AIM2

Summary

Gene Symbol: AIM2
Description: absent in melanoma 2
Alias: PYHIN4, interferon-inducible protein AIM2
Species: human
Products:     AIM2

Top Publications

  1. Cresswell K, Clarke C, Jackson J, Darcy P, Trapani J, Johnstone R. Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. Biochem Biophys Res Commun. 2005;326:417-24 pubmed
    The human HIN-200 family member AIM2 was originally identified in a screen for suppressors of melanoma tumorigenicity following introduction of chromosome 6 into the UACC903 human melanoma cell line...
  2. Hornung V, Ablasser A, Charrel Dennis M, Bauernfeind F, Horvath G, Caffrey D, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009;458:514-8 pubmed publisher
    ..cells, here we identify the PYHIN (pyrin and HIN domain-containing protein) family member absent in melanoma 2 (AIM2) as a receptor for cytosolic DNA, which regulates caspase-1...
  3. Kondo Y, Nagai K, Nakahata S, Saito Y, Ichikawa T, Suekane A, et al. Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation. Cancer Sci. 2012;103:782-90 pubmed publisher
    ..These analyses indicated that the absent in melanoma 2 (AIM2) gene and the interferon-inducible gene 16 (IFI16) mapped to the hematopoietic interferon-inducible nuclear ..
  4. DeYoung K, Ray M, Su Y, Anzick S, Johnstone R, Trapani J, et al. Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. Oncogene. 1997;15:453-7 pubmed
    ..We now report the molecular characterization of a novel gene termed AIM2 for (Absent In Melanoma), which represents a 1485 bp cDNA...
  5. Woerner S, Kloor M, Schwitalle Y, Youmans H, Doeberitz M, Gebert J, et al. The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. Genes Chromosomes Cancer. 2007;46:1080-9 pubmed
    ..Here, we examined in detail alterations of the absent in melanoma 2 (AIM2) gene that shows a high frequency of cMS frameshift mutations in MSI-H colorectal, gastric, and endometrial tumors...
  6. Patsos G, Germann A, Gebert J, Dihlmann S. Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. Int J Cancer. 2010;126:1838-1849 pubmed publisher
    Absent in melanoma 2 (AIM2) is a member of the interferon-inducible HIN-200 protein family. Recent findings point to a role of AIM2 function in both inflammation and cancer...
  7. Lee J, Li L, Gretz N, Gebert J, Dihlmann S. Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers. Oncogene. 2012;31:1242-53 pubmed publisher
    Absent in Melanoma 2 (AIM2) is a member of the HIN-200 family of hematopoietic, IFN-inducible, nuclear proteins, associated with both, infection defense and tumor pathology...
  8. Jin T, Perry A, Smith P, Jiang J, Xiao T. Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly. J Biol Chem. 2013;288:13225-35 pubmed publisher
    b>AIM2 binds dsDNA and associates with ASC through their PYDs to form an inflammasome. The AIM2 PYD structure illustrates distinct charge distribution and a unique hydrophobic patch...
  9. Li T, Chen J, Cristea I. Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe. 2013;14:591-9 pubmed publisher
    ..Collectively, our data elucidate the interplay between host DNA sensing and HCMV immune evasion, providing targets for restoring antiviral immunity...

More Information

Publications121 found, 100 shown here

  1. Landolfo S, Gariglio M, Gribaudo G, Lembo D. The Ifi 200 genes: an emerging family of IFN-inducible genes. Biochimie. 1998;80:721-8 pubmed
    ..related genes located on murine chromosome 1 (Ifi 200 cluster) and three homologous genes (MNDA, IFI 16 and AIM2) located on human chromosome 1 as well, within a linkage group highly conserved between mouse and human...
  2. Chen I, Ou Yang F, Hung J, Liu J, Wang H, Wang S, et al. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol Cancer Ther. 2006;5:1-7 pubmed
    ..The human IFN-inducible protein absent in melanoma 2 (AIM2) gene encodes a 39-kDa protein, which contains a 200-amino-acid repeat as a signature of HIN-200 family (..
  3. Fernandes Alnemri T, Yu J, Datta P, Wu J, Alnemri E. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009;458:509-13 pubmed publisher
    ..The nature of the cytoplasmic-DNA-sensing inflammasome is currently unknown. Here we show that AIM2 (absent in melanoma 2), an interferon-inducible HIN-200 family member that contains an amino-terminal pyrin domain ..
  4. Jin T, Perry A, Jiang J, Smith P, Curry J, Unterholzner L, et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity. 2012;36:561-71 pubmed publisher
    ..b>AIM2 (absent in melanoma 2) and IFI16 (interferon-inducible protein 16) have been identified as DNA receptors that ..
  5. Reinholz M, Kawakami Y, Salzer S, Kreuter A, Dombrowski Y, Koglin S, et al. HPV16 activates the AIM2 inflammasome in keratinocytes. Arch Dermatol Res. 2013;305:723-32 pubmed publisher
    ..Binding of viral DNA leads to AIM2 inflammasome activation and IL-1? release, while IFI16 activation results in IFN-? release...
  6. Man S, Place D, Kuriakose T, Kanneganti T. Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation. J Leukoc Biol. 2017;101:143-150 pubmed publisher
    ..In response to certain cytosolic bacteria, GBPs liberate microbial DNA for activation of the DNA-sensing AIM2 inflammasome...
  7. Luo F, Liu H, Yang S, Fang Y, Zhao Z, Hu Y, et al. Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production. J Immunol. 2019;202:2254-2265 pubmed publisher
    ..Moreover, AMN107 suppresses gene expression of absent in melanoma 2 (AIM2) and subsequently reduces inflammasome activation induced by cytosolic bacteria, dsDNA, and DNA viruses...
  8. Youm Y, Nguyen K, Grant R, Goldberg E, Bodogai M, Kim D, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;21:263-9 pubmed publisher
    ..in response to pathogens that activate the NLR family, CARD domain containing 4 (NLRC4) or absent in melanoma 2 (AIM2) inflammasome and did not affect non-canonical caspase-11, inflammasome activation...
  9. Man S, Karki R, Briard B, Burton A, Gingras S, Pelletier S, et al. Differential roles of caspase-1 and caspase-11 in infection and inflammation. Sci Rep. 2017;7:45126 pubmed publisher
    ..or non-canonical NLRP3 activators LPS and ATP, Escherichia coli, Citrobacter rodentium and transfection of LPS, AIM2 activators Francisella novicida, mouse cytomegalovirus and DNA, and the infectious agents Listeria monocytogenes ..
  10. Shin W, Shim D, Kim M, Sun X, Koppula S, Yu S, et al. Protective effects of Cinnamomum cassia (Lamaceae) against gout and septic responses via attenuation of inflammasome activation in experimental models. J Ethnopharmacol. 2017;205:173-177 pubmed publisher
    ..rate in the LPS-induced septic shock mouse model and inhibited inflammasome activation including NLRP3, NLRC4, and AIM2, leading to suppression of interleukin-1β secretion...
  11. Rahman M, McFadden G. Myxoma virus lacking the pyrin-like protein M013 is sensed in human myeloid cells by both NLRP3 and multiple Toll-like receptors, which independently activate the inflammasome and NF-κB innate response pathways. J Virol. 2011;85:12505-17 pubmed publisher
    ..of NF-κB signaling, which induces TNF secretion, was independent of ASC, caspase-1, and either the NLRP3 or AIM2 inflammasome receptors...
  12. Moon J, Nakahira K, Chung K, DeNicola G, Koo M, Pabón M, et al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat Med. 2016;22:1002-12 pubmed publisher
    ..inhibit the activation of the NLR family, CARD-domain-containing 4 (NLRC4), the NLRP1 or the absent in melanoma 2 (AIM2) inflammasomes. We also found that inhibition of FAO by etomoxir treatment suppressed NLRP3 inflammasome activation...
  13. Chen C, Chen C, Liu C, Chen C. Omega-3 polyunsaturated fatty acids reduce preterm labor by inhibiting trophoblast cathepsin S and inflammasome activation. Clin Sci (Lond). 2018;132:2221-2239 pubmed publisher
    ..and activated NLRP1 (nacht domain-leucine-rich repeat, and pyd-containing protein 1) and absent in melanoma 2 (AIM2) inflammasomes, thereby increasing IL-1β secretion...
  14. Eichholz K, Bru T, Tran T, Fernandes P, Welles H, Mennechet F, et al. Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells. PLoS Pathog. 2016;12:e1005871 pubmed publisher
    ..VI-dependent endosomal escape is required for the HAdV genome to engage the DNA pattern recognition receptor AIM2 (absent in melanoma 2)...
  15. Luehong N, Khaowmek J, Wongsawan K, Chuammitri P. Preferential pattern of mouse neutrophil cell death in response to various stimulants. In Vitro Cell Dev Biol Anim. 2017;53:513-524 pubmed publisher
    ..of CASP1, IL1β, IL18, MCL1, NLRP3, and PYCARD was down-regulated in the PMA group, with the exception of AIM2 and CASP3...
  16. Ahmad F, Chung Y, Tang Y, Hockman S, Liu S, Khan Y, et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep. 2016;6:28056 pubmed publisher
    ..Ablation of PDE3B in WAT prevents inflammasome activation by reducing expression of NLRP3, caspase-1, ASC, AIM2, TNFα, IL1β and proinflammatory genes...
  17. Duffy E, Periasamy S, Hunt D, Drake J, Harton J. Fc?R mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes. J Leukoc Biol. 2016;100:1335-1347 pubmed
    ..Although iFt-mAb complexes bind Fc?R and are internalized, sensing of cytosolic DNA by absent in melanoma 2 (AIM2) is not required for the IL-1? response...
  18. Virreira Winter S, Zychlinsky A. The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species. J Biol Chem. 2018;293:4893-4900 pubmed publisher
    ..Of note, PCN did not regulate the AIM2 (absent in melanoma 2) or NLRC4 inflammasomes or tumor necrosis factor (TNF) secretion...
  19. Nour A, Reichelt M, Ku C, Ho M, Heineman T, Arvin A. Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex. J Biol Chem. 2011;286:17921-33 pubmed publisher
    ..Absent in melanoma gene-2 (AIM2) is an interferon-inducible protein that can form an alternative inflammasome complex with caspase-1 in virus-..
  20. Marchetti C, Swartzwelter B, Gamboni F, Neff C, Richter K, Azam T, et al. OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc Natl Acad Sci U S A. 2018;115:E1530-E1539 pubmed publisher
    ..The molecule showed no effect on the NLRC4 and AIM2 inflammasomes, suggesting specificity for NLRP3...
  21. Jung S, Moon J, Xu J, Ifedigbo E, Ryter S, Choi A, et al. Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages. Am J Physiol Lung Cell Mol Physiol. 2015;308:L1058-67 pubmed publisher
    ..In contrast, CO did not suppress IL-18 secretion in response to LPS and poly(dA:dT), an absent in melanoma 2 (AIM2)-mediated inflammasome model...
  22. Greaney A, Maier N, Leppla S, Moayeri M. Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. J Leukoc Biol. 2016;99:189-99 pubmed publisher
    ..protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors...
  23. Ding L, Dong G, Zhang D, Ni Y, Hou Y. The regional function of cGAS/STING signal in multiple organs: One of culprit behind systemic lupus erythematosus?. Med Hypotheses. 2015;85:846-9 pubmed publisher
    ..Currently, the nucleic acid receptors, such as Toll-like receptors, RIG-I-like receptors, AIM2-like receptors and IFI 200-family have been uncovered to be potential predisposing causes for SLE via triggering ..
  24. Periasamy S, Le H, Duffy E, Chin H, Harton J. Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia. PLoS Pathog. 2016;12:e1006059 pubmed publisher
    ..we show that both in vitro macrophage and in vivo IL-1β and IL-18 responses to Ft LVS and SchuS4 involve both the Aim2 and Nlrp3 inflammasomes...
  25. Stavrou S, Aguilera A, Blouch K, Ross S. DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection. MBio. 2018;9: pubmed publisher
    ..recently showed that the sensors cyclic GMP-AMP synthase (cGAS), DEAD-box helicase 41 (DDX41), and members of the Aim2-like receptor (ALR) family participate in the recognition of retroviral reverse transcripts...
  26. Bi J, Dai J, Koivisto L, Larjava M, Bi L, Hakkinen L, et al. Inflammasome and cytokine expression profiling in experimental periodontitis in the integrin β6 null mouse. Cytokine. 2019;114:135-142 pubmed publisher
    ..IL-18 mediates many effects of the AIM2 inflammasome, including regulation of the microbiome...
  27. Ahn H, Kim J, Kang S, Yoon S, Ko H, Kim P, et al. Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation. Sci Rep. 2018;8:13659 pubmed publisher
    ..metals, including cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb), on the activation of NLRP3, NLRC4, and AIM2 inflammasomes...
  28. Sand J, Haertel E, Biedermann T, Contassot E, Reichmann E, French L, et al. Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes. Cell Death Dis. 2018;9:24 pubmed publisher
    ..Whereas murine keratinocytes produced caspase-1 and proIL-18, expression of the inflammasome proteins Nlrp1, Nlrp3, Aim2, Asc, and proIL-1β was, compared to human keratinocytes or murine dendritic cells, very low or even undetectable...
  29. Seo D, Cho Y, Gu S, Kim D, Yi Y, Lee S. A hot-water extract of Sanguisorba officinalis ameliorates endotoxin-induced septic shock by inhibiting inflammasome activation. Microbiol Immunol. 2018;62:44-54 pubmed publisher
  30. Place D, Samir P, Karki R, Briard B, Vogel P, Kanneganti T. ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. Am J Pathol. 2018;188:1021-1030 pubmed publisher
    ..Our findings identify the ASK1/2 complex as a regulator of NLRP3 activation and highlight a larger role for ASK2 in lung infection during B. thailandensis infection. ..
  31. Zhang Q, Hu Q, Chu Y, Xu B, Song Q. The Influence of Radiotherapy on AIM2 Inflammasome in Radiation Pneumonitis. Inflammation. 2016;39:1827-34 pubmed publisher
    This study aims to investigate the influence of radiotherapy on absent in melanoma 2 (AIM2) inflammasome in radiation pneumonitis (RP). A rat model of RP was established...
  32. Pan J, Han L, Guo J, Wang X, Liu D, Tian J, et al. AIM2 accelerates the atherosclerotic plaque progressions in ApoE-/- mice. Biochem Biophys Res Commun. 2018;498:487-494 pubmed publisher
    ..Pyroptosis is a newly discovered form of programmed cell death. Absent in melanoma 2 (AIM2), a member of the HIN-200 protein family, plays an important role in activating inflammasomes...
  33. Patsos G, Andre S, Roeckel N, Gromes R, Gebert J, Kopitz J, et al. Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile. Glycobiology. 2009;19:726-34 pubmed publisher
    ..in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal ..
  34. Liu L, Yang M, Kang R, Dai Y, Yu Y, Gao F, et al. HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE. Biochem Biophys Res Commun. 2014;450:851-6 pubmed publisher
    ..In this study, we demonstrated that HMGB1-DNA complex initially induced absent in melanoma 2 (AIM2)-dependent inflammasome activation, and promoted rapid release of inflammasome-dependent early proinflammatory ..
  35. Chen J, Wang Z, Yu S. AIM2 regulates viability and apoptosis in human colorectal cancer cells via the PI3K/Akt pathway. Onco Targets Ther. 2017;10:811-817 pubmed publisher
    Absent in melanoma 2 (AIM2) plays an important role in innate immunity as a DNA sensor in the cytoplasm by triggering the assembly of an AIM2 inflammasome that results in caspase-1-mediated inflammatory responses and cell death...
  36. Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma B, et al. IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell. 2018;173:920-933.e13 pubmed publisher
    ..or Pseudomonas aeruginosa but is dispensable for activation of the canonical and non-canonical NLRP3, AIM2, and Pyrin inflammasomes...
  37. Kopfnagel V, Wittmann M, Werfel T. Human keratinocytes express AIM2 and respond to dsDNA with IL-1? secretion. Exp Dermatol. 2011;20:1027-9 pubmed publisher
    ..In this study, we investigated the presence and activity of the recently identified absent in melanoma 2 (AIM2) inflammasome in human keratinocytes...
  38. Alekseeva A, Kameneva L, Kostyuk S, Veiko N. Multiple Ways of cfDNA Reception and Following ROS Production in Endothelial Cells. Adv Exp Med Biol. 2016;924:127-131 pubmed
    ..a physiologically optimal concentration with HUVEC cells for 3-24 h and detected the expression of either TLR9 or AIM2, RIG1 and STING receptors at mRNA and protein levels...
  39. Hu S, Peng L, Kwak Y, Tekippe E, Pasare C, Malter J, et al. The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense. Cell Rep. 2015;13:1922-36 pubmed publisher
    ..However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown...
  40. Ma X, Guo P, Qiu Y, Mu K, Zhu L, Zhao W, et al. Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway. Oncotarget. 2016;7:36185-36197 pubmed publisher
    Absent in melanoma (AIM2) is a member of the interferon-inducible HIN-200 protein family and is recently recognized to play an important dual role in both innate immunity and tumor pathology...
  41. Gallucci S, Maffei M. DNA Sensing across the Tree of Life. Trends Immunol. 2017;38:719-732 pubmed publisher
    ..receptor 9 (TLR9) in the endosomal compartment and cyclic GMP-AMP synthase (cGAS) and absent in melanoma 2 (AIM2) in the cytoplasm. Sequence and structure also enhance recognition across species...
  42. Komada T, Chung H, Lau A, Platnich J, Beck P, Benediktsson H, et al. Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD. J Am Soc Nephrol. 2018;29:1165-1181 pubmed publisher
    Nonmicrobial inflammation contributes to CKD progression and fibrosis. Absent in melanoma 2 (AIM2) is an inflammasome-forming receptor for double-stranded DNA. AIM2 is expressed in the kidney and activated mainly by macrophages...
  43. Ji J, Xu J, Zhao S, Liu F, Qi J, Song Y, et al. Myeloid-derived suppressor cells contribute to systemic lupus erythaematosus by regulating differentiation of Th17 cells and Tregs. Clin Sci (Lond). 2016;130:1453-67 pubmed publisher
    ..reactive oxygen species) through increasing gp91(phox) expression, and activated TLR2 (Toll-like receptor 2) and AIM2 (absent in melanoma 2) inflammasome in M-MDSCs lead to IL-1? (interleukin 1?) expression in diseased MRL/lpr mice ..
  44. Chu J, Shi G, Fan Y, Choi I, Cha G, Zhou Y, et al. Production of IL-1? and Inflammasome with Up-Regulated Expressions of NOD-Like Receptor Related Genes in Toxoplasma gondii-Infected THP-1 Macrophages. Korean J Parasitol. 2016;54:711-717 pubmed publisher
    ..also upregulated the expression of inflammasome sensors, including NLRP1, NLRP3, NLRC4, NLRP6, NLRP8, NLRP13, AIM2, and NAIP, in a time-dependent manner...
  45. Choubey D. Absent in melanoma 2 proteins in the development of cancer. Cell Mol Life Sci. 2016;73:4383-4395 pubmed
    ..colitis-associated and sporadic colon cancer in mouse models indicated a protective role for absent in melanoma 2 (Aim2) in colon epithelial cells...
  46. Place D, Kanneganti T. Recent advances in inflammasome biology. Curr Opin Immunol. 2018;50:32-38 pubmed publisher
    ..of this complex often involves the adaptor protein ASC and upstream sensors including NLRP1, NLRP3, NLRC4, AIM2, and pyrin, which are activated by different stimuli including infectious agents and changes in cell homeostasis...
  47. Sohn J, Hur S. Filament assemblies in foreign nucleic acid sensors. Curr Opin Struct Biol. 2016;37:134-44 pubmed publisher
    ..review, we focus on the helical assemblies observed in the signaling pathways of RIG-I-like receptors (RLRs) and AIM2-like receptors (ALRs)...
  48. Silveira T, Gomes M, Oliveira L, Campos P, Machado G, Oliveira S. NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus. Eur J Immunol. 2017;47:51-59 pubmed publisher
    ..Our group recently demonstrated the role of AIM2 and NLRP3 in Brucella recognition. Here, we investigated the participation of NLRP12 in innate immune response to B...
  49. Plantier L, Renaud H, Respaud R, Marchand Adam S, Crestani B. Transcriptome of Cultured Lung Fibroblasts in Idiopathic Pulmonary Fibrosis: Meta-Analysis of Publically Available Microarray Datasets Reveals Repression of Inflammation and Immunity Pathways. Int J Mol Sci. 2016;17: pubmed
    ..Influenza A, tumor necrosis factor (TNF) mediated signaling pathway, interferon-inducible absent in melanoma2 (AIM2) inflammasome as well as Apoptosis...
  50. Dang E, McDonald J, Russell D, Cyster J. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017;171:1057-1071.e11 pubmed publisher
    ..by macrophages is required to prevent inflammasome activation by the DNA sensor protein absent in melanoma 2 (AIM2)...
  51. Xie J, Li Y, Shen X, Goh G, Zhu Y, Cui J, et al. Dampened STING-Dependent Interferon Activation in Bats. Cell Host Microbe. 2018;23:297-301.e4 pubmed publisher
    ..Combined with previous reports on bat-specific changes of other DNA sensors such as TLR9, IFI16, and AIM2, our findings shed light on bat adaptation to flight, their long lifespan, and their unique capacity to serve as a ..
  52. Yun M, Seo G, Lee J, Chae G, Lee S. Epigallocatechin-3-gallate attenuates the AIM2-induced secretion of IL-1β in human epidermal keratinocytes. Biochem Biophys Res Commun. 2015;467:723-9 pubmed publisher
    ..Keratinocytes are a major source of IL-1β and express absent in melanoma 2 (AIM2). AIM2 recognizes a double-stranded DNA and initiates the IL-1β-processing of inflammasome...
  53. Haneklaus M, O Neil J, Clark A, Masters S, O Neill L. The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome. J Biol Chem. 2017;292:6869-6881 pubmed publisher
    ..of NLRP3 by LPS, which is also accompanied by increased Caspase-1 and IL-1β cleavage upon NLRP3, but not AIM2 or NLRC4 inflammasome activation...
  54. Svensson A, Patzi Churqui M, Schlüter K, Lind L, Eriksson K. Maturation-dependent expression of AIM2 in human B-cells. PLoS ONE. 2017;12:e0183268 pubmed publisher
    Intracellular DNA- and RNA-sensing receptors, such as the IFN-inducible protein Absent in Melanoma 2 (AIM2), serve as host sensors against a wide range of infections...
  55. Zhen J, Zhang L, Pan J, Ma S, Yu X, Li X, et al. AIM2 mediates inflammation-associated renal damage in hepatitis B virus-associated glomerulonephritis by regulating caspase-1, IL-1?, and IL-18. Mediators Inflamm. 2014;2014:190860 pubmed publisher
    b>AIM2 plays an important role in innate immunity, but its role in regulating the immune response to hepatitis B virus (HBV) is unknown...
  56. Domiciano T, Wakita D, Jones H, Crother T, Verri W, Arditi M, et al. Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis. Sci Rep. 2017;7:41539 pubmed publisher
    ..We found that QUC inhibits IL-1β secretion by both the NLRP3 and AIM2 inflammasome in a dose dependent manner, but not the NLRC4 inflammasome...
  57. Vakrakou A, Boiu S, Ziakas P, Xingi E, Boleti H, Manoussakis M. Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren's syndrome fueled by inflammagenic DNA accumulations. J Autoimmun. 2018;91:23-33 pubmed publisher
    ..DNA build-up in various biologic compartments of SS patients and its correlation with the activity of NLRP3 and AIM2 inflammasomes...
  58. Jang J, Shin H, Lee J, Lee H, Kim E, Park S. An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp. Mediators Inflamm. 2015;2015:794143 pubmed publisher
    ..oligomerization domain-like receptors (NLRs), the retinoic acid-inducible gene-I-like receptors (RLRs), and the AIM2-like receptor (ALR)...
  59. Zannetti C, Roblot G, Charrier E, Ainouze M, Tout I, Briat F, et al. Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens. J Immunol. 2016;197:356-67 pubmed publisher
    ..Moreover, activation of KC in response to the absent in melanoma 2 (AIM2) inflammasome led to the production of IL-1? and IL-18, which activated IL-8 transcription and hepatic NK cell ..
  60. Ahn H, Lee G. Isorhamnetin and hyperoside derived from water dropwort inhibits inflammasome activation. Phytomedicine. 2017;24:77-86 pubmed publisher
    ..EWD attenuated secretion of interleukin (IL)-1? and formation of Asc pyroptosome resulting from NLRP3, NLRC4, and AIM2 inflammasome activation without interruption of cytokine transcription...
  61. Corrales L, Woo S, Williams J, McWhirter S, Dubensky T, Gajewski T. Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA. J Immunol. 2016;196:3191-8 pubmed publisher
    ..However, the impact of the other major pathway triggered by intracellular DNA, the absent in melanoma 2 (AIM2) inflammasome, on the functional output from the stimulator of IFN genes (STING) pathway is poorly understood...
  62. Asmussen A, Fink K, Busch H, Helbing T, Bourgeois N, Bode C, et al. Inflammasome and toll-like receptor signaling in human monocytes after successful cardiopulmonary resuscitation. Crit Care. 2016;20:170 pubmed publisher
    ..TLR4, interleukin-1 receptor-associated kinase (IRAK)3, IRAK4, NLR family pyrin domain containing (NLRP)1, NLRP3, AIM2, PYCARD, CASP1, and IL1B were determined by real-time quantitative PCR...
  63. Próchnicki T, Latz E. Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control. Cell Metab. 2017;26:71-93 pubmed publisher
    ..Defined bacterial or viral ligands have been identified for the inflammasome-forming receptors AIM2, NLRP1, and NLRC4. The signals activating other inflammasomes, NLRP3, NLRP6, and pyrin, are less well understood...
  64. Wu D, Xu G, Lu S, Ma B, Miao N, Liu X, et al. Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B. Hum Immunol. 2013;74:514-21 pubmed publisher
    The AIM2 (absent in melanoma 2) protein promotes host defenses against invading viruses and pathogenic bacteria through corresponding adapter molecules leading to the initiation of innate immune responses...
  65. Rommereim L, Subramanian N. AIMing 2 Curtail Cancer. Cell. 2015;162:18-20 pubmed publisher
    ..In this issue, Man et al. reveal that the intracellular innate sensor AIM2 regulates microbial and stem cell homeostasis in the gut to protect against colorectal cancer.
  66. Ray M, Su Y, Meltzer P, Trent J. Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma. Oncogene. 1996;12:2527-33 pubmed
    ..This novel approach should facilitate the identification of genes whose expression is causally related to the suppressed phenotype. ..
  67. Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E, Choubey D. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol Cancer Res. 2011;9:589-602 pubmed publisher
    The IFN-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic double-stranded DNA (dsDNA)...
  68. Peng K, Broz P, Jones J, Joubert L, Monack D. Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis. Cell Microbiol. 2011;13:1586-600 pubmed publisher
    ..pathogens Francisella novicida and the Live Vaccine Strain (LVS) are recognized in the macrophage cytosol by the AIM2 inflammasome, which leads to the activation of caspase-1 and the processing and secretion of active IL-1?, IL-18 ..
  69. Diner B, Li T, Greco T, Crow M, Fuesler J, Wang J, et al. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 2015;11:787 pubmed publisher
    The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized...
  70. Zhang H, Luo J, Alcorn J, Chen K, Fan S, Pilewski J, et al. AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality. J Immunol. 2017;198:4383-4393 pubmed publisher
    The absent in melanoma 2 (AIM2) inflammasome plays an important role in many viral and bacterial infections, but very little is known about its role in RNA virus infection, including influenza A virus (IAV)...
  71. Mo W, Liu J, Zhang Z, Yu H, Yang A, Qu F, et al. A study of single nucleotide polymorphisms in CD157, AIM2 and JARID2 genes in Han Chinese children with autism spectrum disorder. Nord J Psychiatry. 2017;:1-5 pubmed publisher
    ..The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes related to immune function were associated with ASD in Chinese Han children...
  72. Kimkong I, Avihingsanon Y, Hirankarn N. Association of IFI200 gene polymorphisms with susceptibility to systemic lupus erythematosus. J Rheumatol. 2010;37:1544-7 pubmed publisher
  73. Ponomareva L, Liu H, Duan X, Dickerson E, Shen H, Panchanathan R, et al. AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer. Mol Cancer Res. 2013;11:1193-202 pubmed publisher
    ..Recent studies have indicated that the IFN-inducible AIM2 protein is a cytosolic DNA sensor in macrophages and keratinocytes...
  74. Akula M, Shi M, Jiang Z, Foster C, Miao D, Li A, et al. Control of the innate immune response by the mevalonate pathway. Nat Immunol. 2016;17:922-9 pubmed publisher
    ..or p110? exhibited constitutive release of interleukin 1? that was dependent on MEFV but independent of the NLRP3, AIM2 and NLRC4 inflammasomes...
  75. Liu T, Tang Q, Liu K, Xie W, Liu X, Wang H, et al. TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy. Cell Rep. 2016;16:1988-2002 pubmed publisher
    The AIM2 inflammasome is a key cytosolic signaling complex that is activated by double-stranded DNA, leading to the maturation of proinflammatory cytokines such as interleukin-1? (IL-1?) and IL-18...
  76. Yogarajah T, Ong K, Perera D, Wong K. AIM2 Inflammasome-Mediated Pyroptosis in Enterovirus A71-Infected Neuronal Cells Restricts Viral Replication. Sci Rep. 2017;7:5845 pubmed publisher
    ..We investigated the role of absent in melanoma 2 (AIM2) inflammasome in neuronal cell death, and its relationship to viral replication...
  77. Gaidt M, Ebert T, Chauhan D, Ramshorn K, Pinci F, Zuber S, et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017;171:1110-1124.e18 pubmed publisher
    ..a bipartite mode of cytosolic DNA recognition, in which the cGAS-STING axis triggers antiviral immunity, whereas AIM2 triggers inflammasome activation...
  78. Huang S, Song Z, Huang Q, Jiang L, Chen L, Wang R, et al. AIM2 Inflammasome Is Critical for dsDNA-Induced IL-1β Secretion in Human Dental Pulp Cells. Inflammation. 2018;41:409-417 pubmed publisher
    The AIM2 inflammasome pathway has been determined to play an important role in cellular immune defense against bacterial and viral infections; however, its function and regulatory mechanism in human dental pulp cells (HDPCs) during ..
  79. Alnemri E. Sensing cytoplasmic danger signals by the inflammasome. J Clin Immunol. 2010;30:512-9 pubmed publisher
    ..Absent in melanoma 2 (AIM2) is a newly discovered PRR involved in the sensing of dangerous cytosolic DNA produced by infection with DNA ..
  80. Hou X, Niu X. The NMR solution structure of AIM2 PYD domain from Mus musculus reveals a distinct α2-α3 helix conformation from its human homologues. Biochem Biophys Res Commun. 2015;461:396-400 pubmed publisher
    ..Cytosolic protein absent in melanoma 2 (AIM2) has been reported to play an essential role in double-stranded DNA (dsDNA) sensing and inflammasome formation in ..
  81. Hu G, Song P, Chen W, Qi S, Yu S, Du C, et al. Cirtical role for Salmonella effector SopB in regulating inflammasome activation. Mol Immunol. 2017;90:280-286 pubmed publisher
    ..BMDMs from NLRC4-, NLRP3-, caspase-1/-11-, IFI16- and AIM2-deficient mice were pretreated with LPS, and subsequently stimulated with a series of SopB-related strains of ..
  82. Wallet P, Benaoudia S, Mosnier A, Lagrange B, Martin A, Lindgren H, et al. IFN-? extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection. PLoS Pathog. 2017;13:e1006630 pubmed publisher
    ..GBPs have been functionally linked to the NLRP3, the AIM2 and the caspase-11 inflammasomes...
  83. Sagulenko V, Vitak N, Vajjhala P, Vince J, Stacey K. Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8. J Mol Biol. 2018;430:238-247 pubmed publisher
    ..of caspase-1 has also been suggested, but here we show that caspase-8-deficient macrophages have no defect in AIM2 inflammasome-mediated caspase-1 activation, pyroptosis, and IL-1β cleavage...
  84. Zhang W, Cai Y, Xu W, Yin Z, Gao X, Xiong S. AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation. J Clin Immunol. 2013;33:925-37 pubmed publisher
    ..Correlation between the level of absent in melanoma 2 (AIM2), a cytoplasmic DNA receptor in the inflammasome pathway, and the clinical severity of SLE disease were analyzed in ..
  85. Yerramothu P, Vijay A, Willcox M. Inflammasomes, the eye and anti-inflammasome therapy. Eye (Lond). 2017;: pubmed publisher
    ..The role of NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes in the pathogenesis of ocular diseases such as glaucoma, age related macular degeneration (AMD), ..
  86. Lugrin J, Martinon F. The AIM2 inflammasome: Sensor of pathogens and cellular perturbations. Immunol Rev. 2018;281:99-114 pubmed publisher
    ..b>AIM2 is a member of innate immune sensors that detects the presence of DNA, arguably the most conserved molecules in ..
  87. Shaw N, Liu Z. Role of the HIN domain in regulation of innate immune responses. Mol Cell Biol. 2014;34:2-15 pubmed publisher
    ..Structures of the recently solved HIN domains reveal that these domains exhibit either absent in melanoma2 (Aim2) HIN-like or p202 HINa-like modes of DNA binding...
  88. Dihlmann S, Erhart P, Mehrabi A, Nickkholgh A, Lasitschka F, Böckler D, et al. Increased expression and activation of absent in melanoma 2 inflammasome components in lymphocytic infiltrates of abdominal aortic aneurysms. Mol Med. 2014;20:230-7 pubmed publisher
    ..speck-like protein with a caspase recruitment domain" (ASC), caspase-1, caspase-5 and "absent in melanoma 2" (AIM2) were detected by immunohistochemistry in both sporadic infiltrating lymphoid cells and lymphoid aggregates located ..
  89. Wang Q, Westra J, van der Geest K, Moser J, Bijzet J, Kuiper T, et al. Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly. Exp Gerontol. 2016;78:39-46 pubmed publisher
    ..NLRs), retinoic-acid-inducible gene-I like receptors (RLRs) and the cytosolic DNA sensor absent in melanoma 2 (AIM2). Blood was collected from 16 young (20-39 years) and 18 elderly (60-84 years) healthy participants...
  90. Gray E, Winship D, Snyder J, Child S, Geballe A, Stetson D. The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Immunity. 2016;45:255-66 pubmed publisher
    ..Multiple DNA sensors have been proposed to activate this pathway, including AIM2-like receptors (ALRs). Whether the ALRs are essential for activation of this pathway remains unknown...
  91. Huang Y, Ma D, Huang H, Lu Y, Liao Y, Liu L, et al. Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome. Virol J. 2017;14:34 pubmed publisher
    b>AIM2, a cytosolic DNA sensor, plays an important role during infection caused by pathogens with double-stranded DNA; however, its role in human cytomegalovirus (HCMV) infection remains unclear...
  92. Manils J, Fischer H, Climent J, Casas E, Garcia Martinez C, Bas J, et al. Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses. Sci Rep. 2017;7:11902 pubmed publisher
    ..Of note, the expression of Tlr9, Aim2 and Tmem173, key DNA sensor genes, was markedly lower in keratinocytes and keratinocyte-built tissues than in ..