Genomes and Genes
Gene Symbol: AKR1C1
Description: aldo-keto reductase family 1 member C1
Alias: 2-ALPHA-HSD, 20-ALPHA-HSD, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1 member C1, 20 alpha-hydroxysteroid dehydrogenase, aldo-keto reductase C, chlordecone reductase homolog HAKRC, dihydrodiol dehydrogenase 1, dihydrodiol dehydrogenase 1/2, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase isoform DD1, hepatic dihydrodiol dehydrogenase, high-affinity hepatic bile acid-binding protein, indanol dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, type II 3-alpha-hydroxysteroid dehydrogenase
Publications250 found, 100 shown here
- cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene familyA Stolz
Division of Gastrointestinal and Liver Diseases, University of Southern California School of Medicine, Los Angeles 90033
J Biol Chem 268:10448-57. 1993..identified one isoform of dihydrodiol dehydrogenase activity that expresses high affinity bile acid binding (HBAB) with minimal 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) activity for bile acids...
- Characterization of a human 20alpha-hydroxysteroid dehydrogenaseY Zhang
Oncology and Molecular Endocrinology Research Center, CHUQ PCHUL and Laval University, Quebec, Quebec G1V 4G2, Canada
J Mol Endocrinol 25:221-8. 2000..The present study clearly indicates that the genuine human 20alpha-HSD belongs to the aldoketo reductase family, like the 20alpha-HSDs from other species...
- Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolutionV Nahoum
Oncology and Molecular Endocrinology Research Center, Laval University Medical Center, Quebec, Quebec G1V 4G2, Canada
J Biol Chem 276:42091-8. 2001....
- Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroidsJean Francois Couture
Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL 2705 boul Laurier, Ste Foy, QC, Canada G1V 4G2
J Mol Biol 331:593-604. 2003Human 20alpha-hydroxysteroid dehydrogenase (h20alpha-HSD; AKR1C1) catalyzes the transformation of progesterone (Prog) into 20alpha-hydroxy-progesterone (20alpha-OHProg)...
- [Non-tuberculous mycobacteriosis. What has been coming out]Akira Kajiki
Department of Respiratory Medicine, National Hospital Organization Ohmuta National Hospital, Fukuoka, Japan
Kekkaku 86:113-25. 2011..of non-tuberculous mycobacteriosis is relatively easy, because of recent technological advances (HRCT, MGIT, PCR, DDH etc). Although many reports of this disease have been published, there are many problems to resolve...
- Inhibition of induction of 20 alpha-hydroxysteroid dehydrogenase activity in rat corpora lutea in vitro by the progesterone antagonist RU486J T Uilenbroek
Department of Endocrinology and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
Life Sci 50:1173-8. 1992..However, since these effects in vitro can only be obtained with high concentrations of RU486, it is unlikely that this antiluteolytic effect plays a role after injection of RU486 in vivo...
- Dual regulation of luteal progesterone production by androstenedione during spontaneous and RU486-induced luteolysis in pregnant ratsC M Telleria
Laboratorio de Reproduccion y Lactancia, CRICYT CONICET, Mendoza, Argentina
J Steroid Biochem Mol Biol 55:385-93. 1995....
- Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormonesT M Penning
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
Biochem J 351:67-77. 2000..1 3alpha-HSD (AKR1C4), type 2 3alpha(17beta)-HSD (AKR1C3), type 3 3alpha-HSD (AKR1C2) and 20alpha(3alpha)-HSD (AKR1C1), and share at least 84% amino acid sequence identity...
- Expression, purification and characterization of the rat luteal 20 alpha-hydroxysteroid dehydrogenaseJ Mao
Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60612 7342, USA
Endocrinology 138:182-90. 1997The enzyme, rat ovarian 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD), plays a central role in luteolysis and parturition...
- Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosisN Hevir
Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Chem Biol Interact 191:217-26. 2011..The aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) are the major reductive 20α-HSDs, while the oxidative reaction is catalyzed by 17β-HSD type 2 (..
- Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteinsT M Penning
Department of Pharmacology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Mol Cell Endocrinol 215:63-72. 2004..They share 86% sequence identity and correspond to: AKR1C1 (20 alpha(3 alpha)-HSD); AKR1C2 (type 3 3 alpha-HSD and bile-acid binding protein); AKR1C3 (type 2 3 alpha-HSD and ..
- Peripheral neuropathy in transgenic diabetic mice: restoration of C-fiber function with human recombinant nerve growth factorK A Elias
Genentech, San Francisco, California 94080, USA
Diabetes 47:1637-42. 1998Mice (Ins.Dd1) with hypoinsulinemic diabetes were created by increased expression of syngeneic major histocompatibility complex (MHC) class I protein in pancreatic beta-cells...
- [Geographic distribution of Mycobacterium avium-intracellulare complex serovars isolated from patients in five cities of Japan]A Sato
Department of Bacteriology, Kobe Institute of Health, Hyogo, Japan
Kansenshogaku Zasshi 74:64-72. 2000..avium and M. intracellulare by DNA-DNA hybridization assay (DDH)...
- 3(20)alpha-hydroxysteroid dehydrogenase activity of monkey liver indanol dehydrogenaseA Hara
Department of Biochemistry, Gifu Pharmaceutical University
J Biochem 106:900-3. 1989Homogeneous indanol dehydrogenase from monkey liver catalyzed the reversible conversion of 3 alpha- or 20 alpha-hydroxy groups of several bile acids and 5 beta-pregnanes to the corresponding 3- or 20-ketosteroids...
- Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesteroneYu Higaki
Laboratory of Biochemistry, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585, Gifu, Japan
Chem Biol Interact 143:503-13. 2003..for the neuroactive steroids and their precursors among four human 3(20)alpha-hydroxysteroid dehydrogenases (AKR1C1-AKR1C4) suggests that AKR1C1 and AKR1C2 are involved in the catabolism and synthesis, respectively, of the ..
- Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroidStephan Steckelbroeck
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
Mol Pharmacol 66:1702-11. 2004..Homogeneous recombinant AKR1C1, AKR1C3, and AKR1C4 gave similar catalytic profiles to those observed with 5alpha-DHT...
- Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3N Beranič
Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Chem Biol Interact 191:227-33. 2011The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) are important 20-ketosteroid reductases in pre-receptor regulation of progesterone action...
- Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activityW R Lacy
Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030
Mol Endocrinol 7:58-66. 1993..up to 30% of the soluble proteins of the ovary, has been found to have 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD) activity...
- Associated risk factors in children who had late presentation of developmental dysplasia of the hipFreih Odeh Abu Hassan
Department of Orthopedics Surgery, Jordan University Hospital, P O Box 73 Jubaiha, Amman, 11941, Jordan
J Child Orthop 1:205-10. 2007The purpose of this study was to assess the role of clinical examination, associated risk factors and plain radiograph of the pelvis in children who had late presentation of DDH.
- [The importance of predicted risk factors in developmental hip dysplasia: an ultrasonographic screening program]Levent Karapinar
Department of Orthopedics and Traumatology 1 Ortopedi ve Travmatoloji Kliniği, Izmir SSK Training Hospital, 35380 Tepecik, Turkey
Acta Orthop Traumatol Turc 36:106-10. 2002To evaluate the role of the risk factors in the diagnosis of developmental hip dysplasia (DDH) by ultrasonographic screening.
- [Ultrasound screening for hip dysplasia in newborns and treatment with Frejka pillow]Hans Christian Blom
Tidsskr Nor Laegeforen 125:1998-2001. 2005The prevailing strategy concerning ultrasound screening for DDH in newborns in Norway does not intercept all who should be treated...
- Participation of intraluteal progesterone and prostaglandin F2 alpha in LH-induced luteolysis in pregnant ratC O Stocco
, CRICYT CONICET, Mendoza, Argentina
J Endocrinol 156:253-9. 1998..Thus, the early decline in 3 beta-HSD activity and the consequent fall in intraluteal P4 content, may trigger the synthesis of PGs and thereafter the increase in luteal 20 alpha-HSD activity to establish luteolysis...
- [Identification of mycobacteria by sequencing of rpoB gene and 16S rRNA]Yuko Kazumi
TB Information Division, Molecular Epidemiology and Genetic Identification, Mycobacterium Reference Center, Research Institute of Tuberculosis, JATA, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533 Japan
Kekkaku 81:551-8. 2006To classify a specific Mycobacterium among various mycobacteria utilizing sequencing of rpoB gene. To classify mycobacteria not identified by DNA-DNA hybridization (DDH) using sequencing of rpoB and 16S rRNA gene.
- The evaluation of hip muscles in patients treated with one-stage combined procedure for unilateral developmental dysplasia of the hip: part I: MRI evaluationHalil Yalçın Yüksel
Third Orthopaedics and Traumatology Clinic, Ankara Numune Educational and Research Hospital, Ankara, Turkey
J Pediatr Orthop 29:872-8. 2009To assess the status of hip flexor and extensor muscles with MRI in patients with unilateral developmental dysplasia of the hip (DDH) after walking age who were treated with one-stage combined procedure.
- Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activityN Wintergalen
Zentrum für Frauenheilkunde, Westfalische Wilhelms Universitat, Munster, Germany
Eur J Biochem 234:264-70. 1995..For this reason the aldo-keto reductase could be a key enzyme in the cascade of events leading to the regression of the corpus luteum in the rabbit...
- Anterolateral muscle sparing approach total hip arthroplasty: an anatomic and clinical studyXian Long Zhang
Department of Orthopaedics, Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
Chin Med J (Engl) 121:1358-63. 2008..In this study, a modified anterolateral muscle sparing approach was developed to optimize MIS-THA...
- Familial predisposition to developmental dysplasia of the hipDavid A Stevenson
Department of Pediatrics, University of Utah, Salt Lake City, UT 84132, USA
J Pediatr Orthop 29:463-6. 2009Developmental dysplasia of the hip (DDH) is a common birth defect and is thought to have genetic contributions to the phenotype. It is likely that DDH is genetically heterogeneous with environmental modifiers...
- Effect of calyculin-A, phosphatase inhibitor, on 20 alpha-hydroxysteroid dehydrogenase activity in rat luteal cell cultureK Yamanouchi
Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Japan
Endocr J 40:699-704. 1993..These results suggest that a CL-A sensitive phosphatase(s) may be involved in the action of PRL in suppressing the increase in 20 alpha-HSD activity in rat luteal cells...
- Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression arrayC Stocco
Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois
Endocrinology 142:4158-61. 2001....
- Characterization of the aldo-keto reductase 1C gene cluster on pig chromosome 10: possible associations with reproductive traitsDan J Nonneman
USDA ARS, US Meat Animal Research Center, Clay Center, Nebraska, 68933, USA
BMC Vet Res 2:28. 2006..Because of their location in the swine genome and their implication in reproductive physiology, this gene cluster was characterized and evaluated for effects on reproductive traits in swine...
- Possible role of transforming growth factor-beta as a mediator of luteotropic action of prolactin in rat luteal cell culturesS Matsuyama
Department of Veterinary Physiology, University of Tokyo, Japan
Endocrinology 127:1561-7. 1990..action in rats and enhances progesterone secretion by suppressing 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD) activity in the corpus luteum...
- Mechanoreceptor evaluation of hip joint capsule and ligamentum capitis femoris in developmental hip dysplasia: a preliminary studyHasan H Muratli
Third Orthopedics and Traumatology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
J Pediatr Orthop B 13:299-302. 2004..in the hip joint capsule and ligamentum capitis femoris (LCF) of patients with developmental dysplasia of the hip (DDH). We took capsule and LCF biopsies from 20 hips of 20 patients who were operated on because of DDH...
- Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signalingQing Ji
Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
Cancer Res 67:1361-9. 2007We previously reported the selective loss of AKR1C2 and AKR1C1 in prostate cancers compared with their expression in paired benign tissues...
- Proteomic analysis of secreted proteins of non-small cell lung cancerLing Jin Huang
Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P R China
Ai Zheng 25:1361-7. 2006..Secreted proteins from cancer cells may be potential serologic biomarkers of cancer. It's important to globally identify secreted proteins of cancer cells. This study was to identify secreted proteins of lung cancer cells...
- Spectrum of dentin dysplasia in a family: case report and literature reviewW K Seow
University of Queensland Dental School, Brisbane, Australia
Pediatr Dent 16:437-42. 1994The dentin dysplasias (DD), which may be classified as type 1 (DD1) or type 2 (DD2), form a group of rare, inherited dentin abnormalities that are clinically distinct from dentinogenesis imperfecta...
- Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activityK Matsuura
Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, 502 8585, Japan
J Biochem 124:940-6. 1998..dehydrogenase exists in four isoforms, which belong to the aldo-keto reductase (AKR) superfamily and are named AKR1C1-AKR1C4. The properties of AKR1C3 have not been fully characterized compared to the other isoforms...
- 20-alpha-Hydroxysteroid dehydrogenase from pseudopregnant rat ovary: obtention and characterization of a monoclonal antibody against the enzyme activityM P De La Llosa Hermier
Laboratoire de Biochimie des Hormones, CNRS, Gif sur Yvette, France
Biochimie 74:1117-20. 1992..Studies of Michaelis constants of 20-alpha-HSD indicate that this monoclonal antibody increases the Km for 20-alpha-dihydroprogesterone and decreases the Vmax...
- Identification of candidate genes associated with cell wall digestibility and eQTL (expression quantitative trait loci) analysis in a Flint x Flint maize recombinant inbred line populationChun Shi
Technical University of Munich, Am Hochanger 2, 85350 Freising, Germany
BMC Genomics 8:22. 2007..Cell-wall digestibility is the major target for improving the feeding value of forage maize. An understanding of the molecular basis for cell-wall digestibility is crucial towards breeding of highly digestible maize...
- A new classification system for the adult dysplastic hip requiring total hip arthroplasty: a reliability studyMark S Gaston
Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, UK
Hip Int 19:96-101. 2009Current classification systems used for developmental dysplasia of the hip (DDH) in adult patients about to undergo total hip arthroplasty use a combined assessment of the acetabulum and femur which ignores femoral geometry and problems ..
- Participation of ovarian 20 alpha-hydroxysteroid dehydrogenase in luteotrophic and luteolytic processes during rat pseudopregnancyJ Matsuda
Department of Veterinary Physiology, Faculty of Agriculture, University of Tokyo, Japan
J Reprod Fertil 88:467-74. 1990..abstract truncated at 250 words)..
- cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthaseT Suzuki
Second Department, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
J Biol Chem 274:241-8. 1999..79, 77, and 76% identity with the bovine lung PGF synthase and human liver dihydrodiol dehydrogenase (DD) isozymes DD1, DD2, and DD4, respectively...
- A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissuesYa Wen Cheng
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China
Environ Mol Mutagen 48:14-21. 2007..To determine whether a reduction in DDH expression changed the adduct levels, an siRNA was used to knock down DDH1 expression in CL-3 cells. The BaP adduct levels in siDDH-CL-3 cells increased 1.4-2...
- Androgen metabolism in adipose tissue: recent advancesKarine Blouin
Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Canada Department of Nutrition, Laval University, Canada
Mol Cell Endocrinol 301:97-103. 2009..This inhibitory effect is partially reversed by anti-androgens. Activity and mRNA expression of AKR1C1, 2 and 3 were detected in SC and OM adipose tissue, in men and women, with higher levels in the SC depot than the ..
- Effect of recombinant galectin-1 on the growth of immortal rat chondrocyte on chitosan-coated PLGA scaffoldShiang Jiuun Chen
Department of Life Science, Institute of Ecology and Evolutionary Biology and TechComm 5, College of Life Science, National Taiwan University, Taipei 106, Taiwan, Republic of China
J Biomed Mater Res A 93:1482-92. 2010..water absorption ratio of chitosan-modified PLGA scaffold was 70% higher than that of PLGA alone after immersion in ddH(2)O for 2 weeks, indicating that chitosan-modification significantly enhances the hydrophilicity of PLGA...
- Characterization of a salt-tolerant extracellular a-amylase from Bacillus dipsosauriC E Deutch
Division of Mathematics and Natural Sciences, Elmira College, NY, USA
Lett Appl Microbiol 35:78-84. 2002..The aims of this study were to purify and characterize an extracellular alpha-amylase from the salt-tolerant bacterium Bacillus dipsosauri...
- [Long-term management results of Pemberton's ilium osteotomy in combination with inter-trochanter derotation-varisation osteotomy in hip dysplasia of childhood]F Thielemann
Orthopädische Klinik und Poliklinik, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Germany
Z Orthop Ihre Grenzgeb 141:459-64. 2003..after a pericapsular osteotomy of the ilium (Pemberton) and a simultaneously performed derotation-varisation osteotomy of the proximal femur in children with developmental dysplasia of the hip (DDH) after the end of the maturity process.
- Simultaneous determination of piracetam and vincamine by spectrophotometric and high-performance liquid chromatographic methodsYasser Shaker Ibrahim El-Saharty
King Faisal University, Faculty of Clinical Pharmacy, Department of Pharmaceutical Analytical Chemistry, Al Hafhouf, PO Box 400, Kingdom of Saudi Arabia
J AOAC Int 91:311-21. 2008..The first was the determination of piracetam and vincamine using the ratio-spectra first-derivative (DD1) spectrophotometric technique at 209 and 293 nm in concentration ranges of 10-45 and 2-14 microg/mL with mean ..
- Essential role of diastolic oscillatory potentials in adrenergic control of guinea pig sino-atrial node dischargeMario Vassalle
Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
J Biomed Sci 16:101. 2009..The aim of this study was to investigate whether these oscillatory potentials are also involved in adrenergic control of SAN discharge...
- Mouse Dach, a homologue of Drosophila dachshund, is expressed in the developing retina, brain and limbsR J Davis
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Dev Genes Evol 209:526-36. 1999..Sequence analysis reveals the presence of two motifs, DD1 and DD2, which may be involved in the function of Dach/Dachshund as gene regulatory factors...
- Diagnosing childhood acetabular dysplasia using the lateral margin of the sourcilH T Kim
Department of Orthopaedic Surgery, Pusan National University Hospital, Korea
J Pediatr Orthop 20:709-17. 2000..We studied the radiographs of 53 patients with unilateral developmental dysplasia of the hip (DDH), all of whom were treated by closed reduction...
- Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and actionStephan Steckelbroeck
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
J Biol Chem 279:10784-95. 2004..Four human cytosolic aldo-keto reductases (AKR1C1-AKR1C4) are known to act as non-positional-specific 3alpha-/17beta-/20alpha-HSDs...
- Mechanobiological predictions of growth front morphology in developmental hip dysplasiaSandra J Shefelbine
VA Rehabilitation Research and Development Center, Stanford University, Palo Alto, CA 94305, USA
J Orthop Res 22:346-52. 2004Developmental dysplasia of the hip (DDH) is the most common orthopedic problem of newborn children...
- [Treatment of developmental dislocation of the hip with improved Pemberton method]Shouxin Cui
First Department of Orthopedics, Huxi Affiliated Hospital, Jining Medical College, Shanxian Central Hospital, Shanxian Shandong 274300, PR China
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:386-8. 2004To find a more perfect method of treating developmental dislocation of the hip(DDH).
- Diagnosis of developmental dislocation of the hip by sonospectrographyM I Safa Kapicioglu
Department of Orthopedic Surgery and Traumatology, Faculty of Medicine, Selcuk University, Meram, 42080, Konya, Turkey
Clin Orthop Relat Res 466:802-8. 2008Because not all infants can be screened for DDH by experts, early diagnosis of developmental dysplasia of the hip (DDH) by primary health care professionals is important...
- [Ultrasound in the diagnosis and treatment of developmental dysplasia of the hip. Evaluation of a selective screening procedure]Charlotte Strandberg
Gentofte Hospital, Billeddiagnostisk Afdeling
Ugeskr Laeger 170:235-40. 2008With the intention of reducing the treatment frequency of Developmental Dysplasia of the Hip (DDH), two hospitals in Copenhagen implemented a screening and treatment procedure based on selective referral to ultrasonography of the hip (US)..
- Biochemical and phylogenetic characterization of a novel diaminopimelate biosynthesis pathway in prokaryotes identifies a diverged form of LL-diaminopimelate aminotransferaseANDRE O HUDSON
Biotech Center and Department of Plant Biology and Pathology, Rutgers University, New Brunswick, New Jersey 08901, USA
J Bacteriol 190:3256-63. 2008..for dapD and dapE representing the acyl DAP pathway variants, and only in a few cases was dapL coincident with ddh encoding meso-DAP dehydrogenase...
- [Nonsurgical treatment of developmental dysplasia of the hip]M Nelitz
Orthopädische Universitätsklinik Ulm am RKU, Oberer Eselsberg 45, 89081, Ulm, Germany
Orthopade 37:550, 552-5. 2008The introduction of hip ultrasound for developmental dysplasia of the hip (DDH) has led to earlier diagnosis and treatment of this condition. The younger the child, the greater the potential of acetabular remodelling...
- Progesterone is extensively metabolized in osteoblasts: implications for progesterone action on boneM Quinkler
Clinical Endocrinology, Internal Medicine, Center for Gastroenterology, Hepatology and Endocrinology, Charite Campus Mitte, Charite University Medicine Berlin, Chariteplatz 1, Berlin, Germany
Horm Metab Res 40:679-84. 2008..This activity was concomitant with expression of mRNAs for the enzymes AKR1C1, 5 alpha-reductase type 1 and AKR1C2, and 3 beta-HSD type 1 and 3-hydroxysteroid epimerase...
- Femoral head deformity after open reduction by Ludloff's medial approachKunihiko Okano
Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
Clin Orthop Relat Res 466:2507-12. 2008..medial approach has been described as a simple procedure for open reduction of developmental dysplasia of the hip (DDH) requiring minimal dissection and tissue disruption...
- Comparison of morphologic and dynamic US methods in examination of the newborn hipPinar Kosar
Department of Radiology, Ankara Training and Research Hospital, Turkey
Diagn Interv Radiol 15:284-9. 2009Comparison of morphologic and dynamic methods of hip ultrasonography (US) to differentiate normal from abnormal findings in the diagnosis of developmental dysplasia of the hip (DDH).
- In vitro metabolism and identification of human enzymes involved in the metabolism of methylnaltrexoneZeen Tong
Pfizer Inc, Collegeville, PA 19426, USA
Drug Metab Dispos 38:801-7. 2010..5beta-Cholanic acid 3alpha,7alpha-diol, the AKR1C2 inhibitor, and medroxyprogesterone acetate, an inhibitor of AKR1C1, AKR1C2, and AKR1C4, inhibited MNTX reduction up to 67%. Other inhibitors were less potent...
- Late diagnosis of developmental dysplasia of the hip: an analysis of risk factorsThomas Azzopardi
Royal Hospital for Sick Children, Glasgow, UK
J Pediatr Orthop B 20:1-7. 2011A neonatal clinical screening program for developmental dysplasia of the hip (DDH) operates in South Australia to diagnose DDH as early as possible. However, some cases of DDH are diagnosed late (>3 months of age)...
- Modular neck prostheses in DDH patients: 11-year resultsFrancesco Traina
1st Department of Orthopaedic Surgery, Laboratory for Medical Technology LTM, Istituti Ortopedici Rizzoli, Via Pupilli 1, 40136, Bologna, Italy
J Orthop Sci 16:14-20. 2011....
- Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cellsJing Wang
Department of Applied Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China
Eur J Med Chem 46:1117-21. 2011..The interaction of 1 in ddH(2)O solution with Co(2+), Mn(2+), Zn(2+), Fe(2+) or Fe(3+) changed UV absorption values; the chelation of 1 with Fe(..
- Association of interleukin-6 and transforming growth factor-β1 gene polymorphisms with developmental hip dysplasia and severe adult hip osteoarthritis: a preliminary studyRobert Kolundzic
Department of Orthopedic Surgery, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia
Cytokine 54:125-8. 2011Developmental hip dysplasia (DDH) greatly contributes to occurrence of severe hip osteoarthritis (OA) in adulthood, but the association between the two is not a perfect one. Both conditions are known to have a strong genetic component...
- Dual diaminopimelate biosynthesis pathways in Bacteroides fragilis and Clostridium thermocellumANDRE O HUDSON
School of Biological and Sciences, Rochester Institute of Technology, Rochester, NY 14623, USA
Biochim Biophys Acta 1814:1162-8. 2011..Both species also contain an ortholog of meso-diaminopimelate dehydrogenase (Ddh), suggesting that they may have redundant pathways for DAP biosynthesis. The B...
- Interleukin 1β regulates progesterone metabolism in human cervical fibroblastsAmy E Roberson
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Reprod Sci 19:271-81. 2012..Human cervical fibroblasts were found to express AKR1C1, C2, and C3, with AKR1C1 exhibiting the greatest expression...
- Reliability of radiographic parameters in adults with hip dysplasiaTerje Terjesen
Department of Orthopaedics, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway
Skeletal Radiol 41:811-6. 2012To assess the reliability of radiographic measurements in adults previously treated for developmental dysplasia of the hip (DDH) and to clarify whether these parameters differ according to position of the patient (supine versus standing).
- [Early diagnosis of hip dysplasia. Crippling disease for life. Consensus of the Mexican College of Orthopedics and Traumatology]J Cymet-Ramírez
Colegio Mexicano de Ortopedia y Traumatología, Mexico
Acta Ortop Mex 25:313-22. 2011The developmental dysplasia of the hip (DDH), where the spectrum of deformity varies from a slight mismatch in the articular surfaces between the ilium and femur, which will bring a premature wear of the joint, until the situation more ..
- Ilfeld abduction orthosis is an effective second-line treatment after failure of Pavlik harness for infants with developmental dysplasia of the hipWudbhav N Sankar
Division of Orthopaedic Surgery, Children s Hospital of Philadelphia, Wood Building, 2nd Floor, 34th and Civic Center Boulevard, Philadelphia, PA 19104 E mail address for W N Sankar
J Bone Joint Surg Am 97:292-7. 2015..and spica casting is the most commonly recommended choice for infants with developmental dysplasia of the hip (DDH) for whom Pavlik harness treatment has failed, but it requires general anesthesia in addition to the challenges of ..
- The prevalence of developmental dysplasia of the hip in idiopathic clubfoot: a systematic review and meta-analysisTalal Ibrahim
Department of Orthopaedic Surgery, Hamad Medical Corporation, Doha, Qatar
Int Orthop 39:1371-8. 2015Developmental dysplasia of the hip (DDH) and idiopathic clubfoot are both common paediatric orthopaedic conditions...
- A common variant of ubiquinol-cytochrome c reductase complex is associated with DDHYe Sun
The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210061, China
PLoS ONE 10:e0120212. 2015Genetic basis of Developmental dysplasia of the hip (DDH) remains largely unknown. To find new susceptibility genes for DDH, we carried out a genome-wide association study (GWAS) for DDH.
- Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse modelKen Ming Chang
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Eur J Med Chem 106:60-74. 2015..In the animal experiment, Nrf2-mediated cytoprotective proteins, such as aldo-keto reductase 1 subunit C-1 (AKR1C1), glutathione reductase (GR), and heme oxygenase (HO-1), were obviously elevated in the liver of 17a-treated mice ..
- Acetabular Remodeling and Role of Osteotomy After Closed Reduction of Developmental Dysplasia of the HipChang Ho Shin
Division of Pediatric Orthopaedics, Seoul National University Children s Hospital, Seoul, Republic of Korea
J Bone Joint Surg Am 98:952-7. 2016The purposes of this study were to evaluate acetabular remodeling after closed reduction of developmental dysplasia of the hip (DDH) and to delineate the role of osteotomy.
- Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoformsTrevor M Penning
Department of Pharmacology, School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
J Steroid Biochem Mol Biol 85:247-55. 2003..Four human 3alpha-HSD isoforms exist and correspond to AKR1C1-AKR1C4 of the aldo-keto reductase (AKR) superfamily...
- Tarantulas: eight-legged pharmacists and combinatorial chemistsPierre Escoubas
Institut de Pharmacologie Moléculaire et Cellulaire CNRS, 660 route des Lucioles, Valbonne 06560, France
Toxicon 43:555-74. 2004..peptides show that tarantula toxins can fold according to an elaboration of the Disulfide-Directed beta-Hairpin (DDH) motif which is also the canonical motif for the ICK fold...
- Primary total hip arthroplasty with Asian-type AML total hip prosthesis: follow-up for more than 10 yearsMitsunori Kaya
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, Hokkaido, 060 8543, Japan
J Orthop Sci 13:324-7. 2008..would achieve durable biological fixation in the Japanese population in whom developmental dysplasia of the hip (DDH) is relatively common...
- The influence of the centre of rotation on implant survival using a modular stem hip prosthesisFrancesco Traina
1st Department of Orthopaedic Surgery and Laboratory of Medical Technology LTM, Istituti Ortopedici Rizzoli, Via Pupilli 1, Bologna, Italy, 40136
Int Orthop 33:1513-8. 2009..In all cases the preoperative diagnosis was dysplasia of the hip (DDH) and cementless modular neck prostheses with ceramic bearing surfaces were used...
- Hip sonography: 20 years experience and resultsR Graf
General and Orthopedic Hospital, Stolzalpe, Austria
Hip Int 17:S8-14. 2007Hip sonography in the "Graf technique" is an important tool to detect early DDH cases and dysplastic hips in the German speaking countries, although hip sonography is still controversially discussed in the English speaking countries...
- Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapyMartin Loignon
Segal Cancer Centre, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Mol Cancer Ther 8:2432-40. 2009..siRNA, we silenced Cul3 in MCF-7 breast cancer cells, and microarray analysis reveals the induction of GCL, NQO1, AKR1C1, UGDH, and TXN by at least 2-fold. The Nrf2-regulated ABCC1 drug transporter was also found to be increased...
- Long-term results of cementless anatomic total hip replacement in dysplastic hipsMatteo Bruzzone
Department of Orthopaedics and Traumatology, Mauriziano Umberto I Hospital, Turin, Italy
Chir Organi Mov 93:131-6. 2009..outcomes of cementless anatomic total hip arthroplasty (THA) in patients with developmental dysplasia of the hip (DDH). Between 1990 and 2004, 100 ABG total hip prosthesis were implanted in 87 patients with DDH...
- Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancerDavid J Stewart
Department of Thoracic Head and Neck Medical Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Crit Rev Oncol Hematol 75:173-234. 2010..with decreased expression of cyclin B1 or of Eg5, or with increased expression of ICAM, matrilysin, osteopontin, DDH, survivin, PCDGF, caveolin-1, p21WAF1/CIP1, or 14-3-3sigma, and that IGF-1R inhibitors may increase efficacy of ..
- The role of community screening for developmental dysplasia of the hip at the 8-month baby checkS J Cooke
Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, UK
Child Care Health Dev 37:1-4. 2011Screening for developmental dysplasia of the hip (DDH) after the neonatal period is controversial...
- Spica MRI after closed reduction for developmental dysplasia of the hipAditi A Desai
Vanderbilt University School of Medicine, 1211 Medical Center Drive, Nashville, TN 37232, USA
Pediatr Radiol 41:525-9. 2011..is a fast and effective tool to assess morphology after closed reduction for developmental dysplasia of the hip (DDH) without the need for sedation...
- Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesisOssama El-Kabbani
Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia
Bioorg Med Chem Lett 21:2564-7. 2011Human 20α-hydroxysteroid dehydrogenase (AKR1C1) is an important drug target due to its role in the development of lung and endometrial cancers, premature birth and neuronal disorders...
- Early results of total hip arthroplasty in patients with developmental dysplasia of the hip compared with patients with osteoarthritisMatthew J Boyle
Department of Paediatric Orthopaedics, Starship Children s Hospital, Auckland, New Zealand
J Arthroplasty 27:386-90. 2012..the results of primary total hip arthroplasty (THA) performed in patients with developmental dysplasia of the hip (DDH)...
- A meta-analysis of common risk factors associated with the diagnosis of developmental dysplasia of the hip in newbornsClara L Ortiz-Neira
Department of Radiology, Alberta Children s Hospital, University of Calgary, Faculty of Medicine, 2888 Shaganappi Trail NW, Calgary, Alberta, Canada T3B 6A8
Eur J Radiol 81:e344-51. 2012Although there is no clear consensus about the process of screening for developmental dysplasia of the hip (DDH), there are six common risk factors associated with DDH in patients less than 6 months of age (breech presentation, sex, ..
- Distribution of hip pain in osteoarthritis patients secondary to developmental dysplasia of the hipJunichi Nakamura
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba, 260 8677, Japan
Mod Rheumatol 23:119-24. 2013Our aim was to clarify the distribution of hip pain in patients with osteoarthritis of the hip secondary to developmental dysplasia of the hip (DDH).
- Total hip arthroplasty, hip osteoarthritis, total knee arthroplasty, and knee osteoarthritis in patients with developmental dysplasia of the hip and their family members: a kinship analysis reportAlison N Schiffern
Department of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA
J Pediatr Orthop 32:609-12. 2012Developmental dysplasia of the hip (DDH) is a familial condition with a wide phenotypic expression...
- N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3Maša Sinreih
Institute of Biochemistry, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
Bioorg Med Chem Lett 22:5948-51. 2012Human aldo-keto reductases AKR1C1-AKR1C3 are involved in the biosynthesis and inactivation of steroid hormones and prostaglandins and thus represent attractive targets for the development of new drugs...
- New enzymatic assay for the AKR1C enzymesNataša Beranič
Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Chem Biol Interact 202:204-9. 2013The imbalance in expression of the human aldo-keto reductases AKR1C1-AKR1C3 is related to different hormone dependent and independent cancers and some other diseases...
- Arthroscopic labral repair concomitantly performed with curved periacetabular osteotomyHiroshi Nakayama
Department of Orthopaedic Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya City, Hyogo, 663 8501, Japan
Knee Surg Sports Traumatol Arthrosc 22:938-41. 2014..Radiological examination showed developmental dysplasia of the hip (DDH) combined with acetabular retroversion and posterior wall deficiency...
- [Locomotor development in infants with developmental dysplasia of the hip or idiopathic clubfoot undergoing orthopedic treatment. Prospective comparative study]J J Masquijo
Departamento de Ortopedia y Traumatología Infantil, Sanatorio Allende, Cordoba, Argentina
An Pediatr (Barc) 79:236-40. 2013Several disorders of early childhood, such as developmental dysplasia of the hip (DDH) and clubfoot, requires orthopedic treatment that limits active mobility of the lower extremities for a period of time...
- Cementless total hip arthroplasty for patients with Crowe type III or IV developmental dysplasia of the hip: two-stage total hip arthroplasty following skeletal traction after soft tissue release for irreducible hipsPil Whan Yoon
Department of Orthopedic Surgery, Seoul National University Boramae Hospital, Seoul, Korea
Clin Orthop Surg 5:167-73. 2013Total hip arthroplasty (THA) for severe developmental dysplasia of the hip (DDH) is a technically demanding procedure for arthroplasty surgeons, and it is often difficult to reduce the hip joint without soft tissue release due to severe ..
- Androgen deficiency during mid- and late pregnancy alters progesterone production and metabolism in the porcine corpus luteumMalgorzata Grzesiak
1Department of Endocrinology, Institute of Zoology, Jagiellonian University in Krakow, Krakow, Poland
Reprod Sci 21:778-90. 2014..Decreased luteal 20α-hydroxysteroid dehydrogenase (AKR1C1) mRNA and protein levels were observed in the GD50F group...
- Factors associated with an unfavourable outcome after Salter innominate osteotomy in patients with unilateral developmental dysplasia of the hip: does occult dysplasia of the contralateral hip affect the outcome?H Kaneko
Department of Rehabilitation, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
Bone Joint J 96:1419-23. 2014..osteotomy is an effective reconstructive procedure for the treatment of developmental dysplasia of the hip (DDH), but some children have a poor outcome at skeletal maturity...
- Phylogenomic analysis shows that ‘Bacillus vanillea’ is a later heterotypic synonym of Bacillus siamensisChristopher A Dunlap
Crop Bioprotection Research Units, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, Peoria, IL, USA
Int J Syst Evol Microbiol 65:3507-10. 2015..Bacillus siamensis KCTC 13613T ( = BCC 22614T = KACC 16244T), with a calculated DNA–DNA hybridization (DDH) value of 91.2 % and an average nucleotide identity (ANI) of 98.9 %...
- Risk factors for avascular necrosis after closed reduction for developmental dysplasia of the hipMathew D Schur
Children s Orthopaedic Center, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop 69, Los Angeles, CA, 90027, USA
J Child Orthop 10:185-92. 2016The purpose of this study was to identify and evaluate risk factors of avascular necrosis (AVN) after closed treatment for developmental dysplasia of the hip (DDH).
- Satisfying Results of Primary Hip Arthroplasty in Patients With Hip Dysplasia at a Mean Followup of 20 YearsEna Colo
Department of Orthopaedic Surgery, Radboud University Medical Center, Nijmegen, Netherlands
Clin Orthop Relat Res 474:2462-2468. 2016Developmental dysplasia of the hip (DDH) is a common cause of secondary osteoarthritis (OA) in younger patients, and when end-stage OA develops, a THA can provide a solution...
- Reconstruction of the Shallow Acetabulum With a Combination of Autologous Bulk and Impaction Bone Grafting Fixed by CementMasaaki Maruyama
Department of Orthopedic Surgery, Shinonoi General Hospital, 666 1 Ai, Shinonoi, Nagano, 388 8004, Japan
Clin Orthop Relat Res 475:387-395. 2017..is a difficult technical problem during primary total hip arthroplasty (THA) in developmental dysplasia of the hip (DDH)...
- Radiographic imaging for treatment and follow-up of developmental dysplasia of the hipK A Murray
Shriners Hospital for Children, Department of Radiology, University of Utah Health Sciences Center, Salt Lalke City 84132, USA
Semin Ultrasound CT MR 22:306-40. 2001Developmental dysplasia of the hip (DDH) is a spectrum of abnormalities that can range from a very mild disturbance to a very severe process that is incapacitating later in life...
- Fibrillin 2 and Developmental Genetics of Hip Dysplasia in a Canine ModelRory Todhunter; Fiscal Year: 2009..by applicant): A key feature of inherited canine (CHD) and human hip dysplasia (developmental dysplasia of the hip, DDH) is hip joint laxity which results in hip instability, subluxation, and debilitating secondary osteoarthritis...
- METABOLIC EFFECTS OF THYROID HORMONEHerbert Samuels; Fiscal Year: 2009..is mediated by a short region of NRIF3 (amino acids 20-50) containing Ser28 which we refer to as Death Domain-1 (DD1). Mutation of Ser28 to Ala28 eliminates DD1-mediated apoptosis in breast cancer cells...
- Trevor M Penning; Fiscal Year: 2014DESCRIPTION (provided by applicant): Human Aldo-Keto Reductases (AKR1A1, AKR1C1-AKR1C4) catalyze the activation of polycyclic aromatic hydrocarbon (PAH) trans-dihydrodiols to yield catechols which autooxidize to electrophilic and redox-..
- Allen C Gao; Fiscal Year: 2014..demonstrated that IL-6 increases the expression of genes encoding many steroidogenic enzymes including HSD3B2 and AKR1C1-3 involved in androgen biosynthesis, which suggest that IL-6 may increase the levels of intraprostatic androgens...
- Dihydrodiol dehydrogenase mediates cisplatin resistanceHenry Simpkins; Fiscal Year: 2007..Transfection experiments showed that forced overexpression of only DDH1 induced cisplatin/carboplatin resistance in the parental cell lines...
- Prevention of Hip Dysplasia with Thermal EnergyMANDI LOPEZ; Fiscal Year: 2005..of thermal energy to reduce excessively lax coxofemoral joints in neonatal children and thereby help prevent DDH. The candidate of this application graduated magna cum laude from Humboldt State University with a B.S...
- Breast cancer and HRT: genetic susceptibility within th*Kathleen Malone; Fiscal Year: 2006..nucleotide polymorphisms (SNPs) and tagSNPs in the PGR gene, and the following progesterone metabolizing genes, AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2, and the CYP3A4 gene...
- Detroit Center for Research on Oral Health DisparitiesAmid Ismail; Fiscal Year: 2007..The community based partners, the City of Detroit Department of Health (DDH) and the Voices of Detroit Initiative (VODI) have strongly supported this theme...
- INTERPLAY OF E PROTEINS AND CYCLIN D1 DEPENDENT KINASESDONALD KOHTZ; Fiscal Year: 2001..We have evidence that inhibition of myogenic BHLH regulators by cyclin dD1-dependent kinases is mediated by E protein dependent kase sites...
- Molecular Mechanisms of Multistage CarcinogenesisTREVOR PENNING; Fiscal Year: 2006..By studying the discrete molecular events responsible for the causation of cancer this Program may lead to the early prevention and intervention of this disease. ..
- Symposium on Aldo-Keto Reductases & Toxicant MetabolismTREVOR PENNING; Fiscal Year: 2002..abstract_text> ..
- MECHANISMS OF ENZYMATIC REACTIONSPERRY FREY; Fiscal Year: 2006..unreadable] [unreadable]..
- Changes in Tumor DNA Methylation with DecitabineDavid Stewart; Fiscal Year: 2006..This preliminary look at individual genes may provide a molecular rationale for future decitabine therapeutic studies in specific relevant tumor types. ..
- ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFERPERRY FREY; Fiscal Year: 2006..The contributions of beta- amino acids produced by lysine 2,3-aminomutase and arginine 2,3-aminomutase to the functions of antibiotics are not known. The beta-aminoacids may become significant in drug development. ..
- IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONSScott Burchiel; Fiscal Year: 2001..Finally, in Aim 4 we will assess the role of monocyte and P450 expression by Western blot and RT-PCR methods in subsets of HPBMC and human cell lines (above). ..