Gene Symbol: AGTR1
Description: angiotensin II receptor type 1
Alias: AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, type-1 angiotensin II receptor, type-1B angiotensin II receptor
Species: human
Products:     AGTR1

Top Publications

  1. Suchankova P, Henningsson S, Olsson M, Baghaei F, Rosmond R, Holm G, et al. Association between the AGTR1 polymorphism +1166A>C and serum levels of high-sensitivity C-reactive protein. Regul Pept. 2009;152:28-32 pubmed publisher
    ..system (RAS) is of importance for the regulation of inflammation, and blockade of angiotensin II type 1 receptors (AGTR1) influences hsCRP levels...
  2. Rhodes D, Ateeq B, Cao Q, Tomlins S, Mehra R, Laxman B, et al. AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist. Proc Natl Acad Sci U S A. 2009;106:10284-9 pubmed publisher
    ..In addition to prioritizing ERBB2, we found AGTR1, the angiotensin II receptor type I, to be markedly overexpressed in 10-20% of breast cancer cases across multiple ..
  3. Benedetto C, Marozio L, Ciccone G, Chieppa G, Quaglia M, Matullo G, et al. Synergistic effect of renin-angiotensin system and nitric oxide synthase genes polymorphisms in pre-eclampsia. Acta Obstet Gynecol Scand. 2007;86:678-82 pubmed
    ..04, 95% CI=1.16-7.93). Synergism of angiotensin-converting enzyme I/D and other polymorphisms of renin-angiotensin system components and nitric oxide synthase may be a risk factor for pre-eclampsia. ..
  4. Hansen J, Aplin M, Hansen J, Christensen G, Bonde M, Schneider M, et al. The human angiotensin AT(1) receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation. Eur J Pharmacol. 2008;590:255-63 pubmed publisher
    ..The realization of G protein-independent signalling by the human angiotensin AT(1) receptor has clear pharmacological implications for development of drugs with pathway-specific actions and defined biological outcomes. ..
  5. Herse F, Verlohren S, Wenzel K, Pape J, Muller D, Modrow S, et al. Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study. Hypertension. 2009;53:393-8 pubmed publisher
    We showed earlier that activating autoantibodies against the angiotensin II type 1 (AT(1)) receptor (AT1-AA) circulate in preeclamptic women. They may be involved in the pathogenesis of preeclampsia...
  6. Farrag W, Eid M, El Shazly S, Abdallah M. Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essential hypertension. Mol Cell Biochem. 2011;351:13-8 pubmed publisher
    ..Further strategies for treating high-risk patients could result in prevention or delay of end organ damage. ..
  7. Möllsten A, Stegmayr B, Wiklund P. Genetic polymorphisms in the renin-angiotensin system confer increased risk of stroke independently of blood pressure: a nested case-control study. J Hypertens. 2008;26:1367-72 pubmed publisher
    ..were analyzed for potential risk factors including the A1166C polymorphism of the angiotensin II type I receptor (AT1R) gene and the functional insertion/deletion polymorphism of the angiotensin-converting enzyme gene...
  8. Marciante K, Bis J, Rieder M, Reiner A, Lumley T, Monks S, et al. Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients. Am J Epidemiol. 2007;166:19-27 pubmed
    ..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke. ..
  9. Mottl A, Shoham D, North K. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review. Genet Med. 2008;10:560-74 pubmed publisher
    The angiotensin II type 1 receptor (AGTR1) plays an integral role in blood pressure control, and is implicated in the pathogenesis of hypertension...

More Information


  1. Godin C, Ferguson S. The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase. Mol Pharmacol. 2010;77:903-11 pubmed publisher
    ..Thus, we show that membrane blebbing in response to AT(1)R signaling is dependent on beta-arrestin2 and is mediated by a RhoA/ROCK/MLCK-dependent pathway. ..
  2. Mehri S, Mahjoub S, Finsterer J, Zaroui A, Mechmeche R, Baudin B, et al. The CC genotype of the angiotensin II type I receptor gene independently associates with acute myocardial infarction in a Tunisian population. J Renin Angiotensin Aldosterone Syst. 2011;12:595-600 pubmed publisher
    ..In conclusion, the ATR1 A1166C polymorphism is associated with AMI and the CC genotype associated with increased ACE activity and cTnI levels appear to predispose for AMI risk. ..
  3. van den Born B, van Montfrans G, Uitterlinden A, Zwinderman A, Koopmans R. The M235T polymorphism in the angiotensinogen gene is associated with the risk of malignant hypertension in white patients. J Hypertens. 2007;25:2227-33 pubmed
    ..AGT) M235T, angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II-type I receptor (AT1R) A1166C polymorphisms in malignant hypertensive patients with hypertensive and normotensive controls...
  4. Li H, Armando I, Yu P, Escano C, Mueller S, Asico L, et al. Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells. J Clin Invest. 2008;118:2180-9 pubmed publisher
    ..expression of both the antihypertensive dopamine 5 receptor (D5R) and the prohypertensive Ang II type 1 receptor (AT1R). In this report, we investigated the in vivo and in vitro interaction between these GPCRs...
  5. Sun Y, Liao Y, Yuan Y, Feng L, Ma S, Wei F, et al. Influence of autoantibodies against AT1 receptor and AGTR1 polymorphisms on candesartan-based antihypertensive regimen: results from the study of optimal treatment in hypertensive patients with anti-AT1-receptor autoantibodies trial. J Am Soc Hypertens. 2014;8:21-7 pubmed publisher
    ..Angiotensin II receptor gene (AGTR1) polymorphisms were associated with BP response to RAS inhibition in the hypertensive population...
  6. Garrido Gil P, Valenzuela R, Villar Cheda B, Lanciego J, Labandeira Garcia J. Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin-angiotensin system in the nigra. Brain Struct Funct. 2013;218:373-88 pubmed publisher
    ..The present results together with our previous findings in rodents suggest a major role for the nigral RAS in the normal functioning of the dopaminergic neurons, and in the progression of the dopaminergic degeneration. ..
  7. Pende A, Contini L, Sallo R, Passalacqua M, Tanveer R, Port J, et al. Characterization of RNA-binding proteins possibly involved in modulating human AT 1 receptor mRNA stability. Cell Biochem Funct. 2008;26:493-501 pubmed publisher
    ..Our findings allow identification of specific RNA-binding proteins possibly involved in the control of the hAT1-receptor mRNA stability and in the regulation of their expressions. ..
  8. Smilde T, Zuurman M, Hillege H, van Veldhuisen D, van Gilst W, van der Steege G, et al. Renal function dependent association of AGTR1 polymorphism (A1166C) and electrocardiographic left-ventricular hypertrophy. Am J Hypertens. 2007;20:1097-103 pubmed
    ..The following RAS polymorphisms were determined: angiotensin II type-1 receptor (AGTR1 A1166C), angiotensin-converting enzyme (ACE) insertion/deletion (I/D), and angiotensinogen (AGT G-6A)...
  9. Ceolotto G, Papparella I, Bortoluzzi A, Strapazzon G, Ragazzo F, Bratti P, et al. Interplay between miR-155, AT1R A1166C polymorphism, and AT1R expression in young untreated hypertensives. Am J Hypertens. 2011;24:241-6 pubmed publisher
    ..polymorphism) localized in the 3'-UTR (untranslated region) of the human angiotensin II type-1 receptor (AT1R) has been associated with hypertension and cardiovascular complications...
  10. Campbell C, Fang B, Guo X, Peralta C, Psaty B, Rich S, et al. Associations between genetic variants in the ACE, AGT, AGTR1 and AGTR2 genes and renal function in the Multi-ethnic Study of Atherosclerosis. Am J Nephrol. 2010;32:156-62 pubmed publisher
    ..that polymorphisms in angiotensin-converting enzyme (ACE), angiotensinogen (AGT), angiotensin II type I receptor (AGTR1) and angiotensin II type II receptor (AGTR2) genes may contribute to renal function variation...
  11. Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, et al. Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease. Liver Int. 2009;29:1078-85 pubmed publisher
    ..Recently an angiotensin II type 1 receptor (AGTR1) has been recognized as important in the aetiology of fibrosis in the liver...
  12. Palatini P, Ceolotto G, Dorigatti F, Mos L, Santonastaso M, Bratti P, et al. Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome. Am J Hypertens. 2009;22:208-14 pubmed publisher
    The aim of the study was to investigate the effect of polymorphism A1166C for AGTR1 and -1332G/A for AGTR2 on the incidence of sustained hypertension (HT) and metabolic syndrome in a cohort of young patients screened for stage 1 HT...
  13. Tanaka N, Miyajima A, Kosaka T, Shirotake S, Hasegawa M, Kikuchi E, et al. Cis-dichlorodiammineplatinum upregulates angiotensin II type 1 receptors through reactive oxygen species generation and enhances VEGF production in bladder cancer. Mol Cancer Ther. 2010;9:2982-92 pubmed publisher
    We previously reported that angiotensin II type 1 receptor (AT1R) antagonists enhanced the cytotoxity of cis-dichlorodiammineplatinum (CDDP) in a bladder cancer xenograft model...
  14. Jaffré F, Bonnin P, Callebert J, Debbabi H, Setola V, Doly S, et al. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ Res. 2009;104:113-23 pubmed publisher
    ..Accordingly, antagonists of 5-HT(2B) receptors might represent novel therapeutics for sympathetic overstimulation-dependent heart failure. ..
  15. Niu W, Qi Y. Association of the angiotensin II type I receptor gene +1166 A>C polymorphism with hypertension risk: evidence from a meta-analysis of 16474 subjects. Hypertens Res. 2010;33:1137-43 pubmed publisher
    ..suggests the potential susceptibility of individuals with a mutation in the angiotensin II type I receptor (AT1R) gene to hypertension...
  16. Ainscough J, Drinkhill M, Sedo A, Turner N, Brooke D, Balmforth A, et al. Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction. Cardiovasc Res. 2009;81:592-600 pubmed publisher
    ..expression of a wild-type or N111G mutant form of the human angiotensin II (Ang II) type-1 receptor (hAT1R) were generated. The wild-type receptor is primarily stimulated by Ang II...
  17. Jiang X, Sheng H, Li J, Xun P, Cheng Y, Huang J, et al. Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study. J Hum Hypertens. 2009;23:176-81 pubmed publisher
    ..enzyme (ACE) (I/D), angiotensinogen (AGT) (A-6G, A-20C, G-217A and T174 M) and angiotensin type 1 receptor (AT1R) (A1166C). Six polymorphisms were genotyped by gene chip technology...
  18. Ntzani E, Rizos E, Ioannidis J. Genetic effects versus bias for candidate polymorphisms in myocardial infarction: case study and overview of large-scale evidence. Am J Epidemiol. 2007;165:973-84 pubmed
    ..In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ..
  19. Li H, Ma Y, Fu Q, Wang L. Angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II type 1 receptor (AT1R) gene polymorphism and its association with preeclampsia in Chinese women. Hypertens Pregnancy. 2007;26:293-301 pubmed
    ..whether polymorphisms of angiotensin converting enzyme gene (ACE) and angiotensin II receptor type 1 gene (AT1R) are associated with etiology of preeclampsia and renal impact in women with preeclampsia...
  20. Turgut S, Akin F, Akcılar R, Ayada C, Turgut G. Angiotensin converting enzyme I/D, angiotensinogen M235T and AT1-R A/C1166 gene polymorphisms in patients with acromegaly. Mol Biol Rep. 2011;38:569-76 pubmed publisher
    ..The distribution of AT1R A/C1166 genotypes was significantly different between patients and control subjects (P=0.016)...
  21. Greco S, Elia M, Muscella A, Storelli C, Marsigliante S. AT1 angiotensin II receptor mediates intracellular calcium mobilization in normal and cancerous breast cells in primary culture. Cell Calcium. 2002;32:1-10 pubmed
    ..Type I Ang II receptor subtype (AT1) mediates Ang II-dependent [Ca2+]i increase, since losartan, an AT1 inhibitor, blunted [Ca2+]i increase induced by ..
  22. Seremak Mrozikiewicz A, Dubiel M, Drews K, Breborowicz G, Mrozikiewicz P. 1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia. J Matern Fetal Neonatal Med. 2005;17:117-21 pubmed
    To ascertain the frequency of polymorphic variants of the gene coding for angiotensin II type 1 receptor (AT1) and its correlation with umbilical artery (UA) blood flow velocity in a group of women with preeclampsia (PE)...
  23. Allen A, Moeller I, Jenkins T, Zhuo J, Aldred G, Chai S, et al. Angiotensin receptors in the nervous system. Brain Res Bull. 1998;47:17-28 pubmed
    ..Angiotensin AT1 and AT2 receptors occur in characteristic distributions that are highly correlated with the distribution of ..
  24. Matsusaka T, Ichikawa I. Biological functions of angiotensin and its receptors. Annu Rev Physiol. 1997;59:395-412 pubmed
    ..a stimulation of hormone synthesis and ion transport in the heart, kidney, and adrenal, primarily through type 1 (AT1) receptors...
  25. Agachan B, Isbir T, Yilmaz H, Akoglu E. Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients. Exp Mol Med. 2003;35:545-9 pubmed
    ..81%). Frequency of ATR1 C allele (AC+CC genotypes) was found higher hypertensives than controls (39.4% vs 25.9%; P = 0.054). Our results suggest that an interaction exists between the RAS genes and hypertension in Turkish population. ..
  26. Wei H, Ahn S, Barnes W, Lefkowitz R. Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. J Biol Chem. 2004;279:48255-61 pubmed
    ..These findings demonstrate how the ability of receptors to interact with beta-arrestins determines both the mechanism of ERK activation as well as the physiological consequences of this activation. ..
  27. Li X, Wang L, Han X. [Association between angiotensin system gene polymorphism and essential hypertension]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001;18:292-5 pubmed
    ..05). The ACE D allele and AGT 235T polymorphism may be involved in the early occurrence of HT. The combined genotypes of DD-TT and ID-TT may be a dangerous genetic factor for HT in Chinese. ..
  28. Buraczynska M, Ksiazek P, Zaluska W, Spasiewicz D, Nowicka T, Ksiazek A. Angiotensin II type 1 receptor gene polymorphism in end-stage renal disease. Nephron. 2002;92:51-5 pubmed
    ..We examined the A1166C polymorphism at the angiotensin II type 1 (AT1R) locus in patients with end-stage renal disease (ESRD)...
  29. Szolnoki Z, Havasi V, Talian G, Bene J, Komlosi K, Somogyvari F, et al. Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers. J Mol Neurosci. 2006;28:285-90 pubmed
    Recent observations revealed a novel role of angiotensin-converting enzyme 2 and the angiotensin II type-1 receptor (AT1R) in lung injury, thereby extending knowledge about the functions of the angiotensin system...
  30. Prasad P, Tiwari A, Kumar K, Ammini A, Gupta A, Gupta R, et al. Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms. BMC Med Genet. 2006;7:42 pubmed
    ..namely-renin (REN), angiotensinogen (ATG), angiotensin converting enzyme I (ACE), angiotensin II type 1 receptor (AT1) and aldosterone synthase (CYP11B2) gene from the RAAS pathway and one from chymase pathway were genotyped using ..
  31. Asselbergs F, Williams S, Hebert P, Coffey C, Hillege H, Navis G, et al. Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels. Genomics. 2007;89:362-9 pubmed
    ..system has been linked to the production of PAI-1 expression via the angiotensin II type 1 receptor (AT1R). In addition, bradykinin can induce the release of t-PA through a B2 receptor mechanism...
  32. Sugimoto K, Katsuya T, Ohkubo T, Hozawa A, Yamamoto K, Matsuo A, et al. Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study. Hypertens Res. 2004;27:551-6 pubmed
    Gene targeting approaches have suggested that the angiotensin II type 1 receptor (AT1R) is involved in blood pressure (BP) regulation and modulation of the effect of angiotensin II...
  33. Liu Y, Zhuoma C, Shan G, Cui C, Hou S, Qin W, et al. A1166C polymorphism of the angiotensin II type 1 receptor gene and essential hypertension in Han, Tibetan and Yi populations. Hypertens Res. 2002;25:515-21 pubmed
    ..substitution of cytosine for adenine at position 1166 (A1166C) polymorphism of the angiotensin II type 1 receptor (AT1R) gene is associated with susceptibility to essential hypertension in Han, Tibetan and Yi populations in China...
  34. Tabara Y, Kohara K, Miki T. Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. J Hypertens. 2002;20:651-6 pubmed
    ..78, 95% CI 1.06-3.00, P = 0.030) were independent risks for orthostatic hypotension. These findings indicate that genes encoding sympathetic nervous components could be involved in the predisposition for orthostatic hypotension. ..
  35. Buraczynska M, Ksiazek P, Łopatyński J, Spasiewicz D, Nowicka T, Ksiazek A. [Association of the renin-angiotensin system gene polymorphism with nephropathy in type II diabetes]. Pol Arch Med Wewn. 2002;108:725-30 pubmed
    ..enzyme gene (ACE), M235T of the angiotensinogen gene (AGT) and A1166C of the angiotensin II type 1 receptor gene (AT1R) were evaluated by polymerase chain reaction (PCR)...
  36. Andrikopoulos G, Tzeis S, Needham E, Richter D, Zairis M, Gialafos E, et al. Lack of association between common polymorphisms in genes of the renin-angiotensin system and mortality after myocardial infarction. Cardiology. 2005;103:185-8 pubmed
    The insertion/deletion (I/D) polymorphism in the ACE gene and the A1166C polymorphism in the AT1R gene have been associated with left ventricular remodelling and prognosis after acute myocardial infarction (AMI)...
  37. Hernández Ortega E, Medina Fernández Aceituno A, Rodríguez Esparragón F, Hernández Perera O, Melián Nuez F, Delgado Espinosa A, et al. [The involvement of the renin-angiotensin system gene polymorphisms in coronary heart disease]. Rev Esp Cardiol. 2002;55:92-9 pubmed
    ..enzyme gene insertion/deletion polymorphism ACE (I/D), angiotensinogen gene polymorphism, and angiotensin II AT1 receptor polymorphism in relation to coronary heart disease controversial results...
  38. Kurland L, Melhus H, Karlsson J, Kahan T, Malmqvist K, Ohman K, et al. Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients. J Hypertens. 2001;19:1783-7 pubmed
    ..ACE genotyping predicted the blood pressure-lowering response to antihypertensive treatment with irbesartan but not atenolol. Thus, specific genotypes might predict the response to specific antihypertensive treatment. ..
  39. Guo D, Furuta H, Mizukoshi M, Inagami T. The genomic organization of human angiotensin II type 1 receptor. Biochem Biophys Res Commun. 1994;200:313-9 pubmed
    ..step toward the elucidation of human Ang II type 1 receptor gene expression, the genomic organization of the human AT1 receptor was investigated...
  40. Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, et al. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension. 1994;24:63-9 pubmed
    We conducted the present study to determine whether the angiotensin II type I receptor (AT1) gene might be implicated in human essential hypertension by using case-control and linkage studies...
  41. Coto E, Rodrigo L, Alvarez R, Fuentes D, Rodriguez M, Menéndez L, et al. Variation at the Angiotensin-converting enzyme and endothelial nitric oxide synthase genes is associated with the risk of esophageal varices among patients with alcoholic cirrhosis. J Cardiovasc Pharmacol. 2001;38:833-9 pubmed
    ..the angiotensinogen (AGT), the angiotensin-converting enzyme (ACE), and the angiotensin II receptor type 1 (AT1R) are polymorphic, and these polymorphisms have been associated with several cardiovascular diseases...
  42. Coll E, Campos B, Gonzalez Nunez D, Botey A, Poch E. Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency. J Nephrol. 2003;16:357-64 pubmed
    ..AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and ..
  43. Ranjith N, Pegoraro R, Rom L, Lanning P, Naidoo D. Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians. Cardiovasc J S Afr. 2004;15:22-6 pubmed genetic components of this system, such as the angiotensin-converting enzyme (ACE) gene, angiotensin II type 1 (AT1) receptor gene and angiotensinogen (AGT) gene, may cause a variety of adverse cardiovascular effects...
  44. Marrero M, Schieffer B, Paxton W, Heerdt L, Berk B, Delafontaine P, et al. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature. 1995;375:247-50 pubmed
    ..and adrenal aldosterone release, are mediated through a single class of cell-surface receptors known as AT1 (refs 1, 2). These receptors contain the structural features of the G-protein-coupled receptor superfamily...
  45. Oakley R, Laporte S, Holt J, Barak L, Caron M. Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. J Biol Chem. 2001;276:19452-60 pubmed
  46. Zhang X, Wang D, Xu L, Ma Y, Zhang S. [Association between renin-angiotensin system gene polymorphism and type 2 diabetics with stroke in China]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001;18:462-6 pubmed
    ..Angiotensin 1-converting enzyme (ACE) genotypes and type 1 angiotensin II receptor(AT1R) genotypes were investigated with PCR and PCR/DdeI enzyme digesting techniques in 152 cases of ..
  47. Roberts C, Rom L, Moodley J, Pegoraro R. Hypertension-related gene polymorphisms in pre-eclampsia, eclampsia and gestational hypertension in Black South African women. J Hypertens. 2004;22:945-8 pubmed
    ..049; odds ratio 0.36 [95% confidence interval (CI) 0.09-1.04]). The commonly occurring RAS polymorphisms are not predictive of pre-eclampsia or eclampsia in the Black South African population. ..
  48. Venema R, Ju H, Venema V, Schieffer B, Harp J, Ling B, et al. Angiotensin II-induced association of phospholipase Cgamma1 with the G-protein-coupled AT1 receptor. J Biol Chem. 1998;273:7703-8 pubmed
    An early event in signaling by the G-protein-coupled angiotensin II (Ang II) AT1 receptor in vascular smooth muscle cells is the tyrosine phosphorylation and activation of phospholipase Cgamma1 (PLCgamma1)...
  49. Hunton D, Barnes W, Kim J, Ren X, Violin J, Reiter E, et al. Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol Pharmacol. 2005;67:1229-36 pubmed
    ..These data suggest that beta-arrestin 2 can mediate chemotaxis through mechanisms which may be G-protein-independent (Ang II receptors) or -dependent (LPA receptors). ..
  50. Luttrell L, Roudabush F, Choy E, Miller W, Field M, Pierce K, et al. Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci U S A. 2001;98:2449-54 pubmed
    ..of extracellular signal-regulated kinase 2 (ERK2) following stimulation of angiotensin II type 1a receptors (AT1aR)...
  51. Konoshita T, Miyagi K, Onoe T, Katano K, Mutoh H, Nomura H, et al. Effect of ACE gene polymorphism on age at renal death in polycystic kidney disease in Japan. Am J Kidney Dis. 2001;37:113-118 pubmed, ACE insertion/deletion (I/D) polymorphism, angiotensinogen (AGT) M235T, and angiotensin II type 1 receptor (AT1) A1166C. Seventy-six of the 103 patients (73.8%) reached ESRD at an average age of 52.1 +/- 11.3 years...
  52. Henskens L, Kroon A, van Boxtel M, Hofman P, de Leeuw P. Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension. Stroke. 2005;36:1869-73 pubmed
    ..M235T), the angiotensin-converting enzyme (insertion/deletion [I/D]), the angiotensin II type 1 receptor (AGTR1 A1166C), and the NOS3 (G894T) genes...
  53. Jiang Z, Zhao W, Yu F, Xu G. Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Chin Med J (Engl). 2001;114:1249-51 pubmed
    To determine whether the polymorphism A1166C in the angiotensin II type 1 receptor (AT1R) gene is associated with essential hypertension. A case-control study was carried out using 125 hypertensive and 103 normotensive subjects...
  54. Hindorff L, Heckbert S, Tracy R, Tang Z, Psaty B, Edwards K, et al. Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events. Am J Hypertens. 2002;15:1050-6 pubmed
    ..On the whole, in this large cohort of older adults, the A1166C polymorphism was not associated with BP control or incident cardiovascular events. The subgroup findings in treated hypertensives need to be confirmed in additional studies. ..
  55. Kurland L, Melhus H, Karlsson J, Kahan T, Malmqvist K, Ohman P, et al. Polymorphisms in the angiotensinogen and angiotensin II type 1 receptor gene are related to change in left ventricular mass during antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Ateno. J Hypertens. 2002;20:657-63 pubmed
    ..LVH were included in a double-blind study to receive treatment with either the angiotensin II type 1 receptor (AT1-receptor) antagonist irbesartan (n = 41), or the beta-1 adrenergic receptor blocker atenolol (n = 43) as ..
  56. Lim H, Cho J, Oh D, Chung J, Hong K, Bae K, et al. Angiotensin II type 1 receptor 1166A/C polymorphism in association with blood pressure response to exogenous angiotensin II. Eur J Clin Pharmacol. 2007;63:17-26 pubmed
    The angiotensin II type 1 receptor (AT1R) 1166A/C polymorphism is reported to be implicated in cardiovascular diseases...
  57. Jones A, Dhamrait S, Payne J, Hawe E, Li P, Toor I, et al. Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension. Hypertension. 2003;42:500-6 pubmed
    ..pathogenesis through a balance of actions of angiotensin II on (potentially proatherogenic) constitutive type 1 (AT1R) and (potentially antiatherogenic) inducible type 2 (AT2R) receptors...
  58. Abdollahi M, Lewis R, Gaunt T, Cumming D, Rodriguez S, Rose Zerilli M, et al. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Hum Mutat. 2007;28:365-73 pubmed
    The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance...
  59. Redon J, Luque Otero M, Martell N, Chaves F. Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients. Pharmacogenomics J. 2005;5:14-20 pubmed
    ..The results indicate that these RAS gene polymorphisms do not affect the antihypertensive activity and renoprotection in mild-to-moderate hypertensive patients treated with telmisartan. ..
  60. Barnes W, Reiter E, Violin J, Ren X, Milligan G, Lefkowitz R. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem. 2005;280:8041-50 pubmed
  61. Kee F, Morrison C, Poirier O, McCrum E, Mallet C, Nicaud V, et al. Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women. Eur J Clin Invest. 2000;30:1076-82 pubmed
    ..While other loci, such as the angiotensin II type-I receptor (AT1R), may modulate risk, few studies have adequately documented the risk in women...
  62. Buraczynska M, Pijanowski Z, Spasiewicz D, Nowicka T, Sodolski T, Widomska Czekajska T, et al. Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. Kardiol Pol. 2003;58:1-9 pubmed
    ..Angiotensinconverting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene polymorphisms are considered risk factors in coronary heart disease (CHD)...
  63. Ulgen M, Ozturk O, Yazici M, Kayrak M, Alan S, Koc F, et al. Association between A/C1166 gene polymorphism of the angiotensin II type 1 receptor and biventricular functions in patients with acute myocardial infarction. Circ J. 2006;70:1275-9 pubmed
    Although there have been several association studies of angiotensin II type 1 receptor (AT1R, A/C1166) gene polymorphism in clinical endpoints such as myocardial infarction (MI), hypertension, aortic stiffness, and left ventricular mass, ..
  64. Hsu C, Bray M, Kao W, Pankow J, Boerwinkle E, Coresh J. Genetic variation of the renin-angiotensin system and chronic kidney disease progression in black individuals in the atherosclerosis risk in communities study. J Am Soc Nephrol. 2006;17:504-12 pubmed
    ..In white individuals, the A1166C 3'-UTR variant of angiotensin II type 1 receptor (AT1R) has been associated with CKD. CKD associations with these RAS genes are uncertain in high-risk black populations...
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    ..This discovery emphasizes the role of the cell surface in angiotensin II generation and opens new perspectives on the tissue renin-angiotensin system and on renin effects independent of angiotensin II. ..
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    ..The BP response to high salt intake was different among genotypes of ACE I/D and 11betaHSD G534A, suggesting that these polymorphisms may be potentially useful genetic markers of salt sensitivity. ..
  67. Reich H, Duncan J, Weinstein J, Cattran D, Scholey J, Miller J. Interactions between gender and the angiotensin type 1 receptor gene polymorphism. Kidney Int. 2003;63:1443-9 pubmed
    ..In addition, the renal hemodynamic response to angiotensin II infusion is a function of both gender and the AGT1R genotype. ..
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    ..inhibitors (ACEIs), single-nucleotide polymorphisms (SNPs) in the angiotensinogen (AGT), angiotensin receptor 1 (AGTR1), and angiotensin receptor 2 (AGTR2) genes were evaluated for their association with BP response to ACEI in ..
  69. Kikuya M, Sugimoto K, Katsuya T, Suzuki M, Sato T, Funahashi J, et al. A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study. Hypertens Res. 2003;26:141-5 pubmed
    ..A/C1166 gene polymorphism in the 3' untranslated region of the angiotensin II type 1 receptor (AT1) gene is the final remaining major target in R-A-A to be examined in the Ohasama Study population...
  70. Fabris B, Bortoletto M, Candido R, Barbone F, Cattin M, Calci M, et al. Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension. J Hypertens. 2005;23:309-16 pubmed
    ..of angiotensin-converting enzyme (ACE I/D), angiotensinogen (AGT) M235T, angiotensin II type 1 receptor (AT1R) A1166C and aldosterone synthase (CYP11B2) -344C/T polymorphisms were performed using polymerase chain reaction, ..
  71. Fradin S, Goulet Salmon B, Chantepie M, Grandhomme F, Morello R, Jauzac P, et al. Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients. Diabetes Metab. 2002;28:27-32 pubmed
    ..The A1166C AT1R polymorphism is involved in arterial hypertension and in diabetic retinopathy...
  72. Rubattu S, Di Angelantonio E, Stanzione R, Zanda B, Evangelista A, Pirisi A, et al. Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant. J Hypertens. 2004;22:2129-34 pubmed
    ..was performed in the whole population and, based on a significant interaction between angiotensin II receptor (AT1) genotype and hypertension, was also repeated in the hypertensive subgroup...
  73. Abdollahi M, Gaunt T, Syddall H, Cooper C, Phillips D, Ye S, et al. Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits. J Med Genet. 2005;42:396-401 pubmed
    ..Angiotensin II type I receptor (AGTR1) A1166C has previously been associated with the development of hypertension and coronary disease, but its ..
  74. Qian H, Pipolo L, Thomas W. Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization. Mol Endocrinol. 2001;15:1706-19 pubmed
  75. Bouba I, Makrydimas G, Kalaitzidis R, Lolis D, Siamopoulos K, Georgiou I. Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2003;110:8-11 pubmed
    ..angiotensin-converting enzyme gene (ACE) and the A1166C polymorphism of the angiotensin II type 1 receptor gene (AT1R) by PCR. Allele and genotype frequencies of the AGT gene polymorphism differed between the two study groups...