Gene Symbol: AKR1C1
Description: aldo-keto reductase family 1 member C1
Alias: 2-ALPHA-HSD, 20-ALPHA-HSD, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1 member C1, 20 alpha-hydroxysteroid dehydrogenase, aldo-keto reductase C, chlordecone reductase homolog HAKRC, dihydrodiol dehydrogenase 1, dihydrodiol dehydrogenase 1/2, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase isoform DD1, hepatic dihydrodiol dehydrogenase, high-affinity hepatic bile acid-binding protein, indanol dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, type II 3-alpha-hydroxysteroid dehydrogenase
Species: human
Products:     AKR1C1

Top Publications

  1. Stolz A, Hammond L, Lou H, Takikawa H, Ronk M, Shively J. cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family. J Biol Chem. 1993;268:10448-57 pubmed
    ..identified one isoform of dihydrodiol dehydrogenase activity that expresses high affinity bile acid binding (HBAB) with minimal 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) activity for bile acids...
  2. Zhang Y, Dufort I, Rheault P, Luu The V. Characterization of a human 20alpha-hydroxysteroid dehydrogenase. J Mol Endocrinol. 2000;25:221-8 pubmed
    ..The present study clearly indicates that the genuine human 20alpha-HSD belongs to the aldoketo reductase family, like the 20alpha-HSDs from other species. ..
  3. Nahoum V, Gangloff A, Legrand P, Zhu D, Cantin L, Zhorov B, et al. Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. J Biol Chem. 2001;276:42091-8 pubmed
  4. Couture J, Legrand P, Cantin L, Luu The V, Labrie F, Breton R. Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. J Mol Biol. 2003;331:593-604 pubmed
    Human 20alpha-hydroxysteroid dehydrogenase (h20alpha-HSD; AKR1C1) catalyzes the transformation of progesterone (Prog) into 20alpha-hydroxy-progesterone (20alpha-OHProg)...
  5. Hara A, Endo S, Matsunaga T, Soda M, Yashiro K, El Kabbani O. Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily. J Biochem. 2017;162:371-379 pubmed publisher
    Four human hydroxysteroid dehydrogenases in the aldo-keto reductase (AKR) superfamily, AKR1C1-AKR1C4, are involved in the metabolism of steroids and other carbonyl compounds including drugs, and altered expression of AKRs (1C1, 1C2 and/or ..
  6. Feldman G, Offemaria A, Sawan H, Parvizi J, Freeman T. A murine model for developmental dysplasia of the hip: ablation of CX3CR1 affects acetabular morphology and gait. J Transl Med. 2017;15:233 pubmed publisher
    Developmental dysplasia of the hip (DDH) is a debilitating condition whose distinguishing signs include incomplete formation of the acetabulum leading to dislocation of the femur, accelerated wear of the articular cartilage and joint ..
  7. Nio Kobayashi J, Kudo M, Sakuragi N, Iwanaga T, Duncan W. Loss of luteotropic prostaglandin E plays an important role in the regulation of luteolysis in women. Mol Hum Reprod. 2017;23:271-281 pubmed publisher
    ..01), while mRNA abundance for genes involved in PGF synthesis (AKR1B1 and AKR1C1-3) increased in the CL during the late-luteal phase and menstruation (P < 0.05-0.001)...
  8. Aserse A, Woyke T, Kyrpides N, Whitman W, Lindström K. Draft genome sequences of Bradyrhizobium shewense sp. nov. ERR11T and Bradyrhizobium yuanmingense CCBAU 10071T. Stand Genomic Sci. 2017;12:74 pubmed publisher
    ..2% ANI. Type strain ERR11T showed the highest DDH predicted value with 10.1601/strainfinder?urlappend=%3Fid%3DCCBAU+15615 (58.5%), followed by 10...
  9. Bauman B, Jeong C, Savage M, Briker A, Janigian N, Nguyen L, et al. Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation. Free Radic Biol Med. 2018;124:532-540 pubmed publisher
    ..gene expression, including expression of the cytoprotective proteins aldo-keto reductase family 1 member C1 (AKR1C1) and heme oxygenase-1 (HO-1). Additionally, sulforaphane's therapeutic window is widened by 12.5?µM dtBHQ...

More Information

Publications136 found, 100 shown here

  1. Penning T. The aldo-keto reductases (AKRs): Overview. Chem Biol Interact. 2015;234:236-46 pubmed publisher
    ..There are 15 human AKRs of these AKR1B1, AKR1C1-1C3, AKR1D1, and AKR1B10 have been implicated in diabetic complications, steroid hormone dependent malignancies, ..
  2. Mahmud Z, Asaduzzaman M, Kumar U, Masrour N, Jugov R, Coombes R, et al. Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases. Biochem Pharmacol. 2019;163:391-403 pubmed publisher
    ..Genome-wide expression profiling identified aldo-keto reductases AKR1C1-3 as effectors of stemness and drug resistance, since their pharmacological inhibition with flufenamic acid ..
  3. Antal O, Hackler L, Shen J, Mán I, Hideghéty K, Kitajka K, et al. Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: cellular, biochemical and gene expression analysis. Lipids Health Dis. 2014;13:142 pubmed publisher
    ..acids (PUFAs) and irradiation significantly changed the expression of EGR1, TNF-α, NOTCH1, c-MYC, TP53, HMOX1, AKR1C1, NQO1, while up-regulation of GADD45A, EGR1, GRP78, DDIT3, c-MYC, FOSL1 were recorded both in response to PUFA ..
  4. Poli A, Romano I, Mastascusa V, Buono L, Orlando P, Nicolaus B, et al. Vibrio coralliirubri sp. nov., a new species isolated from mucus of red coral (Corallium rubrum) collected at Procida island, Italy. Antonie Van Leeuwenhoek. 2018;111:1105-1115 pubmed publisher
    ..ANI indexes, in silico estimations of DDH values and wet lab DDH values demonstrated that strain Corallo1T represents an independent genomospecies...
  5. Colston S, Fullmer M, Beka L, Lamy B, Gogarten J, Graf J. Bioinformatic genome comparisons for taxonomic and phylogenetic assignments using Aeromonas as a test case. MBio. 2014;5:e02136 pubmed publisher
    ..standard" of bacterial species delineation is the overall genome similarity determined by DNA-DNA hybridization (DDH), a technically rigorous yet sometimes variable method that may produce inconsistent results...
  6. Hlaváč V, Brynychová V, Václavíková R, Ehrlichová M, Vrána D, Pecha V, et al. The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients. Medicine (Baltimore). 2014;93:e255 pubmed publisher
    ..AKR1A1 was significantly overexpressed and AKR1C1-4, KCNAB1, CYP2C19, CYP3A4, and CYP3A5 downregulated in tumors compared with control nonneoplastic tissues after ..
  7. Han B, Li W, Sun Y, Zhou L, Xu Y, Zhao X. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS ONE. 2014;9:e107204 pubmed publisher
    ..the expression profile results, the transcriptional and protein expression levels of candidate genes NDRG1, BNIP3, AKR1C1, CCNG2 and VEGFA were found to be significantly increased in treated KYSE 170 cells by reverse-transcription PCR ..
  8. Zapletal O, Prochazkova J, Dubec V, Hofmanova J, Kozubik A, Vondracek J. Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models. Toxicology. 2018;412:1-11 pubmed publisher
    ..with BaP, butyrate potentiated induction of cytochrome P450 family 1 enzymes (CYP1A1), aldo-keto reductases (AKR1C1) or UDP-glucuronosyltransferases (UGT1A1)...
  9. Manandhar M, Lowery M, Boulware K, Lin K, Lu Y, Wood R. Transcriptional consequences of XPA disruption in human cell lines. DNA Repair (Amst). 2017;57:76-90 pubmed publisher
    ..Only 27 common genes were different by more than 1.5-fold. The most significant hits were AKR1C1 and AKR1C2, involved in steroid hormone metabolism...
  10. MacLeod A, McMahon M, Plummer S, Higgins L, Penning T, Igarashi K, et al. Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compo. Carcinogenesis. 2009;30:1571-80 pubmed publisher
    ..0-fold. mRNA for aldo-keto reductase (AKR) 1B10, AKR1C1, AKR1C2 and AKR1C3 were induced to the greatest extent, showing increases of between 12- and 16-fold, whereas mRNA ..
  11. Kuzmanović N, Eltlbany N, Ding G, Baklawa M, Min L, Wei L, et al. Analysis of the genome sequence of plant beneficial strain Pseudomonas sp. RU47. J Biotechnol. 2018;281:183-192 pubmed publisher
    ..MLSA) coupled with the calculation of average nucleotide identity (ANI) and in silico DNA-DNA hybridization (DDH) values suggested that strain RU47 belongs to the P. koreensis group of the P...
  12. Stapelfeld C, Maser E. Sex hormones reduce NNK detoxification through inhibition of short-chain dehydrogenases/reductases and aldo-keto reductases in vitro. Chem Biol Interact. 2017;276:167-173 pubmed publisher
    ..through carbonyl reduction is catalyzed by members of the AKR- and the SDR-superfamilies which include AKR1B10, AKR1C1, AKR1C2, AKR1C4, 11?-HSD1 and CBR1...
  13. Yadav S, Vaddavalli R, Siripuram S, Eedara R, Yadav S, Rabishankar O, et al. Planctopirus hydrillae sp. nov., an antibiotic producing Planctomycete isolated from the aquatic plant Hydrilla and its whole genome shotgun sequence analysis. J Antibiot (Tokyo). 2018;71:575-583 pubmed publisher
    ..Based on whole-genome statistics, ANI value, in silico DDH, diversity of secondary metabolite biosynthetic gene clusters, distinct physiological, biochemical and ..
  14. Sheng X, Parmentier J, Tucci J, Pei H, Cortez Toledo O, Dieli Conwright C, et al. Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin. Mol Cancer Res. 2017;15:1704-1713 pubmed publisher
    ..Expression of daunorubicin-metabolizing enzymes, aldo-keto reductases (AKR1A1, AKR1B1, AKR1C1, AKR1C2, AKR1C3, and AKR7A2) and carbonyl reductases (CBR1, CBR3), in human adipose tissue, were queried using ..
  15. Lockman K, Htun V, Sinha R, Treskes P, Nelson L, Martin S, et al. Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro. Lipids Health Dis. 2016;15:114 pubmed publisher
    ..The histones depletion may represent an adaptation to increased protein synthesis. However, this can also expose DNA to oxidative stress thus should be explored further in the context of NAFLD progression. ..
  16. Ito S, Takeya M, Osanai T. Substrate Specificity and Allosteric Regulation of a D-Lactate Dehydrogenase from a Unicellular Cyanobacterium are Altered by an Amino Acid Substitution. Sci Rep. 2017;7:15052 pubmed publisher
    ..PCC 6803 can produce lactate from carbon dioxide and possesses D-lactate dehydrogenase (Ddh). Here, we performed a biochemical analysis of the Ddh from this cyanobacterium (SyDdh) using recombinant proteins...
  17. Woo S, Gao H, Henderson D, Zacharias W, Liu G, Tran Q, et al. AKR1C1 as a Biomarker for Differentiating the Biological Effects of Combustible from Non-Combustible Tobacco Products. Genes (Basel). 2017;8: pubmed publisher
    ..Notably, aldo-keto reductase genes, AKR1C1 and AKR1C2, were the core genes in the top enriched pathways and were statistically upregulated more ..
  18. Steinum T, KarataÅŸ S, Martinussen N, Meirelles P, Thompson F, Colquhoun D. Multilocus Sequence Analysis of Close Relatives Vibrio anguillarum and Vibrio ordalii. Appl Environ Microbiol. 2016;82:5496-504 pubmed publisher
    ..Taken together, MLSA and in silico DNA-DNA hybridization (DDH) calculations suggest that some isolates previously characterized as V ordalii, i.e...
  19. Loder R, Shafer C. The demographics of developmental hip dysplasia in the Midwestern United States (Indiana). J Child Orthop. 2015;9:93-8 pubmed publisher
    ..We wished to study the demographics of developmental dysplasia of the hip (DDH) in our area and compare/contrast our findings with those in the literature and specifically look for new findings ..
  20. Verbruggen S, Kainz B, Shelmerdine S, Arthurs O, Hajnal J, Rutherford M, et al. Altered biomechanical stimulation of the developing hip joint in presence of hip dysplasia risk factors. J Biomech. 2018;78:1-9 pubmed publisher
    ..Developmental dysplasia of the hip (DDH) is the most common joint shape abnormality at birth, with many risk factors for the condition being associated ..
  21. Piao S, Zhou Y, Du Y, Ma H, Sun J, Gao Z, et al. [Clinical results in early and mid term of using the S-ROM femoral stem in revision]. Zhongguo Gu Shang. 2017;30:322-328 pubmed publisher
    ..Primary THA reasons:12 cases for DDH(9 cases for Crowe IV), 5 cases for femoral neck fracture, 2 cases for necrosis of femoral head, 2 cases for ..
  22. Andrýs R, Zemanová L, Lenčo J, Bílková Z, Wsól V. Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier. Chem Biol Interact. 2015;234:169-77 pubmed publisher
    ..functionality of the presented carrier was demonstrated with pure recombinant enzymes (AKR1A1, AKR1B1, AKR1B10, AKR1C1, AKR1C2, AKR1C3, AKR1C4, CBR1 and CBR3) as well as with two model biological samples (cell extract from ..
  23. Stapelfeld C, Neumann K, Maser E. Different inhibitory potential of sex hormones on NNK detoxification in vitro: A possible explanation for gender-specific lung cancer risk. Cancer Lett. 2017;405:120-126 pubmed publisher
    ..It is mediated by different carbonyl reductases of the SDR (CBR1 and 11βHSD1) and AKR (AKR1B10, AKR1C1, AKR1C2 and AKR1C4) superfamilies...
  24. Shang H, Shih Y, Chen C, Lee M, Lu H, Chou P, et al. Laminarin Promotes Immune Responses and Normalizes Glutamic Oxaloacetic Transaminase and Glutamic Pyruvic Transaminase Levels in Leukemic Mice In Vivo. In Vivo. 2018;32:783-790 pubmed publisher
    ..5 and 5 mg/ml with ddH2O, respectively, by oral gavage every 2 days for 14 days (total of seven times)...
  25. Kaminski M, Furmanczyk E, Sobczak A, Dziembowski A, Lipinski L. Pseudomonas silesiensis sp. nov. strain A3T isolated from a biological pesticide sewage treatment plant and analysis of the complete genome sequence. Syst Appl Microbiol. 2018;41:13-22 pubmed publisher
    ..genes (16S rRNA, gyrB, rpoD and rpoB), complete genome sequence comparison (ANIb, Tetranucleotide identity, digital DDH), FAME analysis, and other biochemical tests indicate the A3T strain (type strain PCM 2856T=..
  26. Lee Y, Jeon C. Sphingobium paulinellae sp. nov. and Sphingobium algicola sp. nov., isolated from a freshwater green alga Paulinella chromatophora. Int J Syst Evol Microbiol. 2017;: pubmed publisher
    ..86?% 16S rRNA gene sequence similarity and their DNA-DNA hybridization (DDH) relatedness value was 40.6?%. Strains Pch-BT and Pch-ET were most closely related to S...
  27. Harcke H, Grissom L. Pediatric hip sonography. Diagnosis and differential diagnosis. Radiol Clin North Am. 1999;37:787-96 pubmed
    ..of pediatric hip sonography, we have reviewed pitfalls and differential diagnoses for the infant suspected of DDH and for the older child presenting with a painful hip...
  28. Gómez Garzón C, Hernández Santana A, Dussan J. Comparative genomics reveals Lysinibacillus sphaericus group comprises a novel species. BMC Genomics. 2016;17:709 pubmed publisher
    ..included whole genome alignments, searching for mobile elements, phylogenomic metrics (TETRA, ANI and in-silico DDH) and pan-genome assessments. The results support the hypothesis about this species as a very heterogeneous group...
  29. Vasilescu D, Cosma D, Vasilescu D, Botar Jid C, Gersak M, Lenghel M, et al. A new sign in the standard hip ultrasound image of the Graf method. Med Ultrason. 2015;17:206-10 pubmed publisher
    ..1078 patients (2156 hips) were included examined between 2008 and 2014 for developmental dysplasia of the hip (DDH) ultrasound screening. The patients were divided in two groups...
  30. Hareendranathan A, Mabee M, Punithakumar K, Noga M, Jaremko J. A technique for semiautomatic segmentation of echogenic structures in 3D ultrasound, applied to infant hip dysplasia. Int J Comput Assist Radiol Surg. 2016;11:31-42 pubmed publisher
    ..Quantification of the acetabular shape is crucial in diagnosing developmental dysplasia of the hip (DDH), a common condition associated with hip dislocation and premature osteoarthritis if not treated...
  31. Jennings H, Gooney M, O Beirne J, Sheahan L. Exploring the experiences of parents caring for infants with developmental dysplasia of the hip attending a dedicated clinic. Int J Orthop Trauma Nurs. 2017;25:48-53 pubmed publisher
    Specialised DDH (developmental dysplasion of the hip) clinics are developing around Ireland but are, however, variable in how they are operated...
  32. Zhen P, Liu J, Lu H, Chen H, Li X, Zhou S. Developmental hip dysplasia treated by total hip arthroplasty using a cementless Wagner cone stem in young adult patients with a small physique. BMC Musculoskelet Disord. 2017;18:192 pubmed publisher
    Developmental hip dysplasia (DDH) may lead to severe acetabular and femoral abnormalities that can render total hip arthroplasty (THA) challenging, especially in DDH patients with a small physique...
  33. Lee W, Hwang D, Noh C. Descriptive Epidemiology of Patients Undergoing Total Hip Arthroplasty in Korea with Focus on Incidence of Femoroacetabular Impingement: Single Center Study. J Korean Med Sci. 2017;32:581-586 pubmed publisher
    ..head, fracture of the femoral head or neck, ankylosing spondylitis (AS), developmental dysplasia of the hip (DDH), Legg-Calvé-Perthes disease (LCPD), FAI, and others. There were 32 patients (3...
  34. Collins Sawaragi Y, Jain K. How to use… hip examination and ultrasound in newborns?. Arch Dis Child Educ Pract Ed. 2017;: pubmed publisher
    Developmental dysplasia of the hip (DDH) ranges from a clinically detectable dislocation of the hip to radiologically diagnosed hip abnormalities. It is caused by both antenatal and postnatal factors...
  35. Nishizawa M, Nakajima T, Yasuda K, Kanzaki H, Sasaguri Y, Watanabe K, et al. Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. Genes Cells. 2000;5:111-25 pubmed
    ..BABP, PGFS and DD4 genes, which were highly homologous to the 20alpha-HSD gene, were also cloned, and their structure and function were characterized. ..
  36. Anderson L, Anderson M, Kapron A, Aoki S, Erickson J, Chrastil J, et al. The 2015 Frank Stinchfield Award: Radiographic Abnormalities Common in Senior Athletes With Well-functioning Hips but Not Associated With Osteoarthritis. Clin Orthop Relat Res. 2016;474:342-52 pubmed publisher
    ..the prevalence of radiographic findings consistent with femoroacetabular impingement (FAI) and dysplasia (DDH) in senior athletes with well-functioning hips...
  37. Haefeli P, Steppacher S, Babst D, Siebenrock K, Tannast M. An increased iliocapsularis-to-rectus-femoris ratio is suggestive for instability in borderline hips. Clin Orthop Relat Res. 2015;473:3725-34 pubmed publisher
    ..Previous studies have shown that the iliocapsularis is hypertrophied in developmental dysplasia of the hip (DDH)...
  38. Nie K, Rymaruk S, Paton R. Clicky hip alone is not a true risk factor for developmental dysplasia of the hip. Bone Joint J. 2017;99-B:1533-1536 pubmed publisher
    A clicky hip is a common referral for clinical and sonographic screening for developmental dysplasia of the hip (DDH). There is controversy regarding whether it represents a true risk factor for pathological DDH...
  39. Wang S, Davis S, Cerhan J, Hartge P, Severson R, Cozen W, et al. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Carcinogenesis. 2006;27:1828-34 pubmed
    ..Thirteen single nucleotide polymorphisms (SNPs) from 10 oxidative stress genes (AKR1A1, AKR1C1, CYBA, GPX, MPO, NOS2A, NOS3, OGG1, PPARG and SOD2) were genotyped in 1172 NHL cases and 982 population-based ..
  40. Hara A, Matsuura K, Tamada Y, Sato K, Miyabe Y, Deyashiki Y, et al. Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. Biochem J. 1996;313 ( Pt 2):373-6 pubmed
    We previously isolated three monomeric dihydrodiol dehydrogenases, DD1, DD2 and DD4, from human liver, and cloned a cDNA (C9) thought to encode DD2, which is identical with those for human bile-acid-binding protein and an oxidoreductase ..
  41. Haddad S, Lunetta K, Ruiz Narvaez E, Bensen J, Hong C, Sucheston Campbell L, et al. Hormone-related pathways and risk of breast cancer subtypes in African American women. Breast Cancer Res Treat. 2015;154:145-54 pubmed publisher
    ..The most significantly associated genes were GHRH, CALM2, CETP, and AKR1C1 for overall breast cancer (gene-based nominal p ≤ 0...
  42. Tarpada S, Girdler S, Morris M. Developmental dysplasia of the hip: a history of innovation. J Pediatr Orthop B. 2017;: pubmed publisher
    Developmental dysplasia of the hip (DDH) is a relatively common malady that has profound consequences in the infant if left untreated...
  43. Garcia Cimbrelo E. Cemented femoral stems in patients with DDH. Hip Int. 2007;17 Suppl 5:S128-33 pubmed
    ..is the procedure of choice for most adult patients with symptomatic arthrosis secondary to developmental dysplasia (DDH), but it requires complex reconstructive techniques, is usually performed in young patients, and has an increased ..
  44. Wanichwatanadecha P, Sirisrimangkorn S, Kaewprag J, Ponglikitmongkol M. Transactivation activity of human papillomavirus type 16 E6*I on aldo-keto reductase genes enhances chemoresistance in cervical cancer cells. J Gen Virol. 2012;93:1081-92 pubmed publisher
    ..Two of these genes were aldo-keto reductases (AKR1Cs), AKR1C1 and AKR1C3, which have been implicated in drug resistance...
  45. Wan K, Shanmugam R, Lee K, Saw A. Comparing the mechanical strength of hip spica cast between a conventional and a new method of application. J Child Orthop. 2016;10:387-94 pubmed publisher
    ..The new technique of application would potentially reduce the risk of cast breakage during the management of developmental dysplasia of the hip (DDH) and femur fracture in children.
  46. Maruyama M, Wakabayashi S, Ota H, Tensho K. Reconstruction of the Shallow Acetabulum With a Combination of Autologous Bulk and Impaction Bone Grafting Fixed by Cement. Clin Orthop Relat Res. 2017;475:387-395 pubmed publisher
    ..is a difficult technical problem during primary total hip arthroplasty (THA) in developmental dysplasia of the hip (DDH)...
  47. Verma A, Pal Y, Khatri I, Ojha A, Gruber Vodicka H, Schumann P, et al. Examination into the taxonomic position of Bacillus thermotolerans Yang et al., 2013, proposal for its reclassification into a new genus and species Quasibacillus thermotolerans gen. nov., comb. nov. and reclassification of B. encimensis Dastager et . Syst Appl Microbiol. 2017;40:411-422 pubmed publisher
    ..The digital DNA-DNA hybridization (DDH) and ortho average nucleotide identity (ANI) values calculated through whole genome sequences indicated that the ..
  48. Reding K, Li C, Weiss N, Chen C, Carlson C, Duggan D, et al. Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk. Am J Epidemiol. 2009;170:1241-9 pubmed publisher
    ..and 2000-2004, the authors evaluated how 51 single nucleotide polymorphisms in 7 progesterone-related genes (AKR1C1, AKR1C2, AKR1C3, CYP3A4, SRD5A1, SRD5A2, and PGR) influenced breast cancer risk...
  49. Shi H, Ren J, Xu H, Pan J, Hao X, Barlow L, et al. Upregulated expression of hITF in Crohn's disease and screening of hITF Interactant by a yeast two-hybrid system. Dig Dis Sci. 2010;55:2929-39 pubmed publisher
    ..Homo sapiens zinc finger protein 193 (ZNF193), three colonies were Homo sapiens Aldo-keto reductase family 1C 1 (AKR1C1), and one colony was of an unknown gene...
  50. Zhang Z, Zhuo Q, Chai W, Ni M, Li H, Chen J. Clinical characteristics and risk factors of periprosthetic femoral fractures associated with hip arthroplasty: A retrospective study. Medicine (Baltimore). 2016;95:e4751 pubmed publisher
    ..PFF in primary total hip arthroplasty (THA) included the diagnosis of development dysplasia of the hip (DDH) (odds ratio [OR]?=?5.01, 95%CI, 1.218-20.563, P=0.03) and CBR???0.49 (OR?=?3.34, 95%CI, 1.138-9.784, P?=?0.03)...
  51. Rasi A, Kazemian G, Khak M, Zarei R. Shortening subtrochanteric osteotomy and cup placement at true acetabulum in total hip arthroplasty of Crowe III-IV developmental dysplasia: results of midterm follow-up. Eur J Orthop Surg Traumatol. 2018;28:923-930 pubmed publisher
    The anatomic abnormalities in developmental dysplasia of hip (DDH) often make total hip replacement (THR) inevitable at a younger age. However, there is no universal gold standard technique of THR for high dislocated dysplastic hips...
  52. Li Y, Guo Y, Li M, Zhou Q, Liu Y, Chen W, et al. Acetabular index is the best predictor of late residual acetabular dysplasia after closed reduction in developmental dysplasia of the hip. Int Orthop. 2018;42:631-640 pubmed publisher
    ..was to find the best predictor of late residual acetabular dysplasia in developmental dysplasia of the hip (DDH) after closed reduction (CR) and discuss the indications for secondary surgery...
  53. Chen M, Shang X. Surgical treatment for young adult hip dysplasia: joint-preserving options. Int Orthop. 2016;40:891-900 pubmed publisher
    Developmental dysplasia of the hip (DDH) is a spectrum of disorders that results in anatomic abnormalities leading to increased contact stress in the joint and, eventually, secondary osteoarthritis...
  54. Clavé A, Tristan L, Desseaux A, Gaucher F, Lefèvre C, Stindel E. Influence of experience on intra- and inter-observer reproducibility of the Crowe, Hartofilakidis and modified Cochin classifications. Orthop Traumatol Surg Res. 2016;102:155-9 pubmed publisher
    ..whether experience influenced the reproducibility of the commonly used developmental dysplasia of the hip (DDH) classifications...
  55. Adelskov J, Patel B. A molecular phylogenetic framework for Bacillus subtilis using genome sequences and its application to Bacillus subtilis subspecies stecoris strain D7XPN1, an isolate from a commercial food-waste degrading bioreactor. 3 Biotech. 2016;6:96 pubmed publisher
    ..relationship of strains D7XPN1 and JS is also supported from our results from electronic DNA-DNA Hybridization (e-DDH) studies...
  56. Nakajima T, Yasuda K, Nishizawa M, Okada H, Yoshimura T, Ito S, et al. Expression of 20alpha-hydroxysteroid dehydrogenase mRNA in human endometrium and decidua. Endocr J. 2003;50:105-11 pubmed
    ..These results suggest that progesterone itself contributes to the regulation of local progesterone concentration through 20alpha-HSD levels in endometrial stromal cells at peri-implantation periods. ..
  57. Tafazal S, Flowers M. Do we need to follow up an early normal ultrasound with a later plain radiograph in children with a family history of developmental dysplasia of the hip?. Eur J Orthop Surg Traumatol. 2015;25:1171-5 pubmed publisher
    ..radiograph between 6 and 12 months of age for children with a family history of developmental dysplasia of hip (DDH)...
  58. Platt A, Xia Z, Liu Y, Chen G, Lazarus P. Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases. Pharmacogenet Genomics. 2016;26:370-80 pubmed publisher
    ..Human liver cytosol, CBR1, AKR1C1, AKR1C2, AKR1C3, and AKR1C4 reduce EXE to active primary metabolite 17β-DHE...
  59. Basit S, Albalawi A, Alharby E, Khoshhal K. Exome sequencing identified rare variants in genes HSPG2 and ATP2B4 in a family segregating developmental dysplasia of the hip. BMC Med Genet. 2017;18:34 pubmed publisher
    Developmental dysplasia of the hip (DDH) is a common pathological condition of the musculoskeletal system in infants which results in a congenital and developmental malformation of the hip joint...
  60. Prather H, Cheng A, Steger May K, Maheshwari V, VanDillen L. Association of Hip Radiograph Findings With Pain and Function in Patients Presenting With Low Back Pain. PM R. 2017;: pubmed publisher
    ..3%) to 33 of 45 patients (73.3%). At least one measurement of developmental hip dysplasia (DDH) was found in 7 of 60 patients (11.6%) to 11 of 63 patients (17.4%)...
  61. Fukui K, Trindade C, Briggs K, Philippon M. Arthroscopy of the hip for patients with mild to moderate developmental dysplasia of the hip and femoroacetabular impingement: Outcomes following hip arthroscopy for treatment of chondrolabral damage. Bone Joint J. 2015;97-B:1316-21 pubmed publisher
    ..was to determine patient-reported outcomes of patients with mild to moderate developmental dysplasia of the hip (DDH) and femoroacetabular impingement (FAI) undergoing arthroscopy of the hip in the treatment of chondrolabral ..
  62. Mu W, Yang D, Xu B, Mamtimin A, Guo W, Cao L. Midterm Outcome of Cementless Total Hip Arthroplasty in Crowe IV-Hartofilakidis Type III Developmental Dysplasia of the Hip. J Arthroplasty. 2016;31:668-75 pubmed publisher
    Developmental dysplasia of the hip (DDH) is widespread in developing countries, and treating Crowe IV-Hartofilakidis Type III DDH in adults requires the use of a highly demanding technique...
  63. Tikhilov R, Shubnyakov I, Burns S, Shabrov N, Kuzin A, Mazurenko A, et al. Experimental study of the installation acetabular component with uncoverage in arthroplasty patients with severe developmental hip dysplasia. Int Orthop. 2016;40:1595-1599 pubmed publisher
    ..This study provides additional guidance on optimal acetabular uncoverage assessment and fixation methods of surgeons performing THA on patients with DDH.
  64. Carsi M, Clarke N. Acetabuloplasties at Open Reduction Prevent Acetabular Dysplasia in Intentionally Delayed Developmental Dysplasia of the Hip: A Case-control Study. Clin Orthop Relat Res. 2016;474:1180-8 pubmed publisher
    ..AVN) and residual acetabular dysplasia are the two main complications of developmental dysplasia of the hip (DDH) treatment...
  65. Sahin F, Kiyan M, Karasartova D, Calgin M, Akhter S, Türegün Atasoy B. [A new method for the disruption of cell walls of gram-positive bacteria and mycobacteria on the point of nucleic acid extraction: sand method]. Mikrobiyol Bul. 2016;50:34-43 pubmed
    ..For the purpose of DNA extraction, the fine-grained sand was washed with ddH(2)O without losing small particles and then sterilized by autoclaving...
  66. Yi C, Ma C, Wang Q, Zhang G, Cao Y. Acetabular configuration and its impact on cup coverage of a subtype of Crowe type 4 DDH with bi-pseudoacetabulum. Hip Int. 2013;23:135-42 pubmed publisher
    The purpose of this study was to explore the acetabular configuration of a special subtype of Crowe type 4 DDH and its impact on cup coverage, which was identified with a particular bi-pseudoacetabulum and an inter-pseudoacetabulum spine ..
  67. Kljun J, Anko M, Traven K, Sinreih M, Pavlič R, Peršič Š, et al. Pyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents. Dalton Trans. 2016;45:11791-800 pubmed publisher
    ..Both compounds also showed a remarkable selectivity towards AKR1C1 and AKR1C3 which are targets for breast cancer drug design...
  68. de Vries S, Hadjirin N, Lay E, Zadoks R, Peacock S, Parkhill J, et al. Streptococcus bovimastitidis sp. nov., isolated from a dairy cow with mastitis. Int J Syst Evol Microbiol. 2017;: pubmed publisher
    ..rRNA and core genome phylogeny, genome-wide average nucleotide identity (ANI) and predicted DNA-DNA hybridisation (DDH) analyses...
  69. O CONNOR T, Ireland L, Harrison D, Hayes J. Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. Biochem J. 1999;343 Pt 2:487-504 pubmed
    ..aflatoxin B(1) aldehyde reductase (AKR7A2), aldehyde reductase (AKR1A1), aldose reductase (AKR1B1), dihydrodiol dehydrogenase 1 (AKR1C1) and chlordecone reductase (AKR1C4) have been expressed in Escherichia coli...
  70. Selga E, Noe V, Ciudad C. Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: role in the cell cycle and apoptosis. Biochem Pharmacol. 2008;75:414-26 pubmed
    ..The study was followed with the member AKR1C1 (EC, validating its increase in mRNA and protein levels in MTX resistant cells...
  71. Lee S, Jang W, Choi G, Lee Y, Jung H. Is the Transverse Acetabular Ligament Hypertrophied and Hindering Reduction in Developmental Dysplasia of Hip?. Arthroscopy. 2018;34:1219-1226 pubmed publisher
    ..determine whether a TAL incision is necessary for the concentric reduction of developmental dysplasia of the hip (DDH) in infants and young children...
  72. Zhao Y, Zheng X, Zhang H, Zhai J, Zhang L, Li C, et al. In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015;240:310-5 pubmed publisher
    ..Here, we report that seven sulphonylureas exhibit different in vitro inhibition towards AKR1Cs (AKR1C1, AKR1C2, AKR1C3), which are critical steroid hormone metabolism enzymes that are related to prostate cancer, ..
  73. Li Y, Li J, Li B, Wang J, Chen Y. The radiological research for pelvis asymmetry of unilateral developmental dysplasia of the hip in adult. Saudi Med J. 2016;37:1344-1349 pubmed publisher
    ..We recommend that it should be taken more cautions to use teardrops and ischial tuberosity as anatomy landmarks to balance leg-length discrepancy for unilateral DDH patients in preoperative planning and total hip arthroplasty.
  74. Blouin K, Blanchette S, Richard C, Dupont P, Luu The V, Tchernof A. Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women. Am J Physiol Endocrinol Metab. 2005;288:E398-404 pubmed
    We examined expression and activity of steroid aldoketoreductase (AKR) 1C enzymes in adipose tissue in women. AKR1C1 (20alpha-hydroxysteroid dehydrogenase; 20alpha-HSD), AKR1C2 (3alpha-HSD-3), and AKR1C3 (17beta-HSD-5) are involved mainly ..
  75. Rizner T, Smuc T, Rupreht R, Sinkovec J, Penning T. AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer. Mol Cell Endocrinol. 2006;248:126-35 pubmed
    ..We first confirmed that AKR1C1 (human 20alpha-hydroxysteroid dehydrogenase) in a cellular context inactivates P by forming 20alpha-OHP but does ..
  76. Lan Q, Zheng T, Shen M, Zhang Y, Wang S, Zahm S, et al. Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma. Hum Genet. 2007;121:161-8 pubmed
    ..in Connecticut, we analyzed one or more single nucleotide polymorphisms (SNPs) in ten candidate genes (AKR1A1, AKR1C1, AKR1C3, CYBA, GPX1, MPO, NOS2A, NOS3, OGG1, and SOD2) that mediate oxidative stress directly or indirectly in the ..
  77. Jin Y, Duan L, Lee S, Kloosterboer H, Blair I, Penning T. Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism. J Biol Chem. 2009;284:10013-22 pubmed publisher
    ..Herein we demonstrate for the first time that human AKR1C enzymes (AKR1C1-4) are able to reduce conjugated steroids such as Dht-17beta-glucuronide (DhtG), Dht-17beta-sulfate (DhtS), and ..
  78. Dora C, Leunig M, Beck M, Simovitch R, Ganz R. Acetabular dome retroversion: radiological appearance, incidence and relevance. Hip Int. 2006;16:215-22 pubmed
    Interest in acetabular version arose from the study of unstable developmental dysplastic hips (DDH). Initial studies and clinical observations described the dysplastic hip as being excessively anteverted...
  79. Matsunaga T, Arakaki M, Kamiya T, Endo S, El Kabbani O, Hara A. Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells. Chem Biol Interact. 2009;181:52-60 pubmed publisher
    ..These results suggest that AKR1C3 is a key enzyme in the initial step of 9,10-PQ-induced cytotoxicity in HAECs. ..
  80. Davies N, Hayden R, Simpson P, Birtwistle J, Mayer K, Ride J, et al. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res. 2009;69:4769-75 pubmed publisher
    ..In conclusion, we have identified AKR1C isoforms as a novel target of jasmonates in cancer cells and provide further evidence of the promise of these compounds, or derivatives thereof, as adjunctive therapies in the treatment of cancer. ..
  81. Ruiz F, Porté S, Gallego O, Moro A, Ardèvol A, del Rio Espinola A, et al. Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily. Biochem J. 2011;440:335-44 pubmed publisher
    Human AKR (aldo-keto reductase) 1C proteins (AKR1C1-AKR1C4) exhibit relevant activity with steroids, regulating hormone signalling at the pre-receptor level...
  82. Pollet V, Percy V, Prior H. Relative Risk and Incidence for Developmental Dysplasia of the Hip. J Pediatr. 2017;181:202-207 pubmed publisher
    To determine the incidence and associated risk factors of developmental dysplasia of the hip (DDH) in a modern population without universal screening...
  83. Groarke P, McLoughlin L, Whitla L, Lennon P, Curtin W, Kelly P. Retrospective Multicenter Analysis of the Accuracy of Clinical Examination by Community Physicians in Diagnosing Developmental Dysplasia of the Hip. J Pediatr. 2017;181:163-166.e1 pubmed publisher
    ..practitioners (GPs) the most common clinical findings that raised concern for developmental dysplasia of the hip (DDH) and necessitated an orthopedic outpatient referral...
  84. Kook J, Park S, Lim Y, Cho E, Jo E, Roh H, et al. Genome-Based Reclassification of Fusobacterium nucleatum Subspecies at the Species Level. Curr Microbiol. 2017;74:1137-1147 pubmed publisher
    ..nucleatum, polymorphum, vincentii, and animalis, based on DNA-DNA hybridization (DDH) patterns, phenotypic characteristics, and/or multilocus sequence analysis (MLSA)...
  85. Wang N, Zhang Y, Guan B, Zhu L, He X, Fang Q, et al. [An ultrasonographic study of the correlation between developmental dysplasia of the hip and congenital muscular torticollis in children]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:924-928 pubmed
    To investigate the significance of early screening of pediatric developmental dysplasia of the hip (DDH) and congenital muscular torticollis (CMT) using ultrasonography and establish a simultaneous screening model for pediatric DDH and ..
  86. Ma W, Zha Z, Chen K, Chen H, Wu Y, Ma J, et al. Genetic association study of common variants in TGFB1 and IL-6 with developmental dysplasia of the hip in Han Chinese population. Sci Rep. 2017;7:10287 pubmed publisher
    Developmental dysplasia of the hip (DDH) is a congenital or developmental deformation or misalignment of the hip joint that is affected by environmental and genetic factors...
  87. Kubota S, Inaba Y, Kobayashi N, Choe H, Tezuka T, Saito T. Comparison of improved range of motion between cam-type femoroacetabular impingement and borderline developmental dysplasia of the hip -evaluation by virtual osteochondroplasty using computer simulation. BMC Musculoskelet Disord. 2017;18:417 pubmed publisher
    ..FAI), it is unclear whether it should also be performed in cases of borderline developmental dysplasia of the hip (DDH) with a cam deformity...
  88. Hamada H, Takao M, Sakai T, Sugano N. Morphological variation of the anterior inferior iliac spine affects hip range of motion in flexion after rotational acetabular osteotomy. Int Orthop. 2018;42:1247-1252 pubmed publisher
    ..focused on the morphological variation of the anterior inferior iliac spine in developmental dysplasia of the hip (DDH) and its impact on post-operative bony ROM after RAO...
  89. Albers C, Rogers P, Wambeek N, Ahmad S, Yates P, Prosser G. Preoperative planning for redirective, periacetabular osteotomies. J Hip Preserv Surg. 2017;4:276-288 pubmed publisher
    ..osteotomies (PAO) represent a group of surgical procedures for treatment of developmental dysplasia of the hip (DDH) in skeletally mature and immature patients...
  90. Ji Q, Aoyama C, Nien Y, Liu P, Chen P, Chang L, et al. Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling. Cancer Res. 2004;64:7610-7 pubmed
    ..Selective loss of AKR1C1, which encodes a 20alpha-hydroxysteroid dehydrogenase [20alpha-HSD (EC 1.1.1...
  91. Colombe L, Vindrios A, Michelet J, Bernard B. Prostaglandin metabolism in human hair follicle. Exp Dermatol. 2007;16:762-9 pubmed
    ..microsomal prostaglandin E synthase-2 (mPGES-2), cytosolic prostaglandin E synthase (cPGES), the aldoketoreductase AKR1C1 and the prostaglandin F synthase AKR1C3...
  92. Glahn F, Schmidt Heck W, Zellmer S, Guthke R, Wiese J, Golka K, et al. Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors. Arch Toxicol. 2008;82:513-24 pubmed publisher
    ..response was up regulation of xenobiotic metabolising enzymes, particularly of dihydrodiol dehydrogenases 1 and 2 (AKR1C1, AKR1C2)...