alanine glyoxylate aminotransferase

Summary

Gene Symbol: alanine glyoxylate aminotransferase
Description: alanine-glyoxylate aminotransferase
Alias: AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6, L-alanine: glyoxylate aminotransferase 1, alanine--glyoxylate aminotransferase, hepatic peroxisomal alanine:glyoxylate aminotransferase, serine--pyruvate aminotransferase, serine-pyruvate aminotransferase, serine:pyruvate aminotransferase
Species: human

Top Publications

  1. pmc Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I
    Barbara Cellini
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Proc Natl Acad Sci U S A 107:2896-901. 2010
  2. doi Primary hyperoxaluria type 1: update and additional mutation analysis of the AGXT gene
    Emma L Williams
    Clinical Biochemistry, University College London UCL Hospitals National Health Service NHS Trust, London, UK
    Hum Mutat 30:910-7. 2009
  3. pmc Molecular Insight into the Synergism between the Minor Allele of Human Liver Peroxisomal Alanine:Glyoxylate Aminotransferase and the F152I Mutation
    Barbara Cellini
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    J Biol Chem 284:8349-58. 2009
  4. ncbi Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor
    Marion B Coulter-Mackie
    Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada V6H 3N1
    Protein Expr Purif 41:18-26. 2005
  5. ncbi Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations
    M B Coulter-Mackie
    Department of Pediatrics, University of British Columbia, Children s and Women s Health Centre, Vancouver, BC, Canada
    Mol Genet Metab 89:349-59. 2006
  6. doi Partial trypsin digestion as an indicator of mis-folding of mutant alanine:glyoxylate aminotransferase and chaperone effects of specific ligands. Study of a spectrum of missense mutants
    M B Coulter-Mackie
    Department of Pediatrics, Children and Women s Health Centre of BC, University of British Columbia, 4500 Oak Street, Vancouver, BC, Canada
    Mol Genet Metab 94:368-74. 2008
  7. ncbi Implications of genotype and enzyme phenotype in pyridoxine response of patients with type I primary hyperoxaluria
    Carla G Monico
    Mayo Clinic Hyperoxaluria Center, Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Am J Nephrol 25:183-8. 2005
  8. ncbi Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations
    M J Lumb
    Medical Research Council Laboratory for Molecular Cell Biology and the Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 275:36415-22. 2000
  9. ncbi Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I
    C J Danpure
    FEBS Lett 201:20-4. 1986
  10. ncbi Clinical implications of mutation analysis in primary hyperoxaluria type 1
    Christiaan S van Woerden
    Emma Children s Hospital AMC, Amsterdam, The Netherlands
    Kidney Int 66:746-52. 2004

Detail Information

Publications176 found, 100 shown here

  1. pmc Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I
    Barbara Cellini
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Proc Natl Acad Sci U S A 107:2896-901. 2010
    G41 is an interfacial residue located within the alpha-helix 34-42 of alanine:glyoxylate aminotransferase (AGT)...
  2. doi Primary hyperoxaluria type 1: update and additional mutation analysis of the AGXT gene
    Emma L Williams
    Clinical Biochemistry, University College London UCL Hospitals National Health Service NHS Trust, London, UK
    Hum Mutat 30:910-7. 2009
    Primary hyperoxaluria type 1 (PH1) is an autosomal recessive, inherited disorder of glyoxylate metabolism arising from a deficiency of the alanine:glyoxylate aminotransferase (AGT) enzyme, encoded by the AGXT gene...
  3. pmc Molecular Insight into the Synergism between the Minor Allele of Human Liver Peroxisomal Alanine:Glyoxylate Aminotransferase and the F152I Mutation
    Barbara Cellini
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    J Biol Chem 284:8349-58. 2009
    ..AGT deficiency causes primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder, due to a marked increase in hepatic oxalate production...
  4. ncbi Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor
    Marion B Coulter-Mackie
    Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada V6H 3N1
    Protein Expr Purif 41:18-26. 2005
    ..AGT) is a human liver peroxisomal enzyme whose deficiency results in, primary hyperoxaluria type 1 (PH1), a fatal metabolic disease. AGT requires a pyridoxal phosphate (PLP) co-factor in its active site...
  5. ncbi Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations
    M B Coulter-Mackie
    Department of Pediatrics, University of British Columbia, Children s and Women s Health Centre, Vancouver, BC, Canada
    Mol Genet Metab 89:349-59. 2006
    ..aminotransferase (AGT) is a liver peroxisomal enzyme, deficiency of which results in primary hyperoxaluria type 1 (PH1). More than 65 PH1-related mutations are now documented in the AGT gene (AGXT), of which about 50% are missense...
  6. doi Partial trypsin digestion as an indicator of mis-folding of mutant alanine:glyoxylate aminotransferase and chaperone effects of specific ligands. Study of a spectrum of missense mutants
    M B Coulter-Mackie
    Department of Pediatrics, Children and Women s Health Centre of BC, University of British Columbia, 4500 Oak Street, Vancouver, BC, Canada
    Mol Genet Metab 94:368-74. 2008
    ..aminotransferase (AGT) is a liver peroxisomal enzyme whose deficiency results in primary hyperoxaluria type 1 (PH1). More than 75 PH1 mutations are now documented in the AGT gene (AGXT), of which about 50% are missense...
  7. ncbi Implications of genotype and enzyme phenotype in pyridoxine response of patients with type I primary hyperoxaluria
    Carla G Monico
    Mayo Clinic Hyperoxaluria Center, Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Am J Nephrol 25:183-8. 2005
    Marked hyperoxaluria due to liver-specific deficiency of alanine:glyoxylate aminotransferase activity (AGT) characterizes type I primary hyperoxaluria (PHI)...
  8. ncbi Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations
    M J Lumb
    Medical Research Council Laboratory for Molecular Cell Biology and the Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 275:36415-22. 2000
    The autosomal recessive disorder primary hyperoxaluria type 1 (PH1) is caused by a deficiency of the liver-specific pyridoxal-phosphate-dependent enzyme alanine:glyoxylate aminotransferase (AGT)...
  9. ncbi Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I
    C J Danpure
    FEBS Lett 201:20-4. 1986
    ..This enzyme deficiency explains most of the biochemical characteristics of the disease and means that primary hyperoxaluria type I should be added to the rather select list of peroxisomal disorders...
  10. ncbi Clinical implications of mutation analysis in primary hyperoxaluria type 1
    Christiaan S van Woerden
    Emma Children s Hospital AMC, Amsterdam, The Netherlands
    Kidney Int 66:746-52. 2004
    Primary hyperoxaluria type 1 (PH1) is an inborn error of glyoxylate metabolism with an extensive clinical and genetic heterogeneity...
  11. ncbi Selected exonic sequencing of the AGXT gene provides a genetic diagnosis in 50% of patients with primary hyperoxaluria type 1
    Emma Williams
    Clinical Biochemistry, University College London Hospitals, London, United Kingdom
    Clin Chem 53:1216-21. 2007
    Definitive diagnosis of primary hyperoxaluria type 1 (PH1) requires analysis of alanine:glyoxylate aminotransferase (AGT) activity in the liver...
  12. ncbi Construction, purification and characterization of untagged human liver alanine-glyoxylate aminotransferase expressed in Escherichia coli
    Barbara Cellini
    Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Protein Pept Lett 15:153-9. 2008
    ..Alanine:glyoxylate aminotransferase (AGT) is a peroxisomal pyridoxal 5'-phosphate (PLP) dependent enzyme which catalyzes the transamination of alanine and ..
  13. ncbi Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1
    Xiaoxuan Zhang
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 331:643-52. 2003
    ..AGT) is responsible for the potentially lethal hereditary kidney stone disease primary hyperoxaluria type 1 (PH1)...
  14. ncbi A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Genomics 13:215-8. 1992
    ..AGT; HGMW-approved symbol for the gene--AGXT) cDNA from the liver of a primary hyperoxaluria type 1 (PH1) patient who had normal levels of hepatic peroxisomal immunoreactive AGT protein, but no AGT catalytic activity...
  15. pmc In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase
    Erin D Hopper
    Department of Biology and Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Biol Chem 283:30493-502. 2008
    ..type I is a severe kidney stone disease caused by mutations in the protein alanine:glyoxylate aminotransferase (AGT)...
  16. pmc Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    J Cell Biol 111:2341-51. 1990
    We have previously shown that in some patients with primary hyperoxaluria type 1 (PH1), disease is associated with mistargeting of the normally peroxisomal enzyme alanine/glyoxylate aminotransferase (AGT) to mitochondria (Danpure, C.J...
  17. ncbi Molecular etiology of primary hyperoxaluria type 1: new directions for treatment
    Christopher J Danpure
    Department of Biology, University College London, London, UK
    Am J Nephrol 25:303-10. 2005
    Primary hyperoxaluria type 1 (PH1) is a rare autosomal-recessive disorder caused by a deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase (AGT)...
  18. pmc Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications
    Barbara Cellini
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Biochem J 408:39-50. 2007
    Human hepatic peroxisomal AGT (alanine:glyoxylate aminotransferase) is a PLP (pyridoxal 5'-phosphate)-dependent enzyme whose deficiency causes primary hyperoxaluria Type I, a rare autosomal recessive disorder...
  19. pmc The peroxisomal targeting sequence type 1 receptor, Pex5p, and the peroxisomal import efficiency of alanine:glyoxylate aminotransferase
    T G Knott
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 352:409-18. 2000
    ..in which the cytosolic levels of two peroxisomal proteins, catalase and alanine:glyoxylate aminotransferase (AGT), are much higher than those found in human (Homo sapiens) hepatocytes, for example...
  20. ncbi Identification of 5 novel mutations in the AGXT gene
    O Basmaison
    Laboratoire de Biochimie Pédiatrique, Hopital Debrousse, Lyon, France
    Hum Mutat 15:577. 2000
    ..Their consequence is always a lack of enzymatic activity of the Alanine-Glyoxylate Aminotransferase (AGT); for 4 of them, we were able to deduce that they were associated to the absence of AGT protein...
  21. ncbi A serine-to-phenylalanine substitution leads to loss of alanine:glyoxylate aminotransferase catalytic activity and immunoreactivity in a patient with primary hyperoxaluria type 1
    Y Minatogawa
    Department of Biochemistry, Wakayama Medical College, Japan
    Hum Mol Genet 1:643-4. 1992
  22. doi Human liver peroxisomal alanine:glyoxylate aminotransferase: Different stability under chemical stress of the major allele, the minor allele, and its pathogenic G170R variant
    Barbara Cellini
    Dipartimento di Scienze della Vita e della Riproduzione, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8 37134 Verona, Italy
    Biochimie 92:1801-11. 2010
    ..1 M urea. These biochemical results are discussed in the light of the characteristics of the enzymatic phenotype of PH1 patients bearing G170R mutation in AGT-Mi and the positive response of these patients to pyridoxine treatment.
  23. pmc Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer
    Eduardo C Salido
    Unidad Investigación, Hospital Universitario Canarias, University La Laguna, Tenerife 38320, Spain
    Proc Natl Acad Sci U S A 103:18249-54. 2006
    ..Hepatic expression of human AGT1, the protein encoded by AGXT, by adenoviral vector-mediated gene transfer in Agxt(-/-) mice normalized urinary ..
  24. ncbi Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus
    Pia A J Huber
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 280:27111-20. 2005
    Although human alanine:glyoxylate aminotransferase (AGT) is imported into peroxisomes by a Pex5p-dependent pathway, the properties of its C-terminal tripeptide (KKL) are unlike those of any other type 1 peroxisomal targeting sequence (..
  25. pmc Primary hyperoxaluria type 1 in the Canary Islands: a conformational disease due to I244T mutation in the P11L-containing alanine:glyoxylate aminotransferase
    A Santana
    Department of Pediatrics, University of California School of Medicine, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 100:7277-82. 2003
    Primary hyperoxaluria type 1 (PH1) is an inborn error of metabolism resulting from a deficiency of alanine:glyoxylate aminotransferase (AGXT; EC 2.6.1.44)...
  26. ncbi Evaluation of mutation screening as a first line test for the diagnosis of the primary hyperoxalurias
    Gill Rumsby
    Clinical Biochemistry, UCL Hospitals, London, United Kingdom
    Kidney Int 66:959-63. 2004
    A definitive diagnosis of primary hyperoxaluria type 1 (PH1) and primary hyperoxaluria type 2 (PH2) requires the measurement of alanine:glyoxylate aminotransferase (AGT) and glyoxylate reductase (GR) activities, respectively, in a liver ..
  27. ncbi Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Genomics 10:34-42. 1991
    ..6.1.44), the deficient enzyme in primary hyperoxaluria type 1 (PH1) (P. E. Purdue, Y. Takada, and C. J. Danpure, J. Cell Biol. 111: 2341-2351, 1990)...
  28. ncbi AGXT gene mutations and their influence on clinical heterogeneity of type 1 primary hyperoxaluria
    A Amoroso
    Section of Genetics, Department of Reproductive and Developmental Science, University of Trieste, Via dell Istria 65 1 34137 Trieste, Italy
    J Am Soc Nephrol 12:2072-9. 2001
    Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder that is caused by a deficiency of alanine: glyoxylate aminotransferase (AGT), which is encoded by a single copy gene (AGXT)...
  29. pmc Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Proc Natl Acad Sci U S A 88:10900-4. 1991
    ..disease is associated with a unique protein sorting defect in which hepatic L-alanine:glyoxylate aminotransferase (AGT; EC 2.6.1.44), which is normally peroxisomal, is mistargeted to mitochondria...
  30. pmc Primary hyperoxaluria type 1: a cluster of new mutations in exon 7 of the AGXT gene
    C von Schnakenburg
    Department of Molecular Pathology, University College London Hospitals, UK
    J Med Genet 34:489-92. 1997
    Primary hyperoxaluria type 1 (PH1) is a severe autosomal recessive inborn error of glyoxylate metabolism caused by deficiency of the hepatic peroxisomal enzyme alanine:glyoxylate aminotransferase...
  31. pmc Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation
    C J Danpure
    Biochemical Genetics Research Group, Medical Research Council Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Am J Hum Genet 53:417-32. 1993
    Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disease caused by a deficiency of the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT)...
  32. ncbi Contribution of angiotensin I converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertension
    U F Mondorf
    Division of Nephrology, Medizinische Klinik IV, , Frankfurt, Germany
    Am J Hypertens 11:174-83. 1998
    ..of the insertion/deletion polymorphisms of the ACE gene and the M235T polymorphism of the Angiotensinogen (Agt) gene in patients with essential hypertension in comparison with normotensive subjects...
  33. pmc Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40
    S J Cook
    School of Biological Sciences, University of Manchester
    Br J Pharmacol 114:143-51. 1995
    ..The tracheal relaxant action of SCA40 was unaffected by suramin (100 microM) or 8-(p)-sulphophenyltheophylline (8-SPT; 140 microM). 2...
  34. ncbi Oxalate synthesis in mammals: properties and subcellular distribution of serine:pyruvate/alanine:glyoxylate aminotransferase in the liver
    A Ichiyama
    First Department of Biochemistry, Hamamatsu University School of Medicine, Shizuoka, Japan
    Mol Urol 4:333-40. 2000
    Primary hyperoxaluria Type 1 (PH1) is caused by a functional deficiency of a liver enzyme, serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT), which catalyzes transamination between L-serine or l-alanine as an amino acid ..
  35. ncbi Combined liver-kidney transplantation in primary hyperoxaluria type 1
    P Cochat
    Unité de Néphrologie Pédiatrique, Hopital Edouard Herriot, 69437 Lyon Cedex 03, France
    Eur J Pediatr 158:S75-80. 1999
    Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder characterised by an increased urinary excretion of calcium oxalate, leading to recurrent urolithiasis, nephrocalcinosis and accumulation of insoluble oxalate ..
  36. pmc Contractions mediated by alpha 1-adrenoceptors and P2-purinoceptors in a cat colon circular muscle
    K Venkova
    Department of Physiology, Michigan State Univ, East Lansing 48823 1101
    Br J Pharmacol 112:1237-43. 1994
    ..blue 2 (100 microM), a selective antagonist of the P2Y-purinoceptor, and 8-(p-sulphophenyl)-theophylline (8-SPT) (1 microM), a selective antagonist of the PI-purinoceptor, did not antagonize the contractile responses to alpha,..
  37. pmc A role for mast cells in adenosine A3 receptor-mediated hypotension in the rat
    J P Hannon
    Preclinical Research, Sandoz Pharma Ltd, Basel, Switzerland
    Br J Pharmacol 115:945-52. 1995
    ..which the A3 receptor-mediated response had been isolated by pretreatment with 8-(p-sulphophenyl) theophylline (8-SPT)), induced dose-related falls in blood pressure accompanied at higher doses by small falls in heart rate...
  38. pmc Mammalian alanine/glyoxylate aminotransferase 1 is imported into peroxisomes via the PTS1 translocation pathway. Increased degeneracy and context specificity of the mammalian PTS1 motif and implications for the peroxisome-to-mitochondrion mistargeting of
    A Motley
    Department of Biochemistry, E C Slater Institute, University of Amsterdam, The Netherlands
    J Cell Biol 131:95-109. 1995
    ..peroxisomal in most normal humans, but in some patients with the hereditary disease primary hyperoxaluria type 1 (PH1), AGT is mislocalized to the mitochondria...
  39. doi Correction of hyperoxaluria by liver repopulation with hepatocytes in a mouse model of primary hyperoxaluria type-1
    Jinlan Jiang
    Department of Medicine, and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Transplantation 85:1253-60. 2008
    Primary hyperoxaluria type-1 (PH1) is an autosomal recessive disease characterized by excessive oxalate production by hepatocytes caused by the deficiency of peroxisomal alanine-glyoxylate aminotransferase (AGT) activity...
  40. ncbi Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study
    S Takami
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Am J Hypertens 13:121-7. 2000
    ..four candidate gene polymorphisms: angiotensin converting enzyme (ACE)/Insertion(I)-Deletion(D), angiotensinogen (AGT)/M235T, angiotensin II type 1 receptor (AT1)/ A1166C, type 2 receptor (AT2)/C3123A, to examine the association ..
  41. ncbi Differential rates of reversibility of ecteinascidin 743-DNA covalent adducts from different sequences lead to migration to favored bonding sites
    M Zewail-Foote
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA
    J Am Chem Soc 123:6485-95. 2001
    ..Quite unexpectedly, it was found that although the rates of alkylation are similar for the 5'-AGT and 5'-AGC sequences, reversal from the 5'-AGT sequence occurs faster than from the 5'-AGC sequence...
  42. pmc Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis
    Carla G Monico
    Mayo Clinic Hyperoxaluria Center, Division of Nephrology and Hypertension, Departments of Internal Medicine and Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 52:1096-103. 2008
    ..arises from mutations in 2 separate loci, AGXT and GRHPR, the causes of primary hyperoxaluria (PH) types 1 (PH1) and 2 (PH2), respectively...
  43. ncbi Ketotifen in prevention and therapy of food allergy
    P Molkhou
    Allergy Department, , Paris, France
    Ann Allergy 59:187-93. 1987
    ..Food allergy was proved by clinical history, exclusion diet positive challenge test, skin prick tests (SPT) total IgE (PRIST) and specific IgE (RAST)...
  44. ncbi Genetic heterogeneity in primary hyperoxaluria type 1: impact on diagnosis
    Marion B Coulter-Mackie
    Department of Pediatrics, University of British Columbia, Children s and Women s Health Centre of B C 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
    Mol Genet Metab 83:38-46. 2004
    Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disease characterized by progressive kidney failure due to renal deposition of calcium oxalate...
  45. doi Transplantation procedures in children with primary hyperoxaluria type 1: outcome and longitudinal growth
    Florian Brinkert
    Department of Pediatrics, Pediatric Gastroenterology and Hepatology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Transplantation 87:1415-21. 2009
    Cure of the metabolic defect in primary hyperoxaluria type 1 (PH1) is possible with liver transplantation (LTx). Preemptive LTx (PLTx) was promoted to prevent chronic kidney disease due to nephrocalcinosis and urolithiasis...
  46. pmc Characterization of the adenosine receptors mediating hypothermia in the conscious mouse
    R Anderson
    Department of Cellular Sciences, Glaxo Research and Development Ltd, Ware, Hertfordshire
    Br J Pharmacol 113:1386-90. 1994
    ..1 mg kg-1, i.p.). 4.8(p-Sulphophenyl)theophylline (8-SPT, 10 and 30 mg kg-1, i.p...
  47. pmc Phenotypic correction of a mouse model for primary hyperoxaluria with adeno-associated virus gene transfer
    Eduardo Salido
    Centre for Biomedical Research on Rare Diseases, Hospital Universitario Canarias, Instituto Tecnologías Biomédicas, University of La Laguna, Tenerife, Spain
    Mol Ther 19:870-5. 2011
    Primary hyperoxaluria type I (PH1) is an inborn error of metabolism caused by deficiency of the hepatic enzyme alanine-glyoxylate aminotransferase (AGXT or AGT) which leads to overproduction of oxalate by the liver and subsequent ..
  48. ncbi Molecular aetiology of primary hyperoxaluria type 1
    Christopher J Danpure
    Department of Biology, University College London, London, UK
    Nephron Exp Nephrol 98:e39-44. 2004
    Primary hyperoxaluria type 1 (PH1) is a rare autosomal-recessive disorder, caused by a deficiency of the liver-specific intermediary-metabolic enzyme alanine:glyoxylate aminotransferase (AGT)...
  49. ncbi Preliminary evidence for ethnic differences in primary hyperoxaluria type 1 genotype
    Marion B Coulter-Mackie
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    Am J Nephrol 25:264-8. 2005
    Primary hyperoxaluria type 1 (PH1) is caused by a deficiency of peroxisomal alanine:glyoxylate aminotransferase (AGT). In about one third of patients, enzymatically active AGT is synthesized but is mistargeted to mitochondria...
  50. ncbi Primary hyperoxaluria type 1: AGT mistargeting highlights the fundamental differences between the peroxisomal and mitochondrial protein import pathways
    Christopher J Danpure
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochim Biophys Acta 1763:1776-84. 2006
    Primary hyperoxaluria type 1 (PH1) is an atypical peroxisomal disorder, as befits a deficiency of alanine:glyoxylate aminotransferase (AGT), which is itself an atypical peroxisomal enzyme...
  51. pmc Further investigations into adenosine A1 receptor-mediated contraction in rat colonic muscularis mucosae and its augmentation by certain alkylxanthine antagonists
    J J Reeves
    Department of Cellular Science, Glaxo Research, Ware, Herts
    Br J Pharmacol 114:999-1004. 1995
    1. The alkylxanthine antagonists, 8-phenyltheophylline (8-PT), 8-p-sulphophenyltheophylline (8-SPT) and 1,3,7-trimethylxanthine (caffeine) produced rightward displacements of contractile concentration-effect curves to 5'-N-..
  52. pmc Cellular transfection to deliver alanine-glyoxylate aminotransferase to hepatocytes: a rational gene therapy for primary hyperoxaluria-1 (PH-1)
    Sweaty Koul
    Signal Transduction Laboratory, Program in Urosciences, Division of Urology, Department of Surgery, University of Colorado School of Medicine, Denver, Colo 80262, USA
    Am J Nephrol 25:176-82. 2005
    ..metabolism caused by deficiency in the liver-specific peroxisomal enzyme alanine-glyoxalate transaminase 1 (AGT) resulting in the increased oxidation of glyoxalate to oxalate...
  53. ncbi Molecular aetiology of primary hyperoxaluria and its implications for clinical management
    Christopher J Danpure
    Department of Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Expert Rev Mol Med 6:1-16. 2004
    The primary hyperoxalurias type 1 (PH1) and type 2 (PH2) are autosomal recessive calcium oxalate kidney stone diseases caused by deficiencies of the metabolic enzymes alanine:glyoxylate aminotransferase (AGT) and glyoxylate/..
  54. ncbi The mouse alanine:glyoxylate aminotransferase gene (Agxt1): cloning, expression, and mapping to chromosome 1
    X M Li
    Department of Pediatrics, UCSF School of Medicine, San Francisco, California 94143, USA
    Somat Cell Mol Genet 25:67-77. 1999
    ..Thus, we have carried out the molecular cloning and analysis of the mouse Agxt1 gene, as a necessary first step towards the generation of a mouse model for PH1...
  55. ncbi [Transient global amnesia. Case-control study of 24 cases]
    X C Moreno Lugris
    , Servicio de Medicina Interna, Hospital Xeral Calde, Lugo
    Rev Neurol 24:554-7. 1996
    Transient global amnesia (AGT) is a well-defined syndrome of unknown aetiology. It is generally believed to be of vascular origin. Other theories suggest epilepsy or migraine as the cause...
  56. pmc Failure of CGS15943A to block the hypotensive action of agonists acting at the adenosine A3 receptor
    M Patel
    Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 113:741-8. 1994
    ..the hypotension was not blocked by pretreatment with the xanthine antagonist, 8-P-sulphophenyltheophylline (8-sPT; 40 mg kg-1, i.v.), whereas the bradycardia was attenuated...
  57. ncbi Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase
    H H Xue
    First Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    J Biol Chem 274:16028-33. 1999
    ..pathways, one initiated by serine dehydratase, another by serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT), and the other involving serine hydroxymethyltransferase and the mitochondrial glycine cleavage enzyme system (..
  58. pmc Purinoceptors mediating relaxation and spasm in the rat gastric fundus
    M S Matharu
    Department of Physiological Sciences, Medical School, Manchester University
    Br J Pharmacol 106:395-403. 1992
    ..3 and 30 microM), an adenosine-uptake inhibitor. 8-Sulphophenyl-theophylline (8-SPT, 30 microM), a selective P1-purinoceptor antagonist, antagonized adenosine and 5'-N-ethylcarboxamidoadenosine (NECA)..
  59. pmc Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards
    Rachel Loeber
    Department of Medicinal Chemistry and Cancer Center and Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:787-95. 2008
    ..Here, we show that the DNA repair protein, O (6)-alkylguanine DNA alkyltransferase (AGT), can be readily cross-linked to DNA in the presence of nitrogen mustards...
  60. ncbi Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site region
    C Deng
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854 8020, USA
    Pharmacogenetics 9:81-7. 1999
    O6-Alkylguanine-DNA alkyltransferase (AGT, EC 2.1.1.63) is a principle DNA repair protein in repairing O6-alkylguanine in DNA, a major premutagenic lesion produced by environmental and therapeutic alkylating agents...
  61. ncbi The Saccharomyces cerevisiae SPT14 gene is essential for normal expression of the yeast transposon, Ty, as well as for expression of the HIS4 gene and several genes in the mating pathway
    J S Fassler
    Department of Biology, University of Iowa, Iowa City 52242
    Mol Gen Genet 230:310-20. 1991
    To investigate the role of the trans-acting transcription factor encoded by the essential SPT14 (SPT = Suppressor of Ty insertion mutations) gene, we have cloned, mapped and sequenced the gene...
  62. ncbi The natural history of sensitizations to food and aeroallergens in atopic dermatitis: a 4-year follow-Up
    A Patrizi
    Department of Clinical and Experimental Medicine, Division of Dermatology, and Department of Pediatrics, University of the Study of Bologna, Bologna, Italy
    Pediatr Dermatol 17:261-5. 2000
    ..An ARD appeared in 38% of all patients: in 75% of those with severe AD and in 54% of those with a positive first SPT. Allergic screening should be carried out at an early age, especially in severe AD, since SPT positivity to food ..
  63. ncbi O6-alkylguanine-DNA alkyltransferase in cutaneous T-cell lymphoma: implications for treatment with alkylating agents
    M E Dolan
    Department of Medicine, University of Chicago, Illinois 60637, USA
    Clin Cancer Res 5:2059-64. 1999
    ..thought to be due to the presence in tumor cells of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT)...
  64. ncbi [Urticaria in relation to mite sensitivity and immunotherapy with Injection dermatophagoidei farinae]
    Dao rong Xing
    Department of Pathogen Biology, Xuzhou Medical College, Xuzhou 221002, China
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 26:422-7. 2008
    ..To investigate the prevalence of mite sensitivity in patients with urticaria or other skin rashes, and to observe the clinical efficacy of a specific immunotherapy (SIT) by the Injection dermatophagoides farinae for the patients...
  65. pmc Novel functional association of serine palmitoyltransferase subunit 1-A peptide in sphingolipid metabolism with cytochrome P4501A1 transactivation and proliferative capacity of the human Glioma LN18 brain tumor cell line
    T Yerokun
    Department of Biological Sciences, Clark Atlanta University, Atlanta, GA 30314, USA
    Int J Environ Res Public Health 3:252-61. 2006
    ..modulators of cytochrome P4501A1, Cyp1A1, expression also perturb the activity of serine palmitoyltransferase, SPT, a heterodimeric protein responsible for catalyzing the first reaction in sphingolipid biosynthesis...
  66. doi Utility of diagnostic tests in the follow-up of egg-allergic children
    Ma C Diéguez
    Servicio de Alergologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Clin Exp Allergy 39:1575-84. 2009
    Better knowledge of the accuracy of a skin prick test (SPT) and specific IgE (sIgE) levels to egg allergens would help to identify persistent egg-allergic children, avoiding unnecessary risky challenges...
  67. ncbi Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains
    Hirotaka Matsuo
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 277:21017-26. 2002
    We identified a novel Na(+)-independent acidic amino acid transporter designated AGT1 (aspartate/glutamate transporter 1)...
  68. ncbi Sleep EEG of patients with obsessive-compulsive disorder
    F Hohagen
    Psychiatric Department, University of Freiburg, Germany
    Eur Arch Psychiatry Clin Neurosci 243:273-8. 1994
    ..Sleep efficiency was significantly lower and wake % SPT was significantly increased in the patient group compared to healthy subjects...
  69. doi Sensitivity and specificity of different skin prick tests with latex extracts in pediatric patients with suspected natural rubber latex allergy--a cohort study
    Roberto Bernardini
    Paediatric Allergy and Pneumology Centre, Anna Meyer Children s Hospital, Florence, Italy
    Pediatr Allergy Immunol 19:315-8. 2008
    Skin prick tests (SPT) with latex extracts are commonly used in the diagnostic approach of natural rubber latex (NRL) allergy. Non-ammoniated latex extracts are commonly utilized for this purpose...
  70. ncbi Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of "remote preconditioning"
    A Takaoka
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 33:556-64. 1999
    ..This study examined the changes in myocardial energy metabolism during myocardial ischemia after "remote preconditioning" and investigated the involvement of adenosine receptors in the mechanisms of this effect...
  71. ncbi [Usefulness of skin prick test using bifurcated needle for the diagnosis of food allergy in infantile atopic dermatitis--1st report. Case of egg allergy]
    Mika Ogata
    Division of Pediatric Allergy, Sagamihara National Hospital
    Arerugi 57:843-52. 2008
    We investigated the usefulness of skin prick test (SPT) for the diagnosis of egg white (EW) allergy in infants with atopic dermatitis who showed negative to EW CAPRAST, and followed up the EW-CAPRAST in this study.
  72. ncbi Angiotensin-TGF-beta 1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages
    Bruce D Uhal
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Curr Pharm Des 13:1247-56. 2007
    ..isolated from patients with Idiopathic Pulmonary Fibrosis (IPF) synthesize the ANGII precursor angiotensinogen (AGT) constitutively...
  73. ncbi Single-patient drug trial methodology for allergic rhinitis
    Donald P Reitberg
    Scientific Affairs, Opt e scrip, Inc, Morristown, NJ 07960 4455, USA
    Ann Pharmacother 36:1366-74. 2002
    Historically, single-patient trials (SPTs) have been specifically designed for each patient, requiring significant time and effort for execution. There has been no previous attempt to standardize an SPT for routine commercial availability.
  74. pmc Direct effects of adenylyl 5'-(beta,gamma-methylene)diphosphonate, a stable ATP analogue, on relaxant P1-purinoceptors in smooth muscle
    S M Hourani
    Receptors and Cellular Regulation Research Group, School of Biological Sciences, University of Surrey, Guildford
    Br J Pharmacol 104:685-90. 1991
    ..3. The P1 antagonist 8-(p-sulphophenyl)theophylline (8-SPT) (100 microM) did not affect the responses to ATP, 2-MeSATP or AMPCPP in either tissue, but inhibited the responses ..
  75. ncbi [Cerebral blood flow study using SPECT in patients with memory disorders]
    E Valiente
    , Hospital de San Juan, Alicante,
    Rev Neurol 25:460-4. 1997
    ..OBJECTIVE: To study the cerebral blood flow in patients with temporary global amnesia (AGT) or permanent global amnesia (AGP) using functional neuroimaging techniques...
  76. ncbi The impact of smoking status, disease stage, and index tumor site on second primary tumor incidence and tumor recurrence in the head and neck retinoid chemoprevention trial
    F R Khuri
    University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 10:823-9. 2001
    ..In a previous Phase III study, we observed that high doses of 13-cis-retinoic acid reduced the SPT rate in this disease...
  77. ncbi Halogen immunoassay, a new method for the detection of sensitization to fungal allergens; comparisons with conventional techniques
    Brett James Green
    Department of Medicine, The University of Sydney, Sydney, NSW, Australia
    Allergol Int 55:131-9. 2006
    ..We compared the halogen immunoassay (HIA), which uses allergens expressed by freshly germinated spores that are bound to protein binding membranes (PBM), with the commercial Pharmacia UniCap assay (CAP) and with skin prick tests (SPT).
  78. ncbi Plasma angiotensinogen concentrations in obese patients
    S Umemura
    Second Department of Internal Medicine, Yokohama City University, School of Medicine, Kanazawa-ku, Yokohama, Japan
    Am J Hypertens 10:629-33. 1997
    ..relationship between obesity and hypertension has been recognized, and plasma angiotensinogen concentrations (p-AGT) have been reported to correlate with blood pressure (BP)...
  79. doi Osmoregulatory fluid intake but not hypovolemic thirst is intact in mice lacking angiotensin
    Michael J McKinley
    Howard Florey Institute, University of Melbourne, Parkville, Vic, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1533-43. 2008
    ..stimuli were investigated in mice lacking angiotensin II as a result of deletion of the angiotensinogen gene (Agt-/- mice), and in C57BL6 wild-type (WT) mice...
  80. ncbi Atopy patch test in the diagnosis of food allergy in children with atopic eczema dermatitis syndrome
    B Cudowska
    III Department of Paediatrics, Medical University of Białystok, Poland
    Rocz Akad Med Bialymst 50:261-7. 2005
    ..The diagnostic work-up of suspected immediate food reactions includes skin prick tests (SPT) and the measurement of food-specific antibodies (sIgE)...
  81. ncbi N-ras mutations in myeloid leukemias
    G Saglio
    , Italy
    Tumori 75:337-40. 1989
    ..reaction technique in twenty patients with acute myeloblastic leukemia (AML) at onset and in four patients with Ph1 positive chronic myelogeneous leukemia (CML) either in chronic phase or in blast crisis...
  82. doi A novel selective growth medium-PCR assay to isolate and detect Sphingomonas in environmental samples
    Mi Sung Yim
    Department of Biology, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario, Canada P7B 5E1
    J Microbiol Methods 82:19-27. 2010
    ..In addition, two sets of PCR primers targeting the serine palmitoyltransferase gene (spt), a crucial sphingolipid biosynthesis gene, were developed...
  83. ncbi A clinical comparison of three powered toothbrushes
    G A van der Weijden
    Department of Periodontology, ACTA, Academic Center for Dentistry Amsterdam, The Netherlands
    J Clin Periodontol 29:1042-7. 2002
    ..was to compare the ability of the Braun Oral-B 3D Excel power toothbrush (BPT), the Sonicare power toothbrush (SPT) and the Philips Sensiflex 2000 (HX 2550) power toothbrush (PPT) to control plaque and reduce experimentally ..
  84. ncbi Adrenal gland trauma is associated with high injury severity and mortality
    Stanislaw P Stawicki
    Department of Surgery, St Lukes Hospital and Health Network, Bethlehem, Pennsylvania 18015, USA
    Curr Surg 60:431-6. 2003
    To review a statewide experience of adrenal gland trauma (AGT), incidence, demographics, associated injuries, Injury Severity Score (ISS), Glasgow Coma Scale (GCS), mechanisms of injury, and complications, associated with AGT.
  85. ncbi Recurrence in patients with oral and oropharyngeal squamous cell carcinoma: human papillomavirus and other risk factors
    Kerstin Rosenquist
    Department of Oral Surgery and Oral Medicine, Faculty of Odontology, Malmo University, Malmo, Sweden
    Acta Otolaryngol 127:980-7. 2007
    The results confirm that tumour stage influences the risk of recurrence/second primary tumour (SPT)...
  86. ncbi Angiotensinogen gene polymorphism (Met235Thr) influences visceral obesity and insulin resistance in obese Japanese women
    Yasuto Takakura
    Department of Internal Medicine, Fukuchiyama City Hospital, Fukuchiyama 620 8505, Japan
    Metabolism 55:819-24. 2006
    To investigate the relationship between angiotensinogen (AGT) Met235Thr polymorphism (M235T) and human obesity, because AGT is regarded as one of the cytokines produced from adipocytes and serum AGT concentrations are reported to be ..
  87. doi [Relationship between T704C polymorphism of angiotensinogen gene and cerebral hemorrhage in Han people in Changsha]
    Yi Zeng
    Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:314-20. 2010
    To investigate the relationship between T704C polymorphism of angiotensinogen (AGT) gene and cerebral hemorrhage and its impact on the levels of blood pressure in Han people in Changsha.
  88. ncbi Risk factors for aspiration pneumonia after percutaneous endoscopic gastrostomy
    Toshiro Kitamura
    Department of Surgery, Municipal Kouyo Hospital, Hokuto City, Yamanashi, Japan
    Gerontology 53:224-7. 2007
    ..Percutaneous endoscopic gastrostomy (PEG) is generally used for long-term enteral nutrition. Patients who require PEG placement are often very sick, and postoperative complications, especially aspiration pneumonia, can be fatal...
  89. pmc Detailed dissection of the chromosomal region containing the Ph1 locus in wheat Triticum aestivum: with deletion mutants and expression profiling
    Nadia Al-Kaff
    John Innes Centre, Norwich Research Park, Colney Lane, Norwich, Norfolk NR4 7UH, UK
    Ann Bot 101:863-72. 2008
    Understanding Ph1, a dominant homoeologous chromosome pairing suppressor locus on the long arm of chromosome 5B in wheat Triticum aestivum L., is the core of the investigation in this article...
  90. ncbi Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
    T Skorski
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 86:726-36. 1995
    ..tyrosine kinase is responsible for initiating and maintaining the leukemic phenotype of Philadelphia chromosome (Ph1)-positive cells...
  91. ncbi Attenuation of bleomycin-induced pulmonary fibrosis by intratracheal administration of antisense oligonucleotides against angiotensinogen mRNA
    Xiaopeng Li
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Curr Pharm Des 13:1257-68. 2007
    ..epithelial cells in response to BLEO could be abrogated by antisense oligonucleotides against angiotensinogen (AGT) mRNA and requires angiotensin II (ANG II) synthesis de novo [17]...
  92. ncbi Reduction of plasma angiotensin II to normal levels by antisense oligodeoxynucleotides against liver angiotensinogen cannot completely attenuate vascular remodeling in spontaneously hypertensive rats
    M Sugano
    Department of Bioclimatology and Medicine, Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    J Hypertens 18:725-31. 2000
    The exact role of angiotensinogen (AGT) in vascular remodeling has yet to be determined...
  93. ncbi Reactions of serine palmitoyltransferase with serine and molecular mechanisms of the actions of serine derivatives as inhibitors
    Hiroko Ikushiro
    Department of Biochemistry, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Biochemistry 43:1082-92. 2004
    Serine palmitoyltransferase (SPT) is a key enzyme in sphingolipid biosynthesis and catalyzes the decarboxylative condensation of L-serine and palmitoyl coenzyme A to 3-ketodihydrosphingosine...
  94. ncbi Comparison and evaluation of several Dermatophagoides pteronyssinus allergen extracts for skin prick test
    Jin lu Sun
    Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Chin Med Sci J 24:86-90. 2009
    To evaluate the significance of several Dermatophagoides pteronyssinus allergen extracts for skin prick test (SPT) in patients allergic to Dermatophagoides pteronyssinus.
  95. pmc Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides
    Rebecca Guza
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:22601-10. 2009
    ..adducts induced by tobacco-specific nitrosamines are repaired by O(6)-alkylguanine DNA alkyltransferase (AGT), which transfers the O(6)-alkyl group from the damaged base to a cysteine residue within the protein...
  96. ncbi Circadian variation in O6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects
    C Marchenay
    INSERM U484, Clermont Ferrand, France
    Int J Cancer 91:60-6. 2001
    ..This highly mutagenic lesion can be repaired by O6-alkylguanine-DNA alkyltransferase (AGT), which removes the alkyl group by accepting it to the cysteine residue of its active site...
  97. ncbi [The analysis of smooth pursuit test in unilateral vestibular peripheral vertigo]
    Jing Bi
    First Center Clinic College, Tianjin Medical University, Tianjin, 300070, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24:8-10, 15. 2010
    To analyze the result of smooth pursuit test (SPT) in unilateral vestibular peripheral vertigo and investigate its influencing factors.
  98. doi Comparison of wheat and rye flour solutions for skin prick testing: a multi-centre study (Stad 1)
    V van Kampen
    BGFA Research Institute of Occupational Medicine, Ruhr University, Bochum, Germany
    Clin Exp Allergy 39:1896-902. 2009
    Skin prick testing (SPT) is the basic method for diagnosing IgE-mediated allergies. However, skin reactivity is related to the quality of allergen extracts, which are often poorly defined for occupational allergens.
  99. ncbi Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer
    R L Schilsky
    Department of Medicine, Cancer Research Center and Committee on Clinical Pharmacology, University of Chicago, Illinois 60637, USA
    Clin Cancer Res 6:3025-31. 2000
    O6-benzylguanine (BG) is a potent inactivator of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT) that enhances sensitivity to nitrosoureas in tumor cell lines and tumor-bearing animals...
  100. ncbi Lipid composition of Ruditapes philippinarum spat: effect of ration and diet quality
    M J Fernández-Reiriz
    Consejo Superior Investigaciones Cientificas, Instituto de Investigaciones Marinas, Vigo, Spain
    Comp Biochem Physiol B Biochem Mol Biol 144:229-37. 2006
    ..of microalgal and commercial flour diets on the lipid classes and fatty acids of Ruditapes philippinarum spat. Aspects of the nutritional role of the diets and the feeding ration are discussed with regard to previously ..
  101. ncbi The prevalence of latex sensitisation and allergy in Danish atopic children. Evaluation of diagnostic methods
    Vagn Braendholt Jensen
    Department of Paediatrics, Gentofte University Hospital, Copenhagen, Denmark
    Dan Med Bull 49:260-2. 2002
    ..All over the world natural rubber allergy is reported to be responsible for a wide spectrum of allergic symptoms ranging from mild rhinitis to severe anaphylaxis...

Research Grants98

  1. Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender
    Donald E Kohan; Fiscal Year: 2010
    Common genetic variation in the angiotensinogen (AGT) gene predisposes to essential hypertension (EH) and increased plasma AGT in humans...
  2. Angiotensin: A Link Between Obesity and Hypertension
    Lisa A Cassis; Fiscal Year: 2010
    ..Angiotensinogen (AGT), angiotensin type 1a receptors (AT1aR), and ACE2 are three components of the RAS that were regulated specifically ..
  3. SIGNIFICANCE OF ANGIOTENSINOGEN VARIANTS IN HYPERTENSION
    CURT SIGMUND; Fiscal Year: 2009
    ..Angiotensinogen (AGT), the initiating substrate of the system has been genetically linked to hypertension...
  4. SIGNIFICANCE OF ANGIOTENSINOGEN VARIANTS IN HYPERTENSION
    CURT DANIEL SIGMUND; Fiscal Year: 2010
    ..Angiotensinogen (AGT), the initiating substrate of the system has been genetically linked to hypertension...
  5. Mapping for Specialized Domains for FCeRI Signaling & Internalization
    Bridget S Wilson; Fiscal Year: 2010
    ..Single particle tracking (SPT) with multiple colors of monomeric IgE-quantum dot probes will reveal consequences of this disruption for receptor ..
  6. Probiotic-Induced Elimination of Oxalate to Treat Hyperoxaluria Associated with P
    Marguerite Hatch; Fiscal Year: 2010
    ..1) In the genetic disease of Primary Hyperoxaluria Type 1 (PH1), an increased endogenous production of oxalate, due to a deficiency of the liver enzyme alanine-glyoxylate ..
  7. Transcriptional Regulation of Angiotensinogen Gene
    Ashok Kumar; Fiscal Year: 2010
    ..Previous studies have suggested that: (a) angiotensinogen (AGT) gene locus is associated with human essential hypertension, (b) variant -6A of the AGT gene is associated with ..
  8. Transcriptional Regulation of Angiotensinogen Gene
    Ashok Kumar; Fiscal Year: 2009
    ..Previous studies have suggested that: (a) angiotensinogen (AGT) gene locus is associated with human essential hypertension, (b) variant -6A of the AGT gene is associated with ..
  9. The Angiotensinogen Gene and Human Hypertension
    Lynn Jorde; Fiscal Year: 2006
    ..Many, but not all, studies have shown that variants of the angiotensinogen gene (AGT) affect the risk of hypertension, but association studies conducted to date have been compromised by genetic ..
  10. The Angiotensinogen Gene and Human Hypertension
    Lynn Jorde; Fiscal Year: 2003
    ..Many, but not all, studies have shown that variants of the angiotensinogen gene (AGT) affect the risk of hypertension, but association studies conducted to date have been compromised by genetic ..
  11. ANGIOTENSINOGEN AND HUMAN HYPERTENSION
    Jean Marc Lalouel; Fiscal Year: 1999
    ..of patients form Utah and France, they have obtained evidence of genetic linkage between the angiotensinogen gene (AGT) and hypertension, demonstrated association of a common molecular variant of the gene (T235) with the disease, and ..
  12. PATHOGENESIS OF RADIATION-INDUCED KIDNEY INJURY
    Michael Robbins; Fiscal Year: 2004
    ..tissue inhibitor of metalloproteinases-2 (TIMP-2) matrix metalloproteinase-2 (MMP-2), TGF-B and angiotensinogen (AGT, precursor of Ang II)...
  13. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2009
    Primary hyperoxaluria type I (PH1) is an autosomal recessive disease caused by excessive oxalate production by hepatocytes due to peroxisomal alanine-glyoxylate aminotransferase (AGT) deficiency, leading to increased conversion of ..
  14. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
    Primary hyperoxaluria type I (PH1) is an autosomal recessive disease caused by excessive oxalate production by hepatocytes due to peroxisomal alanine-glyoxylate aminotransferase (AGT) deficiency, leading to increased conversion of ..
  15. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    ..affords us a unique opportunity to evaluate PAT1 function/activity in the setting of Primary Hyperoxaluria, type1 (PH1), with and without Oxalobacter colonization...
  16. SIGNIFICANCE OF ANGIOTENSINOGEN VARIANTS IN HYPERTENSION
    CURT SIGMUND; Fiscal Year: 2003
    ..only compelling evidence supporting the linkage of a human gene with essential hypertension is for angiotensinogen (AGT)...
  17. SIGNIFICANCE OF ANGIOTENSINOGEN VARIANTS IN HYPERTENSION
    CURT SIGMUND; Fiscal Year: 2007
    ..of the mouse genome can be used to test the physiological significance of genetic variants in the human AGT genes, and its interaction with environmental and genetic stressors...
  18. Renal Function Derangements in Hypertension
    LUIS GABRIEL NAVAR; Fiscal Year: 2010
    ..Ang II, AT1 receptor mediated uptake of Ang II into endosomes and augmentation of intrarenal angiotensinogen (AGT) and tubular renin mRNA and protein via AT1 receptor mechanisms...
  19. TARGETED ABLATION OF BRAIN ANGIOTENSINGERGIC SYSTEMS
    ROBIN DAVISSON; Fiscal Year: 2004
    ..Evidence suggests that the only known precursor of Ang II, angiotensinogen (AGT) is localized to both astrocytes and neurons in the brain...
  20. Analysis of PH1-associated alanine:glyoxylate aminotranferase (AGT) using yeast
    Chandra Tucker; Fiscal Year: 2009
    Primary Hyperoxaluria type I (PH1) is a severe kidney stone disease caused by deficiency of the protein alanine: glyoxylate aminotransferase (AGT)...
  21. Hydroxproline Catabolism and Hyperoxaluria
    W TODD contact LOWTHER; Fiscal Year: 2010
    Primary hyperoxaluria types I and 2 (PH1 and PH2) are characterized by an inability to efficiently metabolize glyoxylate as a consequence of functional defects in alanine-glyoxylate aminotransferase and glyoxylate reductase, ..
  22. Analysis of PH1-associated alanine:glyoxylate aminotranferase (AGT) using yeast
    Chandra L Tucker; Fiscal Year: 2010
    Primary Hyperoxaluria type I (PH1) is a severe kidney stone disease caused by deficiency of the protein alanine: glyoxylate aminotransferase (AGT)...
  23. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1993
    ....
  24. FUNCTIONAL CHARACTERIZATION OF AGT GENETIC POLYMORPHISM
    Jun yan Hong; Fiscal Year: 2001
    ..Human O6-alkylguanine-DNA alkyltransferase (AGT, EC 2.1.1...
  25. Structural Biochemistry of DNA Dealkylation
    John A Tainer; Fiscal Year: 2010
    ..Our efforts to date have helped elucidate the structural chemistry for human direct reversal proteins AGT (O6- alkylguanine-DNA-alkyltransferases) and ABH3 (the dealkylation dioxygenase AlkB homolog 3) and support their ..
  26. Structural Biochemistry of DNA Dealkylation
    John Tainer; Fiscal Year: 2009
    ..Our efforts to date have helped elucidate the structural chemistry for human direct reversal proteins AGT (O6- alkylguanine-DNA-alkyltransferases) and ABH3 (the dealkylation dioxygenase AlkB homolog 3) and support their ..
  27. Structural Biochemistry of DNA Dealkylation
    John A Tainer; Fiscal Year: 2010
    ..Our efforts to date have helped elucidate the structural chemistry for human direct reversal proteins AGT (O6- alkylguanine-DNA-alkyltransferases) and ABH3 (the dealkylation dioxygenase AlkB homolog 3) and support their ..
  28. Structural Biochemistry of DNA Dealkylation
    John Tainer; Fiscal Year: 2009
    ..Our efforts to date have helped elucidate the structural chemistry for human direct reversal proteins AGT (O6- alkylguanine-DNA-alkyltransferases) and ABH3 (the dealkylation dioxygenase AlkB homolog 3) and support their ..
  29. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..of guanine and thymine residues by the alkylating agents, by the repair protein O6 alkyl-DNA alkyltrasferase (AGT). AGT repairs the lesions by transferring the alkyl groups from the modified DNA to a cysteine in its active site...
  30. Deciphering T-box gene-dependent mesoderm development with synthetic probes
    James K Chen; Fiscal Year: 2010
    ..Tbx) transcription factors work in concert to pattern the mesoderm lineage, including no tail (ntl), spadetail (spt), and tbx6...
  31. AGT DEPLETION FOR THERAPY OF CNS TUMORS
    Jennifer Quinn; Fiscal Year: 2004
    ..to alkylnitrosourea and methylator therapy is the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT). AGT removes chlorethylation or methylation damage from the O6-position of guanine prior to cell injury and death...
  32. Development of Anticancer 1,2-Bis(sulfonyl)hydrazines
    Alan Sartorelli; Fiscal Year: 2009
    ..Methyl isocyanate functions in part by inhibiting O6-alkylguanine-DNA alkyltransferase activity (AGT), a major mechanism of resistance to agents such as Cloretazine, which alkylate the O-6 position of guanine in DNA...
  33. Development of Anticancer 1,2-Bis(sulfonyl)hydrazines
    Alan Sartorelli; Fiscal Year: 2007
    ..Methyl isocyanate functions in part by inhibiting O6-alkylguanine-DNA alkyltransferase activity (AGT), a major mechanism of resistance to agents such as Cloretazine, which alkylate the O-6 position of guanine in DNA...
  34. Hypoxia-Activated O6-Benzylguanine Prodrugs
    ALAN CLAYTON SARTORELLI; Fiscal Year: 2010
    ..of DNA guanine which leads to a G-C crosslink, is susceptible to repair by O6-alkylguanine-DNA alkyltransferase (AGT), a protein that transfers alkyl and methyl groups from the O-6 position of guanine to the AGT molecule...
  35. 2/2-Treatment of Adolescent Bulimics
    Daniel le Grange; Fiscal Year: 2009
    ..between specific treatments (CBT-A and FBT-BN) compared to a non-specific treatment (Supportive psychotherapy - SPT) in order to examine nonspecific treatment effects (passage of time and nonspecific therapeutic influences)...
  36. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    ..are capable of interfering the repair of O6-mG by O6-alkylguanine-DNA alkyltransferase (AGT)...