Gene Symbol: AK5
Description: adenylate kinase 5
Alias: AK6, adenylate kinase isoenzyme 5, AK 5, ATP-AMP transphosphorylase 5, adenylate kinase 6
Species: human
Products:     AK5

Top Publications

  1. Zoccarato M, Valeggia S, Zuliani L, Gastaldi M, Mariotto S, Franciotta D, et al. Conventional brain MRI features distinguishing limbic encephalitis from mesial temporal glioma. Neuroradiology. 2019;: pubmed publisher
    ..from the LE group were correctly recognized; one additional patient with mesial temporal hyperintensity with anti-AK5 abs LE was wrongly diagnosed as having a tumor...
  2. Mandáková T, Lysak M. Healthy Roots and Leaves: Comparative Genome Structure of Horseradish and Watercress. Plant Physiol. 2019;179:66-73 pubmed publisher
    ..the Ancestral Crucifer Karyotype (n = 8), which, however, contained two unique translocation chromosomes (AK6/8 and AK8/6). Except for a 2...
  3. Drakou C, Malekkou A, Hayes J, Lederer C, Leonidas D, Oikonomakos N, et al. hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. Proteins. 2012;80:206-20 pubmed publisher
    ..hCINAP has previously been designated as an adenylate kinase (AK6), but is very atypical as it exhibits unusually broad substrate specificity, structural features characteristic of ..
  4. Ansoleaga B, Jové M, Schlüter A, Garcia Esparcia P, Moreno J, Pujol A, et al. Deregulation of purine metabolism in Alzheimer's disease. Neurobiol Aging. 2015;36:68-80 pubmed publisher
    ..APRT, DGUOK, POLR3B, ENTPD3, AK5, NME1, NME3, NME5, NME7, and ENTPD2 messenger RNAs were deregulated, with regional variations, in AD cases when ..
  5. Bai D, Zhang J, Li T, Hang R, Liu Y, Tian Y, et al. The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nat Commun. 2016;7:12310 pubmed publisher
    ..Here we show that hCINAP (also named AK6) is required for human 18S rRNA processing and 40S subunit assembly...
  6. Do L, Chanson E, Desestret V, Joubert B, Ducray F, Brugière S, et al. Characteristics in limbic encephalitis with anti-adenylate kinase 5 autoantibodies. Neurology. 2017;88:514-524 pubmed publisher
    To report 10 patients with limbic encephalitis (LE) and adenylate kinase 5 autoantibodies (AK5-Abs)...
  7. Ng A, Kramer J, Centurion A, Dalmau J, Huang E, Cotter J, et al. Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis. J Neuroimmunol. 2015;287:31-5 pubmed publisher
    ..Adenylate kinase 5 (AK5) is a nucleoside monophosphate kinase vital for neuronal-specific metabolism and is located intracellularly in the ..
  8. Van Rompay A, Johansson M, Karlsson A. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. Eur J Biochem. 1999;261:509-17 pubmed
    ..Based on the substrate specificity and the sequence similarity with the previously identified human adenylate kinases, we have named this novel enzyme adenylate kinase 5. ..
  9. Solaroli N, Panayiotou C, Johansson M, Karlsson A. Identification of two active functional domains of human adenylate kinase 5. FEBS Lett. 2009;583:2872-6 pubmed publisher
    A full length cDNA that partially corresponded to human adenylate kinase 5 (AK5) was identified and shown to encode for two separate domains...

More Information


  1. Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int J Biochem Cell Biol. 2013;45:925-31 pubmed publisher
    ..These enzymes are accordingly suggested to be regarded as nucleoside mono- and diphosphate kinases with catalytic activities possibly determined by local substrate concentrations. ..
  2. Lai Y, Hu X, Chen G, Wang X, Zhu B. Down-regulation of adenylate kinase 5 in temporal lobe epilepsy patients and rat model. J Neurol Sci. 2016;366:20-26 pubmed publisher
    Adenylate kinase 5 (AK5) is one member of the AK family and plays a critical role in maintaining cellular homeostasis. Different from the other AKs, AK5 is almost exclusively expressed in the brain...