AKR1C4

Summary

Gene Symbol: AKR1C4
Description: aldo-keto reductase family 1 member C4
Alias: 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, aldo-keto reductase family 1 member C4, 3-alpha-HSD1, chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4, dihydrodiol dehydrogenase isozyme DD4, type I 3-alpha-hydroxysteroid dehydrogenase
Species: human
Products:     AKR1C4

Top Publications

  1. Kume T, Iwasa H, Shiraishi H, Yokoi T, Nagashima K, Otsuka M, et al. Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver. Pharmacogenetics. 1999;9:763-71 pubmed
    ..The results substantiate the existence of polymorphic forms for human liver DD, and also suggest the importance of the residue at position 311 for substrate binding to the enzyme. ..
  2. Jemaà M, Fezai M, Bissinger R, Lang F. Methods Employed in Cytofluorometric Assessment of Eryptosis, the Suicidal Erythrocyte Death. Cell Physiol Biochem. 2017;43:431-444 pubmed publisher
    ..GSH) with mercury orange 1(4-chloromercuryphenyl-azo-2-naphthol), lipid peroxidation with BODIPY 581/591 C11 fluorescence, and ceramide abundance with specific antibodies...
  3. de Andrade A, Arruda R, Torres M, Pieri N, Leite T, Celeghini E, et al. Nitric oxide in frozen-thawed equine sperm: Effects on motility, membrane integrity and sperm capacitation. Anim Reprod Sci. 2018;: pubmed publisher
    ..of tyrosine residues phosphorylation in the membrane (F0426), nitric oxide (DAF-2/DA), lipid peroxidation (C11-BODIPY581/591)] by flow cytometry...
  4. Harris R, Williams T, Waring R, Hodges N. Molecular basis of carcinogenicity of tungsten alloy particles. Toxicol Appl Pharmacol. 2015;283:223-33 pubmed publisher
    ..exposed to WNC 91-6-3 particles and responses were compared with those from a rat skeletal muscle cell line (L6-C11). Toxicity was assessed by the adenylate kinase assay and microscopy, DNA damage by the Comet assay...
  5. Norelli S. Could DNA-reactive B lymphocytes be activated through HIV-1 DNA-stimulation involving BCR/TLR-9 pathway to yield antibodies targeting viral DNA?. Med Hypotheses. 2014;83:659-63 pubmed publisher
    ..deacetylated, co-treatment with a small molecule inhibitor of DNA methylation, such as 5-aza-2'-deoxycytidine (aza-Cdr), and histone deacetylase inhibitors (HDACi), they would favor higher accessibility by antibodies to viral DNA, ..
  6. Ren J, Chu Y, Ma H, Zhang Y, Zhang X, Zhao D, et al. Epigenetic interventions increase the radiation sensitivity of cancer cells. Curr Pharm Des. 2014;20:1857-65 pubmed
    ..The genes expression of the p53, RASSF1, and DAPK gene families was increased by 5-aza-CdR, which induces G2-M phase arrest and increased apoptosis...
  7. Petersen T, Laslett M, Juhl C. Clinical classification in low back pain: best-evidence diagnostic rules based on systematic reviews. BMC Musculoskelet Disord. 2017;18:188 pubmed publisher
    ..The purpose of this study was to develop best evidence Clinical Diagnostic Rules (CDR] for the identification of the most common patho-anatomical disorders in the lumbar spine; i.e...
  8. Cerny K, Garbacik S, Skees C, Burris W, Matthews J, Bridges P. Gestational form of Selenium in Free-Choice Mineral Mixes Affects Transcriptome Profiles of the Neonatal Calf Testis, Including those of Steroidogenic and Spermatogenic Pathways. Biol Trace Elem Res. 2016;169:56-68 pubmed publisher
    ..05) by form of Se consumed by dams of developing bull calves, while AKR1C4 (aldo-keto reductase family 1, member C4) and CCND2 (cyclin D2) tended (P < 0.09) to be affected...
  9. Nakagawa H, Toyoda Y, Albrecht T, Tsukamoto M, Praetorius M, Ishikawa T, et al. Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma?. Med Hypotheses. 2018;114:19-22 pubmed publisher
    ..that the trend associated with the 538G allele frequency of the adenosine triphosphate-binding cassette transporter C11 (ABCC11) gene, the determinant of wet-type earwax, and ethnic groups was similar to that between the incidence of ..

More Information

Publications143 found, 100 shown here

  1. Xu Z, Yang S, Zhao S, Zheng C, Li H, Zhang Y, et al. Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case-Control Study. EBioMedicine. 2016;5:105-13 pubmed publisher
    ..The cognitive ability was evaluated using Minimum Mental State Examination (MMSE) and Clinical Dementia Rating (CDR), and the mild cognitive impairment (MCI) was diagnosed by Petersen's criteria...
  2. Shi L, Ito F, Wang Y, Okazaki Y, Tanaka H, Mizuno M, et al. Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy. Free Radic Biol Med. 2017;108:904-917 pubmed publisher
    ..Three oxidative stress probes (CM-H2DCFDA, MitoSOX and C11-BODIPY) demonstrated reactive oxygen species (ROS) generation by NTP, which was inhibited by DFO...
  3. Wischnewski F, Pantel K, Schwarzenbach H. Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. Mol Cancer Res. 2006;4:339-49 pubmed
    ..In the current study, we have examined the influence of the DNA methylase inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR) together with the histone deacetylase inhibitor trichostatin A on the expression of MAGE-A1, -A2, -A3, and -A12 ..
  4. Liu L, Deng W, Zhou X, Chen R, Xiang M, Guo Y, et al. The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells. Int J Oncol. 2016;48:421-9 pubmed publisher
    ..In this study, HepG2 cells were treated with adenosine or 5-Aza‑cdR. Methylation status of MEG3 promoter was detected by methylation specific PCR (MSP) and MEG3 expression was ..
  5. Strigel R, Rollenhagen J, Burnside E, Elezaby M, Fowler A, Kelcz F, et al. Screening Breast MRI Outcomes in Routine Clinical Practice: Comparison to BI-RADS Benchmarks. Acad Radiol. 2017;24:411-417 pubmed publisher
    ..We calculated abnormal interpretation rate (AIR), cancer detection rate (CDR), positive predictive value of recommendation for tissue diagnosis (PPV2) and biopsy performed (PPV3), and median ..
  6. Takashima K, Matsushima M, Hashimoto K, Nose H, Sato M, Hashimoto N, et al. Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury. Respir Res. 2014;15:150 pubmed publisher
    ..We also examined the effects of quercetin on LPS stimulation in the mouse alveolar macrophage cell line, AMJ2-C11 cells. Intratracheal administration of quercetin decreased the wet lung-to-body weight ratio...
  7. Zhang S, Zhang G, Zhang L. Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer. Genet Mol Res. 2016;15: pubmed publisher
    ..Gradient concentrations of 5-Aza-CdR (5, 10, and 20 mM) were used to treat the prostate cancer cell line (LNCaP), and mRNA level of E-Cadherin was ..
  8. Kim D, Park C, Kim D, Park H, Byambaragchaa M, Lee N, et al. Production and characterization of monoclonal antibodies against recombinant tethered follicle-stimulating hormone from Japanese eel Anguilla japonica. Gen Comp Endocrinol. 2016;233:8-15 pubmed publisher
    ..Positive hybridomas (clones eFA-C5, eFA-C10, eFA-C11, eFA-C12, eFA-C13, and eFB-C14) were selected by using the eel FSH antigen in ELISA, and anti-eel FSH mAbs were ..
  9. Xiang Z, Xiao S, Wang F, Qin Y, Wu J, Ma H, et al. Cloning, characterization and comparative analysis of four death receptorTNFRs from the oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 2016;59:288-297 pubmed publisher
    ..Phylogenetic analysis showed that the ChDR proteins clustered into three distinct groups, indicating that these subfamilies had common ancestors...
  10. Kulkarni P, Dasgupta P, Bhat N, Shahryari V, Shiina M, Hashimoto Y, et al. Elevated miR-182-5p Associates with Renal Cancer Cell Mitotic Arrest through Diminished MALAT-1 Expression. Mol Cancer Res. 2018;: pubmed publisher
    ..indicate that miR-182-5p is downregulated in ccRCC; the mechanism being CpG hypermethylation as observed from 5-Aza CdR treatment that decreased promoter methylation and expression of key methylation regulatory genes like DNMT1, ..
  11. Muzik O, Reilly K, Diwadkar V. "Brain over body"-A study on the willful regulation of autonomic function during cold exposure. Neuroimage. 2018;172:632-641 pubmed publisher
    ..In addition, the Iceman also underwent a whole body PET/CT imaging session using the tracers C11-hydroxyephedrine (HED) and 18F-fluorodeoxyglucose (FDG) during both thermoneutral and prolonged mild cold ..
  12. Pelclova D, Ždímal V, Kacer P, Komarc M, Fenclova Z, Vlcková S, et al. Markers of lipid oxidative damage among office workers exposed intermittently to air pollutants including nanoTiO2 particles. Rev Environ Health. 2017;32:193-200 pubmed publisher
    ..05); only 8-isoprostane and C11 were not increased...
  13. Henning P, Burgess C, Jones H, Norman W. The effects of asking a fertility intention question in primary care settings: a systematic review protocol. Syst Rev. 2017;6:11 pubmed publisher
    ..Databases (Ovid MEDLINE; Pubmed; CINAHL; EMBASE; CDR/DARE databases; Web of Science; ISRCTN registry; Clinicaltrials...
  14. Villanueva Chimal E, Salinas L, Fernández Cardenas L, Huelgas Morales G, Cabrera Wrooman A, Navarro R. DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline. Genesis. 2017;55: pubmed publisher
    ..In Drosophila, there is only one member, dd4, whose function is still unknown, but it is expressed in many tissues and is particularly abundant in the brain of ..
  15. Cotticelli M, Crabbe A, Wilson R, Shchepinov M. Insights into the role of oxidative stress in the pathology of Friedreich ataxia using peroxidation resistant polyunsaturated fatty acids. Redox Biol. 2013;1:398-404 pubmed publisher
    ..deuterated PUFAs resulted in decreased lipid peroxidation as measured by the fluorescence of the fatty acid analog C11-BODIPY (581/591) probe...
  16. Silva A, Santos A, Farfel J, Grinberg L, Ferretti R, Campos A, et al. Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease. PLoS ONE. 2014;9:e99897 pubmed publisher
    ..AD" (CP-AD)--subjects with neuropathological AD (Braak ≥ IV and CERAD = B or C) and clinical dementia (CDR ≥ 2, IQCODE>3...
  17. Marczynska J, Banas M, Guzik K, Koltun M, Majewski P, Cichy J, et al. Chlorin e6-mediated photodynamic effect diminishes therapeutic potential of 5-aza-2'-deoxycytidine-based whole-tumour-cell vaccine in mice bearing squamous cell carcinoma SCCVII. J Photochem Photobiol B. 2015;153:455-62 pubmed publisher
    ..5-Aza-2'-deoxycytidine (5-AZA-CdR), a DNA hypomethylating drug, induces the expression of CTAs in neoplastic cells...
  18. Zoccal K, Ferreira G, Prado M, Gardinassi L, Sampaio S, Faccioli L. LTB4 and PGE2 modulate the release of MIP-1? and IL-1? by cells stimulated with Bothrops snake venoms. Toxicon. 2018;150:289-296 pubmed publisher
    ..protein 1-alpha (MIP-1?) and IL-1? production by THP-1 (cell line of human peripheral blood monocytes) and AMJ2-C11 (cell line of mouse alveolar macrophage)...
  19. Furiga A, Lajoie B, El Hage S, Baziard G, Roques C. Impairment of Pseudomonas aeruginosa Biofilm Resistance to Antibiotics by Combining the Drugs with a New Quorum-Sensing Inhibitor. Antimicrob Agents Chemother. 2015;60:1676-86 pubmed publisher
    ..In a previous study, we discovered an original QS inhibitor, N-(2-pyrimidyl)butanamide, called C11, based on the structure of C4-homoserine lactone, and found that it is able to significantly inhibit P...
  20. Korytowski W, Wawak K, Pabisz P, Schmitt J, Chadwick A, Sahoo D, et al. Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress. Arterioscler Thromb Vasc Biol. 2015;35:2104-13 pubmed publisher
    ..controls and underwent less 7-OOH-induced lipid peroxidation and membrane depolarization, as probed with C11-BODIPY (4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-inda-cene-3-undecanoic acid) and JC-1 (5,5',6,..
  21. Stapelfeld C, Maser E. Sex hormones reduce NNK detoxification through inhibition of short-chain dehydrogenases/reductases and aldo-keto reductases in vitro. Chem Biol Interact. 2017;276:167-173 pubmed publisher
    ..reduction is catalyzed by members of the AKR- and the SDR-superfamilies which include AKR1B10, AKR1C1, AKR1C2, AKR1C4, 11?-HSD1 and CBR1...
  22. Hara A, Endo S, Matsunaga T, Soda M, Yashiro K, El Kabbani O. Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily. J Biochem. 2017;162:371-379 pubmed publisher
    Four human hydroxysteroid dehydrogenases in the aldo-keto reductase (AKR) superfamily, AKR1C1-AKR1C4, are involved in the metabolism of steroids and other carbonyl compounds including drugs, and altered expression of AKRs (1C1, 1C2 and/or ..
  23. Sakusic A, O Horo J, Dziadzko M, Volha D, Ali R, Singh T, et al. Potentially Modifiable Risk Factors for Long-Term Cognitive Impairment After Critical Illness: A Systematic Review. Mayo Clin Proc. 2018;93:68-82 pubmed publisher
    ..All searches were run on October 1, 2017. The search strategy included Ovid MEDLINE, Ovid Embase, Ovid CDR, Cochrane Central Register of Controlled Trials and Database of Abstracts of Reviews of Effect, Scopus, and Web of ..
  24. DeKosky B, Lungu O, Park D, Johnson E, Charab W, Chrysostomou C, et al. Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires. Proc Natl Acad Sci U S A. 2016;113:E2636-45 pubmed publisher
    ..charge and solvent-accessible surface area; and (iv) public heavy-chain third complementarity-determining region (CDR-H3) antibodies in the antigen-experienced repertoire showed signs of convergent paired light-chain genetic ..
  25. Roncase E, Moon C, Chatterjee S, González Páez G, Craik C, O Donoghue A, et al. Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria. ACS Chem Biol. 2017;12:1556-1565 pubmed publisher
    ..Members of the clostripain-like (C11) family of cysteine proteases from commensal gut bacterial strains have recently been shown to mediate immune ..
  26. Gerretsen P, Chung J, Shah P, Plitman E, Iwata Y, Caravaggio F, et al. Anosognosia Is an Independent Predictor of Conversion From Mild Cognitive Impairment to Alzheimer's Disease and Is Associated With Reduced Brain Metabolism. J Clin Psychiatry. 2017;78:e1187-e1196 pubmed publisher
    ..HC participants had Mini-Mental State Examination (MMSE) scores from 24 to 30 and a Clinical Dementia Rating (CDR) of 0. MCI participants had MMSE scores from 24 to 30, a memory complaint, objective memory loss, a CDR of 0...
  27. Ringman J, Liang L, Zhou Y, Vangala S, Teng E, Kremen S, et al. Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. Brain. 2015;138:1036-45 pubmed publisher
    ..Inventory-Questionnaire, the 15-item Geriatric Depression Scale and the Clinical Dementia Rating Scale (CDR). Ninety-seven asymptomatic (CDR = 0), 25 mildly symptomatic (CDR = 0.5), and 33 overtly affected (CDR > 0...
  28. Adams T, Payette J, Cheah J, Movassaghi M. Concise Total Synthesis of (+)-Luteoalbusins A and B. Org Lett. 2015;17:4268-71 pubmed publisher
    ..addition to a cyclotryptophan-derived diketopiperazine, a late-stage diketopiperazine dihydroxylation, and a C11-sulfidation sequence, in addition to congener-specific polysulfane synthesis and cyclization to the corresponding ..
  29. Mathews S, Martin L, Coetzee D, Scott C, Naidoo T, Brijmohun Y, et al. The South African child death review pilot: A multiagency approach to strengthen healthcare and protection for children. S Afr Med J. 2016;106:895-9 pubmed publisher
    ..To describe the SA child death review (CDR) pilot, the pattern of child deaths reviewed and the factors associated with these deaths...
  30. Saska J, Lewis W, Paton R, Denton R. Synthesis of malhamensilipin A exploiting iterative epoxidation/chlorination: experimental and computational analysis of epoxide-derived chloronium ions. Chem Sci. 2016;7:7040-7049 pubmed publisher
    ..phosphorus(v)-mediated deoxydichlorination reactions as well a titanium-mediated epoxide-opening to construct the C11-C16 stereohexad...
  31. Valdivia A, Goicoechea S, Awadia S, Zinn A, Garcia Mata R. Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio. Mol Biol Cell. 2017;28:1768-1781 pubmed publisher
    ..So far, only Rac1 has been consistently associated with CDR formation, whereas the role of other GTPases in this process is either lacking or inconclusive...
  32. Chen T, Chou M, Lai C, Wu S, Hsu C, Yang Y. Factors affecting therapeutic response to Rivastigmine in Alzheimer's disease patients in Taiwan. Kaohsiung J Med Sci. 2017;33:277-283 pubmed publisher
    ..5% in global status, by Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score...
  33. Babut M, Labadie P, Simonnet Laprade C, Munoz G, Roger M, Ferrari B, et al. Per- and poly-fluoroalkyl compounds in freshwater fish from the Rhône River: Influence of fish size, diet, prey contamination and biotransformation. Sci Total Environ. 2017;605-606:38-47 pubmed publisher
    ..Biomagnification factor calculations showed that C11-C13 PFCAs, PFOS and FOSA were apparently biomagnified in barbels and gudgeons.
  34. Abraham W, de Carvalho M, da Costa Neves T, Memoria M, Tartuci I, Vancanneyt M, et al. Proposal of Henriciella barbarensis sp. nov. and Henriciella algicola sp. nov., stalked species of the genus and emendation of the genus Henriciella. Int J Syst Evol Microbiol. 2017;67:2804-2810 pubmed publisher
    ..cellular fatty acids were C18?:?1?7 and C16?:?0, hydroxyl-fatty acids were 3-OH C12?:?0 in both strains and 3-OH C11?:?0 in MCS23T. Strains MCS23T and MCS27T had DNA G+C contents of 57.0 and 55.0?mol%, respectively...
  35. Guo Y, Kotova E, Chen Z, Lee K, Hopper Borge E, Belinsky M, et al. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J Biol Chem. 2003;278:29509-14 pubmed
    ..We conclude that MRP8 is an amphipathic anion transporter that is able to efflux cAMP and cGMP and to function as a resistance factor for commonly employed purine and pyrimidine nucleotide analogs...
  36. Zhao Y, Raichle M, Wen J, Benzinger T, Fagan A, Hassenstab J, et al. In vivo detection of microstructural correlates of brain pathology in preclinical and early Alzheimer Disease with magnetic resonance imaging. Neuroimage. 2017;148:296-304 pubmed publisher
    ..Louis. Cognitive status was operationalized with the Clinical Dementia Rating (CDR) scale. The participants, assessed as cognitively normal (CDR=0; n=23) or with mild AD dementia (CDR=0...
  37. Haba Rubio J, Marti Soler H, Tobback N, Andries D, Marques Vidal P, Waeber G, et al. Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study. Neurology. 2017;88:463-469 pubmed publisher
    ..Participants with cognitive impairment (global Clinical Dementia Rating [CDR] scale score > 0) were compared with participants with no cognitive impairment (global CDR score = 0)...
  38. Merkle P, Irving M, Hongjian S, Ferber M, Jørgensen T, Scholten K, et al. The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed ?2-Microglobulin through Distinct Binding Sites. Biochemistry. 2017;56:3945-3961 pubmed publisher
    ..Our results demonstrate that while TCR-pMHC complex formation significantly stabilizes distinct CDR loops of the TCR, it does not trigger structural changes in receptor segments remote from the binding interface...
  39. Richter T, Janoudi G, Amegatse W, Nester Parr S. Characteristics of drugs for ultra-rare diseases versus drugs for other rare diseases in HTA submissions made to the CADTH CDR. Orphanet J Rare Dis. 2018;13:15 pubmed publisher
    ..Recognition of DURDs as a distinct subgroup of DRDs by explicitly defining DURDs based on objective criteria may facilitate the implementation of HTA assessment process that accounts for the issues associated with DURD. ..
  40. Marques C, Santos Silva C, Rodrigues C, Matos J, Moura T, Baptista M, et al. Bovine oocyte membrane permeability and cryosurvival: Effects of different cryoprotectants and calcium in the vitrification media. Cryobiology. 2018;81:4-11 pubmed publisher
    ..04). An enhanced premature zona hardening in vitrified oocytes as well as lower concentrations of the fatty acids c11:18:1 and 20:4n-6 in cumulus oocyte complexes exposed to PrOH protocols were identified...
  41. Johansson A, Nikamo P, Schalling M, Landen M. AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder. J Affect Disord. 2011;133:346-51 pubmed publisher
    ..and whether single nucleotide polymorphisms (SNPs) in gene coding for steroidogenetic enzymes (HSD3B2, SRD5A1 and AKR1C4 were coupled to previous manic irritability and/or with serum progesterone concentrations...
  42. Molina G, Esquivel M, Uribe Leitz T, Lipsitz S, Azad T, Shah N, et al. Avoidable maternal and neonatal deaths associated with improving access to caesarean delivery in countries with low caesarean delivery rates: an ecological modelling analysis. Lancet. 2015;385 Suppl 2:S33 pubmed publisher
    ..We investigated the absolute reductions in maternal and neonatal deaths if countries with low CDR increased their rates to a range of greater than 7·2% but less than or equal to 19·1%...
  43. Satou M, Kaiya H, Nishi Y, Shinohara A, Kawada S, Miyazato M, et al. Mole ghrelin: cDNA cloning, gene expression, and diverse molecular forms in Mogera imaizumii. Gen Comp Endocrinol. 2016;232:199-210 pubmed publisher
    ..mass spectrometry, we found that the mole ghrelin peptides had higher ratios of the odd-number fatty acids (C9 and C11 as much as C8) attached to the third serine residue than other vertebrate ghrelin...
  44. Shan Z, Tian R, Zhang M, Gui Z, Wu J, Ding M, et al. miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3. Oncotarget. 2016;7:78813-78826 pubmed publisher
    ..Intriguingly, treatment with the DNA methylation inhibitors 5-Aza-CdR (Aza) and 4-phenylbutyric acid (PBA) resulted in miR128-1 upregulation in both GBM cells and GSCs...
  45. Lv D, Sun R, Yu Q, Zhang X. The long non-coding RNA maternally expressed gene 3 activates p53 and is downregulated in esophageal squamous cell cancer. Tumour Biol. 2016;: pubmed
    ..DNA-demethylating agent (5-aza-2-deoxy-cytidine (5-aza-CdR)) treatment significantly increased MEG3 expression level in ESCC cells, and TCGA esophageal cancer dataset also ..
  46. Dalio R, Pinheiro H, Sodek L, Haddad C. 24-epibrassinolide restores nitrogen metabolism of pigeon pea under saline stress. Bot Stud. 2013;54:9 pubmed publisher
    ..cajan (L.) Millsp, cultivar C11, growing under salinity...
  47. Santiago P, Gasparotto F, Gebara K, Bacha F, Lívero F, Strapazon M, et al. Mechanisms underlying antiatherosclerotic properties of an enriched fraction obtained from Ilex paraguariensis A. St.-Hil. Phytomedicine. 2017;34:162-170 pubmed publisher
    ..Then, during 8 experimental weeks, rabbits received diet supplemented with 1% cholesterol (CRD). After 4 weeks of CDR, animals were redistributed into five groups (n?=?6) and treated (p.o...
  48. Sonnenschein E, Phippen C, Nielsen K, Mateiu R, Melchiorsen J, Gram L, et al. Phaeobacter piscinae sp. nov., a species of the Roseobacter group and potential aquaculture probiont. Int J Syst Evol Microbiol. 2017;67:4559-4564 pubmed publisher
    ..The predominant cellular fatty acids were C18?:?1?7c, C16?:?0, C11 methyl C18?:?1?7c and C16?:?0 2-OH, and the polar lipids comprised phosphatidylglycerol, diphosphatidylglycerol, ..
  49. Sabariego C, Coenen M, Ito E, Fheodoroff K, Scaratti C, Leonardi M, et al. Effectiveness of Integration and Re-Integration into Work Strategies for Persons with Chronic Conditions: A Systematic Review of European Strategies. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..A systematic search was conducted in MedLine, PsycINFO, CDR-HTA, CDR-DARE and Cochrane Systematic Reviews. Overall, 32 relevant publications were identified...
  50. Wang Y, Yang G, Gong J, Lu F, Diao Q, Sun J, et al. Ginseng for Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Curr Top Med Chem. 2016;16:529-36 pubmed
    ..that the effectiveness of combined treatment was inconsistent as measured by MMSE, ADAS-cog, ADAS-noncog, and CDR. No studies reported the outcomes of quality of life (QoL). The current data did not report serious adverse events...
  51. Hajek A, Brettschneider C, Ernst A, Posselt T, Wiese B, Prokein J, et al. Longitudinal predictors of informal and formal caregiving time in community-dwelling dementia patients. Soc Psychiatry Psychiatr Epidemiol. 2016;51:607-16 pubmed publisher
    ..Dementia severity was measured by the Clinical Dementia Rating (CDR)...
  52. Gao Y, Lu X. Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt/β-catenin pathway. Tumour Biol. 2016;37:1461-9 pubmed publisher
    ..We also observed that MEG3 expression can be modulated by DNA methylation by using 5-aza-CdR treatment...
  53. Turró Garriga O, Hermoso Contreras C, Olives Cladera J, Mioshi E, Pelegrín Valero C, Olivera Pueyo J, et al. Adaptation and validation of a Spanish-language version of the Frontotemporal Dementia Rating Scale (FTD-FRS). Neurologia. 2017;32:290-299 pubmed publisher
    ..and discriminant validity, and calculating the degree of agreement between the Clinical Dementia Rating scale (CDR) and FTD-FRS for FTD cases. The study included 60 patients with DFT. The mean score on the FRS was 12...
  54. Huey E, Lee S, Cheran G, Grafman J, Devanand D. Brain Regions Involved in Arousal and Reward Processing are Associated with Apathy in Alzheimer's Disease and Frontotemporal Dementia. J Alzheimers Dis. 2017;55:551-558 pubmed
    ..We identified 57 subjects with mild AD (CDR?=?1) and neuropsychiatric symptoms in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database...
  55. Al Qaraghuli M, Ferro V. Analysis of the binding loops configuration and surface adaptation of different crystallized single-domain antibodies in response to various antigens. J Mol Recognit. 2017;30: pubmed publisher
    ..Subsequently, the three sdAb classes were different in size and surface area and have shown distinguishable ability to optimize their CDR length and orientation to recognize different antigen classes.
  56. Jóźwiak S, Veggiotti P, Moreira J, Gama H, Rocha F, Soares da Silva P. Effects of adjunctive eslicarbazepine acetate on neurocognitive functioning in children with refractory focal-onset seizures. Epilepsy Behav. 2018;81:1-11 pubmed publisher
    ..to the end of maintenance period in the composite Power of Attention assessed with the Cognitive Drug Research (CDR) system...
  57. Zhang H, Yang X, Feng X, Xu H, Yang Q, Zou L, et al. Chromosome-wide gene dosage rebalance may benefit tumor progression. Mol Genet Genomics. 2018;293:895-906 pubmed publisher
    ..a lower level compared to those in adjacent normal samples, which is termed chromosome-wide gene dosage rebalance (CDR) thereafter...
  58. Chong M, Tay L, Chan M, Lim W, Ye R, Tan E, et al. Prospective longitudinal study of frailty transitions in a community-dwelling cohort of older adults with cognitive impairment. BMC Geriatr. 2015;15:175 pubmed publisher
    ..status was measured using Chinese Mini-Mental State Examination (CMMSE) and Clinical Dementia Rating-Sum of Boxes (CDR-SB) scores...
  59. Bhasuran B, Murugesan G, Abdulkadhar S, Natarajan J. Stacked ensemble combined with fuzzy matching for biomedical named entity recognition of diseases. J Biomed Inform. 2016;64:1-9 pubmed publisher
    ..Our proposed approach shows promised result of 94.66%, 89.12%, 84.10%, and 76.71% of F-measure while on evaluating training and testing set of both NCBI disease and BioCreative V CDR Corpora.
  60. Suemoto C, Ferretti Rebustini R, Rodriguez R, Leite R, Soterio L, Brucki S, et al. Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study. PLoS Med. 2017;14:e1002267 pubmed publisher
    ..Cognitive function was investigated using the Clinical Dementia Rating (CDR) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE); neuropsychiatric symptoms were ..
  61. Chen G, Yang X, Ko A, Sun X, Gao M, Zhang Y, et al. Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens. Cell Rep. 2017;19:569-583 pubmed publisher
    ..thousands of unique TCRα and TCRβ sequences and dozens of distinct complementary determining region (CDR)3α and CDR3β motifs...
  62. Mendonça N, Granic A, Mathers J, Martin Ruiz C, Wesnes K, Seal C, et al. One-Carbon Metabolism Biomarkers and Cognitive Decline in the Very Old: The Newcastle 85+ Study. J Am Med Dir Assoc. 2017;18:806.e19-806.e27 pubmed publisher
    ..at baseline, and at 3 and 5 years of follow-up and, attention-specific cognition with the Cognitive Drug Research (CDR) System at baseline, and at 1.5 and 3.0 years of follow-up...
  63. Jiang Y, Huang C, Peng Z, Han S, Li W, Zhu M, et al. Acidosis counteracts itch tachyphylaxis to consecutive pruritogen exposure dependent on acid-sensing ion channel 3. Mol Pain. 2017;13:1744806917721114 pubmed publisher
    ..Here, we report that a strong stimulation of the Mas-related G-protein-coupled receptor C11 by its agonist, Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SL-NH2) or bovine adrenal medulla 8-22 peptide, ..
  64. Green A, Hardy S, Thomas E. Synthetic approaches to the C11-C27 fragments of bryostatins. Org Biomol Chem. 2017;15:9475-9496 pubmed publisher
    ..dithianes, have been investigated for the synthesis of intermediates that are the synthetic equivalents of the C11-C27 fragments of bryostatins...
  65. Ishimaru T, Ito K, Tanaka M, Matsudomi N. Participation of cysteine 30 residue in the folding process of ovalbumin evaluated in a refolding experiment using cysteine mutants. Biochem Biophys Res Commun. 2018;495:1061-1066 pubmed publisher
    ..To confirm this, each of the four SH-mutated OVAs, in which the original SS-forming sites (C11/73/120A, C30/73/120A, C73/120/367A, and C73/120/382A) were deleted, was constructed and expressed...
  66. Utianski R, Whitwell J, Schwarz C, Senjem M, Tosakulwong N, Duffy J, et al. Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech. Cortex. 2018;99:358-374 pubmed publisher
    ..Fourteen PPAOS patients underwent [18F]AV-1451 PET (tau-PET) imaging, [C11] Pittsburgh Compound B (PiB) PET and structural MRI and were matched 3:1 by age and sex to 42 cognitively normal ..
  67. Chen R, Zhang L, Qi J, Zhang N, Zhang L, Yao S, et al. Discovery and Analysis of Invertebrate IgVJ-C2 Structure from Amphioxus Provides Insight into the Evolution of the Ig Superfamily. J Immunol. 2018;200:2869-2881 pubmed publisher
    ..The first domain shows typical V folding, including the hydrophobic core, CDR analogs, and eight conserved residues...
  68. Ruiz F, Porté S, Gallego O, Moro A, Ardèvol A, del Rio Espinola A, et al. Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily. Biochem J. 2011;440:335-44 pubmed publisher
    Human AKR (aldo-keto reductase) 1C proteins (AKR1C1-AKR1C4) exhibit relevant activity with steroids, regulating hormone signalling at the pre-receptor level...
  69. Baek D, Kim Y. Humanization of a phosphothreonine peptide-specific chicken antibody by combinatorial library optimization of the phosphoepitope-binding motif. Biochem Biophys Res Commun. 2015;463:414-20 pubmed publisher
    ..Using a yeast surface-displayed combinatorial library with permutations of 11 FR residues potentially affecting CDR loop conformations, we identified 5 critical FR residues...
  70. Oliver Rodríguez B, Zafra Gómez A, Reis M, Duarte B, Verge C, de Ferrer J, et al. Wide-range and accurate modeling of linear alkylbenzene sulfonate (LAS) adsorption/desorption on agricultural soil. Chemosphere. 2015;138:148-55 pubmed publisher
    ..isotherms were determined through batch studies for total LAS amount and also for each homologue series: C10, C11, C12 and C13...
  71. Cobo A, Garrido N, Pellicer A, Remohí J. Six years' experience in ovum donation using vitrified oocytes: report of cumulative outcomes, impact of storage time, and development of a predictive model for oocyte survival rate. Fertil Steril. 2015;104:1426-34.e1-8 pubmed publisher
    ..None. Survival rate per warming procedure, cumulative delivery rates (CDR) per single donation cycle, oocyte-to-baby rate, and cumulative live birth rate (CLBR) per oocyte consumed...
  72. Iwamoto N, Shimada T, Terakado H, Hamada A. Validated LC-MS/MS analysis of immune checkpoint inhibitor Nivolumab in human plasma using a Fab peptide-selective quantitation method: nano-surface and molecular-orientation limited (nSMOL) proteolysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1023-1024:9-16 pubmed publisher
    ..The signature peptide ASGITFSNSGMHWVR from Nivolumab complementarity-determining region (CDR) and the P14R internal standard were simultaneously quantified by multiple-reaction monitoring (MRM) LCMS, with ..
  73. Tafess K, Mengistu B, Woldeyohannes D, Sisay S. Determining treatment outcome of smear-positive pulmonary tuberculosis cases in Afar Regional State, Ethiopia: A retrospective facility based study. Int J Mycobacteriol. 2016;5:164-9 pubmed publisher
    ..7%) smear-negative pulmonary TB, and 9838 (28.2%) extrapulmonary TB. The case detection rate (CDR) of smear-positive pulmonary TB had increased from 18.3% to 37...
  74. Park H, Park K, Yoon B, Lee J, Choi S, Joung J, et al. Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes. J Neurol Sci. 2017;372:51-56 pubmed publisher
    ..SD patients with parkinsonism had higher CDR sum of boxes scores (9.7±4.5 vs 6.2±4.5, p=0.024), frontal behavioral inventory total score (33.7±20.5 vs 24...
  75. Sarvari K, Sóki J, Iván M, Miszti C, Latkóczy K, Melegh S, et al. Detection of enterotoxin and protease genes among Hungarian clinical Bacteroides fragilis isolates. Anaerobe. 2017;48:98-102 pubmed publisher
    ..Recently it has been shown that a member of C11 proteases called fragipain (fpn) can activate the enterotoxin, while C10 protease (bfp) is suspected of playing an ..
  76. van Rossum M, Koek H. Predictors of functional disability in mild cognitive impairment and dementia. Maturitas. 2016;90:31-6 pubmed publisher
    ..03, 95%CI=0.002-0.05), gender (B=-0.43, 95%CI=-0.78 to -0.07), score on the Clinical Dementia Rating scale (CDR) (B=1.53, 95%CI=1.07-1.99 for CDR 1, B=2.93, 95%CI=2.28-3.58 for CDR 2, B=3.96, 95%CI=2.65-5...
  77. Marr K, Lyons C, Rustad T, Bowden R, White T, Rustad T. Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR. Antimicrob Agents Chemother. 1998;42:2584-9 pubmed
    ..the ergosterol biosynthesis pathway (ERG7, ERG9, and ERG11) and genes encoding efflux pumps (MDR1, ABC1, YCF, and CDR), revealed that azole resistance in this series is associated with increased mRNA levels for members of the ATP ..
  78. Dufort I, Labrie F, Luu The V. Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. J Clin Endocrinol Metab. 2001;86:841-6 pubmed
  79. Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, et al. Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. Pharmacogenetics. 2003;13:49-53 pubmed
    ..factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and HNF-4 gamma were essential for the expression of DD4 mRNA, which is a major form of DDs...
  80. Schule C, Romeo E, Uzunov D, Eser D, di Michele F, Baghai T, et al. Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. Mol Psychiatry. 2006;11:261-72 pubmed
    ..However, the changes in neuroactive steroid concentrations more likely reflect direct pharmacological effects of this antidepressant rather than clinical improvement in general. ..
  81. Davies N, Hayden R, Simpson P, Birtwistle J, Mayer K, Ride J, et al. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res. 2009;69:4769-75 pubmed publisher
    ..In conclusion, we have identified AKR1C isoforms as a novel target of jasmonates in cancer cells and provide further evidence of the promise of these compounds, or derivatives thereof, as adjunctive therapies in the treatment of cancer. ..
  82. Toyoda Y, Takada T, Gomi T, Nakagawa H, Ishikawa T, Suzuki H. Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis. Int J Mol Sci. 2017;18: pubmed publisher
    ..is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ATP-binding cassette C11 (ABCC11) gene...
  83. Zachariah S, Das S. Idiomarina andamanensis sp. nov., an alkalitolerant bacterium isolated from Andaman Sea water. Antonie Van Leeuwenhoek. 2017;110:1581-1592 pubmed publisher
    ..DNA G+C content was 46.7 mol%. Major fatty acids were iso-C15:0, iso-C17:0, iso-C17:1 ?9c, iso-C13:0 3OH, iso-C11:0 3OH and C16:0...
  84. Dufouil C, Dubois B, Vellas B, Pasquier F, Blanc F, Hugon J, et al. Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort. Alzheimers Res Ther. 2017;9:67 pubmed publisher
    ..5 SD below age, sex and education-level norms) while not demented (Clinical Dementia Rating [CDR] <1)...
  85. Entzminger K, Hyun J, Pantazes R, Patterson Orazem A, Qerqez A, Frye Z, et al. De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide. Sci Rep. 2017;7:10295 pubmed publisher
    ..Here, we employed de novo complementarity determining region (CDR) design to engineer targeted antibody-antigen interactions using previously described in silico methods...
  86. Zeng M, Murphy S, Herzon S. Development of a Modular Synthetic Route to (+)-Pleuromutilin, (+)-12-epi-Mutilins, and Related Structures. J Am Chem Soc. 2017;139:16377-16388 pubmed publisher
    ..coupling reaction with an organolithium reagent derived from the alkyl iodides (R)- or (S)-30, which contain the C11-C13 atoms of the target, to provide diastereomeric diketones in 60% or 48% yield (for coupling with (R)- or (S)-30, ..
  87. Perez Garcia O, Mankelow C, Chandran K, Villas Boas S, Singhal N. Modulation of Nitrous Oxide (N2O) Accumulation by Primary Metabolites in Denitrifying Cultures Adapting to Changes in Environmental C and N. Environ Sci Technol. 2017;: pubmed publisher
    ..028) N2O accumulation (8.5.3 ± 0.9% of the total nitrogen added), which was linked to the depletion of C11-C20 fatty acids...
  88. Shaban E, Switalska M, Wang L, Wang N, Xiu F, Hayashi I, et al. Synthesis and In Vitro Antiproliferative Activity of 11-Substituted Neocryptolepines with a Branched ?-Aminoalkylamino Chain. Molecules. 2017;22: pubmed publisher
    ..evaluation of several neocryptolepine analogues carrying a branched, functionalized dibasic side chain at C11. These 2-substituted 5-methyl-indolo[2,3-b]quinoline derivatives were prepared by nucleophilic aromatic ..
  89. Ahmed S, Gull A, Alam M, Aqil M, Sultana Y. Ultrasonically tailored, chemically engineered and "QbD" enabled fabrication of agomelatine nanoemulsion; optimization, characterization, ex-vivo permeation and stability study. Ultrason Sonochem. 2018;41:213-226 pubmed publisher
    ..The experimental values for dependent variables such as hydrodynamic diameter (nm), % transmittance and % CDR were found to be 73.72±2.53nm, 98.2±0.42%, 84.71±4.05% respectively...
  90. Boshkow J, Fischer S, Bailey A, Wolfrum S, Carreira E. Stereochemistry and biological activity of chlorinated lipids: a study of danicalipin A and selected diastereomers. Chem Sci. 2017;8:6904-6910 pubmed publisher
    ..diastereomer 2 showed similar behavior to natural (+)-danicalipin A (1), strikingly, the more flexible C11,C15-epimer 3 had no effect on permeability and proved equally or more toxic towards multiple cell lines.
  91. Zhao Q, Buhr D, Gunter C, Frenette J, Ferguson M, Sanford E, et al. Rational library design by functional CDR resampling. N Biotechnol. 2018;45:89-97 pubmed publisher
    ..Our study indicated that predefined CDR sequences with optimized CDR-framework compatibility could be a productive direction of functional library ..
  92. Winters C, Molowa D, Guzelian P. Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. Biochemistry. 1990;29:1080-7 pubmed
    ..This reaction is controlled by a cytosolic enzyme, chlordecone reductase (CDR), which may be of the aldo-keto reductase family of xenobiotic metabolizing enzymes [Molowa et al. (1986) J. Biol...