Gene Symbol: AHNAK
Description: AHNAK nucleoprotein
Alias: AHNAKRS, PM227, neuroblast differentiation-associated protein AHNAK, AHNAK-related, desmoyokin
Species: human
Products:     AHNAK

Top Publications

  1. Gentil B, Delphin C, Mbele G, Deloulme J, Ferro M, Garin J, et al. The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B. J Biol Chem. 2001;276:23253-61 pubmed
    ..In an attempt to define the molecular basis of the S100B action, we have identified the giant phosphoprotein AHNAK as the major and most specific Ca(2+)-dependent S100B target protein in rat embryo fibroblast cells...
  2. Kudoh J, Wang Y, Minoshima S, Hashimoto T, Amagai M, Nishikawa T, et al. Localization of the human AHNAK/desmoyokin gene (AHNAK) to chromosome band 11q12 by somatic cell hybrid analysis and fluorescence in situ hybridization. Cytogenet Cell Genet. 1995;70:218-20 pubmed
    Using a panel of somatic cell hybrids, we have mapped the locus for the AHNAK/desmoyokin gene (AHNAK) to human chromosome 11...
  3. Shtivelman E, Cohen F, Bishop J. A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure. Proc Natl Acad Sci U S A. 1992;89:5472-6 pubmed
    We report here the identification and partial characterization of a human gene (designated AHNAK) that encodes an unusually large protein (approximately 700 kDa). AHNAK is expressed by means of a 17...
  4. Sussman J, Stokoe D, Ossina N, Shtivelman E. Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. J Cell Biol. 2001;154:1019-30 pubmed
    b>AHNAK is a ubiquitously expressed giant phosphoprotein that was initially identified as a gene product subject to transcriptional repression in neuroblastoma...
  5. Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H. The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton. FASEB J. 2002;16:1205-16 pubmed
    b>Ahnak is a ubiquitously expressed giant protein of 5643 amino acids implicated in cell differentiation and signal transduction...
  6. Benaud C, Gentil B, Assard N, Court M, Garin J, Delphin C, et al. AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. J Cell Biol. 2004;164:133-44 pubmed
    ..In Madin-Darby canine kidney cells, the protein AHNAK relocates from the cytosol to the cytosolic surface of the plasma membrane during the formation of cell-cell ..
  7. Huang Y, de Morrée A, van Remoortere A, Bushby K, Frants R, den Dunnen J, et al. Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle. Hum Mol Genet. 2008;17:1855-66 pubmed publisher
    ..The coexistence of CAPN3 and AHNAK, a protein involved in subsarcolemmal cytoarchitecture and membrane repair, in the dysferlin protein complex and ..
  8. Haase H, Pagel I, Khalina Y, Zacharzowsky U, Person V, Lutsch G, et al. The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction. FASEB J. 2004;18:839-41 pubmed
    b>Ahnak, a 700 kDa protein, is expressed in a variety of cells and has been implicated in different cell-type-specific functions...
  9. Huang Y, Laval S, van Remoortere A, Baudier J, Benaud C, Anderson L, et al. AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration. FASEB J. 2007;21:732-42 pubmed
    ..By coimmunoprecipitation coupled with mass spectrometry, we demonstrate that AHNAK interacts with dysferlin...

More Information


  1. Haase H, Alvarez J, Petzhold D, Doller A, Behlke J, Erdmann J, et al. Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation. FASEB J. 2005;19:1969-77 pubmed
    ..2)- and beta2-channel subunits and ahnak, an associated 5643-amino acid (aa) protein...
  2. Han H, Kursula P. Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping. J Biol Chem. 2014;289:14121-31 pubmed publisher
    ..We present the crystal structures of the PDZ-like domains from PRX and its homologue AHNAK nucleoprotein 2 (AHNAK2)...
  3. Jin J, Bhatti D, Lee K, Medrihan L, Cheng J, Wei J, et al. Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. Mol Psychiatry. 2019;: pubmed publisher
    ..Here we report that Ahnak, whose function in the brain has been obscure, stabilizes p11 and Anxa2 proteins in the hippocampus and prefrontal ..
  4. Suzuki S, Fukuda T, Nagayasu S, Nakanishi J, Yoshida K, Hirata Tsuchiya S, et al. Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles. Sci Rep. 2019;9:3825 pubmed publisher
    ..Furthermore, giant molecule AHNAK and PKR were detected in microvesicles derived from dental pulp cells, and gene silencing of AHNAK in dental pulp ..
  5. Peng R, Zhang P, Yang X, Wei C, Huang X, Cai J, et al. Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38:113 pubmed publisher
    ..factor-β (TGF-β) signaling via ubiquitinating and degrading neuroblast differentiation-associated protein (AHNAK), a well-established inhibitor of TGF-β signaling...
  6. Han M, Han K, Kim A, Kang W, Kang Y, Kang J, et al. Whole-exome sequencing identifies variants associated with structural MRI markers in patients with bipolar disorders. J Affect Disord. 2019;249:159-168 pubmed publisher
    ..We identified 122 BD-related genes including KMT2C, AHNAK, CDH23, DCHS1, FRAS1, MACF1 and RYR3 and observed 27 recurrent copy number alteration regions including gain on ..
  7. Gu J, Mao W, Ren W, Xu F, Zhu Q, Lu C, et al. Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex. Cancer Lett. 2018;443:125-134 pubmed publisher
    ..Knockdown of UBE3C reduced NSCLC stemness and tumorigenesis both in vivo and in vitro. We further identified AHNAK as a novel UBE3C substrate, finding that UBE3C maintained stemness by ubiquitinating and promoting AHNAK ..
  8. Shen N, Chen N, Zhou X, Zhao B, Huang R, Liang J, et al. Alterations of the gut microbiome and plasma proteome in Chinese patients with adolescent idiopathic scoliosis. Bone. 2019;120:364-370 pubmed publisher
    ..AIS were Fibronectin 1 (FN1), voltage-dependent anion channel 1 (VDAC1), Ras homolog family member A (RHOA), and AHNAK nucleoprotein (AHNAK)...
  9. Sohn M, Shin S, Yoo J, Goh Y, Lee I, Bae Y. Ahnak promotes tumor metastasis through transforming growth factor-β-mediated epithelial-mesenchymal transition. Sci Rep. 2018;8:14379 pubmed publisher
    Previously, we reported a molecular mechanism by which Ahnak potentiates transforming growth factor-β (TGFβ) signaling during cell growth. Here, we show that Ahnak induces epithelial-mesenchymal transition (EMT) in response to TGFβ...
  10. Awasthi S, Maity T, Oyler B, Qi Y, Zhang X, Goodlett D, et al. Quantitative targeted proteomic analysis of potential markers of tyrosine kinase inhibitor (TKI) sensitivity in EGFR mutated lung adenocarcinoma. J Proteomics. 2018;189:48-59 pubmed publisher
    ..monitoring (immuno-MRM)-based quantitation assays for select phosphosites including EGFR-pY1197, pY1172, pY998, AHNAK-pY160, pY715, DAPP1-pY139, CAV1-pY14, INPPL1-pY1135, NEDD9-pY164, NF1-pY2579, and STAT5A-pY694...
  11. Yao J, Ong S, Bajjalieh S. Huntingtin is associated with cytomatrix proteins at the presynaptic terminal. Mol Cell Neurosci. 2014;63:96-100 pubmed
    ..The presynaptic cytomatrix proteins Bassoon, Piccolo/Aczonin and Ahnak were among the most consistently identified binding partners...
  12. Davis T, Loos B, Engelbrecht A. AHNAK: the giant jack of all trades. Cell Signal. 2014;26:2683-93 pubmed publisher
    The nucleoprotein AHNAK is an unusual and somewhat mysterious scaffolding protein characterised by its large size of approximately 700 kDa...
  13. Boonanuntanasarn S, Nakharuthai C, Schrama D, Duangkaew R, Rodrigues P. Effects of dietary lipid sources on hepatic nutritive contents, fatty acid composition and proteome of Nile tilapia (Oreochromis niloticus). J Proteomics. 2019;192:208-222 pubmed publisher
    ..Dietary LO increased the abundant levels of cytoskeleton-related proteins (i.e., ACTB, AHNAK, ERC2, KRT18, and RILP1). Other proteins (i.e...
  14. Woo J, Shin J, Lee S, Park H, Cho S, Sung Y, et al. Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1? expression. Cell Death Dis. 2018;9:864 pubmed publisher
    The role of Ahnak in obesity has been reported previously. Loss of Ahnak leads to decreased Bmp4/Smad1 signaling, resulting in the downregulation of adipocyte differentiation...
  15. Lee H, Kim K, Woo J, Park J, Kim H, Lee K, et al. Quantitative Proteomic Analysis Identifies AHNAK (Neuroblast Differentiation-associated Protein AHNAK) as a Novel Candidate Biomarker for Bladder Urothelial Carcinoma Diagnosis by Liquid-based Cytology. Mol Cell Proteomics. 2018;17:1788-1802 pubmed publisher
    ..comparative mRNA expression profiles from The Cancer Genome Atlas identified four putative candidate proteins, AHNAK, EPPK1, MYH14 and OLFM4...
  16. Park J, Kim I, Choi J, Lim H, Shin J, Kim Y, et al. AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development. Mol Cancer Res. 2018;16:1287-1298 pubmed publisher
    b>AHNAK is known to be a tumor suppressor in breast cancer due to its ability to activate the TGFβ signaling pathway. However, the role of AHNAK in lung tumor development and progression remains unknown...
  17. Cardinali B, Cappella M, Provenzano C, García Manteiga J, Lazarevic D, Cittaro D, et al. MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells. Cell Death Dis. 2016;7:e2086 pubmed publisher
    ..we have identified two new targets of microRNA-222 involved in the regulation of myogenic differentiation, Ahnak and Rbm24...
  18. Westcot S, Hatzold J, Urban M, Richetti S, Skuster K, Harm R, et al. Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS ONE. 2015;10:e0130688 pubmed publisher
    ..Eight genes--fras1, grip1, hmcn1, msxc, col4a4, ahnak, capn12, and nrg2a--had been described in an integumentary context to varying degrees, while arhgef25b, fkbp10b, ..
  19. Shin J, Kim Y, Kim I, Choi D, Yi S, Seong J. Increased Cell Proliferations and Neurogenesis in the Hippocampal Dentate Gyrus of Ahnak Deficient Mice. Neurochem Res. 2015;40:1457-62 pubmed publisher
    Expression of the giant protein Ahnak has been reported in endothelial cells of the blood brain barrier and in non-neuronal cells including myelinating Schwann cells. However, the function of Ahnak in neurogenesis has not been determined...
  20. Johnson S, Wheeler J, Thorpe R, Collins M, Takeuchi Y, Zhao Y. Mass spectrometry analysis reveals differences in the host cell protein species found in pseudotyped lentiviral vectors. Biologicals. 2018;52:59-66 pubmed publisher
    ..This may be due to the presence of co-purified VSV-G vesicles in transiently produced vectors. AHNAK (Desmoyokin) was unique to RDpro-Env vectors...
  21. Lu D, Wang J, Shi X, Yue B, Hao J. AHNAK2 is a potential prognostic biomarker in patients with PDAC. Oncotarget. 2017;8:31775-31784 pubmed publisher
    b>AHNAK nucleoprotein 2 (AHNAK2) belongs to the AHNAK protein family. The studies of AHNAK2 are limited...
  22. Shin J, Lee S, Kim Y, Kim I, Kim Y, Kyeong D, et al. AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to ?-adrenergic signalling. Sci Rep. 2016;6:23426 pubmed publisher
    ..The deficiency in the thermogenesis induced by neuroblast differentiation-associated protein AHNAK in white adipose tissue (WAT) of mice fed a high-fat diet suggests that AHNAK may stimulate energy expenditure via ..
  23. Davis T, van Niekerk G, Peres J, Prince S, Loos B, Engelbrecht A. Doxorubicin resistance in breast cancer: A novel role for the human protein AHNAK. Biochem Pharmacol. 2018;148:174-183 pubmed publisher
    ..The human AHNAK protein is a giant scaffold protein implicated in several diverse cellular functions...
  24. Shin J, Kim I, Kim Y, Shin S, Roh K, Lee S, et al. Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure. PLoS ONE. 2015;10:e0139720 pubmed publisher
    Recent evidence has suggested that AHNAK expression is altered in obesity, although its role in adipose tissue development remains unclear...
  25. Martín Ávila A, Medina Tamayo J, Ibarra Sanchez A, Vázquez Victorio G, Castillo Arellano J, Hernández Mondragón A, et al. Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKC?/? Signaling Node Leading to TNF Secretion. J Immunol. 2016;196:5075-88 pubmed publisher
    ..and increased its association with the adapter protein neuroblast differentiation-associated protein (AHNAK, desmoyokin). LPS-induced PKC?/? activity was associated with VAMP3 coalescence in WT and Fyn-deficient cells...
  26. Sundararaj S, Shishmarev D, Lin Y, Aditya S, Casarotto M. 1H, 13C and 15N backbone NMR chemical shift assignments of the C-terminal P4 domain of Ahnak. Biomol NMR Assign. 2018;12:253-257 pubmed publisher
    b>Ahnak is a ~ 700 kDa polypeptide that was originally identified as a tumour-related nuclear phosphoprotein, but later recognized to play a variety of diverse physiological roles related to cell architecture and migration...
  27. Olsen J, Cao X, Han B, Chen L, Horvath A, Richardson T, et al. Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics. Mol Cell Proteomics. 2016;15:892-905 pubmed publisher
    ..PDAP1-K126 as well as numerous sites within the repetitive units of two unique and exceptionally large proteins, AHNAK and AHNAK2...
  28. Sheets J, Iwanicki M, Liu J, Howitt B, Hirsch M, Gubbels J, et al. SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance. Oncogenesis. 2016;5:e264 pubmed publisher
    ..between SUSD2 and well-characterized mesenchymal proteins, including Twist-1, Zeb-1, N-cadherin, STEAP1, AHNAK, Snail-1, COL5A2 and Snail-3 in OVCAR3, OVSAHO and KURAMOCHI cell line models...
  29. Deniger D, Pasetto A, Tran E, Parkhurst M, Cohen C, Robbins P, et al. Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System. Mol Ther. 2016;24:1078-1089 pubmed publisher
    ..Patient-specific TCRs reactive against HLA-A*0201-restriced neoantigens AHNAK(S2580F) or ERBB2(H473Y) or the HLA-DQB*0601-restricted neoantigen ERBB2IP(E805G) were assembled with murine ..
  30. Zhang H, Yang L, Liu Z, Liu C, Teng X, Zhang L, et al. iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of potential biomarkers. Oncol Lett. 2017;14:3734-3740 pubmed publisher
    ..In addition, transgelin-2 and AHNAK nucleoprotein 2 were identified as potential novel biomarkers for the prognosis and treatment of PTC.
  31. James M, Richard C, Schott J, Yousry C, Clark K, Bell J, et al. A radiation hybrid map of 506 STS markers spanning human chromosome 11. Nat Genet. 1994;8:70-6 pubmed
    ..These markers and the map can be used for high resolution physical and genetic mapping. ..
  32. de Morrée A, Droog M, Grand Moursel L, Bisschop I, Impagliazzo A, Frants R, et al. Self-regulated alternative splicing at the AHNAK locus. FASEB J. 2012;26:93-103 pubmed publisher
    b>AHNAK is a 700-kDa protein involved in cytoarchitecture and calcium signaling. It is secondarily reduced in muscle of dysferlinopathy patients and accumulates in muscle of calpainopathy patients, both affected by a muscular dystrophy...
  33. Dempsey B, Rezvanpour A, Lee T, Barber K, Junop M, Shaw G. Structure of an asymmetric ternary protein complex provides insight for membrane interaction. Structure. 2012;20:1737-45 pubmed publisher
    ..Here, we present the three-dimensional structure of a multiprotein complex that includes S100A10, annexin A2, and AHNAK, which along with dysferlin, functions in muscle and cardiac tissue repair. The 3...
  34. Dumitru C, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S. AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma. PLoS ONE. 2013;8:e56420 pubmed publisher
    AHNAK/Desmoyokin is a giant protein which has been recently linked to reorganization of the actin cytoskeleton, cellular migration and invasion...
  35. Weiner O, Rentel M, Ott A, Brown G, Jedrychowski M, Yaffe M, et al. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006;4:e38 pubmed
  36. Pankonien I, Alvarez J, Doller A, Köhncke C, Rotte D, Regitz Zagrosek V, et al. Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity. J Muscle Res Cell Motil. 2011;32:281-90 pubmed publisher
    ..But, tuning ahnak1/Cav?(2) interaction provides a tool for modulating the beta-adrenergic response of I (CaL). ..
  37. Oh Y, Gao P, Lee K, Ceglia I, Seo J, Zhang X, et al. SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell. 2013;152:831-43 pubmed publisher
    ..Our studies indicate a central role for a chromatin-remodeling factor in the SSRI/p11 signaling pathway and suggest an approach to the development of improved antidepressant therapies. PAPERCLIP: ..
  38. Jolly C, Winfree S, Hansen B, Steele Mortimer O. The Annexin A2/p11 complex is required for efficient invasion of Salmonella Typhimurium in epithelial cells. Cell Microbiol. 2014;16:64-77 pubmed publisher
    ..in a stable heterotetramer, with p11, which can interact with other proteins such as the giant phosphoprotein AHNAK. We show here that AnxA2, p11 and AHNAK are required for T3SS-mediated Salmonella invasion of cultured epithelial ..
  39. Lee I, You J, Ha K, Bae D, Suh P, Rhee S, et al. AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C. J Biol Chem. 2004;279:26645-53 pubmed
    ..recently shown that phospholipase C-gamma (PLC-gamma) is activated by the central repeated units (CRUs) of the AHNAK protein in the presence of arachidonic acid...
  40. Sudo H, Tsuji A, Sugyo A, Abe M, Hino O, Saga T. AHNAK is highly expressed and plays a key role in cell migration and invasion in mesothelioma. Int J Oncol. 2014;44:530-8 pubmed publisher
    ..One such protein, AHNAK, was highly expressed in all seven mesothelioma cell lines (211H, H28, H226, H2052, H2452, MESO1 and MESO4), but ..
  41. Zacharias U, Purfürst B, Schöwel V, Morano I, Spuler S, Haase H. Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release. J Muscle Res Cell Motil. 2011;32:271-80 pubmed publisher
    ..Therefore, we investigated whether ahnak would be influenced by alterations of the sarcolemma exemplified by dysferlin mutations known to render the ..
  42. Straub B, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, et al. A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. J Cell Sci. 2003;116:4985-95 pubmed
    ..The other complex contains ezrin, periplakin, periaxin and desmoyokin (and so is called the EPPD complex), usually together with moesin, spectrin(s) and plectin...
  43. Shao Y, Czymmek K, Jones P, Fomin V, Akanbi K, Duncan R, et al. Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells. Am J Physiol Cell Physiol. 2009;296:C1067-78 pubmed publisher
    ..In mechanosensitive tissues, a 700-kDa ahnak protein anchors VSCCs to the actin cytoskeleton via the beta(2)-subunit of the L-type Ca(v)1...
  44. Chen B, Wang J, Dai D, Zhou Q, Guo X, Tian Z, et al. AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer. J Exp Clin Cancer Res. 2017;36:65 pubmed publisher
    AHNAK, also known as desmoyokin, is a giant protein with the molecular size of approximately 700 kDa and exerts diverse functions in different types of cancer...
  45. Johnson E, Zhang L, Adams M, Phillips A, Freitas M, Froehner S, et al. Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins. PLoS ONE. 2012;7:e43515 pubmed publisher
    ..In addition, our findings support the existence of cardiac-specific functions of dystrophin and may guide studies into early triggers of cardiac disease in Duchenne and Becker muscular dystrophies. ..
  46. Stiff T, Shtivelman E, Jeggo P, Kysela B. AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation. DNA Repair (Amst). 2004;3:245-56 pubmed
    b>AHNAK is a high molecular weight protein that is under-expressed in several radiosensitive neuroblastoma cell lines...
  47. Silva T, Smuczek B, Valadão I, Dzik L, Iglesia R, Cruz M, et al. AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility. Oncotarget. 2016;7:49998-50016 pubmed publisher
    ..found that over 1% of the entire proteome is represented in these vesicles, with the neuroblast differentiation associated protein AHNAK and annexin A2 being the most abundant...
  48. McKuen M, Mueller K, Bae Y, Fields K. Fluorescence-Reported Allelic Exchange Mutagenesis Reveals a Role for Chlamydia trachomatis TmeA in Invasion That Is Independent of Host AHNAK. Infect Immun. 2017;85: pubmed publisher
    ..The in vitro defect was reflected by impaired invasion of host cells. TmeA binds human AHNAK, and we demonstrate here that AHNAK is transiently recruited by invading chlamydiae...
  49. Tompkins V, Hagen J, Zediak V, Quelle D. Identification of novel ARF binding proteins by two-hybrid screening. Cell Cycle. 2006;5:641-6 pubmed
    ..The potential physiological roles of these novel ARF binding proteins in regulating ARF signaling are discussed. ..
  50. Cui X, Zhu W, Wang P, Wang X. Tetrandrine Inhibits the Intracellular Calcium Ion Level and Upregulates the Expression of Brg1 and AHNAK in Hep-2 Cells. Clin Lab. 2015;61:1569-76 pubmed
    ..The mRNA and protein expression of Brgl and AHNAK were evaluated by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and ..
  51. Ahn J, Chung K, Kim D, Won M, Kim L, Kim K, et al. Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. J Biochem Mol Biol. 2004;37:741-8 pubmed
    ..NS5A-F, NS5A-B and NS5A-C gave two, two and 10 candidate clones, respectively, including an AHNAK-related protein, the secreted frizzled-related protein 4 (SFRP4), the N-myc downstream regulated gene 1 (NDRG1), ..
  52. Sheppard H, Feisst V, Chen J, Print C, Dunbar P. AHNAK is downregulated in melanoma, predicts poor outcome, and may be required for the expression of functional cadherin-1. Melanoma Res. 2016;26:108-16 pubmed publisher
    ..Two proteins, AHNAK and ANXA2, were significantly downregulated in the melanoma cell lines compared with melanocytes...
  53. Lim H, Kim J, Park C, Lee S, Lee M, Kim K, et al. Regulation of c-Myc Expression by Ahnak Promotes Induced Pluripotent Stem Cell Generation. J Biol Chem. 2016;291:752-61 pubmed publisher
    We have previously reported that Ahnak-mediated TGFβ signaling leads to down-regulation of c-Myc expression...
  54. Garg A, O Rourke J, Long C, Doering J, Ravenscroft G, Bezprozvannaya S, et al. KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy. J Clin Invest. 2014;124:3529-39 pubmed publisher
    ..Loss of sarcomere thin filament proteins is a frequent cause of NM; therefore, our data that KLHL40 stabilizes NEB and LMOD3 provide a potential basis for the development of NM in KLHL40-deficient patients. ..
  55. De Seranno S, Benaud C, Assard N, Khediri S, Gerke V, Baudier J, et al. Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer. J Biol Chem. 2006;281:35030-8 pubmed
    ..binding assay that Annexin2 is required for strong binding of S100A10 to the C-terminal domain of the protein Ahnak. We also revealed that this effect involves only the Annexin2 N-terminal tail, which is implicated in S100A10/..
  56. Wernyj R, Ewing C, Isaacs W. Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery. Cell Motil Cytoskeleton. 2001;50:101-13 pubmed
    ..Sequencing of peptide fragments of the immunopurified protein reveals identity to AHNAK, a nuclear phosphoprotein, an identification that was confirmed by Western blot analysis with antibodies to AHNAK ..
  57. Ozorowski G, Milton S, Luecke H. Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2. Acta Crystallogr D Biol Crystallogr. 2013;69:92-104 pubmed publisher
    b>AHNAK, a large 629 kDa protein, has been implicated in membrane repair, and the annexin A2-S100A10 heterotetramer [(p11)(2)(AnxA2)(2))] has high affinity for several regions of its 1002-amino-acid C-terminal domain...