AKAP9

Summary

Gene Symbol: AKAP9
Description: A-kinase anchoring protein 9
Alias: AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO, A-kinase anchor protein 9, A kinase (PRKA) anchor protein (yotiao) 9, A kinase (PRKA) anchor protein 9, A-kinase anchor protein 350 kDa, A-kinase anchor protein 450 kDa, AKAP 120-like protein, AKAP9-BRAF fusion protein, centrosome- and Golgi-localized PKN-associated protein, centrosome- and golgi-localized protein kinase N-associated protein, kinase N-associated protein, protein hyperion, protein kinase A anchoring protein 9, protein phosphatase 1, regulatory subunit 45, protein yotiao
Species: human
Products:     AKAP9

Top Publications

  1. Lin J, Wyszynski M, Madhavan R, Sealock R, Kim J, Sheng M. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J Neurosci. 1998;18:2017-27 pubmed
    ..The yeast two-hybrid screen was used here to identify yotiao, a novel coiled coil protein that interacts with NR1 in a C1 exon-dependent manner...
  2. Hurtado L, Caballero C, Gavilan M, Cardenas J, Bornens M, Rios R. Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis. J Cell Biol. 2011;193:917-33 pubmed publisher
    Mammalian cells exhibit a frequent pericentrosomal Golgi ribbon organization. In this paper, we show that two AKAP450 N-terminal fragments, both containing the Golgi-binding GM130-interacting domain of AKAP450, dissociated endogenous ..
  3. Sillibourne J, Milne D, Takahashi M, Ono Y, Meek D. Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450. J Mol Biol. 2002;322:785-97 pubmed
    ..a 182 amino acid residue fragment of the centrosomal and golgi N-kinase anchoring protein (CG-NAP, also known as AKAP450), which specifically interacts with CK1delta and CK1epsilon, but not with other CK1 isoforms...
  4. Alto N, Soderling S, Hoshi N, Langeberg L, Fayos R, Jennings P, et al. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003;100:4445-50 pubmed
    ..Thus, computer-based and peptide array screening approaches have generated a reagent that binds PKA with higher affinity than previously described AKAPs. ..
  5. El Din El Homasany B, Volkov Y, Takahashi M, Ono Y, Keryer G, Delouvee A, et al. The scaffolding protein CG-NAP/AKAP450 is a critical integrating component of the LFA-1-induced signaling complex in migratory T cells. J Immunol. 2005;175:7811-8 pubmed
    ..role of the scaffolding protein CG-NAP (centrosome and Golgi localized protein kinase N-associated protein)/AKAP450 in the process of active T cell motility induced via LFA-1 integrins...
  6. Sehrawat S, Ernandez T, Cullere X, Takahashi M, Ono Y, Komarova Y, et al. AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties. Blood. 2011;117:708-18 pubmed publisher
    ..We demonstrate that AKAP9 facilitates the microtubule polymerization rate in endothelial cells, interacts with Epac1, and is required for ..
  7. Schmidt P, Dransfield D, Claudio J, Hawley R, Trotter K, Milgram S, et al. AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes. J Biol Chem. 1999;274:3055-66 pubmed
    ..Recloning has now revealed that AKAP120 is a segment of a larger protein, AKAP350. We have now obtained a complete sequence of human gastric AKAP350 as well as partial cDNA sequences from human ..
  8. Witczak O, Skalhegg B, Keryer G, Bornens M, Tasken K, Jahnsen T, et al. Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J. 1999;18:1858-68 pubmed
    ..This cDNA clone encoded a 3908 amino acid protein of 453 kDa, that was designated AKAP450 (DDBJ/EMBL/GenBank accession No. AJ131693)...
  9. Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y. Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus. J Biol Chem. 1999;274:17267-74 pubmed

More Information

Publications107 found, 100 shown here

  1. Kim H, Takahashi M, Matsuo K, Ono Y. Recruitment of CG-NAP to the Golgi apparatus through interaction with dynein-dynactin complex. Genes Cells. 2007;12:421-34 pubmed
  2. Rivero S, Cardenas J, Bornens M, Rios R. Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130. EMBO J. 2009;28:1016-28 pubmed publisher
    We report that microtubule (MT) nucleation at the Golgi apparatus requires AKAP450, a centrosomal gamma-TuRC-interacting protein that also forms a distinct network associated with the Golgi...
  3. Robles Valero J, Martín Cófreces N, Lamana A, MacDonald S, Volkov Y, Sanchez Madrid F. Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450. Blood. 2010;115:4174-84 pubmed publisher
    ..We report a role for the scaffolding protein A-kinase anchoring protein-450 (AKAP450), a member of the A-kinase anchoring protein family, in IS formation and T-cell signaling in antigen- and ..
  4. Mir A, Agim N, Kane A, Josephs S, Park J, Ludwig K. Giant Congenital Melanocytic Nevus Treated With Trametinib. Pediatrics. 2019;143: pubmed publisher
    ..We present the case of a 7-year-old girl with a giant congenital melanocytic nevus that had an AKAP9-BRAF fusion and was treated with trametinib, which resulted in rapid resolution of the patient's lifelong, ..
  5. Song X, Ma J, Li X, Leng P, Zhou F, Li S. [Estimation of vegetation canopy water content using Hyperion hyperspectral data]. Guang Pu Xue Yu Guang Pu Fen Xi. 2013;33:2833-7 pubmed
    ..Based on the PROSAIL model, a novel model for quantitative inversion of vegetation canopy water content using Hyperion hyperspectral data was explored...
  6. Di Gioia S, Farinelli P, Letteboer S, Arsenijevic Y, Sharon D, Roepman R, et al. Interactome analysis reveals that FAM161A, deficient in recessive retinitis pigmentosa, is a component of the Golgi-centrosomal network. Hum Mol Genet. 2015;24:3359-71 pubmed publisher
    ..Notable FAM161A interactors included AKAP9, FIP3, GOLGA3, KIFC3, KLC2, PDE4DIP, NIN and TRIP11...
  7. Davidson G, Coassolo S, Kieny A, Ennen M, Pencreach E, Malouf G, et al. Dynamic Evolution of Clonal Composition and Neoantigen Landscape in Recurrent Metastatic Melanoma with a Rare Combination of Driver Mutations. J Invest Dermatol. 2019;: pubmed publisher
    ..the selected mutations are a missense mutation in MAP2K1 (F53Y) and an inversion on chromosome 7 generating a AKAP9-BRAF fusion...
  8. Rampino A, Walker R, Torrance H, Anderson S, Fazio L, Di Giorgio A, et al. Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. PLoS ONE. 2014;9:e99892 pubmed publisher
    ..Finally, the expression levels of DISC1, AKAP9, FEZ1, NDEL1 and PCM1 were compared between 63 controls and 69 schizophrenic subjects...
  9. Rios R. The centrosome-Golgi apparatus nexus. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..In this process, AKAP450 plays a central role, acting as a scaffold to recruit other centrosomal proteins important for MT generation...
  10. Kim S, Park W, Chung J. Tumour heterogeneity in triplet-paired metastatic tumour tissues in metastatic renal cell carcinoma: concordance analysis of target gene sequencing data. J Clin Pathol. 2019;72:152-156 pubmed publisher
    ..in the patients with mRCC were PTEN loss, followed by FLCN, BCR, SMARCA2, AKAP9, MLH1, MYH11, APC and TP53...
  11. Rogass C, Spengler D, Bochow M, Segl K, Lausch A, Doktor D, et al. Reduction of radiometric miscalibration--applications to pushbroom sensors. Sensors (Basel). 2011;11:6370-95 pubmed publisher
    ..Near Infrared) and Hawk SWIR (Short Wave Infrared) scenes of rural areas of the region Fichtwald in Germany and Hyperion scenes of the Jalal-Abad district in Southern Kyrgyzstan...
  12. Maltese P, Orlova N, Krasikova E, Emelyanchik E, Cheremisina A, Kuscaeva A, et al. Gene-Targeted Analysis of Clinically Diagnosed Long QT Russian Families. Int Heart J. 2017;58:81-87 pubmed publisher
    ..We identified two new mutations (KCNQ1 gene) and 6 known mutations (AKAP9, ANK2, KCNE1 and KCNJ2 genes) in 4 out of 9 probands, some of which have already been described in association ..
  13. Gavilan M, Gandolfo P, Balestra F, Arias F, Bornens M, Rios R. The dual role of the centrosome in organizing the microtubule network in interphase. EMBO Rep. 2018;19: pubmed publisher
    ..ablating one, or two, of three major mammalian γ-TuRC-binding factors namely pericentrin, CDK5Rap2, and AKAP450. Unexpectedly, we find that while all of them participate in microtubule nucleation at the Golgi apparatus, they ..
  14. Coba M, Komiyama N, Nithianantharajah J, Kopanitsa M, Indersmitten T, Skene N, et al. TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. J Neurosci. 2012;32:13987-99 pubmed publisher
    ..TNiK binds protein complexes in the synapse linking it to the NMDA receptor (NMDAR) via AKAP9. NMDAR and metabotropic receptors bidirectionally regulate TNiK phosphorylation and TNiK is required for AMPA ..
  15. van der Voort M, van Wees R, Brouwer S, van der Jagt Deutekom M, Verreault J. Forensic analysis of explosions: Inverse calculation of the charge mass. Forensic Sci Int. 2015;252:11-21 pubmed publisher
    ..Within the EU FP7 project Hyperion, TNO developed the Inverse Explosion Analysis (TNO-IEA) tool to estimate the charge mass and point of origin ..
  16. Karolczak J, Sobczak M, Skowronek K, Rędowicz M. A Kinase Anchoring Protein 9 Is a Novel Myosin VI Binding Partner That Links Myosin VI with the PKA Pathway in Myogenic Cells. Biomed Res Int. 2015;2015:816019 pubmed publisher
    ..A kinase anchoring protein 9 (AKAP9), a regulator of PKA activity, was identified by means of mass spectrometry as a possible MVI interacting partner ..
  17. Kumar N, Gupta S, Dabral S, Singh S, Sehrawat S. Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis. Mol Cell Biochem. 2017;430:115-125 pubmed publisher
    ..We report that EPAC1, PKA, and AKAP9 along with other molecular partners are amplified in breast cancer patients, indicating the importance of this ..
  18. Kumar N, Hati S, Munshi P, Sen S, Sehrawat S, Singh S. A novel spiroindoline targets cell cycle and migration via modulation of microtubule cytoskeleton. Mol Cell Biochem. 2017;429:11-21 pubmed publisher
    ..Our investigation revealed that it repositions microtubule cytoskeleton and displaces AKAP9 located at the microtubule organization centre...
  19. Wang Z, Zhang C, Qi R. A newly identified myomegalin isoform functions in Golgi microtubule organization and ER-Golgi transport. J Cell Sci. 2014;127:4904-17 pubmed publisher
    ..isoform, myomegalin variant 8 (MMG8), localized predominantly to cis-Golgi networks by interacting with AKAP450 (also known as AKAP9), and this interaction with AKAP450 was required for the stability of both proteins...
  20. Schmoker A, Barritt S, Weir M, Mann J, Hogan T, Ballif B, et al. Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A. Proteomes. 2018;6: pubmed publisher
    ..Three of these Fyn-induced PKA interactors, AKAP9, PDE4DIP, and CDK5RAP2, were validated biochemically and were shown to exist in complex with Fyn and PKA in a ..
  21. Schimenti K, Feuer S, Griffin L, Graham N, Bovet C, Hartford S, et al. AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice. Genetics. 2013;194:447-57 pubmed publisher
    ..Here we describe three alleles of the widely expressed A-kinase anchoring protein 9 (Akap9) gene, all of which cause gametogenic failure and infertility in the absence of marked somatic phenotypes...
  22. Sato Y, Hayashi K, Amano Y, Takahashi M, Yonemura S, Hayashi I, et al. MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane. Nat Commun. 2014;5:5266 pubmed publisher
    ..CLASPs and AKAP450/CG-NAP are involved in their formation, but the underlying molecular mechanisms remain unclear...
  23. Drake J, Özcan E, Burke E. A Case Study of Controlling Crossover in a Selection Hyper-heuristic Framework Using the Multidimensional Knapsack Problem. Evol Comput. 2016;24:113-41 pubmed publisher
    ..heuristics is possible in an increasing number of general-purpose hyper-heuristic tools such as HyFlex and Hyperion. However, little work has been undertaken to assess how best to utilise it...
  24. Herter J, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, et al. AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun. 2015;6:10182 pubmed publisher
    ..Here, we generate mice with a T cell-specific deletion of the scaffold protein A kinase anchoring protein 9 (AKAP9) and use models of inflammatory disease to demonstrate that AKAP9 is dispensable for T cell priming and migration ..
  25. Kendler K, Kalsi G, Holmans P, Sanders A, Aggen S, Dick D, et al. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. Alcohol Clin Exp Res. 2011;35:963-75 pubmed publisher
    ..Elegans. Genes with clusters of significant SNPs included AKAP9, phosphatidylinositol glycan anchor biosynthesis, class G (PIGG), and KCNMA1...
  26. Mason T, Goldenring J, Kolobova E. AKAP350C targets to mitochondria via a novel amphipathic alpha helical domain. Cell Logist. 2014;4:e943597 pubmed
    ..PKA is spatially regulated by A-Kinase Anchoring Proteins (AKAPs). We completed cloning of a novel AKAP350 isoform, AKAP350C. Immunostaining for endogenous AKAP350C showed localization to mitochondria...
  27. Ruppelt A, Mosenden R, Grönholm M, Aandahl E, Tobin D, Carlson C, et al. Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J Immunol. 2007;179:5159-68 pubmed
    ..Finally, small interfering RNA-mediated knockdown of Ezrin abrogates cAMP regulation of IL-2. We propose that Ezrin is essential in the assembly of the cAMP-mediated regulatory pathway that modulates T cell immune responses. ..
  28. Allegue C, Coll M, Mates J, Campuzano O, Iglesias A, Sobrino B, et al. Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome. PLoS ONE. 2015;10:e0133037 pubmed publisher
    ..Twenty-eight genes were resequenced: AKAP9, ANK2, CACNA1C, CACNB2, CASQ2, CAV3, DSC2, DSG2, DSP, GPD1L, HCN4, JUP, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ5, ..
  29. Fazil M, Ong S, Chalasani M, Low J, Kizhakeyil A, Mamidi A, et al. GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells. Sci Rep. 2016;6:37721 pubmed publisher
    ..with varying molecular weights (18?kDa Stathmin, 80?kDa PKC?, 180?kDa CD11a, 220?kDa Talin1 and 450?kDa CG-NAP/AKAP450) in human primary and cultured T-cells...
  30. Ismael H, Altmeyer S, Stahl H. Regulation of the U3-, U8-, and U13snoRNA Expression by the DEAD Box Proteins Ddx5/Ddx17 with Consequences for Cell Proliferation and Survival. Noncoding RNA. 2016;2: pubmed publisher
    ..For this reason, the 3' untranslated region of the A-kinase anchor protein 9 (AKAP9)-mRNA could be identified as a potential target.
  31. Lascarrou J, Meziani F, Le Gouge A, Boulain T, Bousser J, Belliard G, et al. Therapeutic hypothermia after nonshockable cardiac arrest: the HYPERION multicenter, randomized, controlled, assessor-blinded, superiority trial. Scand J Trauma Resusc Emerg Med. 2015;23:26 pubmed publisher
    ..The risk/benefit ratio of therapeutic hypothermia after nonshockable cardiac arrest is unclear. HYPERION is a multicenter (22 French ICUs) trial with blinded outcome assessment in which 584 patients with successfully ..
  32. Nishita M, Park S, Nishio T, Kamizaki K, Wang Z, Tamada K, et al. Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness. Sci Rep. 2017;7:1 pubmed publisher
    ..We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion...
  33. Yang X, Yu Y, Fan W. Chlorophyll content retrieval from hyperspectral remote sensing imagery. Environ Monit Assess. 2015;187:456 pubmed publisher
    ..In this study, the chlorophyll content was retrieved step by step using Hyperion imagery...
  34. Kantz S, Söhn M, Troeller A, Reiner M, Weingandt H, Alber M, et al. Impact of MLC properties and IMRT technique in meningioma and head-and-neck treatments. Radiat Oncol. 2015;10:184 pubmed publisher
    ..Consistent patient individual optimization parameters are used. Plans are generated using the research tool Hyperion V2.4 (equivalent to Elekta Monaco 3...
  35. Joestl J, Hofbauer M, Lang N, Tiefenboeck T, Hajdu S. Locking compression plate versus revision-prosthesis for Vancouver type B2 periprosthetic femoral fractures after total hip arthroplasty. Injury. 2016;47:939-43 pubmed publisher
    ..revision prosthesis (Helios), and fourteen fractures with the second-generation revision prosthesis (Hyperion). The patients were assessed clinically with the Parker mobility score and radiographically...
  36. Wang Q, Zhang J. A Data Transfer Fusion Method for Discriminating Similar Spectral Classes. Sensors (Basel). 2016;16: pubmed
    ..In order to validate the method, experiments are conducted on EO-1 Hyperion hyperspectral data and ROSIS hyperspectral data...
  37. Almada E, Tonucci F, Hidalgo F, Ferretti A, Ibarra S, Pariani A, et al. Akap350 Recruits Eb1 to The Spindle Poles, Ensuring Proper Spindle Orientation and Lumen Formation in 3d Epithelial Cell Cultures. Sci Rep. 2017;7:14894 pubmed publisher
    ..b>AKAP350 is a centrosomal/Golgi scaffold protein, implicated in the regulation of microtubule dynamics...
  38. Zhou T, Li Z, Pan J. Multi-Feature Classification of Multi-Sensor Satellite Imagery Based on Dual-Polarimetric Sentinel-1A, Landsat-8 OLI, and Hyperion Images for Urban Land-Cover Classification. Sensors (Basel). 2018;18: pubmed publisher
    ..Both Landsat-8 OLI and Hyperion images were also acquired, in combination with Sentinel-1A data, to explore the potential of different multi-..
  39. Arellano P, Tansey K, Balzter H, Boyd D. Detecting the effects of hydrocarbon pollution in the Amazon forest using hyperspectral satellite images. Environ Pollut. 2015;205:225-39 pubmed publisher
    ..In order to map this impact over wider geographical areas, vegetation indices were applied to hyperspectral Hyperion satellite imagery...
  40. Venkatesh D, Mruk D, Herter J, Cullere X, Chojnacka K, Cheng C, et al. AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function. Am J Pathol. 2016;186:270-84 pubmed publisher
    ..The large isoform of the cAMP-responsive scaffold protein AKAP9 regulates microtubule dynamics and nucleation at the Golgi...
  41. Wang H, Yeh M, Tian Y, Huang Y. Effect of Prolonged Diarrhea in Renal Transplant Recipients at a Single Center in Taiwan. Transplant Proc. 2016;48:870-3 pubmed publisher
    ..A single-center retrospective study with the use of the Hyperion data warehouse was conducted to search and evaluate for renal transplant recipients who came for medical care for ..
  42. Jansen M, Martens J, Helmijr J, Beaufort C, van Marion R, Krol N, et al. Cell-free DNA mutations as biomarkers in breast cancer patients receiving tamoxifen. Oncotarget. 2016;7:43412-43418 pubmed publisher
    ..single nucleotide variants (SNVs) for CREBBP (1 patient) and SMAD4 (1 patient) and non-synonymous SNVs for AKAP9 (1 patient), PIK3CA (2 patients) and TP53 (2 patients) were found...
  43. Zhang L, Tester D, Lang D, Chen Y, Zheng J, Gao R, et al. Does Sudden Unexplained Nocturnal Death Syndrome Remain the Autopsy-Negative Disorder: A Gross, Microscopic, and Molecular Autopsy Investigation in Southern China. Mayo Clin Proc. 2016;91:1503-1514 pubmed publisher
    ..Twelve of 44 SUNDS victims (SCN5A, SCN1B, CACNB2, CACNA1C, AKAP9, KCNQ1, KCNH2, KCNJ5, GATA4, NUP155, ABCC9) and 6 of 17 patients with BrS (SCN5A, CACNA1C; P>...
  44. Kawecki S, Kuleck G, Dorsey J, Leary C, Lum M. The prevalence of antibiotic-resistant bacteria (ARB) in waters of the Lower Ballona Creek Watershed, Los Angeles County, California. Environ Monit Assess. 2017;189:261 pubmed publisher
    ..Distributions from the environmental water samples were compared to unchlorinated secondary effluent from the Hyperion Water Reclamation Plant that was used as comparator samples likely to have an abundance of ARB...
  45. Li Y, Baldwin T, Wang Y, Subramaniam J, Carbajal A, Brand C, et al. Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction. Sci Rep. 2017;7:5522 pubmed publisher
    Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in heart. But apart from potential IKs regulation, physiological roles for AC9 are unknown...
  46. Ganly I, Ricarte Filho J, Eng S, Ghossein R, Morris L, Liang Y, et al. Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy. J Clin Endocrinol Metab. 2013;98:E962-72 pubmed publisher
    ..In addition, common oncogenic fusions of RET and NTRK1 as well as PAX8/PPAR? and AKAP9-BRAF were also assessed by RT-PCR...
  47. Yap Kannan R, Keresztes K, Hussain S, Coats T, Bown M. Infrared cameras are potential traceable "fixed points" for future thermometry studies. J Med Eng Technol. 2015;39:485-9 pubmed publisher
    ..FLIR T650sc) and a non-contact infrared temporal thermometer (Hubdic FS-700) were compared to a near blackbody (Hyperion R blackbody model 982) at 0.5 °C increments between 20-40 °C...
  48. Ikezu T, Chen C, Deleo A, Zeldich E, Fallin M, Kanaan N, et al. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018;13:254-264 pubmed publisher
    We studied the effect of two rare mutations (rs144662445 and rs149979685) in the A-kinase anchoring protein 9 (AKAP9) gene, previously associated with Alzheimer disease (AD) in African Americans (AA), on post-translational modifications ..
  49. Nishimura T, Takahashi M, Kim H, Mukai H, Ono Y. Centrosome-targeting region of CG-NAP causes centrosome amplification by recruiting cyclin E-cdk2 complex. Genes Cells. 2005;10:75-86 pubmed
  50. Cornejo Garcia J, Liou L, Blanca Lopez N, Doña I, Chen C, Chou Y, et al. Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. Pharmacogenomics. 2013;14:1857-69 pubmed publisher
    ..The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA. ..
  51. Jo Y, Kim M, Yoo N, Lee S. Frameshift Mutations of AKAP9 Gene in Gastric and Colorectal Cancers with High Microsatellite Instability. Pathol Oncol Res. 2016;22:587-92 pubmed publisher
    A-kinase-anchoring protein 9 (AKAP9) coordinates the cellular location and function of protein kinase A...
  52. Gimpel P, Lee Y, Sobota R, Calvi A, Koullourou V, Patel R, et al. Nesprin-1?-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells. Curr Biol. 2017;27:2999-3009.e9 pubmed publisher
    ..biotin identification (BioID) method [13, 14], we found several centrosomal proteins, including Akap450, Pcm1, and Pericentrin, whose association with Nesprin-1? is increased in differentiated myotubes...
  53. Ciampi R, Knauf J, Kerler R, Gandhi M, Zhu Z, Nikiforova M, et al. Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer. J Clin Invest. 2005;115:94-101 pubmed
    ..of BRAF via paracentric inversion of chromosome 7q resulting in an in-frame fusion between exons 1-8 of the AKAP9 gene and exons 9-18 of BRAF...
  54. Oshimori N, Ohsugi M, Yamamoto T. The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity. Nat Cell Biol. 2006;8:1095-101 pubmed
  55. Sanders A, Chang K, Zhu X, Thoppil R, Holmes W, Kaverina I. Nonrandom γ-TuNA-dependent spatial pattern of microtubule nucleation at the Golgi. Mol Biol Cell. 2017;28:3181-3192 pubmed publisher
    ..we have found that hotspots are significantly smaller than a Golgi subdomain positive for scaffolding protein AKAP450, which is thought to recruit GDMT nucleation factors...
  56. Kolobova E, Roland J, Lapierre L, Williams J, Mason T, Goldenring J. The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins. J Biol Chem. 2017;292:20394-20409 pubmed publisher
    ..Previous findings have suggested that AKAP350 is important for microtubule dynamics at both locations, but how this scaffolding protein assembles microtubule ..
  57. Varadarajan R, Hammer J, Rusan N. A centrosomal scaffold shows some self-control. J Biol Chem. 2017;292:20410-20411 pubmed publisher
    ..i> now identify AKAP350A's specific location and protein partners at the centrosome. The authors further define an autoregulatory mechanism that likely controls AKAP350A's ability to nucleate microtubule growth. ..
  58. Li Y, Chen L, Kass R, Dessauer C. The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart. J Biol Chem. 2012;287:29815-24 pubmed publisher
    The scaffolding protein Yotiao is a member of a large family of protein A-kinase anchoring proteins with important roles in the organization of spatial and temporal signaling...
  59. Terrin A, Monterisi S, Stangherlin A, Zoccarato A, Koschinski A, Surdo N, et al. PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome. J Cell Biol. 2012;198:607-21 pubmed publisher
    ..One such protein, AKAP9, localizes to the centrosome...
  60. Xu J, Qian W, Chen Q, Zhou Y. Calculation model of the Hyperion reflected light scattering efficiency. Appl Opt. 2017;56:5248-5252 pubmed publisher
    ..Over the range of Hyperion wavelengths, the SEA are unequal, which can be used as the characteristic signal for target classification...
  61. Tu H, Tang T, Wang Z, Bezprozvanny I. Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A. J Biol Chem. 2004;279:19375-82 pubmed
    ..1) InsP(3)R1 and PKA associate in the brain. 2) InsP(3)R1-PKA association is mediated by the AKAP9 (Yotiao) multi-functional PKA anchoring protein...
  62. Kolobova E, Efimov A, Kaverina I, Rishi A, Schrader J, Ham A, et al. Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Exp Cell Res. 2009;315:542-55 pubmed publisher
    ..Stress also caused loss of AKAP350 from the Golgi and fragmentation of the Golgi apparatus...
  63. Logue M, Schu M, Vardarajan B, Farrell J, Bennett D, Buxbaum J, et al. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimers Dement. 2014;10:609-618.e11 pubmed publisher
    ..Nominally significant (P < .05) association to AD was observed with two African-descent specific AKAP9 SNPs in tight linkage disequilibrium: rs144662445 (P = .014) and rs149979685 (P = .037)...
  64. Hu Z, Wang X, Guo W, Xie L, Huang Y, Liu Y, et al. Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells. Oncotarget. 2016;7:11733-43 pubmed publisher
    ..In the present study, we investigated the molecular mechanism by which MALAT1 enhances AKAP9 expression in CRC SW480 cells. We found that MALAT1 interacts with both SRPK1 and SRSF1...
  65. Wu J, de Heus C, Liu Q, Bouchet B, Noordstra I, Jiang K, et al. Molecular Pathway of Microtubule Organization at the Golgi Apparatus. Dev Cell. 2016;39:44-60 pubmed publisher
    ..Here, we show that CAMSAP2 stabilizes and attaches microtubule minus ends to the Golgi through a complex of AKAP450 and myomegalin. CLASPs stabilize CAMSAP2-decorated microtubules but are not required for their Golgi tethering...
  66. Perron E, Pissaloux D, Neub A, Hohl D, Tartar M, Mortier L, et al. Unclassified sclerosing malignant melanomas with AKAP9-BRAF gene fusion: a report of two cases and review of BRAF fusions in melanocytic tumors. Virchows Arch. 2018;472:469-476 pubmed publisher
    ..RNA sequencing identified in both an AKAP9-BRAF gene fusion...
  67. Truong T, Sauter W, McKay J, Hosgood H, Gallagher C, Amos C, et al. International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. Carcinogenesis. 2010;31:625-33 pubmed publisher
    ..different cancer-related pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3)...
  68. Milne R, Lorenzo Bermejo J, Burwinkel B, Malats N, Arias J, Zamora M, et al. 7q21-rs6964587 and breast cancer risk: an extended case-control study by the Breast Cancer Association Consortium. J Med Genet. 2011;48:698-702 pubmed publisher
    ..Association Consortium, the authors previously reported that the single nucleotide polymorphism 7q21-rs6964587 (AKAP9-M463I) is associated with breast cancer risk...
  69. Mattaloni S, Ferretti A, Tonucci F, Favre C, Goldenring J, Larocca M. Centrosomal AKAP350 modulates the G1/S transition. Cell Logist. 2013;3:e26331 pubmed
    b>AKAP350 (AKAP450/AKAP9/CG-NAP) is an A-kinase anchoring protein, which recruits multiple signaling proteins to the Golgi apparatus and the centrosomes...
  70. Suárez Rama J, Arrojo M, Sobrino B, Amigo J, Brenlla J, Agra S, et al. Resequencing and association analysis of coding regions at twenty candidate genes suggest a role for rare risk variation at AKAP9 and protective variation at NRXN1 in schizophrenia susceptibility. J Psychiatr Res. 2015;66-67:38-44 pubmed publisher
    ..The follow-up step based on case-only putative damaging variants revealed a promising risk variant at AKAP9. This variant, K873R, reached nominal significance after inclusion of 240 additional Spanish controls from ..
  71. Del Aguila J, Koboldt D, Black K, Chasse R, Norton J, Wilson R, et al. Alzheimer's disease: rare variants with large effect sizes. Curr Opin Genet Dev. 2015;33:49-55 pubmed publisher
    ..possible to identify novel coding variants with large effect sizes and also novel genes (TREM2, PLD3, UNC5C, and AKAP9) associated with Alzheimer's disease (AD) risk...
  72. Bouguenina H, Salaün D, Mangon A, Muller L, Baudelet E, Camoin L, et al. EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions. Proc Natl Acad Sci U S A. 2017;114:E10687-E10696 pubmed publisher
    ..isoform of myomegalin termed "SMYLE" (for short myomegalin-like EB1 binding protein), the PKA scaffolding protein AKAP9, and the pericentrosomal protein CDK5RAP2...
  73. Marx S, Kurokawa J, Reiken S, Motoike H, D ARMIENTO J, Marks A, et al. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science. 2002;295:496-9 pubmed
    ..cAMP)-dependent protein kinase (PKA) and protein phosphatase 1 (PP1) to hKCNQ1 through the targeting protein yotiao. Yotiao binds to hKCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D)...
  74. Bray J, Chennathukuzhi V, Hecht N. Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. Genomics. 2002;79:799-808 pubmed
    ..a Golgi-associated, maleenhanced autoantigen; a cDNA encoding 429 amino acids with 73% homology to centrosomal Akap9; and a cDNA encoding 346 amino acids with 75% homology to SUN1, a predicted human protein that contains a SUN ..
  75. Larocca M, Shanks R, Tian L, Nelson D, Stewart D, Goldenring J. AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus. Mol Biol Cell. 2004;15:2771-81 pubmed publisher
    The A kinase anchoring protein 350 (AKAP350) is a multiply spliced type II protein kinase A anchoring protein that localizes to the centrosomes in most cells and to the Golgi apparatus in epithelial cells...
  76. Chen L, Kurokawa J, Kass R. Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel. J Biol Chem. 2005;280:31347-52 pubmed
    ..b>Yotiao is an A-kinase-anchoring protein (AKAP) that recruits the cyclic AMP-dependent protein kinase (protein kinase A (..
  77. Rudd M, Webb E, Matakidou A, Sellick G, Williams R, Bridle H, et al. Variants in the GH-IGF axis confer susceptibility to lung cancer. Genome Res. 2006;16:693-701 pubmed
    ..37, P=5.4x10(-5)), AKAP9 M463I (OR=1.32, P=1.0x10(-4)) and GHR P495T (OR=12.98, P=0.0019)...
  78. Yang M, Hu Z, Xu C, Xie L, Wang X, Chen S, et al. MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9. Biochim Biophys Acta. 2015;1852:166-74 pubmed publisher
    ..Importantly, knockdown of AKAP-9 blocked MALAT1-mediated CRC cell proliferation, migration and invasion. These data indicate that MALAT1 may promote CRC tumor development via its target protein AKAP-9. ..
  79. Takahashi M, Mukai H, Oishi K, Isagawa T, Ono Y. Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP. J Biol Chem. 2000;275:34592-6 pubmed
    ..These results suggest that CG-NAP anchors hypophosphorylated PKCepsilon at the Golgi/centrosome area during maturation and serves as a scaffold for the phosphorylation reaction. ..
  80. Chen L, Marquardt M, Tester D, Sampson K, Ackerman M, Kass R. Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc Natl Acad Sci U S A. 2007;104:20990-5 pubmed
    ..potential duration (APD), mediated by beta-adrenergic receptor (betaAR) activation, requires assembly of AKAP9 (Yotiao) with the I(Ks) potassium channel alpha subunit (KCNQ1)...
  81. Wang Z, Wu T, Shi L, Zhang L, Zheng W, Qu J, et al. Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. J Biol Chem. 2010;285:22658-65 pubmed publisher
    ..the CM2-like motif is essential for the association of the centrosome-targeting domain to pericentrin and AKAP450. The binding with pericentrin is required for the centrosomal and Golgi localization of CDK5RAP2, whereas the ..
  82. Oldenburger A, Poppinga W, Kos F, de Bruin H, Rijks W, Heijink I, et al. A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke. Am J Physiol Cell Physiol. 2014;306:C585-97 pubmed publisher
    ..In addition, CSE reduced the protein expression of the AKAP family member AKAP9 at the cell membrane. The expression of AKAP5 and AKAP12 was unaffected by CSE...
  83. Shanks R, Larocca M, Berryman M, Edwards J, Urushidani T, Navarre J, et al. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. J Biol Chem. 2002;277:40973-80 pubmed
    b>AKAP350 can scaffold a number of protein kinases and phosphatases at the centrosome and the Golgi apparatus. We performed a yeast two-hybrid screen of a rabbit parietal cell library with a 3...
  84. Frank B, Wiestler M, Kropp S, Hemminki K, Spurdle A, Sutter C, et al. Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. J Natl Cancer Inst. 2008;100:437-42 pubmed publisher
    ..We extended the analysis of AKAP9 M463I, which is in strong linkage disequilibrium with AKAP9 N2792S, to 9523 breast cancer patients and 13770 ..
  85. Kantamneni S, Holman D, Wilkinson K, Corrêa S, Feligioni M, Ogden S, et al. GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation. J Neurochem. 2008;107:86-95 pubmed publisher
    ..These data suggest that GISP can function as a negative regulator of TSG101-dependent lysosomal degradation of transmembrane proteins in neurons to promote receptor stability. ..
  86. Kinoshita K, Komatsu T, Nishide K, Hata Y, Hisajima N, Takahashi H, et al. A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction. J Mol Cell Cardiol. 2014;72:273-80 pubmed publisher
    ..helical region of KCNQ1 that mediates subunit tetramerization, membrane trafficking, and interaction with Yotiao. This interaction is known to be required for the proper modulation of IKs by cAMP...
  87. Ohta S, Wood L, Toramoto I, Yagyu K, Fukagawa T, Earnshaw W. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. Mol Biol Cell. 2015;26:1225-37 pubmed publisher
    ..Additional data suggest that NuMA tethers microtubules at the anastral spindle poles and that augmin is required for centrosome detachment after CENP-32 depletion, possibly due to an imbalance of forces within the spindle. ..
  88. Tonucci F, Hidalgo F, Ferretti A, Almada E, Favre C, Goldenring J, et al. Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells. J Cell Sci. 2015;128:3277-89 pubmed publisher
    ..An early event in this phenomenon is the generation of a nucleus-centrosome-Golgi back-to-front axis. AKAP350 (also known as AKAP9) is a Golgi and centrosome scaffold protein that is involved in microtubule nucleation...
  89. Steadman B, Schmidt P, Shanks R, Lapierre L, Goldenring J. Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus. J Biol Chem. 2002;277:30165-76 pubmed publisher
    b>AKAP350 is a multiply spliced family of 350-450-kDa protein kinase A-anchoring proteins localized to the centrosomes and the Golgi apparatus...
  90. Fabbro M, Zhou B, Takahashi M, Sarcevic B, Lal P, Graham M, et al. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell. 2005;9:477-88 pubmed
    ..These results highlight the centrosome as a site to organize phosphorylation of Cep55, enabling it to relocate to the midbody to function in mitotic exit and cytokinesis. ..
  91. Larocca M, Jin M, Goldenring J. AKAP350 modulates microtubule dynamics. Eur J Cell Biol. 2006;85:611-9 pubmed
    b>AKAP350 is a multiply spliced type II protein kinase A-anchoring protein that localizes to the centrosomes in most cells and the Golgi apparatus in epithelial cells...