Gene Symbol: AKAP13
Description: A-kinase anchoring protein 13
Alias: AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47, A-kinase anchor protein 13, A kinase (PRKA) anchor protein 13, LBC oncogene, breast cancer nuclear receptor-binding auxiliary protein, guanine nucleotide exchange factor Lbc, human thyroid-anchoring protein 31, lymphoid blast crisis oncogene, non-oncogenic Rho GTPase-specific GTP exchange factor, protein kinase A-anchoring protein 13
Species: human
Products:     AKAP13

Top Publications

  1. Toksoz D, Williams D. Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. Oncogene. 1994;9:621-8 pubmed
    ..These data indicate that the lbc oncogene encodes a novel product implicated in distinct cellular signal transduction functions.
  2. Diviani D, Soderling J, Scott J. AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. J Biol Chem. 2001;276:44247-57 pubmed
    ..We now demonstrate that a longer transcript of the Lbc gene encodes a chimeric molecule, which we have called AKAP-Lbc, that functions as an A-kinase-anchoring protein (..
  3. Sugawara M, Whittaker S, Bishop S, Ball L, Overduin M. Resonance assignments of the human AKAP13-PH domain and stabilizing DH helix. Biomol NMR Assign. 2009;3:215-8 pubmed publisher
    The human AKAP13 protein contains DH and PH domains, which are responsible for its cell transforming activity...
  4. Sterpetti P, Hack A, Bashar M, Park B, Cheng S, Knoll J, et al. Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting. Mol Cell Biol. 1999;19:1334-45 pubmed
    The human lbc oncogene product is a guanine nucleotide exchange factor that specifically activates the Rho small GTP binding protein, thus resulting in biologically active, GTP-bound Rho, which in turn mediates actin cytoskeletal ..
  5. Klussmann E, Edemir B, Pepperle B, Tamma G, Henn V, Klauschenz E, et al. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. FEBS Lett. 2001;507:264-8 pubmed
    ..proteins (AKAPs) involved in vasopressin-mediated water reabsorbtion, the complete sequence of the human AKAP Ht31 was determined and a partial cDNA of its rat orthologue (Rt31) was cloned...
  6. Carnegie G, Smith F, McConnachie G, Langeberg L, Scott J. AKAP-Lbc nucleates a protein kinase D activation scaffold. Mol Cell. 2004;15:889-99 pubmed
    ..In this report we demonstrate that the A-kinase anchoring protein AKAP-Lbc assembles an activation complex for the lipid-dependent enzyme protein kinase D (PKD)...
  7. Baisamy L, Jurisch N, Diviani D. Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc. J Biol Chem. 2005;280:15405-12 pubmed
    AKAP-Lbc is a novel member of the A-kinase anchoring protein (AKAPs) family, which functions as a cAMP-dependent protein kinase (PKA)-targeting protein as well as a guanine nucleotide exchange factor (GEF) for RhoA...
  8. Del Vescovo C, Cotecchia S, Diviani D. A-kinase-anchoring protein-Lbc anchors I?B kinase ? to support interleukin-6-mediated cardiomyocyte hypertrophy. Mol Cell Biol. 2013;33:14-27 pubmed publisher
    ..In this study, we show that A-kinase-anchoring protein (AKAP)-Lbc and the inhibitor of NF-?B kinase subunit ? (IKK?) form a transduction complex in cardiomyocytes that controls the ..
  9. Wirtenberger M, Tchatchou S, Hemminki K, Klaes R, Schmutzler R, Bermejo J, et al. Association of genetic variants in the Rho guanine nucleotide exchange factor AKAP13 with familial breast cancer. Carcinogenesis. 2006;27:593-8 pubmed
    The A-kinase anchor protein 13 (AKAP13, alias BRX and lbc) tethers cAMP-dependent protein kinase to its subcellular environment and catalyses Rho GTPases activity as a guanine nucleotide exchange factor...

More Information

Publications114 found, 100 shown here

  1. Smith F, Langeberg L, Cellurale C, Pawson T, Morrison D, Davis R, et al. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol. 2010;12:1242-9 pubmed publisher
    ..We demonstrate that the A-kinase-anchoring protein AKAP-Lbc and the scaffolding protein kinase suppressor of Ras (KSR-1) form the core of a signalling network that efficiently ..
  2. Cariolato L, Cavin S, Diviani D. A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation. J Biol Chem. 2011;286:7925-37 pubmed publisher
    ..Here, we show that AKAP-Lbc, an A-kinase anchoring protein (AKAP) with an intrinsic Rho-specific guanine nucleotide exchange factor activity, ..
  3. Edwards H, Scott J, Baillie G. The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16). Biochem J. 2012;446:437-43 pubmed publisher
    ..Biochemical and immunofluorescence techniques identify the cytosolic protein AKAP-Lbc (AKAP13) as the anchoring protein responsible for directing PKA phosphorylation of Hsp20 on Ser(16)...
  4. Diviani D, Abuin L, Cotecchia S, Pansier L. Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J. 2004;23:2811-20 pubmed
    ..We recently identified a novel anchoring protein, called AKAP-Lbc, which functions as a PKA-targeting protein as well as a guanine nucleotide exchange factor (GEF) for RhoA...
  5. Hu J, Wang L, Li Y, Yang K, Zhang P, Chen X, et al. The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer. Clin Exp Med. 2010;10:41-9 pubmed publisher
    There was no literature reporting the relationship between AKAP13 and colorectal carcinoma. This study is aim to investigate the expression and role of AKAP13 in human colorectal cancers...
  6. Burmeister B, Taglieri D, Wang L, Carnegie G. Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart. J Biol Chem. 2012;287:40535-46 pubmed publisher
    AKAP-Lbc is a scaffold protein that coordinates cardiac hypertrophic signaling. AKAP-Lbc interacts with Shp2, facilitating its regulation by PKA. AKAP-Lbc integrates PKA and Shp2 signaling in the heart...
  7. Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, et al. Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. Oncogene. 1998;16:2513-26 pubmed
    ..protein, Brx, that contains a region of identity to the oncogenic Rho-guanine nucleotide exchange (Rho-GEF) protein Lbc, and a unique region capable of binding to nuclear hormone receptors, including the ER...
  8. Bear M, Li M, Liu Y, Giel Moloney M, Fanburg B, Toksoz D. The Lbc Rho guanine nucleotide exchange factor α-catulin axis functions in serotonin-induced vascular smooth muscle cell mitogenesis and RhoA/ROCK activation. J Biol Chem. 2010;285:32919-26 pubmed publisher
    ..extracellular signals to Rho, and we found that 5-HT treatment of PASMC led to increased membrane-associated Lbc Rho GEF, suggesting modulation by 5-HT...
  9. Gerovska D, Araúzo Bravo M. Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?. Mol Hum Reprod. 2016;22:208-25 pubmed publisher
    ..5 and steady PE and EPI markers. Among the transitory E3.5 PE markers (Dnmt3l, Dusp4, Cpne8, Akap13, Dcaf12l1, Aaed1, B4galt6, BC100530, Rnpc3, Tfpi, Lgalsl, Ckap4 and Fbxl20), several (Dusp4, Akap13, Cpn8, ..
  10. Menezes A, Ramos C, Dias D, Schwan R. Combination of probiotic yeast and lactic acid bacteria as starter culture to produce maize-based beverages. Food Res Int. 2018;111:187-197 pubmed publisher
    ..In the present work, the commercial probiotic, Lactobacillus paracasei LBC-81, was used singly and in co-culture with potential probiotic yeasts, Saccharomyces cerevisiae CCMA 0731, S...
  11. Shepard R, Gouty S, Kassis H, Berenji A, Zhu W, Cox B, et al. Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA. Exp Neurol. 2018;309:160-168 pubmed publisher
    ..Our data suggest that HDAC-mediated targeting of BDNF and AKAP-dependent local signaling within VTA could provide novel therapeutics for prevention of later-life psychopathology. ..
  12. Kumar N, Gupta S, Dabral S, Singh S, Sehrawat S. Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis. Mol Cell Biochem. 2017;430:115-125 pubmed publisher
    ..This study provides a new cell signaling cAMP-EPAC1-AKAP9 direction to the development of additional biotherapeutics for breast cancer. ..
  13. Vizel R, Hillman P, Ickowicz D, Breitbart H. AKAP3 degradation in sperm capacitation is regulated by its tyrosine phosphorylation. Biochim Biophys Acta. 2015;1850:1912-20 pubmed publisher
    ..Better understanding of the molecular mechanisms that mediate sperm capacitation can be used for infertility diagnosis, treatment and the developing of male contraceptives. ..
  14. Kerns K, Morales P, Sutovsky P. Regulation of Sperm Capacitation by the 26S Proteasome: An Emerging New Paradigm in Spermatology. Biol Reprod. 2016;94:117 pubmed publisher
    ..Altogether, the studies reviewed here support the involvement of UPS in sperm capacitation and present opportunities for new discoveries. ..
  15. Flippo K, Gnanasekaran A, Perkins G, Ajmal A, Merrill R, Dickey A, et al. AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. J Neurosci. 2018;38:8233-8242 pubmed publisher
    ..In summary, our work settles current controversies regarding the role of mitochondrial fission in neuronal injury, provides mechanisms, and suggests that fission inhibitors hold promise as future therapeutic agents. ..
  16. Yu L, Chen W, Lei X, Qin Y, Wu Z, Pan Q, et al. Evaluation of p16/Ki-67 dual staining in detection of cervical precancer and cancers: a multicenter study in China. Oncotarget. 2016;7:21181-9 pubmed publisher
    ..Cervical specimens were collected for high-risk human papillomavirus (HR-HPV) DNA analysis, Liquid-based cytology (LBC) and p16/Ki-67 dual staining. Colposcopy and biopsy were performed on women with any abnormal result...
  17. Li L, Li J, Drum B, Chen Y, Yin H, Guo X, et al. Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve. Cardiovasc Res. 2017;113:147-159 pubmed publisher
  18. Li Z, Singh S, Suryavanshi S, Ding W, Shen X, Wijaya C, et al. Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice. Eur J Pharmacol. 2017;807:117-126 pubmed publisher
    ..Further elucidation of the mechanism can provide insights to role of gravin if any in the pathophysiology of impaired contractility. ..
  19. Chandrangsu P, Loi V, Antelmann H, Helmann J. The Role of Bacillithiol in Gram-Positive Firmicutes. Antioxid Redox Signal. 2018;28:445-462 pubmed publisher
    ..Although the functions of the bacilliredoxin (Brx) pathways in the reversal of S-bacillithiolations have been recently addressed, significantly more work is needed ..
  20. Li J, Aponte Paris S, Thakur H, Kapiloff M, Dodge Kafka K. Muscle A-kinase-anchoring protein-β-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D. J Biol Chem. 2019;294:2543-2554 pubmed publisher
    ..Together, these results highlight the importance of mAKAPβ signalosomes for regulating MEF2D activity in striated muscle, affirming mAKAPβ as a nodal regulator in the myocyte intracellular signaling network. ..
  21. Bandje K, Naissant B, Bigey P, Lohezic M, Vayssières M, Blaud M, et al. Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum. Malar J. 2016;15:248 pubmed publisher
    ..The interaction of PfAKAL with PfPKA-R could be indirectly mediated through a join interaction with Pf14-3-3I. Therefore, PfPKA localization could not depend on PfAKAL, but rather involves other partners. ..
  22. Zhang J, Feng J, Ma D, Wang F, Wang Y, Li C, et al. Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress. Mol Neurobiol. 2019;: pubmed publisher
  23. Guo S, Yan W, McDonough S, Lin N, Wu K, He H, et al. The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model. Vaccine. 2015;33:1586-95 pubmed publisher
    ..The immunogenicity of the genetically engineered L. lactis oral vaccine delivery system (animal groups LAC and LBC or the combination of both, LACBC) was compared with the recombinant TcdA and TcdB C-terminal receptor binding ..
  24. Marstad A, Landsverk O, Strømme O, Otterlei M, Collas P, Sundan A, et al. A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis. FEBS J. 2016;283:757-70 pubmed publisher
    ..Taken together, our data indicate that AKAP95 is a novel nucleolus-associated protein with a regulatory role on rRNA production. ..
  25. Stevenson A, Kavanagh K, Pan J, Stevenson L, Griffin H, Doorbar J, et al. Risk stratification of cervical disease using detection of human papillomavirus (HPV) E4 protein and cellular MCM protein in clinical liquid based cytology samples. J Clin Virol. 2018;108:19-25 pubmed publisher
    ..IHC)-based dual viral and cellular biomarker strategy which was applicable to liquid based cytology (LBC) samples...
  26. Nikandrova Y, Jiao Y, Baucum A, Tavalin S, Colbran R. Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activ. J Biol Chem. 2010;285:923-34 pubmed publisher
  27. Schimenti K, Feuer S, Griffin L, Graham N, Bovet C, Hartford S, et al. AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice. Genetics. 2013;194:447-57 pubmed publisher
    ..These results identify and support a novel reproductive tissue-specific role for Akap9 in the coordinated regulation of Sertoli cells in the testis. ..
  28. Lee S, Won J, Yang J, Lee J, Kim S, Lee E, et al. AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin. Sci Rep. 2015;5:16523 pubmed publisher
    ..Taken together, our findings demonstrate a novel interplay between AKAP6 and myogenin, and we suggest that AKAP6 is an important regulator of myoblast differentiation, myotube formation, and muscle regeneration. ..
  29. Wirtenberger M, Schmutzhard J, Hemminki K, Meindl A, Sutter C, Schmutzler R, et al. The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer. Carcinogenesis. 2007;28:423-6 pubmed
    ..25, 95% confidence interval (CI) 1.03-1.51, P=0.024]. Our previous study has shown that AKAP13 Lys526Gln is associated with familial breast cancer (OR=1.58)...
  30. Yang T, Li C, Zhou C, Jiang S, Chu J, Medina A, et al. Parental migration and smoking behavior of left-behind children: evidence from a survey in rural Anhui, China. Int J Equity Health. 2016;15:127 pubmed publisher
    ..the smoking behavior of children and identify factors associated with smoking behavior among left-behind children (LBC). A cross-sectional study was conducted in 6 cities in Anhui province during July and August, 2012...
  31. Latsuzbaia A, Hebette G, Fischer M, Arbyn M, Weyers S, Vielh P, et al. Introduction of liquid-based cytology and human papillomavirus testing in cervical cancer screening in Luxembourg. Diagn Cytopathol. 2017;45:384-390 pubmed publisher
    ..The aim of our study was to compare conventional and liquid-based cytology (LBC), estimate the prevalence of abnormal cervical cytology and high risk HPV (hrHPV) infection and their correlation, ..
  32. Bahrami A, Jafarmadar M, Redl H, Bahrami S, Jiang J. TNF-? release capacity is suppressed immediately after hemorrhage and resuscitation. Chin J Traumatol. 2017;20:207-211 pubmed publisher
    ..WB was incubated with LPS (100 ng/mL) for 2 h at 37 °C. TNF-? concentration and LPS binding capacity (LBC) was determined...
  33. Shibolet O, Giallourakis C, Rosenberg I, Mueller T, Xavier R, Podolsky D. AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling. J Biol Chem. 2007;282:35308-17 pubmed
    ..expression profiles from immune and epithelial cells with functional studies, we demonstrate that protein kinase A anchoring protein 13 (AKAP13), a scaffold protein with GEF activity, is an activator of NF-kappaB downstream of TLR2 ..
  34. Wei Q, Fu B, Liu J, Xu J, Zhao T. Combined detection of p16(INK4a) and IMP3 increase the concordance rate between cervical cytologic and histologic diagnosis. Int J Clin Exp Pathol. 2013;6:1549-57 pubmed
    Currently, there are discrepancies in the interpretation between cervical liquid-based cytology (LBC) and histologic diagnoses...
  35. Bizzarro T, Martini M, Marrocco C, D Amato D, Traini E, Lombardi C, et al. The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology. PLoS ONE. 2015;10:e0132939 pubmed publisher
    ..Inasmuch as this is the largest pilot study using only liquid based cytology (LBC), we selected all the cases only in the categories of benign nodules (BN) and positive for malignancy (PM) for ..
  36. Cubie H, Morton D, Kawonga E, Mautanga M, Mwenitete I, Teakle N, et al. HPV prevalence in women attending cervical screening in rural Malawi using the cartridge-based Xpert® HPV assay. J Clin Virol. 2017;87:1-4 pubmed publisher
    ..Liquid-based cytology (LBC) specimens were collected from women attending cervical screening clinics in Nkhoma, Malawi...
  37. Machuki J, Zhang H, Harding S, Sun H. Molecular pathways of oestrogen receptors and ?-adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic value. Acta Physiol (Oxf). 2017;: pubmed publisher
    ..Finally, we highlight promising therapeutic avenues that can be derived from the shared pathways, especially the phosphatidylinositol-3-OH kinase (PI3K/Akt) pathway...
  38. Rossi E, Bizzarro T, Martini M, Capodimonti S, Sarti D, Cenci T, et al. The evaluation of miRNAs on thyroid FNAC: the promising role of miR-375 in follicular neoplasms. Endocrine. 2016;54:723-732 pubmed publisher
    ..We aimed to define whether liquid-based cytology (LBC) is a valid method for miRNA evaluation...
  39. Pryde K, Smith H, Chau K, Schapira A. PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy. J Cell Biol. 2016;213:163-71 pubmed publisher
    ..We confirm that PINK1 mutations causing Parkinson disease interfere with the orchestration of selective fission and mitophagy by PINK1. ..
  40. Capkin E, Ozcelep T, Kayis S, Altinok I. Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout. Chemosphere. 2017;182:720-729 pubmed publisher
    ..PCMX) and methylisothiazolinone (MIT) have been commonly used as an antimicrobial in soaps while borax (BRX) is used in household cleaning...
  41. Kaye E, Kurbidaeva A, Wolle D, Aoki T, Schedl P, Larschan E. Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex. Mol Cell Biol. 2017;37: pubmed publisher
    ..Here, we show that an ∼1,000-kDa complex called the late boundary complex (LBC), which is required for the functioning of the Bithorax complex boundary Fab-7, interacts specifically with ..
  42. Xu W, Yan N, Chen G, Zhang X, Feng T. Parent-child separation: the relationship between separation and psychological adjustment among Chinese rural children. Qual Life Res. 2018;27:913-921 pubmed publisher
    ..current study aimed to explore the characteristics of psychological adjustment among Chinese left-behind children (LBC) in rural areas, and to examine the association between separation duration from parent/parents (SDP) and children'..
  43. Carr D, Hausken Z, Fraser I, Stofko Hahn R, Scott J. Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J Biol Chem. 1992;267:13376-82 pubmed
    ..The nanomolar affinity constant and the different patterns of RII-anchoring proteins in each tissue suggest that the type II alpha PKA holoenzyme may be specifically targeted to different locations in each type of cell. ..
  44. Merrill R, Slupe A, Strack S. N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival. FEBS J. 2013;280:662-73 pubmed publisher
    ..These results reveal another layer of complexity in the regulation of the mitochondrial fission-fusion equilibrium and its physiological and pathophysiological consequences in the nervous system. ..
  45. Poulsen J, Kjær K, Justesen J, Martensen P. Enzyme assays for synthesis and degradation of 2-5As and other 2'-5' oligonucleotides. BMC Biochem. 2015;16:15 pubmed publisher
    ..Assays are presented for both enzyme families. The assays can also be used to address a broader cellular role of the OAS enzymes, based on the multiple substrate specificity intrinsic to these proteins. ..
  46. Burgers P, Bruystens J, Burnley R, Nikolaev V, Keshwani M, Wu J, et al. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. FEBS J. 2016;283:2132-48 pubmed publisher
    ..This represents a novel mechanism, whereby activation of anchored PKA can terminate its binding to smAKAP affecting the regulation of localized cAMP signaling events. Structural data are available in the PDB under accession number 5HVZ. ..
  47. Dodge Kafka K, Gildart M, Li J, Thakur H, Kapiloff M. Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes. J Mol Cell Cardiol. 2018;118:13-25 pubmed publisher
    ..Thus, the mAKAPβ scaffold serves as a node in the myocyte regulatory network controlling both the repression and activation of pathological gene expression in health and disease, respectively. ..
  48. Lewis T, Milam T, Klingler D, Rao P, Jaggi M, Smith D, et al. Tissue transglutaminase interacts with protein kinase A anchor protein 13 in prostate cancer. Urol Oncol. 2005;23:407-12 pubmed
    ..a strong and novel interaction between the transglutaminase moiety and protein kinase A anchor protein 13 (AKAP13), which was quantified by beta-galactosidase assay, confirmed in vitro by immunoprecipitation experiments using ..
  49. Li C, Le K, Kato J, Moss J, Vaughan M. Enhancement of ?-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals. Proc Natl Acad Sci U S A. 2016;113:5946-51 pubmed publisher
  50. Fujii T, Asano A, Shimada K, Tatsumi Y, Obayashi C, Konishi N. Evaluation of RNA and DNA extraction from liquid-based cytology specimens. Diagn Cytopathol. 2016;44:833-40 pubmed publisher
    ..we compared the qualitative extraction of RNA and DNA from cancer cells fixed using several liquid-based cytology (LBC) kits...
  51. Man Y, Mengmeng L, Lezhi L, Ting M, Jingping Z. The psychological problems and related influential factors of left-behind adolescents (LBA) in Hunan, China: a cross sectional study. Int J Equity Health. 2017;16:163 pubmed publisher
    Due to lack of companionship of parents, compared with non left behind children, left behind children (LBC) suffer from more psychological problems compared with children live with their parents...
  52. Stanczuk G, Baxter G, Currie H, Forson W, Lawrence J, Cuschieri K, et al. Defining Optimal Triage Strategies for hrHPV Screen-Positive Women-An Evaluation of HPV 16/18 Genotyping, Cytology, and p16/Ki-67 Cytoimmunochemistry. Cancer Epidemiol Biomarkers Prev. 2017;26:1629-1635 pubmed publisher
    ..cases and controls, all of whom tested hrHPV+ and whose results of liquid-based cytology (LBC), HPV16/18 genotyping, and p16/Ki67 cytoimmunochemistry were available...
  53. Caso S, Maric D, Arambasic M, Cotecchia S, Diviani D. AKAP-Lbc mediates protection against doxorubicin-induced cardiomyocyte toxicity. Biochim Biophys Acta Mol Cell Res. 2017;1864:2336-2346 pubmed publisher
    ..Importantly, our results indicate that AKAP-Lbc is critical for transducing protective signals downstream of ?1-ARs...
  54. Kragh K, Alhede M, Rybtke M, Stavnsberg C, Jensen P, Tolker Nielsen T, et al. The Inoculation Method Could Impact the Outcome of Microbiological Experiments. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..Once formed, these aggregates are hard to remove. Aggregates in liquid cultures may be an immense unseen challenge for microbiologists. ..
  55. Eldredge Hindy H, Lockamy V, Crawford A, Nettleton V, Werner Wasik M, Siglin J, et al. Active Breathing Coordinator reduces radiation dose to the heart and preserves local control in patients with left breast cancer: report of a prospective trial. Pract Radiat Oncol. 2015;5:4-10 pubmed publisher
    ..Patients with stages 0-III left breast cancer (LBC) were enrolled and underwent simulation with both free breathing (FB) and ABC for comparison of dosimetry...
  56. Chen X, Kong X, Zhuang W, Teng B, Yu X, Hua S, et al. Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells. Sci Rep. 2016;6:21224 pubmed publisher
    ..dynamic interaction between AKAP95 and Cx43 varies with cell cycle progression to regulate multiple biological processes. ..
  57. Jun Y, Park H, Lee Y, Kaang B, Lee J, Jang D. D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane. FEBS Lett. 2016;590:954-61 pubmed publisher
    ..Taken together, D-AKAP1a can be classified as a signal-anchored protein in the MOM. Our topological study provides valuable information about the molecular and cellular mechanisms of mitochondrial targeting of AKAP1. ..
  58. Rossi E, Bizzarro T, Martini M, Capodimonti S, Cenci T, Fadda G, et al. Morphological features that can predict BRAFV600E -mutated carcinoma in paediatric thyroid cytology. Cytopathology. 2017;28:55-64 pubmed publisher
    ..Cytological cases were processed with liquid-based cytology (LBC). BRAFV600E and immunocytochemistry for the VE1 antibody were performed on LBC...
  59. Diviani D, Osman H, Reggi E. A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection. J Cardiovasc Dev Dis. 2018;5: pubmed publisher
    ..AKAP-Lbc, a cardiac enriched anchoring protein, has been shown to act as a key coordinator of the activity of signaling ..
  60. Stott J, Barrese V, Greenwood I. Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries. Arterioscler Thromb Vasc Biol. 2016;36:2404-2411 pubmed
    ..EPAC-dependent vasorelaxations occur in part via activation of Kv7 channels. This contributes to the isoproterenol-mediated relaxation in mesenteric, but not renal, arteries. ..
  61. Arul P, Shetty S, Masilamani S, Akshatha C, Naveen Kumar B. Evaluation of Micronucleus in Exfoliated Buccal Epithelial Cells Using Liquid-based Cytology Preparation in Petrol Station Workers. Indian J Med Paediatr Oncol. 2017;38:273-276 pubmed publisher
    Liquid-based cytology (LBC) can be used for the evaluation of micronucleus (MN) in exfoliated buccal epithelial cells of populations occupationally exposed to potentially carcinogenic agents.
  62. Potet F, Scott J, Mohammad Panah R, Escande D, Baro I. AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex. Am J Physiol Heart Circ Physiol. 2001;280:H2038-45 pubmed
    ..The effects of cAMP stimulation were fully prevented by including the Ht31 peptide (a global disruptor of protein kinase A anchoring) in the intracellular medium...
  63. Chiocchetti A, Yousaf A, Bour H, Haslinger D, Waltes R, Duketis E, et al. Common functional variants of the glutamatergic system in Autism spectrum disorder with high and low intellectual abilities. J Neural Transm (Vienna). 2018;125:259-271 pubmed publisher
    ..However, we report a replicated nominal significant under-transmission (OR < 0.79, p < 0.04) of the AKAP13 rs745191-T allele in both LIQ cohorts, but not in the much larger HIQ cohorts...
  64. Alto N, Soderling S, Hoshi N, Langeberg L, Fayos R, Jennings P, et al. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003;100:4445-50 pubmed
    ..Thus, computer-based and peptide array screening approaches have generated a reagent that binds PKA with higher affinity than previously described AKAPs. ..
  65. Molee P, Adisakwattana P, Reamtong O, Petmitr S, Sricharunrat T, Suwandittakul N, et al. Up-regulation of AKAP13 and MAGT1 on cytoplasmic membrane in progressive hepatocellular carcinoma: a novel target for prognosis. Int J Clin Exp Pathol. 2015;8:9796-811 pubmed
    ..The results showed that two proteins, magnesium transporter protein 1 (MAGT1) and A-kinase anchor protein 13 (AKAP13), were highly expressed in PMA-treated HepG2 cells...
  66. Nygren P, Mehta S, Schweppe D, Langeberg L, Whiting J, Weisbrod C, et al. Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. elife. 2017;6: pubmed publisher
    ..Live-cell imaging with fluorescent activity-sensors infers that this region fine-tunes calcium responsiveness and drug sensitivity of the anchored phosphatase. ..
  67. Lynch A, Crowley E, Casey E, Cano R, Shanahan R, McGlacken G, et al. The Bacteroidales produce an N-acylated derivative of glycine with both cholesterol-solubilising and hemolytic activity. Sci Rep. 2017;7:13270 pubmed publisher
    ..01% (w/v) cholesterol (LBC agar)...
  68. Larsen M, Kornblit B, Larsen M, Masmas T, Nielsen M, Thiim M, et al. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2010;16:1370-81 pubmed publisher
    ..Furthermore, our data suggest a possible role for in silico based miHA predictions in donor selection as well as in selecting candidate miHAs for further evaluation in in vitro and in vivo experiments. ..
  69. Vitart V, Bencić G, Hayward C, Skunca Herman J, Huffman J, Campbell S, et al. New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8. Hum Mol Genet. 2010;19:4304-11 pubmed publisher
    ..3 (? = 0.13, P = 1.4 × 10(-8)), was within a wide linkage disequilibrium block extending into the 5' end of the AKAP13 gene, encoding a scaffold protein concerned with signal transduction from the cell surface...
  70. Ma L, Dong F, Denis M, Feng Y, Wang M, Zha X. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011;286:3370-8 pubmed publisher
    ..Here we report that a protein kinase A (PKA)-anchoring inhibitor, st-Ht31, induces robust cholesterol/phospholipid efflux, and ATP-binding cassette transporter A1 (ABCA1) greatly ..
  71. Fehér L, Pocsay G, Krenacs L, Zvara A, Bagdi E, Pocsay R, et al. Amplification of thymosin beta 10 and AKAP13 genes in metastatic and aggressive papillary thyroid carcinomas. Pathol Oncol Res. 2012;18:449-58 pubmed publisher
    ..difference could be detected between the good and bad prognosis cases in the A-kinase anchor protein 13 (AKAP13) gene region, it was discriminative markers for metastasis...
  72. Wang Q, Cobo Stark P, Patel V, Somlo S, Han P, Igarashi P. Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease. Kidney Int. 2018;93:403-415 pubmed publisher
    ..Thus, AC5 contributes importantly to increased renal cAMP levels and cyst growth in Pkd2 mutant mice, and inhibition of AC5 may be beneficial in the treatment of PKD. ..
  73. Heinold A, Opelz G, Scherer S, Ruhenstroth A, Laux G, Doehler B, et al. Role of minor histocompatibility antigens in renal transplantation. Am J Transplant. 2008;8:95-102 pubmed
    ..None of the mHag disparities showed a statistically significant effect on death-censored 5-year graft survival. This report represents the first large-scale study on the relevance of mHags in kidney transplantation. ..
  74. Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, et al. The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALKATI) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner. Biol Pharm Bull. 2017;40:1968-1975 pubmed publisher
    ..These results suggest that ALKATI induces chromatin structural changes and heterochromatinization through phosphorylation of AKAP8 in the nucleus. ..
  75. Carr D, Stofko Hahn R, Fraser I, Bishop S, Acott T, Brennan R, et al. Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. J Biol Chem. 1991;266:14188-92 pubmed
    ..These data suggest that anchoring proteins interact with RII alpha via an amphipathic helix binding motif. ..
  76. Hearns Stokes R, Mayers C, Zahn C, Cruess D, Gustafsson J, Segars J, et al. Expression of the proto-oncoprotein breast cancer nuclear receptor auxiliary factor (Brx) is altered in eutopic endometrium of women with endometriosis. Fertil Steril. 2006;85:63-70 pubmed
    ..receptor alpha (ERalpha), estrogen receptor beta (ERbeta), and breast cancer nuclear receptor auxiliary factor (Brx) in eutopic endometrium of normal women and women with endometriosis. Prospective observational study...
  77. Dema A, Schröter M, Perets E, Skroblin P, Moutty M, Deák V, et al. The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3? Interaction Protein (GSKIP) Regulates ?-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3?. J Biol Chem. 2016;291:19618-30 pubmed publisher
  78. Kondo S, Kawashima J, Kobata K, Ohgawara T, Tanaka S, Nabeshima K, et al. Oral pemphigus vulgaris: Liquid-based cytological findings and pitfalls. Diagn Cytopathol. 2018;46:63-66 pubmed publisher
    ..As atypical squamous cells were present even in the liquid-based cytological (LBC) smears of the oral lesion in these two cases, this ultimately led to the misinterpretation of squamous cell ..
  79. Kolobova E, Roland J, Lapierre L, Williams J, Mason T, Goldenring J. The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins. J Biol Chem. 2017;292:20394-20409 pubmed publisher
    ..These results suggest that AKAP350A acts as a scaffold for factors involved in microtubule nucleation at the centrosome and coordinates the assembly of protein complexes associating with the intercentriolar bridge. ..
  80. Srikram R, Jarumaneeroj P, Chaiwatanarat T, Rakvongthai Y. Preoperative parathyroid localization using joint planar imaging. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:624-627 pubmed publisher
    ..planar datasets were combined and scaled to simulate noise-free clinical MIBI (four lesion-to-background contrast (LBC) values: 1.2, 1.3, 1.4 and 1.5), and 99mTcO4- datasets...
  81. Dutt P, Nguyen N, Toksoz D. Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase. Cell Signal. 2004;16:201-9 pubmed
    ..Here, we have evaluated the signaling capacity of Lbc RhoGEF in the context of Galpha12/13 signals...
  82. Khan A, Munir M, Aiman S, Wadood A, Khan A. The in silico identification of small molecules for protein-protein interaction inhibition in AKAP-Lbc-RhoA signaling complex. Comput Biol Chem. 2017;67:84-91 pubmed publisher
    ..The A-Kinase Anchoring Protein, i.e. AKAP-Lbc, catalyses nucleotide exchange on RhoA and is involved in cardiac repolarization...
  83. Guang Y, Feng Z, Yang G, Yang Y, Wang L, Dai Q, et al. Depressive symptoms and negative life events: What psycho-social factors protect or harm left-behind children in China?. BMC Psychiatry. 2017;17:402 pubmed publisher
    ..6 months by either one or both of their parents migrating to work in cities are called "left-behind children (LBC)"...
  84. Xie G, Raufman J. Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1051-8 pubmed
    ..Confocal microscopy revealed colocalized staining at the cell periphery for AKAP150 and PKC. Ht31, a peptide that competitively displaces PKA from the AKAP complex, but not Ht31P, a control peptide, inhibited 8-Br-..
  85. Abdul Azeez K, Knapp S, Fernandes J, Klussmann E, Elkins J. The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex. Biochem J. 2014;464:231-9 pubmed publisher
    ..Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy...
  86. Cléard F, Wolle D, Taverner A, Aoki T, Deshpande G, Andolfatto P, et al. Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex. Genetics. 2017;205:589-603 pubmed publisher
    ..Consistent with this functional conservation, the two known Fab-7 boundary factors, Elba and LBC, have recognition sequences in the boundaries from all species...
  87. Chu D, Tao Y, Tasken K. OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes. Horm Metab Res. 2017;49:276-285 pubmed publisher
    ..However, the function of OPA1 in lipolysis and thermogenesis in inducible brown adipocytes (brite/beige cells) remains elusive. Here we discuss the role of OPA1 in lipid metabolism. ..
  88. Chen L, Zuraw B, Ye R, Pan Z. A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes. J Biol Chem. 2004;279:7208-12 pubmed
    ..Chem. 276, 40977-40981). Here we present evidence that RhoA associates specifically with the guanine nucleotide exchange factor Lbc in human peripheral blood monocytes stimulated with fMLP and that Lbc specifically catalyzes the ..
  89. Rolland D, Ribrag V, Haioun C, Ghesquieres H, Jardin F, Bouabdallah R, et al. Phase II trial and prediction of response of single agent tipifarnib in patients with relapsed/refractory mantle cell lymphoma: a Groupe d'Etude des Lymphomes de l'Adulte trial. Cancer Chemother Pharmacol. 2010;65:781-90 pubmed publisher
    ..was retrospectively evaluated in the initial tumor biopsy by the RASGRP1/APTX gene expression ratio, and the AKAP13 expression level. Eleven patients (median age, 71 years) were enrolled...
  90. Fingerlin T, Murphy E, Zhang W, Peljto A, Brown K, Steele M, et al. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet. 2013;45:613-20 pubmed publisher
    ..Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs. ..
  91. Bentin Toaldo C, Alexi X, Beelen K, Kok M, Hauptmann M, Jansen M, et al. Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13. BMC Cancer. 2015;15:588 pubmed publisher
    ..tumors on ERα Serine 305 phosphorylation status resulted in the identification of a gene network centered upon AKAP13. AKAP13 mRNA expression levels correlate with poor outcome in patients who received tamoxifen treatment in the ..
  92. Dukic A, Haugen L, Pidoux G, Leithe E, Bakke O, Tasken K. A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells. Cell Signal. 2017;32:1-11 pubmed publisher
    ..Moreover, loading of cells with the Ht31 peptide that displaces both PKA RI? and RII? from the AKAP or a peptide that disrupts the Cx43-Ezrin interaction ..