AKAP1

Summary

Gene Symbol: AKAP1
Description: A-kinase anchoring protein 1
Alias: AKAP, AKAP121, AKAP149, AKAP84, D-AKAP1, PPP1R43, PRKA1, SAKAP84, TDRD17, A-kinase anchor protein 1, mitochondrial, A kinase (PRKA) anchor protein 1, A-kinase anchor protein 149 kDa, AKAP 149, D-AKAP-1, dual-specificity A-kinase anchoring protein 1, protein kinase A anchoring protein 1, protein kinase A1, protein phosphatase 1, regulatory subunit 43, spermatid A-kinase anchor protein 84, testicular secretory protein Li 5, tudor domain containing 17
Species: human
Products:     AKAP1

Top Publications

  1. Willoughby D, Wong W, Schaack J, Scott J, Cooper D. An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J. 2006;25:2051-61 pubmed
    ..selective inhibitors of type 4 phosphodiesterases (PDE4), protein kinase A (PKA) or PKA/A-kinase anchoring protein (AKAP) interaction blocked an immediate return of subplasmalemmal cAMP to basal levels...
  2. Huang L, Durick K, Weiner J, Chun J, Taylor S. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem. 1997;272:8057-64 pubmed
    ..This core sequence was homologous to S-AKAP84, including a mitochondrial signal sequence near the amino terminus (Lin, R. Y., Moss, S. B., and Rubin, C. S...
  3. Herberg F, Maleszka A, Eide T, Vossebein L, Tasken K. Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. J Mol Biol. 2000;298:329-39 pubmed
    ..We show that both AKAP79 and S-AKAP84/D-AKAP1 bind RIIalpha very well (apparent K(D) values of 0.5 and 2 nM, respectively)...
  4. Steen R, Beullens M, Landsverk H, Bollen M, Collas P. AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase. J Cell Sci. 2003;116:2237-46 pubmed
    ..requires targeting of the B-type lamin protein phosphatase, PP1, to the envelope by A-kinase anchoring protein AKAP149. We show here that NE-associated AKAP149 is a novel PP1-specifying subunit involved in maintaining nuclear ..
  5. Trendelenburg G, Hummel M, Riecken E, Hanski C. Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain. Biochem Biophys Res Commun. 1996;225:313-9 pubmed
    ..A new member of the AKAP family, a membrane-anchored 903 amino acid long protein, designated AKAP149, is characterized in the present work...
  6. Steen R, Martins S, Tasken K, Collas P. Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. J Cell Biol. 2000;150:1251-62 pubmed
    ..We report that in addition to anchoring PKA, A-kinase anchoring protein AKAP149 recruits PP1 at the nuclear envelope (NE) upon somatic nuclear reformation in vitro, and that PP1 targeting to ..
  7. Razani B, Lisanti M. Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. Am J Physiol Cell Physiol. 2001;281:C1241-50 pubmed
    ..e., the mutant acts in a dominant-negative fashion. Thus, this dominant-negative caveolin-1 mutant will be extremely valuable for assessing the functional role of endogenous caveolin-1 in regulating a variety of other signaling cascades...
  8. Warrilow D, Tachedjian G, Harrich D. Maturation of the HIV reverse transcription complex: putting the jigsaw together. Rev Med Virol. 2009;19:324-37 pubmed publisher
    ..Determining precisely how these proteins assist the RTC function needs to be addressed. ..
  9. Lin R, Moss S, Rubin C. Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. J Biol Chem. 1995;270:27804-11 pubmed
    ..We now report the cloning of a cDNA that encodes a novel, germ cell A kinase anchor protein (AKAP) designated S-AKAP84. S-AKAP84 comprises 593 amino acids and contains a centrally located domain that avidly binds regulatory subunits (..

More Information

Publications102 found, 100 shown here

  1. Huang L, Wang L, Ma Y, Durick K, Perkins G, Deerinck T, et al. NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. J Cell Biol. 1999;145:951-9 pubmed
    ..Dual specificity AKAP1, (D-AKAP1) binds to both type I and type II regulatory subunits and has two NH2-terminal (N0 and N1) and two COOH-..
  2. Kapiloff M, Schillace R, Westphal A, Scott J. mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. J Cell Sci. 1999;112 ( Pt 16):2725-36 pubmed
  3. Furusawa M, Ohnishi T, Taira T, Iguchi Ariga S, Ariga H. AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase. J Biol Chem. 2001;276:36647-51 pubmed
    ..as a bait using a human HeLa cDNA library, and a clone encoding cAMP-dependent protein kinase anchor protein 149 (AKAP149), was obtained...
  4. Rogne M, Stokka A, Tasken K, Collas P, Küntziger T. Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. Hum Mol Genet. 2009;18:978-87 pubmed publisher
    A-kinase-anchoring protein 149 (AKAP149) is a membrane protein of the mitochondrial and endoplasmic reticulum/nuclear envelope network...
  5. Lemay J, Maidou Peindara P, Cancio R, Ennifar E, Coadou G, Maga G, et al. AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. J Mol Biol. 2008;383:783-96 pubmed publisher
    ..We show here that A-kinase anchoring protein 149 (AKAP149) interacts with HIV-1 reverse transcriptase (RT) in both the yeast two-hybrid system and human cells...
  6. Shepard R, Gouty S, Kassis H, Berenji A, Zhu W, Cox B, et al. Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA. Exp Neurol. 2018;309:160-168 pubmed publisher
    ..Our data suggest that HDAC-mediated targeting of BDNF and AKAP-dependent local signaling within VTA could provide novel therapeutics for prevention of later-life psychopathology.
  7. Bieluszewska A, Weglewska M, Bieluszewski T, Lesniewicz K, Poreba E. PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein. FEBS J. 2018;285:947-964 pubmed publisher
    ..and another DPY30-binding partner brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1), which is also AKAP domain-containing protein...
  8. Chabowska Kita A, Trabczynska A, Korytko A, Kaczmarek M, Kozak L. Low ambient temperature during early postnatal development fails to cause a permanent induction of brown adipocytes. FASEB J. 2015;29:3238-52 pubmed publisher
    ..g., Akap 12 and Ngfr)...
  9. Haidar M, Ramdani G, Kennedy E, Langsley G. PKA and Apicomplexan Parasite Diseases. Horm Metab Res. 2017;49:296-300 pubmed publisher
    ..signaling that are relevant to Plasmodium falciparum-infection of erythrocytes and present an update on AKAP targeting of PKA in PGE2 signaling via EP4 in Theileria annulata-infection of leukocytes and discuss cAMP-..
  10. Serrano M, Moreno M, Bassols J, Moreno Navarrete J, Ortega F, Ricart W, et al. Coxsackie and adenovirus receptor is increased in adipose tissue of obese subjects: a role for adenovirus infection?. J Clin Endocrinol Metab. 2015;100:1156-63 pubmed publisher
    ..26; P = .008) and percentage fat mass (r = 0.28; P = .004). In VAT, MGLL, FSP27, AKAP, omentin, TKT, S14, and FABP contributed independently to CAR mRNA variation after adjusting for age and body mass ..
  11. Kim H, Kim J, Jeong J, Han S, Kim K. Akap12 is essential for the morphogenesis of muscles involved in zebrafish locomotion. Differentiation. 2014;88:106-16 pubmed publisher
    ..This study found that the zebrafish A-kinase anchoring protein (akap)12 isoforms akap12α and akap12β are required for muscle morphogenesis and locomotor activity...
  12. Nystoriak M, Nieves Cintrón M, Patriarchi T, Buonarati O, Prada M, Morotti S, et al. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017;10: pubmed publisher
    ..2 channel activity and vasoconstriction by AKAP-targeted PKA upon exposure to increased glucose and in diabetes.
  13. Rigatti M, Le A, Gerber C, Moraru I, Dodge Kafka K. Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Cell Signal. 2015;27:1807-15 pubmed publisher
    ..Computational modeling revealed that this mode of interaction allows for small amounts of AKAP and PKA (100-200nM) to regulate the phosphorylation of large quantities of PLB (50μM)...
  14. Stott J, Barrese V, Suresh M, Masoodi S, Greenwood I. Investigating the Role of G Protein ?? in Kv7-Dependent Relaxations of the Rat Vasculature. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher
    ..4-AKAP (a-kinase anchoring protein) associations in a gallein-sensitive manner...
  15. Cserne Szappanos H, Muralidharan P, Ingley E, Petereit J, Millar A, Hool L. Identification of a novel cAMP dependent protein kinase A phosphorylation site on the human cardiac calcium channel. Sci Rep. 2017;7:15118 pubmed publisher
    ..A protein kinase A anchoring protein (AKAP) was not required...
  16. Brackley A, Gomez R, Guerrero K, Akopian A, Glucksman M, Du J, et al. A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation. Sci Rep. 2017;7:1842 pubmed publisher
    ..As a scaffolding protein for Protein Kinases A and C (PKA and PKC, respectively), AKAP facilitates phosphorylation and sensitization of TRPA1 in ex vivo sensory neuronal preparations...
  17. Bogard A, Tavalin S. Protein Kinase C (PKC)ζ Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation. Mol Pharmacol. 2015;88:728-35 pubmed publisher
    ..that ZIP potently disrupts PKCα interaction with the PKC-targeting protein A-kinase anchoring protein (AKAP) 79 and interferes with ionomycin-induced translocation of conventional PKC to the plasma membrane...
  18. Ding C, Xu G, Tang H, Zhu S, Zhao L, Ren H, et al. Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70. Oncotarget. 2015;6:15540-50 pubmed
    ..with the type II regulatory subunit of PKA (PKA-RIIα), acting as a novel protein kinase A anchoring protein (AKAP). In addition, RAI16 also interacted with heat shock protein 70 (HSP70) and 14-3-3θ...
  19. Moreno Navarrete J, Moreno M, Vidal M, Ortega F, Serrano M, Xifra G, et al. Deleted in breast cancer 1 plays a functional role in adipocyte differentiation. Am J Physiol Endocrinol Metab. 2015;308:E554-61 pubmed publisher
    ..lipogenic (FASN, ACACA), lipid droplet-associated genes (PLIN1, FSP27, ADRP, and TIP47), and lipolytic (ABDH5, AKAP, and PRKACA) genes but negatively associated with ADIPOQ in VAT...
  20. Chu D, Tao Y, Tasken K. OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes. Horm Metab Res. 2017;49:276-285 pubmed publisher
    ..recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1)...
  21. Diviani D, Osman H, Reggi E. A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection. J Cardiovasc Dev Dis. 2018;5: pubmed publisher
    ..b>AKAP-Lbc, a cardiac enriched anchoring protein, has been shown to act as a key coordinator of the activity of signaling ..
  22. Mack K, Fischer M. Disrupting sensitization of TRPV4. Neuroscience. 2017;352:1-8 pubmed publisher
    ..2 agonist, involvement of an A-kinase anchoring protein in TRPV4 activation was demonstrated by inhibition with AKAP inhibitor peptide Ht31. TRPV4 has substantial sequence similarity to TRPV1 in the range interacting with AKAP79...
  23. Shen J, Cooper D. AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex. Biochem J. 2013;455:47-56 pubmed publisher
    ..The cAMP formed is degraded by PDE4 (phosphodiesterase 4) activated by an AKAP-anchored PKA (protein kinase A). Calcineurin, a phosphatase bound to AKAP79, is not involved in this regulation...
  24. Muñoz Llancao P, de Gregorio C, Las Heras M, Meinohl C, Noorman K, Boddeke E, et al. Microtubule-regulating proteins and cAMP-dependent signaling in neuroblastoma differentiation. Cytoskeleton (Hoboken). 2017;74:143-158 pubmed publisher
    ..Moreover, disruption of the PKA-AKAP interaction reduced these morphometric parameters...
  25. Hiramoto K, Murata T, Shimizu K, Morita H, Inui M, Manganiello V, et al. Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells. Cell Signal. 2014;26:1807-17 pubmed publisher
    ..Invasion, but not growth, was stimulated by A-kinase anchor protein (AKAP) St-Ht31 inhibitory peptide...
  26. Sanderson J, Gorski J, Dell Acqua M. NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²⁺-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin. Neuron. 2016;89:1000-15 pubmed publisher
    ..Using knockin mice that are deficient in AKAP-anchoring of either PKA or the opposing phosphatase calcineurin, we found that CP-AMPARs are recruited to ..
  27. Zhang J, Carver C, Choveau F, Shapiro M. Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron. 2016;92:461-478 pubmed publisher
    ..or TRPV1 channels) and G protein-coupled receptors coupled by the scaffolding protein A-kinase-anchoring protein (AKAP)79/150. Some channels assembled as multi-channel supercomplexes...
  28. Torres Quesada O, Mayrhofer J, Stefan E. The many faces of compartmentalized PKA signalosomes. Cell Signal. 2017;37:1-11 pubmed publisher
    ..The AKAP-mediated clustering of cAMP and other second messenger sensing and interacting signaling components along with ..
  29. Reggi E, Diviani D. The role of A-kinase anchoring proteins in cancer development. Cell Signal. 2017;40:143-155 pubmed publisher
    ..Mutations or altered expression of AKAP coding genes results in unregulated signaling associated with oncogenesis, cancer maintenance, and metastasis...
  30. Hermann J, Skroblin P, Bertinetti D, Hanold L, von der Heide E, Wagener E, et al. Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein. Biochim Biophys Acta. 2015;1854:1667-75 pubmed publisher
    ..proteomics approach, we identified neurochondrin (neurite-outgrowth promoting protein) as a previously unidentified AKAP. Here, we show that neurochondrin interacts directly with PKA through a novel mechanism that involves two distinct ..
  31. Zhang Y, Chen Y, Gucek M, Xu H. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. EMBO J. 2016;35:1045-57 pubmed publisher
    ..Here, we describe a Drosophila AKAP protein, MDI that recruits a translation stimulator, La-related protein (Larp), to the mitochondrial outer membrane ..
  32. Li C, Le K, Kato J, Moss J, Vaughan M. Enhancement of ?-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals. Proc Natl Acad Sci U S A. 2016;113:5946-51 pubmed publisher
    ..BIG proteins also contain A-kinase anchoring protein (AKAP) sequences that can act as scaffolds for multimolecular assemblies that facilitate and limit cAMP signaling ..
  33. Tillo S, Xiong W, Takahashi M, Miao S, Andrade A, Fortin D, et al. Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates. Cell Rep. 2017;19:617-629 pubmed publisher
    ..We propose that activation-dependent association of PKA-C renders the membrane a unique PKA-signaling compartment. Constrained mobility of PKA-C may synergize with AKAP anchoring to determine specific PKA function in neurons.
  34. Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez K, Elkins J, et al. An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. PLoS ONE. 2018;13:e0191423 pubmed publisher
    ..The A-kinase anchoring protein, AKAP-Lbc, possesses GEF activity, specifically activates RhoA, and is expressed in primary renal inner medullary ..
  35. Authement M, Kodangattil J, Gouty S, Rusnak M, Symes A, Cox B, et al. Histone Deacetylase Inhibition Rescues Maternal Deprivation-Induced GABAergic Metaplasticity through Restoration of AKAP Signaling. Neuron. 2015;86:1240-52 pubmed publisher
    ..Histone deacetylase (HDAC) inhibition rescues GABAergic metaplasticity and normalizes AKAP signaling in MD animals...
  36. Nebel R, Kirschen J, Cai J, Woo Y, Cherian K, Abrahams B. Reciprocal Relationship between Head Size, an Autism Endophenotype, and Gene Dosage at 19p13.12 Points to AKAP8 and AKAP8L. PLoS ONE. 2015;10:e0129270 pubmed publisher
    ..candidate genes involved in regulation of head growth, an interesting finding given previous work implicating the AKAP gene family in autism...
  37. Jun Y, Park H, Lee Y, Kaang B, Lee J, Jang D. D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane. FEBS Lett. 2016;590:954-61 pubmed publisher
    Dual A-kinase anchoring protein 1a (D-AKAP1a, AKAP1) regulates cAMP signaling in mitochondria. However, it is not clear how D-AKAP1a is associated with mitochondria...
  38. Brackley A, Sarrami S, Gomez R, Guerrero K, Jeske N. Identification of a signaling cascade that maintains constitutive ?-opioid receptor incompetence in peripheral sensory neurons. J Biol Chem. 2017;292:8762-8772 pubmed publisher
    ..Protein kinase A-anchoring protein 79/150 (AKAP), residing at the plasma membrane in neurons, scaffolds PKA to target proteins to mediate downstream signal...
  39. King C, Gameiro S, Tessier T, Zhang A, Mymryk J. Mimicry of Cellular A Kinase-Anchoring Proteins Is a Conserved and Critical Function of E1A across Various Human Adenovirus Species. J Virol. 2018;92: pubmed publisher
    ..We show here that E1As from other species of HAdV also possess this viral AKAP (vAKAP) function and examine how they manipulate PKA...
  40. Baldwin T, Dessauer C. Function of Adenylyl Cyclase in Heart: the AKAP Connection. J Cardiovasc Dev Dis. 2018;5: pubmed publisher
    ..This review will summarize the distinct roles of AC isoforms in cardiac function and how interactions with AKAPs facilitate AC function, highlighting newly appreciated roles for lesser abundant AC isoforms. ..
  41. Raslan Z, Magwenzi S, Aburima A, Taskén K, Naseem K. Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3',5'-cyclic adenosine monophosphate-signaling pathway. J Thromb Haemost. 2015;13:1721-34 pubmed publisher
    ..Far Western blotting, immunoprecipitation, proximity ligation assay and cAMP pull-down we identified moesin as an AKAP that potentially localizes PKA-I to rafts...
  42. Bandje K, Naissant B, Bigey P, Lohezic M, Vayssières M, Blaud M, et al. Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum. Malar J. 2016;15:248 pubmed publisher
    ..Here, PfAKAL, an open reading frame of a potential AKAP-like protein in the P...
  43. Wehbi V, Tasken K. Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units. Front Immunol. 2016;7:222 pubmed publisher
    ..of effector T cells (Teff) acting through a proximal PKA/Csk/Lck pathway anchored via a scaffold consisting of the AKAP Ezrin holding PKA, the linker protein EBP50, and the anchoring protein phosphoprotein associated with ..
  44. Stover J, Farhang N, Berrett K, Gertz J, Lawrence B, Bowles R. CRISPR Epigenome Editing of AKAP150 in DRG Neurons Abolishes Degenerative IVD-Induced Neuronal Activation. Mol Ther. 2017;25:2014-2027 pubmed publisher
    ..trigger interleukin (IL)-6-induced increases in neuron activity to thermal stimuli, which is directly mediated by AKAP and enhanced by acidic pH...
  45. Ohgushi M, Minaguchi M, Sasai Y. Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells. Cell Stem Cell. 2015;17:448-61 pubmed publisher
    ..We found that the survival of hESCs depends on the small GTPase Rho and its activator AKAP-Lbc...
  46. Thakkar A, Aljameeli A, Thomas S, Shah G. A-kinase anchoring protein 2 is required for calcitonin-mediated invasion of cancer cells. Endocr Relat Cancer. 2016;23:1-14 pubmed publisher
    ..actions were abolished by st-Ht31 inhibitory peptide suggesting the involvement of an A-kinase anchoring protein (AKAP) in CT action...
  47. Wild A, Dell Acqua M. Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders. Pharmacol Ther. 2018;185:99-121 pubmed publisher
    ..A number of essential neurological processes are known to critically depend on AKAP-directed signaling and an understanding of the role AKAPs play in nervous system disorders has emerged in recent ..
  48. Kjällquist U, Erlandsson R, Tobin N, Alkodsi A, Ullah I, Stålhammar G, et al. Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs). BMC Cancer. 2018;18:174 pubmed publisher
    ..expression from the metastatic lesions and a primary breast cancer data set to study the gene expression of the AKAP gene family. We report that somatic mutations in A-kinase anchoring proteins are enriched in metastatic lesions...
  49. Bendzunas N, Dörfler S, Autenrieth K, Bertinetti D, Machal E, Kennedy E, et al. Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg Med Chem. 2018;26:1174-1178 pubmed publisher
    ..Although numerous AKAP disruptors have previously been identified that can inhibit either RI- or RII-selective AKAPs, no AKAP disruptors ..
  50. Vizel R, Hillman P, Ickowicz D, Breitbart H. AKAP3 degradation in sperm capacitation is regulated by its tyrosine phosphorylation. Biochim Biophys Acta. 2015;1850:1912-20 pubmed publisher
    The A-kinase anchoring protein (AKAP) family is essential for sperm motility, capacitation and the acrosome reaction. PKA-dependent protein tyrosine phosphorylation occurs in mammalian sperm capacitation including AKAP3...
  51. Araujo C, Hermidorff M, Amâncio G, Lemos D, Silva M, de Assis L, et al. Rapid effects of aldosterone in primary cultures of cardiomyocytes - do they suggest the existence of a membrane-bound receptor?. J Recept Signal Transduct Res. 2016;36:435-44 pubmed publisher
    ..Next, we have evaluated the role of A-kinase anchor proteins (AKAP) in the aldosterone-induced hypertrophic response...
  52. Fertig B, Baillie G. PDE4-Mediated cAMP Signalling. J Cardiovasc Dev Dis. 2018;5: pubmed publisher
    ..which often include a cAMP effector, such as PKA, its substrate, PDE4 and an anchoring protein such as an AKAP. Studies described in the present review highlight the importance of this relationship for individual cardiac PKA ..
  53. Schiattarella G, Cattaneo F, Pironti G, Magliulo F, Carotenuto G, Pirozzi M, et al. Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis. PLoS ONE. 2016;11:e0154076 pubmed publisher
    ..Under conditions of hypoxia, mitochondrial AKAP121 undergoes proteolytic degradation mediated, at least in part, by the E3 ubiquitin ligase Seven In-Absentia ..
  54. King C, Cohen M, Fonseca G, Dirk B, Dikeakos J, Mymryk J. Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein. PLoS Pathog. 2016;12:e1005621 pubmed publisher
    ..We show that E1A structurally and functionally mimics a cellular A-kinase anchoring protein (AKAP)...
  55. Suryavanshi S, Jadhav S, Anderson K, Katsonis P, Lichtarge O, McConnell B. Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling. Am J Physiol Heart Circ Physiol. 2018;315:H109-H121 pubmed publisher
    ..e., A-kinase anchoring proteins (AKAPs). Muscle-specific AKAP (mAKAP) partly regulates cardiac cAMP/PKA signaling by binding to PKA and phosphodiesterase 4D3 (PDE4D3), among ..
  56. Ranganathan G, Unal R, Pokrovskaya I, Tripathi P, Rotter J, Goodarzi M, et al. The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation. Atherosclerosis. 2012;221:143-7 pubmed publisher
    ..and in response to the use of components of the RNA binding complex (PKA C and R subunits, and KH region of AKAP149)...
  57. Gorshkov K, Mehta S, Ramamurthy S, Ronnett G, Zhou F, Zhang J. AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat Chem Biol. 2017;13:425-431 pubmed publisher
    ..Our results provide new evidence for a local negative-feedback loop, assembled by AKAPs, for the precise control of a growth-stage-dependent cAMP gradient to ensure proper axon growth. ..
  58. Szteyn K, Rowan M, Gomez R, Du J, Carlton S, Jeske N. A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons. Pain. 2015;156:2364-72 pubmed publisher
    ..In dissociated primary afferent neurons, mGluR5 activation increases TRPV1 responses in an AKAP-dependent manner through a mechanism that induces AKAP association with TRPV1...
  59. Martin B, Deerinck T, Ellisman M, Taylor S, Tsien R. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chem Biol. 2007;14:1031-42 pubmed
    ..Overall, effective separation of type I PKA is substrate dependent, whereas type II PKA dissociation relies on autophosphorylation. ..
  60. Tobío A, Fernández Araujo A, Alfonso A, Botana L. Role of yessotoxin in calcium and cAMP-crosstalks in primary and K-562 human lymphocytes: the effect is mediated by anchor kinase A mitochondrial proteins. J Cell Biochem. 2012;113:3752-61 pubmed publisher
    ..On the one hand, in human fresh lymphocytes, YTX increases AKAP149 cytosolic expression...
  61. Rinaldi L, Sepe M, Delle Donne R, Conte K, Arcella A, Borzacchiello D, et al. Mitochondrial AKAP1 supports mTOR pathway and tumor growth. Cell Death Dis. 2017;8:e2842 pubmed publisher
    ..b>AKAP1 scaffolding protein integrates cAMP and src signaling on mitochondria, regulating organelle biogenesis, oxidative ..
  62. Lester L, Scott J. Anchoring and scaffold proteins for kinases and phosphatases. Recent Prog Horm Res. 1997;52:409-29; discussion 429-30 pubmed
    ..the functional significance of PKA anchoring inside cells and have begun to be established by that disruption RII/AKAP interaction in vivo has concomitant effects on certain PKA-mediated phosphorylation events...
  63. Ruppelt A, Mosenden R, Grönholm M, Aandahl E, Tobin D, Carlson C, et al. Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J Immunol. 2007;179:5159-68 pubmed
    ..Finally, small interfering RNA-mediated knockdown of Ezrin abrogates cAMP regulation of IL-2. We propose that Ezrin is essential in the assembly of the cAMP-mediated regulatory pathway that modulates T cell immune responses. ..
  64. Warren K, Warrilow D, Meredith L, Harrich D. Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription. Viruses. 2009;1:873-94 pubmed publisher
    ..In addition, recent studies implicate the cellular proteins HuR, AKAP149, and DNA topoisomerase I in reverse transcription through an interaction with RT...
  65. Götz F, Roske Y, Schulz M, Autenrieth K, Bertinetti D, Faelber K, et al. AKAP18:PKA-RII? structure reveals crucial anchor points for recognition of regulatory subunits of PKA. Biochem J. 2016;473:1881-94 pubmed publisher
    ..Thus we report a novel mechanism governing interactions of AKAPs with PKA. The sequence specificity of each AKAP around the anchor points and the requirement of these points for the tight binding of PKA allow the development of ..
  66. Khan A, Munir M, Aiman S, Wadood A, Khan A. The in silico identification of small molecules for protein-protein interaction inhibition in AKAP-Lbc-RhoA signaling complex. Comput Biol Chem. 2017;67:84-91 pubmed publisher
    ..The A-Kinase Anchoring Protein, i.e. AKAP-Lbc, catalyses nucleotide exchange on RhoA and is involved in cardiac repolarization...
  67. Michel J, Scott J. AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol. 2002;42:235-57 pubmed
    ..This review details the most recent advances in our understanding of the various biological functions dependent upon AKAP-anchored signaling complexes.
  68. Carlson C, Ruppelt A, Tasken K. A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. J Mol Biol. 2003;327:609-18 pubmed
    ..as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain of AKAP149/D-AKAP1. Furthermore, an RIbeta:AKAP149 complex was identified following introduction of RIbeta into HEK293 cells...
  69. Flynn R, Altier C. A macromolecular trafficking complex composed of ??-adrenergic receptors, A-Kinase Anchoring Proteins and L-type calcium channels. J Recept Signal Transduct Res. 2013;33:172-6 pubmed publisher
    ..2 channel surface expression. Here we review the molecular mechanisms of ?2AR/AKAP/L-type channel interactions and trafficking.
  70. Hedrick E, Agarwal E, Leiphrakpam P, Haferbier K, Brattain M, Chowdhury S. Differential PKA activation and AKAP association determines cell fate in cancer cells. J Mol Signal. 2013;8:10 pubmed publisher
    ..The cAMP independent PKA activation pathway is dependent upon mitochondrial AKAP149 for its apoptotic functions...
  71. Caso S, Maric D, Arambasic M, Cotecchia S, Diviani D. AKAP-Lbc mediates protection against doxorubicin-induced cardiomyocyte toxicity. Biochim Biophys Acta Mol Cell Res. 2017;1864:2336-2346 pubmed publisher
    ..Importantly, our results indicate that AKAP-Lbc is critical for transducing protective signals downstream of ?1-ARs...
  72. García Pelagio K, Chen L, Joca H, Ward C, Jonathan Lederer W, Bloch R. Absence of synemin in mice causes structural and functional abnormalities in heart. J Mol Cell Cardiol. 2018;114:354-363 pubmed publisher
    ..It also acts as an A-kinase anchoring protein (AKAP). In murine skeletal muscle, the absence of synemin causes a mild myopathy...
  73. Xie G, Raufman J. Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1051-8 pubmed
    ..We determined whether an AKAP-signaling protein complex exists in chief cells and whether this modulates secretion...
  74. Chaudhry A, Zhang C, Granneman J. Characterization of RII(beta) and D-AKAP1 in differentiated adipocytes. Am J Physiol Cell Physiol. 2002;282:C205-12 pubmed
    ..Immunoblotting and nuclease protection analysis of C3H/10T1/2 cellular extracts identified this band as D-AKAP1/S-AKAP84, a putative AKAP...
  75. Furusawa M, Taira T, Iguchi Ariga S, Ariga H. AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. J Biol Chem. 2002;277:50885-92 pubmed
    ..reported that a novel c-Myc-binding protein, AMY-1, binds to cAMP-dependent protein kinase-anchoring protein 149 (AKAP149) and its splicing variant, AKAP84 and is localized in the mitochondria in a complex with RII, a regulatory ..
  76. Potet F, Scott J, Mohammad Panah R, Escande D, Baro I. AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex. Am J Physiol Heart Circ Physiol. 2001;280:H2038-45 pubmed
    ..In contrast, coexpression of the neuronal A kinase anchoring protein (AKAP)79, a fragment of a cardiac AKAP (mAKAP), or cardiac AKAP15/18 restored cAMP regulation of KvLQT1/IsK complexes ..
  77. Yukitake H, Furusawa M, Taira T, Iguchi Ariga S, Ariga H. AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. J Biol Chem. 2002;277:45480-92 pubmed
    ..AMY-1 was also found to be associated with protein kinase A anchor protein 84/149 (S-AKAP84/AKAP149) in the mitochondria in somatic cells and sperm, suggesting that it plays a role in spermatogenesis...
  78. Cardone L, Carlucci A, Affaitati A, Livigni A, DeCristofaro T, Garbi C, et al. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Mol Cell Biol. 2004;24:4613-26 pubmed
    A-kinase anchor protein 121 (AKAP121) and its spliced isoform AKAP84 anchor protein kinase A (PKA) to the outer membrane of mitochondria, focusing and enhancing cyclic AMP signal transduction to the organelle...
  79. Fernández Araujo A, Tobío A, Alfonso A, Botana L. Role of AKAP 149-PKA-PDE4A complex in cell survival and cell differentiation processes. Int J Biochem Cell Biol. 2014;53:89-101 pubmed publisher
    ..In this paper the cellular distribution of the mitochondrial AKAP 149-PKA-PDE4A complex and its implications in the cell death induced by YTX treatment, a known PDE modulator, was ..
  80. Bachmann V, Mayrhofer J, Ilouz R, Tschaikner P, Raffeiner P, Röck R, et al. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proc Natl Acad Sci U S A. 2016;113:7786-91 pubmed publisher
    ..We show that Gpr161 functions as a selective high-affinity AKAP for type I PKA regulatory subunits (RI)...
  81. Dema A, Schröter M, Perets E, Skroblin P, Moutty M, Deák V, et al. The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3? Interaction Protein (GSKIP) Regulates ?-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3?. J Biol Chem. 2016;291:19618-30 pubmed publisher
    The A-kinase anchoring protein (AKAP) GSK3? interaction protein (GSKIP) is a cytosolic scaffolding protein binding protein kinase A (PKA) and glycogen synthase kinase 3? (GSK3?). Here we show that both the AKAP function of GSKIP, i.e...
  82. Islam A, Jones H, Hiroi T, Lam J, Zhang J, Moss J, et al. cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to BIG2. J Biol Chem. 2008;283:25364-71 pubmed publisher
    ..Here, we assessed the role of BIG2 A kinase-anchoring protein (AKAP) domains in the regulation of TNFR1 exosome-like vesicle release from human vascular endothelial cells...
  83. Burmeister B, Taglieri D, Wang L, Carnegie G. Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart. J Biol Chem. 2012;287:40535-46 pubmed publisher
    b>AKAP-Lbc is a scaffold protein that coordinates cardiac hypertrophic signaling. AKAP-Lbc interacts with Shp2, facilitating its regulation by PKA. AKAP-Lbc integrates PKA and Shp2 signaling in the heart...
  84. Hoffman N, Parker B, Chaudhuri R, Fisher Wellman K, Kleinert M, Humphrey S, et al. Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab. 2015;22:922-35 pubmed publisher
    ..We validated eight predicted AMPK substrates, including AKAP1, using targeted phosphoproteomics...
  85. Czachor A, Failla A, Lockey R, Kolliputi N. Pivotal role of AKAP121 in mitochondrial physiology. Am J Physiol Cell Physiol. 2016;310:C625-8 pubmed publisher
    In this Perspective, we discuss some recent developments in the study of the mitochondrial scaffolding protein AKAP121 (also known as AKAP1, or AKAP149 as the human homolog), with an emphasis on its role in mitochondrial physiology...
  86. Hu Z, Wang X, Guo W, Xie L, Huang Y, Liu Y, et al. Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells. Oncotarget. 2016;7:11733-43 pubmed publisher
    ..cancer (CRC) cell proliferation, invasion and metastasis in vitro and in vivo by increasing expression of AKAP-9...
  87. Kurihara K, Nakanishi N, Ueha T. Regulation of Na(+)-K(+)-ATPase by cAMP-dependent protein kinase anchored on membrane via its anchoring protein. Am J Physiol Cell Physiol. 2000;279:C1516-27 pubmed
    ..phosphorylation by membrane-bound endogenous PKA, indicating an involvement of A-kinase anchoring protein (AKAP)...
  88. Carlucci A, Adornetto A, Scorziello A, Viggiano D, Foca M, Cuomo O, et al. Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia. EMBO J. 2008;27:1073-84 pubmed publisher
    A-kinase anchor protein 121 (AKAP121) assembles a multivalent signalling complex on the outer mitochondrial membrane that controls persistence and amplitude of cAMP and src signalling to mitochondria, and plays an essential role in ..
  89. Dukic A, Haugen L, Pidoux G, Leithe E, Bakke O, Tasken K. A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells. Cell Signal. 2017;32:1-11 pubmed publisher
    ..Ezrin is a membrane associated protein that can serve as an A-kinase anchoring protein (AKAP) and hold an anchored pool of PKA...
  90. Woolfrey K, O Leary H, Goodell D, Robertson H, Horne E, Coultrap S, et al. CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem. 2018;293:1551-1567 pubmed publisher
    ..accumulation or removal, respectively, of the AMPA-receptor regulatory scaffold protein A-kinase anchoring protein (AKAP) 79/150...
  91. Grozdanov P, Stocco D. Short RNA molecules with high binding affinity to the KH motif of A-kinase anchoring protein 1 (AKAP1): implications for the regulation of steroidogenesis. Mol Endocrinol. 2012;26:2104-17 pubmed publisher
    ..nuclear ribonucleoprotein K-homology (KH) motif of the mitochondrial scaffold A-kinase anchoring protein 1 (AKAP1) in vitro with a moderate affinity as measured by EMSAs...
  92. Li B, Wang W, Li Z, Chen Z, Zhi X, Xu J, et al. MicroRNA-148a-3p enhances cisplatin cytotoxicity in gastric cancer through mitochondrial fission induction and cyto-protective autophagy suppression. Cancer Lett. 2017;410:212-227 pubmed publisher
    ..sensitized CDDP-resistant cells to CDDP treatment through promoting mitochondrial fission and decreasing AKAP1 expression level; 3) AKAP1 played a novel role in CDDP resistance by inhibiting P53-mediated DRP1 ..