Akt

Summary

Gene Symbol: Akt
Description: AKT serine/threonine kinase 1
Alias: AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, RAC-alpha serine/threonine-protein kinase, AKT1m, PKB alpha, RAC-PK-alpha, protein kinase B alpha, proto-oncogene c-Akt, rac protein kinase alpha, serine-threonine protein kinase, v-akt murine thymoma viral oncogene homolog 1, v-akt murine thymoma viral oncogene-like protein 1
Species: human

Top Publications

  1. ncbi Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    L del Peso
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 278:687-9. 1997
  2. ncbi Regulation of cell death protease caspase-9 by phosphorylation
    M H Cardone
    Program on Apoptosis and Cell Death Research, The Burnham Institute, La Jolla, CA 92037, USA
    Science 282:1318-21. 1998
  3. ncbi SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    Estela Jacinto
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 127:125-37. 2006
  4. pmc Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
    Hanna Y Irie
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 171:1023-34. 2005
  5. pmc Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
    Richard C Wang
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 338:956-9. 2012
  6. ncbi Akt enhances Mdm2-mediated ubiquitination and degradation of p53
    Yoko Ogawara
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 277:21843-50. 2002
  7. doi Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways
    Xiao Feng Chen
    Department of Thoracic Surgury, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Mol Biol Rep 39:3549-56. 2012
  8. ncbi The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    Sylvia Julien Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, 91405 Orsay Cedex, France
    Cancer Res 63:2172-8. 2003
  9. ncbi Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation
    Roble Bedolla
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Clin Cancer Res 13:3860-7. 2007
  10. ncbi Pim-1 regulates cardiomyocyte survival downstream of Akt
    John A Muraski
    San Diego State University Heart Institute, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA
    Nat Med 13:1467-75. 2007

Research Grants

  1. Molecular Regulation and Biological Functions of PIKE-A
    Keqiang Ye; Fiscal Year: 2012
  2. Saghi Ghaffari; Fiscal Year: 2015
  3. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010
  4. Goutam Ghosh Choudhury; Fiscal Year: 2016
  5. ZHEN YUE JIANG; Fiscal Year: 2016
  6. INSULIN SIGNALING DEFECTS IN PCOS
    Ricardo Azziz; Fiscal Year: 2010
  7. Erythropoietin PLUS IGF-IN NEUROPROTECTION FROM AIDS
    Stuart Lipton; Fiscal Year: 2009
  8. ZhengPing Yi; Fiscal Year: 2016
  9. Determinants of Efficacy to the Akt Inhibitor Perifosine in Colorectal Cancer
    Cathy Eng; Fiscal Year: 2012
  10. Zhenguo Liu; Fiscal Year: 2014

Patents

  1. RAC-PROTEINE KINASE AS THERAPEUTIC AGENT OR IN DIAGNOSTICS
  2. SCREENING METHOD

Detail Information

Publications556 found, 100 shown here

  1. ncbi Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    L del Peso
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 278:687-9. 1997
    ..b>Akt, a survival-promoting serine-threonine protein kinase, was activated by IL-3 in a PI 3-kinase-dependent manner...
  2. ncbi Regulation of cell death protease caspase-9 by phosphorylation
    M H Cardone
    Program on Apoptosis and Cell Death Research, The Burnham Institute, La Jolla, CA 92037, USA
    Science 282:1318-21. 1998
    Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro-caspase-9 (pro-Casp9) in cells...
  3. ncbi SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    Estela Jacinto
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 127:125-37. 2006
    ..Recent biochemical studies suggested that TORC2 is the elusive PDK2 for Akt/PKB Ser473 phosphorylation in the hydrophobic motif...
  4. pmc Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
    Hanna Y Irie
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 171:1023-34. 2005
    The Akt family of kinases are activated by growth factors and regulate pleiotropic cellular activities...
  5. pmc Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
    Richard C Wang
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 338:956-9. 2012
    Aberrant signaling through the class I phosphatidylinositol 3-kinase (PI3K)-Akt axis is frequent in human cancer. Here, we show that Beclin 1, an essential autophagy and tumor suppressor protein, is a target of the protein kinase Akt...
  6. ncbi Akt enhances Mdm2-mediated ubiquitination and degradation of p53
    Yoko Ogawara
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 277:21843-50. 2002
    ..Recent studies have reported that the phosphatidylinositol 3-OH-kinase-Akt pathway inhibits p53-mediated transcription and apoptosis, although the underlying mechanisms have yet to be ..
  7. doi Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways
    Xiao Feng Chen
    Department of Thoracic Surgury, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Mol Biol Rep 39:3549-56. 2012
    ..In this study, we performed a study to investigate whether PI3K/Akt and MAPK/Erk1/2 signaling pathways involved in EMT in the human lung cancer A549 cells...
  8. ncbi The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    Sylvia Julien Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, 91405 Orsay Cedex, France
    Cancer Res 63:2172-8. 2003
    ..Squamous cell carcinoma lines engineered to express constitutively active Akt underwent EMT, characterized by down-regulation of the epithelial markers desmoplakin, E-cadherin, and beta-catenin ..
  9. ncbi Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation
    Roble Bedolla
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Clin Cancer Res 13:3860-7. 2007
    ..we investigate whether loss of expression of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and the phosphorylated form of the cell survival protein Akt (pAkt) predicts biochemical recurrence.
  10. ncbi Pim-1 regulates cardiomyocyte survival downstream of Akt
    John A Muraski
    San Diego State University Heart Institute, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA
    Nat Med 13:1467-75. 2007
    The serine-threonine kinases Pim-1 and Akt regulate cellular proliferation and survival. Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 has been overlooked...
  11. pmc Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0647, USA
    Mol Cancer Ther 9:813-24. 2010
    ..More importantly, inhibition of AR prevented the EGF- and bFGF-induced activation of phosphoinositide 3-kinase/AKT and reactive oxygen species generation in colon cancer cells...
  12. doi Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells
    Jingshu Wang
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    J Pineal Res 53:77-90. 2012
    ..Moreover, melatonin markedly inhibited phosphorylation of PI3K, Akt, PRAS40, and GSK-3 proteins, thereby inactivating the PI3K/Akt signaling pathway...
  13. pmc Integrin β1 mediates vaccinia virus entry through activation of PI3K/Akt signaling
    Roza Izmailyan
    Academia Sinica, Taipei, Taiwan, Republic of China
    J Virol 86:6677-87. 2012
    ..Vaccinia mature virus infection triggers the activation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling, and the treatment of cells with inhibitors to block P13K activation reduces virus entry in an integrin β..
  14. ncbi Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes
    Hui Qin Wang
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0609, USA
    J Biol Chem 278:45737-45. 2003
    Both phosphatidylinositol 3-kinase (PI3K)/Akt and NF-kappaB pathways function to promote cellular survival following stress. Recent evidence indicates that the anti-apoptotic activity of these two pathways may be functionally dependent...
  15. doi Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer
    Young A Yoo
    Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea University, Seoul, Korea
    Cancer Res 71:7061-70. 2011
    ..Mechanistic investigations revealed that phosphoinositide 3-kinase (PI3K)/Akt inhibition blocked Shh-induced epithelial-mesenchyme transition, the activity of matrix metalloproteinase 9 (MMP-9),..
  16. ncbi The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt
    Sandrine Humbert
    UMR 146 CNRS Institut Curie, Centre Universitaire, 91405 Orsay Cedex, France
    Dev Cell 2:831-7. 2002
    ..in Huntington's disease, we found that insulin growth factor 1 via activation of the serine/threonine kinase Akt/PKB is able to inhibit neuronal death specifically induced by mutant huntingtin containing an expanded ..
  17. ncbi High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence
    Gustavo Ayala
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 10:6572-8. 2004
    b>Akt is a serine-threonine-kinase that phosphorylates proteins in several pathways regulating aspects of metabolism, apoptosis, and proliferation...
  18. pmc Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    Han C Dan
    Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Genes Dev 22:1490-500. 2008
    ..A key oncoprotein in a variety of cancers is the serine-threonine kinase Akt, which can be activated by mutations in PI3K, by loss of expression/activity of PTEN, or through signaling induced ..
  19. pmc Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a
    Jacqueline C Shultz
    Department of Biochemistry, Virginia Commonwealth University, VAMC, and Massey Cancer Center, Richmond, Virginia 23298, USA
    Cancer Res 70:9185-96. 2010
    ..Interrogation of oncogenic signaling pathways showed that inhibition of phosphoinositide 3-kinase or Akt dramatically increased the Casp9a/9b ratio in NSCLC cells...
  20. pmc Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000121. 2009
    ..to play a role in the maintenance of embryonic and tissue-specific stem cells, we investigated the role of the PTEN/Akt pathway in the regulation of normal and malignant mammary stem/progenitor cell populations...
  21. pmc Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2
    Devin T Worster
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 5:ra19. 2012
    ..Signaling through the PI3K (phosphatidylinositol 3-kinase)-Akt-mTOR (mammalian target of rapamycin) pathway was necessary and sufficient for the increase in p57Kip2, whereas MEK [..
  22. doi Stromal cell-derived factor-1 (SDF-1) enhances cells invasion by αvβ6 integrin-mediated signaling in ovarian cancer
    Baoyao Xue
    Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Mol Cell Biochem 380:177-84. 2013
    ..In addition, αvβ6 integrin induced the phosphorylation of p38 MAPK and PI3 K/Akt, contributing to the up-regulation of uPA, as treatment with the specific inhibitor for p38 mitogen-activated ..
  23. pmc PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling
    Wen Huang
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky, USA
    FASEB J 25:3979-88. 2011
    ..Exposure to HIV-1-infected monocytes induced phosphorylation of ERK1/2 and Akt in hCMEC by 2.5- and 3...
  24. doi PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity
    Kewei Ma
    Deparment of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada
    Cell Signal 20:684-94. 2008
    The PI3K-PKB pathway is an important and widely studied pathway in cell signaling. The enzyme activity of PI3K produces D-3 phosphoinositides, including the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2...
  25. pmc Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
    Clare G Fedele
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:22231-6. 2010
    ..INPP4B knockdown in ER-positive breast cancer cells increased Akt activation, cell proliferation, and xenograft tumor growth...
  26. ncbi The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    T F Franke
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cell 81:727-36. 1995
    The serine/threonine protein kinase encoded by the Akt proto-oncogene is catalytically inactive in serum-starved primary and immortalized fibroblasts. Here we show that Akt and the Akt-related kinase AKT2 are activated by PDGF...
  27. ncbi Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
    Juan Guinea Viniegra
    CRIB Facultad de Medicina, Universidad de Castilla La Mancha, 02071 Albacete, Spain
    J Biol Chem 280:4029-36. 2005
    ..b>PKB/Akt has also been implicated in the cellular response to insulin, gamma-radiation, and cell cycle control...
  28. ncbi High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate
    Christine C Thomas
    Division of Biological Chemistry and Molecular Microbiology, Scotland, United Kingdom
    Curr Biol 12:1256-62. 2002
    ..One of the best characterized PtdIns(3,4,5)P3/PtdIns(3,4)P2 effector proteins is protein kinase B (PKB), also known as Akt...
  29. doi Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1
    Marie Josée Demers
    Département d Anatomie et de Biologie Cellulaire, Universite de Sherbrooke, Quebec, Canada
    J Cell Biochem 107:639-54. 2009
    Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3-K/Akt-1 in intestinal epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and differentiated intestinal epithelial cells (IECs)...
  30. pmc Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat
    Yuri Kim
    Department of Pharmacy, Kyung Hee University, Seoul, South Korea
    PLoS ONE 6:e21781. 2011
    The PI3K/Akt pathway regulates various stress-related cellular responses such as cell survival, cell proliferation, metabolism and protein synthesis...
  31. pmc Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway
    Yash Mittal
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:32404-15. 2011
    GIV (Gα-interacting vesicle-associated protein, also known as Girdin) is a bona fide enhancer of PI3K-Akt signals during a diverse set of biological processes, e.g...
  32. pmc The antihypertension drug doxazosin inhibits tumor growth and angiogenesis by decreasing VEGFR-2/Akt/mTOR signaling and VEGF and HIF-1α expression
    Mi Sun Park
    Research Institute, National Cancer Center, 323, Ilsan ro, Ilsandong gu, Goyang si Gyevonggi do, Republic of Korea Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 599, Gwanank ro, Gwanakgu, Seoul, Republic of Korea
    Oncotarget 5:4935-44. 2014
    ..However, the underlying mechanisms by which it modulates PI3K/Akt intracellular signaling are poorly understood...
  33. ncbi Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
    M J Lee
    Center for Vascular Biology and Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell 8:693-704. 2001
    ..Transactivation of EDG-1 by Akt is not required for G(i)-dependent signaling but is indispensable for Rac activation, cortical actin assembly, and chemotaxis...
  34. ncbi Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion
    Rey A Carabeo
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA
    Cell Microbiol 9:2278-88. 2007
    ..Chlamydial attachment to host cells induces the activation of the Rac GTPase, which is required for the localization of WAVE2 at the sites of chlamydial entry...
  35. doi Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway
    Kyeongjin Kim
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea
    FEBS Lett 584:707-12. 2010
    ..In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-kappaB pathway...
  36. pmc p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment
    Zhaohui Feng
    Department of Radiation Oncology, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    Cold Spring Harb Perspect Biol 2:a001057. 2010
    ..These include the down-regulation of two central cell-growth pathways, the IGF/AKT-1 and mTOR pathways, and the up-regulation of the activities of the endosomal compartment...
  37. doi Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways
    Qiang Chen
    Department of Hepatobiliary Pancreas and Vessel Surgery, Chenggong Hospital of Xiamen University, Xiamen, China
    Hepatology 55:1820-9. 2012
    ..the expression of mitosis-promoting factors including Cyclin A, Cyclin B, and Cdk1 through suppressing the Akt pathway, which resulted in inhibiting CCA cell proliferation...
  38. doi Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines
    Peng Yin
    Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Cell Signal 24:1229-40. 2012
    ..that cystathionine γ-lyase (CSE) gene, catalyzed H(2)S production in trans-sulfuration pathway, was upregulated in Akt stably transformed mouse embryonic fibroblast cells, the mechanisms that elevated CSE expression by PI3K/Akt ..
  39. pmc Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells
    Yong Weon Yi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Mol Carcinog 52:667-75. 2013
    ..We report here that the PI3K/AKT pathway is constitutively active in BRCA1-defective human breast cancer cells...
  40. pmc HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2
    Francesca Caccuri
    Section of Microbiology, Department of Experimental and Applied Medicine, Medical School, University of Brescia, 25123 Brescia, Italy
    Proc Natl Acad Sci U S A 109:14580-5. 2012
    ..ERK signaling via Akt was defined as the pathway responsible for p17-induced tube formation...
  41. pmc Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes
    Ankit Shah
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, USA
    PLoS ONE 7:e52060. 2012
    ..suggest that gp120 and MA affect IL-6 but not IL-8 in a synergistic manner and this synergy was mediated by PI3K/Akt and NF-κB pathways...
  42. pmc p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage
    Maren Cam
    From the Center for Childhood Cancer and Blood Diseases, Nationwide Children s Hospital, Columbus, Ohio 43205
    J Biol Chem 289:4083-94. 2014
    ..In contrast, suppression of S6K1 and ribosomal protein S6 phosphorylation by DNA damage is Akt-dependent...
  43. ncbi Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9
    Yan Li
    Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an 710032, China
    Appl Biochem Biotechnol 135:181-92. 2006
    ..Phosphorylation of the oncogene product Akt was significantly reduced followed by decreased phosphorylation and increased processing of pro-caspase-9 on ..
  44. pmc Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins
    Olli P H Pietiläinen
    FIMM, Institute for Molecular Medicine Finland and National Public Health Institute, Biomedicum, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:683-92. 2009
    ..The established association of the same allelic variant of AKT1 with both cognitive and neuroanatomical aberrations could suggest that AKT1 exerts its effect on verbal learning and memory via neural networks involving prefrontal cortex...
  45. doi Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH
    Tove Kirkegaard
    Division of Cancer Sciences and Molecular Pathology, Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Histopathology 56:203-11. 2010
    The AKT family is implicated in cancer progression. There are three mammalian AKT isoforms located on chromosomes 14, 19 and 1, respectively...
  46. doi PI3 kinase/Akt signaling mediates epithelial-mesenchymal transition in hypoxic hepatocellular carcinoma cells
    Wei Yan
    Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China
    Biochem Biophys Res Commun 382:631-6. 2009
    ..Hypoxia-induced EMT is accompanied by increased phosphorylation, activation of Akt and the downstream signaling. Hypoxia-induced EMT was blocked by PI3K inhibitor LY294002...
  47. ncbi ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB
    Jong Kuk Park
    Laboratory of Radiation Tumor Physiology, Korea Institute of Radiological and Medical Sciences, 215 4 Gongneung dong, Nowon Gu, Seoul 139 706
    Int J Oncol 36:181-92. 2010
    ..ICAM-3 also increased Akt phosphorylation, which caused an increase in cellular migration/invasion and MMP activities...
  48. pmc Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin
    Jianghui Zhang
    Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    J Biol Chem 286:8055-66. 2011
    ..Ang1 stimulated transcriptional activity of β-catenin through phosphoinositide 3-kinase (PI3K)/AKT-mediated phosphorylation of glycogen synthase kinase 3β (GSK3β)...
  49. pmc Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation
    Pu Wang
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 285:24793-804. 2010
    ..to raise intracellular cAMP, and activate protein kinase A (PKA) and phosphatidylinositol 3-kinase (PI3-K)/Akt pathways...
  50. pmc Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains
    Xinxin Gao
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Biol Cell 19:4366-73. 2008
    As a central kinase in the phosphatidylinositol 3-kinase pathway, Akt has been the subject of extensive research; yet, spatiotemporal regulation of Akt in different membrane microdomains remains largely unknown...
  51. pmc Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells
    Hung Q Doan
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Anticancer Res 29:2473-8. 2009
    ..The phosphatidylinositol-3'-kinase (PI3K)/Akt signaling pathway is involved in CRC growth and progression...
  52. doi Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Ther 7:1772-81. 2008
    We have already reported that epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT signaling is an important pathway in regulating radiation sensitivity and DNA double-strand break (DNA-dsb) repair of human tumor cells...
  53. doi PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, Institute of Health Sciences, School of Medicine, and Biomedical Center BK21, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Atherosclerosis 213:115-21. 2010
    Phosphotase and tensin homolog deleted on chromosome 10 (PTEN) is a potent negative regulator of PI3K/Akt pathway...
  54. pmc Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression
    Mazin A Al-Salihi
    Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Rm 3365, Salt Lake City, UT 84112, USA
    Cancer Lett 273:225-32. 2009
    ..Tumors in the COX-2 transgenic mice had higher levels of phosphorylated epidermal growth factor receptor and Akt compared to wild-type mice...
  55. doi Overexpression of Par-4 sensitizes TRAIL-induced apoptosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells
    Tae Jin Lee
    Department of Immunology, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Taegu 700 712, South Korea
    J Cell Biochem 109:885-95. 2010
    ..In addition, exposure of Caki/Par-4 cells to TRAIL led to reduction of phosphorylated Akt levels, but deletion of leucine zipper domain of Par-4 did not affect these phosphorylated Akt levels...
  56. pmc Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4
    Peifeng Li
    Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 285:22713-22. 2010
    ..Here, we demonstrate that endogenous MADD is phosphorylated at three highly conserved sites by Akt, and only the phosphorylated MADD can directly interact with the TRAIL receptor DR4 thereby preventing Fas-..
  57. ncbi Direct control of the Forkhead transcription factor AFX by protein kinase B
    G J Kops
    Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, University of Utrecht, The Netherlands
    Nature 398:630-4. 1999
    ..In addition, phosphorylation of AFX by protein kinase B inhibits its transcriptional activity. Together, these results delineate a pathway for PI(3)K-dependent signalling to the nucleus...
  58. ncbi Regulation of Akt/PKB activation by tyrosine phosphorylation
    R Chen
    Department of Laboratory Medicine and Pathology and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 276:31858-62. 2001
    Activation of Akt/PKB by growth factors requires multiple phosphorylation events. Phosphorylation of Thr(308) and Ser(473) of Akt by its upstream kinase(s) or autophosphorylation is critical for optimal activation of its kinase activity...
  59. ncbi Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 118:284-9. 2006
    Akt/PKB is a serine/threonine kinase that plays an important role in survival when cells are exposed to different apoptotic stimuli...
  60. ncbi The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt
    Olorunseun O Ogunwobi
    Gastroenterology Research Unit, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Int J Colorectal Dis 22:401-9. 2007
    ..Leptin receptors are expressed in normal, premalignant and malignant colonic epithelia. We have investigated the effects of leptin on proliferation and apoptosis of colonic cancer cells and the early signalling events involved...
  61. ncbi Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells
    Tae Jin Lee
    Department of Immunology and Chronic Disease Research Center and Institute for Medical Science, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Taegu 700 712, South Korea
    J Cell Biochem 103:358-68. 2008
    ..Levels of phospho-Akt are decreased in Caki/Par-4 cells to a significantly greater extent than in Caki/Vector cells by treatment with TG, ..
  62. pmc Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis
    Jayashree Joshi
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    EMBO J 27:2181-93. 2008
    ..lack of Par-4 dramatically enhances Ras-induced lung carcinoma formation in vivo, acting as a negative regulator of Akt activation...
  63. doi ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells
    Ji Cao
    Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    Free Radic Biol Med 47:536-47. 2009
    ..Herein, we provide further evidence that the Akt signaling pathway is involved in 4-HPR-mediated apoptosis...
  64. ncbi 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
    D R Alessi
    Department of Biochemistry, University of Dundee, UK
    Curr Biol 7:776-89. 1997
    The activation of protein kinase B (PKB, also known as c-Akt) is stimulated by insulin or growth factors and results from its phosphorylation at Thr308 and Ser473...
  65. ncbi p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
    M J Rane
    Department of Medicine, University of Louisville Health Sciences Center and the Veterans Affairs Medical Center, Louisville, Kentucky 40202, USA
    J Biol Chem 276:3517-23. 2001
    b>Akt activation requires phosphorylation of Thr(308) and Ser(473) by 3-phosphoinositide-dependent kinase-1 and 2 (PDK1 and PDK2), respectively. While PDK1 has been cloned and sequenced, PDK2 has yet to be identified...
  66. ncbi Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase
    Nelly Marmy Conus
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne, VIC 8006 Australia
    J Biol Chem 277:38021-8. 2002
    Understanding the regulation of Akt has been of major interest for elucidating the control of normal cellular physiology as well as malignant transformation...
  67. pmc Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
    M G Schlieman
    Department of Surgery, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Br J Cancer 89:2110-5. 2003
    When activated, the serine/threonine kinase AKT mediates an antiapoptotic signal implicated in chemoresistance of various cancers...
  68. pmc S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt
    Hui H Zhang
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 24:185-97. 2006
    Feedback inhibition of the PI3K-Akt pathway by the mammalian target of rapamycin complex 1 (mTORC1) has emerged as an important signaling event in tumor syndromes, cancer, and insulin resistance...
  69. ncbi Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland 44106, OH, USA
    Int J Cancer 121:1424-32. 2007
    Activated phosphoinositide 3-kinase (PI3K) and its downstream target Akt/PKB are important signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis...
  70. ncbi Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1
    Daming Tang
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    J Lipid Res 49:33-47. 2008
    ..L5 also inhibited telomerase activity to accelerate EPC senescence in correlation with reduced Akt phosphorylation...
  71. doi A beta-arrestin 2 signaling complex mediates lithium action on behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Cell 132:125-36. 2008
    ..used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex ..
  72. ncbi The activation of Akt during preoperative chemotherapy for esophageal cancer correlates with poor prognosis
    Akiko Yoshioka
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Oncol Rep 19:1099-107. 2008
    The activation of the PI3K/Akt/mTOR pathway plays an important role in tumorigenesis and resistance to anticancer drugs...
  73. doi Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells
    Dae Hee Lee
    Department of Surgery and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cell Biochem 106:1113-22. 2009
    ..A sustained inhibition of the major survival signal, Akt, occurred in magnolol-treated cells...
  74. pmc beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt
    Xin Li
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536 0509, USA
    Mol Cell Biol 29:6192-205. 2009
    ..belongs to a novel family of Ser/Thr protein phosphatases that serve as tumor suppressors by negatively regulating Akt signaling...
  75. pmc Facilitating Akt clearance via manipulation of Hsp70 activity and levels
    John Koren
    Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 285:2498-505. 2010
    ..b>Akt, a major survival kinase, was found to be under the regulation of Hsp70, and when the ATPase activity of Hsp70 was ..
  76. doi Clinical significance of pAKT and CD44v6 overexpression with breast cancer
    Pei Yu
    Department of General Surgery, First People s Hospital of Shanghai Jiaotong University, Hongkou District, Room 314, Building 9, No 85 Wujing Road, Shanghai, China
    J Cancer Res Clin Oncol 136:1283-92. 2010
    CD44v6 contributes to apoptosis resistance and metastasis via upregulated activity of the PI3K/AKT pathway...
  77. pmc Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications
    Sunil Badve
    Department of Pathology and Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 176:2139-49. 2010
    Activated v-AKT murine thymoma viral oncogene homolog 1 (AKT)/protein kinase B (PKB) kinase (pAKT) is localized to the plasma membrane, cytoplasm, and/or nucleus in 50% of cancers...
  78. doi Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells
    Y Gan
    Department of Obstetrics and Gynecology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85004, USA
    Oncogene 29:4947-58. 2010
    ..of epidermal growth factor receptor (EGFR) and subsequent increases in extracellular-regulated kinase (ERK) and Akt signaling are implicated in prostate cancer progression...
  79. pmc A G(i) -independent mechanism mediating Akt phosphorylation in platelets
    B Xiang
    Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, Lexington, KY, USA
    J Thromb Haemost 8:2032-41. 2010
    The serine-threonine kinase Akt plays an important role in regulating platelet activation. Stimulation of platelets with various agonists results in Akt activation as indicated by Akt phosphorylation...
  80. doi Human immunodeficiency virus type 1 induces lytic cycle replication of Kaposi's-sarcoma-associated herpesvirus: role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-κB signaling pathways
    Xiaolei Zhu
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Mol Biol 410:1035-51. 2011
    ..cellular signaling proteins and found that HIV-1 infection of BCBL-1 cells activated phosphatidylinositol 3-kinase/AKT (also called protein kinase B, PKB) pathway and inactivated phosphatase and tensin homolog deleted on chromosome ..
  81. pmc PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains
    Xinxin Gao
    Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:14509-14. 2011
    ..The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is known to be compartmentalized within plasma membrane microdomains; however, the underlying mechanisms ..
  82. doi HT-29 human colon cancer cell proliferation is regulated by cytosolic phospholipase A(2)α dependent PGE(2)via both PKA and PKB pathways
    Liz Kisslov
    Clinical Biochemistry Department, Soroka Medical University Center, Beer Sheva, Israel
    Biochim Biophys Acta 1821:1224-34. 2012
    ..The secreted PGE(2) activated both protein kinase A (PKA) and PKB/Akt pathways via the EP2 and EP4 receptors...
  83. ncbi Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    D A Cross
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK
    Nature 378:785-9. 1995
    ..GSK3 under these conditions, and we demonstrate that it is the product of the proto-oncogene protein kinase B (PKB, also known as Akt/RAC)...
  84. ncbi Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    G Rena
    Department of Biochemistry, Medical Research Council Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 274:17179-83. 1999
    ..and Ser-319 in vitro and at a much faster rate than BAD, which is thought to be a physiological substrate for PKB. The same three sites, which all lie in the canonical PKB consensus sequences (Arg-Xaa-Arg-Xaa-Xaa-(Ser/Thr)), ..
  85. pmc The PI3K-PDK1 connection: more than just a road to PKB
    B Vanhaesebroeck
    Cell Signalling Group, Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, U K
    Biochem J 346:561-76. 2000
    ..One of the best characterized targets of PI3K lipid products is the protein kinase Akt or protein kinase B (PKB). In quiescent cells, PKB resides in the cytosol in a low-activity conformation...
  86. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
    ..Here we show that phosphatidylinositol (PI) 3-kinase and AKT activate ERalpha in the absence of estrogen...
  87. ncbi HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
    J Biol Chem 277:25195-202. 2002
    ..Kaposi's sarcoma cells from apoptosis and from down-regulation of several anti-apoptotic genes such as AKT-1, AKT-2, BCL2, BCL-XL, and insulin-like growth factor I and induced the de novo expression of the interleukin-3 ..
  88. ncbi PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
    Jiyong Liang
    Molecular and Cell Biology, Sunnybrook and Women s College Health Sciences Centre, St Mary s Hospital, McGill University, Montreal, Quebec
    Nat Med 8:1153-60. 2002
    ..Here we show that activation of protein kinase B (PKB)/Akt, contributes to resistance to antiproliferative signals and breast cancer progression in part by impairing the ..
  89. pmc Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action
    Alessandra Trencia
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del C N R, Federico II University of Naples, Naples, Italy
    Mol Cell Biol 23:4511-21. 2003
    The antiapoptotic protein PED/PEA-15 features an Akt phosphorylation motif upstream from Ser(116). In vitro, recombinant PED/PEA-15 was phosphorylated by Akt with a stoichiometry close to 1...
  90. ncbi Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Breast Cancer Res Treat 101:249-57. 2007
    Serine/threonine kinase Akt/PKB is known to regulate divergent cellular processes, including apoptosis, proliferation, differentiation, and metabolism...
  91. ncbi A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
    John D Carpten
    Division of Integrated Cancer Genomics, Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA
    Nature 448:439-44. 2007
    Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer, mutation of AKT1 has not been widely reported...
  92. ncbi Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation
    Sung Wuk Jang
    Department of Pathology, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:30836-44. 2007
    ..MstI kinase activation requires autophosphorylation and proteolytic degradation by caspases. The role of Akt in regulating MstI activity has not been previously examined...
  93. pmc The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia
    Xavier Leleu
    Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 110:4417-26. 2007
    Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma. We demonstrate up-regulated Akt activity in WM, and that Akt down-regulation by Akt knockdown and the inhibitor perifosine leads to significant ..
  94. doi Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
    Paul C McDonald
    Department of Cancer Genetics, BC Cancer Research Centre, British Columbia Cancer Agency, Vancouver, BC, Canada
    Cancer Res 68:1618-24. 2008
    ..dynamics, is also a component of mammalian target of rapamycin complex 2 (mTORC2), a complex implicated in Akt phosphorylation. These functions overlap with known ILK functions...
  95. pmc An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    Katherine Stemke-Hale
    Department of Systems Biology, The University of Texas MD Anderson Cancer, Houston, Texas 77030, USA
    Cancer Res 68:6084-91. 2008
    Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer...
  96. doi Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines
    Dongmei Guo
    Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, Shandong 250012, PR China
    Leuk Res 33:678-85. 2009
    ..through regulating the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 and the activity of Akt signaling...
  97. doi The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia
    N Gallay
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Département d Oncogenèse, Signalisation et Innovation thérapeutique, Toulouse, France
    Leukemia 23:1029-38. 2009
    The phosphoinositide 3-kinase/Akt pathway is an important signalling pathway governing cell survival and proliferation in acute myeloid leukaemia (AML)...
  98. pmc AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells
    Madhu A Lal
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington DC 20037, USA
    Cell Cycle 8:1589-602. 2009
    ..The potential for Akt to bypass G(1)/S checkpoint arrest in the face of genotoxic damage could increase genomic instability, which is a ..
  99. pmc Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase
    Zhiyong Ding
    Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e9910. 2010
    Frequent activation of the AKT serine-threonine kinase in cancer confers resistance to therapy...
  100. pmc Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L)
    L H Mayeenuddin
    Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 4265, USA
    Oncogene 29:6367-77. 2010
    ..The antibody sensitive cells had greater dependence on AKT for maintaining downstream signaling and the expression of a constitutively active AKT, which restored AKT-..
  101. doi Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer
    Jong Gwang Kim
    Department of Oncology Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea
    Oncology 79:278-82. 2010
    Signaling through the PI3K/PTEN/AKT/mTOR pathway is responsible for balancing cell survival and apoptosis...

Research Grants119 found, 100 shown here

  1. Molecular Regulation and Biological Functions of PIKE-A
    Keqiang Ye; Fiscal Year: 2012
    ..PIKE-A Abstract PIKE (PI 3-Kinase Enhancer) plays an essential role in mediating cell survival through PI 3-kinase/Akt signaling. Currently, three isoforms have been characterized: PIKE-L, -S and -A...
  2. Saghi Ghaffari; Fiscal Year: 2015
    ..The PI3-kinase-AKT pathway promotes and suppresses erythroid maturation...
  3. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010
    ..We also showed that FGF-2 reorganizes actin cytoskeleton using Rho kinases (active Rac and Cdc42, and inactive Rho), thus generating a migratory cell phenotype...
  4. Goutam Ghosh Choudhury; Fiscal Year: 2016
    ..Our results provide first evidence that in mesangial cells PDGFR-activated phosphatidylinositol (PI) 3 kinase/Akt kinase regulates proliferation and migration...
  5. ZHEN YUE JIANG; Fiscal Year: 2016
    ..We demonstrated that both the C2 domain and Akt phosphorylation site Ser197 in CDP138 are critical for insulin-induced GLUT4 translocation and membrane fusion ..
  6. INSULIN SIGNALING DEFECTS IN PCOS
    Ricardo Azziz; Fiscal Year: 2010
    ..of women with PCOS, which our data suggest may result from alterations in the phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascade, downstream of the insulin receptor (IR)...
  7. Erythropoietin PLUS IGF-IN NEUROPROTECTION FROM AIDS
    Stuart Lipton; Fiscal Year: 2009
    ..Hypothesis Tested: EPO protects neurons from HIV-related neuronal damage via a phosphoinositide (PI) 3 kinase/Akt (protein kinase B)-mediated transduction pathway acting, at least in part, through glycogen synthase kinase 3beta (..
  8. ZhengPing Yi; Fiscal Year: 2016
    ..developed in our laboratory to target proteins of interest in the PI-3 kinase pathway, such as PI-3 kinase, PDK1, AKT and AS160...
  9. Determinants of Efficacy to the Akt Inhibitor Perifosine in Colorectal Cancer
    Cathy Eng; Fiscal Year: 2012
    ..b>Akt is a serine/threonine kinase that promotes cell proliferation and survival and may be abnormally or constitutively ..
  10. Zhenguo Liu; Fiscal Year: 2014
    ..their endothelial differentiation in association with a selective and dramatic reduction of serine/threonine kinase Akt (Akt) phosphorylation...
  11. The role of PKD3 in prostate carcinogenesis
    Qiming Jane Wang; Fiscal Year: 2013
    ..an oncogenic protein in prostate cancer, and modulates crucial cell growth/survival regulatory pathways including Akt and EKR1/2 in prostate cancer cells...
  12. Improving islet transplantation outcome with Akt1
    Hongju Wu; Fiscal Year: 2013
    ..The serine/threonine protein kinase Akt/PKB is the direct downstream target of PI3 Kinase pathway, and has been found to have dual functions of anti-..
  13. Akt-regulated pathways in platelet function
    Donna S Woulfe; Fiscal Year: 2011
    The goal of this proposal is to better define the roles of Akt in platelet signaling and thrombosis. The Akt kinases are serine-threonine kinases that have well-described roles in cell survival, proliferation, and metabolism...
  14. SAMY LEWIZ HABIB; Fiscal Year: 2016
    ..Certain agonists activate PI-3 kinase and Akt, which stimulate tuberin phosphorylation resulting in its inactivation...
  15. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
    ..B. Explore the effects of LT on PI-3 kinase signaling using PH-GFP constructs, examine Rac signaling using a GFP- probe that binds active Rac, and investigate p38 MAPK signaling using specific antibodies ..
  16. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..on Ca2+ release, activation of signaling modules [phospatidylinositide (PI) 3-kinase (PI3K), protein kinase B (PKB or Akt), protein kinase A (PKA), and Src tysorine kinase (SrcK)], phosphorylation of caveolin-1 (Cav-1) and/or eNOS,..
  17. Kira Gritsman; Fiscal Year: 2014
    ..catalytic p110 subunit of PI3K, which has 3 isoforms (, , ), to activate the phosphorylation of the target kinase AKT. However, the roles of PI3K and its specific subunits in normal and leukemic stem cell function are poorly ..
  18. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..In Specific Aim 2 we will examine the role of polyamines in cell cycle regulation and PI3K/Akt cell survival activation in NB cells...
  19. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2012
    ..a downstream target of hematopoietic growth factor signaling pathways that signal through Jak/Stat and PI3 kinase/Akt dependent pathways, has been implicated in the regulation of HSC activity...
  20. RIK M DERYNCK; Fiscal Year: 2016
    ..We recently reported that, in TGF-[unreadable]-induced epithelia EMT, TGF-[unreadable] activates the PI3-kinase-Akt-TOR pathway, resulting in increased protein synthesis and cell size, and that this pathway mediates the increased ..
  21. Huizhi Wang; Fiscal Year: 2014
    ..Whereas the PI3K-Akt-GSK3-[unreadable] pathway has been demonstrated to play a critical regulatory role in TLR-mediated inflammatory ..
  22. Jian Huang; Fiscal Year: 2015
    ..a downstream target of hematopoietic growth factor signaling pathways that signal through Jak/Stat and PI3 kinase/Akt dependent pathways, has been implicated in the regulation of HSC activity...
  23. Effects of Ethanol TNF Induced Cytotoxicity
    John G Pastorino; Fiscal Year: 2012
    ..Also, derangements of the PI3-kinase/Akt pathway brought about by ethanol exposure results in phosphorylation of the voltage dependent anion carrier (VDAC), ..
  24. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
    ..2) Myofibroblast differentiation involves multiple TGFp signaling pathways including TAK1/p38/ATF2 and PI3-kinase/Akt that control myofibroblast differentiation and survival...
  25. HEPATOCELLULAR CARCINOMA AND HEPATITIS C: E2 MOLECULAR MECHANISMS
    Martina Buck; Fiscal Year: 2010
    ..Hepatocyte proliferation and liver carcinogenesis through the activation of PI3 Kinase and Akt. In pilot transaction studies and in vitro kinase assays I have obtained compelling data suggesting that E2 is a ..
  26. Lalita A Shevde; Fiscal Year: 2015
    ..Merlin protein gets degraded rapidly in the above tumor types following post-translation modifications, including Akt-mediated phosphorylation followed by ubiquitination. Merlin is understudied in breast cancer...
  27. Natarajan Muthusamy; Fiscal Year: 2016
    ..SHP1 activation leads to decreased PI3-Kinase activity and AKT phosphorylation concomitant with FOXO3A accumulation in the nucleus and induction of the pro-apoptotic gene BIM and ..
  28. Non-apoptotic functions of caspases
    STEVEN MILES FRISCH; Fiscal Year: 2012
    ..of tumor cells, as well as modulating other aspects of cytoskeletal regulation, including calpain activation, Rac activation, generation of lamellipodia, and cell adhesion...
  29. Connecting PTEN and NF2 cancer predisposition syndromes
    Maria Magdalena Georgescu; Fiscal Year: 2009
    ..3) interrelations in regulation and signaling between PTEN and NF2 in terms of phosphorylation, stability, Akt/PKB kinase and Rac GTP-ase activation...
  30. Role of TGF-b-induced Shc-Erk MAPK signaling in epithelial-mesenchymal transition
    Baby Periyanayaki Muthusamy; Fiscal Year: 2013
    ..effectors that regulate gene expression, and several non-Smad pathways such as the Erk MAP kinase and PI3 kinase-Akt-TOR pathways...
  31. Nissim Hay; Fiscal Year: 2016
    ..applicant): Our published and preliminary results, in the current funding period, support the idea that the role of Akt in energy metabolism is coupled to its role in the genesis of cancer...
  32. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
    ..A direct interaction between WDFY2 and Akt has been observed, suggesting that WDFY2 may have a unique, conserved dual role in signal transduction and membrane ..
  33. LAUREN ELIZABETH BALL; Fiscal Year: 2014
    ..Signaling through the IRS proteins to PI3K/Akt and/or the Grb2/ERK pathways is mediated and modulated by posttranslational regulation...
  34. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..Phosphorylation of AKT in MSCs from Igfbp2-/- mice was greatest when IGF-I + IGFBP-2 were added...
  35. Regulation of apoptosis by PI 3-kinase/Akt signaling
    Geoffrey M Cooper; Fiscal Year: 2012
    Summary The overall goal of the proposed research is to elucidate the mechanisms by which the PI 3-kinase/Akt/GSK-3 signaling pathway regulates cell growth and survival...
  36. Mahalia S Desruisseaux; Fiscal Year: 2015
    ..We have found a down-regulation of the PI3K/Akt insulin signaling/ survival pathway in the brains of mice with CM...
  37. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..On the other hand, PI3 kinase activates protein kinase B (PKB = Akt)...
  38. Phase I Study of IMC-A12 in Combination with Temsirolimus
    Aung Naing; Fiscal Year: 2010
    The Mammalian target of rapamycin (mTOR) is a vital effector of the PI3K/AKT/mTOR pathway involved in regulating many cellular processes that promote tumorigenesis such as cancer cell survival, proliferation, and growth...
  39. Peripheral T Cell tolerance by targeting AKT
    Claudio Anasetti; Fiscal Year: 2010
    ..Based on these preliminary data and the evidence in literature that AKT promotes T cell activation, survival, Th1 cytokine production but suppresses Treg generation, we reason that ..
  40. David Pearce; Fiscal Year: 2015
    ..D) Examine mTORC2 regulation of SGK1 relatives, Akt, SGK2, and SGK3...
  41. STEROID CONTROL OF EPITHELIAL CELL-CELL INTERACTIONS
    Gary L Firestone; Fiscal Year: 2011
    ..demonstrated that phosphorylation of GSK-3 by the serum- and glucocorticoid-inducible protein kinase (Sgk), or by Akt, at Serine-9 of GSK3-beta is required for GSK3 protein degradation...
  42. Rosalyn M Adam; Fiscal Year: 2016
    ..Data from our group have implicated the phosphoinositide-3-kinase (PI3K)/Akt pathway as a mediator of primary bladder smooth muscle cell (BSMC) growth in response to mechanical stimulation or ..
  43. Regulation of NF-kB by the Akt kinase
    Lawrence P Kane; Fiscal Year: 2010
    ..I have been studying the role of the serine/threonine kinase Akt in cellular activation and NF-?B induction...
  44. Yina Hsing Huang; Fiscal Year: 2015
    ..to the membrane lipid PIP3 suggests that it co-regulates PIP3-effectors, including the serine/threonine kinase AKT. In this grant, we propose that AKT is an important effector pathway downstream of IP4 that contributes to the ..
  45. Role of Integrin-Linked Kinase in Heart Failure and Ischemic Injury
    Anthony Rosenzweig; Fiscal Year: 2010
    ..During the first project period, we learned that while acute activation of the serine-threonine kinase, Akt, is cardioprotective, chronic activation of Akt has deleterious effects associated with feedback inhibition of ..
  46. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ..14 (Goolsby lab) leukemias demonstrates clear, robust detection of abnormal signaling in eight pathways (Kit?Erk;?Akt;?S6;?Stat5, and Flt3?Erk;?Akt;?S6;?Stat5) that demonstrate classifiable complexity...
  47. Molecular mechanisms of C/EBP alpha mediated growth arrest
    Nikolai A Timchenko; Fiscal Year: 2013
    ..and these interactions are controlled by certain signal transduction pathways such as cyclin D3-cdk4/6 and PI3K-Akt-PP2A...
  48. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
    ..studies investigating the oncogenic actions of leptin revealed that - i) leptin induces proliferation via Stat3, Akt and ERK activation, ii) leptin-induced phosphorylation of ERK and Akt was dependent on Stat3 activation, and iii) ..
  49. Paul J Grippo; Fiscal Year: 2016
    ..and apoptosis in normal tissue and during disease progression along with specific molecular events (activation of Akt, effects of PGE3-bound EP2 on Akt activation, phosphorylation of various proteins like Akt, Foxo, and Bad,) will ..
  50. Role of Fox03a in Regulating the IPF Fibroblast Phenotype
    RICHARD S NHO; Fiscal Year: 2010
    ..type I collagen suppresses normal fibroblast proliferation via high PTEN activity which inhibits the major PI3K/Akt signaling pathway...
  51. Tianyan Gao; Fiscal Year: 2016
    ..Dysregulation of Akt and protein kinase C (PKC) contributes to tumorigenesis by promoting cell proliferation and inhibiting apoptosis...
  52. Richard C Wang; Fiscal Year: 2016
    ..My mentored research project centers on a novel model for the regulation of autophagy by Akt and keratin intermediate filaments and tests this model for its effects on tumorigenesis;our model challenges the ..
  53. Prevention of PTEN deletion driven prostate cancer by selenium
    Junxuan Lu; Fiscal Year: 2012
    ..of second-generation Se, inhibits/prevents PCa progression from PIN to adenocarcinoma through targeting Akt signaling pathway in a Pten-deficiency mouse model. Two specific aims are proposed...
  54. Cancer-Associated, Interdependent Regulation of mTOR, AKT, and IKK/NF-kappaB
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Akt is widely activated in a variety of cancers via (i) mutation in the PTEN tumor suppressor, (ii) activating mutations in PI3K, and (ii) through growth factor receptor upregulation/stimulation...
  55. Pradipta Ghosh; Fiscal Year: 2016
    ..protein, and demonstration that activation of G1i3 and its interaction with GIV is essential for cell migration and Akt activation during cell migration;4) Discovery of hNOA1 (formerly called MIG78), a new dynamin-like GTPase which may ..
  56. Ronald B Gartenhaus; Fiscal Year: 2015
    ..e., NF8B inhibitor, dual PI3K/AKT inhibitor, mTOR inhibitor), will effectively repress the lymphoma phenotype pre-clinically in B-cell and T-cell NHL ..
  57. Bingcheng Wang; Fiscal Year: 2014
    Abstract: The overarching goal of this project is to evaluate the role of reciprocal regulation between EphA2 and Akt in glioma invasion and to understand the underlying molecular mechanisms...
  58. Bingcheng Wang; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): There are two major goals in this proposal. One is to elucidate if Akt-EphA2 signaling axis is a "driver" mechanism underlying malignant progression of human prostate cancer (PCa);the other is to ..
  59. PI3K/Akt-mediated PDGFRalpha signaling in craniofacial development
    KATHERINE ANN FANTAUZZO; Fiscal Year: 2013
    ..Because PI3K/Akt signaling impacts signaling pathways that have such disparate functions in proliferation, cell growth or metabolism,..
  60. Weei Chin Lin; Fiscal Year: 2016
    ..Recently we uncovered a novel pocket proteins-independent pathway involving PI3K/Akt and a BRCT domain-containing protein TopBP1 in the control of E2F1 Our preliminary data further demonstrate E2F can ..
  61. Hui Kuan Lin; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Akt/PKB signaling plays a central role in many biological functions, such as cell proliferation, apoptosis, cell metabolism, and protein translation...
  62. Dario Marchetti; Fiscal Year: 2015
    ..Third, we discovered that HPSE regulates Rac and Rho, critical mediators of cytoskeletal dynamics which is a fundamental process in the interplay between tumor ..
  63. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  64. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  65. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Despite having impaired mitochondrial oxidation, TKO mice showed increased insulin/Akt signaling due to decreased amount of active PTEN (reduced form) and were resistance to high fat diet-induced ..
  66. Shi Yuan Cheng; Fiscal Year: 2016
    ..EGFRvIII and EGF induce tyrosine phosphorylation (p-Y) of Y621 and Y750 of ESDN that activate TRAF6-Akt- and CrkII-Rac1- signaling and promote glioblastoma cell survival and invasion...
  67. Jennifer D Black; Fiscal Year: 2016
    ..permitting its binding to a protein called EBP50 which is critical for the recruitment of ERM proteins that enable AKT signaling at the membrane. Ezrin T567 and EBP50 offer potential for novel anti-metastatic targets...
  68. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..osteoclastogenesis by two distinct mechanisms: 1) ATF4 modulates M-CSF induction of RANK expression via PI3K/AKT-dependent phosphorylation and protein stabilization and/or activation;2) ATF4 mediates RANKL induction of NFATc1 ..
  69. Estela Jacinto; Fiscal Year: 2016
    ..This novel function of mTORC2 involves phosphorylation of Akt/PKB and is critical only under stress conditions. We have identified SIN1 as an integral component of mTORC2...
  70. The role of phosphorylation of Ulk1 by GSK-3b in myocardial autophagy and aging
    Peiyong Zhai; Fiscal Year: 2013
    ..is active under resting conditions and inhibited via phosphorylation at Serine9 (S9) by upstream protein kinase B/Akt. It has been shown that S9 phosphorylation of GSK-3b is highly elevated in the heart of old animals and in stress-..
  71. JOY N JONES BUIE; Fiscal Year: 2014
    ..with the eNOS promoter region and by 2) causing increased protein phosphatase 2A activation and/or decreased Akt (protein kinase B) expression...
  72. RONALD ROBERT SEESE; Fiscal Year: 2015
    ..Specifically, these mutants exhibit defects in signaling through Rac GTPase, stabilization of activity-driven changes in spine filamentous (F) actin, and consolidation of LTP...
  73. Carla J Shatz; Fiscal Year: 2016
    ..Changes in expression and phosphorylation levels will be assessed in candidate pathways including MAP Kinase, AKT and mTOR signaling...
  74. I Ping Chen; Fiscal Year: 2014
    ..Two critical regulatory mechanisms in actin biology, the activation of GTPase family members Rac, Rho and Cdc42, and tyrosine phosphorylation in iPS-derived OCs of controls and CMD patients will be examined by ..
  75. Ha Linh Vu; Fiscal Year: 2016
    ..cancer cells, TBK1 mediates oncogenesis through its phosphorylation and activation of the pro-survival kinase AKT. We show that NRAS expression increases TBK1 activation in melanoma cells...
  76. Srikanta Dash; Fiscal Year: 2016
    ..iv). We showed that HCV infection does not alter IFN-? receptor-1 expression. IFN-? activates Stat3, AKT and MAPK pathways to inhibit HCV replication and overcomes IFN-[unreadable] /ribavirin resistance mechanisms ..
  77. Victoria Arango; Fiscal Year: 2016
    ..of TPH2 and that suicides will have higher GSK3beta expression associated with the lower TPH2 function and higher AKT and p-AKT to inactivate GSK3beta...
  78. CATHERINE GLEASON; Fiscal Year: 2016
    ..SGK1 and Akt are highly related protein kinases that function as key mediators of the signaling pathways that control ion and ..
  79. Richard F Loeser; Fiscal Year: 2016
    ..Our studies will focus on mechanisms by which excessive levels of ROS disrupt the IRS-1-PI-3 kinase-Akt signaling pathway...
  80. Nitric Oxide and the Cellular Pathogenesis of Portal Hypertension
    Don C Rockey; Fiscal Year: 2012
    ..defects in eNOS after liver injury, including reduced phosphorylation of eNOS by the protein kinase, Akt. New data indicate that GRK2 interacts with and affects Akt activity...
  81. Novel SET Antagonists for the Treatment of Chronic Myelogenous Leukemia
    Dale J Christensen; Fiscal Year: 2013
    ..CML cells and blast phase CML cells;evaluate the activatin of PP2A in these cells;determine the effect of OP449 treatment on phosphorylation of BCR/ABL, ERK, AKT and STAT5;an inhibit growth in an in vivo model of CML.
  82. Wafik S El-Deiry; Fiscal Year: 2016
    ..Furthermore, we found that TIC10 results in the dual inactivation of Akt and ERK, thereby inhibiting their constitutive phosphorylation of Fox3a and potentiating its translocation to the ..
  83. Estela Jacinto; Fiscal Year: 2016
    ..This complex plays a pivotal role in the phosphorylation and activation of Akt, a protein kinase that is often deregulated in cancer...
  84. Satya P Kunapuli; Fiscal Year: 2016
    ..In this application, we propose to test the overall hypothesis that PDK1-Akt-Pyk2 axis regulates platelet functional responses...
  85. Lorraine C Santy; Fiscal Year: 2016
    ..for building a pro-migratory circuit that links activatin of Arf6 by cytohesin-2 to the downstream activation of Rac by Dock180...
  86. Mechanism of tumor metastases suppression by Drg1
    Kounosuke Watabe; Fiscal Year: 2012
    ..are four folds: (i) interacts with Wnt receptor, LRP6, (ii) activates Wnt suppressor, GSK3(3, (iii) suppresses Akt activity, (iv) down-modulates the expression of the metastases promoter, ATF3, and (v) up-regulates the expression ..
  87. Ki-Ras Signaling in Pancreatic Cancer: Role of a Novel Akt Regulator
    Sushovan Guha; Fiscal Year: 2013
    ..the role and regulation of the phosphoinositide 3-kinase (PI3K) signaling pathway and its protein ki- nase mediator Akt in PDAC and develop more effective antagonists against them for cancer prevention and therapy than are currently ..
  88. James Salzer; Fiscal Year: 2016
    ..Specifically, we will: i) investigate whether Akt is a primary effector of PI 3-kinase- dependent survival and ensheathment by analyzing mice deficient in Akt ..
  89. The kinase toolbox: Mapping the spatial and temporal regulation of cell signaling
    Sivaraj Sivaramakrishnan; Fiscal Year: 2013
    ..insights to understand the similarities and differences in the regulation of five closely related AGC kinases (PKA, Akt/PKB, PKC, PDK1 and S6K1)...
  90. Terrence A Barrett; Fiscal Year: 2015
    ..Studies performed during the prior award period demonstrated that Akt phosphorylation of B-catenin increases in ISCs during colitis and colitis-induced cancer...
  91. John J Ryan; Fiscal Year: 2016
    ..We demonstrate that IL-10 suppresses Fc?RI-mediated activation by targeting Fyn, Stat5, and Akt for degradation...
  92. KOY Y SAETEURN; Fiscal Year: 2015
    ..TGF-b also activates non-Smad pathways including the PI3K-Akt-mTOR and Erk- MAP kinase pathways, key signaling pathways that are induced by receptor tyrosine kinases and are ..
  93. Qing Miao; Fiscal Year: 2015
    ..Results, we present new data showing that NgBR binds farnesylated Ras (F-Ras) and in so doing, activate Ras-PI3K-Akt dependent pathways to induce EC migration...
  94. Cheryl L Walker; Fiscal Year: 2016
    ..We do not know: 1) Which kinases/pre-genomic signaling pathways beyond PI3K/AKT are activated by "obesogens" in the liver (or other tissues);2) Which epigenomic programmers are targeted by these ..
  95. Hui Kuan Lin; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): As loss of PTEN tumor suppressive function resulting in aberrant Akt activation is a prevalent event in human cancers and associated with cancer metastasis, it is important to identify the key ..
  96. Oncogenic role of PIK3CA hotspot mutations
    RAMON E PARSONS; Fiscal Year: 2013
    ..Although both of these mutations increase the kinase enzymatic activity, upregulate the downstream AKT pathway, and promote cell transformation upon overexpression, in human tumors they do not act alone and are ..
  97. ASISH KUMAR GHOSH; Fiscal Year: 2016
    ..In addition, we have shown that CLL MV and CLL stromal cell interaction results in robust activation of the AKT signaling pathway in CLL-bone marrow stromal cells (BMSC), leading to enhanced production of vascular endothelial ..
  98. Nuclear GTPase PIKE Regulation and Functions
    Keqiang Ye; Fiscal Year: 2013
    ..Moreover, we found that Akt feeds back and phosphorylates PIKE-L. However, the biological significance of this event remains elusive...

Patents2

  1. RAC-PROTEINE KINASE AS THERAPEUTIC AGENT OR IN DIAGNOSTICS
    Patent Number: WO9718303-A1; Date:1997-05-22
  2. SCREENING METHOD
    Patent Number: WO9722717-A1; Date:1997-06-26