AKR1C1

Summary

Gene Symbol: AKR1C1
Description: aldo-keto reductase family 1 member C1
Alias: 2-ALPHA-HSD, 20-ALPHA-HSD, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1 member C1, 20 alpha-hydroxysteroid dehydrogenase, aldo-keto reductase C, chlordecone reductase homolog HAKRC, dihydrodiol dehydrogenase 1, dihydrodiol dehydrogenase 1/2, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase isoform DD1, hepatic dihydrodiol dehydrogenase, high-affinity hepatic bile acid-binding protein, indanol dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, type II 3-alpha-hydroxysteroid dehydrogenase
Species: human

Top Publications

  1. ncbi cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family
    A Stolz
    Division of Gastrointestinal and Liver Diseases, University of Southern California School of Medicine, Los Angeles 90033
    J Biol Chem 268:10448-57. 1993
  2. ncbi Characterization of a human 20alpha-hydroxysteroid dehydrogenase
    Y Zhang
    Oncology and Molecular Endocrinology Research Center, CHUQ PCHUL and Laval University, Quebec, Quebec G1V 4G2, Canada
    J Mol Endocrinol 25:221-8. 2000
  3. ncbi Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution
    V Nahoum
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center, Quebec, Quebec G1V 4G2, Canada
    J Biol Chem 276:42091-8. 2001
  4. ncbi Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids
    Jean Francois Couture
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL 2705 boul Laurier, Ste Foy, QC, Canada G1V 4G2
    J Mol Biol 331:593-604. 2003
  5. ncbi [Non-tuberculous mycobacteriosis. What has been coming out]
    Akira Kajiki
    Department of Respiratory Medicine, National Hospital Organization Ohmuta National Hospital, Fukuoka, Japan
    Kekkaku 86:113-25. 2011
  6. ncbi Inhibition of induction of 20 alpha-hydroxysteroid dehydrogenase activity in rat corpora lutea in vitro by the progesterone antagonist RU486
    J T Uilenbroek
    Department of Endocrinology and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
    Life Sci 50:1173-8. 1992
  7. ncbi Dual regulation of luteal progesterone production by androstenedione during spontaneous and RU486-induced luteolysis in pregnant rats
    C M Telleria
    Laboratorio de Reproduccion y Lactancia, CRICYT CONICET, Mendoza, Argentina
    J Steroid Biochem Mol Biol 55:385-93. 1995
  8. pmc Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    T M Penning
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Biochem J 351:67-77. 2000
  9. ncbi Expression, purification and characterization of the rat luteal 20 alpha-hydroxysteroid dehydrogenase
    J Mao
    Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60612 7342, USA
    Endocrinology 138:182-90. 1997
  10. doi Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis
    N Hevir
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 191:217-26. 2011

Research Grants

  1. Fibrillin 2 and Developmental Genetics of Hip Dysplasia in a Canine Model
    Rory Todhunter; Fiscal Year: 2009
  2. METABOLIC EFFECTS OF THYROID HORMONE
    Herbert Samuels; Fiscal Year: 2009
  3. Trevor M Penning; Fiscal Year: 2014
  4. Allen C Gao; Fiscal Year: 2014
  5. Dihydrodiol dehydrogenase mediates cisplatin resistance
    Henry Simpkins; Fiscal Year: 2007
  6. Prevention of Hip Dysplasia with Thermal Energy
    MANDI LOPEZ; Fiscal Year: 2005
  7. Breast cancer and HRT: genetic susceptibility within th*
    Kathleen Malone; Fiscal Year: 2006
  8. Detroit Center for Research on Oral Health Disparities
    Amid Ismail; Fiscal Year: 2007
  9. INTERPLAY OF E PROTEINS AND CYCLIN D1 DEPENDENT KINASES
    DONALD KOHTZ; Fiscal Year: 2001
  10. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006

Detail Information

Publications250 found, 100 shown here

  1. ncbi cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family
    A Stolz
    Division of Gastrointestinal and Liver Diseases, University of Southern California School of Medicine, Los Angeles 90033
    J Biol Chem 268:10448-57. 1993
    ..identified one isoform of dihydrodiol dehydrogenase activity that expresses high affinity bile acid binding (HBAB) with minimal 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) activity for bile acids...
  2. ncbi Characterization of a human 20alpha-hydroxysteroid dehydrogenase
    Y Zhang
    Oncology and Molecular Endocrinology Research Center, CHUQ PCHUL and Laval University, Quebec, Quebec G1V 4G2, Canada
    J Mol Endocrinol 25:221-8. 2000
    ..The present study clearly indicates that the genuine human 20alpha-HSD belongs to the aldoketo reductase family, like the 20alpha-HSDs from other species...
  3. ncbi Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution
    V Nahoum
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center, Quebec, Quebec G1V 4G2, Canada
    J Biol Chem 276:42091-8. 2001
    ....
  4. ncbi Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids
    Jean Francois Couture
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL 2705 boul Laurier, Ste Foy, QC, Canada G1V 4G2
    J Mol Biol 331:593-604. 2003
    Human 20alpha-hydroxysteroid dehydrogenase (h20alpha-HSD; AKR1C1) catalyzes the transformation of progesterone (Prog) into 20alpha-hydroxy-progesterone (20alpha-OHProg)...
  5. ncbi [Non-tuberculous mycobacteriosis. What has been coming out]
    Akira Kajiki
    Department of Respiratory Medicine, National Hospital Organization Ohmuta National Hospital, Fukuoka, Japan
    Kekkaku 86:113-25. 2011
    ..of non-tuberculous mycobacteriosis is relatively easy, because of recent technological advances (HRCT, MGIT, PCR, DDH etc). Although many reports of this disease have been published, there are many problems to resolve...
  6. ncbi Inhibition of induction of 20 alpha-hydroxysteroid dehydrogenase activity in rat corpora lutea in vitro by the progesterone antagonist RU486
    J T Uilenbroek
    Department of Endocrinology and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
    Life Sci 50:1173-8. 1992
    ..However, since these effects in vitro can only be obtained with high concentrations of RU486, it is unlikely that this antiluteolytic effect plays a role after injection of RU486 in vivo...
  7. ncbi Dual regulation of luteal progesterone production by androstenedione during spontaneous and RU486-induced luteolysis in pregnant rats
    C M Telleria
    Laboratorio de Reproduccion y Lactancia, CRICYT CONICET, Mendoza, Argentina
    J Steroid Biochem Mol Biol 55:385-93. 1995
    ....
  8. pmc Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    T M Penning
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Biochem J 351:67-77. 2000
    ..1 3alpha-HSD (AKR1C4), type 2 3alpha(17beta)-HSD (AKR1C3), type 3 3alpha-HSD (AKR1C2) and 20alpha(3alpha)-HSD (AKR1C1), and share at least 84% amino acid sequence identity...
  9. ncbi Expression, purification and characterization of the rat luteal 20 alpha-hydroxysteroid dehydrogenase
    J Mao
    Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60612 7342, USA
    Endocrinology 138:182-90. 1997
    The enzyme, rat ovarian 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD), plays a central role in luteolysis and parturition...
  10. doi Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis
    N Hevir
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 191:217-26. 2011
    ..The aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) are the major reductive 20α-HSDs, while the oxidative reaction is catalyzed by 17β-HSD type 2 (..
  11. ncbi Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins
    T M Penning
    Department of Pharmacology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Mol Cell Endocrinol 215:63-72. 2004
    ..They share 86% sequence identity and correspond to: AKR1C1 (20 alpha(3 alpha)-HSD); AKR1C2 (type 3 3 alpha-HSD and bile-acid binding protein); AKR1C3 (type 2 3 alpha-HSD and ..
  12. ncbi Peripheral neuropathy in transgenic diabetic mice: restoration of C-fiber function with human recombinant nerve growth factor
    K A Elias
    Genentech, San Francisco, California 94080, USA
    Diabetes 47:1637-42. 1998
    Mice (Ins.Dd1) with hypoinsulinemic diabetes were created by increased expression of syngeneic major histocompatibility complex (MHC) class I protein in pancreatic beta-cells...
  13. ncbi [Geographic distribution of Mycobacterium avium-intracellulare complex serovars isolated from patients in five cities of Japan]
    A Sato
    Department of Bacteriology, Kobe Institute of Health, Hyogo, Japan
    Kansenshogaku Zasshi 74:64-72. 2000
    ..avium and M. intracellulare by DNA-DNA hybridization assay (DDH)...
  14. ncbi 3(20)alpha-hydroxysteroid dehydrogenase activity of monkey liver indanol dehydrogenase
    A Hara
    Department of Biochemistry, Gifu Pharmaceutical University
    J Biochem 106:900-3. 1989
    Homogeneous indanol dehydrogenase from monkey liver catalyzed the reversible conversion of 3 alpha- or 20 alpha-hydroxy groups of several bile acids and 5 beta-pregnanes to the corresponding 3- or 20-ketosteroids...
  15. ncbi Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone
    Yu Higaki
    Laboratory of Biochemistry, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585, Gifu, Japan
    Chem Biol Interact 143:503-13. 2003
    ..for the neuroactive steroids and their precursors among four human 3(20)alpha-hydroxysteroid dehydrogenases (AKR1C1-AKR1C4) suggests that AKR1C1 and AKR1C2 are involved in the catabolism and synthesis, respectively, of the ..
  16. ncbi Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid
    Stephan Steckelbroeck
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Mol Pharmacol 66:1702-11. 2004
    ..Homogeneous recombinant AKR1C1, AKR1C3, and AKR1C4 gave similar catalytic profiles to those observed with 5alpha-DHT...
  17. doi Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3
    N Beranič
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 191:227-33. 2011
    The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) are important 20-ketosteroid reductases in pre-receptor regulation of progesterone action...
  18. ncbi Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity
    W R Lacy
    Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030
    Mol Endocrinol 7:58-66. 1993
    ..up to 30% of the soluble proteins of the ovary, has been found to have 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD) activity...
  19. pmc Associated risk factors in children who had late presentation of developmental dysplasia of the hip
    Freih Odeh Abu Hassan
    Department of Orthopedics Surgery, Jordan University Hospital, P O Box 73 Jubaiha, Amman, 11941, Jordan
    J Child Orthop 1:205-10. 2007
    The purpose of this study was to assess the role of clinical examination, associated risk factors and plain radiograph of the pelvis in children who had late presentation of DDH.
  20. ncbi [The importance of predicted risk factors in developmental hip dysplasia: an ultrasonographic screening program]
    Levent Karapinar
    Department of Orthopedics and Traumatology 1 Ortopedi ve Travmatoloji Kliniği, Izmir SSK Training Hospital, 35380 Tepecik, Turkey
    Acta Orthop Traumatol Turc 36:106-10. 2002
    To evaluate the role of the risk factors in the diagnosis of developmental hip dysplasia (DDH) by ultrasonographic screening.
  21. ncbi [Ultrasound screening for hip dysplasia in newborns and treatment with Frejka pillow]
    Hans Christian Blom
    Tidsskr Nor Laegeforen 125:1998-2001. 2005
    The prevailing strategy concerning ultrasound screening for DDH in newborns in Norway does not intercept all who should be treated...
  22. ncbi Participation of intraluteal progesterone and prostaglandin F2 alpha in LH-induced luteolysis in pregnant rat
    C O Stocco
    , CRICYT CONICET, Mendoza, Argentina
    J Endocrinol 156:253-9. 1998
    ..Thus, the early decline in 3 beta-HSD activity and the consequent fall in intraluteal P4 content, may trigger the synthesis of PGs and thereafter the increase in luteal 20 alpha-HSD activity to establish luteolysis...
  23. ncbi [Identification of mycobacteria by sequencing of rpoB gene and 16S rRNA]
    Yuko Kazumi
    TB Information Division, Molecular Epidemiology and Genetic Identification, Mycobacterium Reference Center, Research Institute of Tuberculosis, JATA, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533 Japan
    Kekkaku 81:551-8. 2006
    To classify a specific Mycobacterium among various mycobacteria utilizing sequencing of rpoB gene. To classify mycobacteria not identified by DNA-DNA hybridization (DDH) using sequencing of rpoB and 16S rRNA gene.
  24. doi The evaluation of hip muscles in patients treated with one-stage combined procedure for unilateral developmental dysplasia of the hip: part I: MRI evaluation
    Halil Yalçın Yüksel
    Third Orthopaedics and Traumatology Clinic, Ankara Numune Educational and Research Hospital, Ankara, Turkey
    J Pediatr Orthop 29:872-8. 2009
    To assess the status of hip flexor and extensor muscles with MRI in patients with unilateral developmental dysplasia of the hip (DDH) after walking age who were treated with one-stage combined procedure.
  25. ncbi Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity
    N Wintergalen
    Zentrum für Frauenheilkunde, Westfalische Wilhelms Universitat, Munster, Germany
    Eur J Biochem 234:264-70. 1995
    ..For this reason the aldo-keto reductase could be a key enzyme in the cascade of events leading to the regression of the corpus luteum in the rabbit...
  26. ncbi Anterolateral muscle sparing approach total hip arthroplasty: an anatomic and clinical study
    Xian Long Zhang
    Department of Orthopaedics, Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Chin Med J (Engl) 121:1358-63. 2008
    ..In this study, a modified anterolateral muscle sparing approach was developed to optimize MIS-THA...
  27. doi Familial predisposition to developmental dysplasia of the hip
    David A Stevenson
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84132, USA
    J Pediatr Orthop 29:463-6. 2009
    Developmental dysplasia of the hip (DDH) is a common birth defect and is thought to have genetic contributions to the phenotype. It is likely that DDH is genetically heterogeneous with environmental modifiers...
  28. ncbi Effect of calyculin-A, phosphatase inhibitor, on 20 alpha-hydroxysteroid dehydrogenase activity in rat luteal cell culture
    K Yamanouchi
    Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Japan
    Endocr J 40:699-704. 1993
    ..These results suggest that a CL-A sensitive phosphatase(s) may be involved in the action of PRL in suppressing the increase in 20 alpha-HSD activity in rat luteal cells...
  29. ncbi Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array
    C Stocco
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois
    Endocrinology 142:4158-61. 2001
    ....
  30. pmc Characterization of the aldo-keto reductase 1C gene cluster on pig chromosome 10: possible associations with reproductive traits
    Dan J Nonneman
    USDA ARS, US Meat Animal Research Center, Clay Center, Nebraska, 68933, USA
    BMC Vet Res 2:28. 2006
    ..Because of their location in the swine genome and their implication in reproductive physiology, this gene cluster was characterized and evaluated for effects on reproductive traits in swine...
  31. ncbi Possible role of transforming growth factor-beta as a mediator of luteotropic action of prolactin in rat luteal cell cultures
    S Matsuyama
    Department of Veterinary Physiology, University of Tokyo, Japan
    Endocrinology 127:1561-7. 1990
    ..action in rats and enhances progesterone secretion by suppressing 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD) activity in the corpus luteum...
  32. ncbi Mechanoreceptor evaluation of hip joint capsule and ligamentum capitis femoris in developmental hip dysplasia: a preliminary study
    Hasan H Muratli
    Third Orthopedics and Traumatology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
    J Pediatr Orthop B 13:299-302. 2004
    ..in the hip joint capsule and ligamentum capitis femoris (LCF) of patients with developmental dysplasia of the hip (DDH). We took capsule and LCF biopsies from 20 hips of 20 patients who were operated on because of DDH...
  33. ncbi Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling
    Qing Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1361-9. 2007
    We previously reported the selective loss of AKR1C2 and AKR1C1 in prostate cancers compared with their expression in paired benign tissues...
  34. ncbi Proteomic analysis of secreted proteins of non-small cell lung cancer
    Ling Jin Huang
    Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P R China
    Ai Zheng 25:1361-7. 2006
    ..Secreted proteins from cancer cells may be potential serologic biomarkers of cancer. It's important to globally identify secreted proteins of cancer cells. This study was to identify secreted proteins of lung cancer cells...
  35. ncbi Spectrum of dentin dysplasia in a family: case report and literature review
    W K Seow
    University of Queensland Dental School, Brisbane, Australia
    Pediatr Dent 16:437-42. 1994
    The dentin dysplasias (DD), which may be classified as type 1 (DD1) or type 2 (DD2), form a group of rare, inherited dentin abnormalities that are clinically distinct from dentinogenesis imperfecta...
  36. ncbi Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity
    K Matsuura
    Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, 502 8585, Japan
    J Biochem 124:940-6. 1998
    ..dehydrogenase exists in four isoforms, which belong to the aldo-keto reductase (AKR) superfamily and are named AKR1C1-AKR1C4. The properties of AKR1C3 have not been fully characterized compared to the other isoforms...
  37. ncbi 20-alpha-Hydroxysteroid dehydrogenase from pseudopregnant rat ovary: obtention and characterization of a monoclonal antibody against the enzyme activity
    M P De La Llosa Hermier
    Laboratoire de Biochimie des Hormones, CNRS, Gif sur Yvette, France
    Biochimie 74:1117-20. 1992
    ..Studies of Michaelis constants of 20-alpha-HSD indicate that this monoclonal antibody increases the Km for 20-alpha-dihydroprogesterone and decreases the Vmax...
  38. pmc Identification of candidate genes associated with cell wall digestibility and eQTL (expression quantitative trait loci) analysis in a Flint x Flint maize recombinant inbred line population
    Chun Shi
    Technical University of Munich, Am Hochanger 2, 85350 Freising, Germany
    BMC Genomics 8:22. 2007
    ..Cell-wall digestibility is the major target for improving the feeding value of forage maize. An understanding of the molecular basis for cell-wall digestibility is crucial towards breeding of highly digestible maize...
  39. ncbi A new classification system for the adult dysplastic hip requiring total hip arthroplasty: a reliability study
    Mark S Gaston
    Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, UK
    Hip Int 19:96-101. 2009
    Current classification systems used for developmental dysplasia of the hip (DDH) in adult patients about to undergo total hip arthroplasty use a combined assessment of the acetabulum and femur which ignores femoral geometry and problems ..
  40. ncbi Participation of ovarian 20 alpha-hydroxysteroid dehydrogenase in luteotrophic and luteolytic processes during rat pseudopregnancy
    J Matsuda
    Department of Veterinary Physiology, Faculty of Agriculture, University of Tokyo, Japan
    J Reprod Fertil 88:467-74. 1990
    ..abstract truncated at 250 words)..
  41. ncbi cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase
    T Suzuki
    Second Department, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 274:241-8. 1999
    ..79, 77, and 76% identity with the bovine lung PGF synthase and human liver dihydrodiol dehydrogenase (DD) isozymes DD1, DD2, and DD4, respectively...
  42. ncbi A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues
    Ya Wen Cheng
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Environ Mol Mutagen 48:14-21. 2007
    ..To determine whether a reduction in DDH expression changed the adduct levels, an siRNA was used to knock down DDH1 expression in CL-3 cells. The BaP adduct levels in siDDH-CL-3 cells increased 1.4-2...
  43. doi Androgen metabolism in adipose tissue: recent advances
    Karine Blouin
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Canada Department of Nutrition, Laval University, Canada
    Mol Cell Endocrinol 301:97-103. 2009
    ..This inhibitory effect is partially reversed by anti-androgens. Activity and mRNA expression of AKR1C1, 2 and 3 were detected in SC and OM adipose tissue, in men and women, with higher levels in the SC depot than the ..
  44. doi Effect of recombinant galectin-1 on the growth of immortal rat chondrocyte on chitosan-coated PLGA scaffold
    Shiang Jiuun Chen
    Department of Life Science, Institute of Ecology and Evolutionary Biology and TechComm 5, College of Life Science, National Taiwan University, Taipei 106, Taiwan, Republic of China
    J Biomed Mater Res A 93:1482-92. 2010
    ..water absorption ratio of chitosan-modified PLGA scaffold was 70% higher than that of PLGA alone after immersion in ddH(2)O for 2 weeks, indicating that chitosan-modification significantly enhances the hydrophilicity of PLGA...
  45. ncbi Characterization of a salt-tolerant extracellular a-amylase from Bacillus dipsosauri
    C E Deutch
    Division of Mathematics and Natural Sciences, Elmira College, NY, USA
    Lett Appl Microbiol 35:78-84. 2002
    ..The aims of this study were to purify and characterize an extracellular alpha-amylase from the salt-tolerant bacterium Bacillus dipsosauri...
  46. ncbi [Long-term management results of Pemberton's ilium osteotomy in combination with inter-trochanter derotation-varisation osteotomy in hip dysplasia of childhood]
    F Thielemann
    Orthopädische Klinik und Poliklinik, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Germany
    Z Orthop Ihre Grenzgeb 141:459-64. 2003
    ..after a pericapsular osteotomy of the ilium (Pemberton) and a simultaneously performed derotation-varisation osteotomy of the proximal femur in children with developmental dysplasia of the hip (DDH) after the end of the maturity process.
  47. ncbi Simultaneous determination of piracetam and vincamine by spectrophotometric and high-performance liquid chromatographic methods
    Yasser Shaker Ibrahim El-Saharty
    King Faisal University, Faculty of Clinical Pharmacy, Department of Pharmaceutical Analytical Chemistry, Al Hafhouf, PO Box 400, Kingdom of Saudi Arabia
    J AOAC Int 91:311-21. 2008
    ..The first was the determination of piracetam and vincamine using the ratio-spectra first-derivative (DD1) spectrophotometric technique at 209 and 293 nm in concentration ranges of 10-45 and 2-14 microg/mL with mean ..
  48. pmc Essential role of diastolic oscillatory potentials in adrenergic control of guinea pig sino-atrial node discharge
    Mario Vassalle
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
    J Biomed Sci 16:101. 2009
    ..The aim of this study was to investigate whether these oscillatory potentials are also involved in adrenergic control of SAN discharge...
  49. ncbi Mouse Dach, a homologue of Drosophila dachshund, is expressed in the developing retina, brain and limbs
    R J Davis
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Genes Evol 209:526-36. 1999
    ..Sequence analysis reveals the presence of two motifs, DD1 and DD2, which may be involved in the function of Dach/Dachshund as gene regulatory factors...
  50. ncbi Diagnosing childhood acetabular dysplasia using the lateral margin of the sourcil
    H T Kim
    Department of Orthopaedic Surgery, Pusan National University Hospital, Korea
    J Pediatr Orthop 20:709-17. 2000
    ..We studied the radiographs of 53 patients with unilateral developmental dysplasia of the hip (DDH), all of whom were treated by closed reduction...
  51. ncbi Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action
    Stephan Steckelbroeck
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    J Biol Chem 279:10784-95. 2004
    ..Four human cytosolic aldo-keto reductases (AKR1C1-AKR1C4) are known to act as non-positional-specific 3alpha-/17beta-/20alpha-HSDs...
  52. ncbi Mechanobiological predictions of growth front morphology in developmental hip dysplasia
    Sandra J Shefelbine
    VA Rehabilitation Research and Development Center, Stanford University, Palo Alto, CA 94305, USA
    J Orthop Res 22:346-52. 2004
    Developmental dysplasia of the hip (DDH) is the most common orthopedic problem of newborn children...
  53. ncbi [Treatment of developmental dislocation of the hip with improved Pemberton method]
    Shouxin Cui
    First Department of Orthopedics, Huxi Affiliated Hospital, Jining Medical College, Shanxian Central Hospital, Shanxian Shandong 274300, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:386-8. 2004
    To find a more perfect method of treating developmental dislocation of the hip(DDH).
  54. pmc Diagnosis of developmental dislocation of the hip by sonospectrography
    M I Safa Kapicioglu
    Department of Orthopedic Surgery and Traumatology, Faculty of Medicine, Selcuk University, Meram, 42080, Konya, Turkey
    Clin Orthop Relat Res 466:802-8. 2008
    Because not all infants can be screened for DDH by experts, early diagnosis of developmental dysplasia of the hip (DDH) by primary health care professionals is important...
  55. ncbi [Ultrasound in the diagnosis and treatment of developmental dysplasia of the hip. Evaluation of a selective screening procedure]
    Charlotte Strandberg
    Gentofte Hospital, Billeddiagnostisk Afdeling
    Ugeskr Laeger 170:235-40. 2008
    With the intention of reducing the treatment frequency of Developmental Dysplasia of the Hip (DDH), two hospitals in Copenhagen implemented a screening and treatment procedure based on selective referral to ultrasonography of the hip (US)..
  56. pmc Biochemical and phylogenetic characterization of a novel diaminopimelate biosynthesis pathway in prokaryotes identifies a diverged form of LL-diaminopimelate aminotransferase
    ANDRE O HUDSON
    Biotech Center and Department of Plant Biology and Pathology, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Bacteriol 190:3256-63. 2008
    ..for dapD and dapE representing the acyl DAP pathway variants, and only in a few cases was dapL coincident with ddh encoding meso-DAP dehydrogenase...
  57. doi [Nonsurgical treatment of developmental dysplasia of the hip]
    M Nelitz
    Orthopädische Universitätsklinik Ulm am RKU, Oberer Eselsberg 45, 89081, Ulm, Germany
    Orthopade 37:550, 552-5. 2008
    The introduction of hip ultrasound for developmental dysplasia of the hip (DDH) has led to earlier diagnosis and treatment of this condition. The younger the child, the greater the potential of acetabular remodelling...
  58. doi Progesterone is extensively metabolized in osteoblasts: implications for progesterone action on bone
    M Quinkler
    Clinical Endocrinology, Internal Medicine, Center for Gastroenterology, Hepatology and Endocrinology, Charite Campus Mitte, Charite University Medicine Berlin, Chariteplatz 1, Berlin, Germany
    Horm Metab Res 40:679-84. 2008
    ..This activity was concomitant with expression of mRNAs for the enzymes AKR1C1, 5 alpha-reductase type 1 and AKR1C2, and 3 beta-HSD type 1 and 3-hydroxysteroid epimerase...
  59. pmc Femoral head deformity after open reduction by Ludloff's medial approach
    Kunihiko Okano
    Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Clin Orthop Relat Res 466:2507-12. 2008
    ..medial approach has been described as a simple procedure for open reduction of developmental dysplasia of the hip (DDH) requiring minimal dissection and tissue disruption...
  60. doi Comparison of morphologic and dynamic US methods in examination of the newborn hip
    Pinar Kosar
    Department of Radiology, Ankara Training and Research Hospital, Turkey
    Diagn Interv Radiol 15:284-9. 2009
    Comparison of morphologic and dynamic methods of hip ultrasonography (US) to differentiate normal from abnormal findings in the diagnosis of developmental dysplasia of the hip (DDH).
  61. doi In vitro metabolism and identification of human enzymes involved in the metabolism of methylnaltrexone
    Zeen Tong
    Pfizer Inc, Collegeville, PA 19426, USA
    Drug Metab Dispos 38:801-7. 2010
    ..5beta-Cholanic acid 3alpha,7alpha-diol, the AKR1C2 inhibitor, and medroxyprogesterone acetate, an inhibitor of AKR1C1, AKR1C2, and AKR1C4, inhibited MNTX reduction up to 67%. Other inhibitors were less potent...
  62. doi Late diagnosis of developmental dysplasia of the hip: an analysis of risk factors
    Thomas Azzopardi
    Royal Hospital for Sick Children, Glasgow, UK
    J Pediatr Orthop B 20:1-7. 2011
    A neonatal clinical screening program for developmental dysplasia of the hip (DDH) operates in South Australia to diagnose DDH as early as possible. However, some cases of DDH are diagnosed late (>3 months of age)...
  63. doi Modular neck prostheses in DDH patients: 11-year results
    Francesco Traina
    1st Department of Orthopaedic Surgery, Laboratory for Medical Technology LTM, Istituti Ortopedici Rizzoli, Via Pupilli 1, 40136, Bologna, Italy
    J Orthop Sci 16:14-20. 2011
    ....
  64. doi Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells
    Jing Wang
    Department of Applied Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China
    Eur J Med Chem 46:1117-21. 2011
    ..The interaction of 1 in ddH(2)O solution with Co(2+), Mn(2+), Zn(2+), Fe(2+) or Fe(3+) changed UV absorption values; the chelation of 1 with Fe(..
  65. doi Association of interleukin-6 and transforming growth factor-β1 gene polymorphisms with developmental hip dysplasia and severe adult hip osteoarthritis: a preliminary study
    Robert Kolundzic
    Department of Orthopedic Surgery, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia
    Cytokine 54:125-8. 2011
    Developmental hip dysplasia (DDH) greatly contributes to occurrence of severe hip osteoarthritis (OA) in adulthood, but the association between the two is not a perfect one. Both conditions are known to have a strong genetic component...
  66. doi Dual diaminopimelate biosynthesis pathways in Bacteroides fragilis and Clostridium thermocellum
    ANDRE O HUDSON
    School of Biological and Sciences, Rochester Institute of Technology, Rochester, NY 14623, USA
    Biochim Biophys Acta 1814:1162-8. 2011
    ..Both species also contain an ortholog of meso-diaminopimelate dehydrogenase (Ddh), suggesting that they may have redundant pathways for DAP biosynthesis. The B...
  67. doi Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts
    Amy E Roberson
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Reprod Sci 19:271-81. 2012
    ..Human cervical fibroblasts were found to express AKR1C1, C2, and C3, with AKR1C1 exhibiting the greatest expression...
  68. doi Reliability of radiographic parameters in adults with hip dysplasia
    Terje Terjesen
    Department of Orthopaedics, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway
    Skeletal Radiol 41:811-6. 2012
    To assess the reliability of radiographic measurements in adults previously treated for developmental dysplasia of the hip (DDH) and to clarify whether these parameters differ according to position of the patient (supine versus standing).
  69. ncbi [Early diagnosis of hip dysplasia. Crippling disease for life. Consensus of the Mexican College of Orthopedics and Traumatology]
    J Cymet-Ramírez
    Colegio Mexicano de Ortopedia y Traumatología, Mexico
    Acta Ortop Mex 25:313-22. 2011
    The developmental dysplasia of the hip (DDH), where the spectrum of deformity varies from a slight mismatch in the articular surfaces between the ilium and femur, which will bring a premature wear of the joint, until the situation more ..
  70. doi Ilfeld abduction orthosis is an effective second-line treatment after failure of Pavlik harness for infants with developmental dysplasia of the hip
    Wudbhav N Sankar
    Division of Orthopaedic Surgery, Children s Hospital of Philadelphia, Wood Building, 2nd Floor, 34th and Civic Center Boulevard, Philadelphia, PA 19104 E mail address for W N Sankar
    J Bone Joint Surg Am 97:292-7. 2015
    ..and spica casting is the most commonly recommended choice for infants with developmental dysplasia of the hip (DDH) for whom Pavlik harness treatment has failed, but it requires general anesthesia in addition to the challenges of ..
  71. doi The prevalence of developmental dysplasia of the hip in idiopathic clubfoot: a systematic review and meta-analysis
    Talal Ibrahim
    Department of Orthopaedic Surgery, Hamad Medical Corporation, Doha, Qatar
    Int Orthop 39:1371-8. 2015
    Developmental dysplasia of the hip (DDH) and idiopathic clubfoot are both common paediatric orthopaedic conditions...
  72. pmc A common variant of ubiquinol-cytochrome c reductase complex is associated with DDH
    Ye Sun
    The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210061, China
    PLoS ONE 10:e0120212. 2015
    Genetic basis of Developmental dysplasia of the hip (DDH) remains largely unknown. To find new susceptibility genes for DDH, we carried out a genome-wide association study (GWAS) for DDH.
  73. doi Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model
    Ken Ming Chang
    School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Eur J Med Chem 106:60-74. 2015
    ..In the animal experiment, Nrf2-mediated cytoprotective proteins, such as aldo-keto reductase 1 subunit C-1 (AKR1C1), glutathione reductase (GR), and heme oxygenase (HO-1), were obviously elevated in the liver of 17a-treated mice ..
  74. doi Acetabular Remodeling and Role of Osteotomy After Closed Reduction of Developmental Dysplasia of the Hip
    Chang Ho Shin
    Division of Pediatric Orthopaedics, Seoul National University Children s Hospital, Seoul, Republic of Korea
    J Bone Joint Surg Am 98:952-7. 2016
    The purposes of this study were to evaluate acetabular remodeling after closed reduction of developmental dysplasia of the hip (DDH) and to delineate the role of osteotomy.
  75. ncbi Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms
    Trevor M Penning
    Department of Pharmacology, School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Steroid Biochem Mol Biol 85:247-55. 2003
    ..Four human 3alpha-HSD isoforms exist and correspond to AKR1C1-AKR1C4 of the aldo-keto reductase (AKR) superfamily...
  76. ncbi Tarantulas: eight-legged pharmacists and combinatorial chemists
    Pierre Escoubas
    Institut de Pharmacologie Moléculaire et Cellulaire CNRS, 660 route des Lucioles, Valbonne 06560, France
    Toxicon 43:555-74. 2004
    ..peptides show that tarantula toxins can fold according to an elaboration of the Disulfide-Directed beta-Hairpin (DDH) motif which is also the canonical motif for the ICK fold...
  77. doi Primary total hip arthroplasty with Asian-type AML total hip prosthesis: follow-up for more than 10 years
    Mitsunori Kaya
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, Hokkaido, 060 8543, Japan
    J Orthop Sci 13:324-7. 2008
    ..would achieve durable biological fixation in the Japanese population in whom developmental dysplasia of the hip (DDH) is relatively common...
  78. pmc The influence of the centre of rotation on implant survival using a modular stem hip prosthesis
    Francesco Traina
    1st Department of Orthopaedic Surgery and Laboratory of Medical Technology LTM, Istituti Ortopedici Rizzoli, Via Pupilli 1, Bologna, Italy, 40136
    Int Orthop 33:1513-8. 2009
    ..In all cases the preoperative diagnosis was dysplasia of the hip (DDH) and cementless modular neck prostheses with ceramic bearing surfaces were used...
  79. ncbi Hip sonography: 20 years experience and results
    R Graf
    General and Orthopedic Hospital, Stolzalpe, Austria
    Hip Int 17:S8-14. 2007
    Hip sonography in the "Graf technique" is an important tool to detect early DDH cases and dysplastic hips in the German speaking countries, although hip sonography is still controversially discussed in the English speaking countries...
  80. doi Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy
    Martin Loignon
    Segal Cancer Centre, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Mol Cancer Ther 8:2432-40. 2009
    ..siRNA, we silenced Cul3 in MCF-7 breast cancer cells, and microarray analysis reveals the induction of GCL, NQO1, AKR1C1, UGDH, and TXN by at least 2-fold. The Nrf2-regulated ABCC1 drug transporter was also found to be increased...
  81. doi Long-term results of cementless anatomic total hip replacement in dysplastic hips
    Matteo Bruzzone
    Department of Orthopaedics and Traumatology, Mauriziano Umberto I Hospital, Turin, Italy
    Chir Organi Mov 93:131-6. 2009
    ..outcomes of cementless anatomic total hip arthroplasty (THA) in patients with developmental dysplasia of the hip (DDH). Between 1990 and 2004, 100 ABG total hip prosthesis were implanted in 87 patients with DDH...
  82. pmc Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer
    David J Stewart
    Department of Thoracic Head and Neck Medical Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Crit Rev Oncol Hematol 75:173-234. 2010
    ..with decreased expression of cyclin B1 or of Eg5, or with increased expression of ICAM, matrilysin, osteopontin, DDH, survivin, PCDGF, caveolin-1, p21WAF1/CIP1, or 14-3-3sigma, and that IGF-1R inhibitors may increase efficacy of ..
  83. doi The role of community screening for developmental dysplasia of the hip at the 8-month baby check
    S J Cooke
    Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, UK
    Child Care Health Dev 37:1-4. 2011
    Screening for developmental dysplasia of the hip (DDH) after the neonatal period is controversial...
  84. doi Spica MRI after closed reduction for developmental dysplasia of the hip
    Aditi A Desai
    Vanderbilt University School of Medicine, 1211 Medical Center Drive, Nashville, TN 37232, USA
    Pediatr Radiol 41:525-9. 2011
    ..is a fast and effective tool to assess morphology after closed reduction for developmental dysplasia of the hip (DDH) without the need for sedation...
  85. doi Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis
    Ossama El-Kabbani
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia
    Bioorg Med Chem Lett 21:2564-7. 2011
    Human 20α-hydroxysteroid dehydrogenase (AKR1C1) is an important drug target due to its role in the development of lung and endometrial cancers, premature birth and neuronal disorders...
  86. doi Early results of total hip arthroplasty in patients with developmental dysplasia of the hip compared with patients with osteoarthritis
    Matthew J Boyle
    Department of Paediatric Orthopaedics, Starship Children s Hospital, Auckland, New Zealand
    J Arthroplasty 27:386-90. 2012
    ..the results of primary total hip arthroplasty (THA) performed in patients with developmental dysplasia of the hip (DDH)...
  87. doi A meta-analysis of common risk factors associated with the diagnosis of developmental dysplasia of the hip in newborns
    Clara L Ortiz-Neira
    Department of Radiology, Alberta Children s Hospital, University of Calgary, Faculty of Medicine, 2888 Shaganappi Trail NW, Calgary, Alberta, Canada T3B 6A8
    Eur J Radiol 81:e344-51. 2012
    Although there is no clear consensus about the process of screening for developmental dysplasia of the hip (DDH), there are six common risk factors associated with DDH in patients less than 6 months of age (breech presentation, sex, ..
  88. doi Distribution of hip pain in osteoarthritis patients secondary to developmental dysplasia of the hip
    Junichi Nakamura
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba, 260 8677, Japan
    Mod Rheumatol 23:119-24. 2013
    Our aim was to clarify the distribution of hip pain in patients with osteoarthritis of the hip secondary to developmental dysplasia of the hip (DDH).
  89. doi Total hip arthroplasty, hip osteoarthritis, total knee arthroplasty, and knee osteoarthritis in patients with developmental dysplasia of the hip and their family members: a kinship analysis report
    Alison N Schiffern
    Department of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA
    J Pediatr Orthop 32:609-12. 2012
    Developmental dysplasia of the hip (DDH) is a familial condition with a wide phenotypic expression...
  90. pmc N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3
    Maša Sinreih
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
    Bioorg Med Chem Lett 22:5948-51. 2012
    Human aldo-keto reductases AKR1C1-AKR1C3 are involved in the biosynthesis and inactivation of steroid hormones and prostaglandins and thus represent attractive targets for the development of new drugs...
  91. doi New enzymatic assay for the AKR1C enzymes
    Nataša Beranič
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 202:204-9. 2013
    The imbalance in expression of the human aldo-keto reductases AKR1C1-AKR1C3 is related to different hormone dependent and independent cancers and some other diseases...
  92. pmc Arthroscopic labral repair concomitantly performed with curved periacetabular osteotomy
    Hiroshi Nakayama
    Department of Orthopaedic Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya City, Hyogo, 663 8501, Japan
    Knee Surg Sports Traumatol Arthrosc 22:938-41. 2014
    ..Radiological examination showed developmental dysplasia of the hip (DDH) combined with acetabular retroversion and posterior wall deficiency...
  93. doi [Locomotor development in infants with developmental dysplasia of the hip or idiopathic clubfoot undergoing orthopedic treatment. Prospective comparative study]
    J J Masquijo
    Departamento de Ortopedia y Traumatología Infantil, Sanatorio Allende, Cordoba, Argentina
    An Pediatr (Barc) 79:236-40. 2013
    Several disorders of early childhood, such as developmental dysplasia of the hip (DDH) and clubfoot, requires orthopedic treatment that limits active mobility of the lower extremities for a period of time...
  94. pmc Cementless total hip arthroplasty for patients with Crowe type III or IV developmental dysplasia of the hip: two-stage total hip arthroplasty following skeletal traction after soft tissue release for irreducible hips
    Pil Whan Yoon
    Department of Orthopedic Surgery, Seoul National University Boramae Hospital, Seoul, Korea
    Clin Orthop Surg 5:167-73. 2013
    Total hip arthroplasty (THA) for severe developmental dysplasia of the hip (DDH) is a technically demanding procedure for arthroplasty surgeons, and it is often difficult to reduce the hip joint without soft tissue release due to severe ..
  95. pmc Androgen deficiency during mid- and late pregnancy alters progesterone production and metabolism in the porcine corpus luteum
    Malgorzata Grzesiak
    1Department of Endocrinology, Institute of Zoology, Jagiellonian University in Krakow, Krakow, Poland
    Reprod Sci 21:778-90. 2014
    ..Decreased luteal 20α-hydroxysteroid dehydrogenase (AKR1C1) mRNA and protein levels were observed in the GD50F group...
  96. doi Factors associated with an unfavourable outcome after Salter innominate osteotomy in patients with unilateral developmental dysplasia of the hip: does occult dysplasia of the contralateral hip affect the outcome?
    H Kaneko
    Department of Rehabilitation, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Bone Joint J 96:1419-23. 2014
    ..osteotomy is an effective reconstructive procedure for the treatment of developmental dysplasia of the hip (DDH), but some children have a poor outcome at skeletal maturity...
  97. doi Phylogenomic analysis shows that ‘Bacillus vanillea’ is a later heterotypic synonym of Bacillus siamensis
    Christopher A Dunlap
    Crop Bioprotection Research Units, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, Peoria, IL, USA
    Int J Syst Evol Microbiol 65:3507-10. 2015
    ..Bacillus siamensis KCTC 13613T ( = BCC 22614T = KACC 16244T), with a calculated DNA–DNA hybridization (DDH) value of 91.2 % and an average nucleotide identity (ANI) of 98.9 %...
  98. pmc Risk factors for avascular necrosis after closed reduction for developmental dysplasia of the hip
    Mathew D Schur
    Children s Orthopaedic Center, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop 69, Los Angeles, CA, 90027, USA
    J Child Orthop 10:185-92. 2016
    The purpose of this study was to identify and evaluate risk factors of avascular necrosis (AVN) after closed treatment for developmental dysplasia of the hip (DDH).
  99. pmc Satisfying Results of Primary Hip Arthroplasty in Patients With Hip Dysplasia at a Mean Followup of 20 Years
    Ena Colo
    Department of Orthopaedic Surgery, Radboud University Medical Center, Nijmegen, Netherlands
    Clin Orthop Relat Res 474:2462-2468. 2016
    Developmental dysplasia of the hip (DDH) is a common cause of secondary osteoarthritis (OA) in younger patients, and when end-stage OA develops, a THA can provide a solution...
  100. pmc Reconstruction of the Shallow Acetabulum With a Combination of Autologous Bulk and Impaction Bone Grafting Fixed by Cement
    Masaaki Maruyama
    Department of Orthopedic Surgery, Shinonoi General Hospital, 666 1 Ai, Shinonoi, Nagano, 388 8004, Japan
    Clin Orthop Relat Res 475:387-395. 2017
    ..is a difficult technical problem during primary total hip arthroplasty (THA) in developmental dysplasia of the hip (DDH)...
  101. ncbi Radiographic imaging for treatment and follow-up of developmental dysplasia of the hip
    K A Murray
    Shriners Hospital for Children, Department of Radiology, University of Utah Health Sciences Center, Salt Lalke City 84132, USA
    Semin Ultrasound CT MR 22:306-40. 2001
    Developmental dysplasia of the hip (DDH) is a spectrum of abnormalities that can range from a very mild disturbance to a very severe process that is incapacitating later in life...

Research Grants18

  1. Fibrillin 2 and Developmental Genetics of Hip Dysplasia in a Canine Model
    Rory Todhunter; Fiscal Year: 2009
    ..by applicant): A key feature of inherited canine (CHD) and human hip dysplasia (developmental dysplasia of the hip, DDH) is hip joint laxity which results in hip instability, subluxation, and debilitating secondary osteoarthritis...
  2. METABOLIC EFFECTS OF THYROID HORMONE
    Herbert Samuels; Fiscal Year: 2009
    ..is mediated by a short region of NRIF3 (amino acids 20-50) containing Ser28 which we refer to as Death Domain-1 (DD1). Mutation of Ser28 to Ala28 eliminates DD1-mediated apoptosis in breast cancer cells...
  3. Trevor M Penning; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Human Aldo-Keto Reductases (AKR1A1, AKR1C1-AKR1C4) catalyze the activation of polycyclic aromatic hydrocarbon (PAH) trans-dihydrodiols to yield catechols which autooxidize to electrophilic and redox-..
  4. Allen C Gao; Fiscal Year: 2014
    ..demonstrated that IL-6 increases the expression of genes encoding many steroidogenic enzymes including HSD3B2 and AKR1C1-3 involved in androgen biosynthesis, which suggest that IL-6 may increase the levels of intraprostatic androgens...
  5. Dihydrodiol dehydrogenase mediates cisplatin resistance
    Henry Simpkins; Fiscal Year: 2007
    ..Transfection experiments showed that forced overexpression of only DDH1 induced cisplatin/carboplatin resistance in the parental cell lines...
  6. Prevention of Hip Dysplasia with Thermal Energy
    MANDI LOPEZ; Fiscal Year: 2005
    ..of thermal energy to reduce excessively lax coxofemoral joints in neonatal children and thereby help prevent DDH. The candidate of this application graduated magna cum laude from Humboldt State University with a B.S...
  7. Breast cancer and HRT: genetic susceptibility within th*
    Kathleen Malone; Fiscal Year: 2006
    ..nucleotide polymorphisms (SNPs) and tagSNPs in the PGR gene, and the following progesterone metabolizing genes, AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2, and the CYP3A4 gene...
  8. Detroit Center for Research on Oral Health Disparities
    Amid Ismail; Fiscal Year: 2007
    ..The community based partners, the City of Detroit Department of Health (DDH) and the Voices of Detroit Initiative (VODI) have strongly supported this theme...
  9. INTERPLAY OF E PROTEINS AND CYCLIN D1 DEPENDENT KINASES
    DONALD KOHTZ; Fiscal Year: 2001
    ..We have evidence that inhibition of myogenic BHLH regulators by cyclin dD1-dependent kinases is mediated by E protein dependent kase sites...
  10. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006
    ..By studying the discrete molecular events responsible for the causation of cancer this Program may lead to the early prevention and intervention of this disease. ..
  11. Symposium on Aldo-Keto Reductases & Toxicant Metabolism
    TREVOR PENNING; Fiscal Year: 2002
    ..abstract_text> ..
  12. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. Changes in Tumor DNA Methylation with Decitabine
    David Stewart; Fiscal Year: 2006
    ..This preliminary look at individual genes may provide a molecular rationale for future decitabine therapeutic studies in specific relevant tumor types. ..
  14. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 2006
    ..The contributions of beta- amino acids produced by lysine 2,3-aminomutase and arginine 2,3-aminomutase to the functions of antibiotics are not known. The beta-aminoacids may become significant in drug development. ..
  15. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 2001
    ..Finally, in Aim 4 we will assess the role of monocyte and P450 expression by Western blot and RT-PCR methods in subsets of HPBMC and human cell lines (above). ..