AKT2

Summary

Gene Symbol: AKT2
Description: v-akt murine thymoma viral oncogene homolog 2
Alias: HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, PKB beta, RAC-PK-beta, RAC-beta serine/threonine-protein kinase, murine thymoma viral (v-akt) homolog-2, protein kinase Akt-2, protein kinase B beta, rac protein kinase beta
Species: human

Top Publications

  1. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
  2. ncbi Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K
    M Sun
    Department of Pathology and Programs of Molecular Oncology and Drug Discovery, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Cancer Res 61:5985-91. 2001
  3. pmc Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
    Hanna Y Irie
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 171:1023-34. 2005
  4. ncbi Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
    Kristina S Kovacina
    Department of Molecular Pharmacology, Stanford University, California 94305 5174, USA
    J Biol Chem 278:10189-94. 2003
  5. pmc Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000520. 2009
  6. ncbi Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
    Y Mitsuuchi
    Molecular Oncology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, PA 19111, USA
    Oncogene 18:4891-8. 1999
  7. pmc Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma
    S P Staal
    Proc Natl Acad Sci U S A 84:5034-7. 1987
  8. pmc Akt2 kinase suppresses glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation
    Qiaojia Huang
    Department of Experimental Medicine, Fuzhou General Hospital Dongfang Hospital, 156 North Xi er Huan Road, Fuzhou City, Fujian Province 350025, China
    J Biol Chem 286:42211-20. 2011
  9. ncbi HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
    J Biol Chem 277:25195-202. 2002
  10. doi The Akt isoforms are present at distinct subcellular locations
    Stacey A Santi
    Tumor Biology Group, Northeastern Ontario Regional Cancer Centre, 41 Ramsey Lake Rd, Sudbury, ON, P3E 5J1, Canada
    Am J Physiol Cell Physiol 298:C580-91. 2010

Research Grants

  1. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2010
  2. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
  3. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
  4. Phosphoprotein CDP138 regulates glucose metabolism
    ZHEN YUE JIANG; Fiscal Year: 2013
  5. Phosphoprotein CDP138 regulates glucose metabolism
    ZHEN YUE JIANG; Fiscal Year: 2013
  6. SECOND MESSENGERS IN THE RETINA
    ROBERT E contact ANDERSON; Fiscal Year: 2011
  7. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
  8. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
  9. Akt-regulated pathways in platelet function
    Donna S Woulfe; Fiscal Year: 2011
  10. A Novel ROS Controlling Kinase
    EILEEN ANNE FRIEDMAN; Fiscal Year: 2010

Detail Information

Publications205 found, 100 shown here

  1. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
    ..Taken together, these results define a molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERalpha, and inhibition of tamoxifen-induced apoptotic regression...
  2. ncbi Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K
    M Sun
    Department of Pathology and Programs of Molecular Oncology and Drug Discovery, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Cancer Res 61:5985-91. 2001
    We have shown previously that the AKT2 pathway is essential for cell survival and important in malignant transformation...
  3. pmc Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
    Hanna Y Irie
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 171:1023-34. 2005
    ..receptor (IGF-IR) hyperstimulation induced hyperproliferation and antiapoptotic activities that were reversed by Akt2 down-regulation...
  4. ncbi Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
    Kristina S Kovacina
    Department of Molecular Pharmacology, Stanford University, California 94305 5174, USA
    J Biol Chem 278:10189-94. 2003
    ..of an inducible Akt was alone sufficient to stimulate the phosphorylation of PRAS40; and 3) cells lacking Akt1 and Akt2 exhibit a diminished ability to phosphorylate this protein...
  5. pmc Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000520. 2009
    ..In this review, we summarize past and present studies on HIV coreceptor signaling. We also discuss possible roles of coreceptor signaling in facilitating viral infection and pathogenesis...
  6. ncbi Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
    Y Mitsuuchi
    Molecular Oncology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, PA 19111, USA
    Oncogene 18:4891-8. 1999
    b>AKT2 is a serine/threonine kinase implicated in human ovarian and pancreatic cancers. AKT2 is activated by a variety of growth factors and insulin via phosphatidylinositol 3-kinase (PI3K)...
  7. pmc Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma
    S P Staal
    Proc Natl Acad Sci U S A 84:5034-7. 1987
    ..Two human homologues of the v-akt oncogene, AKT1 and AKT2, were cloned...
  8. pmc Akt2 kinase suppresses glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation
    Qiaojia Huang
    Department of Experimental Medicine, Fuzhou General Hospital Dongfang Hospital, 156 North Xi er Huan Road, Fuzhou City, Fujian Province 350025, China
    J Biol Chem 286:42211-20. 2011
    ..Here we detected a 36-kDa protein that was co-immunoprecipitated with protein kinase Bβ (Akt2) in OVCAR-3 ovarian cancer cells...
  9. ncbi HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
    J Biol Chem 277:25195-202. 2002
    ....
  10. doi The Akt isoforms are present at distinct subcellular locations
    Stacey A Santi
    Tumor Biology Group, Northeastern Ontario Regional Cancer Centre, 41 Ramsey Lake Rd, Sudbury, ON, P3E 5J1, Canada
    Am J Physiol Cell Physiol 298:C580-91. 2010
    ..b>Akt2 was colocalized with the mitochondria, while Akt3 was localized in both the nucleus and nuclear membrane...
  11. ncbi p53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells
    Michael Fraser
    Reproductive Biology Unit and Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University of Ottawa, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario KIY 4E9, Canada
    Cancer Res 63:7081-8. 2003
    ..Expression of a constitutively active Akt2 prevented CDDP-mediated down-regulation of Xiap and apoptosis in A2780s cells...
  12. pmc Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    M Delcommenne
    British Columbia Cancer Agency, Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6 Canada
    Proc Natl Acad Sci U S A 95:11211-6. 1998
    ..ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3...
  13. pmc HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
    Jennifer Van Grol
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11733. 2010
    ..The fact that pharmacologic manipulation of cell signaling restored autophagy in cells exposed to HIV-1-infected cells raises the possibility of therapeutic manipulation of cell signaling to restore autophagy in HIV-1 infection...
  14. pmc Platelet-derived growth factor protects neurons against gp120-mediated toxicity
    Fuwang Peng
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Neurovirol 14:62-72. 2008
    ..Taken together these findings lead us to suggest that PDGF-BB could be considered as a therapeutic agent that can mitigate gp120-mediated neurotoxicity in HAD...
  15. pmc Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts
    Julie A Wickenden
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Breast Cancer Res 12:202. 2010
    ....
  16. pmc AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
    J Q Cheng
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 89:9267-71. 1992
    We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to serine/threonine kinases; moreover, ..
  17. pmc Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha
    K S Walker
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland, U K
    Biochem J 331:299-308. 1998
    ..All three isoforms (PKBalpha, PKBbeta and PKBgamma) were phosphorylated at similar rates and activated to similar extents by 3-phosphoinositide-..
  18. doi Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3)
    Véronique Mouton
    Université catholique de Louvain and de Duve Institute, 75 Avenue Hippocrate, Brussels, Belgium
    Biochem J 431:267-75. 2010
    ..Together, the results indicated that SGK3 is not required for insulin-induced PFK-2 activation and that this effect is likely mediated by PKBα...
  19. pmc The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7
    Arja M Band
    Molecular Cancer Biology Program, Biomedicum Helsinki and Haartman Institute, University of Helsinki, 00014 Helsinki, Finland
    J Biol Chem 284:35441-9. 2009
    ..Therefore, Akt modulates TGF-beta signaling by temporarily adjusting the levels of two TGF-beta pathway negative regulators, Ski and Smad7. These novel findings demonstrate that Akt pathway activation directly impacts TGF-beta pathway...
  20. pmc Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells
    Cinzia Giagulli
    Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy
    PLoS ONE 6:e17831. 2011
    ..Moreover, it provides the first evidence on the presence of a p17 natural variant mimicking the p17Δ36-induced signalling in B cells and displaying the capacity of promoting B cell growth and tumorigenesis...
  21. doi Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation
    Hong Sheng Zhang
    Beijing University of Technology, District of Chaoyang, China
    Arch Biochem Biophys 505:266-72. 2011
    ....
  22. pmc Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway
    Pi Han Lin
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No 1 Chang Te Street, Taipei, Taiwan
    J Virol 85:9114-26. 2011
    ..With strong synergistic effects with current reverse transcriptase inhibitors, BPRHIV001 has the potential to become a promising lead compound for the development of a novel therapeutic agent against HIV-1 infection...
  23. pmc Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice
    Xiuying Chen
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, PR China
    Neoplasia 11:1272-84. 2009
    ....
  24. doi Plasmin triggers chemotaxis of monocyte-derived dendritic cells through an Akt2-dependent pathway and promotes a T-helper type-1 response
    Xuehua Li
    Ulm University, Institute of Pharmacology of Natural Products and Clinical Pharmacology, Helmholtzstr 20, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 30:582-90. 2010
    ..Dendritic cells (DC) accumulate in atherosclerotic arteries where they can modulate atherogenesis. We investigated whether plasmin might alter the function of human DC...
  25. pmc Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms
    Isao Hirano
    Department of Internal Medicine III, Cancer Center, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Biol Chem 284:22155-65. 2009
    ..Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells...
  26. pmc AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1)
    Seung Shick Shin
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA
    Pigment Cell Melanoma Res 23:103-11. 2010
    ..We also detected strong activation of AKT in allograft tumors specifically AKT2 as the predominant isoform involved...
  27. ncbi Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    M Jane Arboleda
    Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cancer Res 63:196-206. 2003
    To determine how AKT2 might contribute to tumor cell progression, a full-length, wild-type, human AKT2/protein kinase B (PKB)beta cDNA was transfected into a panel of eight human breast and ovarian cancer cells...
  28. pmc Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis
    Piotr G Rychahou
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77555 0536, USA
    Proc Natl Acad Sci U S A 105:20315-20. 2008
    ..for key regulators of colorectal cancer metastasis establishment, we have found that the serine/threonine kinase Akt2, a known proto-oncogene, is highly expressed in late-stage colorectal cancer and metastatic tumors...
  29. doi Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism
    Sonyo Shin
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 7:745-54. 2009
    ..Collectively, our findings indicate that AP-1 has an important function in pancreatic cancer cells and provide evidence for a previously unknown Akt-mediated mechanism of c-Jun activation...
  30. ncbi Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance
    Joseph T Brozinick
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
    Diabetes 52:935-41. 2003
    ..Additionally, these data also show that different upstream or downstream signals may regulate the activity of the various Akt isoforms...
  31. ncbi Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation
    Xshang Li
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Gastroenterology 126:122-35. 2004
    ..However, how NHE3 is regulated by the PI 3-K pathway and the role of Akt2 are poorly defined.
  32. ncbi HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected pat
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Dr MSC 1109, Building 10, Clinical Research Center, Room 1 3140, Bethesda, MD 20892 1109, USA
    Diabetes 54:23-31. 2005
    ..Vpr thus may contribute to the tissue-selective insulin resistance often observed in HIV-1-infected individuals...
  33. ncbi Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation
    A A Kapasi
    Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus for Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Am J Physiol Renal Physiol 280:F333-42. 2001
    ..These results suggest that HIV-1 gp 120 induces alterations in conflicting survival signaling pathways that contribute to the potential dual effects of gp 120 in promoting or inhibiting HMC proliferation...
  34. ncbi Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3
    S Masure
    Department of Biotechnology, Janssen Research Foundation, Beerse, Belgium
    Eur J Biochem 265:353-60. 1999
    ..These observations suggest that Akt-3 is a promising target for the discovery of novel chemotherapeutic agents which do not interfere with insulin signalling...
  35. ncbi Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line
    Pauline Chugh
    Department of Microbiology and Immunology, School of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14742, USA
    J Mol Biol 366:67-81. 2007
    ..We propose that the expression of Tat may enable HIV-1 infected microglia to survive throughout the course of infection, leading to persistent HIV-1 production and infection in the central nervous system...
  36. pmc HIV-1 Tat co-operates with IFN-gamma and TNF-alpha to increase CXCL10 in human astrocytes
    Rachel Williams
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 4:e5709. 2009
    ..Since CXCL10 levels are linked to disease severity, understanding its regulation could aid in the development of therapeutic intervention strategies for HAND...
  37. pmc Human immunodeficiency virus (HIV-1) Vpr induced downregulation of NHE1 induces alteration in intracellular pH and loss of ERM complex in target cells
    Michelle L Janket
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Virus Res 126:76-85. 2007
    ..Vpr-mediated NHE1 dyregulation is in part through GR pathway as GR antagonist, mifepristone reversed Vpr-induced NHE1 downregulation...
  38. pmc Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-alpha release in alveolar macrophages from asymptomatic HIV-positive persons in vitro
    Souvenir D Tachado
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 283:33191-8. 2008
    ....
  39. ncbi HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45
    Appakkudal R Anand
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:12289-99. 2006
    ..These results suggest a novel CD45-mediated mechanism for the HIV envelope-induced apoptosis of T cells...
  40. pmc Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:4052-61. 2009
    ..Pkc-delta(-)(/)(-)), p85alpha and p85beta subunits of the PI3K (p85alpha(-)(/)(-)beta(-)(/)(-)), or Akt1 and Akt2 (Akt1(-)(/)(-)2(-)(/)(-))...
  41. doi Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells
    Danhui Weng
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 273:257-65. 2009
    ..have been implicated in paclitaxel (PTX)-induced resistance in ovarian cancer, recent evidence has suggested that Akt2 has an important role in the protection of cells from paclitaxel-induced apoptosis...
  42. pmc MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 2:ra62. 2009
    ..We expressed each isoform individually in an Akt1(-/-)/Akt2(-/-)/Akt3(-/-) cell line...
  43. ncbi siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
    Karim Bouzakri
    Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Cell Metab 4:89-96. 2006
    ..Gene silencing revealed specialized roles of insulin signaling cascades to metabolic endpoints. IRS-1 and Akt2 were required for myoblast differentiation and glucose metabolism, whereas IRS-2 and Akt1 were dispensable...
  44. ncbi Frequent activation of AKT2 kinase in human pancreatic carcinomas
    Deborah A Altomare
    Human Genetic Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 87:470-6. 2002
    ..We previously demonstrated amplification and overexpression of the AKT2 gene in a subset of human pancreatic carcinomas...
  45. ncbi HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection
    M Kaul
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 14:296-305. 2007
    ..This finding suggests that CCR5 ligands can protect neurons at least, in part, by modulating CXCR4-mediated toxicity through heterologous desensitization...
  46. ncbi Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
    P Borgatti
    Institute of Human Anatomy, University of Ferrara, Italy
    Eur J Immunol 27:2805-11. 1997
    ..Taken together, these data suggest that the anti-apoptotic activity of low concentrations of Tat protein on Jurkat cells is mediated by a PI 3-kinase/Akt pathway...
  47. ncbi Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex
    Claudia Figueroa
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:47922-7. 2003
    We demonstrate that POSH, a scaffold for the JNK signaling pathway, binds to Akt2. A POSH mutant that is unable to bind Akt2 (POSH W489A) exhibits enhanced-binding to MLK3, and this increase in binding is accompanied by increased ..
  48. ncbi Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor
    N J Hellyer
    Department of Pharmacology, The University of Iowa, College of Medicine, Iowa City, Iowa 52242 1109, USA
    J Biol Chem 276:42153-61. 2001
    ..Recruitment of PI 3-kinase to ErbB3 was required for both activities, and it appeared that ErbB2 activation alone was not sufficient to activate PI 3-kinase signaling in these cells...
  49. ncbi Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Cancer Res 10:2846-50. 2004
    Akt is a serine/threonine kinase that plays a central role in tumorigenesis. Among the members of Akt family, Akt2 is associated with the development of human cancers...
  50. ncbi Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
    Kathleen A Martin
    Division of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 282:36112-20. 2007
    ..Notably, we find that rapamycin selectively activates only the Akt2 isoform and that Akt2, but not Akt1, is sufficient to induce contractile protein expression...
  51. ncbi Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
    Han C Dan
    Department of Pathology, Molecular Oncology, and Drug Discovery Programs, University of South Florida College of Medicine, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 277:35364-70. 2002
    ..Expression of constitutively active PI3K or active Akt, including Akt1 and Akt2, induces tuberin phosphorylation...
  52. ncbi Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes
    R Hernandez
    Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    FEBS Lett 494:225-31. 2001
    ..2) Akt phosphorylation on the regulatory residue Ser473 but not on Thr308, and (3) mobility shift in Akt1 and Akt2. However, ML-9 did not affect insulin-stimulated PI3-kinase nor PKCzeta activities...
  53. ncbi The thermotropic phase behaviour and phase structure of a homologous series of racemic beta-D-galactosyl dialkylglycerols studied by differential scanning calorimetry and X-ray diffraction
    David A Mannock
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Chem Phys Lipids 148:26-50. 2007
    ....
  54. pmc MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
    Niamh H Foley
    Department of Cancer Genetics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland
    Mol Cancer 9:83. 2010
    ..The purpose of this study was to elucidate the molecular mechanism by which miR-184 conveys pro-apoptotic effects...
  55. pmc Akt kinases in breast cancer and the results of adjuvant therapy
    Olle Stal
    Department of Biomedicine and Surgery, Division of Oncology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Breast Cancer Res 5:R37-44. 2003
    ..It mediates cell survival by acting as a transducer of signals from growth factor receptors that activate phosphatidylinositol 3-kinase...
  56. pmc Protein kinase B (AKT) mediates phospholipase D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells
    Satyananda Patel
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Biol Chem 285:32055-63. 2010
    ..associated with defective membrane translocation of NADPH oxidase components p67(phox) and p47(phox), ERK, AKT1, AKT2, but not AKT3...
  57. ncbi Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs
    Miyako Yanagihara
    Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo 192 8577, Japan
    Cancer Sci 96:620-6. 2005
    ..Three isoforms of Akt have been found: Akt1/PKBalpha, Akt2/PKBbeta and Akt3/PKBgamma...
  58. pmc Glut4 storage vesicles without Glut4: transcriptional regulation of insulin-dependent vesicular traffic
    Danielle N Gross
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    Mol Cell Biol 24:7151-62. 2004
    ..of the insulin receptor-signaling pathway (the insulin receptor, IRS-1, phosphatidylinositol 3-kinase, and Akt2) at levels comparable to those in responsive cell lines...
  59. ncbi Contraction regulation of Akt in rat skeletal muscle
    Kei Sakamoto
    Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:11910-7. 2002
    ..phosphorylation, contraction in situ significantly increased the activity of all three Akt isoforms (Akt1 > Akt2 > Akt3) with maximal activation occurring at 2.5 min and returning to base line with 15 min of contraction...
  60. pmc Determination of transmembrane topology of an inward-rectifying potassium channel from Arabidopsis thaliana based on functional expression in Escherichia coli
    N Uozumi
    BioScience Center, Nagoya University, Nagoya, 464 8601, Japan
    Proc Natl Acad Sci U S A 95:9773-8. 1998
    We report here that the inward-rectifying potassium channels KAT1 and AKT2 were functionally expressed in K+ uptake-deficient Escherichia coli. Immunological assays showed that KAT1 was translocated into the cell membrane of E. coli...
  61. doi Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model
    Eriko Taniai
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Cancer Sci 100:813-20. 2009
    ..of the promoting chemicals used, enhanced down-regulation of PTEN and up-regulation of phosphorylated (active) Akt2 and phosphorylated substrate(s) of Akt-kinase activity...
  62. pmc Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle
    Kanokwan Vichaiwong
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, U S A
    Biochem J 431:311-20. 2010
    ..one predicted Akt phosphorylation site (Thr590) in control mice, AMPKα2 inactive transgenic mice (AMPKα2i TG) and Akt2-knockout mice (Akt2 KO)...
  63. doi Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763
    Takayuki Nemoto
    Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
    Eur J Pharmacol 586:82-9. 2008
    In cultured bovine adrenal chromaffin cells, where Akt1 is the predominant isoform over Akt2 and Akt3, chronic (> or =12 h) treatment with 1-20 mM LiCl, an inhibitor of glycogen synthase kinase-3, decreased Akt1 level by approximately ..
  64. ncbi Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise
    J Turinsky
    Department of Physiology and Cell Biology, Albany Medical College, Albany, New York 12208, USA
    Am J Physiol 276:R277-82. 1999
    Activities of Akt1, Akt2, and Akt3 kinases and glucose uptake in hindlimb muscles of the rat in vivo were investigated. The rats were studied either after intravenous injection of 0...
  65. ncbi SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes
    Toshiyasu Sasaoka
    Department of Clinical Pharmacology and First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Biol Chem 279:14835-43. 2004
    ..In this regard, following insulin stimulation, a proportion of Akt2, and not Akt1, appeared to redistribute from the cytosol to the PM...
  66. pmc Regulation of gastric acid secretion by PKB/Akt2
    Anand Rotte
    Department of Physiology, University of Tubingen, D 72076 Tubingen, Germany
    Cell Physiol Biochem 25:695-704. 2010
    ..hypothesis, gastric acid secretion was determined in isolated glands from gene targeted mice lacking functional Akt2 (akt2(-/-)) or from their wild type littermates (akt2(+/+))...
  67. pmc Lipodystrophies: disorders of adipose tissue biology
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Biochim Biophys Acta 1791:507-13. 2009
    ..A/C (LMNA), peroxisome proliferator-activated receptor gamma (PPARG), v-AKT murine thymoma oncogene homolog 2 (AKT2) and zinc metalloprotease (ZMPSTE24), have been identified...
  68. doi High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast
    Megan L Troxell
    Department of Pathology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Mod Pathol 23:27-37. 2010
    ..PIK3CA and AKT1 mutations using mass spectrometry; cases that were negative were further screened for mutations in AKT2, BRAF, CDK, EGFR, ERBB2, KRAS, NRAS, and HRAS. Mutations were confirmed by sequencing or HPLC assay...
  69. pmc Strain-induced proliferation requires the phosphatidylinositol 3-kinase/AKT/glycogen synthase kinase pathway
    Christopher P Gayer
    Department of Surgery, John D Dingell Veterans Affairs Medical Center, Detroit, Michigan 48301, USA
    J Biol Chem 284:2001-11. 2009
    ..Strain MAPK activation required PI3K but not AKT. AKT isoform-specific siRNA transfection demonstrated that AKT2 but not AKT1 is required for GSK-3beta phosphorylation and the strain mitogenic effect...
  70. doi Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophy
    Masanori Iwanishi
    Diabetes and Endocrine Division, Kusatsu General Hospital 1660 Yabase, Kusatsu, Shiga 525 8585, Japan
    Metabolism 58:1681-7. 2009
    ..Sequencing of candidate genes LMNA, PPARG, AKT2, caveolin-1, as well as the PPARG4 promoter gene, which are known to be associated with familial partial ..
  71. ncbi Insertional mutagenesis and cloning of the genes required for biosynthesis of the host-specific AK-toxin in the Japanese pear pathotype of Alternaria alternata
    A Tanaka
    Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Mol Plant Microbe Interact 12:691-702. 1999
    ..One, designated AKT1, encodes a member of the class of carboxyl-activating enzymes. The other, AKT2, encodes a protein of unknown function...
  72. pmc Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice
    Roman A Timakhov
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Genes Chromosomes Cancer 48:786-94. 2009
    ..We hypothesized that constitutive activation of Akt2 could serve as a first hit for the clonal expansion of malignant T-cells by promoting cell survival and genomic ..
  73. doi Scoparia dulcis (SDF7) endowed with glucose uptake properties on L6 myotubes compared insulin
    Joo Ee Beh
    Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    J Ethnopharmacol 129:23-33. 2010
    ..e., IRS-1, PI 3-kinase, PKB/Akt2, PKC and TC 10) in L6 myotubes compared to insulin.
  74. doi Pinoresinol-4,4'-di-O-beta-D-glucoside from Valeriana officinalis root stimulates calcium mobilization and chemotactic migration of mouse embryo fibroblasts
    Kee Hun Do
    Department of Pharmacology and MRC for Ischemic Tissue Regeneration and Medical Research Institute, School of Medicine, Pusan National University, Busan 602 739, Republic of Korea
    Phytomedicine 16:530-7. 2009
    ..Cells lacking downstream mediator of PI3K such as Akt1 and Akt2 (DKO cells) showed loss of PDG-induced migration...
  75. ncbi [Insulin resistance enhanced the response of the ovary]
    Jing Wang
    Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China
    Zhonghua Yi Xue Za Zhi 89:2611-5. 2009
    To search for the role of impaired insulin signaling in the ovary reproductive failure and abnormal metabolic profiles in the AKT2- mouse.
  76. pmc Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells
    Adam S Lazorchak
    Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA
    Mol Cell 39:433-43. 2010
    ..We further show that Akt2 specifically mediates the Sin1-mTORC2 dependent suppression of il7r and rag gene expression in B cells by ..
  77. ncbi Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40
    Niketa A Patel
    Department of Biochemistry, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 280:14302-9. 2005
    ..C., and Cooper, D. C. (2001) J. Biol. Chem. 276, 22648-22654). Transient transfection of constitutively active Akt2 kinase promotes PKCbetaII exon inclusion...
  78. doi Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions
    Atsushi Fukai
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:826-36. 2010
    ..To examine the role of the phosphoinositide-dependent serine/threonine protein kinase Akt1 in chondrocytes during endochondral ossification...
  79. doi Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo
    X H Shi
    Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Cancer Gene Ther 16:227-36. 2009
    ..was to investigate whether synergistic effects can be achieved by combined silencing of two oncogenes, K-ras and Akt2, which are key players in the Ras/MAPK and PI3K/Akt signaling pathways...
  80. pmc Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity
    Mark W Musch
    Univ of Chicago, Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 295:G909-19. 2008
    ..Although aldosterone activated Akt2 and serum glucorticoid kinase-1 (SGK-1), the latter through stimulation of phosphatidylinositol 3-kinase (PI3K), ..
  81. ncbi In planta AKT2 subunits constitute a pH- and Ca2+-sensitive inward rectifying K+ channel
    Andreas Latz
    Department of Molecular Plant Physiology and Biophysics, Julius von Sachs Institute of Biosciences, University of Wuerzburg, Julius von Sachs Platz 2, 97082 Wuerzburg, Germany
    Planta 225:1179-91. 2007
    ..When expressed in Xenopus oocytes and COS cells the Arabidopsis Shaker-like K+ channel, AKT2 forms a weakly voltage-dependent channel, blocked by Ca2+ and protons...
  82. pmc Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function
    Shannon P Fortin
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Mol Cancer Res 7:1871-81. 2009
    ..TWEAK stimulation results in the phosphorylation of both Akt1 and Akt2. However, small interfering RNA (siRNA)-mediated depletion of either Akt1 or Akt2 showed that BAD serine 136 ..
  83. ncbi Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin
    D A Altomare
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Oncogene 16:2407-11. 1998
    b>Akt2 encodes a protein-serine/threonine kinase containing a pleckstrin homology domain characteristic of many signaling molecules...
  84. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
    ..5-18.5...
  85. pmc Akt2 and SGK3 are both determinants of postnatal hair follicle development
    Theodora M Mauro
    Department of Dermatology, University of California, San Francisco, San Francisco, CA 94107 2140, USA
    FASEB J 23:3193-202. 2009
    ..However, this developmental abnormality is not recapitulated in mice lacking closely related kinases Akt1, Akt2, or Akt3...
  86. ncbi Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors
    Toshifumi Sugatani
    Department of Pediatrics, Cell and Molecular Biology Unit, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:3583-9. 2005
    ..Here we show that Akt1/Akt2 play a critical role in osteoclast differentiation but not cell survival and that mammalian target of rapamycin (..
  87. ncbi Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria
    Carley R Benton
    Departments of Kinesiology and Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Biol Chem 283:4228-40. 2008
    ..proteins (COXIV and mTFA) but not with insulin-signaling proteins (phosphatidylinositol 3-kinase, IRS-1, and Akt2), nor with 5'-AMP-activated protein kinase, alpha2 subunit, and HSL...
  88. doi Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study
    Russell J Schilder
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Clin Oncol 26:3418-25. 2008
    ..The association between the expression of certain markers and clinical outcome was investigated...
  89. doi Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance
    Ton van Agthoven
    Department of Pathology, Cancer Genomics Center, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Oncol 27:542-9. 2009
    ..Here, we explored whether these BCAR genes provide predictive value for tamoxifen resistance and prognostic information for tumor aggressiveness in breast cancer patients...
  90. ncbi AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
    Sandra Koseoglu
    Department of Tumor Biology, Schering Plough Research Institute, Kenilworth, New Jersey, USA
    Cancer Biol Ther 6:755-62. 2007
    ..Conversely, in IGROV1 cells, AKT2 plays a major role in cell proliferation, but no single isoform is essential for cell survival...
  91. doi An experimental study on the antitumor effect of 131I-17-AAG in vitro and in vivo
    Tu Wenyong
    Nuclear Medicine Technology Institution, School of Clinical Medicine, Southeast University, No 87 Dingjia Qiao Road 210009 Nanjing, Jiangsu, China
    Ann Nucl Med 23:113-22. 2009
    ..To observe the antitumor effect of (131)I-17-allylamino-17-demethoxygeldanamycin ((131)I-17-AAG) in vitro/in vivo and explore its antitumor mechanism with a view to its potential therapeutic application...
  92. ncbi Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
    Ioanna G Maroulakou
    Molecular Oncology Research Institute and Department of Pathology, Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Cancer Res 67:167-77. 2007
    ..The effects of ablation of Akt1, Akt2, and Akt3 on the induction and the biology of these tumors were dramatically different, with ablation of Akt1 ..
  93. ncbi Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts
    Satoru Sumitani
    Department of Molecular Medicine, Osaka University Graduate School of Medicine C 4, Suita, Osaka 565 0871, Japan
    Endocrinology 143:820-8. 2002
    ..suppressed MCK gene transcription without affecting myogenin gene transcription, whereas heterologous expression of Akt2 increased myogenin and MCK gene transcription...
  94. ncbi Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas
    H van Dekken
    Department of Pathology, University Hospital Rotterdam, Erasmus University, The Netherlands
    Cancer Res 59:748-52. 1999
    ..1 (NRASL3), 7p12 (EGFR), 8q23-24.1 (MYC), 12q21.1, 15q25 (IGF1R), 17q12-21 (ERBB2/HER2-neu), 19q13.1 (TGFB1, BCL3, AKT2), 20p12 (PCNA), 20q12-13 (MYBL2, PTPN1), and Xq25...
  95. pmc Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    Xiao ding Peng
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 17:1352-65. 2003
    To elucidate the functions of the serine/threonine kinase Akt/PKB in vivo, we generated mice lacking both akt1 and akt2 genes. Akt1/Akt2 double-knockout (DKO) mice exhibit severe growth deficiency and die shortly after birth...
  96. pmc Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration
    Malgorzata M Ptaszynska
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Mol Cancer Res 8:309-21. 2010
    ..Furthermore, ATX knockdown decreased Akt2 mRNA levels, whereas LPA treatment strongly stimulated Akt2 expression...
  97. pmc Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: implications for the metabolic syndrome
    Paola Finocchietto
    Laboratory of Oxygen Metabolism, University Hospital, Buenos Aires, Argentina
    PLoS ONE 3:e1749. 2008
    ..We wondered whether insulin-operated signaling pathways modulate mitochondrial respiration via NO, to alternatively release complete glucose oxidation to CO(2) and H(2)O or to drive glucose storage to glycogen...
  98. pmc Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL
    Yogita Kanan
    Departments of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 113:477-88. 2010
    ..This pathway is functionally important for photoreceptor survival as deletion of IR and one of the isoforms of Akt (Akt2) resulted in stress-induced photoreceptor degeneration...
  99. doi Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells
    Aydee C Estrada
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Helmholtzstrasse 20, D 89081 Ulm, Germany
    Mol Pharmacol 77:378-87. 2010
    ..We found that the human prostate cancer cell lines LNCaP and PC-3 express predominantly Akt1 and Akt2. Selective down-regulation of Akt1, but not Akt2, by short-hairpin RNA reduced the viability of prostate cancer ..
  100. ncbi Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH
    Tove Kirkegaard
    Division of Cancer Sciences and Molecular Pathology, Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Histopathology 56:203-11. 2010
    ..There are three mammalian AKT isoforms located on chromosomes 14, 19 and 1, respectively. The aim of the study was to investigate genetic alterations of AKT in breast and prostatic cancers using fluorescence in situ hybridization (FISH)...
  101. pmc Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis
    Nhu An Pham
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    BMC Cancer 8:43. 2008
    ..This study was performed to gain a better understanding of the abnormal signaling that occurs in PDAC compared with normal duct epithelia...

Research Grants122 found, 100 shown here

  1. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2010
    ..Receptors in cardiomyocytes, (b) deletion of PDK1 expression in cardiomyocytes, (c) combined deletion of Akt1 and Akt2 in cardiomyocytes and (d) inducible expression of Akt1...
  2. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..Preliminary studies show that Elovl5 controls FoxO1 phosphorylation through the mTorc2 (rictor)-Akt2 pathway...
  3. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..is dependent on the activation of an intracellular signaling pathway that stimulates the serine/threonine kinase Akt2, leading to increased glucose uptake, glucose oxidation and glycogen synthesis...
  4. Phosphoprotein CDP138 regulates glucose metabolism
    ZHEN YUE JIANG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): It is known that activation of the PI 3-kinase - Akt2 pathway is required for insulin-stimulated glucose transporter GLUT4 translocation from intracellular storage to the plasma membrane (PM) although ..
  5. Phosphoprotein CDP138 regulates glucose metabolism
    ZHEN YUE JIANG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): It is known that activation of the PI 3-kinase - Akt2 pathway is required for insulin-stimulated glucose transporter GLUT4 translocation from intracellular storage to the plasma membrane (PM) although ..
  6. SECOND MESSENGERS IN THE RETINA
    ROBERT E contact ANDERSON; Fiscal Year: 2011
    ..Recently we have reported that deletion downstream effectors of PI3K, Akt2 and Bcl-xl, resulted in stress-induced photoreceptor degeneration...
  7. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
    ..glucose uptake in 3T3-L1 adipocytes to an extent similar to that seen upon depletion of the serine-threonine kinase Akt2. A direct interaction between WDFY2 and Akt has been observed, suggesting that WDFY2 may have a unique, conserved ..
  8. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
    ..glucose uptake in 3T3-L1 adipocytes to an extent similar to that seen upon depletion of the serine-threonine kinase Akt2. A direct interaction between WDFY2 and Akt has been observed, suggesting that WDFY2 may have a unique, conserved ..
  9. Akt-regulated pathways in platelet function
    Donna S Woulfe; Fiscal Year: 2011
    ..Specifically, our previous studies show that Akt2 plays a role in promoting fibrinogen binding and dense granule secretion and that Akt2 knockout mice are resistant ..
  10. A Novel ROS Controlling Kinase
    EILEEN ANNE FRIEDMAN; Fiscal Year: 2010
    ..the consistently amplified 660 kb subregion of the 19q13 amplicon in pancreatic cancers, while the nearby gene Akt2 was not...
  11. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian C Lewis; Fiscal Year: 2011
    ..Activating mutations in the KRAS2 oncogene, amplification of the AKT2 oncogene, and loss of the TP53, INK4A, and MADH4 tumor suppressor genes, commonly occur in this disease...
  12. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    Joseph Robert Testa; Fiscal Year: 2011
    ..Multiple thymic lymphomas from a Myr-Akt2 mouse model were found to harbor a novel inversion of chromosome 6, inv(6), with breakpoints in the T-cell receptor ..
  13. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..Activating mutations in the KRAS2 oncogene, amplification of the AKT2 oncogene, and loss of the TP53, INK4A, and MADH4 tumor suppressor genes, commonly occur in this disease...
  14. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2009
    ..Activating mutations in the KRAS2 oncogene, amplification of the AKT2 oncogene, and loss of the TP53, INK4A, and MADH4 tumor suppressor genes, commonly occur in this disease...
  15. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..Activating mutations in the KRAS2 oncogene, amplification of the AKT2 oncogene, and loss of the TP53, INK4A, and MADH4 tumor suppressor genes, commonly occur in this disease...
  16. Effect of preimplantation embryo culture on adult glucose homeostasis
    Paolo Rinaudo; Fiscal Year: 2010
    ..In addition, txnip is involved in the regulation of peripheral glucose metabolism via downregulation of AKT2/PKB2 pathway and is associated with decreased pancreatic beta cell mass...
  17. Effect of preimplantation embryo culture on adult glucose homeostasis
    Paolo Rinaudo; Fiscal Year: 2013
    ..In addition, txnip is involved in the regulation of peripheral glucose metabolism via downregulation of AKT2/PKB2 pathway and is associated with decreased pancreatic beta cell mass...
  18. THE ROLE OF THE AKT/PKB SIGNALING IN INSULIN ACTION
    MORRIS JAY BIRNBAUM; Fiscal Year: 2013
    ..The isoform specificity in hepatic metabolism is evident in liver, in that Akt2 deletion abrogates control of lipogenic gene expression, but insulin is still capable of regulating the genes ..
  19. INSULIN-LIKE GROWTH FACTORS AND MUSCLE DIFFERENTIATION
    PETER SCOTT ROTWEIN; Fiscal Year: 2011
    ..As differentiation proceeds, signal amplification occurs as more Akt2 is produced, and both Akts then participate in muscle cell maturation and in myocyte fusion to form multinucleated ..
  20. INSULIN-LIKE GROWTH FACTORS AND MUSCLE DIFFERENTIATION
    PETER SCOTT ROTWEIN; Fiscal Year: 2011
    ..As differentiation proceeds, signal amplification occurs as more Akt2 is produced, and both Akts then participate in muscle cell maturation and in myocyte fusion to form multinucleated ..
  21. The role of Akt in cell survival and cell growth
    Nissim Hay; Fiscal Year: 2013
    ..We will employ Akt1, and Akt2 KO mice as well as conditional HKII KO mice to address these issues...
  22. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    Joseph R Testa; Fiscal Year: 2013
    ..Multiple thymic lymphomas from a Myr-Akt2 mouse model were found to harbor a novel inversion of chromosome 6, inv(6), with breakpoints in the T-cell receptor ..
  23. Isoform Specific Functions for AKt1 and Akt2 in Breast Cancer Progression
    MARIA LYNN MANCINI; Fiscal Year: 2010
    ..Recent studies point to distinct functions for Akt1 and Akt2 on the invasive migration of breast cancer cell lines in vitro, where Akt1 functions as an inhibitor of invasive ..
  24. Using AKT1 and 2 and Rb1 to approach MyoD binding mechanisms genome-wide
    Sandra B Sharp; Fiscal Year: 2010
    ..3) Given their mutual influence on chromatin and MyoD acetylation, the increased expression of the Rb1 and Akt2 genes during myogenesis may be regulated by crosstalk...
  25. TGF-regulated EMT
    Philip H Howe; Fiscal Year: 2013
    ..terminating in phosphorylation of Ser43 of hnRNP E1 by isoform-specific stimulation of protein kinase B[unreadable]/Akt2, inducing its release from the BAT element and causing translational activation of Dab2 and ILEI mRNAs...
  26. SUBCELLULAR LOCALIZATION OF PI 3-KINASE SIGNALING
    Michael P Czech; Fiscal Year: 2011
    ..We shall also test whether complexes of PI(3,4,5)P3/Akt2/substrates function in docking/fusion of GLUT4-containing vesicles and regulate specific steps in these pathways in ..
  27. TGF-regulated EMT
    Philip H Howe; Fiscal Year: 2011
    ..terminating in phosphorylation of Ser43 of hnRNP E1 by isoform-specific stimulation of protein kinase B[unreadable]/Akt2, inducing its release from the BAT element and causing translational activation of Dab2 and ILEI mRNAs...
  28. The role of the Exocyst complex in insulin regulated glucose transport
    Alan R Saltiel; Fiscal Year: 2013
    ..We propose that insulin stimulates the activity of Akt2, which phosphorylates the Ral GAP RGC, resulting in sequestration from its target G protein, RalA...
  29. Design of Affinity Capture Agents for Akt1 Using in situ Click Chemistry
    Steven W Millward; Fiscal Year: 2010
    ..Bi-ligands against each of the phosphorylation states of Akt1, Akt2, and Akt3 will be generated in a similar manner...
  30. Metabolic defects in mice with adipocyte-specific deletion of Akt2
    ABIGAIL SHEARIN; Fiscal Year: 2013
    ..resistance in other key organs? To ask this question, we will use model systems with adipose- specific deletion of Akt2 and Akt1 deleted concurrently with Akt2...
  31. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2010
    ..A/C (LMNA), peroxisome proliferator-activated receptor-D (PPARG), and v-AKT murine thymoma oncogene homolog 2 (AKT2) for the autosomal dominant FPL;and LMNA and zinc metalloproteinase (ZMPSTE24) for mandibuloacral dysplasia ..
  32. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2010
    ..A/C (LMNA), peroxisome proliferator-activated receptor-D (PPARG), and v-AKT murine thymoma oncogene homolog 2 (AKT2) for the autosomal dominant FPL;and LMNA and zinc metalloproteinase (ZMPSTE24) for mandibuloacral dysplasia ..
  33. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2011
    ..A/C (LMNA), peroxisome proliferator-activated receptor-D (PPARG), and v-AKT murine thymoma oncogene homolog 2 (AKT2) for the autosomal dominant FPL;and LMNA and zinc metalloproteinase (ZMPSTE24) for mandibuloacral dysplasia ..
  34. Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    Wei Zhang; Fiscal Year: 2013
    ..Specific aim 2. To determine which of the three Akt family members (Akt1, Akt2, and Akt3) is most important for glioma development and progression. Specific aim 3...
  35. Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    WEI contact ZHANG; Fiscal Year: 2010
    ..Specific aim 2. To determine which of the three Akt family members (Akt1, Akt2, and Akt3) is most important for glioma development and progression. Specific aim 3...
  36. Role of IGF-I Receptor Signaling Pathways in Cell Survival and Migration
    HANNA IRIE; Fiscal Year: 2009
    ..Akt1 was observed to suppress IGF-I- and EGF-stimulated migration whereas Akt2 is required for migration...
  37. Role of IGF-I Receptor Signaling Pathways in Cell Survival and Migration
    Hanna Y Irie; Fiscal Year: 2010
    ..Akt1 was observed to suppress IGF-I- and EGF-stimulated migration whereas Akt2 is required for migration...
  38. Novel regulation of PI3K/Akt to direct targeted breast cancer therapies
    Wenyi Wei; Fiscal Year: 2013
    ..Furthermore, somatic mutations in Akt1 and Akt2 at E17K have been identified in breast cancer patients...
  39. Aging, Calorie Restriction, Exercise and Insulin Sensitivity
    Gregory D Cartee; Fiscal Year: 2013
    ..Greater levels of phosphorylated Akt2 (pAkt2) have been implicated as potentially pivotal for the CR-induced increase in GT...
  40. Signaling Mechanism of Platelet Glycoprotein Ib-IX
    Xiaoping Du; Fiscal Year: 2011
    ..in vivo effects of 14-3-3 inhibitor on GPIb function and thrombus formation, and delineated a novel Lyn-PI3K- Akt1/Akt2-NO-cGMP signaling pathway as an early signaling mechanism leading to integrin activation and stable platelet ..
  41. Signaling Mechanism of Platelet Glycoprotein Ib-IX
    Xiaoping Du; Fiscal Year: 2013
    ..in vivo effects of 14-3-3 inhibitor on GPIb function and thrombus formation, and delineated a novel Lyn-PI3K- Akt1/Akt2-NO-cGMP signaling pathway as an early signaling mechanism leading to integrin activation and stable platelet ..
  42. Signaling Mechanism of Platelet Glycoprotein Ib-IX
    Xiaoping Du; Fiscal Year: 2010
    ..in vivo effects of 14-3-3 inhibitor on GPIb function and thrombus formation, and delineated a novel Lyn-PI3K- Akt1/Akt2-NO-cGMP signaling pathway as an early signaling mechanism leading to integrin activation and stable platelet ..
  43. Role of IGF-I Receptor Signaling Pathways in Cell Survival and Migration
    Hanna Y Irie; Fiscal Year: 2010
    ..Akt1 was observed to suppress IGF-I- and EGF-stimulated migration whereas Akt2 is required for migration...
  44. Targeted Intervention of Breast Oncogenic Pathways
    Said M Sebti; Fiscal Year: 2013
    ..proteins whose knockdown sensitizes breast cancer cells to the knock down of the three Akt isoforms, Akt1, Akt2 or Akt3, 3) To determine if inactivation of Akt by TCN sensitizes human breast tumors to cytotoxic and anti-..
  45. Targeted Intervention of Breast Oncogenic Pathways
    Said M Sebti; Fiscal Year: 2010
    ..proteins whose knockdown sensitizes breast cancer cells to the knock down of the three Akt isoforms, Akt1, Akt2 or Akt3, 3) To determine if inactivation of Akt by TCN sensitizes human breast tumors to cytotoxic and anti-..
  46. AKT2 FUNCTION AND ONCOGENIC ACTIVITY
    JOSEPH TESTA; Fiscal Year: 2001
    ..adapted from the investigator's abstract) The applicants previously reported amplification/overexpression of the AKT2 oncogene in 10%-20% of human pancreatic and ovarian carcinomas, whereas alterations of the related gene, AKT1, are ..
  47. AKT2 FUNCTION AND ONCOGENIC ACTIVITY
    JOSEPH TESTA; Fiscal Year: 2000
    ..adapted from the investigator's abstract) The applicants previously reported amplification/overexpression of the AKT2 oncogene in 10%-20% of human pancreatic and ovarian carcinomas, whereas alterations of the related gene, AKT1, are ..
  48. AKT2 FUNCTION AND ONCOGENIC ACTIVITY
    JOSEPH TESTA; Fiscal Year: 1999
    ..adapted from the investigator's abstract) The applicants previously reported amplification/overexpression of the AKT2 oncogene in 10%-20% of human pancreatic and ovarian carcinomas, whereas alterations of the related gene, AKT1, are ..
  49. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2009
    ..The mouse has three Akt isoforms encoded by distinct genes (aktl, akt2, and akt3)...
  50. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2010
    ..The mouse has three Akt isoforms encoded by distinct genes (aktl, akt2, and akt3)...
  51. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2006
    ..The mouse has three Akt isoforms encoded by distinct genes (aktl, akt2, and akt3)...
  52. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2007
    ..The mouse has three Akt isoforms encoded by distinct genes (aktl, akt2, and akt3)...
  53. AKT2 ONCOGENE AND HUMAN ONCOGENESIS
    Jin Cheng; Fiscal Year: 2001
    AKT1 and AKT2 are human homologues of the viral oncogene v-akt.. I previously demonstrated that AKT1 is the true human counterpart of v- akt and that AKT2 encodes a novel related protein serine-threonine kinase...
  54. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY MUSLIN; Fiscal Year: 2009
    ..is dependent on the activation of an intracellular signaling pathway that stimulates the serine/threonine kinase Akt2, leading to increased glucose uptake, glucose oxidation and glycogen synthesis...
  55. AKT2 ONCOGENE AND HUMAN ONCOGENESIS
    Jin Cheng; Fiscal Year: 2000
    AKT1 and AKT2 are human homologues of the viral oncogene v-akt.. I previously demonstrated that AKT1 is the true human counterpart of v- akt and that AKT2 encodes a novel related protein serine-threonine kinase...
  56. AKT2 ONCOGENE AND HUMAN ONCOGENESIS
    Jin Cheng; Fiscal Year: 1999
    AKT1 and AKT2 are human homologues of the viral oncogene v-akt.. I previously demonstrated that AKT1 is the true human counterpart of v- akt and that AKT2 encodes a novel related protein serine-threonine kinase...
  57. Insulin Action in Muscle & Fat Cell
    John Lawrence; Fiscal Year: 2003
    ..Aim 3 is to investigate the potential interactions between betaip140 and PKBbeta, to define the mechanisms controlling betaip140 phosphorylation, and to determine the role of betaip140 in ..
  58. Structure Based Discovery of AKT Inhibitors
    Robert Glazer; Fiscal Year: 2003
    ..Expression of wild-type PTEN in human tumor cell lines or an AKT2 antisense cDNA in a human pancreatic carc/noma xenograft dramatically reduced cell and tumor growth, respectively, ..
  59. Insulin Action in Muscle & Fat Cell
    John Lawrence; Fiscal Year: 2002
    ..Aim 3 is to investigate the potential interactions between betaip140 and PKBbeta, to define the mechanisms controlling betaip140 phosphorylation, and to determine the role of betaip140 in ..
  60. Insulin Action in Muscle & Fat Cell
    John Lawrence; Fiscal Year: 2004
    ..Aim 3 is to investigate the potential interactions between betaip140 and PKBbeta, to define the mechanisms controlling betaip140 phosphorylation, and to determine the role of betaip140 in ..
  61. Insulin Action in Muscle & Fat Cell
    John Lawrence; Fiscal Year: 2005
    ..Aim 3 is to investigate the potential interactions between betaip140 and PKBbeta, to define the mechanisms controlling betaip140 phosphorylation, and to determine the role of betaip140 in ..
  62. Structure Based Discovery of AKT Inhibitors
    Robert Glazer; Fiscal Year: 2002
    ..Expression of wild-type PTEN in human tumor cell lines or an AKT2 antisense cDNA in a human pancreatic carc/noma xenograft dramatically reduced cell and tumor growth, respectively, ..
  63. Insulin Action in Muscle & Fat Cell
    John Lawrence; Fiscal Year: 2001
    ..Aim 3 is to investigate the potential interactions between betaip140 and PKBbeta, to define the mechanisms controlling betaip140 phosphorylation, and to determine the role of betaip140 in ..
  64. Evaluation of a novel AKT inhibitor in ovarian cancer
    Jiayuh Lin; Fiscal Year: 2004
    ..The AKT protein has three isoforms AKT1 (PKBalpha), AKT2 (PKBbeta) and AKT3 (PKBgamma) that have greater than 85% sequence identity and have the same structural organization...
  65. Evaluation of a novel AKT inhibitor in ovarian cancer
    Jiayuh Lin; Fiscal Year: 2005
    ..The AKT protein has three isoforms AKT1 (PKBalpha), AKT2 (PKBbeta) and AKT3 (PKBgamma) that have greater than 85% sequence identity and have the same structural organization...
  66. THE ROLE OF THE AKT/PKB SIGNALING IN INSULIN ACTION
    MORRIS JAY BIRNBAUM; Fiscal Year: 2010
    ..The isoform specificity in hepatic metabolism is evident in liver, in that Akt2 deletion abrogates control of lipogenic gene expression, but insulin is still capable of regulating the genes ..
  67. Role of IGF-I Receptor Signaling Pathways in Cell Survival and Migration
    HANNA IRIE; Fiscal Year: 2007
    ..Akt1 was observed to suppress IGF-I- and EGF-stimulated migration whereas Akt2 is required for migration...
  68. Role of IGF-I Receptor Signaling Pathways in Cell Survival and Migration
    HANNA IRIE; Fiscal Year: 2009
    ..Akt1 was observed to suppress IGF-I- and EGF-stimulated migration whereas Akt2 is required for migration...
  69. Role of IGF-I Receptor Signaling Pathways in Cell Survival and Migration
    HANNA IRIE; Fiscal Year: 2006
    ..Akt1 was observed to suppress IGF-I- and EGF-stimulated migration whereas Akt2 is required for migration...
  70. Akt-regulated pathways in platelet function
    Donna S Woulfe; Fiscal Year: 2010
    ..Specifically, our previous studies show that Akt2 plays a role in promoting fibrinogen binding and dense granule secretion and that Akt2 knockout mice are resistant ..
  71. Akt-regulated pathways in platelet function
    Donna Woulfe; Fiscal Year: 2007
    ..Specifically, our previous studies show that Akt2 plays a role in promoting fibrinogen binding and dense granule secretion and that Akt2 knockout mice are resistant ..
  72. Akt-regulated pathways in platelet function
    Donna Woulfe; Fiscal Year: 2009
    ..Specifically, our previous studies show that Akt2 plays a role in promoting fibrinogen binding and dense granule secretion and that Akt2 knockout mice are resistant ..
  73. Akt-regulated pathways in platelet function
    Donna Woulfe; Fiscal Year: 2009
    ..Specifically, our previous studies show that Akt2 plays a role in promoting fibrinogen binding and dense granule secretion and that Akt2 knockout mice are resistant ..
  74. PI 3-Kinase Isoforms and Insulin Action
    C Kahn; Fiscal Year: 2004
    ..sensitivity and longevity, and define the role of the major downstream effector Aktl in rodents and cell lines by creating and characterizing tissue specific knockout mice alone and in combination with Akt2 knockout.
  75. PI 3-Kinase Isoforms and Insulin Action
    C Kahn; Fiscal Year: 2006
    ..sensitivity and longevity, and define the role of the major downstream effector Aktl in rodents and cell lines by creating and characterizing tissue specific knockout mice alone and in combination with Akt2 knockout.
  76. PI 3-Kinase Isoforms and Insulin Action
    C Kahn; Fiscal Year: 2005
    ..sensitivity and longevity, and define the role of the major downstream effector Aktl in rodents and cell lines by creating and characterizing tissue specific knockout mice alone and in combination with Akt2 knockout.
  77. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2007
    ..A/C (LMNA), peroxisome proliferator-activated receptor-D (PPARG), and v-AKT murine thymoma oncogene homolog 2 (AKT2) for the autosomal dominant FPL; and LMNA and zinc metalloproteinase (ZMPSTE24) for mandibuloacral dysplasia ..
  78. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2009
    ..A/C (LMNA), peroxisome proliferator-activated receptor-D (PPARG), and v-AKT murine thymoma oncogene homolog 2 (AKT2) for the autosomal dominant FPL;and LMNA and zinc metalloproteinase (ZMPSTE24) for mandibuloacral dysplasia ..
  79. Using AKT1 and 2 and Rb1 to approach MyoD binding mechanisms genome-wide
    SANDRA SHARP; Fiscal Year: 2009
    ..3) Given their mutual influence on chromatin and MyoD acetylation, the increased expression of the Rb1 and Akt2 genes during myogenesis may be regulated by crosstalk...
  80. Macrophage Akt and IKKalpha signaling in apoptosis and atherosclerosis
    Macrae F Linton; Fiscal Year: 2010
    ..Two Akt isoforms are expressed in macrophages, Akt1 and Akt2, yet their relative contributions to macrophage apoptosis and atherogenesis have not been determined...
  81. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    Joseph Robert Testa; Fiscal Year: 2010
    ..Multiple thymic lymphomas from a Myr-Akt2 mouse model were found to harbor a novel inversion of chromosome 6, inv(6), with breakpoints in the T-cell receptor ..
  82. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    JOSEPH TESTA; Fiscal Year: 2009
    ..Multiple thymic lymphomas from a Myr-Akt2 mouse model were found to harbor a novel inversion of chromosome 6, inv(6), with breakpoints in the T-cell receptor ..
  83. Novel targets of rapamycin and Akt in vascular smooth muscle cell differentiation
    KATHLEEN ANN MARTIN; Fiscal Year: 2010
    ..We have found that rapamycin inhibition of the mTOR effector S6K1, and the resulting activation of Akt2 is necessary for this effect. Surprisingly, Akt1 inhibited VSMC differentiation...
  84. Novel targets of rapamycin and Akt in vascular smooth muscle cell differentiation
    Kathleen Martin; Fiscal Year: 2009
    ..We have found that rapamycin inhibition of the mTOR effector S6K1, and the resulting activation of Akt2 is necessary for this effect. Surprisingly, Akt1 inhibited VSMC differentiation...