AKR1C4

Summary

Gene Symbol: AKR1C4
Description: aldo-keto reductase family 1 member C4
Alias: 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, aldo-keto reductase family 1 member C4, 3-alpha-HSD1, chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4, dihydrodiol dehydrogenase isozyme DD4, type I 3-alpha-hydroxysteroid dehydrogenase
Species: human

Top Publications

  1. ncbi Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene
    Takeshi Ozeki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060 0812, Hokkaido, Japan
    Arch Biochem Biophys 405:185-90. 2002
  2. ncbi Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers
    Takeshi Ozeki
    Laboratory of Drug Metabolism, Division of Pharmacobio dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Pharmacogenetics 13:49-53. 2003
  3. pmc Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha
    T Ozeki
    Laboratory of Drug Metabolism, Hokkaido University Graduate School of Pharmaceutical Sciences, Sapporo, Hokkaido 060 0812, Japan
    Biochem J 355:537-44. 2001
  4. ncbi Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver
    T Kume
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Pharmacogenetics 9:763-71. 1999
  5. ncbi Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution
    I Dufort
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Clin Endocrinol Metab 86:841-6. 2001
  6. pmc Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members
    T O'CONNOR
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U K
    Biochem J 343:487-504. 1999
  7. ncbi An inactive pancreatic lipase-related protein is activated into a triglyceride-lipase by mutagenesis based on the 3-D structure
    S Bezzine
    , CNRS-IFR1 UPR9039, Marseille, France
    Chem Phys Lipids 93:103-14. 1998
  8. ncbi An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers
    K A Ellis
    Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria, Australia
    Behav Pharmacol 12:173-82. 2001
  9. pmc Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    T M Penning
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Biochem J 351:67-77. 2000
  10. ncbi Dementia and work load evaluation of the elderly
    H A Nygaard
    Fyllingsdalen Sykehjem, Bergen, Norway
    Compr Gerontol A 1:65-8. 1987

Research Grants

  1. Radioimmunotherapy: An Anti-Neoplastic Strategy
    Andres Forero; Fiscal Year: 2006
  2. Role of IG CDR-H3 in Responses to HIV Vaccines
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2013
  3. Andrew D Weinberg; Fiscal Year: 2014
  4. A novel pre-defined CDR library for selection of affinity reagents
    Michael P Weiner; Fiscal Year: 2013
  5. Mark J Young; Fiscal Year: 2014
  6. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David R Clemmons; Fiscal Year: 2010
  7. Mucosal Immune Ontogeny and Intestinal Microbiota in Infants
    Edward N Janoff; Fiscal Year: 2010
  8. Jason T Kimata; Fiscal Year: 2015
  9. Immunoglobulin CDR-H3 and neutralizing antibodies to HIV
    Harry Schroeder; Fiscal Year: 2009
  10. PROTEOLYTIC ANTIBODIES FOR TREATMENT OF PSORIASIS
    ROBERT BALINT; Fiscal Year: 2009

Detail Information

Publications266 found, 100 shown here

  1. ncbi Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene
    Takeshi Ozeki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060 0812, Hokkaido, Japan
    Arch Biochem Biophys 405:185-90. 2002
    ..activation of the human dihydrodiol dehydrogenase (DD)4 gene in human hepatoblastoma HepG2 cells, which express DD4 mRNA...
  2. ncbi Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers
    Takeshi Ozeki
    Laboratory of Drug Metabolism, Division of Pharmacobio dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Pharmacogenetics 13:49-53. 2003
    ..factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and HNF-4 gamma were essential for the expression of DD4 mRNA, which is a major form of DDs...
  3. pmc Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha
    T Ozeki
    Laboratory of Drug Metabolism, Hokkaido University Graduate School of Pharmaceutical Sciences, Sapporo, Hokkaido 060 0812, Japan
    Biochem J 355:537-44. 2001
    ..To investigate the mechanism of transcriptional regulation of the human DD4 gene, the 5'-flanking region of the gene was fused to the luciferase gene...
  4. ncbi Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver
    T Kume
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Pharmacogenetics 9:763-71. 1999
    ..The results substantiate the existence of polymorphic forms for human liver DD, and also suggest the importance of the residue at position 311 for substrate binding to the enzyme...
  5. ncbi Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution
    I Dufort
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Clin Endocrinol Metab 86:841-6. 2001
    ....
  6. pmc Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members
    T O'CONNOR
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U K
    Biochem J 343:487-504. 1999
    ..reductase (AKR1A1), aldose reductase (AKR1B1), dihydrodiol dehydrogenase 1 (AKR1C1) and chlordecone reductase (AKR1C4) have been expressed in Escherichia coli...
  7. ncbi An inactive pancreatic lipase-related protein is activated into a triglyceride-lipase by mutagenesis based on the 3-D structure
    S Bezzine
    , CNRS-IFR1 UPR9039, Marseille, France
    Chem Phys Lipids 93:103-14. 1998
    ..of enzymatic activity by inducing a steric clash with one of the acyl chain observed in the structures of chiral C11 alkyl phosphonate inhibitors, bound to the classical PL...
  8. ncbi An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers
    K A Ellis
    Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria, Australia
    Behav Pharmacol 12:173-82. 2001
    ..Twelve healthy young subjects completed the Cognitive Drug Research (CDR) memory battery, following administration of placebo, 900 mg and 1800 mg hypericum (Blackmore's Hyperiforte)...
  9. pmc Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    T M Penning
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Biochem J 351:67-77. 2000
    ..The enzymes correspond to type 1 3alpha-HSD (AKR1C4), type 2 3alpha(17beta)-HSD (AKR1C3), type 3 3alpha-HSD (AKR1C2) and 20alpha(3alpha)-HSD (AKR1C1), and share at ..
  10. ncbi Dementia and work load evaluation of the elderly
    H A Nygaard
    Fyllingsdalen Sykehjem, Bergen, Norway
    Compr Gerontol A 1:65-8. 1987
    ..Mental status was estimated by means of the Clinical Dementia Rating scale (CDR), and work load by means of a traditional work load scale...
  11. ncbi Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma
    Johan M Kros
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 97:1390-6. 2002
    ..genes by polymerase chain reaction (PCR) to the framework region (FR)3 and FR2 complementarity determining region (CDR)-III and CDR-II of these genes...
  12. ncbi Alkyl nitrates as achiral and chiral solute probes in gas chromatography. Novel properties of a beta-cyclodextrin derivative and characterization of its enantioselective forces
    M Schneider
    Tularik Inc, South San Francisco, CA 94080, USA
    J Chromatogr A 852:525-34. 1999
    ..Secondly, the chiral separations of systematically varied sets of C4-C11 alkyl nitrates allowed the thermodynamic characterization of enantiodiscriminating interactions...
  13. ncbi Potentiation of myeloid differentiation by anti-inflammatory agents, by steroids and by retinoic acid involves a single intracellular target, probably an enzyme of the aldoketoreductase family
    C M Bunce
    Department of Immunology, University of Birmingham, Edgbaston, UK
    Biochim Biophys Acta 1311:189-98. 1996
    ....
  14. doi Characteristics of disc hemorrhage in primary angle-closure glaucoma
    Yu Wen Lan
    Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan
    Ophthalmology 115:1328-33, 1333.e1. 2008
    ..To analyze the characteristics of disc hemorrhage in primary angle-closure glaucoma (PACG)...
  15. ncbi Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake
    Elaine M Leslie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 69:629-39. 2006
    ..In the current study, Cd(2+)-resistant MT(-/-) (CdR) and CdR revertant (CdR-rev) cell lines were developed and characterized to investigate non-MT-mediated cellular ..
  16. ncbi The Cohen diabetic (non-insulin-dependent) hypertensive rat model. Description of the model and pathologic findings
    A M Cohen
    Department of Medicine, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Am J Hypertens 6:989-95. 1993
    ..here a genetic type II diabetic hypertensive model (CDHM) developed by cross breeding the Cohen diabetic rat (CDR) and the SHR...
  17. ncbi Determination of linear alkylbenzenesulfonates in wastewater treatment plants and coastal waters by automated solid-phase extraction followed by capillary electrophoresis-UV detection and confirmation by capillary electrophoresis-mass spectrometry
    J Riu
    Department of Environmental Chemistry, IIQAB-CSIC, Barcelona, Spain
    J Chromatogr A 889:221-9. 2000
    ..ions were the same ones used in LC-electrospray (ESI) MS and corresponded to m/z 297, 311, 325 and 339 for C10, C11, C12 and C13 LASs, respectively...
  18. pmc Picosecond time-resolved absorption and fluorescence dynamics in the artificial bacteriorhodopsin pigment BR6.11
    T L Brack
    Department of Chemistry, University of Arizona, Tucson 85721
    Biophys J 65:964-72. 1993
    ..BR) pigment containing a structurally modified all-trans retinal chromphore with a six-membered ring bridging the C11=C12-C13 positions (BR6...
  19. ncbi Evolution of blood pressure in patients with Alzheimer's disease: a one year survey of a French Cohort (REAL.FR)
    O Hanon
    Department of Geriatrics, Hopital Broca, 75013 Paris, France
    J Nutr Health Aging 9:106-11. 2005
    ..To determine the evolution of blood pressure in patients with moderate Alzheimer's disease among a one year longitudinal survey and to evaluate the relationship between blood pressure and cognitive functions...
  20. ncbi Diagnostic strategy using a modified clinical decision rule and D-dimer test to rule out pulmonary embolism in elderly in- and outpatients
    Maaike Sohne
    Academic Medical Center, Department of Vascular Medicine, Room F4 136, Meibergdreef 9, 1105 AZ Amsterdam
    Thromb Haemost 94:206-10. 2005
    ..The safety and efficacy of the combination of a clinical probability (CDR) and d-dimer test in excluding pulmonary embolism in this group is unclear...
  21. doi Cognitive changes after parathyroidectomy in patients with secondary hyperparathyroidism
    Fong Fu Chou
    Department of Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Surgery 143:526-32. 2008
    ..Cognitive impairment was frequently reported in uremic patients with dialysis, but improvements of cognition after parathyroidectomy for symptomatic secondary hyperparathyroidism have never been reported before...
  22. ncbi [5-aza-2'-deoxycytidine induces changes of histone H3-lysine 9 methylation in bladder tumor cells]
    Na Yang
    Department of Clinical Laboratory Medicine, Shanghai Tenth People s Hospital, Tongji University, Shanghai 200072, China
    Zhonghua Yi Xue Za Zhi 88:2295-8. 2008
    To investigate the effect of DNA methyltransferases inhibitor 5-aza-2'-deoxycytidine (5-Aza-CdR) on the histone H3-lysine 9 methylation status and gene expression of RUNX3 in human bladder tumor cells.
  23. ncbi Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline
    Dietmar Rudolf Thal
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    J Neuropathol Exp Neurol 62:1287-301. 2003
    ..We correlated the clinical dementia rating (CDR) score, the sequential extension of AD-related A beta deposition into different parts of the brain, and the ..
  24. pmc Orbital fracture clinical decision rule development: burden of disease and use of a mandatory electronic survey instrument
    Kabir Yadav
    Department of Emergency Medicine, The George Washington University, Washington, DC, USA
    Acad Emerg Med 18:313-6. 2011
    In preparation for development of a clinical decision rule (CDR) to promote more efficient use of computed tomography (CT) for diagnosing orbital fractures, the authors sought to estimate the annual incidence of orbital fractures in ..
  25. ncbi Combination of a thiazide, a vasodilator and reserpine compared with methyldopa plus hydrochlorothiazide in the treatment of hypertension in Zimbabwe
    C M Stein
    Department of Clinical Pharmacology, University of Zimbabwe, Harare
    S Afr Med J 77:243-5. 1990
    ..5 mg) and reserpine (0.1 mg) (CDR) was compared with methyldopa (MD) plus hydrochlorothiazide (HCT) for antihypertensive effect, adverse reactions, ..
  26. ncbi Non-neurological factors are implicated in impairments in gait and mobility among patients in a clinical dementia referral population
    Vince Salazar Thomas
    Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Int J Geriatr Psychiatry 17:128-33. 2002
    ..Gait disorders were very prevalent at each level of cognitive function [58.7% for CDR=0, 68.0% for CDR=0.5, 57.9% for CDR=1, 68.1% for CDR=2 and 76.9% for CDR=3, p=0...
  27. ncbi Urban and rural differences in mortality and causes of death in historical Poland
    Alicja Budnik
    Department of Anthropology, Adam Mickiewicz University, 61 614 Poznan, Poland
    Am J Phys Anthropol 129:294-304. 2006
    ..Mortality measures such as crude death rate (CDR), infant death rate (IDR), and neonatal and postneonatal death rates were calculated...
  28. ncbi The increased flexibility of CDR loops generated in antibodies by Congo red complexation favors antigen binding
    Marcin Krol
    Dept of Bioinformatics and Telemedicine, Medical College, Jagiellonian University, Kopernika 17, 31 501 Krakow, Poland
    J Biomol Struct Dyn 23:407-16. 2006
    ..The higher fluctuation of CDR-bearing loops enhances antigen binding, and allows even low-affinity antibodies to be engaged in immune complexes...
  29. ncbi Interaction of lysozyme with synthetic anti-lysozyme D1.3 antibody fragments studied by affinity chromatography and surface plasmon resonance
    E Lasonder
    Laboratory of Medical Microbiology, University of Groningen, Netherlands
    J Chromatogr A 676:91-8. 1994
    ..3 show interaction with lysozyme. Surface plasmon resonance with immobilized CDR peptides showed that this interaction is not based on the antigen-antibody interaction...
  30. ncbi Isolation and partial characterization of a full-length cDNA clone for 3 alpha-hydroxysteroid dehydrogenase: a potential target enzyme for nonsteroidal anti-inflammatory drugs
    J Pawlowski
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104 6084
    Agents Actions 34:289-93. 1991
    ..These findings support the role 3 alpha-HSD in inflammation and suggest that hydroxysteroid dehydrogenases, hydroxyprostaglandin dehydrogenases and prostaglandin F2 alpha synthase may be members of a common gene family...
  31. ncbi [A longitudinal study of the course of Alzheimer type dementia]
    J A Tellería-Díaz
    Hospital Clinico Quirurgico Hermanos Ameijeiras, La Habana, Cuba
    Rev Neurol 25:1551-6. 1997
    ..We carried out a prospective longitudinal study of 41 patients diagnosed as probably having a mild form of Alzheimer's disease according to the data of an investigation of prevalence done in 1991 in the municipality of Habana Vieja...
  32. doi Analysis of paediatric drowning deaths in Washington State using the child death review (CDR) for surveillance: what CDR does and does not tell us about lethal drowning injury
    Linda Quan
    University of Washington School of Medicine, Seattle, USA
    Inj Prev 17:i28-33. 2011
    Drowning is second cause of paediatric injury death in Washington State. Child death review (CDR) data provide the unique opportunity to identify regional risk factors and opportunities for drowning prevention.
  33. ncbi [Effects and mechanisms of 5-aza-2'-deoxycytidine on endometrial cancer cell.]
    Yu Quan Zhang
    Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong 226000, China Email
    Zhonghua Fu Chan Ke Za Zhi 44:861-4. 2009
    To investigate the effects and mechanisms of 5-aza-2'-deoxycytidine (5-Aza-CdR) on endometrial cancer cell.
  34. ncbi Using the cost distribution report in estimating private sector payments: what adjustments should researchers make?
    Gary Nugent
    Nebraska Western Iowa Health Care System, Omaha, NE, USA
    Med Care 41:II80-90. 2003
    ..To reapportion Veterans Health Administration (VA) annual expenditures into benefit categories for comparison with estimated payments by private sector providers...
  35. ncbi Corpus callosum atrophy, white matter lesions, and frontal executive dysfunction in normal aging and Alzheimer's disease. A community-based study: the Tajiri Project
    Kenichi Meguro
    Division of Neuropsychology, Department of Disability Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int Psychogeriatr 15:9-25. 2003
    ..We investigated the relationship between CC atrophy, WMH, and hippocampal atrophy, together with frontal executive dysfunction in both normal aging and AD...
  36. ncbi 5-HT2A/2C receptor and 5-HT transporter densities in mice prone or resistant to chronic high-fat diet-induced obesity: a quantitative autoradiography study
    Xu Feng Huang
    Molecular Neurobiology Laboratory, Smart Food Center, Department of Biomedical Science, University of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia
    Brain Res 1018:227-35. 2004
    ..receptors and 5-HT transporters in the brains of chronic high-fat diet-induced obese (cDIO) and obese-resistant (cDR) mice. Thirty-five male mice were used in this study...
  37. ncbi Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications
    Ester Fonsatti
    Division of Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy
    Clin Cancer Res 13:3333-8. 2007
    To investigate the potential of the DNA hypomethylating agent 5-aza-2'-deoxycytidine (5-aza-CdR) to improve the effectiveness of immunotherapeutic approaches against melanocyte differentiation antigens.
  38. pmc New methods for estimating the tuberculosis case detection rate in high-HIV prevalence countries: the example of Kenya
    John Mansoer
    US Department of Health and Human Services, Centers for Disease Control and Prevention, Nairobi, Kenya
    Bull World Health Organ 87:186-92, 192A-192B. 2009
    To develop new methods for estimating the sputum smear-positive tuberculosis case detection rate (CDR) in a country where infection with HIV is prevalent.
  39. doi Determinants of deforestation in Nepal's Central Development Region
    Keshav Bhattarai
    Department of Geography, University of Central Missouri, Warrensburg, MO 64093, USA
    J Environ Manage 91:471-88. 2009
    The process of deforestation in the Central Development Region (CDR) of Nepal is diverse in space and time, with rapid deforestation still occurring in areas outside the national parks and wildlife reserves...
  40. doi 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase
    Noel J M Raynal
    Service of Hematology and Oncology, Université de Montréal and Centre de Recherche, CHU Saint Justine, 3175 Ste Catherine Road, Montreal, Quebec, H3T 1C5 Canada
    Leuk Res 35:110-8. 2011
    ..methylation plays an important role in leukemogenesis of ALL, it can be targeted by 5-aza-2'-deoxycytidine (5-AZA-CdR), a potent inhibitor of DNA methylation. 5-AZA-CdR is a prodrug that is activated by deoxycytidine kinase (DCK)...
  41. ncbi Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase
    J E Pawlowski
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104 6084
    J Biol Chem 266:8820-5. 1991
    ..M., Abrams, W. R., and Pawlowski, J. E. (1991) J. Biol. Chem. 266, 8826-8834]. The sequence data presented suggests that 3 alpha-HSD, prostaglandin F synthase, and aldehyde/aldose reductases are members of a common gene family...
  42. ncbi A novel monoclonal antibody design for radioimmunotherapy
    Andres Forero
    Department of Medicine, Division of Hematology Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biother Radiopharm 18:751-9. 2003
    The generation of chimeric and complementary-determining region (CDR) grafted monoclonal antibodies (MAb) have reduced the immunogenicity problem in the clinical application of radioimmunotherapy with monoclonal antibodies...
  43. pmc Utility of the clinical dementia rating in Asian populations
    Wee Shiong Lim
    Department of Geriatric Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
    Clin Med Res 5:61-70. 2007
    ..The Clinical Dementia Rating (CDR) is an informant-based global assessment scale with established reliability and validity that has been widely ..
  44. doi Biochemical markers in persons with preclinical familial Alzheimer disease
    J M Ringman
    UCLA Department of Neurology, Alzheimer Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
    Neurology 71:85-92. 2008
    ..Persons at risk for familial Alzheimer disease (FAD) provide a model in which biomarkers can be studied in presymptomatic disease...
  45. ncbi Medicine reimbursement recommendations in Canada, Australia, and Scotland
    Joel Lexchin
    School of Health Policy and Management, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Manag Care 14:581-8. 2008
    This study was undertaken to compare the recommendations made by the Canadian Common Drug Review (CDR) regarding whether drugs should be listed on provincial and federal formularies with recommendations made by similar bodies in other ..
  46. pmc Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region
    Gilad Ofek
    Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 84:2955-62. 2010
    ..Here, we mutationally alter a hydrophobic patch on the third complementarity-determining region of the heavy chain (CDR H3) of the 2F5 antibody and assess the abilities of altered 2F5 variants to bind gp41 and to neutralize diverse ..
  47. ncbi Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations
    Vlastimil Král
    Department of Recombinant Expression and Structural Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 166 37 Prague, Czech Republic
    Proteins 71:1275-87. 2008
    ..of the crystal structures of free Fab M75 and its complex with the epitope peptide reveal major readjustments of CDR-H1 and CDR-H3...
  48. ncbi Neodictyoprolenol and dictyoprolenol, the possible biosynthetic intermediates of dictyopterenes, in the Japanese brown algae Dictyopteris
    Y Yamamoto
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Japan
    Z Naturforsch C 56:6-12. 2001
    ..latiscula, and in D. undulata, together with the C11-related volatile compounds such as neodictyoprolene, dictyoprolene and dictyopterenes. Incubation of D...
  49. ncbi Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase
    B P Schlegel
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104 6084
    Biochemistry 33:10367-74. 1994
    ..In the presence and absence of NAD+, 2 and 4 inactivated > 50% of the enzyme in 10 s or less.(ABSTRACT TRUNCATED AT 250 WORDS)..
  50. ncbi Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity
    Xu Feng Huang
    Department of Biomedical Science, Molecular Neurobiology Laboratory, University of Wollongong, NSW2522, Australia
    Brain Res Mol Brain Res 135:150-61. 2005
    ..and tyrosine hydroxylase (TH) mRNA expression in chronic high-fat diet-induced obese (cDIO) and obese-resistant (cDR) mice...
  51. ncbi Behavioral and psychological symptoms of dementia characteristic of mild Alzheimer patients
    Jin Shimabukuro
    Department of Psychiatry, Tohoku University Hospital, Sendai, Japan
    Psychiatry Clin Neurosci 59:274-9. 2005
    ..BPSD) in patients with mild Alzheimer's disease (AD), BPSD among the severities of Clinical Dementia Rating (CDR) in 74 patients with AD were compared using the Neuropsychiatric inventory (NPI)...
  52. ncbi An audit of intra-oral digital radiographs for endodontics
    R Austin
    Department of Primary Dental Care, King s College London Dental Institute, London, UK
    Int Endod J 43:351. 2010
    ..There were three phases. The first phase compared the Schick CDR system with Digora Optime...
  53. pmc Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo
    Bushra Ateeq
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Neoplasia 10:266-78. 2008
    The mechanism of action of DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR), a potential anticancer agent is believed to be activated by the demethylation of tumor suppressor genes...
  54. ncbi Crystal structure of human prostaglandin F synthase (AKR1C3)
    Junichi Komoto
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, Kansas 66045 7534, USA
    Biochemistry 43:2188-98. 2004
    ..Since the substrate binding cavity of PGFS is relatively large in comparison with those of AKR1C1 and AKR1C2, PGFS (AKR1C3) could catalyze the reduction and/or oxidation reactions of various compounds over a relatively wide pH range...
  55. ncbi Evaluation of a data warehouse in an academic health sciences center
    J R Schubart
    Department of Health Evaluation Sciences, University of Virginia School of Medicine, P O Box 800717, Charlottesville, VA 22908 0717, USA
    Int J Med Inform 60:319-33. 2000
    The Clinical data repository (CDR) at the University of Virginia Health System is a data warehouse that provides direct access to data for clinical research and effective decision making...
  56. pmc Shear stress-induced volume decrease in C11-MDCK cells by BK-alpha/beta4
    J David Holtzclaw
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, 68198 5850, USA
    Am J Physiol Renal Physiol 299:F507-16. 2010
    ..We determined by Western blot and immunocytochemical analysis that C11-Madin-Darby canine kidney cells contained a predominance of BK-alpha/beta4...
  57. ncbi The clinical dementia rating sum of box score in mild dementia
    C A Lynch
    Mercer s Institute for Research on Ageing, St James s Hospital, Dublin, Ireland
    Dement Geriatr Cogn Disord 21:40-3. 2006
    ..The Clinical Dementia Rating (CDR) scale is a widely used dementia staging instrument, yielding a global score and a summated score (sum of box score)..
  58. ncbi Decreased response of osteoblasts obtained from aged Cohen diabetic sensitive rats to sex steroid hormones and 1,25OH2D3 in culture
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, P O B 12272, 91120 Jerusalem, Israel
    Odontology 94:38-43. 2006
    ..The Cohen diabetic model consists of a diabetic-sensitive strain [CDs; diabetic] and a diabetic-resistant strain [CDr; normal])...
  59. ncbi [Effect of a methylation inhibitor 5-aza-2'-deoxycytidine on SHP-1 gene expression, proliferation and apoptosis in K562 cells]
    Jian Min Luo
    Department of Hematology, Hebei Medical University Shijiazhuang 050000, Hebei Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:309-14. 2009
    The aim of this study was to investigate the regulation of 5-aza-CdR on transcription of SHP-1 gene and effects on the proliferation and apoptosis of K562 cells...
  60. ncbi Mechanism for the decrease in the accumulation of cadmium (Cd) in Cd-resistant Chinese hamster V79 cells
    N Tsuchiya
    Department of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
    Arch Toxicol 68:325-31. 1994
    The mechanism for the decrease in the accumulation of cadmium (Cd) in Cd-resistant Chinese hamster V79 (Cdr) cells in culture was investigated in a comparison with Cd-sensitive (Cds) cells...
  61. ncbi 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia
    Karin Schmelz
    Department of Hematology and Oncology, Universitatsmedizin Berlin, Charite, Campus Virchow, Berlin, Germany
    Int J Cancer 114:683-95. 2005
    The DNA methylation inhibitor 5-Aza-2'-deoxycytidine (5-Aza-CdR) has significant therapeutic value for the treatment of patients with myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML)...
  62. ncbi An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment
    Haiying Wang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing, China
    J Biol Chem 283:2564-74. 2008
    ..was investigated in the human cancer cell lines A549 and HCT116 in response to 5-aza-2'-deoxycytidine (5-aza-CdR) or cytarabine treatment...
  63. ncbi [Effect of (-)-epigallocatechin-3-gallate and 5-AZA-CdR on expression of X-linked inhibitor of apoptosis protein-associated factor 1 in human leukemia HL-60 and K562 cells]
    Yun yan Huang
    Department of Pediatrics, College of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:204-8. 2008
    ..factor 1 (Xaf1) in human leukemia HL-60 and K562 cells treated with interferon alpha (INFalpha) and the demethylating agent 5-AZA-CdR, and observe the synergetic antitumor effect of Xaf1 inducer and (-)-epigallocatechin-3-gallate (EGCG).
  64. doi An initial assessment of the consumer demand roundtable: Results and promise
    Dianne C Barker
    Barker Bi Coastal Health Consultants, Inc, Calabasas, California 91302, USA
    Am J Prev Med 38:S437-46. 2010
    An initial assessment of the National Tobacco Cessation Collaborative's (NTCC) 2005-2007 Consumer Demand Roundtable (CDR) was conducted in 2008 to assess the results and products of CDR, and to offer recommendations to guide ongoing NTCC ..
  65. ncbi Mechanism of allergic cross-reactions--III. cDNA cloning and variable-region sequence analysis of two IgE antibodies specific for trinitrophenyl
    H Kofler
    Department of Dermatology, University of Innsbruck, Austria
    Mol Immunol 29:161-6. 1992
    ..Both antibodies exhibited considerable conservation of complementarity determining region (CDR) sequences, which will facilitate template-based computer modeling of the three-dimensional structures of complexes ..
  66. ncbi Design and expression of soluble CTLA-4 variable domain as a scaffold for the display of functional polypeptides
    S D Nuttall
    CRC for Diagnostic Technologies and CSIRO Molecular Science, Parkville, Victoria, Australia
    Proteins 36:217-27. 1999
    ..First, to test whether the CTLA-4 CDR-like loops were permissive to loop replacement/insertion we substituted either the CDR1 or CDR3 loop with ..
  67. ncbi 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia
    M Koshy
    University of Illinois at Chicago, Chicago, IL, USA
    Blood 96:2379-84. 2000
    ..For patients with no HbF elevation after HU treatment, augmentation of HbF levels by 5-aza-2'-deoxycytidine (5-aza-CdR, decitabine) could serve as an alternate mode of treatment...
  68. ncbi Characterization of neutralization specificities of outer capsid spike protein VP4 of selected murine, lapine, and human rotavirus strains
    Yasutaka Hoshino
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
    Virology 299:64-71. 2002
    ..VP4 of murine rotavirus strains EW (P?[16],G3) and EHP (P?[20],G3) and lapine rotavirus strains Ala (P?[14],G3), C11 (P?[14],G3), and R2 (P?[14],G3) as well as human rotavirus strains PA169 (P?[14],G6) and HAL1166 (P?[14],G8) were ..
  69. ncbi Immobilized metal-ion affinity chromatography of recombinant Fab protein OPG C11 in the presence of EDTA-Mg(II)
    Hui Xiang
    J Chromatogr A 978:153-64. 2002
    ..In this study, by using His6-tagged protein Fab OPG C11 from Escherichia coli fermentation as a model, we found that the presence of low concentrations of EDTA-Mg2+ in ..
  70. pmc The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats
    Sarah W Zangen
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Int J Exp Diabetes Res 3:247-55. 2002
    ..defense mechanism in diabetes-induced anomalies was studied in the Cohen diabetes-sensitive (CDs) and -resistant (CDr) rats, a genetic model of nutritionally induced type 2 diabetes mellitus. Embryos, 12...
  71. pmc The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5
    Michael B Zwick
    Department of Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 78:3155-61. 2004
    ..at the base of the unusually long (22-residue) third complementarity-determining region of the heavy chain (CDR H3) but not the apex...
  72. ncbi Expression of CYP4F12 in gastrointestinal and urogenital epithelia
    Katarina Stark
    Department of Pharmaceutical Biosciences, Division of Biochemical Pharmacology, Uppsala University, Uppsala, Sweden
    Basic Clin Pharmacol Toxicol 94:177-83. 2004
    ..Arachidonic acid (20:4n-6) was hydroxylated at C18 and laurate at C11, but significant amounts of metabolites of 18:2n-6, 20:3n-9, 20:5n-3, 22:5n-6, and some prostaglandins could not be ..
  73. ncbi [Effect of 5-aza-2'-deoxycytidine on cell of high-risk patients with myelodysplastic syndrome in vitro]
    Hong Yan Tong
    Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 12:467-71. 2004
    To investigate the effect of 5-aza-2'-deoxycytidine (5-Aza-CdR) on cell of high-risk patients with myelodysplastic syndrome (MDS) in vitro, the growth inhibition of MUTZ-1 cell induced by 5-Aza-CdR was detected by MTT method; apoptosis ..
  74. ncbi Cyclic tetrasaccharide-synthesizing enzymes from Arthrobacter globiformis A19
    Kazuhisa Mukai
    Amase Institute, Hayashibara Biochemical Laboratories, Inc, 7 7 Amase minami machi, Okayama 700 0834, Japan
    Biosci Biotechnol Biochem 68:2529-40. 2004
    ..globiformis were similar to those of enzymes from Bacillus globisporus C11 and N75. Arthrobacter 6GT had a smaller molecular mass of 108 kDa and a higher optimum pH of 8...
  75. ncbi A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function
    Robert L Schelonka
    Department of Pediatrics, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 175:6624-32. 2005
    ..Bone marrow IgM+IgD+ B cells express a CDR-H3 repertoire similar in length and amino acid composition to the DFL16...
  76. ncbi Human monoclonal antibodies from transgenic mice
    N Lonberg
    Medarex, 521 Cottonwood Drive, Milpitas, CA 95035, USA
    Handb Exp Pharmacol . 2008
    ..the epidermal growth factor receptor, transgenic mice expressing human antibody repertoires join chimerization, CDR grafting, and phage display technologies, as a commercially validated antibody drug discovery platform...
  77. pmc Synthetic antibodies for specific recognition and crystallization of structured RNA
    Jing Dong Ye
    Department of Chemistry, Howard Hughes Medical Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:82-7. 2008
    ..reveals that the Fab achieves specific RNA binding on a shallow surface with complementarity-determining region (CDR) sequence diversity, length variability, and main-chain conformational plasticity...
  78. pmc Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway
    Min Jae Lee
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 105:100-5. 2008
    ..explore a model of heterovalent interaction to the N-recognin family, we synthesized the small-molecule compound RF-C11, which bears two heterovalent ligands designed to target N-recognins, together with control molecules with two ..
  79. doi Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve
    Anthony F Fotenos
    Division of Biology and Biomedical Sciences, Washington University Medical School, St Louis, Missouri, USA
    Arch Neurol 65:113-20. 2008
    ..To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD)...
  80. doi A common idiotype in IgE and its relation to recognition of the grass pollen allergen Phl p 2
    Helena Persson
    Department of Immunotechnology, Lund University, BMC D13, SE 221 84 Lund, Sweden
    Mol Immunol 45:2715-20. 2008
    ..motifs (idiotypes), such as IGHV4-31 germline gene origin and heavy chain complementarity-determining region (CDR) 3 length and sequence. They also combined with highly related light chain sequences...
  81. ncbi Photodegradation of crude oil: liquid injection and headspace solid-phase microextraction for crude oil analysis by gas chromatography with mass spectrometer detector
    Maurizio D'Auria
    Dipartimento di Chimica, Universita degli Studi della Basilicata, Via N Sauro 85, 85100 Potenza, Italy
    J Chromatogr Sci 46:339-44. 2008
    ..A decrease in the relative amount of the C8-C10 fractions is observed, while C11-C15 fractions increase...
  82. doi Bacteriocin-producing Lactobacillus strains isolated from poto poto, a Congolese fermented maize product, and genetic fingerprinting of their plantaricin operons
    Nabil Ben Omar
    Departamento de Ciencias de la Salud, Area de Microbiologia, Facultad de Ciencias Experimentales, Edif B 3, Universidad de Jaen, Campus Las Lagunillas s n, 23071 Jaen, Spain
    Int J Food Microbiol 127:18-25. 2008
    ..5%, and could be divided in two subgroups (G1-1, G1-2) each with several branches, plus the L. plantarum isolate C11. Group G2 contained 8 isolates with a similarity coefficient > 86%, with two main branches...
  83. doi Possible involvement of activation of P53/P21 and demethylation of RUNX 3 in the cytotoxicity against Lovo cells induced by 5-Aza-2'-deoxycytidine
    Tao Deng
    Department of Gastroenterology, Renmin Hospital of Wuhan University, No 238 Jiefang Road, Wuhan, Hubei 430064, China
    Life Sci 84:311-20. 2009
    In our model, we aimed to explore the cytotoxicity of 5-Aza-2'-deoxycytidine (5-Aza-CdR) against the colorectal cell line, Lovo, and further characterize the possible mechanisms.
  84. ncbi [Effect of reconstruction parameters on a calculation of left ventricular volumes by OS-EM reconstruction algorithm including various image corrections]
    Yuuya Nakamura
    Graduate School of Health Sciences, Kumamoto University, Japan
    Nihon Hoshasen Gijutsu Gakkai Zasshi 65:931-7. 2009
    ..reconstruction parameters when using the ordered subsets expectation maximization (OS-EM) method and 3D OS-EM (Astonish) method including the collimator distance response (CDR) recovery (RC) for myocardial perfusion SPECT study.
  85. doi A germline knowledge based computational approach for determining antibody complementarity determining regions
    Shanrong Zhao
    R and D Informatics, Centocor Discovery Research, San Diego, CA 92121, USA
    Mol Immunol 47:694-700. 2010
    ..Another feature of the algorithm is that it is CDR definition independent, and can be easily extended to other CDR definitions besides the most widely used Kabat, ..
  86. ncbi [Effect of 5-Aza-CdR on expression and methylation of E-cadherin gene in human colon carcinoma cells]
    Jian Zhen Ren
    Department of Gastroenterology, the 2nd Xiangya Hospital, Central Southern University, Changsha, Hunan 410011, People s Republic of China
    Chin J Cancer 29:38-42. 2010
    ....
  87. doi UGT2B7_-161C>T polymorphism is associated with lamotrigine concentration-to-dose ratio in a multivariate study
    María Blanca Sánchez
    Service of Clinical Pharmacology, Marques de Valdecilla University Hospital, University of Cantabria School of Medicine, Santander, Spain
    Ther Drug Monit 32:177-84. 2010
    ..UGT2B7_372A>G polymorphisms contribute to the intersubject variability in LTG concentration-to-dose ratio (LTG-CDR) in epileptic patients...
  88. doi NMR structural studies on the covalent DNA binding of a pyrrolobenzodiazepine-naphthalimide conjugate
    Michael Rettig
    Institute of Biochemistry, Ernst Moritz Arndt Universitat Greifswald, Felix Hausdorff Str 4, D 17487, Greifswald, Germany
    Org Biomol Chem 8:3179-87. 2010
    ..covalently linked within the minor groove to a guanine with an S stereochemistry at its covalent linkage site at C11 and a 5'-orientation of its A-ring carrying the linker with the naphthalimide ligand...
  89. doi Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes
    Ronit Barkalifa
    Faculty of Health Sciences, Ben Gurion University, Barzilai Medical Center Campus, Ashkelon, Israel
    Physiol Genomics 42:445-55. 2010
    ..We used an F2 population resulting from a cross between Cohen Diabetic susceptible (CDs) and resistant (CDr) and consisting of 132 males and 159 females to detect relevant QTLs by linkage and cosegregation analyses...
  90. pmc Antibodies as a model system for comparative model refinement
    Benjamin D Sellers
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158 2517, USA
    Proteins 78:2490-505. 2010
    ..e., the portion other than the complementarity determining region, CDR, loops) retains native backbone conformation, whereas the CDR loops are predicted using a combination of knowledge-..
  91. doi The testosterone binding mechanism of an antibody derived from a naïve human scFv library
    Merja H Niemi
    Department of Chemistry, University of Eastern Finland, P O Box 111, FIN 80101 Joensuu, Finland
    J Mol Recognit 24:209-19. 2011
    ..In addition to the interactions with framework residues only CDR-L3 and CDR-H3 loops interact with testosterone and the heavy chain forms the majority of the contacts with the ..
  92. pmc The Structured Interview & Scoring Tool-Massachusetts Alzheimer's Disease Research Center (SIST-M): development, reliability, and cross-sectional validation of a brief structured clinical dementia rating interview
    Olivia I Okereke
    Department of Psychiatry, Gerontology Research Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Neurol 68:343-50. 2011
    The Clinical Dementia Rating (CDR) and CDR Sum-of-Boxes can be used to grade mild but clinically important cognitive symptoms of Alzheimer disease. However, sensitive clinical interview formats are lengthy.
  93. doi Suitability of the Clinical Dementia Rating-Sum of Boxes as a single primary endpoint for Alzheimer's disease trials
    Nicola Coley
    University of Toulouse III, France
    Alzheimers Dement 7:602-610.e2. 2011
    ..We evaluated the psychometric properties of the Clinical Dementia Rating-Sum of Boxes (CDR-SB) to assess its suitability as a single primary endpoint as an alternative to the traditional co-primary approach.
  94. doi Treatment with Huperzine A improves cognition in vascular dementia patients
    Zhi Qiang Xu
    Department of Neurology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Daping, Chongqing, China
    Cell Biochem Biophys 62:55-8. 2012
    ..1-mg bid) (n = 39) for 12 consecutive weeks. The mini-mental state examination (MMSE), clinical dementia rating (CDR), and activities of daily living (ADL) scores were used for the assessment of cognition...
  95. pmc Clinical characteristics of a nationwide hospital-based registry of mild-to-moderate Alzheimer's disease patients in Korea: a CREDOS (Clinical Research Center for Dementia of South Korea) study
    Hee Kyung Park
    Department of Neurology, Inje University Ilsan Paik Hospital, Goyang, Korea
    J Korean Med Sci 26:1219-26. 2011
    ..2 and the mean sum of box scores of Clinical Dementia Rating (CDR-SB) 5.1...
  96. doi Phase II study on combination therapy with CHOP-Zenapax for HTLV-I associated adult T-cell leukaemia/lymphoma (ATLL)
    M Mansour Ceesay
    Department of Haematological Medicine, King s College Hospital NHS Foundation Trust and King s College London, London, UK
    Leuk Res 36:857-61. 2012
    ..Daclizumab (Zenapax(®)) is a humanised murine anti-CD25 monoclonal antibody, which contains 10% murine CDR sequences...
  97. doi Total synthesis of (-)-dendrobine
    Lukas M Kreis
    Laboratorium fur Organische Chemie, ETH Zurich, Switzerland
    Angew Chem Int Ed Engl 51:3436-9. 2012
    ..The amine is the initiator of the cascade and provides an efficient method for installing the stereocenters at C11 and C3...
  98. pmc Structural brain alterations before mild cognitive impairment in ADNI: validation of volume loss in a predefined antero-temporal region
    Charles D Smith
    Department of Neurology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536 0098, USA
    J Alzheimers Dis 31:S49-58. 2012
    ..Disease Neuroimaging Initiative (ADNI) who subsequently developed cognitive complaints as reflected in a CDR memory box score of 0...
  99. doi The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments
    Ian Paterson
    University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Org Biomol Chem 10:5861-72. 2012
    ..allylation to install the C9 hydroxyl, and a 1,4-syn boron aldol/directed reduction sequence to establish the C11 and C13 stereocentres...
  100. doi Temperature and cell-type dependency of sulfide effects on mitochondrial respiration
    Michael Groeger
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum Ulm, Germany
    Shock 38:367-74. 2012
    ..the mitochondrial sulfide oxidation by the sulfide-ubiquinone oxidoreductase in macrophage-derived cell lines (AMJ2-C11 and RAW 264.7)...
  101. ncbi [Perioperative disorders of mental functions]
    Dinko Tonkovic
    School of Medicine, University of Zagreb, Zagreb, Croatia
    Acta Med Croatica 66:73-9. 2012
    ..Among the most commonly used are the Confusion Assessment Method (CAM-ICU) and Clinical Dementia Rating (CDR) test...

Research Grants70

  1. Radioimmunotherapy: An Anti-Neoplastic Strategy
    Andres Forero; Fiscal Year: 2006
    ..3. The immunogenicity of mCC49, the long half-life (50h) and the projected even longer half-life of a chimeric or CDR-grafted version led to studies directed at humanization with deletion of various parts in search of a construct ..
  2. Role of IG CDR-H3 in Responses to HIV Vaccines
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2013
    ..the norm in that each of their antigen binding sites contain a long, H chain complementarity determining region 3 (CDR-H3) that lacks tyrosine and includes patches of hydrophobic and charged amino acids...
  3. Andrew D Weinberg; Fiscal Year: 2014
    ..humanization of the anti-OX40 antibody after insertion of the identical murine antibody's variable region CDR sequences into human IgG frameworks, assessment of OX40 binding and bioactivity in vitro, and development of a ..
  4. A novel pre-defined CDR library for selection of affinity reagents
    Michael P Weiner; Fiscal Year: 2013
    ..We have termed this new library-type as a 'pre-defined CDR'(PDC) library...
  5. Mark J Young; Fiscal Year: 2014
    ..2) Antibody CDR dimers (Specific aim 2)...
  6. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David R Clemmons; Fiscal Year: 2010
    ..structure of the antibody will be undertaken to determine those residues that are within 10 angstroms of the CDR antigen binding site. These residues will also be modified to reduce their interaction with the binding domain...
  7. Mucosal Immune Ontogeny and Intestinal Microbiota in Infants
    Edward N Janoff; Fiscal Year: 2010
    ..In B cells, immunoglobulin genes, particularly the 3 hypervariable complementarity determining regions (CDR) of heavy chains (VH), show the greatest diversity and contribute most to antigen binding5...
  8. Jason T Kimata; Fiscal Year: 2015
    ..data indicate that targeting single-chain Fv (scFv) or the heavy chain third complementarity-determining region (CDR H3) of some anti-HIV-1 Env MAbs to lipid rafts with a glycosyl-phosphatidyl-inositol (GPI)-anchor enhances their ..
  9. Immunoglobulin CDR-H3 and neutralizing antibodies to HIV
    Harry Schroeder; Fiscal Year: 2009
    ..that each of their antigen binding sites contain a long, hydrophobic H chain complementarity determining region 3 (CDR-H3)...
  10. PROTEOLYTIC ANTIBODIES FOR TREATMENT OF PSORIASIS
    ROBERT BALINT; Fiscal Year: 2009
    ..repertoire contain canonical serine protease-like catalytic triads in their complementarity-determining regions (CDR), and some have detectable peptidolytic activity...
  11. The role of T cell repertoire selection in the NOD mouse model of MOG-induced EAE
    Anthony Quinn; Fiscal Year: 2007
    ..the pocket of the I-Ag7 molecule, and others that interact directly with the complementarity determining regions (CDR) of the TCR variable regions, we will resolve the fine antigenic specificity of the dominant MOG clonotypes in each ..
  12. Longitudinal study of membrane lipids: pre-clinical Alzheimer's biomarkers
    Michelle M Mielke; Fiscal Year: 2010
    ..and our preliminary data, suggest these lipids are altered in blood, CSF and brain in the earliest stages of AD (CDR 0.5), and vary by AD severity...
  13. ANTIBODY DISPLAY OF PEPTIDE ANTAGONISTS OF IL-1 RECEPTOR
    Jeffry Watkins; Fiscal Year: 1999
    ..Display of the peptides within the third complementarity-determining region (CDR) of the heavy chain will be optimized by synthesis of expression libraries in which the CDR positions of the ..
  14. Suzanne Craft; Fiscal Year: 2016
    ..Two-hundred and forty participants with aMCI (Petersen criteria, Clinical Dementia Rating/CDR 0.5) or mild AD (NINDS-ADRDA criteria, CDR 0.5-1.0, Mini-mental State Exam20) will be enrolled...
  15. GROVER CLEVELAND GILMORE; Fiscal Year: 2015
    ..Patients will be stratified by AD severity (CDR mild or moderate) and cataract severity (LOCS 1-2 or 3-4) prior to being randomized...
  16. Yvette I Sheline; Fiscal Year: 2015
    ..placebo controlled trial of 54 cognitively normal participants, age 65- 80, (Clinical Dementia Rating scale, [CDR] = 0) recruited from the Washington University ADRC...
  17. Conversational Engagement as a Means to Delay Alzheimer's Disease Onset
    HIROKO HAYAMA DODGE; Fiscal Year: 2012
    ..Aim 2. Among those interviewed in Aim 1, we will recruit 80 subjects with Clinical Dementia Rating Scale (CDR) = 0 and 80 subjects with CDR = 0.5 from the lower end of the social engagement frequencies...
  18. Mark I Greene; Fiscal Year: 2015
    ..We will use a fragment of human HER2 that is structurally like a CDR and link it to human Fc fragments...
  19. Functional Decline in Three Dementia Types
    WALTER ANTHONY KUKULL; Fiscal Year: 2012
    ..of probable AD, probable VaD, or DLB);2) age 60+ years (visit 1);3) Clinical Dementia Rating-Sum of Boxes (CDR-SOB) score <16 (visit 1);and 4) time between successive visits restricted to 0.5-1.5 years...
  20. Age related Cognitive Loss in Mumbai, India
    Dushyant P Purohit; Fiscal Year: 2010
    ..who come to autopsy and are free of cognitive impairment (based on a postmortem Clinical Dementia Rating Score or CDR of 0)...
  21. Sterling C Johnson; Fiscal Year: 2016
    ..may shed light on explanatory mechanisms of our previously observed findings by measuring amyloid burden using [C11]PiB, regional cerebral metabolic rate of glucose (rCMRglu) using [F18]fluoro-deoxyglucose (FDG) positron emission ..
  22. Measuring change in Alzheimer's disease dysfunction more precisely with IRT
    Steve Balsis; Fiscal Year: 2012
    ..To do this we will extend our preliminary cross-sectional findings for this measure, the MMSE, and the CDR, to examine data longitudinally in Baylor College of Medicine's Alzheimer's Disease and Memory Disorder ..
  23. TARGETING THE B-CELL RECPTOR COMPLEX AND DOWNSTREATM KINASES
    Sydney Welt; Fiscal Year: 2010
    ..Previous strategies to target the BCRC molecules in B-cell malignancies have focused on the unique CDR sequences specific for each monoclonal tumor...
  24. Structure/Function of Steroid Transforming AKR's
    Trevor M Penning; Fiscal Year: 2011
    ..The 5[unreadable],3a-configuration common to all bile-acids is likely formed when AKR1D1 couples to AKR1C4. Whether these two genes from the AKR superfamily are responsible for bile acid formation remains to be formally ..
  25. Trevor M Penning; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Human Aldo-Keto Reductases (AKR1A1, AKR1C1-AKR1C4) catalyze the activation of polycyclic aromatic hydrocarbon (PAH) trans-dihydrodiols to yield catechols which autooxidize to electrophilic and redox-..
  26. George Zubal; Fiscal Year: 2014
    ..to develop a software package to automatically evaluate a subject's beta amyloid PET scan (using either C11-PIB, F18-florbetaben, or F18-florbetapir, F18-flutemetamol) by normalizing the subject's scan, masking away ..
  27. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2012
    ..It is our hypothesis that failure to properly regulate one specific part of the antibody, CDR-H3, in susceptible individuals facilitates production of anti-DNA antibodies and triggers disease...
  28. ERIC M VERDIN; Fiscal Year: 2014
    ..We also found that the inhibitor of DNA methylation, 5-aza-2'deoxycytidine (aza-CdR), synergizes with NF-B activators to reactivate latent HIV...
  29. DELIRIUM IN PERSONS WITH DEMENTIA
    Donna Fick; Fiscal Year: 2007
    ..of Daily Living Scale (IADL), Charlson Co-morbidity Index, Apache II, the Clinical Dementia Rating scale (CDR), a family semi-structured interview form, and a Modified Blessed Scale...
  30. David A Scheinberg; Fiscal Year: 2016
    Over the last 15 years on this grant, we have established that biologically active, CDR grafted humanized IgG, novel radioconjugates and toxin conjugates, many based on the anti-CD33 Ig HuM195, can be constructed, characterized, and ..
  31. Anaerobic shock as a novel treatment for tuberculosis
    Xilin Zhao; Fiscal Year: 2010
    ..of multiple drug- resistant (MDR) infections and the emergence of extensively/completely drug-resistant (XDR/CDR) tubercle bacilli are making currently chemotherapies less and less effective...
  32. Kate Rittenhouse-Olson; Fiscal Year: 2014
    ..Humanization will precede using modified CDR grafting onto the human antibody molecule variable sequence found to be most like the JAA-F11 mouse sequence in ..
  33. MECHANISMS OF DE NOVO METHYLATION IN CANCER
    Peter A Jones; Fiscal Year: 2013
    ..This research has led to the recent approval by the FDA of two DNA demethylating agents (5-aza-CR and 5-aza-CdR) for the treatment of myeloid dysplastic syndrome...
  34. MOLECULAR ANALYSIS OF CD8, MHC CLASS I INTERACTION
    Paula B Kavathas; Fiscal Year: 2012
    ..We identified critical residues on the CDR-like loops of the immunoglobulin-like domain CD8b protein required for binding to pMHC1 as well as mutants that led ..
  35. Epigenetic alterations underlying tumorigenic potential of Glioblastoma Cells
    Theresa K Kelly; Fiscal Year: 2012
    ..with this information, in the independent phase, I will treat GBM cells with the DNA demethylating agent 5-Aza-CdR and measure the ability of demethylation to restore normal gene expression patterns and resolve aberrant chromatin ..
  36. New Methods for the Expedited Synthesis of C11 and F18 PET Tracers
    Salvatore D Lepore; Fiscal Year: 2013
    ....
  37. Jeffrey J Gray; Fiscal Year: 2015
    ..work has isolated the most critical challenges: most of the antibodies in the human repertoire have hypervariable CDR H3 loops longer than that which is predictable using current loop methods;backbone conformational uncertainty and ..
  38. Rachel P Berger; Fiscal Year: 2014
    ..We have also derived a sensitive and specific clinical decision rule (CDR) for predicting ICN using easily measured clinical and laboratory variables...
  39. Molecular studies of lipid presentation and T cell recognition of CD1c
    ERIN JUNE ADAMS; Fiscal Year: 2013
    ..and/or cytotoxicity) and the sequence of their TCRs, specifically to determine whether there are motifs in the CDR loops that are used in this recognition process...
  40. Sylvie Breton; Fiscal Year: 2016
    ..A-ICs isolated by FACS from B1-EGFP mice, the C11 intercalated cell line, and microdissected OMCDs will be examined using complementary imaging, biochemical and ..
  41. Characterization of Pathogenic T cells in Alopecia Areata
    EMANUAL M MAVERAKIS; Fiscal Year: 2012
    ..T cells can be identified, characterized and followed longitudinally in patients with alopecia areata by combining CDR-3 length repertoire analysis with magnetic sorting and flow cytometry...
  42. Developing a PET biomarker to predict response in treatment-resistant depression
    PATRICK J MC GRATH; Fiscal Year: 2010
    ..in the brains of depressed patients with MDD compared to controls, using positron emission tomography (PET) with a C11 labeled monoamine oxidase inhibitor (MAOI), has provided an unparalleled opportunity to address these challenges (..
  43. Daniel Starczynowski; Fiscal Year: 2016
    ..We recently identified miR-146a, which is near the distal CDR, to be significantly reduced in del(5q) MDS patients...
  44. AAC Rehabilitation for Conversation in Dementia
    Melanie Fried Oken; Fiscal Year: 2006
    ..Participants are 60 adults with moderate dementia as defined by a CDR score of 2, MMSE between 5-15, and enrollment in the Oregon Alzheimer's Disease Center...
  45. BEHZAD MOSLEHI; Fiscal Year: 2015
    ..at the Stanford Medical School, Professor Mark Cutkosky's group at the Stanford Center for Design Research (CDR) and HeartVista, for clinical imaging platform software integration...
  46. Mary Clyde Pierce; Fiscal Year: 2015
    ..b>CDR modeling will be performed using a binary recursive partitioning algorithm...
  47. Janey L Wiggs; Fiscal Year: 2016
    ..primary focus of identifying genes contributing to the POAG-related quantitative endophenotype, cup-to-disc ratio (CDR)...
  48. Function of the Nuclear Receptor LRH-1
    David D Moore; Fiscal Year: 2010
    ..We have found that unusual phosphatidylcholine (PC) species with two C11:0 (diundecanoyl;DUPC) or two C12:0 (dilauroyl;DLPC) fatty acid side chains are potent activators of LRH-1 ..
  49. Lei Liu; Fiscal Year: 2015
    ..methods will be applied to empirical case studies using three real-world databases: Clinical Data Repository (CDR) at the University of Virginia (UVA) Health System, Medical Expenditure Panel Survey (MEPS), and the SEER- Medicare ..
  50. HIV-1 Neutralizing Antibody Binding to Viral Membrane Mimics
    Stefan Zauscher; Fiscal Year: 2013
    ..2) CDR H3 loops on 2F5 and 4E10 embed selectively into mobile domains on HIV-1 Env mimetic membranes...
  51. Targeted Therapy of B-cell Malignancies
    David Goldenberg; Fiscal Year: 2009
    ..the most promising from our own published studies and those of others, and because we now have access to humanized (CDR-grafted) forms of these antibodies...
  52. Electrophysiological studies of synapse formation by regenerating CST axons
    Eric Frank; Fiscal Year: 2012
    ..A major target of CST axons in mice are Clarke's column neurons, located in the C11 - L2 segments of the spinal cord, in close proximity to the CST...
  53. Lawrence J Stern; Fiscal Year: 2016
    ..We will characterize interactions between TCR alpha subunit residues and beta subunit CDR loops, and vice versa, to determine how these shape MHC-TCR interaction...
  54. Storage and Distribution of Clinical Agents
    Young Kim; Fiscal Year: 2010
    ..requires an agent supply for an NCI study, the clinical trial site submits an order called a Clinical Drug Request (CDR)...
  55. JEFFREY MURRAY BURNS; Fiscal Year: 2016
    ..of Kansas Alzheimer's Disease Center (KU ADC;P30AG035982) will screen 400 sedentary, cognitively normal (CDR 0) individuals age 65 and older with Florbetapir PET imaging to enroll 100 preclinical AD participants into the ..
  56. Storage and Distribution of Clinical Agents
    Young Kim; Fiscal Year: 2009
    ..requires an agent supply for an NCI study, the clinical trial site submits an order called a Clinical Drug Request (CDR)...
  57. Brian M Baker; Fiscal Year: 2015
    ..bases for TCR specificity and cross-reactivity, focusing on three closely related topics: the dynamics of TCR CDR loops, the mechanisms by which TCRs engage pMHC, and the distribution of binding energy within TCR- pMHC interfaces...
  58. Storage and Distribution of Clinical Agents
    Young Kim; Fiscal Year: 2011
    ..requires an agent supply for an NCI study, the clinical trial site submits an order called a Clinical Drug Request (CDR)...
  59. Cocaine degradation: Improving antibody efficacy
    KATHLEEN MCKENZIE; Fiscal Year: 2006
    ..The first involves affinity maturation by complementarity determining region (CDR) walking based on unpublished crystal structure results from the Wilson and Janda laboratories, while the second ..
  60. ENGINEERING OF ANTIDIGOXIN ANTIBODY COMBINING SITES
    MICHAEL MARGOLIES; Fiscal Year: 1999
    ..of mutagenesis, employing, as appropriate, random mutagenesis of entire V regions, site-directed mutagenesis, CDR loop lengthening, and combinatorial mutagenesis involving different CDRs and both chains...
  61. Conformationally-Constrained PA Anthrax Vaccine
    Maurizio Zanetti; Fiscal Year: 2005
    ..crystallography studies characterized this loop as having the structure of the complementarity-determining region (CDR) of an immunoglobulin (Ig)...
  62. PATHOGENESIS AND PREVENTION OF IDDM
    Hugh McDevitt; Fiscal Year: 2002
    ..These T cell receptor V beta and V alpha sequences have detectable shared CDR 3 sequence motifs, suggesting an antigen specific T cell response...
  63. ROLE OF THE GALLBLADDER IN PATHOGENESIS OF GALLSTONES
    LESTER WILLIAMS; Fiscal Year: 1991
    ..Since (1) GB stasis with increased cystic duct resistance (CDR) occurs early after initiating a lithogenic diet before crystals occur; (2) since increased GB prostaglandin (PG) ..
  64. Mechanisms of Cutaneous Drug Reactions
    CRAIG SVENSSON; Fiscal Year: 2004
    Cutaneous drug reactions (CDR) are among the most frequent adverse medical events. Recent studies suggest that between 30 and 45 percent of all adverse drug reactions involve the skin...
  65. Engineered antibody for reducing localized fibrotic scarring
    Andrzej Fertala; Fiscal Year: 2012
    ..will serve as a catalyst to develop their fully humanized versions through complementarily determining regions (CDR) grafting...
  66. INHIBITION OF 3A HSD BY ANTI-INFLAMMATORY DRUGS
    TREVOR PENNING; Fiscal Year: 1991
    ..These studies may provide information for a rational approach to the design of superior antiinflammatory drugs...
  67. CLONOTYPIC PCR FOR MINIMAL RESIDUAL DISEASE IN LYMPHOMA
    Ariela Noy; Fiscal Year: 2002
    ..The sequences of greatest diversity comprising complementarity region-III (CDR-III) or the V-beta counterpart provide excellent targets for clone specific MRD probes...
  68. MOLECULAR STUDIES OF A KEY BILE ACID METABOLIZING ENZYME
    Andrew Stolz; Fiscal Year: 1993
    ..In addition to bile acid transport, 3 alpha HSD is required for bile acid synthesis from cholesterol...
  69. Marino De Leon; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Loma Linda University Center for Health Disparities Research (LLU CHDR) was established by an EXPORT award from the NCMHD to develop new infrastructure for research in health disparities at LLU ..
  70. COMBINED RADIOIMMUNOTHERAPY & CHEMOTHERAPY--COLON CANCER
    Malik Juweid; Fiscal Year: 1999
    ..We intend, therefore, to conduct a phase-I trial of combined 5-FU-LV and RAIT with a CDR-grafted (humanized) 131I-MN-14 (hMN-14) second-generation, high affinity anti-CEA MAb...