AIM1

Summary

Gene Symbol: AIM1
Description: absent in melanoma 1
Alias: CRYBG1, ST4, absent in melanoma 1 protein, beta-gamma crystallin domain containing 1, beta/gamma crystallin domain-containing protein 1, suppression of tumorigenicity 4 (malignant melanoma)
Species: human

Top Publications

  1. doi Biomarkers for predicting the sensitivity of cancer cells to TRAIL-R1 agonistic monoclonal antibody
    Shinsuke Araki
    Pharmaceutical Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 10 Wadai, Tsukuba, Ibaraki 300 4293, Japan
    Cancer Lett 292:269-79. 2010
  2. pmc AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma
    M E Ray
    Laboratory of Cancer Genetics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:3229-34. 1997
  3. doi Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies
    J Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leukemia 23:1139-51. 2009
  4. pmc Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1)
    Penmatsa Aravind
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    J Mol Biol 381:509-18. 2008
  5. ncbi Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma
    M E Ray
    Department of Human Genetics, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Oncogene 12:2527-33. 1996
  6. ncbi [Placental mitochondrial respiratory function of native Tibetan at high altitude]
    Xiu xin Zhao
    Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China
    Zhonghua Yi Xue Za Zhi 87:894-7. 2007
  7. ncbi Fibrinogen Longmont: a dysfibrinogenemia that causes prolonged clot-based test results only when using an optical detection method
    J B Lefkowitz
    Department of Pathology, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Hematol 63:149-55. 2000
  8. pmc Development and evaluation of a real-time PCR assay for detection and quantification of blastocystis parasites in human stool samples: prospective study of patients with hematological malignancies
    Philippe Poirier
    Clermont Universite, JE 2526, Evolution des bactéries pathogènes et susceptibilité de l hôte, BP 10448, F 63000 Clermont Ferrand, France
    J Clin Microbiol 49:975-83. 2011
  9. ncbi Cloning and tissue expression of the mouse ortholog of AIM1, a betagamma-crystallin superfamily member
    U Teichmann
    Laboratory for Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive MSC4472, Bethesda, Maryland 20892 4472, USA
    Mamm Genome 9:715-20. 1998
  10. ncbi The gene PPG encodes a novel yeast protein phosphatase involved in glycogen accumulation
    F Posas
    Departament de Bioquimica i Biologia Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Biol Chem 268:1349-54. 1993

Research Grants

  1. Customized Contact Lenses
    Geunyoung Yoon; Fiscal Year: 2010
  2. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura Gonzalez Bosc; Fiscal Year: 2009
  3. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2010
  4. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2010
  5. Identification of pancreatic cancer specific high affinity targeting ligands
    PAPPANAICKEN KUMARESAN; Fiscal Year: 2007
  6. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2009
  7. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
  8. The Role of Cks Proteins in Mammalian Meiosis
    Charles H Spruck; Fiscal Year: 2010
  9. The Role of Cks Proteins in Mammalian Meiosis
    Charles Spruck; Fiscal Year: 2009
  10. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004

Scientific Experts

  • Ewa Bien
  • Christen Rune Stensvold
  • Bernard Beall
  • Hiroshi Ichikawa
  • Antonio F Malheiros
  • Tamalee Roberts
  • David Ewan Connor
  • Benjamin Sivyer
  • Gemma L Chaloner
  • C Onyon
  • Nathalie D van Burgel
  • Hui Zheng
  • J B Lefkowitz
  • Evy Salcedo
  • T Saida
  • Akihiro Shima
  • Adam Baldwin
  • A Cignetti
  • Margarita Alegria
  • Eric Arts
  • Charles Spruck
  • Alan Friedman
  • Joseph Avruch
  • A Look
  • Karen Arndt
  • Maria Lehtinen
  • Karen M Arndt
  • Georges Mer
  • Gyongyi Szabo
  • M Elizabeth Sublette
  • Mariana Brait
  • ROBERT SCHOBORG
  • DIANA LYNNE GOLDEN
  • Laurent Coscoy
  • Abhishek Jaywant
  • Jacqueline F Bromberg
  • SAUL JOSEPH KARPEN
  • Maria Diakonova
  • Jeffrey J Borckardt
  • REGINA CARELLI
  • PAPPANAICKEN KUMARESAN
  • Geunyoung Yoon
  • Regina M Carelli
  • Karen Briley Saebo
  • Thomas Begley
  • A Thomas Look
  • Jacqueline Bromberg
  • Charles H Spruck
  • Lawrence L Rudel
  • Linda G Baum
  • Laura V Gonzalez Bosc
  • Laura Gonzalez Bosc
  • Eileen H Shinn
  • KAREN CATHERIN BRILEY SAEBO
  • JOSEPH MARK METZGER
  • Robert Hitzemann
  • THOMAS J contact BEGLEY
  • CHENG YUN KAREN LIU
  • Robert V Schoborg
  • Saul Karpen
  • ALEMJI TAKU
  • Eileen Shinn
  • Jeffrey Borckardt
  • Eric C Holland
  • Mohammed A Alfellani
  • Philippe Poirier
  • David Sidransky
  • Yogendra Sharma
  • Penmatsa Aravind
  • Yenlin Huang
  • Eli Rosenbaum
  • Mohammad O Hoque
  • Myriam Loyo
  • Frederic Delbac
  • Hicham El Alaoui
  • Shahnaz Begum
  • Shinobu Tsuzuki
  • C Graham Clark
  • Khalid Fahmy
  • Shashi Kumar Suman
  • Yitbarek Getachew
  • Laurence de Leval
  • Philippe Gaulard
  • Sojun Hoshimoto
  • Gitte M Knudsen
  • S Joseph
  • Marion Travert
  • Seung Gyu Lee
  • I Y Ozdemir
  • Ariadnna Cruz-Córdova

Detail Information

Publications93

  1. doi Biomarkers for predicting the sensitivity of cancer cells to TRAIL-R1 agonistic monoclonal antibody
    Shinsuke Araki
    Pharmaceutical Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 10 Wadai, Tsukuba, Ibaraki 300 4293, Japan
    Cancer Lett 292:269-79. 2010
    ..We have identified four genes (STK17B, SP140L, CASP8, and AIM1) whose expression levels differ significantly between TRAIL-R1 mAb-sensitive and resistant cell lines...
  2. pmc AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma
    M E Ray
    Laboratory of Cancer Genetics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:3229-34. 1997
    b>AIM1 is a novel gene whose expression is associated with the experimental reversal of tumorigenicity of human malignant melanoma. The predicted protein product of the major 4...
  3. doi Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies
    J Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leukemia 23:1139-51. 2009
    ..The minimal common region of deletion in 6q21 included three known genes (PRDM1, ATG5 and AIM1) showing generally low expression...
  4. pmc Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1)
    Penmatsa Aravind
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    J Mol Biol 381:509-18. 2008
    ..Absent in melanoma 1 (AIM1), an unusual member of the superfamily whose expression is associated with suppression of malignancy in melanoma, ..
  5. ncbi Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma
    M E Ray
    Department of Human Genetics, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Oncogene 12:2527-33. 1996
    ..One cDNA (termed AIM1) was localized to a band-region of chromosome 6 frequently deleted in melanomas (6q21)...
  6. ncbi [Placental mitochondrial respiratory function of native Tibetan at high altitude]
    Xiu xin Zhao
    Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China
    Zhonghua Yi Xue Za Zhi 87:894-7. 2007
    ..To explore the mitochondrial mechanism of adaptation to hypoxia of Tibetan...
  7. ncbi Fibrinogen Longmont: a dysfibrinogenemia that causes prolonged clot-based test results only when using an optical detection method
    J B Lefkowitz
    Department of Pathology, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Hematol 63:149-55. 2000
    ..end point using an optical detection method (ACL3000+) and a normal PT using an electromechanical detection method (ST4 Clot Detection System)...
  8. pmc Development and evaluation of a real-time PCR assay for detection and quantification of blastocystis parasites in human stool samples: prospective study of patients with hematological malignancies
    Philippe Poirier
    Clermont Universite, JE 2526, Evolution des bactéries pathogènes et susceptibilité de l hôte, BP 10448, F 63000 Clermont Ferrand, France
    J Clin Microbiol 49:975-83. 2011
    ..0%) prevalence of ST4. Two unexpected avian subtypes were found, i.e...
  9. ncbi Cloning and tissue expression of the mouse ortholog of AIM1, a betagamma-crystallin superfamily member
    U Teichmann
    Laboratory for Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive MSC4472, Bethesda, Maryland 20892 4472, USA
    Mamm Genome 9:715-20. 1998
    We report the isolation of the murine ortholog of AIM1, a human gene whose expression is associated with the reversal of tumorigenicity in an experimental model of melanoma...
  10. ncbi The gene PPG encodes a novel yeast protein phosphatase involved in glycogen accumulation
    F Posas
    Departament de Bioquimica i Biologia Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Biol Chem 268:1349-54. 1993
    ..Among the sequences obtained, clone ST4-2 was found to code for a novel sequence related to previously known phosphatases...
  11. pmc Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes
    Chris Carrie
    Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia
    J Biol Chem 285:36138-48. 2010
    ..peroxisomes the absence of Mia40 leads to an absence of CSD3 and a decrease in abnormal inflorescence meristem 1 (Aim1), a β-oxidation pathway enzyme. Inactivation of Mia40 leads to an alteration of the transcriptome of A...
  12. pmc A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma
    Myriam Loyo
    Department of Otolaryngology Head and Neck Surgery, Greater Baltimore Medical Center, Baltimore, MD 21231, USA
    Int J Cancer 128:1393-403. 2011
    ..The methylation status of AIM1, APC, CALCA, deleted in colorectal carcinomas (DCC), DLEC, deleted in liver cancer 1 (DLC1), estrogen receptor ..
  13. pmc Aberrant promoter methylation of multiple genes during pathogenesis of bladder cancer
    Mariana Brait
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II, 5M, Baltimore, MD 21231, USA
    Cancer Epidemiol Biomarkers Prev 17:2786-94. 2008
    ..The aims of our study were to elucidate the role of methylation of a large panel of genes during multistage pathogenesis of bladder cancer and to correlate our findings with patient age and other clinicopathologic features...
  14. doi Variable geographic distribution of Blastocystis subtypes and its potential implications
    Mohammed A Alfellani
    Pathogen Molecular Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Acta Trop 126:11-8. 2013
    ..b>ST4 was absent in Libya and ST2 in Nigeria, while no ST5, ST6, ST8 or ST9 infections were detected in any of the three ..
  15. doi Thyroid autoimmunity associated with recurrent aphthous stomatitis
    I Y Ozdemir
    Department of Dermatology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey
    J Eur Acad Dermatol Venereol 26:226-30. 2012
    ..TH1 cytokines plays a key role in the aetiopathogenesis. Autoimmune thyroid disease (ATD) is the most common autoimmune disease and is frequently accompanied by various other autoimmune diseases...
  16. ncbi Sequence of the small subunit of yeast carbamyl phosphate synthetase and identification of its catalytic domain
    H Nyunoya
    J Biol Chem 259:9790-8. 1984
    ..Two of the plasmids, pJL113/ST4 and pJL113/ST15, contain DNA inserts in opposite orientations with overlapping sequences of 2.6 kilobases...
  17. pmc Age-related changes in cochlear gene expression in normal and shaker 2 mice
    Tzy Wen L Gong
    Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 0648, USA
    J Assoc Res Otolaryngol 7:317-28. 2006
    ..Microarray data analyzed using Robust Multiarray Average identified Aim1, Dbi, and Tm4sf3 as genes with increased expression in sh2/sh2 homozygotes...
  18. pmc Genetic variability of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis isolates from humans, chickens, and pigs in Malaysia
    Yitbarek Getachew
    Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor DE, Malaysia
    Appl Environ Microbiol 79:4528-33. 2013
    ..E. faecalis isolates were more diverse and were identified as ST4, ST6, ST87, ST108, ST274, and ST244, which were grouped as specific to the three hosts. E...
  19. doi Molecular underpinning of extranodal NK/T-cell lymphoma
    Yenlin Huang
    Department of Anatomic Pathology, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, 33305 Taoyuan, Taiwan
    Best Pract Res Clin Haematol 26:57-74. 2013
    ..Frequent deletions and promoter methylations in PRDM1, ATG5, AIM1, FOXO3, HACE1 mapping to 6q21-q25, suggest their roles as potential tumor suppressors...
  20. pmc Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets
    Marion Travert
    INSERM U955, Creteil, France
    Blood 119:5795-806. 2012
    ..receptor 5 involved in cell trafficking, and the tyrosine kinase SYK, whereas the tumor-suppressor gene AIM1 (absent in melanoma 1) was among the most down-expressed...
  21. doi A third mode of surface-associated growth: immobilization of Salmonella enterica serovar Typhimurium modulates the RpoS-directed transcriptional programme
    Gitte M Knudsen
    Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK
    Environ Microbiol 14:1855-75. 2012
    ..The transcriptional programme and metabolomic profile of Salmonella enterica serovar Typhimurium ST4/74 were compared during planktonic and immobilized growth, and a number of immobilization-specific characteristics ..
  22. ncbi Proteomic analysis of proteins increased or reduced by ethanol of Lactobacillus plantarum ST4 isolated from Makgeolli, traditional Korean rice wine
    Seung Gyu Lee
    Division of Applied Life Science BK21, Graduate School, Gyeongsang National University, Jinju 660 701, Korea
    J Microbiol Biotechnol 22:516-25. 2012
    ..All 11 isolates were identified as Lactobacillus plantarum. Among them, ST4 grew in MRS broth with ethanol up to 10%, showing the highest alcohol resistance. L...
  23. pmc Flagella from five Cronobacter species induce pro-inflammatory cytokines in macrophage derivatives from human monocytes
    Ariadnna Cruz-Córdova
    Laboratorio de Bacteriología Intestinal, Departamento de Infectologia, Hospital Infantil de Mexico Federico Gomez, Mexico D F, Mexico
    PLoS ONE 7:e52091. 2012
    ..We investigated the role of flagella from C. sakazakii ST1 and ST4, C. malonaticus, C. muytjensii, C. turicensis and C...
  24. pmc AIM1 and LINE-1 epigenetic aberrations in tumor and serum relate to melanoma progression and disease outcome
    Sojun Hoshimoto
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    J Invest Dermatol 132:1689-97. 2012
    ..Promoter methylation status in long interspersed nucleotide element-1 (LINE-1) and absent in melanoma-1 (AIM1; 6q21) associated with melanoma progression and disease outcome was assessed...
  25. doi Expression analysis of a family of developmentally-regulated cytosolic sulfotransferases (SULTs) in Drosophila
    Khalid Fahmy
    Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Hereditas 150:44-8. 2013
    ..st1, st3 and st4 are expressed in non-overlapping expression domains mainly confined to organs of the alimentary canal such as ..
  26. pmc Diversity of the Cronobacter genus as revealed by multilocus sequence typing
    S Joseph
    Pathogen Research Group, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom
    J Clin Microbiol 50:3031-9. 2012
    ..The predominant species from clinical sources was found to be C. sakazakii. C. sakazakii sequence type 4 (ST4) was the predominant sequence type of cerebral spinal fluid isolates from cases of meningitis.
  27. pmc Fusobacterium nucleatum apoptosis-inducing outer membrane protein
    C W Kaplan
    Molecular Biology Institute, Section of Periodontics, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Dent Res 84:700-4. 2005
    ..vector conferring thiamphenicol resistance (pHS31) to construct a mutant deficient in one of the homologs, aim1. Transcriptional analyses demonstrated disruption of aim1 expression, and phenotypic analyses revealed a 41% ..
  28. ncbi Microelectrode array biochip: tool for in vitro drug screening based on the detection of a drug effect on dopamine release from PC12 cells
    Hui Fang Cui
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543
    Anal Chem 78:6347-55. 2006
    ..study: the peak current of the first KCl injection (Max1), and the steady current after the fourth KCl injection (St4)...
  29. doi Diversity and distribution of Blastocystis sp. subtypes in non-human primates
    Mohammed A Alfellani
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasitology 140:966-71. 2013
    ..Excluding 20 mixed ST infections, 27% of the sequences belonged to ST1, 22% to ST2, 34% to ST3, 1% to ST4, 4% to ST5, 11% to ST8, <1% to ST13 and 1% to ST15...
  30. doi Disability for Function: Loss of Ca(2+)-Binding Is Obligatory for Fitness of Mammalian βγ-Crystallins
    Shashi Kumar Suman
    Centre for Cellular and Molecular Biology CCMB, CSIR, Uppal Road, Hyderabad 500007, India
    Biochemistry 52:9047-58. 2013
    ..Such loss of Ca(2+)-binding function in non-lens βγ-crystallins from mammals (e.g., AIM1 and Crybg3) raises the possibility of a trade-off in the evolutionary extinction of Ca(2+)-binding...
  31. pmc Correlation between BRAF mutation and promoter methylation of TIMP3, RARβ2 and RASSF1A in thyroid cancer
    Mariana Brait
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Epigenetics 7:710-9. 2012
    ..DAPK, hMLH1, ATM, S100, p16, CTNNB1, GSTP1, CALCA, TIMP3, TGFßR2, THBS1, MINT1, CTNNB1, MT1G, PAK3, NISCH, DCC, AIM1 and KIF1A. The PCR-based "mutector assay" was used to detect BRAF mutation. All p values reported are two sided...
  32. ncbi Fermented milk-starch and milk-inulin products as vehicles for lactic acid bacteria
    Angela Zuleta
    Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    Plant Foods Hum Nutr 59:155-60. 2004
    ..SLH6, and Streptococcus thermophilus ST4. Growth and acidification were followed in 3% powdered milk (M3), 3% milk-6% starch (M3-S6), and 3% milk-6% inulin (..
  33. pmc AIM1 promoter hypermethylation as a predictor of decreased risk of recurrence following radical prostatectomy
    Eli Rosenbaum
    Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Prostate 72:1133-9. 2012
    To evaluate the prognostic significance of six epigenetic biomarkers (AIM1, CDH1, KIF1A, MT1G, PAK3, and RBM6 promoter hypermethlation) in a homogeneous group of prostate cancer patients, following radical prostatectomy (RP).
  34. doi Subtype distribution of Blastocystis isolates from a variety of animals from New South Wales, Australia
    Tamalee Roberts
    Department of Microbiology, SydPath, St Vincent s Hospital, Victoria St, Darlinghurst, NSW, Australia
    Vet Parasitol 196:85-9. 2013
    ..was a total of 80 (18%) sequences from 18 species, and nine different subtypes were identified - ST1, ST2, ST3, ST4, ST5, ST7, ST11, ST12 and ST13...
  35. pmc Explosive expansion of betagamma-crystallin genes in the ancestral vertebrate
    Guido Kappé
    Biomolecular Chemistry 271, NCMLS, Radboud University Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Mol Evol 71:219-30. 2010
    ..The genome also encodes a non-lenticular protein containing betagamma-crystallin motifs, AIM1, also found in gnathostomes but not detectable in the uro- or cephalochordate genome...
  36. doi Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes
    Daniela Boselli
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, University of Turin, 10126 Turin, Italy
    Immunol Lett 134:17-25. 2010
    ..Malignant ST4 cells transduced with either wild-type or mutated receptor were able to grow in SCID mice, but only the ..
  37. ncbi The importance of steric zipper on the aggregation of the MVGGVV peptide derived from the amyloid beta peptide
    Liang Kai Chang
    Graduate Institute of Biotechnology National Taipei University of Technology, 1 Sec 3 Zhong Xiao E Rd, Taipei, Taiwan 10608
    J Biomol Struct Dyn 28:39-50. 2010
    ..We further proposed that the octameric structure (the SH2-ST4 model in this study) is the possible nucleus seed for MVGGVV protofibril formation...
  38. pmc The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2
    Susan Arent
    Protein Chemistry Group, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK 2500 Valby, Denmark
    J Biol Chem 285:24066-77. 2010
    ..Two multifunctional peroxisomal isozymes, MFP2 and AIM1, both with 2-trans-enoyl-CoA hydratase and l-3-hydroxyacyl-CoA dehydrogenase activities, function in mouse ear ..
  39. doi Genetic parameters for stayability in Murrah buffaloes
    Priscilla M Galeazzi
    São Paulo State University Animal Science Department Jaboticabal SP, Brazil
    J Dairy Res 77:252-6. 2010
    ..trait (ST) was defined as the female's ability to stay in the herd for one (ST1), two (ST2), three (ST3), four (ST4), five (ST5) or six years (ST6) after the first calving...
  40. pmc Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4
    Nathalie D van Burgel
    Department of Medical Microbiology, Centre of Infectious Diseases, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands
    BMC Microbiol 10:43. 2010
    ..One important immune escape mechanism for evading complement activation is the binding of complement regulators Factor H (CFH) or Factor H-like protein1 (FHL-1) to Complement Regulator-Acquiring Surface Proteins (CRASPs)...
  41. doi Subtype analysis of Blastocystis isolates from symptomatic patients in Egypt
    Laetitia Souppart
    INSERM U547, Institut Pasteur de Lille, Universite Lille Nord de France, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Parasitol Res 106:505-11. 2010
    ..05%). Together with previous studies carried out in different areas in Egypt, a total of five STs (ST1, ST2, ST3, ST4, and ST6) have been found in symptomatic patients...
  42. doi Acupuncture benefits a pregnant patient who has Bell's palsy: a case study
    Hong Lei
    Institute of Integrated Traditional Chinese and Western Medicine, Wuhan, Hubei, People s Republic of China
    J Altern Complement Med 16:1011-4. 2010
    ..the qi sensation, and direct moxibustion with moxa sticks was performed at two points, Yangbai (GB14) and Dicang (ST4)...
  43. doi Dendritic morphology and tracer-coupling pattern of physiologically identified transient uniformity detector ganglion cells in rabbit retina
    Benjamin Sivyer
    ARC Centre of Excellence in Vision Science, Queensland Brain Institute, The University of Queensland, Brisbane, Australia
    Vis Neurosci 27:159-70. 2010
    ..Consistent with their unistratified medium-field morphology, these St4/5 amacrine cells appear to be GABAergic: their somata are immunopositive for GABA but immunonegative for glycine ..
  44. pmc Predominance of Cronobacter sakazakii sequence type 4 in neonatal infections
    Susan Joseph
    Nottingham Trent University, Nottingham, UK
    Emerg Infect Dis 17:1713-5. 2011
    ..Half (20/41) of the C. sakazakii strains were sequence type (ST) 4, and 9/12 meningitis isolates were ST4. C. sakazakii ST4 appears to be a highly stable clone with a high propensity for neonatal meningitis.
  45. doi Predominance of sequence type 1 group with serotype VI among group B streptococci with reduced penicillin susceptibility identified in Japan
    Kouji Kimura
    Department of Bacteriology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    J Antimicrob Chemother 66:2460-4. 2011
    ..In this study, PRGBS from Japan were characterized by multilocus sequence typing (MLST) and the results compared with data on PRGBS reported from the USA...
  46. doi Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses
    Kennosuke Karube
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 118:3195-204. 2011
    ..One of these regions included POPDC3, PREP, PRDM1, ATG5, and AIM1, whereas the other included LACE1 and FOXO3...
  47. doi G-CSF therapy and catheter-related Gram-positive sepsis increase serum IL-2 receptor α level and may falsely suggest a relapse in children with soft tissue sarcomas unless serum beta2-microglobulin, lactate dehydrogenase and C-reactive protein levels are
    Ewa Bien
    Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, 7 Debinki Street, 80 211 Gdansk, Poland
    Cytokine 55:347-52. 2011
    ..ST1), in complete remission (CR; ST2), in CR during G-CSF therapy (ST3), in CR during CVC-related sepsis (ST4), on relapse (ST5) and after treatment (ST6) and once in 50 healthy pediatric controls...
  48. pmc Blastocystis sp. subtype 4 is common in Danish Blastocystis-positive patients presenting with acute diarrhea
    Christen Rune Stensvold
    Laboratory of Parasitology, Department of Microbiological Diagnostics, Statens Serum Institut, Artillerivej 5, Copenhagen, Denmark
    Am J Trop Med Hyg 84:883-5. 2011
    ..A total of 25 patients (5.6%) were positive, and 19 of these patients (76.0%) were positive for Blastocystis sp. ST4. Because the relative prevalence of ST4 in other patients presenting with other types of diarrhea (persistent, ..
  49. pmc Multilocus sequence typing of Bartonella henselae in the United Kingdom indicates that only a few, uncommon sequence types are associated with zoonotic disease
    Gemma L Chaloner
    Department for Infection Biology, Institute for Infection and Global Health and School of Veterinary Science, University of Liverpool, South Wirral CH64 7TE, United Kingdom
    J Clin Microbiol 49:2132-7. 2011
    ..e., ST2, ST5, and ST8. Conversely, most (74%) of the feline isolates belonged to ST4, ST6, and ST7...
  50. pmc Short report: Molecular characterization of Blastocystis obtained from members of the indigenous Tapirapé ethnic group from the Brazilian Amazon region, Brazil
    Antonio F Malheiros
    Department of Biology, Mato Grosso State University, Caceres, Mato Grosso, Brazil
    Am J Trop Med Hyg 85:1050-3. 2011
    ..The subtype distribution was markedly different from that reported in Europe in that ST4 was not detected and ST3 was not the most common subtype...
  51. doi Molecular subtyping of Blastocystis sp. isolates from symptomatic patients in Italy
    Dionigia Meloni
    Center for Infection and Immunity of Lille CIIL, Institut Pasteur of Lille, Inserm U1019, CNRS UMR 8204, University Lille Nord de France, Biology and Diversity of Emerging Eukaryotic Pathogens BDEEP, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Parasitol Res 109:613-9. 2011
    ..1%), ST2 (20.6%), ST4 (17.7%), ST1 (8.8%), and ST7, and ST8 (2.9%)...
  52. doi Increased sampling reveals novel lineages of Entamoeba: consequences of genetic diversity and host specificity for taxonomy and molecular detection
    C Rune Stensvold
    Department of Microbiological Diagnostics, Statens Serum Institut, Artillerivej 3, DK 2300 Copenhagen S, Denmark
    Protist 162:525-41. 2011
    ..Entamoeba infecting humans is called Entamoeba polecki and divided into four subtypes (ST1-ST4) and that Entamoeba coli is divided into two subtypes (ST1-ST2)...
  53. doi Genes associated with long-chain omega-3 fatty acids in bovine skeletal muscle
    R Perez
    Department of Animal Production, Veterinary Faculty, Complutense University of Madrid, Spain
    J Appl Genet 51:479-87. 2010
    ..tested for nt821del11 and Q204X mutations) and the wild-type muscles for genes GDH1, IGF2R, FADS1, ASPH, and AIM1, all showing down-regulation in Asturiana de los Valles calves with muscle hypertrophy (GDF8-null)...
  54. pmc A defect in beta-oxidation causes abnormal inflorescence development in Arabidopsis
    T A Richmond
    Department of Botany, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Plant Cell 11:1911-24. 1999
    The abnormal inflorescence meristem1 (aim1) mutation affects inflorescence and floral development in Arabidopsis...
  55. doi Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke
    Hu Ding
    Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Stroke 41:177-80. 2010
    ..The first genomewide association study of ischemic stroke in whites has identified multiple susceptibility loci. We confirmed this study by examining associations with ischemic stroke in a Chinese Han population...
  56. ncbi The evolution of genes for pigmentation in African cichlid fishes
    Ayano Sugie
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Gene 343:337-46. 2004
    ..such pigment pattern diversity, we cloned the cichlid homologs of tyrosinase, endothelin receptor b1, mitf, and Aim1 that previously had been cloned and characterized from pigmentation mutants of zebrafish and medaka fish...
  57. pmc Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells
    Ellen D Cahir-McFarland
    The Channing Laboratory and Infectious Disease Division, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 78:4108-19. 2004
    ..Expression of IRF-2, AIM1, ASK1, SNF2L2, and components of IFN signaling pathways further distinguished EBV latency III-infected B cells from ..
  58. ncbi Mutations in the MATP gene in five German patients affected by oculocutaneous albinism type 4
    Uta Rundshagen
    Institut für Humangenetik der Universität Lübeck, Lubeck, Germany
    Hum Mutat 23:106-10. 2004
    ..OCA4 was described as a new form of OCA in a single patient with a splice site mutation in the MATP gene (or AIM1), the human ortholog of the murine underwhite gene...
  59. pmc A potential food-grade cloning vector for Streptococcus thermophilus that uses cadmium resistance as the selectable marker
    Wing Yee Wong
    DSM Food Specialties, Moorebank, New South Wales 2170, Australia
    Appl Environ Microbiol 69:5767-71. 2003
    ..thermophilus industrial strains tested, ST3-1 and ST4-1. Its relatively high retention rate in S...
  60. ncbi IGF-1 down-regulates IFN-gamma R2 chain surface expression and desensitizes IFN-gamma/STAT-1 signaling in human T lymphocytes
    Paola Bernabei
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, and Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
    Blood 102:2933-9. 2003
    ..of the IFN-gamma R2 chain and inhibited both IFN-gamma-dependent STAT-1 activation and apoptosis in T-cell lines ST4, Jurkat, and Molt-4...
  61. ncbi Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)
    Bheemreddy Rajini
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Biochemistry 42:4552-9. 2003
    b>AIM1 (absent in melanoma), a candidate suppressor of malignancy in melanoma, is a nonlens member of the betagamma-crystallin superfamily, which contains six predicted betagamma domains...
  62. ncbi Distinctive distribution of AIM1 polymorphism among major human populations with different skin color
    Kazuhiro Nakayama
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    J Hum Genet 47:92-4. 2002
    ..The gene for the AIM-1 protein (AIM1) was recently found to be responsible for the body color of medaka fish...
  63. ncbi Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka
    S Fukamachi
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa no ha 5 1 5, Kashiwa shi, Chiba ken 277 0882, Japan
    Nat Genet 28:381-5. 2001
    ..Here, we report the first successful positional cloning of a medaka gene (AIM1): one that encodes a transporter that mediates melanin synthesis...
  64. ncbi Recent advances in melanoma research
    T Saida
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621, Matsumoto, Japan
    J Dermatol Sci 26:1-13. 2001
    ..Deletions of PTEN/MMAC1 on 10q23.3 and AIM1 on 6q21 as well as mutations of ras gene are involved in the later progression stages of melanoma...
  65. pmc Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis
    C S Sorensen
    Danish Cancer Society, Institute of Cancer Biology, DK 2100 Copenhagen O, Denmark
    Mol Cell Biol 20:7613-23. 2000
    ..broad range of critical mitotic regulators including cyclin B1, cyclin A, Plk1, Pds1, mitosin (CENP-F), Aim1, and Cdc20...
  66. ncbi Interleukin-2 gene-transduced human leukemic cells induce major histocompatibility complex-restricted and -unrestricted anti-leukemic effectors in mixed lymphocyte-tumor cultures
    A Cignetti
    Dipartimento di Scienze Biomediche ed Oncologia Umana, University of Torino, Italy
    Cancer Gene Ther 7:167-76. 2000
    ..A lymphoblastic T-cell line, ST4, obtained from a patient in long-lasting complete remission, was retrovirally engineered with the IL-2, IL-7, and ..
  67. ncbi Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120)
    M Biard-Piechaczyk
    Laboratoire Infections Retrovirales et Signalisation Cellulaire, CNRS EP 2104, Institut de Biologie, 4 Boulevard Henri IV, Montpellier Cedex, 34060, France
    Virology 268:329-44. 2000
    ..Monoclonal antibodies directed against the gp120-binding site on CD4 (ST4) and against CXCR4 (MAB173) prevented the apoptotic signal in a dose-dependent manner...
  68. ncbi Expression of candidate cell death genes in cell lines during apoptosis
    G Hacker
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Biochem Cell Biol 72:451-4. 1994
    ..cell line (FDC-P1) that can be induced to undergo apoptosis by growth factor withdrawal and in a thymoma line (ST4) that undergoes apoptosis when irradiated...
  69. ncbi Immunoglobulin JH rearrangement in a T-cell line reflects fusion to the DH locus at a sequence lacking the nonamer recognition signal
    S Gerondakis
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Immunogenetics 28:255-9. 1988
    ..We have cloned and analyzed the JH rearrangements found on both alleles in the T lymphoma ST4. One represents conventional recombination between a member of the SP2 DH family and JH3...
  70. pmc Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120
    T K Hart
    Department of Experimental Pathology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406
    Proc Natl Acad Sci U S A 88:2189-93. 1991
    ..We demonstrate biochemically and morphologically that following binding, the soluble CD4 proteins sT4, V1V2,DT, and V1[106] (amino acids 1-369, 1-183, and -2 to 106 of mature CD4) induced the release of gp120 from HIV-..
  71. ncbi Construction of CD4-based chimeric molecules by chemical cross-linking
    T Idziorek
    , Bat. CERVI, , Paris, France
    AIDS Res Hum Retroviruses 7:529-36. 1991
    A simple method by which a soluble form of human CD4 (sT4) is chemically coupled to various carriers using a bifunctional reagent is described...
  72. ncbi Recombinant human soluble CD4 does not inhibit immune function in cynomolgus monkeys
    P J Bugelski
    Department of Experimental Pathology, SmithKline Beecham Pharmaceuticals, Philadelphia, Pennsylvania 19406
    Toxicol Pathol 19:580-8. 1991
    Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV...
  73. ncbi The Arabidopsis thaliana multifunctional protein gene (MFP2) of peroxisomal beta-oxidation is essential for seedling establishment
    Elizabeth L Rylott
    CNAP, Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Plant J 45:930-41. 2006
    ..A mutation in the abnormal inflorescence meristem gene AIM1, the only homologue of MFP2, results in an abnormal inflorescence meristem phenotype in mature plants (Richmond and ..
  74. pmc Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens
    Penmatsa Aravind
    Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:282-4. 2006
    AIM1g1 is a single betagamma-crystallin domain from the protein absent in melanoma 1 (AIM1), which appears to play a role in the suppression of melanomas...
  75. ncbi Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia: analysis by means of array-based comparative genomic hybridization
    Shinobu Tsuzuki
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:698-706. 2007
    ..2 (87%; TEL), 9p21.3 (29%; p16INK4a/ARF), 9p13.2 (25%; PAX5), 12q21.3 (25%; BTG1), 3p21 (21%; LIMD1), 6q21 (17%; AIM1 and BLIMP1), 4q31.23 (17%; NR3C2), 11q22-q23 (13%; ATM) and 19q13.11-q13.12 (13%; PDCD5)...
  76. pmc Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes
    Adam Baldwin
    Biological Sciences Department, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    BMC Microbiol 9:223. 2009
    ..sakazakii and 16 strains of C. malonaticus, including the index strains used to define the biotypes. The strains were from clinical and non-clinical sources between 1951 and 2008 in USA, Canada, Europe, New Zealand and the Far East...
  77. ncbi Reliability of multi-station interviews in selection of junior doctors for specialty training
    C Onyon
    Birmingham Children s Hospital NHS Foundation Trust, Steelhouse Lane, Birmingham B4 6NH, UK
    Med Teach 31:665-7. 2009
    ..Interviews for junior doctor training posts in the UK are considered high stakes assessments following the introduction of Modernizing Medical Careers...
  78. doi Genetic diversity of enterococci harboring the high-level gentamicin resistance gene aac(6')-Ie-aph(2'')-Ia or aph(2'')-Ie in a Japanese hospital
    Shojiro Watanabe
    Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan
    Microb Drug Resist 15:185-94. 2009
    ..Some E. faecalis STs (ST4, ST16, ST64, and ST223) were found in more than one strain, and ST4 and ST64 were associated with different IS256-..
  79. doi Detection of the procoagulant activity of microparticle-associated phosphatidylserine using XACT
    David E Connor
    Department of Haematology and Haematological Stem Cell Transplantation, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    Blood Coagul Fibrinolysis 20:558-64. 2009
    ..XACT testing for procoagulant phospholipid was measured using an ST4 machine and microparticle counting was performed using flow cytometry for Annexin V binding...
  80. doi Genotyping and in vitro antifungal susceptibility of Neoscytalidium dimidiatum isolates from different origins
    Hugo Madrid
    Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain
    Int J Antimicrob Agents 34:351-4. 2009
    ..were detected exclusively in isolates from plants, two (ST1 and ST5) were found only in clinical isolates and one (ST4) was observed in isolates from humans and from a mango tree. We propose subordinating S. hyalinum as a variety of N...
  81. doi TGFbetaR2 aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma
    Fabricio de Carvalho
    Discipline of Hematology and Hemotherapy, Universidade Federal de Sao Paulo, UNIFESP EPM, Sao Paulo, Brazil
    Int J Cancer 125:1985-91. 2009
    ..2%) are frequently hypermethylated in MM while aberrant methylation of RARbeta (16.6%), MGMT (12.5%), AIM1 (12.5%), CDKN2A (8.3%), SOCS1 (8.3%), CCNA1 (8.3%) and THBS1 (4.1%) are rare events...
  82. doi High prevalence of subtype 4 among isolates of Blastocystis hominis from symptomatic patients of a health district of Valencia (Spain)
    M Victoria Domínguez-Márquez
    Servicio de Microbiologia, Hospital Universitario de La Ribera, Alzira 46600, Spain
    Parasitol Res 105:949-55. 2009
    ..9%) and ST4 (94.1%)...
  83. doi Blastocystis: unravelling potential risk factors and clinical significance of a common but neglected parasite
    C R Stensvold
    Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark
    Epidemiol Infect 137:1655-63. 2009
    ..common in FU individuals (32%) than in NORMAT individuals (8%), whereas single subtype infections due to ST3 or ST4 were seen in 63% of the NORMAT cases and 28% of the FU cases...
  84. ncbi Evidence based acupuncture practice recommendations for peripheral facial paralysis
    Hui Zheng
    Department of Acupuncture and Moxibusion, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
    Am J Chin Med 37:35-43. 2009
    ..On the whole, when treating PFP, the best acupoints options are Dicang (ST4), Xiaguan (ST7), Jiache (ST6), Chengjiang (CV24), Yingxiang (LI20), Quanliao (SI18), Yifeng (TE17), Yangbai (GB14), ..
  85. doi Crosstalk between biotic and abiotic stress responses in tomato is mediated by the AIM1 transcription factor
    Synan Abuqamar
    Department of Botany and Plant Pathology, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Plant J 58:347-60. 2009
    ..Together, our data suggest SlAIM1 integrates plant responses to pathogens and abiotic stresses by modulating responses to ABA...
  86. ncbi [Perceived stress and its influence on the eating behaviours of students at the University of Moncton, Moncton Campus]
    Denise Daigle Leblanc
    nutrition alimentation, Universite de Moncton, Moncton, New Brunswick
    Can J Diet Pract Res 69:133-40. 2008
    Measure and analyze the link between perceived stress and eating behaviours of first (St1) and fourth-year students (St4) at the University of Moncton at the beginning (T1) and end (T2) of an academic trimester.
  87. doi Effect of acupuncture in a patient with 7-year-history of Bell's palsy
    Chau Lai Wong
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong
    J Altern Complement Med 14:847-53. 2008
    ..To demonstrate the effect of acupuncture in a child with chronic Bell's palsy of 7 years duration...
  88. doi Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia
    Soren Lehmann
    Department of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Cancer 112:1296-305. 2008
    ..Single nucleotide polymorphism (SNP) genomic array (SNP-chip) is a new tool that can detect copy number changes and uniparental disomy (UPD) over the entire genome with very high resolution...
  89. ncbi Normal pressure values and repeatability of the Emed ST4 system
    A B Putti
    Institute of Motion Analysis and Research IMAR, Division of Surgery and Oncology, TORT Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Gait Posture 27:501-5. 2008
    The aims of this study were to assess the repeatability of the Emed ST4 system and identify the range of pressure values observed in the normal foot. Fifty-three healthy subjects, 17 females (32%) and 36 males (68%), were recruited...
  90. ncbi Jasmonate biosynthesis in Arabidopsis thaliana requires peroxisomal beta-oxidation enzymes--additional proof by properties of pex6 and aim1
    Carolin Delker
    Leibniz Institute of Plant Biochemistry, Department of Natural Product Biotechnology, Weinberg 3, D 06120 Halle S, Germany
    Phytochemistry 68:1642-50. 2007
    ..We analyzed JA biosynthesis in the Arabidopsis mutants pex6, affected in peroxisome biogenesis, and aim1, disrupted in fatty acid beta-oxidation...
  91. ncbi Role in virulence and protective efficacy in pigs of Salmonella enterica serovar Typhimurium secreted components identified by signature-tagged mutagenesis
    Sonya C Carnell
    Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Microbiology 153:1940-52. 2007
    ..Typhimurium to colonize porcine intestines. A library of 1045 signature-tagged mutants of S. Typhimurium ST4/74 Nal(R) was screened following oral inoculation of pigs in duplicate...
  92. pmc A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release
    Mar Matarin
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 6:414-20. 2007
    ..We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same...
  93. ncbi Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma
    D Millikin
    Arizona Cancer Center, University of Arizona, Tucson 85724
    Cancer Res 51:5449-53. 1991
    ..These results have led us to conclude that the loss of sequences from the long arm of chromosome 6 is a nonrandom and possibly biologically relevant event in human malignant melanoma...

Research Grants67

  1. Customized Contact Lenses
    Geunyoung Yoon; Fiscal Year: 2010
    ..Our efforts during the next grant period are targeted at research that will overcome these limitations. Aim1.1 will stabilize the movement of customized soft contact lenses by sculpting the back surface profile to match the ..
  2. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura Gonzalez Bosc; Fiscal Year: 2009
    ..We will use the same animal models proposed in aim1 and determine mRNA and protein Kv isoforms; NFATc3 binding to KV 1.5 and 2...
  3. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2010
    ..We will use the same animal models proposed in aim1 and determine mRNA and protein Kv isoforms;NFATc3 binding to KV 1.5 and 2...
  4. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2010
    ..b>Aim1 will determine the role of JAK2-phosphorylated PAK1 in regulating PRL-dependent actin cytoskeleton rearrangement, ..
  5. Identification of pancreatic cancer specific high affinity targeting ligands
    PAPPANAICKEN KUMARESAN; Fiscal Year: 2007
    ..Time line 12 months 24 months Aim1 To synthesize several OBTC libraries Aim2 HTS stringent screening of high affinity ligands Aim3 Evaluation of ..
  6. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2009
    ..Here, 4 specific aims are proposed to build upon that work. Aim1 will use FSCV alone to determine if rapid DA release is altered during a cocaine/sucrose multiple schedule when ..
  7. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
    ..Here, 4 specific aims are proposed to build upon that work. Aim1 will use FSCV alone to determine if rapid DA release is altered during a cocaine/sucrose multiple schedule when ..
  8. The Role of Cks Proteins in Mammalian Meiosis
    Charles H Spruck; Fiscal Year: 2010
    ..Our hypothesis is that Cks2 performs analogous regulatory functions in mammalian Ml. Specific Aims: Aim1. Determine the role of Cks2 in regulating MPF and APC/C activity in Ml. Aim2...
  9. The Role of Cks Proteins in Mammalian Meiosis
    Charles Spruck; Fiscal Year: 2009
    ..Our hypothesis is that Cks2 performs analogous regulatory functions in mammalian Ml. Specific Aims: Aim1. Determine the role of Cks2 in regulating MPF and APC/C activity in Ml. Aim2...
  10. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..PU.1 mRNA was rapidly induced by C/EBPa-ER, even in the presence of cycloheximide. Thus, the central hypothesis of aim1 is that C/EBPa activates the PU.1 gene in normal hematopoietic cells. Cis elements in the PU...
  11. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Thomas Look; Fiscal Year: 2010
    ..In Aim1 we propose to elucidate the mechanistic basis of the synthetic-lethal relationship between p53 and chk1, by ..
  12. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Look; Fiscal Year: 2009
    ..In Aim1 we propose to elucidate the mechanistic basis of the synthetic-lethal relationship between p53 and chk1, by ..
  13. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Look; Fiscal Year: 2007
    ..In Aim1 we propose to elucidate the mechanistic basis of the synthetic-lethal relationship between p53 and chk1, by ..
  14. TMS in the Management of Postoperative Pain
    Jeffrey Borckardt; Fiscal Year: 2009
    ..Using rigorous double-masked methods and building on preliminary pilot work, we propose (Aim1) to test whether repetitive transcranial magnetic stimulation over the left prefrontal cortex significantly reduces ..
  15. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..Using rigorous double-masked methods and building on preliminary pilot work, we propose (Aim1) to test whether repetitive transcranial magnetic stimulation over the left prefrontal cortex significantly reduces ..
  16. Task space control of normal & pathological locomotion
    CHENG YUN KAREN LIU; Fiscal Year: 2010
    ..specific aims to study the use of task space control during locomotion are addressed: normal human locomotion (Aim1);pathological gait due to lower limb amputation (Aim2);and, the evaluation and simulation of the changes from ..
  17. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..e., "wounds that never heal" and thereby promote de novo tumorogenesis(Aim1)...
  18. Adherence to Swallowing Rehabilitation Exercises in Head and Neck Cancer
    Eileen Shinn; Fiscal Year: 2009
    ..Primary Aims Aim1) To compare the efficacy of a Self- Regulation intervention with an Enhanced Usual Care control group in increasing ..
  19. Adherence to Swallowing Rehabilitation Exercises in Head and Neck Cancer
    Eileen H Shinn; Fiscal Year: 2010
    ..Primary Aims Aim1) To compare the efficacy of a Self- Regulation intervention with an Enhanced Usual Care control group in increasing ..
  20. Troponin and Heart Function in Health and Disease
    JOSEPH MARK METZGER; Fiscal Year: 2010
    ..hypoxia responsive gene switch system, will permit translation of this proposal's molecular/cellular advances (Aim1) directly to the beating heart in vivo in pre-clinical studies in living mammals (Aim 2)...
  21. TRANSCRIPTION FACTOR MUTANTS OF YEAST
    Karen M Arndt; Fiscal Year: 2011
    ..Specific Aim1 is to determine the mechanism by which the Paf1 complex directs histone modifications...
  22. TRANSCRIPTION FACTOR MUTANTS OF YEAST
    Karen M Arndt; Fiscal Year: 2010
    ..Specific Aim1 is to determine the mechanism by which the Paf1 complex directs histone modifications...
  23. Structural Biology of Lysine Methylation in DNA Damage and Checkpoint Signaling
    Georges Mer; Fiscal Year: 2010
    ..In Aim1, we will test the hypothesis that 53BP1 simultaneously recognizes methylated H4-K20 and phosphorylated histone H2AX ..
  24. Impact of HIV-1 Fitness on Disease Progression
    Eric Arts; Fiscal Year: 2005
    ..In SPECIFIC AIM1, we will compete each patient isolate with four control HIV-1 strains to determine a relative ex vivo fitness value...