
    Dipartimento di Scienze Chimiche, , Italy
    J Chromatogr A 736:115-23. 1996
    ..chromatography on Sephadex G-100 of a non-covalent complex of Cibacron Blue F3G-A (CB) with human serum albumin (HSA) is described...
  83. ncbi Aqueous two-phase systems containing self-associating block copolymers. Partitioning of hydrophilic and hydrophobic biomolecules
    M Svensson
    Department of Physical Chemistry 1, Lund University, Sweden
    J Chromatogr A 839:71-83. 1999
    ..The proteins were lysozyme, bovine serum albumin, cytochrome c, bacteriorhodopsin and the engineered B domain of staphylococcal protein A, named Z...
  84. ncbi Affinity chromatography of human estrogen receptor-alpha expressed in Saccharomyces cerevisiae. Combination of heparin- and 17beta-estradiol-affinity chromatography
    W Feng
    Institute for Applied Microbiology, University of Agricultural Sciences, Vienna, Austria
    J Chromatogr A 852:161-73. 1999
    ..purified 100-fold with ligand-affinity chromatography using 17beta-estradiol 17-hemisuccinate-bovine serum albumin-Sepharose. The receptor could be kept in its native state, although saturated with 17beta-estradiol...
  85. ncbi Immunogenicity and specificity of the candidate multi-epitope-vaccines against HIV-1
    Y Lu
    Research Center for Medical Science and Department of Biology, Tsinghua University, Ministry of Education, Beijing, PR China
    Immunopharmacol Immunotoxicol 23:487-94. 2001
    ..The two peptides were conjugated to carrier protein bovine serum albumin (BSA) and used for immunization of rabbits...
  86. ncbi [Improved prognosis of first episode HIV associated Pneumocystis carinii pneumonia without preventive treatment: etiology and sequelae]
    S Ewig

    Pneumologie 50:455-61. 1996
    ..The mean time until diagnosis of PCP was five days shorter in this group. Moreover, CD8 cell-count and serum albumin were found to be significantly higher, and mean loss of weight prior to diagnosis of PCP significantly lower...
  87. pmc Cutaneous permeability responses to bradykinin and histamine in the guinea-pig: possible differences in their mechanism of action
    W Paul
    Department of Pharmacology, King s College, London
    Br J Pharmacol 111:159-64. 1994
    ..in guinea-pig skin have been measured using accumulation of intravenously injected 125I-labelled human serum albumin (125I-HSA). 2. The nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 0...
  88. ncbi High-performance frontal analysis for the study of protein binding of troglitazone (CS-045) in albumin solution and in human plasma
    A Shibukawa
    Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    J Chromatogr A 697:337-43. 1995
    ..of the unbound concentration of troglitazone (CS-045), a new oral antidiabetic agent, in human serum albumin (HSA) solution and in human plasma...
  89. ncbi The influence of cell adsorbent interactions on protein adsorption in expanded beds
    H M Fernandez-Lahore
    Institut für Enzymtechnologie, Heinrich Heine Universitat Dusseldorf, Julich, Germany
    J Chromatogr A 873:195-208. 2000
    ..cerevisiae) on the adsorption of model proteins (hen egg white lysozyme and bovine serum albumin) to various stationary phases (cation and anion-exchange, hydrophobic interaction, immobilised metal affinity)...
  90. ncbi Tryptic peptide mapping of sequence 299-585 of human serum albumin by high-performance liquid chromatography and fast atom bombardment mass spectrometry
    S Fisichella
    Dipartimento di Scienze Chimiche, , Italy
    J Chromatogr A 693:33-44. 1995
    The determination of the tryptic peptide mapping of sequence 299-585 (cyanogen bromide fragment A) of human serum albumin (HSA) by chemical and enzymatic cleavages and combined use of HPLC and FAB-MS is described...
  91. ncbi Factors influencing wound healing after surgery for metastatic disease of the spine
    I B McPhee
    Division of Orthopaedic Surgery, University of Queensland, Brisbane, Australia
    Spine (Phila Pa 1976) 23:726-32; discussion 732-3. 1998
    ..Nutritional status was evaluated by determining serum protein and serum albumin concentrations and by total lymphocyte count. RESULTS: Wound breakdown and infection occurred in 15 of 75 wounds...
  92. ncbi Wound healing angiogenesis: indirect stimulation by basic fibroblast growth factor
    D R Knighton
    Department of Surgery, University of Minnesota, Minneapolis 55455
    J Trauma 30:S134-44. 1990
    ..Human serum albumin (HSA) (10 ng) and 50 ng of transforming growth factor-beta (TGF-beta) served as negative and positive controls...
  93. ncbi Micromorphometric evaluation of changes in symmetry of sarcoplasmic reticulum membranes induced by vanadate
    K Kranzhöfer
    Max Planck Institut fur medizinische Forschung, Abteilung Physiologie, Heidelberg, Bundesrepublik Deutschland
    Z Naturforsch C 47:762-72. 1992
    ..Removal of the membrane lipids by treating the vesicles with phospholipase A2 and bovine serum albumin diminishes the membrane surface by 50% resulting in a significant increase of both the membrane thickness and the ..
  94. ncbi The role of serum fructosamine as a screening test for gestational diabetes mellitus
    I Vermes
    Department of Clinical Chemistry, H. d. K. Hospital, Oldenzaal, The Netherlands
    Horm Metab Res 21:73-6. 1989
    The serum fructosamine concentration indicates the degree of glycation of serum proteins, particularly albumin, and reflects an average blood glucose level over the previous 1-3 weeks...
  95. ncbi High-performance capillary electrophoresis for characterization of hapten-protein conjugates used for production of antibodies against soyasaponin I
    H Frøkiaer
    Department of Biochemistry and Nutrition, Technical University of Denmark, Lyngby
    J Chromatogr A 680:437-45. 1994
    ..Soyasaponin I was coupled to Kunitz soybean trypsin inhibitor (KSTI) and bovine serum albumin. The degree of coupling was determined by high-performance capillary electrophoresis (HPCE)...
  96. ncbi Modeling and simulation of the dynamic behavior of monoliths. Effects of pore structure from pore network model analysis and comparison with columns packed with porous spherical particles
    A I Liapis
    Department of Chemical Engineering and Biochemical Processing Institute, University of Missouri-Rolla, 65409-1230, USA
    J Chromatogr A 865:13-25. 1999
    ..in this work is numerically solved in order to study the dynamic behavior of the adsorption of bovine serum albumin (BSA) in a monolith having skeletons of radius r(o) = 0.75x10(-6) m and through-pores having diameters of 1...
  97. pmc Mortality, symptoms, and functional impairment in late-life depression
    C M Callahan
    Regenstrief Institute for Health Care, Richard L. Roudebush VAMC and the Indiana University School of Medicine, Indianapolis 46202-2859, USA
    J Gen Intern Med 13:746-52. 1998
    ..In proportional hazards models, age, gender, race, history of smoking, serum albumin value, and an ideal body weight in the lowest 10% were significant correlates of time to death, but the baseline ..
  98. ncbi One-stage versus two-stage anterior and posterior spinal reconstruction in adults. Comparison of outcomes including nutritional status, complications rates, hospital costs, and other factors
    J Dick
    Twin Cities Scoliosis and Spine Center, University of Minnesota, Minneapolis
    Spine (Phila Pa 1976) 17:S310-6. 1992
    ..fusion were preoperatively assessed and at weekly intervals during their hospitalization for the following: serum albumin, transferrin, total lymphocyte count, skin anergy and anthropometric measurements...
  99. ncbi [Study on intractable factors in urinary tract infections--multiple regression analysis]
    A Yokoo
    Department of Urology, Sapporo Medical University, School of Medicine
    Kansenshogaku Zasshi 68:905-15. 1994
    ..lymphocyte count, diabetic or not, whether the patient underwent major operation within 1 week or not, and serum albumin value, an indicator of malnutrition, as compromised factors were analyzed by multiple regression analysis...
  100. ncbi Protein adsorption on novel acrylamido-based polymeric ion exchangers. II. Adsorption rates and column behavior
    A K Hunter
    Department of Chemical Engineering, University of Virginia, Charlottesville 22903-2442, USA
    J Chromatogr A 897:81-97. 2000
    Uptake kinetics and breakthrough behavior were determined for bovine serum albumin (BSA) and alpha-chymotrypsinogen (alphaCHY) in new polymeric ion-exchange media based on acrylamido monomers...
  101. ncbi Studies on the growth-stimulatory activity of pigeon milk--comparison and synergistic effects with serum
    L Bharathi
    Department of Biosciences, Mangalore University, Mangala Gangotri, India
    J Comp Physiol B 163:332-6. 1993
    ..cells was enhanced by the homogenates of pigeon milk in the presence of both fetal bovine serum and bovine serum albumin, although the response with fetal bovine serum was greater than that with bovine serum albumin...

Research Grants64

  1. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..Furthermore, we will use E2 (cell permeable) and E2 conjugated with BSA (bovine serum albumin;cell impermeable) to determine the contribution of nuclear vs...
  2. Gonococcal resistance to peroxynitrite
    Virginia L Clark; Fiscal Year: 2010
    ..oxidation of dihydrorhodamine and DNA, and the ability to remove nitro- groups from nitrated bovine serum albumin. Successful completion of this project will identify novel genes involved in resistance to peroxynitrite in the ..
  3. Alkylammonium Formate Mobile Phase Modifiers for Protein Liquid Chromatography
    NEIL DANIELSON; Fiscal Year: 2009
    ..can be used to study the tertiary and secondary structures of model proteins such as cytochrome c, bovine serum albumin, and lysozyme in these ionic liquids...
  4. Development of a Peptidomic Rapid Point-of-Care TB Diagnostic
    RAYMOND SAM NIEDBALA; Fiscal Year: 2013
    ..deTect focused on a subset of nine peptides, optimized methods for conjugating these peptides to bovine serum albumin (BSA), and demonstrated that the peptide-BSA conjugates resulted in significantly enhanced reactivity (compared ..
  5. Contact site mapping of transient protein-protein complexes at the molecular leve
    Yumei Huang; Fiscal Year: 2012
    ..using model peptides as substrates, (b) purification/enrichment methods will be developed using bovine serum albumin (BSA) with reversible linkage as a model system, (c) an oxLink" set will be synthesized, and (d) the MS ..
  6. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    ..as well as capacitation was regulated by the presence of cholesterol acceptors such as Bovine Serum Albumin (BSA) in the capacitation media...
  7. Using natural antibodies to improve vaccines
    JOHN J IACOMINI; Fiscal Year: 2013
    ..natural antibodies, to analyze whether conjugation of a poorly immunogenic antigen, such as bovine serum albumin (BSA), to 1Gal could affect its immunogenicity in vivo...
  8. ALCOHOL AND LIVER ENDOTHELIAL CELLS IN IMMUNE RESPONSES
    Geoffrey Thiele; Fiscal Year: 1999
    ..the effect of ethanol administration on RME by various scavenger receptors for; formaldehyde treated bovine serum albumin (f- Alb), nonenzymatically glycosylated bovine serum albumin (AGE-Alb), acetylated low density lipoproteins (A-..
  9. Protein Stabilization in Ionic Liquids
    Gloria Elliott; Fiscal Year: 2009
    ..Aim #2: To identify the most solubilizing ILs for cytochrome C, lysozyme, and bovine serum albumin from the subset of ILs prioritized in Aim #1...
  10. CARHOHYDRATE MOIETIES OF GP120
    Khushi Matta; Fiscal Year: 1993
    ..an aglycon which can serve as a bridge for attachment to high molecular weight substances such as bovine serum albumin. Complex structures containing mannose is one of our major interests in this program...
  11. Recombinant human serum albumin for use in cell culture media
    Ning Huang; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Plasma-derived human serum albumin (pHSA) or bovine serum albumin are commonly added to cell culture media used in cell culture-based vaccine and therapeutic production, because it ..
  12. MICROFABRICATED MICRONEEDLES FOR DRUG DELIVERY
    MARK PRAUSNITZ; Fiscal Year: 2001
    ..in vitro by up to five orders of magnitude for small molecules (calcein), macromolecules (insulin, bovine serum albumin) and nanospheres (100 nm diameter)...
  13. MICROFABRICATED MICRONEEDLES FOR DRUG DELIVERY
    MARK PRAUSNITZ; Fiscal Year: 2003
    ..in vitro by up to five orders of magnitude for small molecules (calcein), macromolecules (insulin, bovine serum albumin) and nanospheres (100 nm diameter)...
  14. Recombinant Human Serum Albumin for Use in Cell Culture
    Ning Huang; Fiscal Year: 2010
    Plasma-derived human serum albumin (pHSA) or bovine serum albumin are commonly added to cell culture media used in cell culture-based vaccine and therapeutic production, because it enhances cell growth and increases protein productivity...
  15. SELECTIVE STIMULATION OF CELL-MEDIATED CANCER IMMUNITY
    Robert Hunter; Fiscal Year: 1980
    Bovine serum albumin (BSA) heavily conjugated with a lipid (dodecanoic acid) selectively stimulates a type of cell-mediated immunity, delayed hypersensitivity (DTH) instead of the antibody responses usually produced by stimulation with ..
  16. Targeted Delivery of TFOs for Treatment of Liver Fibrosis
    Ram I Mahato; Fiscal Year: 2010
    ..gene promoter specific triplex forming oligonucleotides (TFOs) conjugated with mannose 6-phosphate-bovine serum albumin (M6P-BSA) via a disulfide bond...
  17. Assay for Monitoring Glycemic Control in Diabetics
    Ralph Ballerstadt; Fiscal Year: 2010
    ..g. hemoglobin HbA1c, IgM, IgG, serum albumin, and fibrinogen), followed by fluorescence detection using a microplate reader...
  18. Initiating Events in AMD: a mouse model for the human disease
    JOE GILBERT HOLLYFIELD; Fiscal Year: 2013
    ..To test this hypothesis we immunized normal mice with CEP-adducted mouse serum albumin (CEP-MSA)...
  19. Nanoparticles in the Human Placenta:Toxicokinetics
    RICHARD KERMIT MILLER; Fiscal Year: 2010
    ..Two proteins in particular, IgG and albumin, are selectively recognized and either transported (IgG) or catabolized (albumin) by the placenta...
  20. Proteome and Transcriptome Markers of Hypertension in Urine and Plasma Exosomes
    Kevin L Schey; Fiscal Year: 2010
    ..discovery in plasma samples is the well known dynamic range issue where highly abundant proteins such as serum albumin are 1010 times more abundant than the least concentrated, perhaps most important, marker proteins...
  21. The Comprehensive Discovery and Assay of the Human Proteome
    PAUL contact STROOBANT; Fiscal Year: 2010
    ..plasma proteins has been the approximately 10 orders of magnitude relative abundance difference between serum albumin (35-50 x 109 pg/ml) and low abundance proteins such as Interleukin-6 (0-5 pg/ml)...
  22. Improved Tools for Expression of Recombinant Genes in the Yeast Pichia pastoris
    JAMES MICHAEL CREGG; Fiscal Year: 2012
    ..with over five thousand publications on its use and at least two human biopharmaceuticals (human serum albumin and ecallantide) on the market in the US and others at various stages in the clinical trial pipeline...
  23. Universal Protein Carrier Scaffold for Small Molecules and Peptide Therapeutics
    DAVID IAN RABUKA; Fiscal Year: 2010
    ..Redwood Bioscience's aldehyde-tag technology can be applied to create modified human serum albumin proteins...
  24. Solid state synthesis and applications of oligo(phenylene-ethynes)
    Wei Chu Xu; Fiscal Year: 2010
    ..order to assess their potential utility, one oligomer will be conjugated to the drug- binding protein human serum albumin (HSA), and the interaction of the construct with typical drugs will be measured by observing changes in ..
  25. OVERALL HEMOCOMPATIBILITY PEO-FUNCTIONALIZED SILOXANES
    William Collins; Fiscal Year: 2003
    ..Fibrinogen and vitronectin will be isolated from citrated human blood plasma. Human serum albumin will be used as a control...
  26. OVERALL HEMOCOMPATIBILITY PEO-FUNCTIONALIZED SILOXANES
    William Collins; Fiscal Year: 2001
    ..Fibrinogen and vitronectin will be isolated from citrated human blood plasma. Human serum albumin will be used as a control...
  27. Molecular Combinatorial Therapy of Glioblastoma Multiforme
    Waldemar Debinski; Fiscal Year: 2013
    ..to recombinant cytotoxins'delivery to GBM, it was demonstrated that using gadolinium and labeled human serum albumin (HSA) a faithful monitoring of drug distribution through CED can be obtained...
  28. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human serum albumin is capable of binding bilirubin with high affinity, thus sequestering it and mitigat- ing its harmful neurological effects in jaundiced newborns...
  29. Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
    Jeffrey K Griffiths; Fiscal Year: 2013
    ..grown in vitro. Nutritional status will be gauged via anthropometrics, hemoglobin, and serum albumin. HIV testing, if consented to, will be performed. Sputum isolates of Cr. will be speciated via RFLP analysis...
  30. Health Information Technology for Chronic Kidney Disease Management
    Lipika Samal; Fiscal Year: 2013
    ..al.;Specific Aim 1a: Develop a search method to find existing urine albumin to creatinine ratio, serum calcium, serum phosphate, serum albumin, and serum bicarbonate values...
  31. Integrating plasma IGF-1 into novel classification of hepatocellular carcinoma
    Ahmed Kaseb; Fiscal Year: 2013
    ..three objective laboratory-based parameters that assess the synthetic function of the liver through serum albumin level and prothrombin time or the elimination function of the liver through measuring serum bilirubin level, in ..
  32. Development of Human Asparaginase for Cancer Therapy
    Arnon Lavie; Fiscal Year: 2013
    ..An additional novel aspect of Aim 2 is the linking f the human asparaginase to human serum albumin (HSA)...
  33. A NOVEL STRATEGY FOR THE TREATMENT OF MELANOMA
    Mai Xu; Fiscal Year: 2013
    ..using hyperthermia to modulate the delivery of the FDA approved anticancer drug Abraxane (human serum albumin (HSA) based paclitaxel-nanoparticle) to tumors...
  34. TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis
    Daniela Kaufer; Fiscal Year: 2012
    ..to the development of focal epileptiform activity, similar to that observed following injury, and that serum albumin is a critical factor in subsequent epileptogenesis...
  35. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2013
    ..bilirubin is a measure of the capacity to sequester bilirubin in the blood compartment by its binding to serum albumin. The concentration of unbound bilirubin, the driver for bilirubin escaping from the vasculature, can be ..
  36. Development of sEphB4-HSA as Novel Therapeutic in Cancer
    VALERY G KRASNOPEROV; Fiscal Year: 2013
    ..We have developed an EphB4-EphrinB2 inhibitor - the extracellular fragment of EphB4 fused with human serum albumin (sEphB4-HSA)...
  37. Biological Response Indicators of Environment Stress Centers
    STEPHEN MORRIS RAPPAPORT; Fiscal Year: 2011
    ..We propose to enrich unknown cysteinyl adducts of human serum albumin and then to profile these adducts in the serum of lymphoma cases and controls...
  38. Obesity and Surgical Outcomes
    Jeffrey H Silber; Fiscal Year: 2010
    ..1) a three state, 50 hospital, Medicare "augmented claims analysis" that includes height, weight, and serum albumin information from charts (N=20,000), and (2) a nested, detailed chart abstraction (N=4000) using a matched cohort ..
  39. Nephrotic Syndrome, Cardiovascular Disease Risk and the Effect of Statin Therapy
    Laura H Mariani; Fiscal Year: 2012
    ..The syndrome is characterized by significant proteinuria, low serum albumin, edema and hyperlipidemia. Cardiovascular disease is the major morbidity for patients with chronic kidney disease...
  40. Development of At-211-Labeled Reagents for Therapy of Metastatic Prostate Cancer
    DANIEL SCOTT WILBUR; Fiscal Year: 2013
    ..In specific aim 3, the same molecules used in SA1 and SA2 will be conjugated with recombinant human serum albumin (rHSA) to provide 211At-labeled reagents that will be excluded from kidney, but will also have low immunogenicity...
  41. Altered synaptogenesis after albumin exposure: A model for post traumatic epilep
    Lydia J Wood; Fiscal Year: 2012
    ..It is already known that central nervous system exposure to serum albumin via a penetrating head injury can lead to downstream perilesional hyperxcitability and seizures...
  42. Building Disease Prediction Models by Synthesis Analysis
    XIAO HUA A ZHOU; Fiscal Year: 2010
    ..Therefore, new risk factors such as serum albumin, homocysteine, C-reactive protein...
  43. Neuroprotection by Docosahexaenoic Acid-Albumin in Experimental Stroke
    Ludmila S Belayev; Fiscal Year: 2013
    ..substantial advances in neuroprotection for ischemic stroke by establishing that moderate- to high- dose human albumin administration is a potent neuroprotective therapy in ischemic stroke-a therapy currently in clinical trial...
  44. Nanoplatform-based combinational therapy against breast cancer
    Jin Xie; Fiscal Year: 2013
    ..to meet the challenge through a nanoplatform that we recently developed, which is comprised of a human serum albumin (HSA) coating, an amine-rich intermediate coating, and an iron oxide nanoparticle (lONP) core...
  45. COMPETITION FOR HEME AMONG PERIODONTAL BACTERIA
    GEOFFREY TOMPKINS; Fiscal Year: 1993
    ..The assay will be modified to examine the influence of the specific heme- binding proteins, human serum albumin and human hemopexin, on bacterial heme-acquisition...
  46. Retrospective Cyanide Assay from a Unique HSA-CN Adduct
    Kenneth M Aldous; Fiscal Year: 2010
    ..by us showed that CN reacts with several susceptible disulfide bonds in immunoglobulin (IgG) and human serum albumin (HSA) to form SCN adducts on one of the Cys components...
  47. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY SAKHRANI; Fiscal Year: 2009
    ..The proteins selected for this study are human serum albumin, human IgG, insulin, and abatecept (monoclonal antibody by Bristol Myers Squibb)...
  48. Biomarkers for exposure to Stachybotrys
    Dorr Dearborn; Fiscal Year: 2007
    ..G, a macrocyclic trichothecene from Stachybotrys with 2 epoxides, forms stable adducts with human serum albumin. This offers the potential for quantitative biomarker 'dosimeters' in the form of protein adducts and ..
  49. CONTROL OF HUMAN MUSCLE CELL GROWTH AND DIFFERENTIATION
    RICHARD HAM; Fiscal Year: 1991
    ..optimize nutrient medium MCDB 120 plus epidermal growth factor (EGF), dexamethasone, insulin, fetuin, and serum albumin, will be used as the starting point for these studies...
  50. ACID/BASE TRANSPORT THROUGH LIPID BILAYER MEMBRANES
    JOHN GUTKNECHT; Fiscal Year: 1993
    ..the pH dependence, the voltage dependence, the dependence upon membrane thickness and the effects of serum albumin. The data from both groups of experiments will be used to predict proton conductances and weak acid transport ..
  51. EFFECTS OF AGING ON DELAYED HYPERSENSITIVITY IN MICE
    ALFRED CROWLE; Fiscal Year: 1980
    A/Jax female mice have been immunized with chicken conalbumin or methylated human serum albumin in Freund adjuvant at three-month intervals in a two-year period of aging (to 1...
  52. PH CONTROL OF PROTEIN SYNTHESIS
    Peter Garlick; Fiscal Year: 2003
    ..and respiratory acidosis are associated with depressed rates of synthesis of skeletal muscle protein and serum albumin. The purpose of the present proposal is therefore to characterize the relationship between protein synthesis ..
  53. HEPATIC PATHWAYS OF HEME AND BILIRUBIN METABOLISM
    John Gollan; Fiscal Year: 1999
    ..to the bLPM, the contribution of circulating lipid assemblies (HDL, LDL, erythrocyte membranes) and serum albumin will be investigated. The kinetics of intermembrane (bLPM to E.R...
  54. Assessing Functional Outcomes in Adolescent with ESRD
    Susan Furth; Fiscal Year: 2002
    ..Furth to examine the link between clinical measures such as hematocrit, serum albumin, and dialysis adequacy (Kt/V) and functional outcome/HRQL...
  55. IMMUNOTOXICITY OF ACID ANHYDRIDES IN THE LUNG
    JEAN REGAL; Fiscal Year: 1999
    ..will be sensitized ID with TMA and 3 wk later challenged intratracheally with antigen (TMA coupled to serum albumin)...
  56. Benzo[i]phenanthridines: TOP1-Targeting Antitumor Agents
    EDMOND LAVOIE; Fiscal Year: 2006
    ..of this alkaloid, the metabolic instability of its lactone moiety and the high binding affinity to human serum albumin of its hydrolysis product are among the obstacles that hampered clinical development of this first generation of ..
  57. CHEMICALLLY INDUCED CHRONIC ALLERGIC LUNG DISEASE
    MERYL KAROL; Fiscal Year: 2000
    ..Specific Aim 1 is to identify the in vitro chemical adducts and adduction sites of TDI on serum albumin (SA), and on hemoglobin (Hb), two proteins which in guinea pigs have been shown to bear adduct following ..
  58. MIMICS OF SUPEROXIDE DISMUTASE--ISOLATION & SYNTHESIS
    Irwin Fridovich; Fiscal Year: 1990
    ..systems, they are of little use in biological systems because a variety of proteins, including serum albumin, can strip them of their Cu(II) and thus inactivate them...
  59. MORTALITY & MORBIDITY IN HEMODIALYSIS PATIENTS
    John Daugirdas; Fiscal Year: 2001
    ..cardiovascular disease, infection, or other non-access-related causes, declining body weight, or declining serum albumin level) in patients randomly assigned to one of four groups: (A) moderate-dose dialysis, low-flux cellulose ..
  60. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006
    ..cells after the appearance of antigen-specific mlg or diffuse large cell lymphoma (DLCL) from DNP-human serum albumin (DNP-HSA)- or hen egg lysozyme (HEL)-immunized C57/BL/6 mice...
  61. NOVEL CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
    Brian Gray; Fiscal Year: 1999
    ..Binding of magnetically active small molecules to human serum albumin (HSA) through interaction of alkyl "tails" with binding sites on HSA should allow tailoring of blood pool half-..
  62. IMMUNOPATHOGEN. OF OCCUP. DIS. DUE TO REACT. CHEMICALS
    David Bernstein; Fiscal Year: 1991
    ..Only a minority of such cases have been associated with IgE responses to diisocyanate human serum albumin (HSA) conjugates...
  63. HYPOTHALAMIC OPIATES IN OBESITY-ACCELERATED HYPERTENSION
    Robin Rockhold; Fiscal Year: 1991
    ..hypertension will be identified by measuring alterations in plasma volume (radio-iodinated serum albumin dilution) and baroreflex sensitivity in conscious, unrestrained rats following chronic (2 month) changes in diet...
  64. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..predictor of death in ESRD, the cause of hypoalbuminemia in these patients is supplements do not increase albumin levels and intravenous amino acids are only partially and inconsistently beneficial...