Gene Symbol: AKAP11
Description: A-kinase anchoring protein 11
Alias: AKAP-11, AKAP220, PPP1R44, PRKA11, A-kinase anchor protein 11, A kinase (PRKA) anchor protein 11, A-kinase anchor protein 220 kDa, A-kinase anchoring protein, 220kDa, a kinase anchor protein 220 kDa, protein kinase A anchoring protein 11, protein phosphatase 1, regulatory subunit 44
Species: human
Products:     AKAP11

Top Publications

  1. Lester L, Coghlan V, Nauert B, Scott J. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. J Biol Chem. 1996;271:9460-5 pubmed
    ..Collectively, these results suggest that AKAP 220 may play a role in targeting type II PKA for cAMP-responsive peroxisomal events. ..
  2. Schillace R, Scott J. Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Curr Biol. 1999;9:321-4 pubmed
    ..Here, we demonstrate that the PKA-anchoring protein, AKAP220, binds PP1c with a dissociation constant (KD) of 12.1 +/- 4 nM in vitro...
  3. Reinton N, Collas P, Haugen T, Skalhegg B, Hansson V, Jahnsen T, et al. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. Dev Biol. 2000;223:194-204 pubmed
    ..a 1901-amino-acid A-kinase-anchoring protein (AKAP) with an apparent SDS-PAGE mobility of 220 kDa, named human AKAP220 (hAKAP220)...
  4. Schillace R, Voltz J, Sim A, Shenolikar S, Scott J. Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. J Biol Chem. 2001;276:12128-34 pubmed
    ..We previously reported that a 220-kDa A-kinase anchoring protein (AKAP220) coordinates the location of the cAMP-dependent protein kinase (PKA) and the type 1 protein phosphatase catalytic ..
  5. Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A. A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J Biol Chem. 2002;277:36955-61 pubmed
    ..Using yeast two-hybrid screening, we found that GSK-3beta binds to AKAP220, which is known to act as an A-kinase anchoring protein...
  6. Correa Rodríguez M, Schmidt Río Valle J, Rueda Medina B. AKAP11 gene polymorphism is associated with bone mass measured by quantitative ultrasound in young adults. Int J Med Sci. 2018;15:999-1004 pubmed publisher
    ..bone status in clinical practice, and ZBTB40 (rs7524102, rs6426749), SP7 (rs2016266) and AKAP11 (rs9533090) genes...
  7. Whiting J, Ogier L, Forbush K, Bucko P, Gopalan J, Seternes O, et al. AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A. 2016;113:E4328-37 pubmed publisher
    ..facets of this homeostatic mechanism are under the control of A-Kinase Anchoring Protein 220 (AKAP220; product of the Akap11 gene)...
  8. Lill C, Liu T, Norman K, Meyer A, Steinhagen Thiessen E, Demuth I, et al. Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II). Gerontology. 2016;62:316-22 pubmed publisher
    ..40 × 10-4, pLS = 1.09 × 10-4; TNFRSF11B rs2062377, pLS = 8.70 × 10-4; AKAP11 rs9533090, pLS = 1.05 × 10-3; SMG6 rs4790881, pFN = 3.41 × 10-4) after correction for multiple testing...
  9. Mikitová V, Levine T. Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2. PLoS ONE. 2012;7:e30455 pubmed publisher
    ..the functions of which had not previously been directly linked to the ER, including: two PKA anchoring proteins, AKAP220 and AKAP110; a family of plant LTPs; and the glycolipid LTP phosphatidylinositol-four-phosphate adaptor-protein-2 ..

More Information


  1. Logue J, Whiting J, Tunquist B, Sacks D, Langeberg L, Wordeman L, et al. AKAP220 protein organizes signaling elements that impact cell migration. J Biol Chem. 2011;286:39269-81 pubmed publisher
    ..We have discovered that the protein kinase A anchoring protein AKAP220 interacts with the cytoskeletal scaffolding protein IQGAP1 to influence cell motility...
  2. Nielson C, Liu C, Smith A, Ackert Bicknell C, Reppe S, Jakobsdottir J, et al. Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. J Bone Miner Res. 2016;31:2085-2097 pubmed publisher
    ..12, containing WNT4 and ZBTB40; 8q24, containing TNFRSF11B; and 13q14, containing AKAP11 and TNFSF11. Two loci (5p13 and 1p36...
  3. Whiting J, Nygren P, Tunquist B, Langeberg L, Seternes O, Scott J. Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220. J Biol Chem. 2015;290:19445-57 pubmed publisher
    ..A-kinase anchoring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a variety of signal transduction enzymes...
  4. Alto N, Soderling S, Hoshi N, Langeberg L, Fayos R, Jennings P, et al. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003;100:4445-50 pubmed
    ..Thus, computer-based and peptide array screening approaches have generated a reagent that binds PKA with higher affinity than previously described AKAPs. ..
  5. Zhang L, Choi H, Estrada K, Leo P, Li J, Pei Y, et al. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet. 2014;23:1923-33 pubmed publisher
    ..3 (FLJ42280, SHFM1), 7q31.31 (FAM3C, WNT16), 8q24.12 (TNFRSF11B), 11p15.3 (SOX6), 11q13.4 (LRP5), 13q14.11 (AKAP11) and 16q24 (FOXL1)...
  6. Radeva M, Kugelmann D, Spindler V, Waschke J. PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. PLoS ONE. 2014;9:e106733 pubmed publisher
    ..Similarly, membrane localization of AKAP220 was also reduced...
  7. Schillace R, Andrews S, Liberty G, Davey M, Carr D. Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. J Immunol. 2002;168:1590-9 pubmed
    ..Screening of a PMA-stimulated Jurkat cell library identified two additional known AKAPs, AKAP220 and AKAP-KL, and one novel AKAP, myeloid translocation gene 16 (MTG16b)...
  8. Dema A, Schröter M, Perets E, Skroblin P, Moutty M, Deák V, et al. The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3? Interaction Protein (GSKIP) Regulates ?-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3?. J Biol Chem. 2016;291:19618-30 pubmed publisher
    ..The regulation of ?-catenin by GSKIP is specific for this AKAP as AKAP220, which also binds PKA and GSK3?, did not affect Wnt signaling...
  9. Michel J, Scott J. AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol. 2002;42:235-57 pubmed
    ..This review details the most recent advances in our understanding of the various biological functions dependent upon AKAP-anchored signaling complexes. ..
  10. Lester L, Scott J. Anchoring and scaffold proteins for kinases and phosphatases. Recent Prog Horm Res. 1997;52:409-29; discussion 429-30 pubmed
    ..Collectively, these studies suggest that the AKAPs represent a growing family of regulatory proteins that provide a molecular architecture that organizes the intracellular location of a single or multiple multifunctional kinase. ..