alanine glyoxylate aminotransferase

Summary

Gene Symbol: alanine glyoxylate aminotransferase
Description: alanine--glyoxylate and serine--pyruvate aminotransferase
Alias: AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6, serine--pyruvate aminotransferase, L-alanine: glyoxylate aminotransferase 1, alanine-glyoxylate aminotransferase, hepatic peroxisomal alanine:glyoxylate aminotransferase
Species: human

Top Publications

  1. Cellini B, Montioli R, Paiardini A, Lorenzetto A, Maset F, Bellini T, et al. Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I. Proc Natl Acad Sci U S A. 2010;107:2896-901 pubmed publisher
    G41 is an interfacial residue located within the alpha-helix 34-42 of alanine:glyoxylate aminotransferase (AGT)...
  2. Monico C, Olson J, Milliner D. Implications of genotype and enzyme phenotype in pyridoxine response of patients with type I primary hyperoxaluria. Am J Nephrol. 2005;25:183-8 pubmed
    Marked hyperoxaluria due to liver-specific deficiency of alanine:glyoxylate aminotransferase activity (AGT) characterizes type I primary hyperoxaluria (PHI)...
  3. Santana A, Salido E, Torres A, Shapiro L. Primary hyperoxaluria type 1 in the Canary Islands: a conformational disease due to I244T mutation in the P11L-containing alanine:glyoxylate aminotransferase. Proc Natl Acad Sci U S A. 2003;100:7277-82 pubmed
    Primary hyperoxaluria type 1 (PH1) is an inborn error of metabolism resulting from a deficiency of alanine:glyoxylate aminotransferase (AGXT; EC 2.6.1.44)...
  4. Yuen Y, Lai C, Tong G, Wong P, Wong F, Mak S, et al. Novel mutations of the AGXT gene causing primary hyperoxaluria type 1. J Nephrol. 2004;17:436-40 pubmed
    ..is due to a functional defect of the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT)...
  5. Mesa Torres N, Fabelo Rosa I, Riverol D, Yunta C, Albert A, Salido E, et al. The role of protein denaturation energetics and molecular chaperones in the aggregation and mistargeting of mutants causing primary hyperoxaluria type I. PLoS ONE. 2013;8:e71963 pubmed publisher
    ..type I (PH1) is a conformational disease which result in the loss of alanine:glyoxylate aminotransferase (AGT) function...
  6. Nishiyama K, Funai T, Katafuchi R, Hattori F, Onoyama K, Ichiyama A. Primary hyperoxaluria type I due to a point mutation of T to C in the coding region of the serine:pyruvate aminotransferase gene. Biochem Biophys Res Commun. 1991;176:1093-9 pubmed
    ..aminotransferase) were obtained from a cDNA library constructed from the liver of a primary hyperoxaluria type I (PH1) case in which the SPT activity was approximately one-hundredth that in control liver...
  7. Albert A, Yunta C, Arranz R, Peña A, Salido E, Valpuesta J, et al. Structure of GroEL in complex with an early folding intermediate of alanine glyoxylate aminotransferase. J Biol Chem. 2010;285:6371-6 pubmed publisher
    Primary hyperoxaluria type 1 is a rare autosomal recessive disease caused by mutations in the alanine glyoxylate aminotransferase gene (AGXT)...
  8. Oppici E, Fodor K, Paiardini A, Williams C, Voltattorni C, Wilmanns M, et al. Crystal structure of the S187F variant of human liver alanine: glyoxylate [corrected] aminotransferase associated with primary hyperoxaluria type I and its functional implications. Proteins. 2013;81:1457-65 pubmed publisher
    ..Ser187, a residue located far from the active site of human liver peroxisomal alanine:glyoxylate aminotransferase (AGT), by Phe gives rise to a variant associated with primary hyperoxaluria type I...
  9. Lorenzo V, Alvarez A, Torres A, Torregrosa V, Hernandez D, Salido E. Presentation and role of transplantation in adult patients with type 1 primary hyperoxaluria and the I244T AGXT mutation: Single-center experience. Kidney Int. 2006;70:1115-9 pubmed
    Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder characterized by allelic and clinical heterogeneity...

More Information

Publications77

  1. Minatogawa Y, Tone S, Allsop J, Purdue P, Takada Y, Danpur C, et al. A serine-to-phenylalanine substitution leads to loss of alanine:glyoxylate aminotransferase catalytic activity and immunoreactivity in a patient with primary hyperoxaluria type 1. Hum Mol Genet. 1992;1:643-4 pubmed
  2. Purdue P, Allsop J, Isaya G, Rosenberg L, Danpure C. Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation. Proc Natl Acad Sci U S A. 1991;88:10900-4 pubmed
    ..disease is associated with a unique protein sorting defect in which hepatic L-alanine:glyoxylate aminotransferase (AGT; EC 2.6.1.44), which is normally peroxisomal, is mistargeted to mitochondria...
  3. Montioli R, Fargue S, Lewin J, Zamparelli C, Danpure C, Borri Voltattorni C, et al. The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase. Int J Biochem Cell Biol. 2012;44:536-46 pubmed publisher
    Alanine:glyoxylate aminotransferase (AGT) is a pyridoxal-phosphate (PLP)-dependent enzyme. Its deficiency causes the hereditary kidney stone disease primary hyperoxaluria type 1...
  4. Oppici E, Roncador A, Montioli R, Bianconi S, Cellini B. Gly161 mutations associated with Primary Hyperoxaluria Type I induce the cytosolic aggregation and the intracellular degradation of the apo-form of alanine:glyoxylate aminotransferase. Biochim Biophys Acta. 2013;1832:2277-88 pubmed publisher
    ..rare disorder of metabolism due to inherited mutations on liver peroxisomal alanine:glyoxylate aminotransferase (AGT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme whose deficiency causes the deposition of calcium oxalate ..
  5. Amoroso A, Pirulli D, Florian F, Puzzer D, Boniotto M, Crovella S, et al. AGXT gene mutations and their influence on clinical heterogeneity of type 1 primary hyperoxaluria. J Am Soc Nephrol. 2001;12:2072-9 pubmed
    Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder that is caused by a deficiency of alanine: glyoxylate aminotransferase (AGT), which is encoded by a single copy gene (AGXT)...
  6. Nagara M, Tiar A, Ben Halim N, Ben Rhouma F, Messaoud O, Bouyacoub Y, et al. Mutation spectrum of primary hyperoxaluria type 1 in Tunisia: implication for diagnosis in North Africa. Gene. 2013;527:316-20 pubmed publisher
    ..Mutations in the AGXT gene, encoding the liver-specific enzyme alanine glyoxylate aminotransferase, are responsible for the disease...
  7. Zhang X, Roe S, Hou Y, Bartlam M, Rao Z, Pearl L, et al. Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1. J Mol Biol. 2003;331:643-52 pubmed
    A deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase (AGT) is responsible for the potentially lethal hereditary kidney stone disease primary hyperoxaluria type 1 (PH1)...
  8. Purdue P, Takada Y, Danpure C. Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1. J Cell Biol. 1990;111:2341-51 pubmed
    We have previously shown that in some patients with primary hyperoxaluria type 1 (PH1), disease is associated with mistargeting of the normally peroxisomal enzyme alanine/glyoxylate aminotransferase (AGT) to mitochondria (Danpure, C.J...
  9. Oppici E, Montioli R, Lorenzetto A, Bianconi S, Borri Voltattorni C, Cellini B. Biochemical analyses are instrumental in identifying the impact of mutations on holo and/or apo-forms and on the region(s) of alanine:glyoxylate aminotransferase variants associated with primary hyperoxaluria type I. Mol Genet Metab. 2012;105:132-40 pubmed publisher
    ..caused by mutations in the human AGXT gene encoding liver peroxisomal alanine:glyoxylate aminotransferase (AGT), a pyridoxal 5'-phosphate (PLP) dependent enzyme...
  10. Coulter Mackie M, Lian Q. Partial trypsin digestion as an indicator of mis-folding of mutant alanine:glyoxylate aminotransferase and chaperone effects of specific ligands. Study of a spectrum of missense mutants. Mol Genet Metab. 2008;94:368-74 pubmed publisher
    ..aminotransferase (AGT) is a liver peroxisomal enzyme whose deficiency results in primary hyperoxaluria type 1 (PH1). More than 75 PH1 mutations are now documented in the AGT gene (AGXT), of which about 50% are missense...
  11. Coulter Mackie M, Lian Q, Wong S. Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor. Protein Expr Purif. 2005;41:18-26 pubmed
    Alanine:glyoxylate aminotransferase-1 (AGT) is a human liver peroxisomal enzyme whose deficiency results in, primary hyperoxaluria type 1 (PH1), a fatal metabolic disease...
  12. Rumsby G, Williams E, Coulter Mackie M. Evaluation of mutation screening as a first line test for the diagnosis of the primary hyperoxalurias. Kidney Int. 2004;66:959-63 pubmed
    ..1 (PH1) and primary hyperoxaluria type 2 (PH2) requires the measurement of alanine:glyoxylate aminotransferase (AGT) and glyoxylate reductase (GR) activities, respectively, in a liver biopsy...
  13. Purdue P, Lumb M, Fox M, Griffo G, Hamon Benais C, Povey S, et al. Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase. Genomics. 1991;10:34-42 pubmed
    ..the isolation of a genomic clone encoding human liver-specific peroxisomal alanine:glyoxylate aminotransferase (AGT, EC 2.6.1.44), the deficient enzyme in primary hyperoxaluria type 1 (PH1) (P. E. Purdue, Y. Takada, and C. J...
  14. Nishiyama K, Berstein G, Oda T, Ichiyama A. Cloning and nucleotide sequence of cDNA encoding human liver serine-pyruvate aminotransferase. Eur J Biochem. 1990;194:9-18 pubmed
  15. van Woerden C, Groothoff J, Wijburg F, Annink C, Wanders R, Waterham H. Clinical implications of mutation analysis in primary hyperoxaluria type 1. Kidney Int. 2004;66:746-52 pubmed
    Primary hyperoxaluria type 1 (PH1) is an inborn error of glyoxylate metabolism with an extensive clinical and genetic heterogeneity...
  16. Danpure C, Jennings P. Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I. FEBS Lett. 1986;201:20-4 pubmed
    ..This enzyme deficiency explains most of the biochemical characteristics of the disease and means that primary hyperoxaluria type I should be added to the rather select list of peroxisomal disorders. ..
  17. Takada Y, Kaneko N, Esumi H, Purdue P, Danpure C. Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon. Biochem J. 1990;268:517-20 pubmed
    ..These data suggest that the targeting defect in primary hyperoxaluria type 1, in which AGT1 is diverted from the peroxisomes to the mitochondria, could be due to a point mutation that reintroduces all or ..
  18. Cellini B, Montioli R, Bianconi S, López Alonso J, Voltattorni C. Construction, purification and characterization of untagged human liver alanine-glyoxylate aminotransferase expressed in Escherichia coli. Protein Pept Lett. 2008;15:153-9 pubmed
    ..Alanine:glyoxylate aminotransferase (AGT) is a peroxisomal pyridoxal 5'-phosphate (PLP) dependent enzyme which catalyzes the transamination of alanine and ..
  19. Salido E, Li X, Lu Y, Wang X, Santana A, Roy Chowdhury N, et al. Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer. Proc Natl Acad Sci U S A. 2006;103:18249-54 pubmed
    ..Hepatic expression of human AGT1, the protein encoded by AGXT, by adenoviral vector-mediated gene transfer in Agxt(-/-) mice normalized urinary ..
  20. Danpure C. Molecular etiology of primary hyperoxaluria type 1: new directions for treatment. Am J Nephrol. 2005;25:303-10 pubmed
    Primary hyperoxaluria type 1 (PH1) is a rare autosomal-recessive disorder caused by a deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase (AGT)...
  21. Basmaison O, Rolland M, Cochat P, Bozon D. Identification of 5 novel mutations in the AGXT gene. Hum Mutat. 2000;15:577 pubmed
    ..Their consequence is always a lack of enzymatic activity of the Alanine-Glyoxylate Aminotransferase (AGT); for 4 of them, we were able to deduce that they were associated to the absence of AGT protein...
  22. Fodor K, Wolf J, Erdmann R, Schliebs W, Wilmanns M. Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1. PLoS Biol. 2012;10:e1001309 pubmed publisher
    ..We discuss how the knowledge of the molecular parameters for alanine-glyoxylate aminotransferase required for peroxisomal translocation could become useful for improved hyperoxaluria type 1 treatment. ..
  23. von Schnakenburg C, Rumsby G. Primary hyperoxaluria type 1: a cluster of new mutations in exon 7 of the AGXT gene. J Med Genet. 1997;34:489-92 pubmed
    ..Enzyme studies in these patients showed that AGT catalytic activity was either very low or absent and that little or no immunoreactive protein was present...
  24. Huber P, Birdsey G, Lumb M, Prowse D, Perkins T, Knight D, et al. Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus. J Biol Chem. 2005;280:27111-20 pubmed
    Although human alanine:glyoxylate aminotransferase (AGT) is imported into peroxisomes by a Pex5p-dependent pathway, the properties of its C-terminal tripeptide (KKL) are unlike those of any other type 1 peroxisomal targeting sequence (..
  25. Danpure C, Purdue P, Fryer P, Griffiths S, Allsop J, Lumb M, et al. Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation. Am J Hum Genet. 1993;53:417-32 pubmed
    ..disease caused by a deficiency of the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT). Three unrelated PH1 patients, who possess a novel complex phenotype, are described...
  26. Williams E, Rumsby G. Selected exonic sequencing of the AGXT gene provides a genetic diagnosis in 50% of patients with primary hyperoxaluria type 1. Clin Chem. 2007;53:1216-21 pubmed
    Definitive diagnosis of primary hyperoxaluria type 1 (PH1) requires analysis of alanine:glyoxylate aminotransferase (AGT) activity in the liver...
  27. Cellini B, Montioli R, Paiardini A, Lorenzetto A, Voltattorni C. Molecular Insight into the Synergism between the Minor Allele of Human Liver Peroxisomal Alanine:Glyoxylate Aminotransferase and the F152I Mutation. J Biol Chem. 2009;284:8349-58 pubmed publisher
    Human liver peroxisomal alanine:glyoxylate aminotransferase (AGT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that converts glyoxylate into glycine...
  28. Knott T, Birdsey G, Sinclair K, Gallagher I, Purdue P, Danpure C. The peroxisomal targeting sequence type 1 receptor, Pex5p, and the peroxisomal import efficiency of alanine:glyoxylate aminotransferase. Biochem J. 2000;352 Pt 2:409-18 pubmed
    ..in which the cytosolic levels of two peroxisomal proteins, catalase and alanine:glyoxylate aminotransferase (AGT), are much higher than those found in human (Homo sapiens) hepatocytes, for example...
  29. Cellini B, Lorenzetto A, Montioli R, Oppici E, Voltattorni C. Human liver peroxisomal alanine:glyoxylate aminotransferase: Different stability under chemical stress of the major allele, the minor allele, and its pathogenic G170R variant. Biochimie. 2010;92:1801-11 pubmed publisher
    ..1 M urea. These biochemical results are discussed in the light of the characteristics of the enzymatic phenotype of PH1 patients bearing G170R mutation in AGT-Mi and the positive response of these patients to pyridoxine treatment.
  30. Purdue P, Lumb M, Allsop J, Minatogawa Y, Danpure C. A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1. Genomics. 1992;13:215-8 pubmed
    ..AGT; HGMW-approved symbol for the gene--AGXT) cDNA from the liver of a primary hyperoxaluria type 1 (PH1) patient who had normal levels of hepatic peroxisomal immunoreactive AGT protein, but no AGT catalytic activity...
  31. Pey A, Salido E, Sanchez Ruiz J. Role of low native state kinetic stability and interaction of partially unfolded states with molecular chaperones in the mitochondrial protein mistargeting associated with primary hyperoxaluria. Amino Acids. 2011;41:1233-45 pubmed publisher
    The G170R variant of the alanine:glyoxylate aminotransferase (AGT) is the most common pathogenic allele associated to primary hyperoxaluria type I (PH1), leading to mitochondrial mistargeting when combined with the P11L and I340M ..
  32. Fargue S, Lewin J, Rumsby G, Danpure C. Four of the most common mutations in primary hyperoxaluria type 1 unmask the cryptic mitochondrial targeting sequence of alanine:glyoxylate aminotransferase encoded by the polymorphic minor allele. J Biol Chem. 2013;288:2475-84 pubmed publisher
    The gene encoding the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT, EC. 2.6.1.44) exists as two common polymorphic variants termed the "major" and "minor" alleles...
  33. Monico C, Rossetti S, Schwanz H, Olson J, Lundquist P, Dawson D, et al. Comprehensive mutation screening in 55 probands with type 1 primary hyperoxaluria shows feasibility of a gene-based diagnosis. J Am Soc Nephrol. 2007;18:1905-14 pubmed
    Mutations in AGXT, a locus mapped to 2q37.3, cause deficiency of liver-specific alanine:glyoxylate aminotransferase (AGT), the metabolic error in type 1 primary hyperoxaluria (PH1)...
  34. Cellini B, Bertoldi M, Montioli R, Paiardini A, Borri Voltattorni C. Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications. Biochem J. 2007;408:39-50 pubmed
    Human hepatic peroxisomal AGT (alanine:glyoxylate aminotransferase) is a PLP (pyridoxal 5'-phosphate)-dependent enzyme whose deficiency causes primary hyperoxaluria Type I, a rare autosomal recessive disorder...
  35. Coulter Mackie M, Lian Q. Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations. Mol Genet Metab. 2006;89:349-59 pubmed
    ..aminotransferase (AGT) is a liver peroxisomal enzyme, deficiency of which results in primary hyperoxaluria type 1 (PH1). More than 65 PH1-related mutations are now documented in the AGT gene (AGXT), of which about 50% are missense...
  36. Lumb M, Danpure C. Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations. J Biol Chem. 2000;275:36415-22 pubmed
    The autosomal recessive disorder primary hyperoxaluria type 1 (PH1) is caused by a deficiency of the liver-specific pyridoxal-phosphate-dependent enzyme alanine:glyoxylate aminotransferase (AGT)...
  37. Hopper E, Pittman A, Fitzgerald M, Tucker C. In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase. J Biol Chem. 2008;283:30493-502 pubmed publisher
    ..type I is a severe kidney stone disease caused by mutations in the protein alanine:glyoxylate aminotransferase (AGT)...
  38. Williams E, Acquaviva C, Amoroso A, Chevalier F, Coulter Mackie M, Monico C, et al. Primary hyperoxaluria type 1: update and additional mutation analysis of the AGXT gene. Hum Mutat. 2009;30:910-7 pubmed publisher
    ..inherited disorder of glyoxylate metabolism arising from a deficiency of the alanine:glyoxylate aminotransferase (AGT) enzyme, encoded by the AGXT gene...
  39. Yu S, Chang Y, Chen Y. Deletion of ADA2 Increases Antifungal Drug Susceptibility and Virulence in Candida glabrata. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Ada2, a component serving as a transcription adaptor of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex, is required for antifungal drug tolerance and virulence in C...
  40. Cruz Neves S, Shirosaki Y, Miyazaki T, Hayakawa S. Characterization and degradation study of chitosan-siloxane hybrid microspheres synthesized using a microfluidic approach. Mater Sci Eng C Mater Biol Appl. 2017;81:571-579 pubmed publisher
    ..The microspheres incubated at pH7.4 extended the lowest weight loss (27%-32%), whereas those incubated at pH1.7 and pH5.4 showed greater weight losses of 43-59% and 69-77%, respectively...
  41. Jana S, Banerjee A, Sen K, Maiti S. Gelatin-carboxymethyl tamarind gum biocomposites: In vitro characterization & anti-inflammatory pharmacodynamics. Mater Sci Eng C Mater Biol Appl. 2016;69:478-85 pubmed publisher
    ..CTG in IPN structures suppressed the drug release rate in HCl solution (pH1.2); however extended the same in phosphate buffer solution (pH6.8)...
  42. Zhang K, Liu J, You X, Kong P, Song Y, Cao L, et al. P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice. Neurosci Lett. 2016;613:60-5 pubmed publisher
    ..activity in open filed test (OFT) and the preference for sucrose was also recovered in sucrose preference test (SPT) with Chr preconditioning...
  43. Sanchiz A, Cuadrado C, Diéguez M, Ballesteros I, Rodriguez J, Crespo J, et al. Thermal processing effects on the IgE-reactivity of cashew and pistachio. Food Chem. 2018;245:595-602 pubmed publisher
    ..IgE-western blot and IgE-ELISA were complemented by Skin Prick Testing (SPT) and mediator release assay to determine the IgE cross-linking capability of treated and untreated samples...
  44. Li Y, Cheng K, Liu K, Peng W, Cheng J, Niu H. Telmisartan Activates PPAR? to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in Mice. Sci Rep. 2017;7:14021 pubmed publisher
    ..of grooming and rearing in open filed test (OFT) and the decreased sucrose consumption in sucrose preference test (SPT) compared with the paradigms...
  45. Cao J, Yang B, Wang Y, Wei C, Wang H, Li S. Polymer brush hexadecyltrimethylammonium bromide (CTAB) modified poly (propylene-g-styrene sulphonic acid) fiber (ZB-1): CTAB/ZB-1 as a promising strategy for improving the dissolution and physical stability of poorly water-soluble drugs. Mater Sci Eng C Mater Biol Appl. 2017;80:282-295 pubmed publisher
    ..In vitro dissolution in pure water and pH1.2 HCl media with/without 0.1% sodium dodecyl sulfate (SDS) was tested...
  46. Gong M, Huai Z, Song H, Cui L, Guo Q, Shao J, et al. Effects of maternal exposure to bisphenol AF on emotional behaviors in adolescent mice offspring. Chemosphere. 2017;187:140-146 pubmed publisher
    ..behaviors, assessed by open field test (OFT), novelty-suppressed feeding test (NSF), sucrose preference test (SPT), tail suspension test (TST) and forced swimming test (FST). In female adolescent offspring, BPAF exposure at 0...
  47. Barberini S, Della Rocca G, Danti R, Zanoni D, Mori B, Ariano R, et al. Different allergenicity of pollen extracts of three Mediterranean cypress species accounted for cytological observations. Eur Ann Allergy Clin Immunol. 2015;47:149-55 pubmed
    ..profile through SDS PAGE analysis and to evaluate their allergenic potential through EAST inhibition assays and SPT. Pollen grain composition was evaluated using a cytochemical approach with optical microscopy...
  48. Morato M, Correia Costa L, Sousa T, Cosme D, Schaefer F, Areias J, et al. Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children. Pediatr Nephrol. 2017;32:1411-1422 pubmed publisher
    We aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender...
  49. ELBadawy N, Abdel Latif R, El Hady H. Association between SERPINB2 Gene Expression by Real Time PCR in Respiratory Epithelial Cells and Atopic Bronchial Asthma Severity. Egypt J Immunol. 2017;24:165-181 pubmed
    ..The patients were subjected to skin prick test (SPT) by commonly encountered aeroallergens and pulmonary function tests...
  50. Fargue S, Knight J, Holmes R, Rumsby G, Danpure C. Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay. Biochim Biophys Acta. 2016;1862:1055-62 pubmed publisher
    ..of the liver-specific, peroxisomal, pyridoxal-phosphate-dependent enzyme, alanine:glyoxylate aminotransferase (AGT). One third of PH1 patients, particularly those expressing the p...
  51. Othman A, Benghozi R, Alecu I, Wei Y, Niesor E, von Eckardstein A, et al. Fenofibrate lowers atypical sphingolipids in plasma of dyslipidemic patients: A novel approach for treating diabetic neuropathy?. J Clin Lipidol. 2015;9:568-75 pubmed publisher
    ..is the first step in the de novo formation of sphingolipids and catalyzed by the serine-palmitoyltransferase (SPT)...
  52. Eguchi K, Kashima H, Yokota A, Miura K, Yamaoka Endo M, Hirano H, et al. Acute effect of oral sensation of sweetness on celiac artery blood flow and gastric myoelectrical activity in humans. Auton Neurosci. 2016;197:41-5 pubmed publisher
    ..The fluid was then spat out, and subjects remained at rest for a further 10min...
  53. Huang W, Guo Y, Du W, Zhang X, Li A, Miao X. Global transcriptome analysis identifies differentially expressed genes related to lipid metabolism in Wagyu and Holstein cattle. Sci Rep. 2017;7:5278 pubmed publisher
    ..play a critical role. Protein-protein interaction network analysis showed EGR1, FOS, SERPINE1, AGT, MMP2 may have great impact on adipocyte differentiation and adipogenesis...
  54. Tse E, Belsham D. Palmitate induces neuroinflammation, ER stress, and Pomc mRNA expression in hypothalamic mHypoA-POMC/GFP neurons through novel mechanisms that are prevented by oleate. Mol Cell Endocrinol. 2018;472:40-49 pubmed publisher
    ..the increase in Pomc was dependent on palmitoyl-coA synthesis, but not de novo ceramide synthesis, as inhibition of SPT enhanced palmitate-induced Pomc expression, while methylpalmitate had no effect...
  55. Shahzad S, Ahmad S, Madiha S, Khaliq S, Liaquat L, Sadir S, et al. Dizocilpine induced psychosis-like behavior in rats: A possible animal model with full spectrum of schizophrenia. Pak J Pharm Sci. 2017;30:2423-2427 pubmed
    ..Negative symptoms were assessed by sucrose preference test (SPT) and social interaction test (SIT)...
  56. Liu Y, Peng J, Zhou Y, Cui Y. Comparison of atopy patch testing to skin prick testing for diagnosing mite-induced atopic dermatitis: a systematic review and meta-analysis. Clin Transl Allergy. 2017;7:41 pubmed publisher
    ..Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD.
  57. Hwang S, Seo S, Yoon H, Jung D, Baek H, Cho J, et al. Sleep Period Time Estimation Based on Electrodermal Activity. IEEE J Biomed Health Inform. 2017;21:115-122 pubmed publisher
    We proposed and tested a method to estimate sleep period time (SPT) using electrodermal activity (EDA) signals. Eight healthy subjects and six obstructive sleep apnea patients participated in the experiments...
  58. Montioli R, Oppici E, Dindo M, Roncador A, Gotte G, Cellini B, et al. Misfolding caused by the pathogenic mutation G47R on the minor allele of alanine:glyoxylate aminotransferase and chaperoning activity of pyridoxine. Biochim Biophys Acta. 2015;1854:1280-9 pubmed publisher
    ..Deficit of AGT causes Primary Hyperoxaluria Type 1 (PH1), an autosomal recessive rare disease...
  59. Berman T, Ben Ari M, Glasser T, Gish M, Inbar M. How goats avoid ingesting noxious insects while feeding. Sci Rep. 2017;7:14835 pubmed publisher
    ..If the goats picked up leaves with a webworm, they shook or discarded the leaf. They spat out webworms that entered their mouths, after detecting them by touch and taste...
  60. Ding N, Qi Q, Gu X, Zuo R, Liu J, Yang Z. De novo synthesis of sphingolipids is essential for decidualization in mice. Theriogenology. 2018;106:227-236 pubmed publisher
    ..rate of de novo synthesis pathway of sphingolipids is regulated by two key enzymes, serine palmitoyltransferase (SPT), and ketoreductase (Kds)...
  61. Gupta A, Singh M, Chakrabarti A, Mathew J, Rawat A. Correlation between fungal sensitisation in childhood persistent asthma and disease severity. Mycoses. 2017;: pubmed publisher
    ..Skin prick test (SPT) to 8 fungal antigens and total serum immunoglobulin E (IgE) were done...
  62. Arej N, Irani C, Abdelmassih Y, Slim E, Antoun J, Bejjani R, et al. Evaluation of allergic sensitization in Lebanese patients with allergic conjunctivitis. Int Ophthalmol. 2018;38:2041-2051 pubmed publisher
    ..Thirty-eight patients were assessed with SPT, and all had a positive result for at least one allergen...
  63. Liu J, Gong J, Nie G, He Y, Xiao B, Shen Y, et al. The mediating effects of childhood neglect on the association between schizotypal and autistic personality traits and depression in a non-clinical sample. BMC Psychiatry. 2017;17:352 pubmed publisher
    Autistic personality traits (APT) and schizotypal personality traits (SPT) are associated with depression. However, mediating factors within these relationships have not yet been explored...
  64. Martínez Montañés F, Lone M, Hsu F, Schneiter R. Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether. J Lipid Res. 2016;57:2040-2050 pubmed
    ..They are formed by the action of serine palmitoyl-CoA transferase (SPT), a complex of integral membrane proteins located in the endoplasmic reticulum...
  65. Miller L, Young J, Ray S, Wang G, Purohit S, Banik N, et al. Sphingosine Toxicity in EAE and MS: Evidence for Ceramide Generation via Serine-Palmitoyltransferase Activation. Neurochem Res. 2017;42:2755-2768 pubmed publisher
    ..followed by sphingosine accumulation in EAE spinal cord along with a stimulation of serine-palmitoyltransferase (SPT) activity was observed...
  66. Gamito P, Oliveira J, Alghazzawi D, Fardoun H, Rosa P, Sousa T, et al. The Art Gallery Test: A Preliminary Comparison between Traditional Neuropsychological and Ecological VR-Based Tests. Front Psychol. 2017;8:1911 pubmed publisher
    ..For this purpose, we have developed a preliminary study to test the Art Gallery Test (AGT) as an alternative to traditional neuropsychological testing...
  67. Haroush S, Moreno D, Silverman I, Turgeman A, Shneck R, Gelbstein Y. The Mechanical Behavior of HAVAR Foils Using the Small Punch Technique. Materials (Basel). 2017;10: pubmed publisher
    ..alloy foils following annealing, cold rolling, and subsequent heat treatments, using small punch testing (SPT), X-ray diffraction (XRD), and transmission-scanning electron microscopy (TEM)...
  68. Dallé E, Daniels W, Mabandla M. Fluvoxamine maleate normalizes striatal neuronal inflammatory cytokine activity in a Parkinsonian rat model associated with depression. Behav Brain Res. 2017;316:189-196 pubmed publisher
    ..The sucrose preference test (SPT) and the limb-use asymmetry test (cylinder test) were used to evaluate anhedonia and motor impairments respectively...