Gene Symbol: AGTR2
Description: angiotensin II receptor type 2
Alias: AT2, ATGR2, MRX88, type-2 angiotensin II receptor, angiotensin II type-2 receptor
Species: human
Products:     AGTR2

Top Publications

  1. Schmieder R, Erdmann J, Delles C, Jacobi J, Fleck E, Hilgers K, et al. Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. J Am Coll Cardiol. 2001;37:175-82 pubmed
    Our study goal was to analyze whether gene variants of angiotensin II type 2-receptor (AT2-R) modulate the effects of angiotensin II on the left ventricle (LV)...
  2. Zhang M, Ma H, Wang B, Zhao Y. Angiotensin II type 2 receptor gene polymorphisms and cardioprotective role in essential hypertension. Heart Vessels. 2006;21:95-101 pubmed
    b>Angiotensin II type 2 receptor (AT2R) has been proved to be involved in a cardioprotective role, but only a few studies have addressed the association of AT2R-genotype with this role...
  3. Li H, Qi Y, Li C, Braseth L, Gao Y, Shabashvili A, et al. Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells. Mol Cancer Ther. 2009;8:3255-65 pubmed publisher
  4. Doi C, Egashira N, Kawabata A, Maurya D, Ohta N, Uppalapati D, et al. Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice. BMC Cancer. 2010;10:67 pubmed publisher
    ..To evaluate the effect of angiotensin II (Ang II) type 2 receptor (AT2) expression in the host's body on the growth of pancreatic carcinoma, we have investigated the growth of mouse ..
  5. Jones A, Dhamrait S, Payne J, Hawe E, Li P, Toor I, et al. Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension. Hypertension. 2003;42:500-6 pubmed
    ..These data are important to our understanding of the divergent role of angiotensin II acting at its receptor subtypes and coronary disease pathogenesis and for the development of future cardiovascular therapies. ..
  6. Kotani K, Sakane N, Saiga K, Tsuzaki K, Sano Y, Mu H, et al. The angiotensin II type 2 receptor gene polymorphism and body mass index in healthy Japanese women. Ann Clin Biochem. 2007;44:83-5 pubmed
    Angiotensin II (AngII), through the AngII type 2 receptor (AT2-R), might exert some effect on adipocyte- and lipogenesis-related biology...
  7. Marciante K, Bis J, Rieder M, Reiner A, Lumley T, Monks S, et al. Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients. Am J Epidemiol. 2007;166:19-27 pubmed
    ..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke. ..
  8. Katsuya T, Horiuchi M, Minami S, Koike G, Santoro N, Hsueh A, et al. Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome. Mol Cell Endocrinol. 1997;127:221-8 pubmed
    ..We examined the entire coding sequence of this receptor in two different families of sisters with premature ovarian failure (POF) but found no changes in nucleotide sequences. ..
  9. Jin J, Nakura J, Wu Z, Yamamoto M, Abe M, Chen Y, et al. Association of angiotensin II type 2 receptor gene variant with hypertension. Hypertens Res. 2003;26:547-52 pubmed
    ..distinct subtypes of angiotensin II receptors, the angiotensin II type 1 receptor (AT1-R) and the angiotensin II type 2 receptor (AT2-R). Thus, the AT2-R gene may be involved in hypertension...

More Information

Publications128 found, 100 shown here

  1. Berry C, Touyz R, Dominiczak A, Webb R, Johns D. Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. Am J Physiol Heart Circ Physiol. 2001;281:H2337-65 pubmed
    ..This may be clinically relevant, inasmuch as inhibitors of the RAS are increasingly used in treatment of hypertension and coronary heart disease, where activation of the RAS is recognized...
  2. Pettersson Fernholm K, Fröjdö S, Fagerudd J, Thomas M, Forsblom C, Wessman M, et al. The AT2 gene may have a gender-specific effect on kidney function and pulse pressure in type I diabetic patients. Kidney Int. 2006;69:1880-4 pubmed
    ..The angiotensin II type 2 receptor (AT2), present in the renal glomerulus, may oppose the deleterious effects of the type I receptor (AT1)..
  3. Brzozowski T, Ptak Belowska A, Kwiecien S, Krzysiek Maczka G, Strzalka M, Drozdowicz D, et al. Novel concept in the mechanism of injury and protection of gastric mucosa: role of renin-angiotensin system and active metabolites of angiotensin. Curr Med Chem. 2012;19:55-62 pubmed
    ..The ANG II acting via its binding to two major receptor subtypes the ANG type 1 (AT1) and type 2 (AT2) has been shown be activated during stress and to contribute to the pathogenesis of cold stress- and ischemia-..
  4. Geraldes V, Goncalves Rosa N, Tavares C, Paton J, Rocha I. Reversing gene expression in cardiovascular target organs following chronic depression of the paraventricular nucleus of hypothalamus and rostral ventrolateral medulla in spontaneous hypertensive rats. Brain Res. 2016;1646:109-115 pubmed publisher
    ..In the kidney of SHR with LVhKir2.1 injections in PVN and RVLM, angiotensinogen, angiotensin II receptor2 (AT2) and endothelin1 were all upregulated compared to sham...
  5. Ibarra Lara L, del Valle Mondragon L, Soria Castro E, Torres Narváez J, Perez Severiano F, Sánchez Aguilar M, et al. Peroxisome proliferator-activated receptor-? stimulation by clofibrate favors an antioxidant and vasodilator environment in a stressed left ventricle. Pharmacol Rep. 2016;68:692-702 pubmed publisher
    ..The left ventricle was obtained to measure: angiotensin II and -(1-7), AT1 and AT2 receptors, angiotensin converting enzyme (ACE)-1 and -2, and MAS receptor; the activity and expression of ..
  6. Pang T, Wang J, Benicky J, Sánchez Lemus E, Saavedra J. Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways. J Neuroinflammation. 2012;9:102 pubmed publisher
    ..We found that SK-N-SH neuroblasts expressed AT1 but not AT2 receptor mRNA...
  7. Nguyen H, Nguyen H, Islam M, Obi T, Pothinuch P, Zar P, et al. Pharmacological characteristics of Artemisia vulgaris L. in isolated porcine basilar artery. J Ethnopharmacol. 2016;182:16-26 pubmed publisher
    ..Pretreatment with PD123319 (an AT2 receptor antagonist), Nω-nitro-L-arginine (a nitric oxide synthase inhibitor), or both, also enhanced this ..
  8. Lee D, Kim H, Won K, Lee K, Jung S, Park E, et al. DJ-1 regulates the expression of renal (pro)renin receptor via reactive oxygen species-mediated epigenetic modification. Biochim Biophys Acta. 2015;1850:426-34 pubmed publisher
    ..was greater in DJ-1-/- than in DJ-1+/+ cells and this was inhibited by a PRR-inhibitory peptide, and by AT1 and AT2 receptor inhibitors...
  9. Dilauro M, Burns K. Angiotensin-(1-7) and its effects in the kidney. ScientificWorldJournal. 2009;9:522-35 pubmed publisher
    ..mediates its effects via binding to kidney Mas receptors, although some actions may occur via Ang II AT1 or AT2 receptors. In vitro studies suggest that Ang-(1-7) is an intrarenal vasodilator...
  10. Verdonk K, Saleh L, Lankhorst S, Smilde J, van Ingen M, Garrelds I, et al. Association studies suggest a key role for endothelin-1 in the pathogenesis of preeclampsia and the accompanying renin-angiotensin-aldosterone system suppression. Hypertension. 2015;65:1316-23 pubmed publisher
    ..Subcutaneous arteries obtained from patients with preeclampsia displayed an enhanced, AT2 receptor-mediated response to angiotensin II...
  11. Dominguez Meijide A, Rodriguez Perez A, Díaz Ruiz C, Guerra M, Labandeira Garcia J. Dopamine modulates astroglial and microglial activity via glial renin-angiotensin system in cultures. Brain Behav Immun. 2017;62:277-290 pubmed publisher
    ..of angiotensinogen, decreased expression of angiotensin type-1 (AT1) receptors and increased expression of AT2 receptors. In microglia, dopamine and dopamine agonists also regulated RAS activity...
  12. Passaglia P, Ceron C, Mecawi A, Antunes Rodrigues J, Coelho E, Tirapelli C. Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress. Vascul Pharmacol. 2015;74:49-59 pubmed publisher
    ..Ethanol intake did not alter protein expression of ACE, AT1 or AT2 receptors in both aorta and MAB...
  13. Wang J, Lu L, Wang Y, Wu Y, Han J, Wang W, et al. Qishenyiqi Dropping Pill attenuates myocardial fibrosis in rats by inhibiting RAAS-mediated arachidonic acid inflammation. J Ethnopharmacol. 2015;176:375-84 pubmed publisher inhibiting RAAS-activated pathway, as indicated by decreased angiotensin type 1 receptor (AT1) and increased AT2 expression...
  14. Tang J, Li N, Chen X, Gao Q, Zhou X, Zhang Y, et al. Prenatal Hypoxia Induced Dysfunction in Cerebral Arteries of Offspring Rats. J Am Heart Assoc. 2017;6: pubmed publisher
    ..AII-mediated MCA constriction was greater in male offspring exposed to prenatal hypoxia. AT1 and AT2 receptors were involved in the altered AII-mediated vasoconstriction...
  15. Milanez M, Nishi E, Sato A, Futuro Neto H, Bergamaschi C, Campos R. Control of renal sympathetic nerve activity by neurotransmitters in the spinal cord in Goldblatt hypertension. Brain Res. 2018;1698:43-53 pubmed publisher
    ..of AT1 gene expression in the T11-12 spinal segments in the 2K1C group but no change in gene expression for AT2 or ionotropic glutamate (NMDA, kainate and AMPA) receptors...
  16. Araújo F, Milsted A, Watanabe I, Del Puerto H, Santos R, Lazar J, et al. Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters. Physiol Genomics. 2015;47:177-86 pubmed publisher
    ..Both SRY and SOX3 upregulated the promoter of Angiotensinogen (AGT) and downregulated the promoters of ACE2, AT2, and MAS, likely through overlapping mechanisms...
  17. Kim S, Cheresh P, Jablonski R, Morales Nebreda L, Cheng Y, Hogan E, et al. Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage. Free Radic Biol Med. 2016;101:482-490 pubmed publisher
    ..AEC (primary AT2 cells from WT and MCAT mice and MLE-12 cells) mtDNA damage was assessed by a quantitative PCR-based assay, ..
  18. Chakrabarty A, Liao Z, Mu Y, Smith P. Inflammatory Renin-Angiotensin System Disruption Attenuates Sensory Hyperinnervation and Mechanical Hypersensitivity in a Rat Model of Provoked Vestibulodynia. J Pain. 2018;19:264-277 pubmed publisher
    ..The model confirms a crucial role of the local inflammatory renin-angiotensin system in hypersensitivity and hyperinnervation. Targeting this system holds promise for developing new nonopioid analgesic treatment strategies. ..
  19. Katayama I, Pereira R, Dopona E, Shimizu M, Furukawa L, Oliveira I, et al. High-salt intake induces cardiomyocyte hypertrophy in rats in response to local angiotensin II type 1 receptor activation. J Nutr. 2014;144:1571-8 pubmed publisher
    ..thiobarbituric acid-reactive substances, and binding of conformation-specific anti-AT1 and anti-angiotensin II type 2 receptor (AT2) antibodies in the 2 ventricles were measured...
  20. Fang Y, Zhong R, Sun X, Zhou D. High salt diet decreases reproductive performance in rams and down-regulates gene expression of some components of the renin-angiotensin system in the testis. Theriogenology. 2018;107:127-133 pubmed publisher
    ..Regarding components of the testicular RAS, the 12% salt diet decreased (P <0.05) expression of REN, Ang II and AT2 mRNA, although ACE and AT1 were unaffected. Furthermore, the 12% salt diet decreased (P <0...
  21. Burson J, Aguilera G, Gross K, Sigmund C. Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol. 1994;267:E260-7 pubmed
    ..1 cells, a renin-expressing mouse kidney tumoral cell line. Receptor binding and competition assays using AT1- and AT2-receptor antagonists revealed that only AT1 receptors are present on the cell surface...
  22. Xue Q, Xiao D, Zhang L. Estrogen Regulates Angiotensin II Receptor Expression Patterns and Protects the Heart from Ischemic Injury in Female Rats. Biol Reprod. 2015;93:6 pubmed publisher
    ..of glucocorticoid receptor (GR) to glucocorticoid response elements at angiotensin II type 1 (Agtr1) and type 2 (Agtr2) receptor promoters, resulting in a decrease in Agtr1 and an increase in Agtr2 in the heart...
  23. Kato H, Ishida J, Matsusaka T, Ishimaru T, Tanimoto K, Sugiyama F, et al. Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways. PLoS ONE. 2015;10:e0129484 pubmed publisher
    ..To genetically determine the responsible receptor subtype, we examined AT1a, AT1b, and AT2 knockout mice, but did not observe anemia in any of them...
  24. Lunardelli A, Luft C, Pedrazza L, Martha B, de Oliveira J, Donadio M. Effects of neonatal inflammation on the inflammatory and oxidative profile during experimental sepsis in adult life. Physiol Behav. 2015;151:516-24 pubmed publisher
    ..administration of LPS increased the mRNA expression of the AT1 receptor and decreased the mRNA expression of the AT2 receptor in the adrenal glands of males...
  25. Campbell C, Fang B, Guo X, Peralta C, Psaty B, Rich S, et al. Associations between genetic variants in the ACE, AGT, AGTR1 and AGTR2 genes and renal function in the Multi-ethnic Study of Atherosclerosis. Am J Nephrol. 2010;32:156-62 pubmed publisher
    ..enzyme (ACE), angiotensinogen (AGT), angiotensin II type I receptor (AGTR1) and angiotensin II type II receptor (AGTR2) genes may contribute to renal function variation...
  26. Karnik S, Unal H, Kemp J, Tirupula K, Eguchi S, Vanderheyden P, et al. International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected]. Pharmacol Rev. 2015;67:754-819 pubmed publisher
    ..of three G-protein-coupled receptors—the angiotensin II type 1 receptor (AT1 receptor), the angiotensin II type 2 receptor (AT2 receptor), the MAS receptor—and a type II trans-membrane zinc protein—the candidate ..
  27. Khanmoradi M, Nasimi A. Functions of AT1 and AT2 angiotensin receptors in the paraventricular nucleus of the rat, correlating single-unit and cardiovascular responses. Brain Res Bull. 2017;132:170-179 pubmed publisher
    ..The PVN contains angiotensin II (AngII) immunoreactive cells, fibers, as well as AT1 and AT2 receptors of AngII...
  28. Kadakol A, Goru S, Malek V, Gaikwad A. Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgf?1 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats. Biomed Pharmacother. 2017;95:1461-1468 pubmed publisher
    ..mechanisms of target tissues to alter the abundance of angiotensin II type 1 receptor (AT1) and angiotensin II type 2 receptor (AT2)...
  29. Kook S, Qi A, Wang P, Meng S, Gulleman P, Young L, et al. Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes. Am J Respir Cell Mol Biol. 2018;58:566-574 pubmed publisher
    ..syndrome (HPS) is often complicated by loss of the differentiated phenotype of cultured primary alveolar type 2 (AT2) cells, as well as by a lack of durable cell lines that are faithful to both AT2-cell and rare disease phenotypes...
  30. Alfakih K, Brown B, Lawrance R, Warburton P, Maqbool A, Walters K, et al. Effect of a common X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) on the occurrence of premature myocardial infarction and stenotic atherosclerosis requiring revascularization. Atherosclerosis. 2007;195:e32-8 pubmed
    To assess the association of the angiotensin II type 2 (AT2) receptor (-1332 G/A) gene polymorphism with premature coronary artery disease (CAD) and investigate for a further role in both myocardial infarction and predominantly stenotic ..
  31. Siomou E, Bouba I, Kollios K, Papadopoulou F, Syrrou M, Georgiou I, et al. Angiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tract. Pediatr Res. 2007;62:83-7 pubmed
    The A-1332G transition of the angiotensin II type 2 receptor (AT2R) gene was found to occur more often in males with ureteropelvic (UPJO) or ureterovesical junction obstruction (UVJO)...
  32. Taylor W, Steffens D, Ashley Koch A, Payne M, MacFall J, Potocky C, et al. Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men. Mol Psychiatry. 2010;15:816-22 pubmed publisher
    ..volume and polymorphisms in genes coding for the angiotensin-II type 1 and type 2 receptors, AGTR1 A1166C and AGTR2 C3123A, respectively. 137 depressed and 94 non-depressed participants aged >or=60 years were enrolled...
  33. Sotoodehnia N, Li G, Johnson C, Lemaitre R, Rice K, Rea T, et al. Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk. Heart Rhythm. 2009;6:1306-14 pubmed publisher
    ..descent were genotyped for 47 single nucleotide polymorphisms (SNPs) in eight genes (ACE, AGT, REN, AGTR1, AGTR2, ACE2, KNG1, BDKRB2). The association of SNPs and haplotypes with SCA risk was examined using logistic regression...
  34. Zhu Y, Fu J, Yang H, Pan Y, Yao L, Xue X. Hyperoxia-induced methylation decreases RUNX3 in a newborn rat model of bronchopulmonary dysplasia. Respir Res. 2015;16:75 pubmed publisher
    ..Lung tissues and alveolar type 2 (AT2) epithelial cells were collected between 1-14 days...
  35. Tovar H, García Herrera R, Espinal Enríquez J, Hernández Lemus E. Transcriptional master regulator analysis in breast cancer genetic networks. Comput Biol Chem. 2015;59 Pt B:67-77 pubmed publisher
    ..We found that transcription factors such as AGTR2, ZNF132, TFDP3 and others are master regulators in this gene regulatory network...
  36. Ogata Y, Nemoto W, Nakagawasai O, Yamagata R, Tadano T, Tan No K. Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice. Mol Pharmacol. 2016;90:205-13 pubmed publisher intrathecal administration of losartan, an Ang II type 1 (AT1) receptor antagonist, but not by PD123319, an AT2 receptor antagonist...
  37. Romano Spica V, Mettimano M, Ianni A, Specchia M, Ricciardi G, Savi L. Epidemiology of essential hypertension: the role of genetic polymorphism. Eur J Epidemiol. 2003;18:211-9 pubmed
    ..Genetic data and methods are contributing more and more to epidemiological studies of complex diseases, and their application is influenced by information availability and Genome Project results. ..
  38. Senbonmatsu T, Saito T, Landon E, Watanabe O, Price E, Roberts R, et al. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J. 2003;22:6471-82 pubmed
    ..PLZF is expressed robustly in the heart in contrast to many other tissues. This cardiac selective pathway involving AT(2), PLZF and p85 alpha PI3K may explain the absence of a cardiac hypertrophic response in AT(2) gene-deleted mice. ..
  39. Plummer S, Tower C, Alonso P, Morgan L, Baker P, Broughton Pipkin F, et al. Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia. Hum Mutat. 2004;24:14-20 pubmed
    ..These effects are controlled through two main receptor subtypes: AGTR1 and AGTR2. We studied the haplotype frequencies of both receptor genes in women with preeclamptic pregnancies and ..
  40. Huang D, Sun W, Strom C. Sequence variations in AGTR2 are unlikely to be associated with X-linked mental retardation. Am J Med Genet A. 2005;139:243-4 pubmed
  41. Procopciuc L, Caracostea G, Zaharie G, Puscas M, Iordache G, Popa M, et al. Maternal/newborn genotype contribution of the renin-angiotensin system (Met235Thr, Thr174Met, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A- AT2R2, 83A/G-REN) to the risk of pre-eclampsia: a Romanian study. J Renin Angiotensin Aldosterone Syst. 2011;12:539-48 pubmed publisher
    ..01), 3.33 (p = 0.006), 2.72 (p = 0.04) and 7.8 (p < 0.01), respectively. The results of our study confirm that, in pre-eclampsia, both maternal and newborn genetic variations implicated in blood pressure regulation are important. ..
  42. Liao Z, Chakrabarty A, Mu Y, Bhattacherjee A, Goestch M, Leclair C, et al. A Local Inflammatory Renin-Angiotensin System Drives Sensory Axon Sprouting in Provoked Vestibulodynia. J Pain. 2017;18:511-525 pubmed publisher
    ..and sensory axon sprouting are prevented by blocking effects of angiotensin II on angiotensin II receptor type 2 (AT2) receptors...
  43. Yayama K, Hiyoshi H, Imazu D, Okamoto H. Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor. Hypertension. 2006;48:958-64 pubmed
    Abdominal aortic banding in mice induces upregulation of angiotensin II (Ang II) type 2 (AT2) receptors in the pressure-overloaded thoracic aorta...
  44. AbdAlla S, Lother H, el Missiry A, Langer A, Sergeev P, el Faramawy Y, et al. Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease. J Biol Chem. 2009;284:6554-65 pubmed publisher brains of AD patients and mice correlated with the appearance of cross-linked oligomeric angiotensin II AT2 receptors sequestering Galphaq/11...
  45. Azevedo H, Fujita A, Bando S, Iamashita P, Moreira Filho C. Transcriptional network analysis reveals that AT1 and AT2 angiotensin II receptors are both involved in the regulation of genes essential for glioma progression. PLoS ONE. 2014;9:e110934 pubmed publisher
    ..C6 cells were treated with Ang II and specific antagonists of AT1 and AT2 receptors...
  46. Yoshikawa M. Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects. Peptides. 2015;72:208-25 pubmed publisher
    ..anxiolytic-like antihypertensive and anti-alopecia effects via different types of receptors such as OT, FPR and AT2 were also obtained...
  47. Sallander J, Wallinder C, Hallberg A, Åqvist J, Gutiérrez de Terán H. Structural determinants of subtype selectivity and functional activity of angiotensin II receptors. Bioorg Med Chem Lett. 2016;26:1355-9 pubmed publisher
    Agonists of the angiotensin II receptor type 2 (AT2), a G-protein coupled receptor, promote tissue protective effects in cardiovascular and renal diseases, while antagonists reduce neuropathic pain...
  48. Kemp B, Howell N, Keller S, Gildea J, Padia S, Carey R. AT2 Receptor Activation Prevents Sodium Retention and Reduces Blood Pressure in Angiotensin II-Dependent Hypertension. Circ Res. 2016;119:532-43 pubmed publisher
    Compound 21 (C-21) is a highly selective nonpeptide angiotensin AT2 receptor (AT2R) agonist...
  49. Kim S, Cheresh P, Eren M, Jablonski R, Yeldandi A, Ridge K, et al. Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis. Am J Physiol Lung Cell Mol Physiol. 2017;313:L16-L26 pubmed publisher
    ..We find that Klotho levels are decreased in both serum and alveolar type II (AT2) cells from asbestos-exposed mice...
  50. Akcay A, Sezer S, Ozdemir F, Arat Z, Atac F, Verdi H, et al. Association of the genetic polymorphisms of the renin-angiotensin system and endothelial nitric oxide synthase with chronic renal transplant dysfunction. Transplantation. 2004;78:892-8 pubmed
    ..The graft function was not affected by AGT, ATR1, ATR2, and ENOS gene polymorphisms. These findings suggest that the DD variant of the ACE gene polymorphism is associated with increased risk of developing CAD. ..
  51. Liu H, Cheng B, Yu W, Sun R, Tang J, Fu X. [Role of angiotensin II receptors in proliferation of fibroblast derived from human hypertrophic scars]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2007;23:36-9 pubmed
    The present study was undertaken to observe the expression of angiotensin II (Ang II) type 1 (AT1) and type 2 (AT2) receptors in human hypertrophic scars, and explore their role in the proliferation of fibroblasts in human hypertrophic ..
  52. Pedersen Bjergaard U, Dhamrait S, Sethi A, Frandsen E, Nordestgaard B, Montgomery H, et al. Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes. Am J Med. 2008;121:246.e1-8 pubmed publisher
    ..A potential preventive effect of renin-angiotensin system blocking drugs in patients with recurrent severe hypoglycemia merits further investigation. ..
  53. Xing Sheng Y, Yong Zhi L, Jie Xin L, Yu Qing G, Zhang Huang C, Chong Fa Z, et al. Genetic influence on baroreflex sensitivity in normotensive young men. Am J Hypertens. 2010;23:655-9 pubmed publisher
    ..Three polymorphisms that are associated with the variation in BRS were identified in the eNOS, CYP11B2, and B2R genes, respectively; overall, they accounted for 16% of the BRS variation. ..
  54. Zulli A, Hare D, Buxton B, Widdop R. Vasoactive role for angiotensin II type 2 receptors in human radial artery. Int J Immunopathol Pharmacol. 2014;27:79-85 pubmed
    ..We conclude that inhibition of AT2R can enhance or reduce angiotensin II-mediated vasoconstriction. These data indicate that the role of AT2R in human diseased arteries is divergent although the AT2R-mediated vasorelaxation prevails. ..
  55. Pandey A, Goru S, Kadakol A, Malek V, Sharma N, Gaikwad A. H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats. Biochimie. 2016;131:68-76 pubmed publisher
    ..II mediated macrophage infiltration in T2DN is regulated at least partially by H2AK119Ub through both AT1 and AT2 receptors, which to the best of our knowledge, presents the first report for the regulation of Mcp1 by H2AK119Ub...
  56. Hashizume K, Mashima Y, Fumayama T, Ohtake Y, Kimura I, Yoshida K, et al. Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population. Invest Ophthalmol Vis Sci. 2005;46:1993-2001 pubmed
    ..ACE/insertion(I)-deletion(D); CMA/-1930A-->G; AGTR1/-731T-->G, AGTR1/-521C-->T, and AGTR1/1166A-->C; AGTR2/3123C-->A; and CYP11B2/-344T-->C were examined...
  57. Xu M, Sham P, Ye Z, Lindpaintner K, He L. A1166C genetic variation of the angiotensin II type I receptor gene and susceptibility to coronary heart disease: collaborative of 53 studies with 20,435 cases and 23,674 controls. Atherosclerosis. 2010;213:191-9 pubmed publisher
    ..There were no significant associations among the larger sample-size and high-quality studies which are less prone to selective publication and have greater power to detect a true association. ..
  58. Porrello E, Pfleger K, Seeber R, Qian H, Oro C, Abogadie F, et al. Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles. Cell Signal. 2011;23:1767-76 pubmed publisher
  59. Rahimi Z, Rahimi Z, Aghaei A, Vaisi raygani A. AT2R -1332 G:A polymorphism and its interaction with AT1R 1166 A:C, ACE I/D and MMP-9 -1562 C:T polymorphisms: risk factors for susceptibility to preeclampsia. Gene. 2014;538:176-81 pubmed publisher
    ..Our findings suggest that the renin-angiotensin system (RAS) variants and gene-gene interactions affect the risk of preeclampsia. ..
  60. Bennion D, Jones C, Dang A, Isenberg J, Graham J, Lindblad L, et al. Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach. Clin Sci (Lond). 2018;132:581-593 pubmed publisher
  61. Williams P, Mistry H, Innes B, Bulmer J, Broughton Pipkin F. Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human. Placenta. 2010;31:448-55 pubmed publisher
    ..This study has characterised expression of AT4R and AT1R and AT2R in human placenta throughout normal pregnancy and in PE. Both AngIV and AngII may play an important role in normal pregnancy. ..
  62. Presta I, Tassone E, Andreozzi F, Perticone M, Sciacqua A, Laino I, et al. Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in HUVECs. Atherosclerosis. 2011;219:463-7 pubmed publisher
    ..Therefore, a possible positive role of an AT(2)-R overstimulation in condition of AT(1)-R antagonism seems to be irrelevant. ..
  63. Castoldi G, di Gioia C, Carletti R, Roma F, Zerbini G, Stella A. Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood pressure independent effect. Biosci Rep. 2016;36: pubmed publisher
    ..These data suggest that C21 may counteract tubulo-interstitial fibrosis, the most potent predictor of the progression of renal diseases. ..
  64. Haznedaroglu I, Malkan U. Local bone marrow renin-angiotensin system in the genesis of leukemia and other malignancies. Eur Rev Med Pharmacol Sci. 2016;20:4089-4111 pubmed
    ..Most of the RAS molecules including ACE, ACE2, AGT, AGTR1, AGTR2, AKR1C4, AKR1D1, ANPEP, ATP6AP2, CMA1, CPA3, CTSA, CTSD, CTSG, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, DPP3, ..
  65. Micozkadioglu H, Colak T, Akcay A, Sezer S, Atac F, Verdi H, et al. Angiotensin-converting enzyme gene polymorphism significantly affects renal posttransplantation erythrocytosis. Transplant Proc. 2004;36:161-3 pubmed
    ..05, RR = 7.714 and P <.03, RR = 10.199, respectively). While previous studies revealed a relation between angiotensin II and PE, our study discovered the contribution of ACE gene polymorphism. ..
  66. Fritz R, Radziwill G. The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor. Biochem Biophys Res Commun. 2005;338:1906-12 pubmed
    ..The angiotensin II type 2 (AT2) receptor belongs to the class of G protein-coupled receptors and also promotes antiproliferative effects...
  67. Hernandez Schulman I, Zhou M, Raij L. Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans. Hypertension. 2007;49:270-1 pubmed
  68. Xie L, Zhou D, Xiong J, You J, Zeng Y, Peng L. Paraquat induce pulmonary epithelial-mesenchymal transition through transforming growth factor-β1-dependent mechanism. Exp Toxicol Pathol. 2016;68:69-76 pubmed publisher
    ..factor β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of Type II alveolar epithelial cells (AT2) contributed to the pulmonary fibrosis in some pulmonary disease...
  69. Zha D, Cheng H, Li W, Wu Y, Li X, Zhang L, et al. High glucose instigates tubulointerstitial injury by stimulating hetero-dimerization of adiponectin and angiotensin II receptors. Biochem Biophys Res Commun. 2017;493:840-846 pubmed publisher
    ..Here we report that high glucose stimulates expression of angiotensin II (AngII) receptors (AT1 and AT2) in renal proximal tubular epithelial cells (NRK-52E)...
  70. Juarez E, Tufiño C, Querejeta E, Bracho Valdés I, Bobadilla Lugo R. Evidence of changes in alpha-1/AT1 receptor function generated by diet-induced obesity. Diab Vasc Dis Res. 2017;14:485-493 pubmed publisher
    ..Diet-induced obesity did not change angiotensin II AT1, AT2 receptor proteins expression but reduced COX-1 and NOS2 ( p?<?0.05 vs standard diet)...
  71. Leung K, Liang J, Ma M, Leung P. Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation. Stem Cells. 2012;30:525-36 pubmed publisher
    ..These data strongly indicate that a local RAS is involved in governing the functional maturation of pancreatic progenitors toward the endocrine lineage. ..
  72. Yamamoto Y, Gotoh S, Korogi Y, Seki M, Konishi S, Ikeo S, et al. Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. Nat Methods. 2017;14:1097-1106 pubmed publisher
    ..Alveolar epithelial type II (AT2) cells function as tissue stem cells in the lung, but robust models for studying human AT2 cells are lacking...
  73. Tower C, Lui S, Charlesworth N, Smith S, Aplin J, Jones R. Differential expression of angiotensin II type 1 and type 2 receptors at the maternal-fetal interface: potential roles in early placental development. Reproduction. 2010;140:931-42 pubmed publisher
    ..It acts through two receptor subtypes, AGTR1 and AGTR2 (AT1 and AT2), which typically mediate antagonising actions...
  74. Hilliard L, Mirabito K, Denton K. Unmasking the potential of the angiotensin AT2 receptor as a therapeutic target in hypertension in men and women: what we know and what we still need to find out. Clin Exp Pharmacol Physiol. 2013;40:542-50 pubmed publisher
    ..In this context, it is now well established that the angiotensin AT2 receptor (AT2 R) elicits depressor and natriuretic effects and that these effects are greater in females due to ..
  75. Palatini P, Ceolotto G, Dorigatti F, Mos L, Santonastaso M, Bratti P, et al. Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome. Am J Hypertens. 2009;22:208-14 pubmed publisher
    The aim of the study was to investigate the effect of polymorphism A1166C for AGTR1 and -1332G/A for AGTR2 on the incidence of sustained hypertension (HT) and metabolic syndrome in a cohort of young patients screened for stage 1 HT...
  76. Pan H, Cui Y, Zeng J. NF-?B mediates the survival of corneal myofibroblast induced by angiotensin II. Invest Ophthalmol Vis Sci. 2014;55:4220-8 pubmed publisher
    ..Ang II induces corneal myofibroblasts resistance to apoptosis via activating NF-?B signaling pathway, and thus should be further investigated as a possible target for therapy of corneal fibrosis. ..
  77. Saavedra J, Armando I. Angiotensin II AT2 Receptors Contribute to Regulate the Sympathoadrenal and Hormonal Reaction to Stress Stimuli. Cell Mol Neurobiol. 2018;38:85-108 pubmed publisher
    ..Conversely, the function of Angiotensin II AT2 receptors has not been totally clarified...
  78. Podhorska Okołów M, Dziegiel P, Gomułkiewicz A, Dolinska Krajewska B, Murawska Ciałowicz E, Jethon Z, et al. The role of AT1 and AT2 angiotensin receptors in the mechanism of apoptosis in renal tubular cells after physical exercise. Rocz Akad Med Bialymst. 2004;49 Suppl 1:8-10 pubmed
    ..Recent studies have shown that both AT1 and AT2 angiotensin receptors may play a role in mediating the apoptotic process in the kidney...
  79. Pawlikowski M, Winczyk K, Sledź B. Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors. Folia Histochem Cytobiol. 2008;46:51-5 pubmed publisher
    Angiotensin II is well known to affect the adrenal cell growth and function. Angiotensin receptors AT1 and AT2 were found to be present in the normal adrenal gland...
  80. Yang Q, Zhang X, Li L, Zhang R, Feng L, Mu J. Ponticoccus alexandrii sp. nov., a novel bacterium isolated from the marine toxigenic dinoflagellate Alexandrium minutum. Antonie Van Leeuwenhoek. 2018;111:995-1000 pubmed publisher
    ..toxin-producing marine dinoflagellate, Alexandrium minutum a novel algal-associated bacterium, designated strain AT2-AT was isolated...
  81. Konoshita T, Kato N, Fuchs S, Mizuno S, Aoyama C, Motomura M, et al. Genetic variant of the Renin-Angiotensin system and diabetes influences blood pressure response to Angiotensin receptor blockers. Diabetes Care. 2009;32:1485-90 pubmed publisher
    ..C-5312T, ACE insertion/deletion, angiotensinogen M235T, angiotensin II type 1 receptor A1166C, and angiotensin II type 2 receptor C3123A were assayed by PCR and restriction fragment-length polymorphism...
  82. Mao X, Zheng Y, Xiao K, Wei Y, Zhu Y, Cai Q, et al. OsPRX2 contributes to stomatal closure and improves potassium deficiency tolerance in rice. Biochem Biophys Res Commun. 2018;495:461-467 pubmed publisher
    ..In Arabidopsis thaliana At2-CysPrxB (At5g06290) has been demonstrated to be essential in maintaining the water-water cycle for proper H2
  83. Carl McGrath S, Ebert M, Lendeckel U, Rocken C. Expression of the local angiotensin II system in gastric cancer may facilitate lymphatic invasion and nodal spread. Cancer Biol Ther. 2007;6:1218-26 pubmed
    ..Our study provides evidence of the expression of the local angiotensin II system in lymph node metastases, and that ACE-, AT1R- and AT2R-activity promotes tumor cell invasion. ..
  84. Brugts J, De Maat M, Boersma E, Witteman J, van Duijn C, Uitterlinden A, et al. The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease. Cardiovasc Drugs Ther. 2009;23:171-81 pubmed publisher
  85. Pandey A, Gaikwad A. AT2 receptor agonist Compound 21: A silver lining for diabetic nephropathy. Eur J Pharmacol. 2017;815:251-257 pubmed publisher
    ..Compound 21 (C21), a novel non-peptide Angiotensin II type 2 receptor (AT2) agonist, recently granted orphan drug status for the treatment of a rare disease, ..
  86. Yang J, Zhou J, Xin Z, Zhao L, Yu M, Feng J, et al. Interactions among related genes of renin-angiotensin system associated with type 2 diabetes. Diabetes Care. 2010;33:2271-3 pubmed publisher
    ..In female subjects, the model of rs2106809 (ACE2), I/D (ACE), and rs1403543 (AGTR2) was significant (P = 0.012). This three-locus combination was associated with a 2.76 times (1.91-3.97; P < 0...
  87. Miranda D, Dos Santos A, Sarubi H, Bastos Rodrigues L, Rosa D, Freitas I, et al. Association of angiotensin type 2 receptor gene polymorphisms with ureteropelvic junction obstruction in Brazilian patients. Nephrology (Carlton). 2014;19:714-20 pubmed publisher
    ..Therefore, the gene encoding AT2 receptor, the AGTR2 gene located in the X chromosome, is a potential candidate for genetic association with Congenital Anomalies of ..
  88. Wang Z, Zhang J, Li F, Ji X, Liao L, Ma L, et al. Drug resistance-related mutations T369V/I in the connection subdomain of HIV-1 reverse transcriptase severely impair viral fitness. Virus Res. 2017;233:8-16 pubmed publisher
    ..Then, experiments on mutant and wild-type virus AT2 were performed separately using a growth-competition assay, and then the relative fitness was calculated...
  89. Xu X, He H, Hu S, Han J, Huang L, Xu J, et al. Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro. Stem Cell Res Ther. 2017;8:164 pubmed publisher
    ..This study provides insights into the mechanisms by which MSCs home to injury sites and will enable the rational design of targeted therapies to improve MSC engraftment. ..
  90. Ylisaukko Oja T, Rehnstrom K, Vanhala R, Tengström C, Lähdetie J, Jarvela I. Identification of two AGTR2 mutations in male patients with non-syndromic mental retardation. Hum Genet. 2004;114:211-3 pubmed
    Mutations in the coding region of the angiotensin II type 2 receptor gene (AGTR2) were recently identified to cause X-linked recessive mental retardation...
  91. Carstens N, van der Merwe L, Revera M, Heradien M, Goosen A, Brink P, et al. Genetic variation in angiotensin II type 2 receptor gene influences extent of left ventricular hypertrophy in hypertrophic cardiomyopathy independent of blood pressure. J Renin Angiotensin Aldosterone Syst. 2011;12:274-80 pubmed publisher
    ..rs1403543) and additional single nucleotide polymorphisms in the 3' untranslated region of the AT(2)R gene (AGTR2) on a heritable composite hypertrophy score in an HCM family cohort in which HCM founder mutations segregate...
  92. Soares E, Barbosa C, Campagnole Santos M, Santos R, Alzamora A. Hypotensive effect induced by microinjection of Alamandine, a derivative of angiotensin-(1-7), into caudal ventrolateral medulla of 2K1C hypertensive rats. Peptides. 2017;96:67-75 pubmed publisher
    ..Furthermore, microinjection of PD123319, a putative AT2 receptor antagonist blocked the hypotensive effect of alamandine, but not of angiotensin-(1-7), in Sham and 2K1C ..