AIF

Summary

Gene Symbol: AIF
Description: apoptosis inducing factor mitochondria associated 1
Alias: AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, apoptosis-inducing factor 1, mitochondrial, apoptosis-inducing factor, mitochondrion-associated, 1, programmed cell death 8 (apoptosis-inducing factor), striatal apoptosis-inducing factor, testicular secretory protein Li 4
Species: human
Products:     AIF

Top Publications

  1. Wilkinson J, Wilkinson A, Galban S, Csomos R, Duckett C. Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP. Mol Cell Biol. 2008;28:237-47 pubmed
    ..molecules that participate with XIAP in regulating cellular activities, we identified apoptosis-inducing factor (AIF) as an XIAP binding protein...
  2. Desmots F, Russell H, Michel D, McKinnon P. Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis. J Biol Chem. 2008;283:3264-71 pubmed
    ..report here multiple levels of interaction between Scythe and the apoptogenic mitochondrial intermembrane protein AIF (apoptosis-inducing factor). Scythe physically interacts with AIF and regulates its stability...
  3. Joza N, Susin S, Daugas E, Stanford W, Cho S, Li C, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001;410:549-54 pubmed
    ..We have previously cloned a molecule associated with programmed cell death called apoptosis-inducing factor (AIF). Like cytochrome c, AIF is localized to mitochondria and released in response to death stimuli...
  4. Cande C, Cohen I, Daugas E, Ravagnan L, Larochette N, Zamzami N, et al. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie. 2002;84:215-22 pubmed
    Apoptosis-inducing factor (AIF) is a phylogenetically ancient mitochondrial intermembrane flavoprotein endowed with the unique capacity to induce caspase-independent peripheral chromatin condensation and large-scale DNA fragmentation ..
  5. Gallego M, Joseph B, Hemström T, Tamiji S, Mortier L, Kroemer G, et al. Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas. Oncogene. 2004;23:6282-91 pubmed
    ..In the NSCLC cell line U1810, STS induced the mitochondrial release of apoptosis-inducing factor (AIF) and cytochrome c (Cyt c) followed by activation of caspases, nuclear condensation, DNA fragmentation and finally ..
  6. Norberg E, Gogvadze V, Ott M, Horn M, Uhlen P, Orrenius S, et al. An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ. 2008;15:1857-64 pubmed publisher
    Apoptosis-inducing factor (AIF), a flavoprotein with NADH oxidase activity anchored to the mitochondrial inner membrane, is known to be involved in complex I maintenance...
  7. Schulthess F, Katz S, Ardestani A, Kawahira H, Georgia S, Bosco D, et al. Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. PLoS ONE. 2009;4:e4394 pubmed publisher
    ..A key mediator of apoptosis, mitochondrial function, and cell survival is apoptosis inducing factor (AIF)...
  8. Cande C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C, et al. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene. 2004;23:1514-21 pubmed
    Cyclophilin A (CypA) was determined to interact with apoptosis-inducing factor (AIF) by mass spectroscopy, coimmunoprecipitation, pull-down assays, and molecular modeling...
  9. Otera H, Ohsakaya S, Nagaura Z, Ishihara N, Mihara K. Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space. EMBO J. 2005;24:1375-86 pubmed
    Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane flavoprotein that is translocated to the nucleus in response to proapoptotic stimuli, where it induces nuclear apoptosis...

More Information

Publications107 found, 100 shown here

  1. Thal S, Zhu C, Thal S, Blomgren K, Plesnila N. Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice. Neurosci Lett. 2011;499:1-3 pubmed publisher
    ..In the current study we investigated the role of apoptosis-inducing factor (AIF), a major caspase-independent mitochondrial cell death protein, for neuronal cell death following global cerebral ..
  2. Susin S, Zamzami N, Castedo M, Daugas E, Wang H, Geley S, et al. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med. 1997;186:25-37 pubmed
    ..In addition, ICE-treated mitochondria release an apoptosis-inducing factor (AIF) that induces apoptotic changes (chromatin condensation and oligonucleosomal DNA fragmentation) in isolated nuclei ..
  3. Susin S, Lorenzo H, Zamzami N, Marzo I, Snow B, Brothers G, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999;397:441-6 pubmed
    ..Here we report the identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei...
  4. Daugas E, Susin S, Zamzami N, Ferri K, Irinopoulou T, Larochette N, et al. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J. 2000;14:729-39 pubmed
    Apoptosis inducing factor (AIF) is a novel apoptotic effector protein that induces chromatin condensation and large-scale ( approximately 50 kbp) DNA fragmentation when added to purified nuclei in vitro...
  5. Daugas E, Nochy D, Ravagnan L, Loeffler M, Susin S, Zamzami N, et al. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett. 2000;476:118-23 pubmed
    Apoptosis-inducing factor (AIF) is encoded by one single gene located on the X chromosome. AIF is ubiquitously expressed, both in normal tissues and in a variety of cancer cell lines...
  6. Vahsen N, Cande C, Briere J, Benit P, Joza N, Larochette N, et al. AIF deficiency compromises oxidative phosphorylation. EMBO J. 2004;23:4679-89 pubmed
    Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, after apoptosis induction, translocates to the nucleus where it participates in apoptotic chromatinolysis...
  7. Ghezzi D, Sevrioukova I, Invernizzi F, Lamperti C, Mora M, d Adamo P, et al. Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor. Am J Hum Genet. 2010;86:639-49 pubmed publisher
    ..We found a disease-segregating mutation in the X-linked AIFM1 gene, encoding the Apoptosis-Inducing Factor (AIF) mitochondrion-associated 1 precursor that deletes arginine 201 (R201 del)...
  8. Berger I, Ben Neriah Z, Dor Wolman T, Shaag A, Saada A, Zenvirt S, et al. Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing. Mol Genet Metab. 2011;104:517-20 pubmed publisher
    ..AIFM1 gene, extending the clinical spectrum to include prenatal ventriculomegaly and underscores the importance of AIF for complex I assembly...
  9. Fan T, Tian F, Yi S, Ke Y, Han S, Zhang L, et al. Implications of Bit1 and AIF overexpressions in esophageal squamous cell carcinoma. Tumour Biol. 2014;35:519-27 pubmed publisher
    Overwhelming evidence has demonstrated that Bit1 and AIF as mitochondrial proteins are implicated in the development and progression of a variety of tumors...
  10. Fatokun A, Dawson V, Dawson T. Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol. 2014;171:2000-16 pubmed publisher
    ..mechanistically dependent on the nuclear translocation of the mitochondrial-associated apoptosis-inducing factor (AIF)...
  11. Park E, Min K, Lee T, Yoo Y, Kim Y, Kwon T. ?-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells. Cell Death Dis. 2014;5:e1230 pubmed publisher
    ..In addition, ?-lapachone activated poly (ADP-ribosyl) polymerase-1(PARP-1) and promoted AIF release, and DPQ (a PARP-1 specific inhibitor) or AIF siRNA blocked ?-lapachone-induced cell death...
  12. Cheung E, Melanson Drapeau L, Cregan S, Vanderluit J, Ferguson K, McIntosh W, et al. Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci. 2005;25:1324-34 pubmed
    Mitochondria release proteins that propagate both caspase-dependent and caspase-independent cell death pathways. AIF (apoptosis-inducing factor) is an important caspase-independent death regulator in multiple neuronal injury pathways...
  13. Joza N, Pospisilik J, Hangen E, Hanada T, Modjtahedi N, Penninger J, et al. AIF: not just an apoptosis-inducing factor. Ann N Y Acad Sci. 2009;1171:2-11 pubmed publisher
    Since its discovery nearly a decade ago, apoptosis-inducing factor (AIF) has had anything but a staid and uneventful existence...
  14. Lewis E, Wilkinson A, Davis N, Horita D, Wilkinson J. Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation. Biochemistry. 2011;50:11084-96 pubmed publisher
    Apoptosis inducing factor (AIF) is a mediator of caspase-independent cell death that is also necessary for mitochondrial energy production. How these seemingly opposite cellular functions of AIF are controlled is poorly understood...
  15. Xie H, Li X, Chen Y, Lang M, Shen Z, Shi L. Ethanolic extract of Cordyceps cicadae exerts antitumor effect on human gastric cancer SGC-7901 cells by inducing apoptosis, cell cycle arrest and endoplasmic reticulum stress. J Ethnopharmacol. 2019;231:230-240 pubmed publisher
    ..Western blot analysis demonstrated that EEC increased Bax, AIF, caspase-8, caspase-6 and caspase-3 activities and decreased Bcl-2 activity...
  16. Chaves Neto A, Pelizzaro Rocha K, Fernandes M, Ferreira Halder C. Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O. Tumour Biol. 2015;36:595-604 pubmed publisher
    ..cellular inhibitor of apoptosis 1 (c-IAP1) expression, and increased expression of apoptosis-inducing factor (AIF)...
  17. Bonilla Porras A, Arevalo Arbelaez A, Alzate Restrepo J, Velez Pardo C, Jimenez Del Rio M. PARKIN overexpression in human mesenchymal stromal cells from Wharton's jelly suppresses 6-hydroxydopamine-induced apoptosis: Potential therapeutic strategy in Parkinson's disease. Cytotherapy. 2018;20:45-61 pubmed publisher
    ..1 (PINK1) protein and increased the expression of pro-apoptotic PUMA, caspase-3 and apoptosis-inducing factor (AIF). 6-OHDA exposure also significantly augmented the oxidation of the oxidative stress sensor, DJ-1...
  18. Yoo J, Lee B, Sok D, Ma J, Kim M. Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells. Redox Biol. 2017;11:592-599 pubmed publisher
    ..Moreover, NAS suppressed glutamate-induced apoptosis by suppressing expression of AIF, Bax, calpain, cytochrome c and cleaved caspase-3, whereas it enhanced expression of Bcl-2...
  19. Endesfelder S, Weichelt U, Strauß E, Schlör A, Sifringer M, Scheuer T, et al. Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..and NF?B), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and ..
  20. Cieślik M, Czapski G, Strosznajder J. The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins. PLoS ONE. 2015;10:e0137193 pubmed publisher
    ..Aβ1-42 significantly increased the level of mitochondrial proteins: apoptosis-inducing factor AIF and Sirt3, -4, -5...
  21. Song G, Valdez B, Li Y, Liu Y, Champlin R, Andersson B. Synergistic cytotoxicity of sorafenib with busulfan and nucleoside analogs in human FMS-like tyrosine kinase 3 internal tandem duplications-positive acute myeloid leukemia cells. Biol Blood Marrow Transplant. 2014;20:1687-95 pubmed publisher
    ..c, second mitochondria-derived activator of caspases (SMAC)/direct IAP Binding protein with low pI (DIABLO), and AIF from the mitochondria to the cytoplasm, caspase activation, and cell death, suggesting the activation of apoptosis...
  22. Wang L, Zhang S, Cheng H, Lv H, Cheng G, Ci X. Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK/Akt/GSK3? pathway. Free Radic Biol Med. 2016;101:401-412 pubmed publisher
    ..translocation and the release of mitochondrial inter-membrane proteins, such as apoptosis-inducing factor (AIF), but also by activating Nrf2/HO-1...
  23. Neve A, Trüb J, Saxena S, Schümperli D. Central and peripheral defects in motor units of the diaphragm of spinal muscular atrophy mice. Mol Cell Neurosci. 2016;70:30-41 pubmed publisher
  24. Wei Q, Luo Q, Liu H, Chen L, Cui H, Fang J, et al. The mitochondrial pathway is involved in sodium fluoride (NaF)-induced renal apoptosis in mice. Toxicol Res (Camb). 2018;7:792-808 pubmed publisher
    ..the serine protease high-temperature-requirement protein A2/Omi (HtrA2/Omi), the apoptosis inducing factor (AIF), endonuclease G (Endo G), cleaved-cysteine aspartate specific protease-9 (cleaved-caspase-9), cleaved-cysteine ..
  25. Basu M, Courtney S, Brinton M. Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells. PLoS Pathog. 2017;13:e1006240 pubmed publisher
    ..Knockdown of Nrf2, ATF4 or apoptosis-inducing factor (AIF), a mitochondrial protein involved in regenerating intracellular reduced glutathione (GSH) levels, with siRNA or ..
  26. Han B, Wang T, Shen S, Yu Y, Mao C, Yao Z, et al. Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism. BMC Cancer. 2015;15:139 pubmed publisher
    ..Immunofluorescence and subcellular fractionation were used to evaluate AIF nuclear translocation. Reactive oxygen species were assessed by using redox-sensitive dye DCFDA...
  27. Ruchalski K, Mao H, Singh S, Wang Y, Mosser D, Li F, et al. HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol. 2003;285:C1483-93 pubmed
    Inhibition of the mitochondrial release and nuclear translocation of apoptosis-inducing factor (AIF) by heat stress protein (HSP)72 may ameliorate apoptosis in renal epithelial cells exposed to a metabolic inhibitor...
  28. Huerta S, Heinzerling J, Anguiano Hernandez Y, Huerta Yepez S, Lin J, Chen D, et al. Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. J Surg Res. 2007;142:184-94 pubmed
    ..These genes may be potential targets for chemoradiosensitization in advanced colorectal cancer. ..
  29. Mishra D, Singh S, Narayan G. Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage. Asian Pac J Cancer Prev. 2016;17:3865-9 pubmed
    ..An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment...
  30. Yong W, Abd Malek S. Xanthohumol induces growth inhibition and apoptosis in ca ski human cervical cancer cells. Evid Based Complement Alternat Med. 2015;2015:921306 pubmed publisher
    ..On the other hand, Western blot analysis showed that the expression levels of cleaved PARP, p53, and AIF increased, while Bcl-2 and XIAP decreased in a dose-dependent manner...
  31. Jacobs M, Benovoy M, Chang L, Arai A, Hsu L. Evaluation of an automated method for arterial input function detection for first-pass myocardial perfusion cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2016;18:17 pubmed publisher
    ..first-pass perfusion cardiovascular magnetic resonance (CMR) requires a measurement of the arterial input function (AIF)...
  32. Li X, Zhang G, Chen Q, Lin Y, Li J, Ruan Q, et al. CD317 Promotes the survival of cancer cells through apoptosis-inducing factor. J Exp Clin Cancer Res. 2016;35:117 pubmed publisher
    ..in serum-deprived tumor cells impaired mitochondria function and subsequently promoted apoptosis-inducing factor (AIF) release and nuclear translocation but had little effect on mitochondrial and cytoplasmic distributions of ..
  33. Ge X, Hu C, Guo Q, Li W, Zhao Y, Yang W, et al. Investigation of the expression of apoptosis-inducing factor-mediated apoptosis in Hirschsprung's disease. Neuroreport. 2017;28:571-578 pubmed publisher
    ..Rather, real-time PCR results showed that apoptosis-inducing factor (AIF) and calpain-1 mRNAs were highly expressed in the transitional segment, whereas autophagy protein 5 (Atg5) was ..
  34. Chaleckis R, Naz S, Meister I, Wheelock C. LC-MS-Based Metabolomics of Biofluids Using All-Ion Fragmentation (AIF) Acquisition. Methods Mol Biol. 2018;1730:45-58 pubmed publisher
    ..Herein, we present a LC-MS method using the all-ion fragmentation (AIF) approach in combination with a data processing method using an in-house spectral library...
  35. Kim M, Ha T, Yoon J, Lee J. Myricetin induces cell death of human colon cancer cells via BAX/BCL2-dependent pathway. Anticancer Res. 2014;34:701-6 pubmed
    ..These results suggest that myricetin induces apoptosis of HCT-15 human colon cancer cells and may prove useful in the development of therapeutic agents for human colon cancer. ..
  36. Ardissone A, Piscosquito G, Legati A, Langella T, Lamantea E, Garavaglia B, et al. A slowly progressive mitochondrial encephalomyopathy widens the spectrum of AIFM1 disorders. Neurology. 2015;84:2193-5 pubmed publisher
  37. Claus C, Manssen L, Hübner D, Roßmark S, Bothe V, Petzold A, et al. Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection. Viruses. 2015;7:6108-26 pubmed publisher
    ..of the mitochondrial membrane and subsequent release of the pro-apoptotic proteins apoptosis-inducing factor (AIF) and cytochrome c from mitochondria...
  38. Yalçınkaya N, Haytural H, Bilgiç B, Özdemir Ã, HanaÄŸası H, Küçükali C, et al. Expression changes of genes associated with apoptosis and survival processes in Parkinson's disease. Neurosci Lett. 2016;615:72-7 pubmed publisher
    ..PBMC expression levels of AIFM1 might serve as a biomarker of disability and disease progression in PD. ..
  39. Rajski Å, Del Mar Gómez Ramos M, Fernández Alba A. Evaluation of MS2 workflows in LC-Q-Orbitrap for pesticide multi-residue methods in fruits and vegetables. Anal Bioanal Chem. 2017;409:5389-5400 pubmed publisher
    ..They were as follows: data-dependent MS2 (dd-MS2), all-ion fragmentation (AIF) and variable data-independent analysis (vDIA)...
  40. Ghezzi F, Monni L, Corsini S, Rauti R, Nistri A. Propofol Protects Rat Hypoglossal Motoneurons in an In Vitro Model of Excitotoxicity by Boosting GABAergic Inhibition and Reducing Oxidative Stress. Neuroscience. 2017;367:15-33 pubmed publisher
    ..in reactive oxygen species (ROS) and, at 4?hours, it inhibited intracellular release of apoptosis-inducing factor (AIF) and prevented concomitant cell loss. Midazolam did not contrast ROS and AIF release...
  41. Premkumar D, Jane E, Thambireddy S, Sutera P, Cavaleri J, Pollack I. Mitochondrial dysfunction RAD51, and Ku80 proteolysis promote apoptotic effects of Dinaciclib in Bcl-xL silenced cells. Mol Carcinog. 2018;57:469-482 pubmed publisher
    ..Dinaciclib was found to disrupt mitochondrial membrane potential, resulting in the release of cytochrome c, AIF, and smac/DIABLO into the cytoplasm. This was accompanied by the downregulation of cyclin-D1, D3, and total Rb...
  42. Ghodbane S, Ammari M, Lahbib A, Sakly M, Abdelmelek H. Static magnetic field exposure-induced oxidative response and caspase-independent apoptosis in rat liver: effect of selenium and vitamin E supplementations. Environ Sci Pollut Res Int. 2015;22:16060-6 pubmed publisher
    ..hepatocyte apoptosis through a caspase-independent pathway involving mitochondrial apoptosis-inducing factor (AIF) but not in the brain...
  43. Mehrabian H, Da Rosa M, Haider M, Martel A. Pharmacokinetic analysis of prostate cancer using independent component analysis. Magn Reson Imaging. 2015;33:1236-1245 pubmed publisher
    ..which cannot be measured directly at the tissue of interest, and is approximated with an arterial input function (AIF)...
  44. Sabirzhanov B, Stoica B, Zhao Z, Loane D, Wu J, Dorsey S, et al. miR-711 upregulation induces neuronal cell death after traumatic brain injury. Cell Death Differ. 2016;23:654-68 pubmed publisher
    ..component 3) and Bim (Bcl2-like 11 (apoptosis facilitator)), and mitochondrial release of cytochrome c and AIF. miR-711 and Akt (mRNA) co-immunoprecipitated with the RNA-induced silencing complex (RISC)...
  45. Mierzewska H, Rydzanicz M, Bieganski T, Kosinska J, Mierzewska Schmidt M, Ługowska A, et al. Spondyloepimetaphyseal dysplasia with neurodegeneration associated with AIFM1 mutation - a novel phenotype of the mitochondrial disease. Clin Genet. 2017;91:30-37 pubmed publisher
    ..AIFM1 encodes mitochondria associated apoptosis-inducing factor. The AIFM1 gene has been linked with COXPD6 encephalomyopathy (MIM 300816), Cowchock syndrome (MIM 310490) and X-linked deafness with neuropathy (DFNX5, MIM ..
  46. Wirestam R, Lind E, Ahlgren A, Stahlberg F, Knutsson L. Dynamic susceptibility contrast perfusion MRI using phase-based venous output functions: comparison with pseudo-continuous arterial spin labelling and assessment of contrast agent concentration in large veins. MAGMA. 2016;29:823-831 pubmed
    ..The pre-bolus phase-based venous output function (VOF) time integral was used for arterial input function (AIF) rescaling...
  47. Tica Sedlar I, Petricevic J, Saraga Babic M, Pintaric I, Vukojevic K. Apoptotic pathways and stemness in the colorectal epithelium and lamina propria mucosae during the human embryogenesis and carcinogenesis. Acta Histochem. 2016;118:693-703 pubmed publisher
    ..and high grade colorectal carcinomas (CRC), and 10 normal colon samples by using markers for apoptosis (caspase-3, AIF, TUNEL), proliferation (Ki-67) and stemness (Oct-4)...
  48. Cande C, Vahsen N, Metivier D, Tourrière H, Chebli K, Garrido C, et al. Regulation of cytoplasmic stress granules by apoptosis-inducing factor. J Cell Sci. 2004;117:4461-8 pubmed
    ..conditions of acute cellular redox, stress cells manipulated to lose the expression of apoptosis-inducing factor (AIF) nucleate SG signature proteins (e.g. TIA-1, PABP1) more efficiently than AIF-positive controls...
  49. Liu K, Huang Y, Wu P, Ji B, Yang J, Yang J, et al. The roles of AIF and Endo G in the apoptotic effects of benzyl isothiocyanate on DU 145 human prostate cancer cells via the mitochondrial signaling pathway. Int J Oncol. 2011;38:787-96 pubmed publisher
    ..Confocal laser microscopy examination indicated that BITC promoted the expression of AIF and Endo G, which were released from the mitochondria in DU 145 cells...
  50. Kanemura S, Tsuchiya A, Kanno T, Nakano T, Nishizaki T. Phosphatidylinositol Induces Caspase-Independent Apoptosis of Malignant Pleural Mesothelioma Cells by Accumulating AIF in the Nucleus. Cell Physiol Biochem. 2015;36:1037-48 pubmed publisher
    ..carried out, and mitochondrial membrane potentials and intracellular distribution of apoptosis-inducing factor (AIF) were monitored in cells with and without the siRNA silencing the Bid-targeted gene...
  51. Gupta S, Prasad G, Mukhopadhaya A. Vibrio cholerae Porin OmpU Induces Caspase-independent Programmed Cell Death upon Translocation to the Host Cell Mitochondria. J Biol Chem. 2015;290:31051-68 pubmed publisher
    ..of mitochondrial membrane potential, resulting in the release of cytochrome c and apoptosis-inducing factor (AIF). AIF translocates to the host cell nucleus, implying that it has a crucial role in OmpU-mediated cell death...
  52. Coughlan M, Higgins G, Nguyen T, Penfold S, Thallas Bonke V, Tan S, et al. Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis. Diabetes. 2016;65:1085-98 pubmed publisher
    Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein with dual roles in redox signaling and programmed cell death...
  53. Zhang B, Yan Y, Li Y, Zhang D, Zeng J, Wang L, et al. Dimethyl celecoxib sensitizes gastric cancer cells to ABT-737 via AIF nuclear translocation. J Cell Mol Med. 2016;20:2148-2159 pubmed publisher
    ..The translocation of apoptosis-inducing factor (AIF) from mitochondrion to nuclear was responsible for the induced apoptosis in the combination treatment...
  54. Tsai M, Chang W, Tsai P, Wu C, Ho Y, Yen M, et al. Montelukast Induces Apoptosis-Inducing Factor-Mediated Cell Death of Lung Cancer Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..up-regulation of Bcl-2 homologous antagonist/killer (Bak), and nuclear translocation of apoptosis-inducing factor (AIF) in montelukast-treated lung cancer cells...
  55. Lewis E, Wilkinson A, Jackson J, Mehra R, Varambally S, Chinnaiyan A, et al. The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells. J Biol Chem. 2012;287:43862-75 pubmed publisher
    Apoptosis-inducing factor (AIF) promotes cell death yet also controls mitochondrial homeostasis and energy metabolism...
  56. Rowell C, Kuiper N, Shomar B. Potential health impacts of consuming desalinated bottled water. J Water Health. 2015;13:437-45 pubmed publisher
    ..For children desalinated water contributed 2-3% of the IOM AICa, 3-10% of the RDA(Mg) and 3-9% of the AIF.
  57. Wu X, Cai J, Li X, Li H, Li J, Bai X, et al. Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway. Eur J Pharmacol. 2017;805:108-117 pubmed publisher
    ..of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla...
  58. Yang S, Zhao X, Xu H, Chen F, Xu Y, Li Z, et al. AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia. Int J Mol Sci. 2017;18: pubmed publisher
    ..observed as well as intracytosolic translocation of cytochrome C (Cyto C) together with apoptosis-inducing factor (AIF) and endonuclease G (EndoG), both of which are proven to conduct DNA degradation in a range of cell death stimuli...
  59. van Schie J, Lavini C, van Vliet L, Vos F. Estimating the arterial input function from dynamic contrast-enhanced MRI data with compensation for flow enhancement (I): Theory, method, and phantom experiments. J Magn Reson Imaging. 2017;: pubmed publisher
    The arterial input function (AIF) represents the time-dependent arterial contrast agent (CA) concentration that is used in pharmacokinetic modeling.
  60. Fan T, Hao Y, Xu P, Hou G, Jiang G, Yang G. [TAp63gamma-induced apoptosis mediated by apoptosis inducing factor in human esophageal squamous carcinoma EC9706 cells]. Zhonghua Bing Li Xue Za Zhi. 2007;36:384-9 pubmed
    ..Down-regulation of apoptosis inducing factor inhibits TAp63gamma-induced apoptosis. Overall, TAp63gamma-induced apoptosis is dependent on the expression of apoptosis inducing factor and caspase. ..
  61. Zhang H, Wang Z, Zhao D, Zheng D, Feng J, Song L, et al. AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis. Brain Res. 2011;1370:89-98 pubmed publisher
    ..the anti-apoptotic effects of the drug, which are mediated by specific regulation of apoptosis-inducing factor (AIF) in the process of oxygen and glucose deprivation (OGD)-induced apoptosis in SH-SY5Y cells...
  62. Piwko W, Olma M, Held M, Bianco J, Pedrioli P, Hofmann K, et al. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells. EMBO J. 2010;29:4210-22 pubmed publisher
    ..Together, our results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. ..
  63. Sabour Alaoui S, Dessirier V, de Araujo E, Alexaki V, Pelekanou V, Lkhider M, et al. TWEAK affects keratinocyte G2/M growth arrest and induces apoptosis through the translocation of the AIF protein to the nucleus. PLoS ONE. 2012;7:e33609 pubmed publisher
    ..Confocal microscopy showed that TWEAK induces the cleavage and the translocation of apoptosis inducing factor (AIF) from the mitochondria to the nucleus, thus initiating caspase-independent apoptosis...
  64. Ma J, Hu X, Li J, Wu D, Lan Q, Wang Q, et al. Enhancing conventional chemotherapy drug cisplatin-induced anti-tumor effects on human gastric cancer cells both in vitro and in vivo by Thymoquinone targeting PTEN gene. Oncotarget. 2017;8:85926-85939 pubmed publisher
    ..in p-AKT, CyclinD1, P-glycoprotein (P-gp), meanwhile, TQ and cisplatin also led to an increase in Bax, Cyt C, AIF, cleaved caspase 9, and cleaved caspase 3, and a decrease in Bcl-2, procaspase-9, procaspase-3...
  65. Dai Q, Yin Q, Zhao Y, Guo R, Li Z, Ma S, et al. III-10, a newly synthesized flavonoid, induces cell apoptosis with the involvement of reactive oxygen species-mitochondria pathway in human hepatocellular carcinoma cells. Eur J Pharmacol. 2015;764:353-62 pubmed publisher
    ..Our data also showed that III-10 induced the release of cytochrome c and AIF to cytosol followed after the reactive oxygen species accumulation...
  66. Kaszuba Zwoińska J, Ćwiklińska M, Balwierz W, Chorobik P, Nowak B, Wójcik Piotrowicz K, et al. Changes in cell death of peripheral blood lymphocytes isolated from children with acute lymphoblastic leukemia upon stimulation with 7 Hz, 30 mT pulsed electromagnetic field. Cell Mol Biol Lett. 2015;20:130-42 pubmed publisher
    ..of apoptosis-related genes revealed changes in mRNA of some genes engaged in the intrinsic apoptotic pathway belonging to the Bcl-2 family and the pathway with apoptosis-inducing factor (AIF) abundance upon PEMF stimulation of PBMCs.
  67. Simonis F, Sbrizzi A, Beld E, Lagendijk J, Van den Berg C. Improving the arterial input function in dynamic contrast enhanced MRI by fitting the signal in the complex plane. Magn Reson Med. 2016;76:1236-45 pubmed publisher
    ..prerequisite for obtaining quantitative values from DCE-MRI is the determination of the arterial input function (AIF). However, it is very challenging to accurately estimate the AIF using MR...
  68. Anitha J, Pradeep A, Sivaprasad V. Upregulation of Atg5 and AIF gene expression in synchronization with programmed cellular death events in integumental epithelium of Bombyx mori induced by a dipteran parasitoid infection. Bull Entomol Res. 2014;104:794-800 pubmed publisher
    ..Two cell death-associated proteins, autophagy 5-like (Atg5L) and apoptosis-inducing factor (AIF), in addition to caspase, are identified from the infected integumental epithelium through mass spectrometric ..
  69. Shelar S, Kaminska K, Reddy S, Kumar D, Tan C, Yu V, et al. Thioredoxin-dependent regulation of AIF-mediated DNA damage. Free Radic Biol Med. 2015;87:125-36 pubmed publisher
    ..we report the identification of a novel interaction between cytosolic/nuclear Trx1 and apoptosis inducing factor (AIF), and the redox sensitivity and biological significance of the Trx-AIF interaction was characterized...
  70. Zhang B, Fan X, Wang Z, Zhu W, Li J. Alpinumisoflavone radiosensitizes esophageal squamous cell carcinoma through inducing apoptosis and cell cycle arrest. Biomed Pharmacother. 2017;95:199-206 pubmed publisher
    ..The following study investigates the potential radiosensitizing effect of alpinumisoflavone (AIF) and explores its underlying mechanisms in ESCC...
  71. Sancho P, Sánchez Monteagudo A, Collado A, Marco Marín C, Domínguez González C, Camacho A, et al. A newly distal hereditary motor neuropathy caused by a rare AIFM1 mutation. Neurogenetics. 2017;18:245-250 pubmed publisher
    ..F210S) mutation was identified in the X-linked AIFM1 gene, which encodes for the apoptosis-inducing factor (AIF). The mutation was predicted as deleterious, according to in silico analysis...
  72. Yu W, Mechawar N, Krantic S, Quirion R. Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer disease. Am J Pathol. 2010;176:2209-18 pubmed publisher
    ..The apoptosis-inducing factor (AIF) is a mitochondrial oxido-reductase originally characterized as a mediator of caspase-independent programmed cell ..
  73. Farrand L, Kim J, Byun S, Im aram A, Lee J, Suh J, et al. The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis-inducing factor and X-linked inhibitor of apoptosis. J Biol Chem. 2014;289:1723-31 pubmed publisher
    ..Our findings provide rationale for further investigation of the effects of hirsutenone on chemoresistant OVCA in clinical studies. ..
  74. Cho S, Lee J, Ju M, Jeong E, Kim H, Lim J, et al. Cystamine induces AIF-mediated apoptosis through glutathione depletion. Biochim Biophys Acta. 2015;1853:619-31 pubmed publisher
    ..Here, we report a new pathway in which cystamine induces apoptosis by targeting apoptosis-inducing factor (AIF)...
  75. Park N, Baek H, Chun Y. Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling. PLoS ONE. 2015;10:e0134760 pubmed publisher
    ..induced voltage-dependent anion channel (VDAC) 1 expression and oligomerization, which may promote cytochrome c and AIF release...
  76. Zan J, Liu J, Zhou J, Wang H, Mo K, Yan Y, et al. Rabies virus matrix protein induces apoptosis by targeting mitochondria. Exp Cell Res. 2016;347:83-94 pubmed publisher
    ..through mitochondrial pathway by dissipating mitochondrial membrane potential, release of cytochrome c and AIF. CVS blocks Bax activation at the early stages of infection; while M protein partially targets mitochondria and ..
  77. Zhao Y, Lee J, Chen D, Gu X, Caslin A, Li J, et al. DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice. Neurochem Int. 2017;111:82-92 pubmed publisher
    ..events including caspase-3/9 activation, cytochrome c release from the mitochondria, and apoptosis-inducing factor (AIF) translocation into the nucleus in the pericontusion region were attenuated in NBP-treated mice compared to TBI-..
  78. Kalinowska M, Garncarz W, Pietrowska M, Garrard W, Widlak P. Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP. Apoptosis. 2005;10:821-30 pubmed
    ..We demonstrate that EndoG forms complexes with AIF and FEN-1 but not with PCNA...
  79. Santos S, Silva A, Matos M, Monteiro S, Alvaro A. Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53. Comp Biochem Physiol C Toxicol Pharmacol. 2016;185-186:138-146 pubmed publisher
    ..considering the different apoptosis pathways, the expression of caspases 3, 8 and 9, apoptosis inducing factor (AIF) and p53 genes was analyzed by quantitative real time PCR...
  80. Zhang W, Zhang C, Narayani N, Du C, Balaji K. Nuclear translocation of apoptosis inducing factor is associated with cisplatin induced apoptosis in LNCaP prostate cancer cells. Cancer Lett. 2007;255:127-34 pubmed
    ..In order to identify novel causes of resistance to cisplatin, we explored the role of Apoptosis Inducing Factor (AIF) that mediates caspase independent apoptosis in cisplatin induced cell death in PC...
  81. McKeller M, Herrera Rodriguez S, Ma W, Ortiz Quintero B, Rangel R, Cande C, et al. Vital function of PRELI and essential requirement of its LEA motif. Cell Death Dis. 2010;1:e21 pubmed publisher
    ..These findings may help to understand how bioenergetics is mechanistically connected with cell survival cues. ..
  82. Li S, Wan M, Cao X, Ren Y. Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma. Arch Pathol Lab Med. 2011;135:903-8 pubmed publisher
    ..inhibitor of apoptosis protein binding protein with low p I (Smac/DIABLO), apoptosis-inducing factor (AIF), and high temperature requirement protein A2 (HtrA2/Omi)...
  83. Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia G, et al. Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis. Mol Cell. 2015;58:1001-14 pubmed publisher
    Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic function, is required for the normal expression of major respiratory chain complexes...
  84. Ye F, Li X, Li F, Li J, Chang W, Yuan J, et al. Cyclosporin A protects against Lead neurotoxicity through inhibiting mitochondrial permeability transition pore opening in nerve cells. Neurotoxicology. 2016;57:203-213 pubmed publisher
    ..membrane potential (MMP) collapse, as well as the release of cytochrome C (Cyto C) and apoptosis-inducing factor (AIF) from mitochondria. These beneficial effects could finally result in cell survival under Pb-exposure conditions...
  85. Li Q, Bai Z, Zhao L, Li J. Characterization of allograft inflammatory factor-1 in Hyriopsis cumingii and its expression in response to immune challenge and pearl sac formation. Fish Shellfish Immunol. 2016;59:241-249 pubmed publisher
    The allograft inflammatory factor-1 (AIF-1) is one of the key factors associated with inflammatory response and immune defense...
  86. Sengupta D, Chowdhury K, Chatterjee S, Sarkar A, Paul S, Sur P, et al. Modulation of adenylate cyclase signaling in association with MKK3/6 stabilization under combination of SAC and berberine to reduce HepG2 cell survivability. Apoptosis. 2017;22:1362-1379 pubmed publisher
    ..Resultant tBid associated lysosomal protease mediated AIF truncation induced DNA fragmentation and persuaded effector caspase mediated scramblase activation resulting ..
  87. Mukhopadhyay R, Kazi J, Debnath M. Synthesis and characterization of copper nanoparticles stabilized with Quisqualis indica extract: Evaluation of its cytotoxicity and apoptosis in B16F10 melanoma cells. Biomed Pharmacother. 2018;97:1373-1385 pubmed publisher
    ..Gene transcript analysis showed up-regulation of caspase-dependent as well as caspase-independent (AIF) apoptotic genes in treated cells...
  88. Hu W, Dong H, Li Y, Ojcius D, Li S, Yan J. Bid-Induced Release of AIF/EndoG from Mitochondria Causes Apoptosis of Macrophages during Infection with Leptospira interrogans. Front Cell Infect Microbiol. 2017;7:471 pubmed publisher
    ..Although, the release of mitochondrial apoptosis-inducing factor (AIF) and endonuclease G (EndoG) in leptospire-infected macrophages has been described, the mechanisms linking caspase ..
  89. Stambolsky P, Weisz L, Shats I, Klein Y, Goldfinger N, Oren M, et al. Regulation of AIF expression by p53. Cell Death Differ. 2006;13:2140-9 pubmed
    ..b>AIF is a mitochondrial protein, which, upon translocation to the nucleus, can participate in apoptosis, primarily in a ..
  90. Yu G, Choi I, Kim G, Hwang H, Kim B, Kim C, et al. Induction of reactive oxygen species-mediated apoptosis by purified Schisandrae semen essential oil in human leukemia U937 cells through activation of the caspase cascades and nuclear relocation of mitochondrial apoptogenic factors. Nutr Res. 2015;35:910-20 pubmed publisher
    ..Based on our data, the consumption of Schisandrae semen or its essential oil is a good natural therapeutic agent for anticancer activity and regression. ..
  91. Tao T, Li C, Yang W, Zeng X, Song C, Yue Z, et al. Protective effects of propofol against whole cerebral ischemia/reperfusion injury in rats through the inhibition of the apoptosis-inducing factor pathway. Brain Res. 2016;1644:9-14 pubmed publisher
    ..Now, a new mitochondrial protein, apoptosis-inducing factor (AIF), has been shown to have relationship with the caspase-independent apoptotic pathway...
  92. Baets J, De Jonghe P, Timmerman V. Recent advances in Charcot-Marie-Tooth disease. Curr Opin Neurol. 2014;27:532-40 pubmed publisher
    ..This is a major challenge for geneticists and neurologists. No effective therapy is available for Charcot-Marie-Tooth. Several large trials with ascorbic acid were negative but research into novel compounds continues. ..