Gene Symbol: AKAP79
Description: A-kinase anchoring protein 5
Alias: AKAP75, AKAP79, H21, A-kinase anchor protein 5, A kinase (PRKA) anchor protein 5, A-kinase anchor protein 79 kDa, A-kinase anchoring protein 75/79, AKAP 79, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
Species: human
Products:     AKAP79

Top Publications

  1. Carr D, Stofko Hahn R, Fraser I, Cone R, Scott J. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. J Biol Chem. 1992;267:16816-23 pubmed
    ..A cDNA for the human RII-anchoring protein, AKAP 79, was isolated by screening an expression library with radiolabeled RII...
  2. Fraser I, Cong M, Kim J, Rollins E, Daaka Y, Lefkowitz R, et al. Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr Biol. 2000;10:409-12 pubmed
    ..Here we show that the A-kinase-anchoring protein, AKAP79/150, co-precipitates with the beta(2)-AR in cell and tissue extracts, nucleating a signaling complex that includes ..
  3. Willoughby D, Wong W, Schaack J, Scott J, Cooper D. An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J. 2006;25:2051-61 pubmed
    ..We propose that gravin-associated PDE4D isoforms provide a means to rapidly terminate subplasmalemmal cAMP signals with concomitant effects on localized ion channels or enzyme activities. ..
  4. Sik A, Gulacsi A, Lai Y, Doyle W, Pacia S, Mody I, et al. Localization of the A kinase anchoring protein AKAP79 in the human hippocampus. Eur J Neurosci. 2000;12:1155-64 pubmed
    ..In the present study, we investigated the distribution of AKAP79 in the hippocampus from postmortem human brains and lobectomy samples from patients with intractable epilepsy, ..
  5. Dart C, Leyland M. Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. J Biol Chem. 2001;276:20499-505 pubmed
    ..Here, we investigate the effect of AKAP79, a membrane-associated multivalent-anchoring protein, upon the function and modulation of the strong inwardly ..
  6. Gomez L, Alam S, Smith K, Horne E, Dell Acqua M. Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. J Neurosci. 2002;22:7027-44 pubmed
    ..synapses, the cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and calcineurin (CaN) anchoring protein AKAP79/150 is recruited to NMDA and AMPA glutamate receptors by postsynaptic density (PSD)-95 family membrane-associated ..
  7. Oliveria S, Gomez L, Dell Acqua M. Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol. 2003;160:101-12 pubmed
    ..However, direct evidence for the assembly of complexes containing PKA, CaN, AKAP79, and MAGUKs in intact cells has not been available...
  8. Willoughby D, Masada N, Wachten S, Pagano M, Halls M, Everett K, et al. AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems. J Biol Chem. 2010;285:20328-42 pubmed publisher
    ..and high resolution live cell imaging techniques, we reveal an association of the Ca(2+)-stimulable AC8 with AKAP79/150 that limits the sensitivity of AC8 to intracellular Ca(2+) events...
  9. Coghlan V, Perrino B, Howard M, Langeberg L, Hicks J, Gallatin W, et al. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science. 1995;267:108-11 pubmed
    ..is localized at postsynaptic densities by association of its regulatory subunit with an A kinase anchor protein, AKAP79. Interaction cloning experiments demonstrated that AKAP79 also binds protein phosphatase 2B, or calcineurin (CaN)...

More Information

Publications128 found, 100 shown here

  1. Kashishian A, Howard M, Loh C, Gallatin W, Hoekstra M, Lai Y. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. J Biol Chem. 1998;273:27412-9 pubmed
    ..In the case of the Ca2+/calmodulin-dependent protein phosphatase calcineurin, AKAP79 has been shown to bind calcineurin and inhibit its activity in vitro (Coghlan, V., Perrino, B. A., Howard, M...
  2. Colledge M, Dean R, Scott G, Langeberg L, Huganir R, Scott J. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron. 2000;27:107-19 pubmed
    ..a macromolecular signaling complex through direct interaction between the MAGUK proteins, PSD-95 and SAP97, and AKAP79/150. The SH3 and GK regions of the MAGUKs mediate binding to the AKAP...
  3. Michel J, Scott J. AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol. 2002;42:235-57 pubmed
    ..This review details the most recent advances in our understanding of the various biological functions dependent upon AKAP-anchored signaling complexes. ..
  4. Alto N, Soderling S, Hoshi N, Langeberg L, Fayos R, Jennings P, et al. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003;100:4445-50 pubmed
    ..Thus, computer-based and peptide array screening approaches have generated a reagent that binds PKA with higher affinity than previously described AKAPs. ..
  5. Gardner L, Tavalin S, Goehring A, Scott J, Bahouth S. AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. J Biol Chem. 2006;281:33537-53 pubmed
    ..several endogenous AKAPs were identified in HEK-293 cells, small interfering RNA-mediated down-regulation of AKAP79 prevented the recycling of the beta(1)-AR in this cell line...
  6. Bauman A, Soughayer J, Nguyen B, Willoughby D, Carnegie G, Wong W, et al. Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell. 2006;23:925-31 pubmed
    ..Here, we provide evidence for interactions between AKAP79/150 and ACV and ACVI. PKA anchoring facilitates the preferential phosphorylation of AC to inhibit cAMP synthesis...
  7. Logue J, Scott J. Organizing signal transduction through A-kinase anchoring proteins (AKAPs). FEBS J. 2010;277:4370-5 pubmed publisher
    ..Selected A-kinase anchoring protein signaling complexes are highlighted in this minireview. ..
  8. Gold M, Stengel F, Nygren P, Weisbrod C, Bruce J, Robinson C, et al. Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A. 2011;108:6426-31 pubmed publisher
    A-kinase anchoring protein 79 (AKAP79) is a human anchoring protein that organizes cAMP-dependent protein kinase (PKA), Ca(2+)/calmodulin (CaM)-dependent protein phosphatase (PP2B), and protein kinase C (PKC) for phosphoregulation of ..
  9. Alonso M, Krüger A, Sanz M, Padola N, Lucchesi P. Serotypes, virulence profiles and stx subtypes of Shigatoxigenic Escherichia coli isolated from chicken derived products. Rev Argent Microbiol. 2016;48:325-328 pubmed publisher
    ..The isolates corresponded to different serotypes and some of them, such as O22:H8, O113:H21, O130:H11, O171:H2 and O178:H19, have also been identified among STEC isolated from patients suffering from ..
  10. Bai X, Mernelius S, Jernberg C, Einemo I, Monecke S, Ehricht R, et al. Shiga Toxin-Producing Escherichia coli Infection in Jönköping County, Sweden: Occurrence and Molecular Characteristics in Correlation With Clinical Symptoms and Duration of stx Shedding. Front Cell Infect Microbiol. 2018;8:125 pubmed publisher
    ..Isolates from HUS were O104:H4 and O98: H21 serotypes...
  11. Paton A, Chen A, Wang H, McAllister L, Höggerl F, Mayr U, et al. Protection against Shiga-Toxigenic Escherichia coli by Non-Genetically Modified Organism Receptor Mimic Bacterial Ghosts. Infect Immun. 2015;83:3526-33 pubmed publisher
    ..All mice (10/10) treated with Gb3-BGs survived challenge with a highly virulent O113:H21 STEC strain and showed no pathological signs of renal injury...
  12. Imuta N, Ooka T, Seto K, Kawahara R, Koriyama T, Kojyo T, et al. Phylogenetic Analysis of Enteroaggregative Escherichia coli (EAEC) Isolates from Japan Reveals Emergence of CTX-M-14-Producing EAEC O25:H4 Clones Related to Sequence Type 131. J Clin Microbiol. 2016;54:2128-34 pubmed publisher
    ..EAEC strains were widely distributed across four major E. coli phylogroups. Strains of O111:H21/clonal group 40 (CG40) (30 strains), O126:H27/CG200 (13 strains), and O86a:H27/CG3570 (11 strains) in phylogroup B1 ..
  13. Delint Ramirez I, Willoughby D, Hammond G, Hammond G, Ayling L, Cooper D. Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8. J Biol Chem. 2011;286:32962-75 pubmed publisher
    ..Recently, AKAP79 has been reported to directly bind to adenylyl cyclase type 8 (AC8) and to regulate its responsiveness to store-..
  14. Krause M, Barth H, Schmidt H. Toxins of Locus of Enterocyte Effacement-Negative Shiga Toxin-Producing Escherichia coli. Toxins (Basel). 2018;10: pubmed publisher
    ..In particular, the LEE-negative E. coli O104:H7 German outbreak strain from 2011 and the Australian O113:H21 strain isolated from a HUS patient attracted attention...
  15. Qiu S, Zhang M, Liu Y, Guo Y, Zhao H, Song Q, et al. GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex. J Neurosci. 2014;34:13505-15 pubmed publisher
    ..Furthermore, A-kinase anchoring protein 79/150 (AKAP79/150) and PKA were translocated to the synapses after nerve injury...
  16. Samelson B, Gore B, Whiting J, Nygren P, Purkey A, Colledge M, et al. A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. J Biol Chem. 2015;290:14107-19 pubmed publisher
    ..The A-kinase anchoring protein AKAP79/150 interacts with protein kinase A (PKA), protein kinase C (PKC), and protein phosphatase 2B (calcineurin) to ..
  17. Hoshi N, Langeberg L, Gould C, Newton A, Scott J. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010;37:541-50 pubmed publisher
    A-kinase anchoring proteins (AKAPs) coordinate cell signaling events. AKAP79 brings together different combinations of enzyme binding partners to customize the regulation of effector proteins...
  18. Dias D, Caetano T, Torres R, Fonseca C, Mendo S. Shiga toxin-producing Escherichia coli in wild ungulates. Sci Total Environ. 2019;651:203-209 pubmed publisher
    ..O27:H30 was the most frequent serotype identified, followed by O146:H21 and O146:H28. Two STEC were O-untypable: ONT:H28 and ONT:H52...
  19. Kar P, Samanta K, Kramer H, Morris O, Bakowski D, Parekh A. Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1. Curr Biol. 2014;24:1361-1368 pubmed publisher
    ..signaling complex that forms after store depletion and brings calcineurin, via the scaffolding protein AKAP79, to calmodulin tethered to Orai1...
  20. Mack K, Fischer M. Disrupting sensitization of TRPV4. Neuroscience. 2017;352:1-8 pubmed publisher
    ..of interfering with normal physiology, and has prompted to explore the interaction with the scaffolding protein AKAP79, an approach successfully used for TRPV1 channels...
  21. Oderiz S, Leotta G, Galli L. [Detection and characterization of Shiga toxin-producing Escherichia coli in children treated at an inter-zonal pediatric hospital in the city of La Plata]. Rev Argent Microbiol. 2018;50:341-350 pubmed publisher
    ..The eae-negative isolates belonged to serotypes O59:H19, O102:H6, O174:NM and O174:H21. The strains O59:H19 and O174:H21 were positive for the aggR gene...
  22. Rivera Pagán A, Méndez González M, Rivera Aponte D, Malpica Nieves C, Melnik Martinez K, Zayas Santiago A, et al. A-Kinase-Anchoring Protein (AKAP150) is expressed in Astrocytes and Upregulated in Response to Ischemia. Neuroscience. 2018;384:54-63 pubmed publisher
    ..AKAP150, a rodent ortholog of human AKAP79, has been extensively studied in neurons, but very little is known about the localization and function of AKAP150 ..
  23. Ulfig N, Chan W. Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus. Neurosignals. 2002;11:95-102 pubmed
    ..To study the development of rubral afferents, the expression of A kinase anchoring protein 79 (AKAP79) and synaptophysin (SYN) was examined in the human fetal red nucleus...
  24. Richter S, Gorny X, Machts J, Behnisch G, Wustenberg T, Herbort M, et al. Effects of AKAP5 Pro100Leu genotype on working memory for emotional stimuli. PLoS ONE. 2013;8:e55613 pubmed publisher
    ..Our results suggest that AKAP5 Pro100Leu effects on emotion processing might be task-dependent with Pro homozygotes showing lower control of emotional interference, but more efficient processing of task-relevant emotional stimuli. ..
  25. Li X, Matta S, Sullivan R, Bahouth S. Carvedilol reverses cardiac insufficiency in AKAP5 knockout mice by normalizing the activities of calcineurin and CaMKII. Cardiovasc Res. 2014;104:270-9 pubmed publisher
    ..These findings identify a novel cardioprotective role for AKAP5 that is mediated by regulating the activities of cardiac CaN and CaMKII and highlight a significant role for cardiac β-ARs in this phenomenon. ..
  26. Hernandez L, Cadona J, Christensen M, Fernandez D, Padola N, Bustamante A, et al. Virulence genes and genetic diversity assessment of Shiga toxin-producing Escherichia coli O91 strains from cattle, beef and poultry products. Microb Pathog. 2018;125:463-467 pubmed publisher
    ..Twenty-two STEC O91 isolated from cattle and meat food and belonging to 5 serotypes (O91:H21, O91:H8, O91:H14, O91:H28, O91:H40) were studied...
  27. Montero D, Orellana P, Gutiérrez D, Araya D, Salazar J, Prado V, et al. Immunoproteomic analysis to identify Shiga toxin-producing Escherichia coli outer membrane proteins expressed during human infection. Infect Immun. 2014;82:4767-77 pubmed publisher
    ..antigens and immunogenic proteins, outer membrane proteins (OMPs) were extracted from STEC O26:H11, O103, O113:H21, and O157:H7 strains, and commensal E. coli strain HS was used as a control...
  28. Wu C, Zhang P, Morales C, Kiang D. Draft Whole-Genome Sequences of Three Shiga Toxin-Producing Escherichia coli O91:H21 Isolates, Two from Hemolytic Uremic Syndrome Patients and One of Porcine Origin. Genome Announc. 2014;2: pubmed publisher
    This study presents three genomes of O91:H21 isolates, two from hemolytic uremic syndrome patients and one of porcine origin...
  29. Ou S, Klempner S, Greenbowe J, Azada M, Schrock A, Ali S, et al. Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib. J Thorac Oncol. 2014;9:1821-5 pubmed publisher
    ..To date, two variants of HIP1-ALK (H21; A20) and (H28; A20) have been identified in NSCLC...
  30. Poppinga W, Heijink I, Holtzer L, Skroblin P, Klussmann E, Halayko A, et al. A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015;308:L766-75 pubmed publisher
  31. Liu H, Xiong Y, Liu X, Li J. Complete genome sequence of a novel virulent phage ST31 infecting Escherichia coli H21. Arch Virol. 2018;163:1993-1996 pubmed publisher
    ..Phage ST31 infecting Escherichia coli H21 was isolated from wastewater and sequenced using an Illumina Hiseq system...
  32. Atencia M, Toro Cantillo A, Hoyos López R. [Diversidad genética y estructura poblacional de Anopheles triannulatus s.l. en Córdoba, Colombia, determinadas mediante el método de región de código de barras de ADN]. Biomedica. 2018;38:117-126 pubmed publisher
    ..Los haplotipos H2 y H21 fueron los más frecuentes en las poblaciones...
  33. Zhang J, Shapiro M. Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve. J Physiol. 2016;594:31-7 pubmed publisher
    ..With the extensive studies of AKAP79/150 in regulation of ion channel activity, the major questions to be posed centre on the mechanism and functional ..
  34. Kay H, Greene D, Kang S, Kosenko A, Hoshi N. M-current preservation contributes to anticonvulsant effects of valproic acid. J Clin Invest. 2015;125:3904-14 pubmed publisher
    ..VPA treatment interferes with M-channel signaling by inhibiting palmitoylation of a signaling scaffold protein, AKAP79/150, in cultured neurons...
  35. Nüesch Inderbinen M, Morach M, Cernela N, Althaus D, Jost M, Mäusezahl M, et al. Serotypes and virulence profiles of Shiga toxin-producing Escherichia coli strains isolated during 2017 from human infections in Switzerland. Int J Med Microbiol. 2018;308:933-939 pubmed publisher
    ..5% of the stx positive samples. STEC O157:H7 accounted for 7.5% of all isolates, and STEC O80:H2, O91:H10/H14/H21, O103:H2/H11, and O26:H11 accounted for 36.9% of the non-O157 strains...
  36. Quiñones B, Yambao J, Lee B. Draft Genome Sequences of Escherichia coli O113:H21 Strains Recovered from a Major Produce Production Region in California. Genome Announc. 2017;5: pubmed publisher
    ..This report documents the draft genome sequences of seven O113:H21 strains recovered from livestock, wildlife, and soil samples recovered from a major agricultural region for leafy ..
  37. Shridhar P, Patel I, Gangiredla J, Noll L, Shi X, Bai J, et al. DNA microarray-based assessment of virulence potential of Shiga toxin gene-carrying Escherichia coli O104:H7 isolated from feedlot cattle feces. PLoS ONE. 2018;13:e0196490 pubmed publisher
    ..and compare them to the human strains (clinical) of O104:H7, STEC O104:H4 (German outbreak strain), and O104:H21 (milk-associated Montana outbreak strain)...
  38. Xu F, Lu C, Wu Q, Chen J, Gu W, Du W, et al. Study on antitumor molecular mechanism of Alisols based on p53DNA. Int J Biol Macromol. 2018;116:1163-1174 pubmed publisher
    ..sites for the interaction between alisol monomers and p53DNA include C19-OH and C22-OH of the alisols; N2 and H21 of the guanine deoxynucleotide (DG8), N2-H21 of the DG7, O4' of the DG9 in the f-chain of p53DNA; and C2-O2 of the ..
  39. Lu Y, Zha X, Kim E, Schachtele S, Dailey M, Hall D, et al. A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density. J Biol Chem. 2011;286:26496-506 pubmed publisher
    ..However, synaptic transmission and spine density was normal at 8 weeks in KO and D36 mice. Thus AKAP150-independent mechanisms correct the aberrantly high number of active spines in juvenile AKAP150 KO and D36 mice during development. ..
  40. Yan X, Fratamico P, Bono J, Baranzoni G, Chen C. Genome sequencing and comparative genomics provides insights on the evolutionary dynamics and pathogenic potential of different H-serotypes of Shiga toxin-producing Escherichia coli O104. BMC Microbiol. 2015;15:83 pubmed publisher
    Various H-serotypes of the Shiga toxin-producing Escherichia coli (STEC) O104, including H4, H7, H21, and H¯, have been associated with sporadic cases of illness and have caused food-borne outbreaks globally. In the U.S...
  41. Tsutsuki H, Yahiro K, Ogura K, Ichimura K, Iyoda S, Ohnishi M, et al. Subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli induces stress granule formation. Cell Microbiol. 2016;18:1024-40 pubmed publisher
    ..The culture supernatant of STEC O113:H21 dramatically induced SG in Caco2 cells, although subAB knockout STEC O113:H21 culture supernatant did not...
  42. Bando S, Iamashita P, Guth B, Dos Santos L, Fujita A, Abe C, et al. A hemolytic-uremic syndrome-associated strain O113:H21 Shiga toxin-producing Escherichia coli specifically expresses a transcriptional module containing dicA and is related to gene network dysregulation in Caco-2 cells. PLoS ONE. 2017;12:e0189613 pubmed publisher
    Shiga toxin-producing (Stx) Escherichia coli (STEC) O113:H21 strains are associated with human diarrhea and some of these strains may cause hemolytic uremic syndrome (HUS)...
  43. Miyake Y, Keusch J, Wang L, Saito M, Hess D, Wang X, et al. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol. 2016;12:748-54 pubmed publisher
    ..We identified a uniquely positioned ?-helix and a flexible tryptophan residue in the loop joining ?-helices H20 to H21 as critical for deacetylation of the physiologic substrate tubulin...
  44. Lensen M, Nolte R, Rowan A, Pyckhout Hintzen W, Feiters M, Elemans J. Self-assembly of porphyrin hexamers via bidentate metal-ligand coordination. Dalton Trans. 2018;47:14277-14287 pubmed publisher
    ..In contrast, the metal-free hexamer H21 did not form extended assemblies due to the absence of coordinative intermolecular interactions.
  45. Woolfrey K, Sanderson J, Dell Acqua M. The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150. J Neurosci. 2015;35:442-56 pubmed publisher
    ..we report that the recycling endosome-resident palmitoyl acyltransferase DHHC2 interacts with and palmitoylates AKAP79/150 to regulate these plasticity signaling mechanisms...
  46. Martins F, Guth B, Piazza R, Elias W, Leão S, Marzoa J, et al. Lambs are an important source of atypical enteropathogenic Escherichia coli in southern Brazil. Vet Microbiol. 2016;196:72-77 pubmed publisher
    ..Of the 11 serotypes identified, eight were described among human pathogenic strains, while three (O1:H8, O11:H21 and O125:H19) were not previously detected in aEPEC...
  47. Musheshe N, Lobo M, Schmidt M, Zaccolo M. Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79. Sensors (Basel). 2018;18: pubmed publisher
    ..Here, we investigate the effects of using the A-kinase anchoring protein 79 (AKAP79) as a targeting domain for cAMP and PKA FRET-based reporters...
  48. Penny C, Gold M. Mechanisms for localising calcineurin and CaMKII in dendritic spines. Cell Signal. 2018;49:46-58 pubmed publisher
    ..describe the structural basis of calcineurin and CaMKII localisation by their interaction with proteins including AKAP79, densin-180, ?-actinin, and NMDARs...
  49. Lin L, Sun W, Kung F, Dell Acqua M, Hoffman D. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking. J Neurosci. 2011;31:1323-32 pubmed publisher
    ..As part of a previous study, we showed that AKAP79/150 interacts with Kv4.2 complexes and that the two proteins colocalize in hippocampal neurons...
  50. Diering G, Gustina A, Huganir R. PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity. Neuron. 2014;84:790-805 pubmed publisher
    ..Finally, we show that AMPARs scale differentially based on their phosphorylation status at S845. These results show that rearrangement in PKA signaling controls AMPAR phosphorylation and surface targeting during homeostatic plasticity. ..
  51. Bolligarla R, Ishida M, Shetti V, Yamasumi K, Furuta H, Lee C. Intramolecular charge transfer character in tetrathiafulvalene-annulated porphyrinoids: effects of core modification and protonation. Phys Chem Chem Phys. 2015;17:8699-705 pubmed publisher
    ..The pronounced electron accepting ability of the macrocyclic core of the dicationic species (H21(2+) and H22(2+)) resulted in the thermally excited electron transfer occurring at room temperature as elucidated by ..
  52. Smith F, Esseltine J, Nygren P, Veesler D, Byrne D, Vonderach M, et al. Local protein kinase A action proceeds through intact holoenzymes. Science. 2017;356:1288-1293 pubmed publisher
    ..Single-particle electron microscopy demonstrated that AKAP79 constrains RII-C subassemblies within 150 to 250 angstroms of its targets...
  53. Thompson J, Shuttleworth T. Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel. J Physiol. 2015;593:559-72 pubmed publisher
    ..residue by protein kinase A is mediated by the association of plasma membrane STIM1 with the scaffolding protein AKAP79. Together, these findings indicate that the phosphorylation status of this single residue in STIM1 represents a ..
  54. Álvarez Suárez M, Otero A, García López M, Dahbi G, Blanco M, Mora A, et al. Genetic characterization of Shiga toxin-producing Escherichia coli (STEC) and atypical enteropathogenic Escherichia coli (EPEC) isolates from goat's milk and goat farm environment. Int J Food Microbiol. 2016;236:148-54 pubmed publisher
    ..Another seven STEC strains were of serotype O146:H21 and three of serotype O166:H28, also linked to human disease...
  55. Guinzberg R, Díaz Cruz A, Acosta Trujillo C, Vilchis Landeros M, Vázquez Meza H, Lozano Flores C, et al. Newly synthesized cAMP is integrated at a membrane protein complex signalosome to ensure receptor response specificity. FEBS J. 2017;284:258-276 pubmed publisher
    ..A2A -Ado-GPCR selective stimulation activates adenylyl cyclase 6 (AC6), which is bound to AKAP79/150, to synthesize cAMP which is used by two other AKAP79/150-tethered proteins: protein kinase A (PKA) and ..
  56. Feng P, Delannoy S, Lacher D, Bosilevac J, Fach P, Beutin L. Shiga Toxin-Producing Serogroup O91 Escherichia coli Strains Isolated from Food and Environmental Samples. Appl Environ Microbiol. 2017;83: pubmed publisher
    Shiga toxin-producing Escherichia coli (STEC) strains of the O91:H21 serotype have caused severe infections, including hemolytic-uremic syndrome...
  57. Li X, Nooh M, Bahouth S. Role of AKAP79/150 protein in ?1-adrenergic receptor trafficking and signaling in mammalian cells. J Biol Chem. 2013;288:33797-812 pubmed publisher
    ..We examined the role of AKAP79/150 (AKAP5) in trafficking and signaling of the ?1-adrenergic receptor (?1-AR)...
  58. Authement M, Kodangattil J, Gouty S, Rusnak M, Symes A, Cox B, et al. Histone Deacetylase Inhibition Rescues Maternal Deprivation-Induced GABAergic Metaplasticity through Restoration of AKAP Signaling. Neuron. 2015;86:1240-52 pubmed publisher
    ..VTA DA neurons through epigenetic modifications of postsynaptic scaffolding A-kinase anchoring protein 79/150 (AKAP79/150) signaling...
  59. Seyler C, Scherer D, Köpple C, Kulzer M, Korkmaz S, Xynogalos P, et al. Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:493-503 pubmed publisher
    ..We observed functional and spatial coupling of the plasma membrane-associated AKAP15 and AKAP79 to Kir2.1 and Kir2.2 channel subunits, but not to Kir2.3 channels...
  60. Nikandrova Y, Jiao Y, Baucum A, Tavalin S, Colbran R. Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activ. J Biol Chem. 2010;285:923-34 pubmed publisher
    ..complexes coordinated by synapse-associated protein 97 (SAP97) that contain A-kinase anchoring protein 79/150 (AKAP79/150), protein kinase A, and protein phosphatase 2B...
  61. Han C, Tomita H, Ohba T, Nishizaki K, Ogata Y, Matsuzaki Y, et al. Modified sympathetic nerve regulation in AKAP5-null mice. Biochem Biophys Res Commun. 2016;469:897-902 pubmed publisher
    ..AKAP5, also known as AKAP79/150, is an anchoring protein between PKA and voltage-dependent calcium channels, ryanodine receptor-2, ..
  62. Zhao C, Höppner A, Xu Q, Gartner W, Scheer H, Zhou M, et al. Structures and enzymatic mechanisms of phycobiliprotein lyases CpcE/F and PecE/F. Proc Natl Acad Sci U S A. 2017;114:13170-13175 pubmed publisher
    ..motif critical for the isomerase activity of PecE/F is located at the loop between h20 and h21, supporting the proposal that the nucleophilic addition of Cys-88 to C10 of phycocyanobilin induces the ..
  63. Seyahian E, Oltra G, Ochoa F, Melendi S, Hermes R, Paton J, et al. Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21. Toxicon. 2017;127:49-55 pubmed publisher
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    ..proteins in differentiated cells and the expression and activation of key cAMP players such as EPAC, PKA and AKAP79/150...
  65. González de Valdivia E, Broselid S, Kahn R, Olde B, Leeb Lundberg L. G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms. J Biol Chem. 2017;292:9932-9943 pubmed publisher
    ..Based on these results, we propose that GPR30 increases ERK1/2 activity via two Gi/o-mediated mechanisms, a PDZ-dependent, apparently constitutive mechanism and a PDZ-independent G-1-stimulated mechanism. ..
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    ..Fifty (47·6%) strains belonged to nine serotypes (O8:H19, O22:H8, O22:H16, O74:H42, O113:H21, O141:H21, O157:H7, O171:H2 and ONT:H21)...
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    ..Sod1 (T2.5h median H60: 1.01, H21: 0.88, p = 0.005; T5h median H60: 1.04, H21: 0.85, p = 0.038) and Il1b (T0h median H60: 0.86, H21: 1.08, p = 0...
  68. Cong W, Meng X, Li J, Zhang Q, Chen F, Liu W, et al. Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort. BMC Genomics. 2017;18:421 pubmed publisher
    ..g., functional interaction among the protein products of these genes) and suggest high confidence candidates for subsequent analyses. ..
  69. Balière C, Rincé A, Delannoy S, Fach P, Gourmelon M. Molecular Profiling of Shiga Toxin-Producing Escherichia coli and Enteropathogenic E. coli Strains Isolated from French Coastal Environments. Appl Environ Microbiol. 2016;82:3913-3927 pubmed publisher
    ..One O91:H21 STEC strain containing 4 stx variants (stx1a, stx2a, stx2c, and stx2d) was found to possess genes associated with ..
  70. Zhang J, Carver C, Choveau F, Shapiro M. Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron. 2016;92:461-478 pubmed publisher
    ..complexes containing diverse channel types at the single-complex level in sensory neurons, dependent on AKAP79/150. Electrophysiological studies revealed that such ion channels are functionally coupled as well...
  71. Salaun C, Ritchie L, Greaves J, Bushell T, Chamberlain L. The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells. Mol Cell Neurosci. 2017;85:235-246 pubmed publisher
    The S-acyltransferase zDHHC2 mediates dynamic S-acylation of PSD95 and AKAP79/150, which impacts synaptic targeting of AMPA receptors...
  72. Omelchenko A, Firestein B. Lipids and phosphates at odds in synaptic depression. J Biol Chem. 2018;293:1568-1569 pubmed publisher
    ..of in vitro biochemical assays to provide evidence that synaptic removal of the scaffolding protein AKAP79/150 promotes LTD-induced spine shrinkage...
  73. Hauser E, Bruederle M, Reich C, Bruckbauer A, Funk J, Schmidt H. Subtilase contributes to the cytotoxicity of a Shiga toxin-producing Escherichia coli strain encoding three different toxins. Int J Food Microbiol. 2016;217:156-61 pubmed publisher
    Food-borne Shiga toxin-producing Escherichia coli (STEC) O113:H21 strain TS18/08, that has previously been isolated from mixed minced meat, harbors the Shiga toxin (Stx) encoding allele stx2a, the plasmid-located subtilase cytotoxin ..
  74. Cundon C, Carbonari C, Zolezzi G, Rivas M, Bentancor A. Putative virulence factors and clonal relationship of O174 Shiga toxin-producing Escherichia coli isolated from human, food and animal sources. Vet Microbiol. 2018;215:29-34 pubmed publisher
    ..The aim of this study was to characterize 41 O174:[H21, H28] STEC strains isolated from animals, food, and humans...
  75. Fukuda T, Kiuchi K, Takahashi M. Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase. J Biol Chem. 2002;277:19114-21 pubmed
    ..These findings propose a novel mechanism that receptor tyrosine kinase modulates actin dynamics in neuronal cells via its cAMP-dependent phosphorylation. ..
  76. Ruppelt A, Mosenden R, Grönholm M, Aandahl E, Tobin D, Carlson C, et al. Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J Immunol. 2007;179:5159-68 pubmed
    ..Finally, small interfering RNA-mediated knockdown of Ezrin abrogates cAMP regulation of IL-2. We propose that Ezrin is essential in the assembly of the cAMP-mediated regulatory pathway that modulates T cell immune responses. ..
  77. Alonso C, Mora A, Díaz D, Blanco M, González Barrio D, Ruiz Fons F, et al. Occurrence and characterization of stx and/or eae-positive Escherichia coli isolated from wildlife, including a typical EPEC strain from a wild boar. Vet Microbiol. 2017;207:69-73 pubmed publisher
    ..Nine STEC showed seropathotypes B (O145:[H28]) and C (O22:H8, O128:[H2]) associated with HUS, and D (O110:H28, O146:H21, O146:[H28], ONT:H8) associated with human diarrhea...
  78. Xie G, Raufman J. Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1051-8 pubmed
    ..In Western blots, we identified AKAP150, a rodent homologue of human AKAP79 that coimmunoprecipitates with PKA, PKC, and actin...
  79. Correia S, Bassani S, Brown T, Lise M, Backos D, El Husseini A, et al. Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. Nat Neurosci. 2008;11:457-66 pubmed publisher
    ..In summary, we identified the specific motor protein and organelle acceptor that catalyze the directional transport of AMPARs into spines during activity-dependent synaptic plasticity. ..
  80. Keith D, Sanderson J, Gibson E, Woolfrey K, Robertson H, Olszewski K, et al. Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms. J Neurosci. 2012;32:7119-36 pubmed publisher
    ..The A-kinase anchoring protein 79/150 (AKAP79/150) signaling scaffold regulates AMPAR phosphorylation, channel activity, and endosomal trafficking associated ..
  81. Btesh J, Fischer M, Stott K, McNaughton P. Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia. J Neurosci. 2013;33:9184-9193 pubmed publisher
    ..kinases that phosphorylate TRPV1, a process that has recently been shown to rely on a scaffolding protein, AKAP79, to target the kinases to TRPV1...
  82. Broselid S, Berg K, Chavera T, Kahn R, Clarke W, Olde B, et al. G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production. J Biol Chem. 2014;289:22117-27 pubmed publisher
  83. Gaaz T, Sulong A, Kadhum A, Nassir M, Al Amiery A. Impact of Sulfuric Acid Treatment of Halloysite on Physico-Chemic Property Modification. Materials (Basel). 2016;9: pubmed publisher
    ..investigated when HNT is exposed to sulfuric acid with treatment periods of 1 h (H1), 3 h (H3), 8 h (H8), and 21 h (H21)...
  84. Nygren P, Mehta S, Schweppe D, Langeberg L, Whiting J, Weisbrod C, et al. Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. elife. 2017;6: pubmed publisher
    ..Conformational flexibility in regions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B access to phosphoproteins...
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    ..In addition, multivalent binding proteins such as AKAP79 and AKAP250 have been characterized and appear to serve as platforms for the assembly of kinase/phosphatase ..
  86. Tavalin S. AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site. J Biol Chem. 2008;283:11445-52 pubmed publisher
    ..The multivalent neuronal scaffold A-kinase-anchoring protein 79 (AKAP79) is known to bind PKC and is linked to GluR1 by synapse-associated protein 97 (SAP97)...
  87. Chen M, Malbon C. G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential trafficking and distribution. Cell Signal. 2009;21:136-42 pubmed publisher
    ..Thus these homologous, AKAPs that dock G-protein-coupled receptors have markedly different patterns of trafficking, docking, and re-distribution. ..
  88. Brooks I, Tavalin S. Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors. J Biol Chem. 2011;286:6697-706 pubmed publisher
    ..By directing PKC to GluA1, A-kinase anchoring protein 79 (AKAP79) facilitates Ser-831 phosphorylation and makes PKC a more potent regulator of GluA1 than CaMKII...
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    ..Using a combination of western blotting and immuno-cytochemistry, we illustrate the presence of AKAP149, AKAP79, Ezrin and the regulatory subunits of PKA in DC lipid rafts...
  90. Shen J, Cooper D. AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex. Biochem J. 2013;455:47-56 pubmed publisher
    ..We reveal that, upon agonist binding to the Gq-coupled muscarinic receptor, AKAP79 (A-kinase-anchoring protein 79) recruits PKC to activate AC2 to produce cAMP...
  91. Carr D, Hausken Z, Fraser I, Stofko Hahn R, Scott J. Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J Biol Chem. 1992;267:13376-82 pubmed
    ..The nanomolar affinity constant and the different patterns of RII-anchoring proteins in each tissue suggest that the type II alpha PKA holoenzyme may be specifically targeted to different locations in each type of cell. ..
  92. Hirsch A, Glantz S, Li Y, You Y, Rubin C. Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta. J Biol Chem. 1992;267:2131-4 pubmed