AHSA1

Summary

Gene Symbol: AHSA1
Description: activator of HSP90 ATPase activity 1
Alias: AHA1, C14orf3, hAha1, p38, activator of 90 kDa heat shock protein ATPase homolog 1, AHA1, activator of heat shock 90kDa protein ATPase homolog 1
Species: human
Products:     AHSA1

Top Publications

  1. Lotz G, Lin H, Harst A, Obermann W. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. J Biol Chem. 2003;278:17228-35 pubmed
    ..We have identified Aha1 (activator of Hsp90 ATPase) and its relative Hch1 (high copy Hsp90 suppressor) as binding partners of Hsp90 in ..
  2. Sun F, Mi Z, Condliffe S, Bertrand C, Gong X, Lu X, et al. Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J. 2008;22:3255-63 pubmed publisher
    ..and Hsp90 associated equally with WT and DeltaF508 CFTR, whereas nearly twice as much of the Hsp90 cochaperone, Aha1, associated with DeltaF508 CFTR...
  3. Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan J, Singh S, et al. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol Cell. 2002;10:1307-18 pubmed
    ..A ubiquitous family of stress-regulated proteins have been identified (Aha1, activator of Hsp90 ATPase) that bind directly to Hsp90 and are required for the in vivo Hsp90-dependent activation ..
  4. Wang X, Venable J, LaPointe P, Hutt D, Koulov A, Coppinger J, et al. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell. 2006;127:803-15 pubmed
    ..to the ER, DeltaF508, can be initiated by partial siRNA silencing of the Hsp90 cochaperone ATPase regulator Aha1. We propose that failure of DeltaF508 to achieve an energetically favorable fold in response to the steady-state ..
  5. Xu W, Mollapour M, Prodromou C, Wang S, Scroggins B, Palchick Z, et al. Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Mol Cell. 2012;47:434-43 pubmed publisher
    ..through the chaperone cycle requires release of p50(Cdc37) and recruitment of the ATPase activating cochaperone AHA1, but the molecular regulation of this complex process at the cellular level is poorly understood...
  6. Xu H, Jiang W, Feng L, Liu Y, Wu P, Jiang J, et al. Dietary vitamin C deficiency depresses the growth, head kidney and spleen immunity and structural integrity by regulating NF-κB, TOR, Nrf2, apoptosis and MLCK signaling in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;52:111-38 pubmed publisher
    ..05), and up-regulated Claudin-12, 15a, -15b, Fas ligand, mitogen-activated protein kinase kinase 6, p38 mitogen-activated protein kinase, B-cell lymphoma protein 2 associated X protein, apoptotic protease activating ..
  7. Xu H, Jiang W, Feng L, Liu Y, Wu P, Jiang J, et al. Dietary vitamin C deficiency depressed the gill physical barriers and immune barriers referring to Nrf2, apoptosis, MLCK, NF-?B and TOR signaling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare. Fish Shellfish Immunol. 2016;58:177-192 pubmed publisher
    ..3) up-regulated pore-forming TJs Claudin-12, 15a, -15b, and related signaling molecules myosin light chain kinase, p38 mitogen-activated protein kinase (rather than c-Jun N-terminal kinases) mRNA levels (P < 0...
  8. Cui X, Qian D, Jiang S, Shang E, Zhu Z, Duan J. Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway. Int J Mol Sci. 2018;19: pubmed publisher
    ..in T2DM rats showed that the MAPK pathway might account for the phenomenon with down-regulation of MAPK (P38 mitogen-activated protein kinases (P38), extracellular regulated protein kinases (ERK), and c-Jun N-terminal kinase ..
  9. Engin A. Human Protein Kinases and Obesity. Adv Exp Med Biol. 2017;960:111-134 pubmed publisher
    ..Additionally, obesity-activated calcium/calmodulin dependent-protein kinase II/p38 suppresses insulin-induced protein kinase B phosphorylation by activating the ER stress effector, activating ..

More Information

Publications148 found, 100 shown here

  1. Li C, Li L, Yang C, Zhong Y, Wu D, Shi L, et al. Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway. Biochem Biophys Res Commun. 2017;493:277-285 pubmed publisher
    ..extracellular regulated protein kinases(ERK),phosphorylated c-Jun N-terminal kinase (JNK), and phosphorylated p38 mitogen-activated protein kinase (MAPK) using real-time polymerase chain reaction (PCR) and Western blotting...
  2. Li S, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Deficiency of dietary niacin impaired gill immunity and antioxidant capacity, and changes its tight junction proteins via regulating NF-?B, TOR, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;55:212-22 pubmed publisher
    ..p65, I?B kinase ?, I?B kinase ?, I?B kinase ?, Kelch-like-ECH-associated protein 1b, myosin light chain kinase and p38 mitogen-activated protein kinase (p38 MAPK) were significantly increased (P < 0...
  3. Zhong W, Qian K, Xiong J, Ma K, Wang A, Zou Y. Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-?B related signaling. Biomed Pharmacother. 2016;83:302-313 pubmed publisher
    ..GSH-px) levels, and inhibited activation of the mitogen-activated protein kinases/c-Jun NH2-terminal kinase (P38/JNK) cascade in the livers of LPS-induced rats...
  4. Zhao X, Sun P, Li G, Yi R, Qian Y, Park K. Polyphenols in Kuding tea help prevent HCl/ethanol-induced gastric injury in mice. Food Funct. 2018;9:1713-1725 pubmed publisher
    ..protein in gastric tissue was stronger in the HKTP-treated mice than in the control mice, while the expression of p38 mitogen-activated protein kinase (P38MAPK, or p38), nuclear factor ?-light-chain-enhancer of activated B cells (NF-?..
  5. Mao Z, Shen S, Wan Y, Sun W, Chen H, Huang M, et al. Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid. J Ethnopharmacol. 2015;173:256-65 pubmed publisher
    ..biochemical parameters, renal histological changes and OS indicators, as well as the key protein expressions in p38 mitogen-activated protein kinase (p38MAPK)/serine-threonine kinase (Akt) signaling pathways and downstream ..
  6. Pan F, Feng L, Jiang W, Jiang J, Wu P, Kuang S, et al. Methionine hydroxy analogue enhanced fish immunity via modulation of NF-?B, TOR, MLCK, MAPKs and Nrf2 signaling in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;56:208-228 pubmed publisher
    ..mRNA levels, which might be attributed to the down-regulation of nuclear factor ?B p65, c-Rel, I?B kinase ?, p38 mitogen activated protein kinase, eIF4E-binding protein1 (4E-BP1) and 4E-BP2 mRNA levels and up-regulation of ..
  7. Guo Y, Jiang W, Wu P, Liu Y, Zhou X, Kuang S, et al. The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-?B, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngod. Fish Shellfish Immunol. 2017;65:145-168 pubmed publisher
    ..7, -8, -9, apoptotic protease activating factor-1 (Apaf-1), Bcl-2 associated X protein (Bax), Fas ligand (FasL), p38 mitogen-activated protein kinase (p38MAPK), Kelch-like ECH-associating protein (Keap) 1a, Keap1b, claudin-12 and ..
  8. Yun S, Han Y, Lee J, Kim S, Lee S. Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. Anticancer Res. 2017;37:2975-2984 pubmed
    ..activating transcription factor 4 (ATF4), phosphorylated inositol-requiring enzyme 1 alpha (IRE1?), phosphorylated p38, and C/EBP homologous protein (CHOP)...
  9. Xie W, Zhou P, Sun Y, Meng X, Dai Z, Sun G, et al. Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies. Cells. 2018;7: pubmed publisher
    ..and associated apoptosis via the Akt, Nrf2/HO-1, PPARγ/HO-1, extracellular regulated protein kinases (ERK), p38, and c-Jun N-terminal kinase (JNK) pathways (or mitochondrial apoptosis pathway) and the caspase-3/ROCK1/MLC ..
  10. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..the altered miRNAs, CI increased miR-34 in the serum and ileum which targeted an increased phosphorylation of ERK, p38, and increased NF-?B, thereby leading to increased iNOS expression and activation of caspase-3 in the ileum...
  11. Li L, Feng L, Jiang W, Jiang J, Wu P, Zhao J, et al. Dietary pantothenic acid depressed the gill immune and physical barrier function via NF-κB, TOR, Nrf2, p38MAPK and MLCK signaling pathways in grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;47:500-10 pubmed publisher
    ..IκB kinase α, IκB kinase β, IκB kinase γ, target of rapamycin and ribosomal S6 protein kinase1 p38 mitogen-activated protein kinases and myosin light-chain kinase mRNA levels (P<0.05)...
  12. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..MCP)-1, as well as phosphorylation of c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK), p38 mitogen-activated protein kinases (MAPK), and extracellular signal-regulated kinases 1/2 (ERK1/2)...
  13. Ahn S, Kim Y, Kim H, Choi Y, Lee J, Kim C, et al. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia. BMC Complement Altern Med. 2015;15:202 pubmed publisher
    ..Expression levels of phosphorylated p38 mitogen-activated protein kinases (MAPK) and dephosphorylated phosphatidylinositol-3 kinase (PI3K) by glutamate ..
  14. Shi L, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Folic acid deficiency impairs the gill health status associated with the NF-κB, MLCK and Nrf2 signaling pathways in the gills of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;47:289-301 pubmed publisher
    ..1 gene expression, whereas folic acid deficiency up-regulated claudin-12, claudin-15, myosin light chain kinase and p38 mitogen activated protein kinase gene expression in fish gills (P < 0.05)...
  15. Jemaà M, Fezai M, Bissinger R, Lang F. Methods Employed in Cytofluorometric Assessment of Eryptosis, the Suicidal Erythrocyte Death. Cell Physiol Biochem. 2017;43:431-444 pubmed publisher
    ..Signalling involved in the regulation of eryptosis includes Ca2+ entry, ceramide, caspases, calpain, p38 kinase, protein kinase C, Janus-activated kinase 3, casein kinase 1α, cyclin-dependent kinase 4, AMP-activated ..
  16. Lang E, Bissinger R, Qadri S, Lang F. Suicidal death of erythrocytes in cancer and its chemotherapy: A potential target in the treatment of tumor-associated anemia. Int J Cancer. 2017;141:1522-1528 pubmed publisher
    ..stimulating eryptosis includes increase of cytosolic Ca2+ -activity, ceramide, caspases, calpain, p38-kinase, protein-kinase C, Janus-activated kinase 3, casein-kinase 1α, and cyclin-dependent kinase 4...
  17. Luo L, Li J, Liu H, Jian X, Zou Q, Zhao Q, et al. Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts. Int J Mol Sci. 2017;18: pubmed publisher
    ..Moreover, adiponectin inhibited the phosphorylation of AMPK, p38 and extracellular-regulated kinase (ERK), but not that of Jun N-terminal kinase (JNK) or Akt, in CTGF-treated KFs...
  18. Feng L, Li S, Jiang W, Liu Y, Jiang J, Wu P, et al. Deficiency of dietary niacin impaired intestinal mucosal immune function via regulating intestinal NF-κB, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;49:177-93 pubmed publisher
    ..05), and increased Claudin 12, Kelch-like ECH-associating protein 1a (Keap1a), myosin light-chain kinase (MLCK) and p38 mitogen-activated protein kinase (p38 MAPK) mRNA expression levels in the intestine of young grass carp (P <Â..
  19. Kaur T, Borse V, Sheth S, Sheehan K, Ghosh S, Tupal S, et al. Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea. J Neurosci. 2016;36:3962-77 pubmed publisher
    ..phosphorylation of STAT1 Ser(727) (but not Tyr(701)) and STAT1 luciferase activity by suppressing the ERK1/2, p38, and JNK mitogen-activated protein kinase (MAPK) pathways...
  20. Seo B, Ryu H, Park Y, Huh J, Baek Y. Dual effect of WIN-34B on osteogenesis and osteoclastogenesis in cytokine-induced mesenchymal stem cells and bone marrow cells. J Ethnopharmacol. 2016;193:227-236 pubmed publisher
    ..levels of nuclear factor-kappaB (NF-?B), inhibitory kappa B-? (I?B?), phospho-NF-?B, phospho-I?B?, ?-actin, p38 MAPK, phospho-c-Jun N-terminal kinase (JNK), phospho-extracellular-signal regulated kinase (ERK), phospho-p38 ..
  21. Aslani F, Schuppe H, Guazzone V, Bhushan S, Wahle E, Lochnit G, et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. Hum Reprod. 2015;30:417-31 pubmed publisher
    ..response element-binding protein (CREB) activation in SC and PTC, while TM responded to HMGB1 stimulation with p38 mitogen-activated protein kinase (MAPK) and p65 nuclear factor Kappa B (NF-ĸB) phosphorylation followed by ..
  22. Sato Y, Watanabe R, Uchiyama N, Ozawa N, Takahashi Y, Shirai R, et al. Inhibitory effects of vasostatin-1 against atherogenesis. Clin Sci (Lond). 2018;132:2493-2507 pubmed publisher
    ..angiotensin II (AngII)-induced migration and collagen-3 and fibronectin expression via decreasing ERK1/2 and p38 phosphorylation, but increased elastin expression and matrix metalloproteinase (MMP)-2 and MMP-9 activities via ..
  23. Feng L, Chen Y, Jiang W, Liu Y, Jiang J, Wu P, et al. Modulation of immune response, physical barrier and related signaling factors in the gills of juvenile grass carp (Ctenopharyngodon idella) fed supplemented diet with phospholipids. Fish Shellfish Immunol. 2016;48:79-93 pubmed publisher
    ..protein 1a (Keap1a) and Keap1b; (3) the transcription abundance of myosin light chain kinase (MLCK) and p38 mitogen-activated protein kinase (p38 MAPK) genes...
  24. Wu P, Pan F, Feng L, Jiang W, Jiang J, Kuang S, et al. Methionine hydroxy analogue supplementation modulates gill immunological and barrier health status of grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2018;74:637-648 pubmed publisher
    ..mRNA levels, which might be attributed to the down-regulation of nuclear factor ?B p65, c-Rel, I?B kinase ?, p38 mitogen activated protein kinase, eIF4E-binding protein1 (4E-BP1) and 4E-BP2 mRNA levels and up-regulation of ..
  25. Yang X, Gao X, Du B, Zhao F, Feng X, Zhang H, et al. Ilex asprella aqueous extracts exert in vivo anti-inflammatory effects by regulating the NF-κB, JAK2/STAT3, and MAPK signaling pathways. J Ethnopharmacol. 2018;225:234-243 pubmed publisher
    ..proteins p65, IκBα, Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), p38 mitogen-activated protein kinases (p38), extracellular regulated protein kinases (ERK1/2), and c-Jun N-terminal ..
  26. Wu K, Ho Y, Kuo Y, Huang S, Huang G, Chang Y. Hepatoprotective Effect of Ugonin M, A Helminthostachyszeylanica Constituent, on Acetaminophen-Induced Acute Liver Injury in Mice. Molecules. 2018;23: pubmed publisher
    ..IκB-α), extracellular regulated kinase (ERK), c-Jun-N-terminal (JNK), and p38 active phosphorylation...
  27. Wang L, Huang Q, Li Y, Huang Y, Xie J, Xu L, et al. Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats. Mol Med Rep. 2017;: pubmed publisher
    ..of silymarin, western blot analysis was performed to investigate the protein expression of phosphorylated (p)-p38 and p-c-Jun N-terminal kinase (JNK) of the TNF-? induced inflammatory response and apoptotic pathways...
  28. Ahad A, Ahsan H, Mujeeb M, Siddiqui W. Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells. Chem Biol Interact. 2015;240:292-303 pubmed publisher
    ..b>p38 mitogen activated protein kinase (p38 MAPK), a serine-threonine kinase, plays an important role in tissue ..
  29. Gao X, Zhang Z, Li Y, Shen P, Hu X, Cao Y, et al. Selenium Deficiency Facilitates Inflammation Following S. aureus Infection by Regulating TLR2-Related Pathways in the Mouse Mammary Gland. Biol Trace Elem Res. 2016;172:449-57 pubmed publisher
    ..nuclear factor-κB (NF-κB), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 was greatly increased. The results indicate that Se deficiency could intensify the inflammatory reaction in S...
  30. Yang G, Li S, Yuan L, Yang Y, Pan M. Effect of nobiletin on the MAPK/NF-κB signaling pathway in the synovial membrane of rats with arthritis induced by collagen. Food Funct. 2017;8:4668-4674 pubmed publisher
    ..The protein expression levels of phosphorylated p38, p-p65 and the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (IκBα) in ..
  31. Liu L, Song H, Duan H, Chai J, Yang J, Li X, et al. TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling. Sci Rep. 2016;6:30121 pubmed publisher
    ..It was found that MSCs could only down-regulate P38 and JNK signaling, but had no effect on ERK in peritoneal macrophages of severe burn rats...
  32. Li X, Zhang Z, Wang H. Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways. Biomed Pharmacother. 2017;93:130-145 pubmed publisher
    ..Transforming growth factor-β1 (TGF-β1)/SMADs and mitogen-activated protein kinases (MAPKs), including p38, extracellular signal regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), signalling pathways were highly ..
  33. Riemann A, Reime S, Thews O. Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo. Neoplasia. 2017;19:1033-1042 pubmed publisher
    ..Finally, the activation of ERK1/2 and p38 by acidosis/hypoxia and their impact on cytokine expression were studied...
  34. Jha H, Shukla S, Lu J, Aj M, Banerjee S, Robertson E. Dissecting the contribution of EBNA3C domains important for EBV-induced B-cell growth and proliferation. Oncotarget. 2015;6:30115-29 pubmed publisher
    ..type EBV infected PBMCs had differential expression patterns for the phosphorylation of MAP kinases specifically p38, JNK and ERK. Regulation of β-catenin also differed among wild type and EBNA3C deleted mutants...
  35. Wu H, Cheng X, Hu L, Takeshita K, Hu C, Du Q, et al. Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway. Arterioscler Thromb Vasc Biol. 2016;36:1549-57 pubmed publisher
    ..CatS deficiency decreased the phosphorylation levels of p38 mitogen-activated protein kinase, Akt, and HDAC6 and toll-like receptor 2 expression in ligated arteries...
  36. Mo Q, Zhang Y, Jin X, Gao Y, Wu Y, Hao X, et al. Geldanamycin, an inhibitor of Hsp90, increases paclitaxel-mediated toxicity in ovarian cancer cells through sustained activation of the p38/H2AX axis. Tumour Biol. 2016;37:14745-14755 pubmed
    ..In particular, phosphorylation of p38, which activates H2AX, was significantly decreased in A2780T cells compared to the parental A2780 cells...
  37. Hou X, Li T, Ren Z, Liu Y. Combination of 2-deoxy d-glucose and metformin for synergistic inhibition of non-small cell lung cancer: A reactive oxygen species and P-p38 mediated mechanism. Biomed Pharmacother. 2016;84:1575-1584 pubmed publisher
    ..ROS) level, and mitochondrial membrane potential alteration, as well as increased apoptosis, caspase-3 activity, P-p38 and P-AMP-activated protein kinase (AMPK) level...
  38. Nishiura H, Yamanegi K, Kawabe M, Kato Kogoe N, Yamada N, Nakasho K. The roles of ribosomal protein S19 C-terminus in a shortened neutrophil lifespan through delta lactoferrin. Immunobiology. 2015;220:1085-92 pubmed publisher
    ..The S-tagged C5a-induced agonistic effects on chemotaxis, cytoplasmic Ca(2+) influx and p38 mitogen-activated protein kinase phosphorylation were not changed by Lf knockdown and δLf overexpression in ..
  39. Liu Z, Zhang B, Wang X, Li Y, Xi R, Han F, et al. Hypertonicity contributes to seawater aspiration-induced lung injury: Role of hypoxia-inducible factor 1α. Exp Lung Res. 2015;41:301-15 pubmed publisher
    ..between hypertonicity and hypoxia, when they induced HIF-1α, was studied and the roles of ATM, PI3K, and p38 in the course of hypertonicity inducing HIF-1α were investigated...
  40. Jin X, Wang J, Xia Z, Shang C, Chao Q, Liu Y, et al. Anti-inflammatory and Anti-oxidative Activities of Paeonol and Its Metabolites Through Blocking MAPK/ERK/p38 Signaling Pathway. Inflammation. 2016;39:434-446 pubmed publisher
    ..investigations on the mechanism showed that paeonol, M3, and M11 blocked the phosphorylation of MAPK/ERK 1/2 and p38, whereas they showed no effect on the phosphorylation of JNK...
  41. Seok J, Jeong C, Petriello M, Seo H, Yoo H, Hong K, et al. Piperlongumine decreases cell proliferation and the expression of cell cycle-associated proteins by inhibiting Akt pathway in human lung cancer cells. Food Chem Toxicol. 2018;111:9-18 pubmed publisher
    ..Rb)) and intracellular signaling molecules (extracellular signal receptor-activated kinase 1/2 (ERK1/2), Akt, p38 and nuclear factor-κB (NF-κB)) were examined in cells following treatment of PL using Western blot analysis...
  42. Paunovic V, Kosic M, Djordjevic S, Zugić A, Djalinac N, Gašić U, et al. Marrubium vulgare ethanolic extract induces proliferation block, apoptosis, and cytoprotective autophagy in cancer cells in vitro. Cell Mol Biol (Noisy-le-grand). 2016;62:108-114 pubmed
    ..It arrested cell cycle in S+G2/M phase, which was associated with the activation of MAP kinase p38 and up-regulation of antiproliferative genes p53, p21 and p27...
  43. Yan F, Chen X, Zheng X. Protective effect of mulberry fruit anthocyanin on human hepatocyte cells (LO2) and Caenorhabditis elegans under hyperglycemic conditions. Food Res Int. 2017;102:213-224 pubmed publisher
    ..reduction as well as total superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity recovery and PMK-1/p38 expression promotion...
  44. Xu G, Zhang L, Ma A, Qian Y, Ding Q, Liu Y, et al. SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells. Oncotarget. 2015;6:33636-47 pubmed publisher
    ..We further show that JNK but not p38 MAPK activation is involved in the GADD45G-mediated SIP1 upregulation, and that JNK inhibition counteracts the ..
  45. Shi J, Wang L, Lu Y, Ji Y, Wang Y, Dong K, et al. Protective effects of seabuckthorn pulp and seed oils against radiation-induced acute intestinal injury. J Radiat Res. 2017;58:24-32 pubmed publisher
    ..extracellular-signal-regulated kinase and reduced the levels of phosphorylated c-Jun N-terminal kinase and p38. Palmitoleic acid (PLA) and alpha linolenic acid (ALA) are the predominant components of pulp oil and seed oil, ..
  46. Giacoppo S, Rajan T, Iori R, Rollin P, Bramanti P, Mazzon E. The α-cyclodextrin complex of the Moringa isothiocyanate suppresses lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells through Akt and p38 inhibition. Inflamm Res. 2017;66:487-503 pubmed publisher
    ..phosphorylation, translocation of the nuclear factor-κB (NF-κB), and also via the suppression of Akt and p38 phosphorylation...
  47. Wing S. Deubiquitinases in skeletal muscle atrophy. Int J Biochem Cell Biol. 2013;45:2130-5 pubmed publisher
    ..Its expression is increased in both systemic and disuse forms of atrophy and can be regulated through a p38 MAP kinase signaling pathway...
  48. Huang B, Cheng J, Wu C, Chen P, Tu P, Fu Y, et al. Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells. Vascul Pharmacol. 2017;90:27-35 pubmed publisher
    ..Further studies showed that CPT phosphorylated p38 MAPK Thr180/Tyr182 and dephosphorylated Tau Ser199/202...
  49. Wang S, Jin H, Tang Q, Fu J, Ren Z, Peng C, et al. The effect of ethephon on immune system in male offspring of mice. Environ Toxicol Pharmacol. 2017;49:119-123 pubmed publisher
    ..Delayed type hypersensitivity(DTH) was inhibited in all groups. The expression of protein Bcl11b and p-p38 in thymus of treatment groups were lower than control group...
  50. Huang Q, Mao X, Wu H, Liu H, Sun M, Wang X, et al. Cynandione A attenuates neuropathic pain through p38? MAPK-mediated spinal microglial expression of ?-endorphin. Brain Behav Immun. 2017;62:64-77 pubmed publisher
    ..A also non-selectively upregulated phosphorylation of mitogen-activated protein kinases (MAPKs), including p38, extracellular signal regulated kinase (ERK1/2), and extracellular signal regulated kinase (JNK) in primary ..
  51. Liu S, Xu P, Luo X, Hu J, Liu X. (7R,8S)-Dehydrodiconiferyl Alcohol Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia by Inhibiting MAPK Signaling. Neurochem Res. 2016;41:1570-7 pubmed publisher
    ..attenuated LPS-induced phosphorylation of c-Jun N-terminal kinase 1/2 (JNK), but not protein kinase B, p38, or extracellular signal-regulated kinase 1/2...
  52. Park G, Park S, Kim D, Kim Y, Yoon S, Hur D. Berberine induces mitochondrial apoptosis of EBV-transformed B cells through p53-mediated regulation of XAF1 and GADD45?. Int J Oncol. 2016;49:411-21 pubmed publisher
    ..Blocking phosphorylation of p38/JNK MAPK and treatment with PFT-?, a selective p53 inhibitor, effectively prevented apoptosis and the upregulation ..
  53. Xia J, Huang N, Huang H, Sun L, Dong S, Su J, et al. Voltage-gated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1-mediated upregulation of NHE1. Int J Cancer. 2016;139:2553-69 pubmed publisher
    ..Mechanistically, the suppression of Nav 1.7 decreased NF-?B p65 nuclear translocation via p38 activation, thus reducing MACC1 expression...
  54. Stujanna E, Murakoshi N, Tajiri K, Xu D, Kimura T, Qin R, et al. Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism. PLoS ONE. 2017;12:e0189330 pubmed publisher
    ..Mmp)9, and the protein expression levels of phosphorylated NF-?B p65, phosphorylated ERK, and phosphorylated p38 were also significantly lower in MI+SR than in MI+V...
  55. Xiong W, Shao Z, Xiong Y, Chen J, Sun Y, Zhu L, et al. Dehydroandrographolide enhances innate immunity of intestinal tract through up-regulation the expression of hBD-2. Daru. 2015;23:37 pubmed publisher
    ..By using SB203580 and SB202190 (inhibitors of p38), the enhancement of hBD-2 expression were significantly attenuated...
  56. Zheng M, Zang S, Xie L, Fang X, Zhang Y, Ma X, et al. Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer. Oncol Lett. 2015;10:1655-1661 pubmed
    ..It was previously reported that upon energy-stress stimulation, the phosphorylation of Rheb at serine 130 by p38-regulated/activated protein kinase (PRAK) results in the impaired nucleotide binding ability of Rheb and inhibits ..
  57. Oliveira L, Danilucci T, Chaves Neto A, Campanelli A, Silva T, Oliveira S. Tracheal Smooth Muscle Cells Stimulated by Stem Cell Factor-c-Kit Coordinate the Production of Transforming Growth Factor-β1 and Fibroblast Growth Factor-2 Mediated by Chemokine (C-C Motif) Ligand 3. J Interferon Cytokine Res. 2016;36:401-11 pubmed publisher
    ..Pretreatment with mitogen-activated protein kinase kinase 1, p38, and Jun N-terminal kinase inhibitors showed that the effects mediated by SCF were involved with the modulation of ..
  58. Subbaramaiah K, Brown K, Zahid H, Balmus G, Weiss R, Herbert B, et al. Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells. J Biol Chem. 2016;291:16011-23 pubmed publisher
    ..Inhibition of Hsp90 ATPase suppressed aromatase expression. Silencing Aha1 (activator of Hsp90 ATPase 1), a co-chaperone of Hsp90 required for its ATPase activity, led to both inhibition of ..
  59. Kuek V, Yang Z, Chim S, Zhu S, Xu H, Chow S, et al. NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase. Sci Rep. 2016;6:36210 pubmed publisher
    ..We show that NPNT stimulates the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated kinase (MAPK) in endothelial cells...
  60. Huang Y, Yang C, Li T, Zouboulis C, Hsu H. Cell-free extracts of Propionibacterium acnes stimulate cytokine production through activation of p38 MAPK and Toll-like receptor in SZ95 sebocytes. Life Sci. 2015;139:123-31 pubmed publisher
    ..The degradation of IκB-α and increased phosphorylation of IκB-α, p38 mitogen activated protein kinase (MAPK), CREB, and STAT3 were demonstrated...
  61. Chen F, Zhang J, He Y, Fang X, Wang Y, Chen M. Glycyrrhetinic acid-decorated and reduction-sensitive micelles to enhance the bioavailability and anti-hepatocellular carcinoma efficacy of tanshinone IIA. Biomater Sci. 2016;4:167-82 pubmed publisher
    ..ROS level, the increased cell cycle arrest at S phase, enhanced necrocytosis and up-regulation of caspase 3/7, P38 protein expression...
  62. Yun S, Woo S, Oh S, Hong S, Choe T, Ye S, et al. Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells. Mol Cell Endocrinol. 2016;422:64-73 pubmed publisher
    ..Combined treatment with melatonin and ATO induced the phosphorylation of JNK and p38 MAP kinase downstream from Redd1 expression...
  63. Li Y, Pan K, Chen L, Ning J, Li X, Yang T, et al. Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. J Neuroinflammation. 2016;13:268 pubmed
    ..Treatment with DFO significantly reduced neuroinflammation and improved cognitive decline by modulating p38 MAPK signaling, reactive oxygen species, and pro-inflammatory cytokines release...
  64. Yue Q, Feng L, Cao B, Liu M, Zhang D, Wu W, et al. Proteomic Analysis Revealed the Important Role of Vimentin in Human Cervical Carcinoma HeLa Cells Treated With Gambogic Acid. Mol Cell Proteomics. 2016;15:26-44 pubmed publisher
    ..The GA-activated signal transduction, from p38 MAPK, heat shock protein 27 (HSP27), vimentin, dysfunction of cytoskeleton, to cell death, was predicted and then ..
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    ..The expression of caspase-3, Bax, Bcl-2, ERK 1/2 and p38(MAPK) was evaluated by Western blotting and generation of intracellular ROS and changes in anion superoxide levels ..
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  67. Tateda S, Kanno H, Ozawa H, Sekiguchi A, Yahata K, Yamaya S, et al. Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury. J Orthop Res. 2017;35:93-103 pubmed publisher
    ..In addition, the activity of p38 MAPK in the lumbar spinal cord was significantly attenuated by rapamycin treatment...
  68. Nakanishi M, Nakae A, Kishida Y, Baba K, Sakashita N, Shibata M, et al. Go-sha-jinki-Gan (GJG) ameliorates allodynia in chronic constriction injury-model mice via suppression of TNF-? expression in the spinal cord. Mol Pain. 2016;12: pubmed publisher
    ..GJG decreased the phosphorylation of p38 in the ipsilateral dorsal horn...
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    ..Knockdown of MERTK, but not AXL or TYRO3 by shRNA in PCa cells induced a decreased ratio of P-Erk1/2 to P-p38, increased expression of p27, NR2F1, SOX2, and NANOG, induced higher levels of histone H3K9me3 and H3K27me3, and ..
  71. Yang Z, Wu B, Jia S, Zhao Y, Hou R, Liu X, et al. The mechanically activated p38/MMP-2 signaling pathway promotes bone marrow mesenchymal stem cell migration in rats. Arch Oral Biol. 2017;76:55-60 pubmed publisher
    ..to investigate the effect of static strain on bone marrow mesenchymal stem cell (BMMSC) migration and whether the p38/matrix metalloproteinase-2 (MMP-2) axis plays a role in induction of BMMSC migration under mechanical strain...
  72. Khan S, Malhotra R, Rani N, Sahu A, Tomar A, Garg S, et al. Febuxostat Modulates MAPK/NF-?Bp65/TNF-? Signaling in Cardiac Ischemia-Reperfusion Injury. Oxid Med Cell Longev. 2017;2017:8095825 pubmed publisher
    ..The MAPK-based molecular mechanism revealed suppression of active JNK and p38 proteins concomitant with the rise in ERK1/ERK2, a prosurvival kinase...
  73. Bernal Mizrachi E, Wen W, Srinivasan S, Klenk A, Cohen D, Permutt M. Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells. Am J Physiol Endocrinol Metab. 2001;281:E1286-99 pubmed
    ..Experiments with p38, phosphatidylinositol 3-kinase, and protein kinase A inhibitors indicated that these pathways are not involved...
  74. Maiorino M, Bellastella G, Giugliano D, Esposito K. Cooling down inflammation in type 2 diabetes: how strong is the evidence for cardiometabolic benefit?. Endocrine. 2017;55:360-365 pubmed publisher
    ..Until now, a large trial with losmapimod (a p38 inhibitor) among patients with acute myocardial infarction, including one/third of diabetic patients, showed no ..
  75. Porrini V, Sarnico I, Benarese M, Branca C, Mota M, Lanzillotta A, et al. Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation. Int J Mol Sci. 2017;18: pubmed publisher
    ..Additionally, CSP-1103 limited earlier activation of p38 and nuclear factor ?B (NF-?B) pathways...
  76. Kundumani Sridharan V, Subramani J, Das K. Thioredoxin Activates MKK4-NFκB Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells. J Biol Chem. 2015;290:17505-19 pubmed publisher
    ..kinase 4 (MKK4) is activated via phosphorylation of Ser-257 and Thr-261 by upstream MAP3Ks and activates JNK and p38 MAPKs in response to cellular stress...
  77. Pai C, Yen C, Chen C, Yu I, Lin S, Lin S. Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy. PLoS ONE. 2016;11:e0151617 pubmed publisher
    ..Moreover, increased expression of interleukin-1β and downstream phosphorylated-p38-mitogen-activated protein kinase were concordant with apoptosis induction in the placentas of salt water-treated ..
  78. Zhu S, Xu X, Wang L, Su L, Gu Q, Wei F, et al. Inhibitory effect of a novel peptide, H-RN, on keratitis induced by LPS or poly(I:C) in vitro and in vivo via suppressing NF-κB and MAPK activation. J Transl Med. 2017;15:20 pubmed publisher
    ..The translocation of NF-κB and phosphorylation of IκBα, NF-κB, p38, JNK, and ERK were significantly inhibited by H-RN. No sign of toxicity was observed...
  79. DeLeon Pennell K. May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for?. J Mol Cell Cardiol. 2016;91:201-3 pubmed publisher
    ..present evidence for the first time that Ang II induces cardiac fibrosis by enhancing DDR2 expression in cardiac fibroblasts via p38 mitogen activated protein kinase (p38 MAPK)-mediated activation of nuclear factor-κB (NF-κB).
  80. Dunoyer Geindre S, Rivier Cordey A, Tsopra O, Lecompte T, Kruithof E. Effect of ATRA and ATO on the expression of tissue factor in NB4 acute promyelocytic leukemia cells and regulatory function of the inflammatory cytokines TNF and IL-1?. Ann Hematol. 2017;96:905-917 pubmed publisher
    ..Inhibition of the inflammatory signaling intermediate p38 reduced TF mRNA by one third but increased TNF and IL-1? mRNA...
  81. Patel S, D Lugos A, Eldon E, Curtis D, Dickinson J, Carroll C. Impact of acetaminophen consumption and resistance exercise on extracellular matrix gene expression in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2017;313:R44-R50 pubmed publisher
    ..MMP-2 and TIMP-1 protein was not altered by RE or APAP (P > 0.05). Phosphorylation of ERK1/2 and p38-MAPK increased (P < 0.05) with RE but was not influenced by APAP...
  82. Moriwaki K, Asahi M. Augmented TME O-GlcNAcylation Promotes Tumor Proliferation through the Inhibition of p38 MAPK. Mol Cancer Res. 2017;15:1287-1298 pubmed publisher
    ..The tumors grown in Ogt-Tg/+ mice showed significant downregulation of p38 MAPK activity and upregulation of the ERK1/2 signaling pathway...
  83. Saha B, Patro B, Koli M, Pai G, Ray J, Bandyopadhyay S, et al. trans-4,4'-Dihydroxystilbene (DHS) inhibits human neuroblastoma tumor growth and induces mitochondrial and lysosomal damages in neuroblastoma cell lines. Oncotarget. 2017;8:73905-73924 pubmed publisher
    ..The ROS, produced by DHS activated the p38 and JNK MAPKs to augment the BAX activity and BID-cleavage, and induce LMP and MMP in the cells...
  84. Qi S, Kou X, Lv J, Qi Z, Yan L. Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK. Environ Toxicol Pharmacol. 2015;40:847-54 pubmed publisher
    ..In addition, ampelopsin activated ERK1/2 and P38, but little JNK1/2 activation was detected...
  85. Lin Y, Lin Y, Huang M, Kuo P, Wu C, Lee M, et al. Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification. Mol Immunol. 2017;83:82-91 pubmed publisher
    ..Etanercept and adalimumab suppressed mitogen-activated protein kinase (MAPK) phospho-p38, phospho-JNK, phospho-ERK and nuclear factor-κB (NF-κB) phospho-p65, as demonstrated using western blot ..
  86. Tohme S, Yazdani H, Liu Y, Loughran P, van der Windt D, Huang H, et al. Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction. Hepatology. 2017;66:182-197 pubmed publisher
    ..This binding leads to activation of p38 and subsequent phosphorylation of PGC-1?, with resultant up-regulation of mitochondrial biogenesis.
  87. Dong X, Jia Y, Ge L, Jiang B, Jiang J, Shen J, et al. Soluble epoxide hydrolase inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways. Toxicology. 2017;389:31-41 pubmed publisher
    ..Additionally, AUDA regulated the expression of ?-smooth muscle actin (?-SMA) and E-cadherin by inhibiting the Smad3/p38 signaling pathway...
  88. Kehlen A, Haegele M, Böhme L, Cynis H, Hoffmann T, Demuth H. N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity. Biosci Rep. 2017;37: pubmed publisher
    ..stronger effect on phosphorylation of ERK (extracellular signal regulated kinase) 1/2, Akt (protein kinase B), and p38 (p38 mitogen-activated protein kinase) kinases than the immature Gln1-CX3CL1 in a time- and concentration-dependent ..
  89. Kasai S, Richardson M, Torii S, Yasumoto K, Shima H, Igarashi K, et al. Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2. FEBS J. 2017;284:4115-4127 pubmed publisher
    ..Increase in IPAS-induced mitochondrial clustering by UVB was completly inhibited by the p38 MAPK inhibitor SB203580...
  90. Chu Y, Chen S, Hsieh Y, Teng Y, Cheng Y. Low-level laser therapy prevents endothelial cells from TNF-?/cycloheximide-induced apoptosis. Lasers Med Sci. 2018;33:279-286 pubmed publisher
    ..In addition, LLLT increased ERK MAPK phosphorylation and suppressed the TNF/CHX-increased p38 MAPK, JNK, IKK phosphorylation, NF-?B translocation, and iNOS expression...
  91. Bistrović A, Harej A, Grbčić P, Sedic M, Kraljevic Pavelic S, Cetina M, et al. Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases. Int J Mol Sci. 2017;18: pubmed publisher
    ..concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma) and p38 MAP (mitogen-activated protein) kinases...
  92. Song S, Bae C, Choi Y, Kim Y. Cadmium induces mucin 8 expression via Toll-like receptor 4-mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells. Int Forum Allergy Rhinol. 2016;6:638-45 pubmed publisher
    ..phosphorylation of extracellular signal related kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) and p38 MAPK...