albumin

Summary

Gene Symbol: albumin
Description: albumin
Alias: HSA, PRO0883, PRO0903, PRO1341, serum albumin
Species: human
Products:     albumin

Top Publications

  1. Blindauer C, Harvey I, Bunyan K, Stewart A, Sleep D, Harrison D, et al. Structure, properties, and engineering of the major zinc binding site on human albumin. J Biol Chem. 2009;284:23116-24 pubmed publisher
    Most blood plasma zinc is bound to albumin, but the structure of the binding site has not been determined...
  2. N soukpoé Kossi C, Sedaghat Herati R, Ragi C, Hotchandani S, Tajmir Riahi H. Retinol and retinoic acid bind human serum albumin: stability and structural features. Int J Biol Macromol. 2007;40:484-90 pubmed
    ..Human serum albumin (HSA), as a transport protein, is the major target of several micronutrients in vivo...
  3. Carter D, He X. Structure of human serum albumin. Science. 1990;249:302-3 pubmed
  4. Carter D, He X, Munson S, Twigg P, Gernert K, Broom M, et al. Three-dimensional structure of human serum albumin. Science. 1989;244:1195-8 pubmed
    The three-dimensional structure of human serum albumin has been solved at 6.0 angstrom (A) resolution by the method of multiple isomorphous replacement...
  5. He X, Carter D. Atomic structure and chemistry of human serum albumin. Nature. 1992;358:209-15 pubmed
    The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule...
  6. Ruhoff M, Greene M, Peters T. Location of the mutation site in the first two reported cases of analbuminemia. Clin Biochem. 2010;43:525-7 pubmed publisher
    ..DNA was extracted from blocks of fixed embedded liver. Exons of the albumin gene were amplified and sequenced...
  7. Sunthornthepvarakul T, Angkeow P, Weiss R, Hayashi Y, Refetoff S. An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. Biochem Biophys Res Commun. 1994;202:781-7 pubmed
    ..The entire coding region of the albumin gene of a subject with FDH was sequenced...
  8. Kamal J, Zhao L, Zewail A. Ultrafast hydration dynamics in protein unfolding: human serum albumin. Proc Natl Acad Sci U S A. 2004;101:13411-6 pubmed
    We report studies of unfolding and ultrafast hydration dynamics of the protein human serum albumin. Unique in this study is our ability to examine different domains of the same protein and the intermediate on the way to the unfolded ..
  9. Wang Y, Luo Z, Shi X, Wang H, Nie L, Huang M. A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin. Protein Sci. 2011;20:2095-101 pubmed publisher
    ..DAUDA) is a dansyl-type fluorophore and has widely used as a probe to determine the binding site for human serum albumin (HSA)...

More Information

Publications82

  1. Sinha S, Mitra R, Pal S. Temperature-dependent simultaneous ligand binding in human serum albumin. J Phys Chem B. 2008;112:4884-91 pubmed publisher
    Human serum albumin (HSA) is a soluble protein in our circulatory system, which is known to bind a variety of drugs and ligands...
  2. Bhattacharya A, Curry S, Franks N. Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J Biol Chem. 2000;275:38731-8 pubmed
    Human serum albumin (HSA) is one of the most abundant proteins in the circulatory system and plays a key role in the transport of fatty acids, metabolites, and drugs...
  3. Ruffner D, Dugaiczyk A. Splicing mutation in human hereditary analbuminemia. Proc Natl Acad Sci U S A. 1988;85:2125-9 pubmed
    We have identified a structural defect in the serum albumin gene in human analbuminemia. Sequence determination of 1...
  4. Ha C, Bhagavan N. Novel insights into the pleiotropic effects of human serum albumin in health and disease. Biochim Biophys Acta. 2013;1830:5486-93 pubmed publisher
    Human serum albumin is the principal protein in human serum. It participates in regulation of plasma oncotic pressure and transports endogenous and exogenous ligands such as thyroxine, free fatty acids, bilirubin, and various drugs...
  5. Juárez J, López S, Cambón A, Taboada P, Mosquera V. Influence of electrostatic interactions on the fibrillation process of human serum albumin. J Phys Chem B. 2009;113:10521-9 pubmed publisher
    The fibrillation propensity of the multidomain protein human serum albumin (HSA) has been analyzed under physiological and acidic conditions at room and elevated temperatures with varying ionic strengths by different spectroscopic ..
  6. Howard M, Smales C. NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification. J Biol Chem. 2005;280:22582-9 pubmed
    ..addressed this problem using a model helical peptide system containing a di-lysine motif derived from human serum albumin. We have shown that, in the presence of 50 mm glucose and at 37 degrees C, one of the lysine residues in the ..
  7. Minghetti P, Ruffner D, Kuang W, Dennison O, Hawkins J, Beattie W, et al. Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4. J Biol Chem. 1986;261:6747-57 pubmed
    The human albumin gene spans 16,961 nucleotides from the putative "Cap" site to the first poly(A) addition site...
  8. Petitpas I, Grune T, Bhattacharya A, Curry S. Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. J Mol Biol. 2001;314:955-60 pubmed
    The primary ligands of human serum albumin (HSA), an abundant plasma protein, are non-esterified fatty acids. In vivo, the majority of fatty acids associated with the protein are unsaturated...
  9. Bibi A, Jouini L, Sahli C, Hadj Fredj S, Abidi K, Gharsallah L, et al. Detection of a novel splicing mutation causing analbuminemia in a Libyan family. Clin Biochem. 2012;45:1183-6 pubmed publisher
    ..We describe in this report two new cases of analbuminemia in Libyans. The 14 coding exons of the human serum albumin (HSA) gene and their intron-exon junctions were PCR amplified...
  10. Petersen C, Scottolini A, Cody L, Mandel M, Reimer N, Bhagavan N. A point mutation in the human serum albumin gene results in familial dysalbuminaemic hyperthyroxinaemia. J Med Genet. 1994;31:355-9 pubmed
    ..familial dysalbuminaemic hyperthyroxinaemia (FDH), exons 1-14 which span the entire coding region of the human serum albumin (HSA) gene were amplified by the polymerase chain reaction...
  11. Caridi G, Dagnino M, Lugani F, Shalev S, Campagnoli M, Galliano M, et al. A novel mutation in the albumin gene (c.1A>C) resulting in analbuminemia. Eur J Clin Invest. 2013;43:72-8 pubmed publisher
    ..103600) is a rare autosomal recessive disorder manifested by the absence or severe reduction of circulating serum albumin in homozygous or compound heterozygous subjects...
  12. Sunthornthepvarakul T, Likitmaskul S, Ngowngarmratana S, Angsusingha K, Kitvitayasak S, Scherberg N, et al. Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect. J Clin Endocrinol Metab. 1998;83:1448-54 pubmed
    ..T3-binding studies showed that the association constant of serum albumin in affected subjects was 1.5 x 10(6) M-1 or 40-fold that of unaffected relatives of 3.9 x 10(4) M-1...
  13. Watkins S, Madison J, Galliano M, Minchiotti L, Putnam F. A nucleotide insertion and frameshift cause analbuminemia in an Italian family. Proc Natl Acad Sci U S A. 1994;91:2275-9 pubmed
    ..The mother was homozygous for the trait and had a serum albumin value of < 0...
  14. Wada N, Chiba H, Shimizu C, Kijima H, Kubo M, Koike T. A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. J Clin Endocrinol Metab. 1997;82:3246-50 pubmed
    ..22-0.60). In the proband, the majority of [125I]T4 in serum T4-binding proteins was distributed in albumin fractions, and the isolated albumin had an increased affinity for T4...
  15. Yang F, Bian C, Zhu L, Zhao G, Huang Z, Huang M. Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin. J Struct Biol. 2007;157:348-55 pubmed
    Human serum albumin (HSA) is the most abundant plasma protein in the human body with a plasma concentration of 0.6mM. HSA plays an important role in drug transport and metabolism...
  16. Zsila F. Subdomain IB is the third major drug binding region of human serum albumin: toward the three-sites model. Mol Pharm. 2013;10:1668-82 pubmed publisher
    According to the conventional view, noncovalent association of small molecules with human serum albumin (HSA) occurs principally at the so-called Sudlow's sites located in subdomain IIA and IIIA...
  17. Minchiotti L, Galliano M, Kragh Hansen U, Peters T. Mutations and polymorphisms of the gene of the major human blood protein, serum albumin. Hum Mutat. 2008;29:1007-16 pubmed publisher
    We have tabulated the 77 currently known mutations of the familiar human blood protein, serum albumin (ALB). A total of 65 mutations result in bisalbuminemia...
  18. Taboada P, Barbosa S, Castro E, Mosquera V. Amyloid fibril formation and other aggregate species formed by human serum albumin association. J Phys Chem B. 2006;110:20733-6 pubmed
    ..Here, we report the formation of amyloid fibrils in the plasma protein human serum albumin under different in vitro conditions monitored using a combination of spectrophotometric and microscopic ..
  19. Refaai M, Wright R, Parvin C, Gronowski A, Scott M, Eby C. Ischemia-modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery. Clin Chim Acta. 2006;366:264-8 pubmed
    Ischemia can alter the ability of albumin to bind free metal atoms...
  20. Gum E, Swanson R, Alano C, Liu J, Hong S, Weinstein P, et al. Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death. Stroke. 2004;35:590-5 pubmed
    Studies using animal models of stroke have shown that human serum albumin (HSA) significantly ameliorates cerebral ischemic injury after both transient and permanent ischemia, even when administered after the onset of ischemia or ..
  21. Roche M, Rondeau P, Singh N, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett. 2008;582:1783-7 pubmed publisher
    ..Glycation and oxidative damage cause protein modifications, frequently observed in numerous diseases. Albumin represents a very abundant and important circulating antioxidant...
  22. Duarte M, Rocha J, Moresco R, Duarte T, da Cruz I, Loro V, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clin Biochem. 2009;42:666-71 pubmed publisher
    The aim of this study was to evaluate the association between ischemia-modified albumin (IMA), lipids and inflammation biomarkers in patients with hypercholesterolemia, and the possible involvement of IMA in atheromatous plaque ..
  23. Schillinger M, Exner M, Mlekusch W, Amighi J, Sabeti S, Schlager O, et al. Serum albumin predicts cardiac adverse events in patients with advanced atherosclerosis - interrelation with traditional cardiovascular risk factors. Thromb Haemost. 2004;91:610-8 pubmed
    Low serum albumin is a powerful predictor of cardiovascular adverse events in healthy subjects and patients with subclinical, atherosclerosis...
  24. Campagnoli M, Rossi A, Palmqvist L, Flisberg A, Niklasson A, Minchotti L, et al. A novel splicing mutation causes an undescribed type of analbuminemia. Biochim Biophys Acta. 2002;1586:43-9 pubmed
    ..is a rare autosomal recessive disorder manifested by the absence or severe reduction of circulating serum albumin in homozygous subjects...
  25. Bolitho C, Bayl P, Hou J, Lynch G, Hassel A, Wall A, et al. The anti-apoptotic activity of albumin for endothelium is mediated by a partially cryptic protein domain and reduced by inhibitors of G-coupled protein and PI-3 kinase, but is independent of radical scavenging or bound lipid. J Vasc Res. 2007;44:313-24 pubmed
    Increased vascular disease occurs with low albumin (human serum albumin, HSA), possibly reflecting specific inhibition of endothelial apoptosis reported for tissue culture...
  26. Ghuman J, Zunszain P, Petitpas I, Bhattacharya A, Otagiri M, Curry S. Structural basis of the drug-binding specificity of human serum albumin. J Mol Biol. 2005;353:38-52 pubmed
    Human serum albumin (HSA) is an abundant plasma protein that binds a remarkably wide range of drugs, thereby restricting their free, active concentrations...
  27. Gallego Sandín S, Novalbos J, Rosado A, Cano Abad M, Arias E, Abad Santos F, et al. Albumin prevents mitochondrial depolarization and apoptosis elicited by endoplasmic reticulum calcium depletion of neuroblastoma cells. Eur J Pharmacol. 2005;520:1-11 pubmed
    b>Serum albumin protects against cell death elicited by various cytotoxic agents; however, conflicting views on the protective mechanism still remain...
  28. Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K. Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng. 1999;12:439-46 pubmed
    A new triclinic crystal form of human serum albumin (HSA), derived either from pool plasma (pHSA) or from a Pichia pastoris expression system (rHSA), was obtained from polyethylene glycol 4000 solution...
  29. Curry S, Mandelkow H, Brick P, Franks N. Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat Struct Biol. 1998;5:827-35 pubmed
    Human serum albumin (HSA) is the most abundant protein in the circulatory system. Its principal function is to transport fatty acids, but it is also capable of binding a great variety of metabolites and drugs...
  30. Wang Y, Yu H, Shi X, Luo Z, Lin D, Huang M. Structural mechanism of ring-opening reaction of glucose by human serum albumin. J Biol Chem. 2013;288:15980-7 pubmed publisher
    ..Human albumin serum (HSA) is the most abundant protein in plasma and is glycated by glucose...
  31. Garg A, Manidhar D, Gokara M, Malleda C, Suresh Reddy C, Subramanyam R. Elucidation of the binding mechanism of coumarin derivatives with human serum albumin. PLoS ONE. 2013;8:e63805 pubmed publisher
    ..Here, we studied the binding of synthesized coumarin derivatives with human serum albumin (HSA) at physiological pH 7...
  32. Guo S, Shi X, Yang F, Chen L, Meehan E, Bian C, et al. Structural basis of transport of lysophospholipids by human serum albumin. Biochem J. 2009;423:23-30 pubmed publisher
    ..However, the transport mechanism of lysophospholipids in the extracellular space is unknown. HSA (human serum albumin) is the most abundant carrier protein in blood plasma and plays an important role in determining the ..
  33. Mohamadi Nejad A, Moosavi Movahedi A, Hakimelahi G, Sheibani N. Thermodynamic analysis of human serum albumin interactions with glucose: insights into the diabetic range of glucose concentration. Int J Biochem Cell Biol. 2002;34:1115-24 pubmed
    ..Human serum albumin (HSA) interacts with glucose forming glycated HSA...
  34. Satish L, Millan S, Sasidharan V, Sahoo H. Molecular level insight into the effect of triethyloctylammonium bromide on the structure, thermal stability, and activity of Bovine serum albumin. Int J Biol Macromol. 2018;107:186-193 pubmed publisher
    ..the influence of triethyloctylammonium bromide on the structure, stability, and activity of Bovine Serum Albumin (BSA) using different spectroscopic methods Fluorescence and circular dichroism measurements revealed that BSA ..
  35. Das A, Basak P, Pattanayak R, Kar T, Majumder R, Pal D, et al. Trehalose induced structural modulation of Bovine Serum Albumin at ambient temperature. Int J Biol Macromol. 2017;105:645-655 pubmed publisher
    ..The results are in unison with the preferential exclusion and vitrification models to explain protein stabilization by trehalose and also points at the structure-function trade-off of proteins in presence of trehalose. ..
  36. Artz A, Logan B, Zhu X, Akpek G, Bufarull R, Gupta V, et al. The prognostic value of serum C-reactive protein, ferritin, and albumin prior to allogeneic transplantation for acute myeloid leukemia and myelodysplastic syndromes. Haematologica. 2016;101:1426-1433 pubmed
    We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation...
  37. Kim H, Quan Y, Oh Y, Park J, Park J, Choi Y, et al. Macrophage-Targeted Indocyanine Green-Neomannosyl Human Serum Albumin for Intraoperative Sentinel Lymph Node Mapping in Porcine Esophagus. Ann Thorac Surg. 2016;102:1149-55 pubmed publisher
    ..This study evaluated a new macrophage-targeting fluorescent agent, indocyanine green-neomannosyl human serum albumin (ICG:MSA), for SLN mapping using a custom-made intraoperative color and fluorescence-merged imaging system (..
  38. Huang Y, Wang Y, Pan Q, Wang Y, Ding X, Xu K, et al. Magnetic graphene oxide modified with choline chloride-based deep eutectic solvent for the solid-phase extraction of protein. Anal Chim Acta. 2015;877:90-9 pubmed publisher
    ..Comparison of Fe3O4@GO and Fe3O4@GO-DES was carried out by extracting bovine serum albumin, ovalbumin, bovine hemoglobin and lysozyme...
  39. Lee S, Lee C, Kim B, Thao L, Lee E, Kim J, et al. A novel prototype of albumin nanoparticles fabricated by supramolecular cyclodextrin-adamantane association. Colloids Surf B Biointerfaces. 2016;147:281-290 pubmed publisher
    ..NPs) consisted of ?-cyclodextrin-modified glycol chitosan (GC-CD) and adamantane-conjugated human serum albumin (HSA-ADA) (GC-CD/HSA-ADA NPs) that were facilely prepared by a consequent dropwise mixing and sonication ..
  40. Saito H, Kono Y, Murakami Y, Shishido Y, Kuroda H, Matsunaga T, et al. Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin and Neutrophil-Lymphocyte Ratio in Gastric Cancer Patients. World J Surg. 2018;42:1819-1825 pubmed publisher
    The ratio of C-reactive protein to albumin (CRP/Alb) is a biochemical marker of systemic inflammatory response and has been associated with poor survival in cancer...
  41. Wei J, Zeng Z, Lin Y. Localized Surface Plasmon Resonance (LSPR)-Coupled Fiber-Optic Nanoprobe for the Detection of Protein Biomarkers. Methods Mol Biol. 2017;1571:1-14 pubmed publisher
    ..The control experimentation using 5 mg/mL bovine serum albumin in PBS and nonspecific surface test shows the excellent specificity and selectivity in the detection of f-PSA ..
  42. Wang Y, Zhu M, Liu F, Wu X, Pan D, Liu J, et al. Comparative Studies of Interactions between Fluorodihydroquinazolin Derivatives and Human Serum Albumin with Fluorescence Spectroscopy. Molecules. 2016;21: pubmed
    ..synthesized to study the interaction between fluorine substituted dihydroquinazoline derivatives with human serum albumin (HSA) using fluorescence, circular dichroism and Fourier transform infrared spectroscopy...
  43. Takeuchi W, Suzuki A, Shiga T, Kubo N, Morimoto Y, Ueno Y, et al. Simultaneous Tc-99m and I-123 dual-radionuclide imaging with a solid-state detector-based brain-SPECT system and energy-based scatter correction. EJNMMI Phys. 2016;3:10 pubmed publisher
    ..In the volunteer study, five healthy volunteers were injected with Tc-99m human serum albumin diethylene triamine pentaacetic acid (HSA-D) and scanned (single acquisition)...
  44. Hoang K, Pophristic M, Horan A, Johnston M, McEwen C. High Sensitivity Analysis of Nanoliter Volumes of Volatile and Nonvolatile Compounds using Matrix Assisted Ionization (MAI) Mass Spectrometry. J Am Soc Mass Spectrom. 2016;27:1590-6 pubmed publisher
    ..Analysis of peptides, including a bovine serum albumin digest, and drugs, including drugs in urine without a purification step, are reported using a 1 ?L zero dead ..
  45. Zaky S, Makhlouf N, Abdel Malek M, Bakheet A, Seif H, Hamza H, et al. Multidisciplinary decision making in the management of hepatocellular carcinoma: A hospital-based study. Turk J Gastroenterol. 2015;26:498-505 pubmed publisher
    ..05 for each). There was a significant decrease in the mean serum albumin level after TACE (p=0.000)...
  46. Shukla A, Kapileswar S, Gogtay N, Joshi A, Dhore P, Shah C, et al. Simple biochemical parameters and a novel score correlate with absence of fibrosis in patients with nonalcoholic fatty liver disease. Indian J Gastroenterol. 2015;34:281-5 pubmed publisher
    ..4 [SD 11.5] years) with biopsy-proven NAFLD underwent estimation of platelet count, total bilirubin, AST, ALT, serum albumin, γ-glutamyl transpeptidase (GGT), prothrombin time, serum cholesterol, triglycerides, α2-macroglobulin (..
  47. Jian Hui C, Iskandar E, Cai S, Chen C, Wu H, Xu J, et al. Significance of Onodera's prognostic nutritional index in patients with colorectal cancer: a large cohort study in a single Chinese institution. Tumour Biol. 2016;37:3277-83 pubmed publisher
    ..The PNI level was determined according the following formula: 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm(3))...
  48. Shah M, Sharma A, Wermers R, Kennel K, Kellogg T, Mundi M. Hypocalcemia After Bariatric Surgery: Prevalence and Associated Risk Factors. Obes Surg. 2017;27:2905-2911 pubmed publisher
    ..Nine hundred ninety-nine patients fulfilled the criteria above. After correction for serum albumin concentration, 36 patients had serum calcium ≤8.9 mg/dl. Mean serum calcium was 8.1 ± 0...
  49. Tang N, Skibsted L. Zinc bioavailability from whey. Enthalpy-entropy compensation in protein binding. Food Res Int. 2016;89:749-755 pubmed publisher
    ..Zinc binding to lactoferrin and to bovine serum albumin was found exothermic with ?H=-100kJ/mol and -30kJ/mol, respectively, in aqueous 0.16M NaCl of pH7...
  50. Morotti A, Marini S, Lena U, Crawford K, Schwab K, Kourkoulis C, et al. Significance of admission hypoalbuminemia in acute intracerebral hemorrhage. J Neurol. 2017;264:905-911 pubmed publisher
    Low levels of serum albumin may increase the risk of infections and mortality in critically ill patients...
  51. Sancataldo G, Vetri V, Foderà V, Di Cara G, Militello V, Leone M. Oxidation enhances human serum albumin thermal stability and changes the routes of amyloid fibril formation. PLoS ONE. 2014;9:e84552 pubmed publisher
    ..In this work, we investigated the effect of hydrogen peroxide oxidation on Human Serum Albumin (HSA) structure, thermal stability and aggregation properties...
  52. Song S, Xie T, Ravensbergen K, Hahm J. Ascertaining effects of nanoscale polymeric interfaces on competitive protein adsorption at the individual protein level. Nanoscale. 2016;8:3496-509 pubmed publisher
    ..We examine the competitive adsorption behavior from a binary protein mixture containing bovine serum albumin and fibrinogen at the single protein level...
  53. Guo T, Deng Q, Fang G, Liu C, Huang X, Wang S. Molecularly imprinted upconversion nanoparticles for highly selective and sensitive sensing of Cytochrome c. Biosens Bioelectron. 2015;74:498-503 pubmed publisher
    ..19, and the UCNPs@MIP showed selective recognition for Cyt c among other proteins such as bovine serum albumin (BSA) and Lysozyme (Lyz)...
  54. Zu L, Liu L, Qin Y, Liu H, Yang H. Multifunctional BSA-Au nanostars for photoacoustic imaging and X-ray computed tomography. Nanomedicine. 2016;12:1805-1813 pubmed publisher
    We report the synthesis and characterization of bovine serum albumin-capped Au nanostars (BSA-AuNSs) for dual-modal computed tomography (CT)/photoacoustic (PA) imaging application...
  55. Prinsen B, Rabelink T, Beutler J, Kaysen G, De Boer J, Boer W, et al. Increased albumin and fibrinogen synthesis rate in patients with chronic renal failure. Kidney Int. 2003;64:1495-504 pubmed
    ..In the present study, both albumin and fibrinogen kinetics were measured in vivo in predialysis patients (N = 6), patients on peritoneal dialysis (N ..
  56. Wan A, Xu D, Liu K, Peng L, Cai Y, Chen Y, et al. Efficient expression of stable recombinant human insulin-like growth factor-1 fusion with human serum albumin in Chinese hamster ovary cells. Prep Biochem Biotechnol. 2017;47:678-686 pubmed publisher
    ..5?min according to previous studies. Therefore, IGF-1 was fused to long-circulating serum protein human serum albumin (HSA) and expressed in CHO cells...
  57. Mojahedi M, Bonakdaran S, Hami M, Sheikhian M, Shakeri M, Aiatollahi H. Elevated serum C-reactive protein level and microalbuminuria in patients with type 2 diabetes mellitus. Iran J Kidney Dis. 2009;3:12-6 pubmed
    ..They were divided into a microalbuminuric group (n = 45) and those with a 24-hour urine albumin less than 30 mg/d (n = 42)...
  58. Fei R, Zhang T, Huang Y, Hu Y. Highly selective enrichment of phosphorylated proteins by using Spore@Fe3+ microspheres. Anal Chim Acta. 2017;986:161-170 pubmed publisher
    ..A mixture of bovine serum albumin and ?-casein at 100:1 ratio displayed an enrichment factor higher than 173-fold, which can nearly be ..
  59. Ishii T, Ichikawa T, Minoda K, Kusaka K, Ito S, Suzuki Y, et al. Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization. Biosci Biotechnol Biochem. 2011;75:100-6 pubmed
    Human serum albumin (HSA) contributes to the stabilization of (-)-epigallocatechin gallate (EGCg) in serum. We characterize in the present study the mechanisms for preventing EGCg oxidation by HSA...
  60. Cuya Guizado T, Louro S, Anteneodo C. Dynamics of heme complexed with human serum albumin: a theoretical approach. Eur Biophys J. 2012;41:1033-42 pubmed publisher
    Human serum albumin (HSA) is the most abundant protein in the blood serum. It binds several ligands and has an especially strong affinity for heme, hence becoming a natural candidate for oxygen transport...
  61. Kotani K, Kawabe J, Higashiyama S, Shiomi S. Regional Liver Disorder with Differences in the Accumulation of 99mTc-phytate and 99mTc-galactosyl Human Serum Albumin. World J Nucl Med. 2017;16:320-323 pubmed publisher
    ..which an accumulation of 99mTc-phytate increased, whereas that of 99mTc-galactosyl human serum albumin (GSA) decreased...
  62. Kullak Ublick G, Ismair M, Stieger B, Landmann L, Huber R, Pizzagalli F, et al. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001;120:525-33 pubmed
    ..OATP-B, OATP-C, and OATP8 account for the major part of sodium-independent bile salt, organic anion, and drug clearance of human liver. ..
  63. Shala Lawrence A, Beheshti S, Newman E, Tang M, Krylova S, Leach M, et al. High-precision quantitation of a tuberculosis vaccine antigen with capillary-gel electrophoresis using an injection standard. Talanta. 2017;175:273-279 pubmed publisher
    ..To further improve the performance of our quantitation method, we introduced Bovine Serum Albumin (BSA) as an injection standard to correct for signal variance associated with the injected sample volume...
  64. Leins P, Fligge K, Erbar C. Silique valves as sails in anemochory of Lunaria (Brassicaceae). Plant Biol (Stuttg). 2018;20:238-243 pubmed publisher
    ..The valves in Ricotia can easily be detached (studied in herbarium material and a living plant), but, in contrast to Lunaria, the ripe seeds remain at the replum and its diaphragm, respectively. ..
  65. Chen B, Zhang N, Li C, Li R, Fan A. Synthesis and chromatographic characteristics of iminodisuccinic acid-functionalized silica stationary phase. J Chromatogr A. 2017;1530:120-128 pubmed publisher
    ..5g: 2.0mL: 4.6g. Based on different chromatographic modes, protein mixtures of bovine serum albumin, ribonuclease and lysozyme were successfully separated with IDS-Silica column and IDS-Cu(II)-Silica column, ..
  66. Sakamoto S, Komatsu T, Ueno T, Hanaoka K, Urano Y. Fluorescence detection of serum albumin with a turnover-based sensor utilizing Kemp elimination reaction. Bioorg Med Chem Lett. 2017;27:3464-3467 pubmed publisher
    ..on a protein surface microenvironment, and in particular is highly accelerated in a unique binding pocket of serum albumin. We have designed and synthesized a fluorescently activatable coumarin derivative with a benzisoxazole ..
  67. Zhou Y, Yuan J, Qi C, Shao X, Mou S, Ni Z. Calcium dobesilate may alleviate diabetes?induced endothelial dysfunction and inflammation. Mol Med Rep. 2017;16:8635-8642 pubmed publisher
    ..HUVEC angiogenesis was investigated via migration assays and fluorescein isothiocyanate (FITC)?labelled bovine serum albumin (BSA) permeability assays...
  68. Ascenzi P, di Masi A, Coletta M, Ciaccio C, Fanali G, Nicoletti F, et al. Ibuprofen impairs allosterically peroxynitrite isomerization by ferric human serum heme-albumin. J Biol Chem. 2009;284:31006-17 pubmed publisher
    Human serum albumin (HSA) participates in heme scavenging; in turn, heme endows HSA with myoglobin-like reactivity and spectroscopic properties...
  69. Yokota K, Fukuda M, Katafuchi R, Okamoto T. Nephrotic syndrome and acute kidney injury induced by malathion toxicity. BMJ Case Rep. 2017;2017: pubmed publisher
    ..b>Serum albumin was 2.4?g/dL, urinary protein 8.6?g/gCr and serum creatinine 2.5?mg/dL...
  70. Sun Y, Wang W. Study on the interaction of bioactive compound S-allyl cysteine from garlic with serum albumin. J Food Drug Anal. 2017;25:385-390 pubmed publisher
    ..techniques were used to investigate the interaction of S-allyl cysteine (SAC) from garlic with human serum albumin (HSA). UV-Vis absorption measurements prove the formation of the HSA-SAC complex...
  71. Fischöder T, Laaf D, Dey C, Elling L. Enzymatic Synthesis of N-Acetyllactosamine (LacNAc) Type 1 Oligomers and Characterization as Multivalent Galectin Ligands. Molecules. 2017;22: pubmed publisher
    ..type 1 repeats or LacNAc type 1 at the reducing or non-reducing end, respectively, were conjugated to bovine serum albumin as a protein scaffold by squarate linker chemistry...
  72. Baharvand H, Hashemi S, Kazemi Ashtiani S, Farrokhi A. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Biol. 2006;50:645-52 pubmed
    ..Immunofluorescence analysis revealed the expression of albumin (ALB) and cytokeratin-18 (CK-18)...
  73. Rossi A, Bortolotti N, Vescovo S, Romanello I, Forzano L, Londero A, et al. Ischemia-modified albumin in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013;170:348-51 pubmed publisher
    ..In this context, maternal serum levels of ischemia-modified albumin (IMA) are elevated, reflecting the oxidative stress associated with placental development...