Gene Symbol: AIMP1
Description: aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Alias: EMAP2, EMAPII, HLD3, SCYE1, p43, aminoacyl tRNA synthase complex-interacting multifunctional protein 1, ARS-interacting multifunctional protein 1, endothelial monocyte-activating polypeptide 2, endothelial-monocyte activating polypeptide II, multisynthase complex auxiliary component p43, multisynthetase complex auxiliary component p43, small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
Species: human
Products:     AIMP1

Top Publications

  1. Liu J, Schwarz M. Identification of protease-sensitive sites in Human Endothelial-Monocyte Activating Polypeptide II protein. Exp Cell Res. 2006;312:2231-7 pubmed
    ..Although several fragments are processed from pEMAP II within a 44 AA residue stretch, cathepsin L cleaves pEMAP II within 4 amino acids of the determined N-terminal sequence, suggesting that this region is sensitive to proteinases. ..
  2. Kao J, Houck K, Fan Y, Haehnel I, Libutti S, Kayton M, et al. Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. J Biol Chem. 1994;269:25106-19 pubmed
    ..These data suggest that recombinant EMAP II, a tumor-derived cytokine, has properties of a proinflammatory mediator with the capacity to prime the tumor vasculature for a locally destructive process. ..
  3. Quevillon S, Agou F, Robinson J, Mirande M. The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. J Biol Chem. 1997;272:32573-9 pubmed
    b>p43 is one of the three auxiliary components invariably associated with nine aminoacyl-tRNA synthetases as a multienzyme complex ubiquitous to all eukaryotic cells from flies to humans...
  4. Kao J, Ryan J, Brett G, Chen J, Shen H, Fan Y, et al. Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms. J Biol Chem. 1992;267:20239-47 pubmed
    ..Through its potential to activate host effector mechanisms, EMAP II could contribute to the biology of immunogenic tumors, such as the meth A fibrosarcoma. ..
  5. Quevillon S, Robinson J, Berthonneau E, Siatecka M, Mirande M. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. J Mol Biol. 1999;285:183-95 pubmed publisher
    ..In particular, p38 was found to associate with itself to form a dimer, but also with p43, with the class I tRNA synthetases ArgRS and GlnRS, with the class II synthetases AspRS and LysRS, and with the ..
  6. Park S, Jung K, Lee J, Jo Y, Motegi H, Kim S, et al. Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. J Biol Chem. 1999;274:16673-6 pubmed
    b>Endothelial monocyte activating polypeptide II (EMAPII) is a cytokine that is specifically induced by apoptosis...
  7. Shalak V, Kaminska M, Mitnacht Kraus R, Vandenabeele P, Clauss M, Mirande M. The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component. J Biol Chem. 2001;276:23769-76 pubmed
    Endothelial-monocyte-activating polypeptide II (EMAPII) is an inflammatory cytokine released under apoptotic conditions...
  8. Murray J, Heng Y, Symonds P, Rice K, Ward W, Huggins M, et al. Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis. J Leukoc Biol. 2004;75:772-6 pubmed
    ..EMAP-II is closely related or identical to the p43 auxiliary protein of the multisynthase complex, which is involved in protein synthesis...
  9. Clauss M, Voswinckel R, Rajashekhar G, Sigua N, Fehrenbach H, Rush N, et al. Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. J Clin Invest. 2011;121:2470-9 pubmed publisher
    ..we investigated the proapoptotic and monocyte chemoattractant cytokine endothelial monocyte-activating protein 2 (EMAPII)...

More Information

Publications156 found, 100 shown here

  1. Lee Y, Han J, Son S, Choi J, Jeon E, Bae S, et al. AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. Biochem Biophys Res Commun. 2008;371:395-400 pubmed publisher
    b>AIMP1 (also known as p43) is a factor associated with a macromolecular aminoacyl-tRNA synthetase (ARS) complex but also plays diverse regulatory roles in various physiological processes...
  2. Awasthi N, Schwarz M, Verma V, Cappiello C, Schwarz R. Endothelial monocyte activating polypeptide II interferes with VEGF-induced proangiogenic signaling. Lab Invest. 2009;89:38-46 pubmed publisher
    b>Endothelial monocyte activating polypeptide II (EMAP II) is a proinflammatory cytokine with antiangiogenic properties...
  3. Moujalled D, Cook W, Lluis J, Khan N, Ahmed A, Callus B, et al. In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-?B, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-?B is required to prevent it. Cell Death Differ. 2012;19:808-15 pubmed publisher
    ..Reconstitution of FLIP(-/-) MEFs with the FLIP isoforms FLIP-L, FLIP-R, or FLIP-p43 protected these cells from dying when treated with TNF or FasL, whether or not cIAPs were depleted...
  4. Liu L, Xie H, Xue Y, Liu Y, Li Z, Wang P. Endothelial-monocyte-activating polypeptide II induces rat C6 glioma cell apoptosis via the mitochondrial pathway. Biochem Biophys Res Commun. 2015;457:595-601 pubmed publisher
    ..All of these results strongly suggest that EMAP II could induce rat C6 glioma cells apoptosis via the mitochondrial pathway, and ROS, Bax/Bcl-2 might be involved in this processing. ..
  5. Ji S, Li W, Baloch A, Wang M, Cao B. Improved production of sublancin via introduction of three characteristic promoters into operon clusters responsible for this novel distinct glycopeptide biosynthesis. Microb Cell Fact. 2015;14:17 pubmed publisher
    ..subtilis 168 (trpC2)]. Meanwhile, other two strong promoters of P43 and PluxS were respectively placed before sunI and sunT-bdbA-sunS-bdbB, encoding five functional proteins that ..
  6. Cui W, Han L, Cheng J, Liu Z, Zhou L, Guo J, et al. Engineering an inducible gene expression system for Bacillus subtilis from a strong constitutive promoter and a theophylline-activated synthetic riboswitch. Microb Cell Fact. 2016;15:199 pubmed
    ..A novel genetic element composed of the promoter P43 and a theophylline-riboswitch was developed and characterized in B. subtilis...
  7. BoAli A, Tlili Graiess K, Alhashem A, Alshahwan S, Zuccoli G, Tabarki B. Novel Homozygous Mutation of the AIMP1 Gene: A Milder Neuroimaging Phenotype With Preservation of the Deep White Matter. Pediatr Neurol. 2019;91:57-61 pubmed publisher
    Mutations in AIMP1, which plays an important role in the development and maintenance of axon-cytoskeleton integrity and regulating neurofilaments, cause neurodegeneration of variable severity and white matter abnormalities...
  8. Gubin A, Njoroge J, Bouffard G, Miller J. Gene expression in proliferating human erythroid cells. Genomics. 1999;59:168-77 pubmed
    ..In addition to known transcripts, 44 novel EST were discovered. This transcriptional profile provides the first genomic-scale description of gene activity in erythroid progenitor cells. ..
  9. Huang K, Zhang T, Jiang B, Yan X, Mu W, Miao M. Overproduction of Rummeliibacillus pycnus arginase with multi-copy insertion of the arg R.pyc cassette into the Bacillus subtilis chromosome. Appl Microbiol Biotechnol. 2017;101:6039-6048 pubmed publisher
    ..pyc cassettes, in which the R. pycnus arginase gene was fused with the strong promoter P43, were inserted into the recipient chromosome...
  10. On Wah D, Kavaliers M, Bishnoi I, Ossenkopp K. Lipopolysaccharide (LPS) induced sickness in early adolescence alters the behavioral effects of the short-chain fatty acid, propionic acid, in late adolescence and adulthood: Examining anxiety and startle reactivity. Behav Brain Res. 2019;360:312-322 pubmed publisher
    ..They were later administered either PPA (500 mg/kg i.p.) or the vehicle during late adolescence on P40 and P43, and were subsequently tested on the light-dark anxiety test and acoustic startle response, respectively...
  11. Sand K, Landsverk O, Berg Larsen A, Bakke O, Gregers T. The human-specific invariant chain isoform Iip35 modulates Iip33 trafficking and function. Immunol Cell Biol. 2014;92:791-8 pubmed publisher
    ..expressed, the four isoforms form mixed heterotrimers in the ER; however, mainly due to the absence of the Iip35/p43 isoforms in mice, little is known about how they influence general Ii function...
  12. Li Z, Liu X, Liu Y, Xue Y, Wang P, Liu L. Role of cAMP-dependent protein kinase A activity in low-dose endothelial monocyte-activating polypeptide-II-induced opening of blood-tumor barrier. J Mol Neurosci. 2015;56:60-9 pubmed publisher
    ..In summary, our present study demonstrates that the cAMP/PKA signaling cascade works as a crucial signaling pathway in EMAP-II-induced BTB hyperpermeability. ..
  13. Wilkinson L, Handel C, Van Hemert C, Loiseau C, Sehgal R. Avian malaria in a boreal resident species: long-term temporal variability, and increased prevalence in birds with avian keratin disorder. Int J Parasitol. 2016;46:281-90 pubmed publisher
    ..Sequence analysis of the parasite cytochrome b gene revealed a single Plasmodium spp. lineage, P43. Our results demonstrate associations between prevalence of avian malaria and a variety of biological and ..
  14. Ji M, Wang Z, Sun X, Tang H, Zhang H, Jia M, et al. Repeated Neonatal Sevoflurane Exposure-Induced Developmental Delays of Parvalbumin Interneurons and Cognitive Impairments Are Reversed by Environmental Enrichment. Mol Neurobiol. 2017;54:3759-3770 pubmed publisher
    ..Exposure of neonatal mice to sevoflurane resulted in a reduced freezing response in the contextual test at P43 but not P90. The PV expression in these mice was decreased at P9, P14, P28, and P42, but not at ?P60...
  15. Cianci M, Groves M, Barford D, Schneider T. Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23(Nterm). Acta Crystallogr D Struct Biol. 2016;72:403-12 pubmed publisher
    ..1 Å resolution, with unit-cell parameters a = b = 61.2, c = 151.5 Å, and belonged to space group P43. The refined structure to 3.1 Å resolution has an R factor of 18.7% and an Rfree of 25.9%...
  16. Escalante C, Yang D. Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix. J Biol Chem. 1993;268:6014-23 pubmed
    ..The structure and function of the N-terminal peptide in aspartyl-tRNA synthetase and in the synthetase complex will be discussed. ..
  17. Wei X, Zhou Y, Chen J, Cai D, Wang D, Qi G, et al. Efficient expression of nattokinase in Bacillus licheniformis: host strain construction and signal peptide optimization. J Ind Microbiol Biotechnol. 2015;42:287-95 pubmed publisher
    ..Second, the gene fragments of P43 promoter, Svpr, nattokinase and TamyL were combined into pHY300PLK to form the expression vector pP43SNT...
  18. Song W, Nie Y, Mu X, Xu Y. Enhancement of extracellular expression of Bacillus naganoensis pullulanase from recombinant Bacillus subtilis: Effects of promoter and host. Protein Expr Purif. 2016;124:23-31 pubmed publisher
    ..further enhance the yield of PUL, the promoter PHpaII in pMA0911 was replaced by a stronger constitutive promoter P43. Then the activity was increased to 8.7 U ml(-1) from the recombinant B. subtilis WB800/pMA0911-P43-pul...
  19. Liu X, Yang H, Zheng J, Ye Y, Pan L. Identification of strong promoters based on the transcriptome of Bacillus licheniformis. Biotechnol Lett. 2017;39:873-881 pubmed publisher
    ..promoter pBL9 exhibited the strongest activity which was comparable to that of the widely used strong promoter p43. Furthermore, the pro-transglutaminase from Streptomyces mobaraensis (pro-MTG) was expressed under the control of ..
  20. Pessemesse L, Lepourry L, Bouton K, Levin J, Cabello G, Wrutniak Cabello C, et al. p28, a truncated form of TRα1 regulates mitochondrial physiology. FEBS Lett. 2014;588:4037-43 pubmed publisher
    ..identified in mitochondria two truncated forms of the T3 nuclear receptor TRα1, with molecular weights of 43kDa (p43) and 28kDa (p28) respectively located in the matrix and in the inner membrane...
  21. Rezvani M, Mendoza M, Koci M, Daron C, Levy J, Hassan H. Draft Genome Sequences of Lactobacillus animalis Strain P38 and Lactobacillus reuteri Strain P43 Isolated from Chicken Cecum. Genome Announc. 2016;4: pubmed publisher
    Here, we present the genome sequence of Lactobacillus animalis strain P38 and Lactobacillus reuteri strain P43, both isolated from the cecum content of a 4-week old chicken fed a diet supplemented with the prebiotic ?(1-4)galacto-..
  22. Yuan C, Yan L, Solanki P, Vatner S, Vatner D, Schwarz M. Blockade of EMAP II protects cardiac function after chronic myocardial infarction by inducing angiogenesis. J Mol Cell Cardiol. 2015;79:224-31 pubmed publisher
  23. Yamada H, Nagae T, Watanabe N. High-pressure protein crystallography of hen egg-white lysozyme. Acta Crystallogr D Biol Crystallogr. 2015;71:742-53 pubmed publisher the pressure increases to 950 MPa, the tetragonal crystal of HEWL undergoes a phase transition from P43212 to P43. Under high pressure, the crystal structure of the enzyme undergoes several local and global changes accompanied by ..
  24. Wang P, Wang P, Tian J, Yu X, Chang M, Chu X, et al. A new strategy to express the extracellular α-amylase from Pyrococcus furiosus in Bacillus amyloliquefaciens. Sci Rep. 2016;6:22229 pubmed publisher
    ..This design was assessed to be successful by comparing the various genes (mpfa and opfa), promoters (PamyA and P43), and strains (F30, F31, F32 and F30-∆amyA)...
  25. Li K, Cai D, Wang Z, He Z, Chen S. Development of an Efficient Genome Editing Tool in Bacillus licheniformis Using CRISPR-Cas9 Nickase. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..licheniformis DW2 with overexpression driven by the P43 promoter. The yvmC gene was deleted using the CRISPR-Cas9n technique with homology arms of 1...
  26. Blanchet E, Bertrand C, Annicotte J, Schlernitzauer A, Pessemesse L, Levin J, et al. Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis. FASEB J. 2012;26:40-50 pubmed publisher
    ..We have previously identified a mitochondrial triiodothyronine receptor (p43) that acts as a mitochondrial transcription factor of the organelle genome, which leads, in vitro and in vivo, to a ..
  27. Liao Y, Huang L, Wang B, Zhou F, Pan L. The global transcriptional landscape of Bacillus amyloliquefaciens XH7 and high-throughput screening of strong promoters based on RNA-seq data. Gene. 2015;571:252-62 pubmed publisher
    ..fused to eight candidate promoters from 288 genes with higher expression levels (RPKM values) than the control gene P43-bgaB...
  28. Alexovič Matiašová A, Sevc J, Tomori Z, Gombalová Z, Gedrová S, Daxnerova Z. Quantitative analyses of cellularity and proliferative activity reveals the dynamics of the central canal lining during postnatal development of the rat. J Comp Neurol. 2017;525:693-707 pubmed publisher
    ..In the rat, the length of the cell cycle increases from 100.3?±?35.7 hours at P1 to 401.4?±?80.6 hours at P43, with a sudden extension between P15 and P22...
  29. Wah D, Ossenkopp K, Bishnoi I, Kavaliers M. Predator odor exposure in early adolescence influences the effects of the bacterial product, propionic acid, on anxiety, sensorimotor gating, and acoustic startle response in male rats in later adolescence and adulthood. Physiol Behav. 2018;199:35-46 pubmed publisher
    ..They were administered either PPA (500 mg/kg i.p.), or its vehicle in late adolescence on P40 and P43, and were subsequently tested on the light-dark anxiety task and acoustic startle task, respectively...
  30. Kim S, Son W, Park M, Kim C, Cha B, Yoon K, et al. ARS-interacting multi-functional protein 1 induces proliferation of human bone marrow-derived mesenchymal stem cells by accumulation of β-catenin via fibroblast growth factor receptor 2-mediated activation of Akt. Stem Cells Dev. 2013;22:2630-40 pubmed publisher
    ARS-Interacting Multi-functional Protein 1 (AIMP1) is a cytokine that is involved in the regulation of angiogenesis, immune activation, and fibroblast proliferation...
  31. Ahn S, Jeong E, Lee T, Kim S, Kim H, Kim C. Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells. Cell Oncol (Dordr). 2014;37:377-86 pubmed publisher
    ..Moreover, we found that cytoplasmic p27 bound to a cleaved intermediate (p43/p41) of caspase 8 and that inhibition of cytoplasmic translocation of p27 reduced gefitinib-induced cell death in ..
  32. Hong S, Cho J, Yoon K, Lim D, Kim C, Lee S, et al. The antibody atliximab attenuates collagen-induced arthritis by neutralizing AIMP1, an inflammatory cytokine that enhances osteoclastogenesis. Biomaterials. 2015;44:45-54 pubmed publisher
    ARS-interacting multifunctional protein 1 (AIMP1) induces production of inflammatory cytokines from immune cells...
  33. Chen L, Xue Y, Zheng J, Liu X, Liu J, Chen J, et al. MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II (EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the Expressions of ZO-1, Occludin and Claudin-5. Front Mol Neurosci. 2018;11:35 pubmed publisher
    ..As a result, the BTB permeability increased. ..
  34. Wrutniak Cabello C, Casas F, Cabello G. Thyroid Hormone Action: The p43 Mitochondrial Pathway. Methods Mol Biol. 2018;1801:163-181 pubmed publisher
    ..Import and in organello transcription experiments performed in isolated mitochondria led to the conclusion that p43 is a transcription factor of the mitochondrial genome, inducing changes in the mitochondrial/nuclear crosstalk...
  35. Zhou C, Xue Y, Ma Y. Characterization and high-efficiency secreted expression in Bacillus subtilis of a thermo-alkaline β-mannanase from an alkaliphilic Bacillus clausii strain S10. Microb Cell Fact. 2018;17:124 pubmed publisher
    ..5% was obtained using SPlipA and P43 after 72 h cultivation in 2 × SR medium...
  36. Wang S, Jiang M, Lin S, Chen M, Wang H, Duh C. Calpains mediate the proteolytic modification of human cytomegalovirus UL112-113 proteins. J Gen Virol. 2015;96:1115-26 pubmed publisher
    ..The human cytomegalovirus (HCMV) UL112-113 gene is implicated in lytic viral replication. The UL112-113 proteins p34, p43, p50 and p84 are expressed via alternative splicing...
  37. Lei H, Zhou X, Ruan Z, Sun W, Eriani G, Wang E. Calpain Cleaves Most Components in the Multiple Aminoacyl-tRNA Synthetase Complex and Affects Their Functions. J Biol Chem. 2015;290:26314-27 pubmed publisher
    ..The cleavage sites of calpain in ArgRS, GlnRS, and p43 were precisely mapped. After cleavage, their N-terminal regions were removed...
  38. Li Z, Liu X, Liu Y, Xue Y, Liu J, Teng H, et al. Low-Dose Endothelial Monocyte-Activating Polypeptide-II Induces Blood-Tumor Barrier Opening Via the cAMP/PKA/Rac1 Pathway. J Mol Neurosci. 2016;58:153-61 pubmed publisher
    ..In conclusion, this study demonstrates that low-dose EMAP-II induces BTB hyperpermeability via the cAMP/PKA/Rac1 signaling pathway. ..
  39. Liu X, Wang H, Wang B, Pan L. High-level extracellular protein expression in Bacillus subtilis by optimizing strong promoters based on the transcriptome of Bacillus subtilis and Bacillus megaterium. Protein Expr Purif. 2018;151:72-77 pubmed publisher
    ..the beta-galactosidase (bgaB) gene as a reporter were stronger than those of the well-characterized strong promoter P43. The expression level of recombinant Pro-transglutaminase (pro-MTG) from Streptomyces mobaraensis achieved 87...
  40. Lu H, Chelvanambi S, Poirier C, Saliba J, March K, Clauss M, et al. EMAPII Monoclonal Antibody Ameliorates Influenza A Virus-Induced Lung Injury. Mol Ther. 2018;26:2060-2069 pubmed publisher
    ..Here, we analyzed the role of EMAPII, a stress- and virus-induced pro-inflammatory and pro-apoptotic factor, in IAV-induced lung injury...
  41. Ardisson Araújo D, de Melo F, Andrade M, Sihler W, Báo S, Ribeiro B, et al. Genome sequence of Erinnyis ello granulovirus (ErelGV), a natural cassava hornworm pesticide and the first sequenced sphingid-infecting betabaculovirus. BMC Genomics. 2014;15:856 pubmed publisher
    ..The presence of he65 and p43 homologous genes suggests horizontal gene transfer from Alphabaculovirus...
  42. Kim M, Song J, Cohen E, Cho D, Kim T. Aminoacyl tRNA Synthetase--Interacting Multifunctional Protein 1 Activates NK Cells via Macrophages In Vitro and In Vivo. J Immunol. 2017;198:4140-4147 pubmed publisher
    Aminoacyl tRNA synthetase-interacting multifunctional protein 1 (AIMP1) has been reported to have antitumor effects in various tumor models. However, mechanisms by which AIMP1 ameliorates tumorigenesis are not well understood...
  43. Alkasalias T, Flaberg E, Kashuba V, Alexeyenko A, Pavlova T, Savchenko A, et al. Inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent. Proc Natl Acad Sci U S A. 2014;111:17188-93 pubmed publisher
  44. Yao Z, Zhang P, Guo H, Shi J, Liu S, Liu Y, et al. RIP1 modulates death receptor mediated apoptosis and autophagy in macrophages. Mol Oncol. 2015;9:806-17 pubmed publisher
    ..Furthermore, expression and bioactivity of the p43/41-caspase-8 variant are critical to TRAIL-induced autophagy and apoptosis...
  45. Kaminska M, Havrylenko S, Decottignies P, Gillet S, Le Marechal P, Negrutskii B, et al. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. J Biol Chem. 2009;284:6053-60 pubmed publisher
    ..the rules of assembly of this particle, expression of the three nonsynthetase components of MARS, p18, p38, and p43, was blocked by stable small interfering RNA silencing...
  46. Schikorski D, Cuvillier Hot V, Boidin Wichlacz C, Slomianny C, Salzet M, Tasiemski A. Deciphering the immune function and regulation by a TLR of the cytokine EMAPII in the lesioned central nervous system using a leech model. J Immunol. 2009;183:7119-28 pubmed publisher
    A highly conserved ortholog of the human complex p43/endothelial monocyte-activating polypeptide II (EMAPII) was characterized in the CNS of the leech Hirudo medicinalis...
  47. Zhu F, Clauss M. Evaluating membrane affinity by integrating protein orientations. J Mol Graph Model. 2014;54:141-7 pubmed publisher
    ..Here we seek to evaluate the membrane interactions for EMAPII, a protein found to be released from the cell by unknown mechanisms, as well as several other proteins...
  48. Li Z, Liu Y, Liu X, Xue Y, Wang P, Liu L. Low-dose endothelial monocyte-activating polypeptide-II increases permeability of blood-tumor barrier via a PKC-ζ/PP2A-dependent signaling mechanism. Exp Cell Res. 2015;331:257-66 pubmed publisher
  49. Zhou J, Wang W, Xie Y, Zhao Y, Chen X, Xu W, et al. Proteomics-Based Identification and Analysis of Proteins Associated with Helicobacter pylori in Gastric Cancer. PLoS ONE. 2016;11:e0146521 pubmed publisher
    ..19 homolog (PRPF19), ATP synthase, calmodulin (CaM), p64 CLCP, Ran-specific GTPase-activating protein (RanGAP), P43 and calreticulin...
  50. Bertrand Gaday C, Pessemesse L, Cabello G, Wrutniak Cabello C, Casas F. Temperature homeostasis in mice lacking the p43 mitochondrial T3 receptor. FEBS Lett. 2016;590:982-91 pubmed publisher
    ..the function of the mitochondrial TRα receptor in these phenomena, we used mice lacking specifically the p43 mitochondrial T3 receptor...
  51. Fitzpatrick A, Stephenson S, Brown M, Nguyen K, Douglas S, Brown L. Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features. J Allergy Clin Immunol Pract. 2017;5:410-419.e4 pubmed publisher
    ..expression of inflammatory cytokines and chemokines related to IL-2, IL-10, and TNF signaling pathways, namely, AIMP1, CCR2, IL10RB, and IL5, strongly differentiated children who failed to achieve control with triamcinolone ..
  52. Zhang J, Kang Z, Ling Z, Cao W, Liu L, Wang M, et al. High-level extracellular production of alkaline polygalacturonate lyase in Bacillus subtilis with optimized regulatory elements. Bioresour Technol. 2013;146:543-548 pubmed publisher
    ..7 U mL(-1). By optimizing and applying strong promoter P43 and Shine-Dalgarno sequence, higher titer of 446.3 U mL(-1) PGL was achieved...
  53. Liu Y, He P, Liu F, Cheng X, Zhang M. [Influence of I2PP2A gene silencing by RNA interference on proliferation and apoptosis of human acute promyelocytic leukemia cell line NB4-R1]. Zhonghua Xue Ye Xue Za Zhi. 2014;35:732-6 pubmed publisher
    ..0 ± 3.1)% and (57.0 ± 4.0)%, respectively; Meanwhile, the cleaved caspase-8 (p43) and cleaved PARP (p89) increased by (36.0 ± 2.5)% and (45.0 ± 4...
  54. Li Z, Liu X, Liu Y, Xue Y, Wang P, Liu L, et al. Roles of Serine/Threonine Phosphatases in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood-Tumor Barrier. J Mol Neurosci. 2015;57:11-20 pubmed publisher
  55. Husch A, Dietz S, Hong D, Harris Warrick R. Adult spinal V2a interneurons show increased excitability and serotonin-dependent bistability. J Neurophysiol. 2015;113:1124-34 pubmed publisher
    ..and serotonergic modulation of the V2a class of excitatory spinal interneurons in behaviorally mature (older than P43) mice to those in neonatal mice...
  56. Wrutniak Cabello C, Casas F, Cabello G. Mitochondrial T3 receptor and targets. Mol Cell Endocrinol. 2017;458:112-120 pubmed publisher
    ..If p28 activity remains unknown, p43 binds to T3 responsive elements occurring in the organelle genome, and, in the T3 presence, stimulates ..
  57. Kim M, Kim T. Aminoacyl tRNA Synthetase-Interacting Multifunctional Protein 1 Acts as a Novel B Cell-Activating Factor In Vitro and In Vivo. J Immunol. 2015;194:4729-36 pubmed publisher
    ..We previously reported that aminoacyl tRNA synthetase-interacting multifunctional protein 1 (AIMP1) functions as a novel proinflammatory cytokine that activates macrophages and dendritic cells...
  58. Liu H, Roos S, Jonsson H, Ahl D, Dicksved J, Lindberg J, et al. Effects of Lactobacillus johnsonii and Lactobacillus reuteri on gut barrier function and heat shock proteins in intestinal porcine epithelial cells. Physiol Rep. 2015;3: pubmed publisher
    ..GG (LGG), and two novel porcine isolates, Lactobacillus johnsonii strain P47-HY and Lactobacillus reuteri strain P43-HUV, on cytoprotective HSP expression and gut barrier function, were investigated in a porcine IPEC-J2 intestinal ..
  59. Schwarz M, Lee D, Bartlett S. Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 simultaneously binds Glutamyl-Prolyl-tRNA synthetase and scaffold protein aminoacyl tRNA synthetase complex interacting multifunctional protein 3 of the multi-tRNA synthetase com. Int J Biochem Cell Biol. 2018;99:197-202 pubmed publisher
    ..ARS) and three scaffold proteins: aminoacyl tRNA synthetase complex interacting multifunctional proteins (AIMP1, 2 and 3)...
  60. Feng Y, Liu S, Jiao Y, Gao H, Wang M, Du G, et al. Enhanced extracellular production of L-asparaginase from Bacillus subtilis 168 by B. subtilis WB600 through a combined strategy. Appl Microbiol Biotechnol. 2017;101:1509-1520 pubmed publisher
    ..91 U/mL). Second, Hpa II promoter was replaced by a strong promoter, P43 promoter, resulting in 38.1 % enhanced ASN activity...
  61. Gao L, Han J, Liu H, Qu X, Lu Z, Bie X. Plipastatin and surfactin coproduction by Bacillus subtilis pB2-L and their effects on microorganisms. Antonie Van Leeuwenhoek. 2017;110:1007-1018 pubmed publisher
    ..pB2 into a plipastatin and surfactin coproducer, a gene expression cassette composed of a constitutive promoter (P43), functional gene sfp, and pleiotropic regulatory gene degQ was integrated into the chromosomal amyE locus of ..
  62. Bonnefond L, Castro de Moura M, Ribas De Pouplana L, Nureki O. Crystal structures of Entamoeba histolytica lysyl-tRNA synthetase reveal conformational changes upon lysine binding and a specific helix bundle domain. FEBS Lett. 2014;588:4478-86 pubmed
    ..The Entamoeba EMAPII-like polypeptide is not resolved in the crystals, but another Entamoeba-specific insertion could be modeled as a ..
  63. Park S, Ahn H, Kim J, Lee C. Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography. PLoS ONE. 2015;10:e0142253 pubmed publisher
    Eight aminoacyl-tRNA synthetases (M, K, Q, D, R, I, EP and LARS) and three auxiliary proteins (AIMP1, 2 and 3) are known to form a multi-tRNA synthetase complex (MSC) in mammalian cells...
  64. Musante L, Püttmann L, Kahrizi K, Garshasbi M, Hu H, Stehr H, et al. Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. Hum Mutat. 2017;38:621-636 pubmed publisher
    ..The latter affects the mitochondrial localization signal of WARS2, causing protein mislocalization. Including AIMP1, which we have recently implicated in the etiology of ID, three genes with a role in tRNA-aminoacylation are now ..
  65. Park S, Park H, Jeong I, Cho Y, Lee H, Kang Y, et al. Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus. Biomarkers. 2010;15:358-66 pubmed publisher
    ..Anti-aaRS autoantibodies were identified in 37.9% of patients with type 1 DM. The results of this study demonstrate for the first time that autoantibodies against aaRSs are specifically associated with type 1 DM. ..
  66. Ma Y, Chiao Y, Clark R, Flynn E, Yabluchanskiy A, Ghasemi O, et al. Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence. Cardiovasc Res. 2015;106:421-31 pubmed publisher Bcl6, Il1r1, Ccl24, Crp, and Cxcl13 patterns, whereas LV wall thickness was most predicted by Abcf1, Tollip, Scye1, and Mif patterns...
  67. Ma J, Meng F, Li S, Liu L, Zhao L, Liu Y, et al. Autophagy Induction by Endothelial-Monocyte Activating Polypeptide II Contributes to the Inhibition of Malignant Biological Behaviors by the Combination of EMAP II with Rapamycin in Human Glioblastoma. Front Mol Neurosci. 2015;8:74 pubmed publisher
    ..The combination of EMAP II with rapamycin demonstrated the inhibitory effect on the malignant biological behaviors of human GBM cells and GSCs in vitro and in vivo. ..
  68. Zhou W, Liu L, Xue Y, Zheng J, Liu X, Ma J, et al. Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway. Front Mol Neurosci. 2017;10:68 pubmed publisher
  69. Shiba K, Suzuki N, Shigesada K, Namba Y, Schimmel P, Noda T. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. Proc Natl Acad Sci U S A. 1994;91:7435-9 pubmed
    ..This result may have implications for the historical development of an operational RNA code for amino acids. ..
  70. Ahn S, Hong S, Park Y, Jung S, Song J, Park Y, et al. Serum aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1), a novel disease activity predictive biomarker of systemic lupus erythematosus. Clin Exp Rheumatol. 2018;36:533-539 pubmed
    Secreted aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) has been reported to have pro-inflammatory properties...
  71. Kao J, Fan Y, Haehnel I, Brett J, Greenberg S, Clauss M, et al. A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory resp. J Biol Chem. 1994;269:9774-82 pubmed
    ..These data indicate that the N-terminal region of EMAP II defines a biologically active locus of the molecule which interacts with target cells via a potentially novel cellular receptor. ..
  72. Adly A, Ismail E, Tawfik L, Ebeid F, Hassan A. Endothelial monocyte activating polypeptide II in children and adolescents with type 1 diabetes mellitus: Relation to micro-vascular complications. Cytokine. 2015;76:156-162 pubmed publisher
    ..EMAP II levels are related to inflammation, glycemic control, albuminuria level of patients and the risk of micro-vascular complications. ..
  73. Cheng W, Ren X, Zhang C, Cai J, Liu Y, Han S, et al. Bioinformatic profiling identifies an immune-related risk signature for glioblastoma. Neurology. 2016;86:2226-34 pubmed publisher
    ..We profiled the immune-related gene set and identified 8 genes (FOXO3, IL6, IL10, ZBTB16, CCL18, AIMP1, FCGR2B, and MMP9) with the greatest prognostic value in GBM...
  74. Chen J, Liu L, Liu Y, Liu X, Qu C, Meng F, et al. Low-Dose Endothelial-Monocyte-Activating Polypeptide-II Induced Autophagy by Down-Regulating miR-20a in U-87 and U-251 Glioma Cells. Front Cell Neurosci. 2016;10:128 pubmed publisher
    ..The combined treatment of EMAP-II with a miR-20a inhibitor showed a synergistic effect against glioma. ..
  75. Zhan Y, Zhu C, Sheng B, Cai D, Wang Q, Wen Z, et al. Improvement of glycerol catabolism in Bacillus licheniformis for production of poly-?-glutamic acid. Appl Microbiol Biotechnol. 2017;101:7155-7164 pubmed publisher
    ..of glycerol utilization was attempted by substituting the native glpFK promoter with the constitutive promoter (P43), ytzE promoter (PytzE), and bacABC operon promoter (PbacA), respectively...
  76. Casas F, Fouret G, Lecomte J, Cortade F, Pessemesse L, Blanchet E, et al. Skeletal muscle expression of p43, a truncated thyroid hormone receptor α, affects lipid composition and metabolism. J Bioenerg Biomembr. 2018;50:71-79 pubmed publisher
    ..The aim of this study was to explore the possible involvement of p43, a 43 Kda truncated form of the nuclear thyroid hormone receptor TRα1 which stimulates mitochondrial activity...
  77. Sen E, Ulger F, Kaya A, Akar N, Gonullu U. Serum endothelial monocyte-activating polypeptide-II: a novel biomarker in patients with non-small-cell lung cancer. Clin Lung Cancer. 2008;9:166-70 pubmed publisher
    ..Our results showed that serum EMAP-II levels are significantly higher in patients with NSCLC than in healthy subjects and suggest it is of potential prognostic value. ..
  78. Nguyen S, Kwasny S, Ding X, Williams J, Peet N, Bowlin T, et al. Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds. Bioorg Med Chem. 2015;23:5789-98 pubmed publisher
    ..g., P9, P14 and P43) exhibited favorable CC50 values against HeLa cells and maintained considerable antifungal activity.
  79. Li Z, Liu X, Liu Y, Xue Y, Liu J, Teng H, et al. Low-Dose Endothelial Monocyte-Activating Polypeptide-II Increases Blood-Tumor Barrier Permeability by Activating the RhoA/ROCK/PI3K Signaling Pathway. J Mol Neurosci. 2016;59:193-202 pubmed publisher
    ..In summary, this study demonstrates that low-dose EMAP-II can increase BTB permeability by activating the RhoA/ROCK/PI3K signaling pathway. ..
  80. Edwards M, Weiland J, Todd J, Stewart L, Lu S. ORF43 of maize rayado fino virus is dispensable for systemic infection of maize and transmission by leafhoppers. Virus Genes. 2016;52:303-7 pubmed publisher
    Maize rayado fino virus (MRFV) possesses an open reading frame (ORF43) predicted to encode a 43 kDa protein (p43) that has been postulated to be a viral movement protein...
  81. Liggins E, Serle W. Color Vision in Color Display Night Vision Goggles. Aerosp Med Hum Perform. 2017;88:448-456 pubmed publisher previous data suggesting that discrimination is best for colors close to the adapting point in color space (P43 phosphor in this case)...
  82. Techo S, Visessanguan W, Vilaichone R, Tanasupawat S. Characterization and Antibacterial Activity Against Helicobacter pylori of Lactic Acid Bacteria Isolated from Thai Fermented Rice Noodle. Probiotics Antimicrob Proteins. 2019;11:92-102 pubmed publisher
    ..Lb. fermentum P43-01 resisted to bile acids showed the broad spectrum of antimicrobial activity against H...
  83. van Horssen R, Rens J, Schipper D, Eggermont A, ten Hagen T. EMAP-II facilitates TNF-R1 apoptotic signalling in endothelial cells and induces TRADD mobilization. Apoptosis. 2006;11:2137-45 pubmed
  84. Tandle A, Calvani M, Uranchimeg B, Zahavi D, Melillo G, Libutti S. Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. Exp Cell Res. 2009;315:1850-9 pubmed publisher
    ..Our results suggest that one of the major anti-angiogenic functions of EMAP-II is exerted through its inhibition of the HIF-1alpha activities. ..
  85. Cho H, Maeng S, Cho H, Choi Y, Chung J, Lee S, et al. Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains. J Biol Chem. 2015;290:29313-28 pubmed publisher
    ..synthetase complex (MSC), consisting of nine different aminoacyl-tRNA synthetases and three non-enzymatic factors (AIMP1-3), serves as a hub for many signaling pathways in addition to its role in protein synthesis...
  86. Tian T, Li L, Zhang S, Ni H. Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions. Biol Trace Elem Res. 2016;174:369-376 pubmed
    ..parameters of brain damage (plane righting reflex, cliff avoidance reflex, and open field test) were observed at P43. At P63, we examined seizure threshold using penicillin, then the cerebral cortex were evaluated for real-time RT-..
  87. Cai D, Wei X, Qiu Y, Chen Y, Chen J, Wen Z, et al. High-level expression of nattokinase in Bacillus licheniformis by manipulating signal peptide and signal peptidase. J Appl Microbiol. 2016;121:704-12 pubmed publisher
    ..licheniformis. The P43 promoter, amyL terminator and AprN target gene were used to form the nattokinase expression vector, pHY-SP-NK, ..
  88. Schommartz T, Tang J, Brost R, Brune W. Differential Requirement of Human Cytomegalovirus UL112-113 Protein Isoforms for Viral Replication. J Virol. 2017;91: pubmed publisher
    ..It codes for four phosphoproteins, p34, p43, p50, and p84, all of which are expressed with early kinetics and accumulate at sites of viral DNA replication ..
  89. Kim Y, Shin J, Li R, Cheong C, Kim K, Kim S. A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases. J Biol Chem. 2000;275:27062-8 pubmed
    ..The peptide sequence that is responsible for cytokine activity is located, for the most part, in the beta1 strand. It is divided into two regions by a neighboring loop. ..
  90. Shalak V, Guigou L, Kaminska M, Wautier M, Wautier J, Mirande M. Characterization of p43(ARF), a derivative of the p43 component of multiaminoacyl-tRNA synthetase complex released during apoptosis. J Biol Chem. 2007;282:10935-43 pubmed
    ..This protein is also the precursor of the endothelial monocyte-activating polypeptide II (p43(EMAPII), corresponding to the C-terminal moiety of p43), a cytokine generated during apoptosis...
  91. Casas F, Pessemesse L, Grandemange S, Seyer P, Baris O, Gueguen N, et al. Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging. PLoS ONE. 2009;4:e5631 pubmed publisher
    In previous studies, we characterized a new hormonal pathway involving a mitochondrial T3 receptor (p43) acting as a mitochondrial transcription factor...
  92. Ni H, Zhao D, Tian T. Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures. Epilepsy Res. 2016;120:13-8 pubmed publisher
    ..Morris water maze test was performed during P37-P43. Then mossy fiber sprouting and the protein levels were detected by Timm staining and Western blot analysis, ..