Akt

Summary

Gene Symbol: Akt
Description: AKT serine/threonine kinase 1
Alias: AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, RAC-alpha serine/threonine-protein kinase, AKT1m, PKB alpha, RAC-PK-alpha, protein kinase B alpha, proto-oncogene c-Akt, rac protein kinase alpha, serine-threonine protein kinase, v-akt murine thymoma viral oncogene homolog 1, v-akt murine thymoma viral oncogene-like protein 1
Species: human
Products:     Akt

Top Publications

  1. Brunet A, Bonni A, Zigmond M, Lin M, Juo P, Hu L, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999;96:857-68 pubmed
    ..factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9...
  2. Brognard J, Sierecki E, Gao T, Newton A. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007;25:917-31 pubmed
    b>Akt/protein kinase B controls cell growth, proliferation, and survival...
  3. Warfel N, Niederst M, Stevens M, Brennan P, Frame M, Newton A. Mislocalization of the E3 ligase, ?-transducin repeat-containing protein 1 (?-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem. 2011;286:19777-88 pubmed publisher
    ..role in controlling the amplitude of growth factor signaling by directly dephosphorylating and thereby inactivating Akt. The cellular levels of PHLPP1 have recently been shown to be enhanced by its substrate, activated Akt, via ..
  4. Endersby R, Zhu X, Hay N, Ellison D, Baker S. Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res. 2011;71:4106-16 pubmed publisher
    The AKT family, comprising three highly homologous kinases, is an essential mediator of the PTEN/PI3K pathway, which is deregulated in many human cancers...
  5. Cicenas J. The potential role of Akt phosphorylation in human cancers. Int J Biol Markers. 2008;23:1-9 pubmed
    Akt/protein kinase B (PKB) is a serine/threonine kinase which is implicated in mediating a variety of biological responses including cell growth, proliferation and survival...
  6. Schlieman M, Fahy B, Ramsamooj R, Beckett L, Bold R. Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br J Cancer. 2003;89:2110-5 pubmed
    When activated, the serine/threonine kinase AKT mediates an antiapoptotic signal implicated in chemoresistance of various cancers...
  7. Sheikh A, Malik M, Wen G, Chauhan A, Chauhan V, Gong C, et al. BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects. J Neurosci Res. 2010;88:2641-7 pubmed publisher
    ..We also found that the expression and phosphorylation/activation of Akt kinase that regulates Bcl2 are significantly decreased in the autistic brain...
  8. Kovacina K, Park G, Bae S, Guzzetta A, Schaefer E, Birnbaum M, et al. Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem. 2003;278:10189-94 pubmed
    b>Akt (also called protein kinase B) is one of the major downstream targets of the phosphatidylinositol 3-kinase pathway...
  9. McDonald P, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, et al. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res. 2008;68:1618-24 pubmed publisher
    ..dynamics, is also a component of mammalian target of rapamycin complex 2 (mTORC2), a complex implicated in Akt phosphorylation. These functions overlap with known ILK functions...
  10. Uddin S, Siraj A, Al Rasheed M, Ahmed M, Bu R, Myers J, et al. Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers. J Clin Endocrinol Metab. 2008;93:4088-97 pubmed publisher
    ..Our objective was to investigate the role of FASN and its relationship with phosphatidylinositol 3-kinase/AKT activation in a large series of PTC in a tissue microarray format followed by studies using PTC cell lines and Nude ..

Detail Information

Publications112 found, 100 shown here

  1. Brunet A, Bonni A, Zigmond M, Lin M, Juo P, Hu L, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999;96:857-68 pubmed
    ..factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9...
  2. Brognard J, Sierecki E, Gao T, Newton A. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007;25:917-31 pubmed
    b>Akt/protein kinase B controls cell growth, proliferation, and survival...
  3. Warfel N, Niederst M, Stevens M, Brennan P, Frame M, Newton A. Mislocalization of the E3 ligase, ?-transducin repeat-containing protein 1 (?-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem. 2011;286:19777-88 pubmed publisher
    ..role in controlling the amplitude of growth factor signaling by directly dephosphorylating and thereby inactivating Akt. The cellular levels of PHLPP1 have recently been shown to be enhanced by its substrate, activated Akt, via ..
  4. Endersby R, Zhu X, Hay N, Ellison D, Baker S. Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res. 2011;71:4106-16 pubmed publisher
    The AKT family, comprising three highly homologous kinases, is an essential mediator of the PTEN/PI3K pathway, which is deregulated in many human cancers...
  5. Cicenas J. The potential role of Akt phosphorylation in human cancers. Int J Biol Markers. 2008;23:1-9 pubmed
    Akt/protein kinase B (PKB) is a serine/threonine kinase which is implicated in mediating a variety of biological responses including cell growth, proliferation and survival...
  6. Schlieman M, Fahy B, Ramsamooj R, Beckett L, Bold R. Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br J Cancer. 2003;89:2110-5 pubmed
    When activated, the serine/threonine kinase AKT mediates an antiapoptotic signal implicated in chemoresistance of various cancers...
  7. Sheikh A, Malik M, Wen G, Chauhan A, Chauhan V, Gong C, et al. BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects. J Neurosci Res. 2010;88:2641-7 pubmed publisher
    ..We also found that the expression and phosphorylation/activation of Akt kinase that regulates Bcl2 are significantly decreased in the autistic brain...
  8. Kovacina K, Park G, Bae S, Guzzetta A, Schaefer E, Birnbaum M, et al. Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem. 2003;278:10189-94 pubmed
    b>Akt (also called protein kinase B) is one of the major downstream targets of the phosphatidylinositol 3-kinase pathway...
  9. McDonald P, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, et al. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res. 2008;68:1618-24 pubmed publisher
    ..dynamics, is also a component of mammalian target of rapamycin complex 2 (mTORC2), a complex implicated in Akt phosphorylation. These functions overlap with known ILK functions...
  10. Uddin S, Siraj A, Al Rasheed M, Ahmed M, Bu R, Myers J, et al. Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers. J Clin Endocrinol Metab. 2008;93:4088-97 pubmed publisher
    ..Our objective was to investigate the role of FASN and its relationship with phosphatidylinositol 3-kinase/AKT activation in a large series of PTC in a tissue microarray format followed by studies using PTC cell lines and Nude ..
  11. Li Y, Wang Z, Kong D, Li R, Sarkar S, Sarkar F. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. J Biol Chem. 2008;283:27707-16 pubmed publisher
    We have previously shown that genistein could inhibit Akt activation and down-regulate AR (androgen receptor) and PSA (prostate-specific antigen) expression in prostate cancer (PCa) cells...
  12. Sykes S, Lane S, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, et al. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011;146:697-708 pubmed publisher
    b>AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting FOXO tumor suppressors. We show a converse role for AKT/FOXOs in acute myeloid leukemia (AML)...
  13. Scheid M, Marignani P, Woodgett J. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol. 2002;22:6247-60 pubmed
    The protein kinase B (PKB)/Akt family of serine kinases is rapidly activated following agonist-induced stimulation of phosphoinositide 3-kinase (PI3K)...
  14. Kim A, Yano H, Cho H, Meyer D, Monks B, Margolis B, et al. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. 2002;35:697-709 pubmed
    Cell survival is determined by a balance among signaling cascades, including those that recruit the Akt and JNK pathways. Here we describe a novel interaction between Akt1 and JNK interacting protein 1 (JIP1), a JNK pathway scaffold...
  15. Gort E, Groot A, Derks van de Ven T, van der Groep P, Verlaan I, van Laar T, et al. Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas. Oncogene. 2006;25:6123-7 pubmed
    ..pathophysiological relevance of HIF-1alpha regulation by the oncogenic phosphatidylinositol 3'-kinase (PI 3-kinase)/Akt signaling pathway...
  16. Cleveland Donovan K, Maile L, Tsiaras W, Tchkonia T, Kirkland J, Boney C. IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects. Endocrinology. 2010;151:3752-63 pubmed publisher
    ..IGF-I-stimulated phosphorylation of AKT on serine(473) but not threonine(308) was decreased in omental cells, and activation of downstream targets, ..
  17. Cai N, Wang Y, Zheng P. The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1. RNA. 2013;19:85-95 pubmed publisher
    ..Our findings suggest that the miR-302-367 cluster may be used as a therapeutic reagent for the treatment of cervical carcinoma. ..
  18. Tang E, Nunez G, Barr F, Guan K. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem. 1999;274:16741-6 pubmed
    ..of FKHR in the nematode Caenorhabditis elegans was identified called DAF-16, which is a downstream target of two Akt homologs in an insulin-related signaling pathway...
  19. Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, et al. PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell. 2009;136:535-50 pubmed publisher
    p53 And Akt are critical players regulating tumorigenesis with opposite effects: whereas p53 transactivates target genes to exert its function as a tumor suppressor, Akt phosphorylates its substrates and transduces downstream survival ..
  20. Li J, Zhou B. Activation of ?-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer. 2011;11:49 pubmed publisher
    ..The activation of ?-catenin and Akt pathways was examined by Western blotting and luciferase assays...
  21. De Ruiter N, Burgering B, Bos J. Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451. Mol Cell Biol. 2001;21:8225-35 pubmed
    ..Previously we have shown that protein kinase B (PKB) phosphorylates AFX causing inhibition of AFX by nuclear exclusion...
  22. Hers I. Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway. Blood. 2007;110:4243-52 pubmed
    ..of IRS-1 and IRS-2 and subsequent p85 binding is transient and precedes phosphorylation of protein kinase B (PKB) on Ser473...
  23. Zhang X, Tang N, Hadden T, Rishi A. Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta. 2011;1813:1978-86 pubmed publisher
    Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and survival...
  24. Kumar A, Purohit R. Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain. PLoS ONE. 2013;8:e64364 pubmed publisher
    AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is one of the most frequently activated proliferated and survival pathway of cancer...
  25. Tang D, Lu J, Walterscheid J, Chen H, Engler D, Sawamura T, et al. Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. J Lipid Res. 2008;49:33-47 pubmed
    ..L5 also inhibited telomerase activity to accelerate EPC senescence in correlation with reduced Akt phosphorylation...
  26. Chen J, Gomes A, Monteiro L, Wong S, Wu L, Ng T, et al. Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer. PLoS ONE. 2010;5:e12293 pubmed publisher
    The PI3K-Akt signal pathway plays a key role in tumorigenesis and the development of drug-resistance. Cytotoxic chemotherapy resistance is linked to limited therapeutic options and poor prognosis.
  27. Taga M, Hirooka E, Ouchi T. Essential roles of mTOR/Akt pathway in Aurora-A cell transformation. Int J Biol Sci. 2009;5:444-50 pubmed
    ..These tumors contain phosphorylated forms of Akt and mTOR, suggesting that Akt-mTOR pathway is involved in transformed phenotype induced by Aurora-A...
  28. Cohen Y, Shalmon B, Korach J, Barshack I, Fridman E, Rechavi G. AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma. Gynecol Oncol. 2010;116:88-91 pubmed publisher
    The PI3K/AKT pathway is frequently activated in endometrial carcinoma (EC) mainly due to mutations in the PIK3CA and PTEN genes. These events are common and believed to be the key to endometrial carcinogenesis...
  29. Hammerman P, Fox C, Birnbaum M, Thompson C. Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood. 2005;105:4477-83 pubmed
    The Akt kinases promote hematopoietic cell growth and accumulation through phosphorylation of apoptotic effectors and stimulation of mTOR-dependent translation...
  30. Hahn Windgassen A, Nogueira V, Chen C, Skeen J, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem. 2005;280:32081-9 pubmed
    The serine/threonine kinase Akt is an upstream positive regulator of the mammalian target of rapamycin (mTOR). However, the mechanism by which Akt activates mTOR is not fully understood...
  31. Misra U, Deedwania R, Pizzo S. Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. J Biol Chem. 2006;281:13694-707 pubmed
    ..We have now examined the interplay between Akt activation, regulation of apoptosis, the unfolded protein response, and activation of NF-kappaB in alpha2M*-induced ..
  32. Hinton C, Fitzgerald L, Thompson M. Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1. Exp Cell Res. 2007;313:1735-44 pubmed
    ..Here, we provide evidence that heregulin beta1-induced activation of the Akt pathway increases the nuclear content of BRCA1...
  33. Ouyang G, Liu M, Ruan K, Song G, Mao Y, Bao S. Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. Cancer Lett. 2009;281:213-9 pubmed publisher
    ..periostin, and then periostin promoted the survival of A549 cells under hypoxic microenvironment via activation of Akt/PKB pathway. Therefore, periostin and the pathway that it involved might provide a target for lung cancer treatment.
  34. Zimmermann S, Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science. 1999;286:1741-4 pubmed
    ..b>Akt (protein kinase B), a member of a different signaling pathway that also regulates these responses, interacted with ..
  35. Kim A, Sasaki T, Chao M. JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem. 2003;278:29830-6 pubmed
    ..This study also indicates that JIP1 expression can exert signaling effects independent of JNK activity. ..
  36. Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung S, et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006;127:125-37 pubmed
    ..Recent biochemical studies suggested that TORC2 is the elusive PDK2 for Akt/PKB Ser473 phosphorylation in the hydrophobic motif...
  37. Slattery M, Herrick J, Lundgreen A, Fitzpatrick F, Curtin K, Wolff R. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Carcinogenesis. 2010;31:1604-11 pubmed publisher
    ..These data suggest that genetic variation in a predefined candidate pathway for colorectal cancer contributes to both colon and rectal cancer risk. Associations appear to be strongest for CIMP+ and MSI+ tumors. ..
  38. Sancak Y, Thoreen C, Peterson T, Lindquist R, Kang S, Spooner E, et al. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell. 2007;25:903-15 pubmed
    ..Insulin stimulates Akt/PKB-mediated phosphorylation of PRAS40, which prevents its inhibition of mTORC1 in cells and in vitro...
  39. Sinnberg T, Lasithiotakis K, Niessner H, Schittek B, Flaherty K, Kulms D, et al. Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide. J Invest Dermatol. 2009;129:1500-15 pubmed publisher
    In melanoma, the PI3K-AKT-mTOR (AKT) and RAF-MEK-ERK (MAPK) signaling pathways are constitutively activated and appear to play a role in chemoresistance...
  40. Jo H, Lo P, Li Y, Loison F, Green S, Wang J, et al. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011;108:6486-91 pubmed publisher
    ..PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase...
  41. Sarbassov D, Ali S, Sengupta S, Sheen J, Hsu P, Bagley A, et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006;22:159-68 pubmed
    ..mTORC2 phosphorylates and activates Akt/PKB, a key regulator of cell survival...
  42. Yang H, Kong W, He L, Zhao J, O Donnell J, Wang J, et al. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 2008;68:425-33 pubmed publisher
    ..the 3'-untranslated region (UTR) of the PTEN, which leads to down-regulation of PTEN protein and activation of Akt pathway...
  43. Kehr E, Jorns J, Ang D, Warrick A, Neff T, Degnin M, et al. Mucinous breast carcinomas lack PIK3CA and AKT1 mutations. Hum Pathol. 2012;43:2207-12 pubmed publisher
    ..This series represents the largest study, to date, of PIK3CA genotyping in mucinous carcinoma and supports the unique pathogenetics of invasive mucinous breast carcinoma. ..
  44. Ramaswamy B, Lu Y, Teng K, Nuovo G, Li X, Shapiro C, et al. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. Cancer Res. 2012;72:5048-59 pubmed publisher
    ..Importantly, phosphoinositide 3-kinase inhibitor/protein kinase B (PI3K/AKT) pathway plays a key role in regulating Hh signaling by protecting key components of this pathway from proteasomal ..
  45. Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher
    Constitutive phosphatidylinositol 3-kinase (PI3K)-AKT activation has a causal role in adult T-cell leukaemia-lymphoma (ATLL) and other cancers...
  46. Ohtsuki T, Inada T, Arinami T. Failure to confirm association between AKT1 haplotype and schizophrenia in a Japanese case-control population. Mol Psychiatry. 2004;9:981-3 pubmed
  47. Al Salihi M, Terrece Pearman A, Doan T, Reichert E, Rosenberg D, Prescott S, et al. Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. Cancer Lett. 2009;273:225-32 pubmed publisher
    ..Tumors in the COX-2 transgenic mice had higher levels of phosphorylated epidermal growth factor receptor and Akt compared to wild-type mice...
  48. Boormans J, Hermans K, van Leenders G, Trapman J, Verhagen P. An activating mutation in AKT1 in human prostate cancer. Int J Cancer. 2008;123:2725-6 pubmed publisher
  49. Lee D, Szczepanski M, Lee Y. Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. J Cell Biochem. 2009;106:1113-22 pubmed publisher
    ..A sustained inhibition of the major survival signal, Akt, occurred in magnolol-treated cells...
  50. Mimeault M, Johansson S, Batra S. Pathobiological implications of the expression of EGFR, pAkt, NF-?B and MIC-1 in prostate cancer stem cells and their progenies. PLoS ONE. 2012;7:e31919 pubmed publisher
  51. Brownawell A, Kops G, Macara I, Burgering B. Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX. Mol Cell Biol. 2001;21:3534-46 pubmed
    ..to a subfamily of Forkhead transcription factors that are phosphorylated by protein kinase B (PKB), also known as Akt. Phosphorylation inhibits the transcriptional activity of AFX and changes the steady-state localization of the ..
  52. Jeong S, Pise Masison C, Radonovich M, Park H, Brady J. Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Oncogene. 2005;24:6719-28 pubmed
    b>AKT activation enhances resistance to apoptosis and induces cell survival signaling through multiple downstream pathways...
  53. Brunt K, Fenrich K, Kiani G, Tse M, Pang S, Ward C, et al. Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT. Arterioscler Thromb Vasc Biol. 2006;26:2027-34 pubmed
    ..Heme oxygenase-1 (HO-1) exerts cytoprotective effects in the vessel wall. Recent evidence suggests that PKB/Akt may modulate HO-1 activity...
  54. Kao G, Jiang Z, Fernandes A, Gupta A, Maity A. Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. J Biol Chem. 2007;282:21206-12 pubmed
    ..Activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway, which occurs frequently in glioblastomas due to inactivation of the tumor suppressor phosphatase and ..
  55. Kim M, Jeong E, Yoo N, Lee S. Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. Br J Cancer. 2008;98:1533-5 pubmed publisher
    Mounting evidence indicates that alterations of AKT signalling play important roles in cancer development. An earlier study discovered an oncogenic AKT1 gene mutation (AKT1 E17K) in breast, colorectal and ovarian cancers...
  56. Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs S, Dempsey P, et al. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009;136:1297-1307, e1-3 pubmed publisher
    ..EGFR phosphorylation stimulated phosphotidylinositol-3'-kinase-dependent activation of the antiapoptotic factor Akt, increased expression of the antiapoptotic factor Bcl-2, and decreased expression of the proapoptotic factor Bax...
  57. Chen X, Zhang H, Wang H, Zhu J, Zhou W, Zhang H, et al. Transforming growth factor-?1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways. Mol Biol Rep. 2012;39:3549-56 pubmed publisher
    ..In this study, we performed a study to investigate whether PI3K/Akt and MAPK/Erk1/2 signaling pathways involved in EMT in the human lung cancer A549 cells...
  58. Mitsuuchi Y, Johnson S, Sonoda G, Tanno S, Golemis E, Testa J. Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene. 1999;18:4891-8 pubmed
    ..3-p21.1, where deletions and other rearrangements have often been reported in a variety of tumor types. The identification of APPL may facilitate further analysis of the physiological and oncogenic activities of AKT2. ..
  59. Sato S, Fujita N, Tsuruo T. Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci U S A. 2000;97:10832-7 pubmed
    Serine/threonine kinase Akt/PKB is a downstream effector molecule of phosphoinositide 3-kinase and is thought to mediate many biological actions toward anti-apoptotic responses...
  60. Bajestan S, Sabouri A, Nakamura M, Takashima H, Keikhaee M, Behdani F, et al. Association of AKT1 haplotype with the risk of schizophrenia in Iranian population. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:383-6 pubmed
    b>AKT-glycogen synthase kinase 3beta (GSK3beta) signaling is a target of lithium and has been implicated in the pathogenesis of mood disorders and schizophrenia...
  61. Bleeker F, Felicioni L, Buttitta F, Lamba S, Cardone L, Rodolfo M, et al. AKT1(E17K) in human solid tumours. Oncogene. 2008;27:5648-50 pubmed publisher
    ..Second, therapeutic efforts aimed at selective targeting the AKT1(E17K) variant could be effective mainly in specific cancer types. ..
  62. Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, et al. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008;27:1932-43 pubmed publisher
    ..we demonstrate that mTOR, SIN1 and rictor, components of mammalian (m)TORC2, are required for phosphorylation of Akt and conventional protein kinase C (PKC) at the turn motif (TM) site...
  63. Abedini M, Muller E, Bergeron R, Gray D, Tsang B. Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein. Oncogene. 2010;29:11-25 pubmed publisher
    Although Akt is a determinant of cisplatin (cis-diaminedichloroplatinum (CDDP)) resistance in ovarian cancer cells, which is related in part to its inhibitory action on p53 activation, precisely how Akt confers CDDP resistance is unclear...
  64. Fraser M, Harding S, Zhao H, Coackley C, Durocher D, Bristow R. MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. Cell Cycle. 2011;10:2218-32 pubmed
    b>AKT is hyper-activated in many human cancers and promotes proliferation and cancer cell survival in response to DNA damaging agents...
  65. Fang Y, Xue J, Shen Q, Chen J, Tian L. MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma. Hepatology. 2012;55:1852-62 pubmed publisher
    ..To identify the mechanisms, we investigated the phosphoinositide 3-kinase (PI3K)/Akt pathway and found that Akt, mammalian target of rapamycin (mTOR), and p70S6K were down-regulated, whereas 4EBP1 was ..
  66. Wu Y, Mohamed H, Chillar R, Ali I, Clayton S, Slamon D, et al. Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. Breast Cancer Res. 2008;10:R3 pubmed publisher
    ..The purpose of this study is to understand the clinical significance of activated Akt (phospho-Akt or pAkt) expression in breast tumors from African-American and Latina patients with corresponding ..
  67. Plo I, Laulier C, Gauthier L, Lebrun F, Calvo F, Lopez B. AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51. Cancer Res. 2008;68:9404-12 pubmed publisher
    ..Our study reveals that the regulation of BRCA1 and RAD51 is altered in a high frequency of sporadic breast cancers and highlights the role of extracellular AKT signaling-dependent regulation of HR and genome stability.
  68. Dal Col J, Dolcetti R. GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma. Cell Cycle. 2008;7:2813-6 pubmed
    ..This effect is mediated by a constitutive activation of PI3-K/Akt, which keeps GSK-3beta inhibited...
  69. García Martínez J, Moran J, Clarke R, Gray A, Cosulich S, Chresta C, et al. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem J. 2009;421:29-42 pubmed publisher
    ..and promoting activation of AGC (protein kinase A/protein kinase G/protein kinase C) family kinases such as Akt (protein kinase B), S6K (p70 ribosomal S6 kinase) and SGK (serum and glucocorticoid protein kinase)...
  70. Pu X, Hildebrandt M, Lu C, Lin J, Stewart D, Ye Y, et al. PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy. Lung Cancer. 2011;71:82-8 pubmed publisher
    Non-small cell lung cancer (NSCLC) is still the leading cause of cancer-related deaths. The effect of the PI3K/PTEN/AKT/mTOR signaling pathway on cancer treatment, including NSCLC, has been well documented...
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    The phosphoinositide-3 kinase (PI3K)-AKT- mammalian target of rapamycin (mTOR) pathway is an important cellular pathway controlling cell growth, tumorigenesis, cell invasion and drug response...
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    ..A? affects both activation of insulin receptors and the levels of phospho-Akt, a critical signalling molecule in this pathway...
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    ..The present study was designed to investigate the prognostic significance of activated Akt in primary breast cancer and its association with other tumour biomarkers...
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    Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer, mutation of AKT1 has not been widely reported...
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    Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma. We demonstrate up-regulated Akt activity in WM, and that Akt down-regulation by Akt knockdown and the inhibitor perifosine leads to significant ..
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    ..Hypoxia-induced EMT is accompanied by increased phosphorylation, activation of Akt and the downstream signaling. Hypoxia-induced EMT was blocked by PI3K inhibitor LY294002...
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    The AKT family is implicated in cancer progression. There are three mammalian AKT isoforms located on chromosomes 14, 19 and 1, respectively...
  78. Mitra A, Raychaudhuri S, Raychaudhuri S. IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade. Cytokine. 2012;60:38-42 pubmed publisher
    ..PI3K/Akt/mTOR signaling cascade plays crucial role in cell growth and survival...
  79. Gao T, Furnari F, Newton A. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005;18:13-24 pubmed
    b>Akt/protein kinase B critically regulates the balance between cell survival and apoptosis. Phosphorylation of Akt at two key sites, the activation loop and the hydrophobic motif, activates the kinase and promotes cell survival...
  80. Zhang H, Lipovsky A, Dibble C, Sahin M, Manning B. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 2006;24:185-97 pubmed
    Feedback inhibition of the PI3K-Akt pathway by the mammalian target of rapamycin complex 1 (mTORC1) has emerged as an important signaling event in tumor syndromes, cancer, and insulin resistance...
  81. Chugh P, Fan S, Planelles V, Maggirwar S, Dewhurst S, Kim B. Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. J Mol Biol. 2007;366:67-81 pubmed
    ..that the pro-survival effects of intracellular Tat could be attributed to activation of the PI-3-kinase (PI3K)/Akt pathway in the microglial cell line...
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    ..deleted on chromosome ten (PTEN) and epidermal growth factor receptor (EGFR) pathways, serine/threonine kinase AKT, nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-3 (STAT3), play important ..
  83. Gao D, Inuzuka H, Tseng A, Chin R, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol. 2009;11:397-408 pubmed publisher
    ..show that Ser 72 is localized within a putative nuclear localization sequence and that phosphorylation of Ser 72 by Akt leads to cytoplasmic translocation of Skp2...
  84. Yang W, Wang J, Chan C, Lee S, Campos A, Lamothe B, et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 2009;325:1134-8 pubmed publisher
    b>Akt signaling plays a central role in many biological functions, such as cell proliferation and apoptosis...
  85. Xiang B, Zhang G, Liu J, Morris A, Smyth S, Gartner T, et al. A G(i) -independent mechanism mediating Akt phosphorylation in platelets. J Thromb Haemost. 2010;8:2032-41 pubmed publisher
    The serine-threonine kinase Akt plays an important role in regulating platelet activation. Stimulation of platelets with various agonists results in Akt activation as indicated by Akt phosphorylation...
  86. Gao X, Lowry P, Zhou X, DEPRY C, Wei Z, Wong G, et al. PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A. 2011;108:14509-14 pubmed publisher
    ..The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is known to be compartmentalized within plasma membrane microdomains; however, the underlying mechanisms ..
  87. Parikh C, Janakiraman V, Wu W, Foo C, Kljavin N, Chaudhuri S, et al. Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers. Proc Natl Acad Sci U S A. 2012;109:19368-73 pubmed publisher
    The protein kinase v-akt murine thymoma viral oncogene homolog (AKT), a key regulator of cell survival and proliferation, is frequently hyperactivated in human cancers...
  88. Turunen J, Peltonen J, Pietiläinen O, Hennah W, Loukola A, Paunio T, et al. The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland. Schizophr Res. 2007;91:27-36 pubmed
    ..Furthermore, results do not support a major role for NRG1, but we cannot completely exclude a minor role of this gene in the Finnish population. ..
  89. Hager M, Haufe H, Kemmerling R, Hitzl W, Mikuz G, Moser P, et al. Increased activated Akt expression in renal cell carcinomas and prognosis. J Cell Mol Med. 2009;13:2181-8 pubmed publisher
    Renal carcinogenesis is promoted by overexpression of the activated serine/ threonine kinase Akt (p-Akt) and supposedly a concomitant reduction in phosphatase and tensin homologue deleted on chromosome 10 tumour suppressor gene (PTEN), ..
  90. Santi S, Lee H. The Akt isoforms are present at distinct subcellular locations. Am J Physiol Cell Physiol. 2010;298:C580-91 pubmed publisher
    b>Akt is involved in the regulation of diverse cellular functions such as cell proliferation, energy metabolism, and apoptosis. Although three Akt isoforms are known, the function of each isoform is poorly understood...
  91. Deng R, Tang J, Ma J, Chen S, Xia L, Zhou W, et al. PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation. Oncogene. 2011;30:944-55 pubmed publisher
    ..Activation of Akt is tightly associated with resistance to radiotherapy, and Mre11 protein has important role during the repair of ..
  92. Lacey J, Yang H, Gaudet M, Dunning A, Lissowska J, Sherman M, et al. Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study. Gynecol Oncol. 2011;120:167-73 pubmed publisher
    ..39, 95% CI, 1.00-1.93). All haplotype global p-values were null. Common genetic variation in PTEN, PIK3CA, AKT1, MLH1, or MSH2 was not statistically significantly associated with endometrial cancer. ..
  93. Fu J, Chen Y, Cao J, Luo T, Qian Y, Yang W, et al. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1? pathways. Hepatology. 2011;53:181-92 pubmed publisher
    ..The p28(GANK) activates phosphoinositide 3-kinase (PI3K)-V-akt Murine Thymoma Viral Oncogene Homolog (AKT)-hypoxia-inducible factor 1? (HIF-1?) signaling to promote TWIST1, ..
  94. Beaver J, Gustin J, Yi K, Rajpurohit A, Thomas M, Gilbert S, et al. PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system. Clin Cancer Res. 2013;19:5413-22 pubmed publisher
    Activating mutations in the phosphoinositide-3-kinase (PI3K)/AKT/mTOR pathway are present in the majority of breast cancers and therefore are a major focus of drug development and clinical trials...
  95. Cardone M, Roy N, Stennicke H, Salvesen G, Franke T, Stanbridge E, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science. 1998;282:1318-21 pubmed
    Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro-caspase-9 (pro-Casp9) in cells...