Ajuba

Summary

Gene Symbol: Ajuba
Description: ajuba LIM protein
Alias: JUB, LIM domain-containing protein ajuba, jub, ajuba homolog
Species: human
Products:     Ajuba

Top Publications

  1. Hou Z, Peng H, Ayyanathan K, Yan K, Langer E, Longmore G, et al. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol. 2008;28:3198-207 pubmed publisher
    ..Previously we demonstrated that the AJUBA family of LIM proteins function as corepressors for SNAIL and, as such, may serve as a platform for the assembly ..
  2. Kanungo J, Pratt S, Marie H, Longmore G. Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions. Mol Biol Cell. 2000;11:3299-313 pubmed
    ..Here we demonstrate that the family member Ajuba was recruited to the cell surface of embryonal cells, upon aggregate formation, at sites of cell-cell contact...
  3. Pratt S, Epple H, Ward M, Feng Y, Braga V, Longmore G. The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol. 2005;168:813-24 pubmed
    ..The Ajuba/Zyxin family of LIM proteins are components of cellular adhesive complexes...
  4. Haraguchi K, Ohsugi M, Abe Y, Semba K, Akiyama T, Yamamoto T. Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Oncogene. 2008;27:274-84 pubmed
    ..Here, we report the identification of Ajuba as a negative regulator of the Wnt signaling pathway...
  5. Langer E, Feng Y, Zhaoyuan H, Rauscher F, Kroll K, Longmore G. Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell. 2008;14:424-36 pubmed publisher
    ..Here, we identify the Ajuba family of LIM proteins as functional corepressors of the Snail family via an interaction with the SNAG domain...
  6. Marie H, Pratt S, Betson M, Epple H, Kittler J, Meek L, et al. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem. 2003;278:1220-8 pubmed
    ..Here we show that, in primary keratinocytes, the LIM domain protein Ajuba is recruited to cadherin-dependent cell-cell adhesive complexes in a regulated manner...
  7. Hou Z, Peng H, White D, Negorev D, Maul G, Feng Y, et al. LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling. Proc Natl Acad Sci U S A. 2010;107:2938-43 pubmed publisher
    ..Here, we describe the identification of the multiple LIM domain protein Ajuba as a unique corepressor for a subset of nuclear hormone receptors...
  8. Montoya Durango D, Velu C, Kazanjian A, Rojas M, Jay C, Longmore G, et al. Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. J Biol Chem. 2008;283:32056-65 pubmed publisher
    Growth factor independent-1 (Gfi1) is a zinc finger protein with a SNAG-transcriptional repressor domain. Ajuba is a LIM domain protein that shuttles between the cytoplasm and the nucleus...
  9. Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell. 2003;114:585-98 pubmed
    ..A two-hybrid screen identified the LIM protein Ajuba as an Aurora-A binding protein...

More Information

Publications69

  1. Kisseleva M, Feng Y, Ward M, Song C, Anderson R, Longmore G. The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. Mol Cell Biol. 2005;25:3956-66 pubmed
    ..Here we show that the LIM protein Ajuba contributes to the cellular regulation of PI(4,5)P2 levels by interacting with and activating the enzymatic ..
  2. Goyal R, Lin P, Kanungo J, Payne A, Muslin A, Longmore G. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999;19:4379-89 pubmed
    ..We have identified and characterized a new LIM protein, Ajuba. Although predominantly a cytosolic protein, in contrast to other like proteins, it did not localize to sites of ..
  3. Lang T, Ding X, Kong L, Zhou X, Zhang Z, Ju H, et al. NFATC2 is a novel therapeutic target for colorectal cancer stem cells. Onco Targets Ther. 2018;11:6911-6924 pubmed publisher
    ..Mechanistic analysis indicated that NFATC2 upregulates the expression of AJUBA, downregulates the phosphorylation level of YAP, and therefore activates the transcriptional activities of YAP and ..
  4. Alégot H, Markosian C, Rauskolb C, Yang J, Kirichenko E, Wang Y, et al. Recruitment of Jub by α-catenin promotes Yki activity and Drosophila wing growth. J Cell Sci. 2019;132: pubmed publisher
    ..for the biomechanical regulation of YAP proteins have been described, including tension-dependent recruitment of Ajuba family proteins, which inhibit kinases that inactivate YAP proteins, to adherens junctions...
  5. Li H, Fu L, Liu B, Lin X, Dong Q, Wang E. Ajuba overexpression regulates mitochondrial potential and glucose uptake through YAP/Bcl-xL/GLUT1 in human gastric cancer. Gene. 2019;693:16-24 pubmed publisher
    b>Ajuba dysregulation has been reported in several human cancers. However, its expression patterns and biological roles in human gastric cancers have not yet been characterized...
  6. Tsuneki M, Hardee S, Michaud M, Morotti R, Lavik E, Madri J. A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway. Lab Invest. 2015;95:765-80 pubmed publisher
    ..phase to an involuted phase, both the murine implants and human biopsy tissue exhibit reduced expression of Ajuba, YAP, and Survivin labeling as they progressed over time...
  7. Moreno Uribe L, Ray A, Blanchette D, Dawson D, Southard T. Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion. Orthod Craniofac Res. 2015;18 Suppl 1:100-8 pubmed publisher
    ..soft-tissue facial height and width variation in Class II malocclusion and test for correlations with genes HMGA2, AJUBA, and ADK...
  8. Lange A, Sridharan A, Xu Y, Stripp B, Perl A, Whitsett J. Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung. J Mol Cell Biol. 2015;7:35-47 pubmed publisher
    ..expression of YAP regulated transcriptional targets controlling cell proliferation and differentiation, including Ajuba LIM protein. Ajuba was required for the effects of YAP on cell proliferation in vitro...
  9. Fowler S, Maguin P, Kalan S, Loayza D. LIM Protein Ajuba associates with the RPA complex through direct cell cycle-dependent interaction with the RPA70 subunit. Sci Rep. 2018;8:9536 pubmed publisher
    ..We have previously shown that the LIM protein Ajuba associates with RPA, and that depletion of Ajuba leads to potent activation of ATR...
  10. Zhang L, Zhou Y, Cheng C, Cui H, Cheng L, Kong P, et al. Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. Am J Hum Genet. 2015;96:597-611 pubmed publisher
    ..In our combined cohort, we identified frequent inactivating mutations in AJUBA, ZNF750, and PTCH1 and the chromatin-remodeling genes CREBBP and BAP1, in addition to known mutations...
  11. Willems E, Dedobbeleer M, Digregorio M, Lombard A, Goffart N, Lumapat P, et al. Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration. Oncogene. 2019;38:73-87 pubmed publisher
    ..Moreover, the CXCL12-ERK1/2 signaling induces the expression of Ajuba, the main cofactor of AurA, which allows the auto-phosphorylation of AurA...
  12. Gao Y, Chen Z, Li J, Hu X, Shi X, Sun Z, et al. Genetic landscape of esophageal squamous cell carcinoma. Nat Genet. 2014;46:1097-102 pubmed publisher
    ..The Hippo and Notch pathways were dysregulated by mutations in FAT1, FAT2, FAT3 or FAT4 (27%) or AJUBA (JUB; 7%) and NOTCH1, NOTCH2 or NOTCH3 (22%) or FBXW7 (5%), respectively...
  13. Tsuneki M, Madri J. Adhesion molecule-mediated hippo pathway modulates hemangioendothelioma cell behavior. Mol Cell Biol. 2014;34:4485-99 pubmed publisher
    ..We demonstrated reduced adherens junction molecule (CD31 and VE-cadherin) expression, increased survivin and Ajuba expression, and a reduction in Hippo pathway signaling resulting in increased proliferation and decreased ..
  14. Pickering C, Zhou J, Lee J, Drummond J, Peng S, Saade R, et al. Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res. 2014;20:6582-92 pubmed publisher
    ..23 candidate drivers were identified, including the well-known cancer-associated genes TP53, CDKN2A, NOTCH1, AJUBA, HRAS, CASP8, FAT1, and KMT2C (MLL3)...
  15. Gaspar P, Holder M, Aerne B, Janody F, Tapon N. Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth. Curr Biol. 2015;25:679-689 pubmed publisher
    ..The actin-associated LIM proteins Zyxin (Zyx) and Ajuba (Jub) have been linked to the control of tissue growth via regulation of Hpo signaling, but the study of Zyx has ..
  16. Razzell W, Bustillo M, Zallen J. The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis. J Cell Biol. 2018;217:3715-3730 pubmed publisher
    ..We show that the LIM-domain protein Ajuba is recruited to adherens junctions in a tension-dependent fashion during axis elongation...
  17. Chu C, Xiang B, Ossipova O, Ioannou A, Sokol S. The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure. J Cell Sci. 2018;131: pubmed publisher
    b>Ajuba family proteins are implicated in the assembly of cell junctions and have been reported to antagonize Hippo signaling in response to cytoskeletal tension...
  18. Liu M, Jiang K, Lin G, Liu P, Yan Y, Ye T, et al. Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation. J Exp Clin Cancer Res. 2018;37:165 pubmed publisher
    ..The LIM domain protein Ajuba regulates β-catenin and YAP signaling and is implicated in tumorigenesis...
  19. La X, Zhang L, Li H, Li Z, Song G, Yang P, et al. Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways. Oncotarget. 2018;9:15464-15479 pubmed publisher
    ..Mechanistically, Ajuba is able to interact with GRP78...
  20. Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, Suzuki Y, et al. Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. Gastroenterology. 2016;150:1171-1182 pubmed publisher
    ..FBXW7); epigenetic processes (MLL2, EP300, CREBBP, TET2); and the NOTCH (NOTCH1, NOTCH3), WNT (FAT1, YAP1, AJUBA) and receptor-tyrosine kinase-phosphoinositide 3-kinase signaling pathways (PIK3CA, EGFR, ERBB2)...
  21. Bridge K, Shah K, Li Y, Foxler D, Wong S, Miller D, et al. Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins. Cell Rep. 2017;20:173-187 pubmed publisher
    ..The switch to AGO3 utilization occurs due to the presence of a glutamic acid residue (E390) on the interaction interface, which allows AGO3 to bind to LIMD1, AJUBA, and WTIP irrespective of Akt signaling.
  22. Enomoto M, Kizawa D, Ohsawa S, Igaki T. JNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity. Dev Biol. 2015;403:162-71 pubmed publisher
    ..Ras, JNK signaling enhances Yki activation by accumulating F-actin through the activity of the LIM domain protein Ajuba, thereby promoting tissue growth...
  23. Schimizzi G, Longmore G. Ajuba proteins. Curr Biol. 2015;25:R445-6 pubmed publisher
    Schimizzi and Longmore summarise what we know about Ajuba LIM-domain proteins and their various subcellular roles.
  24. Fan H, Dong W, Li Q, Zou X, Zhang Y, Wang J, et al. Ajuba Preferentially Binds LXRα/RXRγ Heterodimer to Enhance LXR Target Gene Expression in Liver Cells. Mol Endocrinol. 2015;29:1608-18 pubmed publisher
    ..Here, we report that the LIM protein Ajuba binds to the hinge and the ligand binding domains of LXRα via its C-terminal tandem LIM motifs and enhances LXR ..
  25. Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine K. Tension-dependent regulation of mammalian Hippo signaling through LIMD1. J Cell Sci. 2018;131: pubmed publisher
    ..We show that all three mammalian Ajuba family proteins - AJUBA, LIMD1 and WTIP - exhibit tension-dependent localization to adherens junctions, and that ..
  26. Sun S, Reddy B, Irvine K. Localization of Hippo signalling complexes and Warts activation in vivo. Nat Commun. 2015;6:8402 pubmed publisher
    ..These complexes are reorganized on Hippo pathway activation, when Warts shifts from associating with its inhibitor Jub to its activator Expanded, and Hippo concentrates at Salvador sites...
  27. Mandaviya P, Aïssi D, Dekkers K, Joehanes R, Kasela S, Truong V, et al. Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis. Epigenomics. 2017;9:1403-1422 pubmed publisher
    ..Three differentially methylated positions cg21607669 (SLC27A1), cg26382848 (AJUBA) and cg10701000 (KCNMA1) at chromosome 19, 14 and 10, respectively, were significantly associated with Hcy...
  28. Li Q, Peng H, Fan H, Zou X, Liu Q, Zhang Y, et al. The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction. Cell Death Differ. 2016;23:158-68 pubmed publisher
    ..Here, we report Ajuba is an important regulator of adipocyte differentiation by functioning as an obligate co-activator of PPARγ...
  29. Yang D, Hou T, Li L, Chu Y, Zhou F, Xu Y, et al. Smad1 promotes colorectal cancer cell migration through Ajuba transactivation. Oncotarget. 2017;8:110415-110425 pubmed publisher
    ..Here, we demonstrate that Smad1 promotes migration of colorectal cancer (CRC) cells by inducing Snail and Ajuba expression simultaneously, but no apparent effect on Twist1 expression...
  30. Huang D, Li X, Sun L, Huang P, Ying H, Wang H, et al. Regulation of Hippo signalling by p38 signalling. J Mol Cell Biol. 2016;8:328-37 pubmed publisher
    ..further demonstrate that the Mekk1-Lic-p38b cascade inhibits Hippo signalling by promoting F-actin accumulation and Jub phosphorylation...
  31. Pan Y, Heemskerk I, Ibar C, Shraiman B, Irvine K. Differential growth triggers mechanical feedback that elevates Hippo signaling. Proc Natl Acad Sci U S A. 2016;113:E6974-E6983 pubmed publisher
    ..This reduced tension modulates a biomechanical Hippo pathway, decreasing recruitment of Ajuba LIM protein and the Hippo pathway kinase Warts, and decreasing the activity of the growth-promoting transcription ..
  32. Meserve J, Duronio R. Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage. Development. 2015;142:2740-51 pubmed publisher
    ..b>Ajuba, an upstream regulator of Hippo signaling that functions as a sensor of epithelial integrity, is also required for ..
  33. Shao Y, Li J, Ge R, Zhong L, Irwin D, Murphy R, et al. Genetic adaptations of the plateau zokor in high-elevation burrows. Sci Rep. 2015;5:17262 pubmed publisher
    ..to hypoxia, oxygen homeostasis and erythrocyte homeostasis) are significantly enriched, are two genes, EPAS1 and AJUBA, involved in the response to hypoxia, where the parallel evolved sites are at positions that are highly conserved ..
  34. Jagannathan R, Schimizzi G, Zhang K, Loza A, Yabuta N, Nojima H, et al. AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol. Mol Cell Biol. 2016;36:2526-42 pubmed publisher
    ..The members of the AJUBA family of LIM proteins are negative regulators of the Hippo pathway...
  35. Horie M, Saito A, Ohshima M, Suzuki H, Nagase T. YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer. Cancer Sci. 2016;107:1755-1766 pubmed publisher
    ..pattern in many SCLC cell lines, and microarray analyses revealed a subset of genes regulated by YAP, including Ajuba LIM protein (AJUBA). AJUBA also contributed to cell morphology regulation...
  36. Gleber Netto F, Zhao M, Trivedi S, Wang J, Jasser S, McDowell C, et al. Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer. 2018;124:84-94 pubmed publisher
    ..DNA libraries covering exons of 18 genes frequently mutated in HNSCC (AJUBA, CASP8, CCND1, CDKN2A, EGFR, FAT1, FBXW7, HLA-A, HRAS, KEAP1, NFE2L2, NOTCH1, NOTCH2, NSD1, PIK3CA, TGFBR2, TP53, ..
  37. Jia H, Song L, Cong Q, Wang J, Xu H, Chu Y, et al. The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network. Oncogene. 2017;36:2655-2666 pubmed publisher
    The LIM protein AJUBA is a scaffold protein participating in the regulation of cell adhesion, mitosis, DNA damage, cell differentiation, proliferation, migration and gene transcription...
  38. Das Thakur M, Feng Y, Jagannathan R, Seppa M, Skeath J, Longmore G. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol. 2010;20:657-62 pubmed publisher
    The mammalian Ajuba LIM proteins (Ajuba, LIMD1, and WTIP) are adaptor proteins that exhibit the potential to communicate cell adhesive events with nuclear responses to remodel epithelia...
  39. Ouyang H, Guo Z, Cheng Z, Guo Y. siRNA-mediated knockdown of JUB expression suppresses the proliferation of glioblastoma cells. Cancer Biomark. 2015;15:477-84 pubmed publisher
    ..this study, we aimed to investigate the functional relationship between glioma and a potential tumor related gene JUB. Lentivirus-based RNA interference was carried out to knock down JUB expression in human glioma cells U251...
  40. Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, et al. LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. Oncogene. 2015;34:73-83 pubmed publisher
    ..the NF2-Hippo pathway, and eventually found that MM cells frequently showed downregulation of LIM-domain protein AJUBA, a binding partner of large tumor suppressor type 2 (LATS2), which is one of the last-step kinases of the NF2-..
  41. Ferrand A, Chevrier V, Chauvin J, Birnbaum D. Ajuba: a new microtubule-associated protein that interacts with BUBR1 and Aurora B at kinetochores in metaphase. Biol Cell. 2009;101:221-35 pubmed publisher
    The role of the LIM-domain-containing protein Ajuba was initially described in cell adhesion and migration processes and recently in mitosis as an activator of the Aurora A kinase...
  42. Marie H, Billups D, Bedford F, Dumoulin A, Goyal R, Longmore G, et al. The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Mol Cell Neurosci. 2002;19:152-64 pubmed
    We have identified a cytoplasmic LIM protein, Ajuba, which interacts with the amino terminus of GLT-1, the most abundant plasma membrane glutamate transporter in the brain...
  43. Song P, Zhang Y, Ma G, Zhang Y, Zhou A, Xie J. Gastrointestinal Absorption and Metabolic Dynamics of Jujuboside A, A Saponin Derived from the Seed of Ziziphus jujuba. J Agric Food Chem. 2017;65:8331-8339 pubmed publisher
    ..Furthermore, the metabolites, jujuboside B (JuB) and jujubogenin, exhibited significant effects on the expression and activation of ?-amino-butyric acid A (GABA(A))..
  44. McCormack J, Bruche S, Ouadda A, Ishii H, Lu H, García Cattaneo A, et al. The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts. Sci Rep. 2017;7:9249 pubmed publisher
    Levels of active Rac1 at epithelial junctions are partially modulated via interaction with Ajuba, an actin binding and scaffolding protein...
  45. Zhang M, Singh R, Peng S, Mazumdar T, Sambandam V, Shen L, et al. Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors. Cancer Lett. 2017;392:71-82 pubmed publisher
    ..To fill this gap, we used 59 molecularly characterized HNSCC cell lines and found that mutations of AJUBA, SMAD4 and RAS predicted sensitivity and resistance to treatment with inhibitors of polo-like kinase 1 (PLK1), ..
  46. Liang X, Zhang G, Zeng Y, Yang H, Li W, Liu Q, et al. LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer. Cancer Sci. 2014;105:660-6 pubmed publisher
    ..b>Ajuba family proteins are LIM domain-containing proteins and are reported to be transcription repressors regulating ..
  47. Chen X, Stauffer S, Chen Y, Dong J. Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis. J Biol Chem. 2016;291:14761-72 pubmed publisher
    Recent studies identified the adaptor protein Ajuba as a positive regulator of Yes-associated protein (YAP) oncogenic activity through inhibiting large tumor suppressor (Lats1/2) core kinases of the Hippo pathway, a signaling pathway ..
  48. Hsu D, Wang H, Tai S, Chou C, Hsieh C, Chiu P, et al. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell. 2014;26:534-48 pubmed publisher
    ..Here, we present our results on the mechanism by which Snail induces target gene transactivation to remodel the tumor microenvironment. ..
  49. Jia L, Gui B, Zheng D, Decker K, Tinay I, Tan M, et al. Androgen receptor-regulated miRNA-193a-3p targets AJUBA to promote prostate cancer cell migration. Prostate. 2017;77:1000-1011 pubmed publisher
    ..and demonstrate overexpression of miR-193a-3p increases cell migration through downregulating its target AJUBA. AJUBA is a LIM domain protein and contributes to the formation and stability of cadherin-mediated cell-cell ..
  50. Feng Y, Longmore G. The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. Mol Cell Biol. 2005;25:4010-22 pubmed
    The Zyxin/Ajuba family of cytosolic LIM domain-containing proteins has the potential to shuttle from sites of cell adhesion into the nucleus and thus can be candidate transducers of environmental signals...
  51. Bai M, Ni J, Wu J, Wang B, Shen S, Yu L. A novel mechanism for activation of Aurora-A kinase by Ajuba. Gene. 2014;543:133-9 pubmed publisher
    ..In this study, we found that the PreLIM domain of Ajuba, another important activator of Aurora-A, induces the autophosphorylation of the C-terminal kinase domain of ..
  52. Bi L, Ma F, Tian R, Zhou Y, Lan W, Song Q, et al. AJUBA increases the cisplatin resistance through hippo pathway in cervical cancer. Gene. 2018;644:148-154 pubmed publisher
    Though LIM-domain protein AJUBA was identified as a putative oncogene, the function and underlying mechanisms of AJUBA in cervical cancer remain largely unknown...
  53. Du P, Huang P, Huang X, Li X, Feng Z, Li F, et al. Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance. Sci Rep. 2017;7:15324 pubmed publisher
    ..PTEN, DCDC1 and CUL3 were first reported as SMGs in ESCC. Notably, the AJUBA mutations and mutational signature4 were significantly correlated with a poorer survival in patients with ESCC...
  54. Foxler D, Bridge K, James V, Webb T, Mee M, Wong S, et al. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol. 2012;14:201-8 pubmed publisher
    ..LIMD1 family member proteins Ajuba and WTIP also bind to VHL and PHDs 1 and 3, indicating that these LIM domain-containing proteins represent a ..
  55. Nola S, Daigaku R, Smolarczyk K, Carstens M, Martin Martin B, LONGMORE G, et al. Ajuba is required for Rac activation and maintenance of E-cadherin adhesion. J Cell Biol. 2011;195:855-71 pubmed publisher
    ..b>Ajuba, a LIM domain protein, colocalizes with cadherins, yet Ajuba function at junctions is unknown...
  56. James V, Zhang Y, Foxler D, de Moor C, Kong Y, Webb T, et al. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2010;107:12499-504 pubmed publisher
    ..Herein we reveal the identification of a family of three LIM domain-containing proteins, LIMD1, Ajuba and WTIP (Ajuba LIM proteins) as novel mammalian processing body (P-body) components, which highlight a novel ..
  57. Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, Yamamoto T. LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. FEBS Lett. 2006;580:782-8 pubmed
    ..We performed yeast two-hybrid screening and identified a LIM protein Ajuba, as a binding partner of LATS2...
  58. Shi X, Chen Z, Hu X, Luo M, Sun Z, Li J, et al. AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression. Oncotarget. 2016;7:36407-36418 pubmed publisher
    The LIM-domain protein AJUBA has been reported to be involved in cell-cell adhesion, proliferation, migration and cell fate decision by acting as a scaffold or adaptor protein...
  59. Yang W, Han W, Qin A, Wang Z, Xu J, Qian Y. The emerging role of Hippo signaling pathway in regulating osteoclast formation. J Cell Physiol. 2017;: pubmed publisher
    ..including NF-?B, MAPKs, AP1 and NFATc1, Hippo-signaling molecules such as YAP/TAZ/TEAD complex, RASSF2, MST2 and Ajuba could also potentially modulate osteoclast differentiation and function...
  60. Fatemifar G, Hoggart C, Paternoster L, Kemp J, Prokopenko I, Horikoshi M, et al. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Hum Mol Genet. 2013;22:3807-17 pubmed publisher
    ..080 × 10(-17)). Three of these loci, containing the genes HMGA2, AJUBA and ADK, also showed evidence of association with craniofacial distances, particularly those indexing facial width...