AGTR1

Summary

Gene Symbol: AGTR1
Description: angiotensin II receptor, type 1
Alias: AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1AR, AT1BR, angiotensin II type-1 receptor, angiotensin receptor 1, angiotensin receptor 1B, type-1 angiotensin II receptor, type-1B angiotensin II receptor
Species: human

Top Publications

  1. ncbi Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation
    Noritaka Yasuda
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    EMBO Rep 9:179-86. 2008
  2. ncbi Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women
    Silvana Aparecida Alves Correa
    Molecular Gynaecology Laboratory, Department of Gynaecology, Federal University of Sao Paulo, Rua Pedro de Toledo, 781 4th Floor, Sao Paulo, 04039 032 SP, Brazil
    J Renin Angiotensin Aldosterone Syst 10:51-8. 2009
  3. ncbi Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population
    J A Schoenhard
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Hum Genet 124:479-88. 2008
  4. ncbi Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study
    X Jiang
    Department of Geriatrics, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
    J Hum Hypertens 23:176-81. 2009
  5. ncbi Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension
    A Bonnardeaux
    INSERM U36, College de France, Paris
    Hypertension 24:63-9. 1994
  6. ncbi Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients
    J Redon
    Hypertension Clinic, Hospital Clinico, University of Valencia, Spain
    Pharmacogenomics J 5:14-20. 2005
  7. ncbi Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
  8. ncbi Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome
    Paolo Palatini
    Dipartimento di Medicina Clinica e Sperimentale, Clinica Medica 4, University of Padova, Padova, Italy
    Am J Hypertens 22:208-14. 2009
  9. ncbi The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activation
    Ivana Domazet
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 284:11922-9. 2009
  10. ncbi Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension
    Léon H G Henskens
    Department of Internal Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Stroke 36:1869-73. 2005

Research Grants

  1. MOLECULAR BASIS FOR ANGIOTENSIN II RECEPTOR FUNCTION(S)
    Sadashiva Karnik; Fiscal Year: 2005
  2. Renal Angiotensin II Receptor Function in Obesity
    Tahir Hussain; Fiscal Year: 2009
  3. Renal Angiotensin II Receptor Function in Obesity
    Tahir Hussain; Fiscal Year: 2010
  4. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    Robert Wayne Alexander; Fiscal Year: 2010
  5. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    R Alexander; Fiscal Year: 2007
  6. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    R Alexander; Fiscal Year: 2009
  7. Central actions of angiotensin II in the control of fluid balance
    LORI MARIE FLANAGAN CATO; Fiscal Year: 2011
  8. Central actions of angiotensin II in the control of fluid balance
    DANIEL K contact YEE; Fiscal Year: 2010
  9. Central actions of angiotensin II in the control of fluid balance
    Daniel Yee; Fiscal Year: 2009
  10. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2009

Detail Information

Publications241 found, 100 shown here

  1. ncbi Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation
    Noritaka Yasuda
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    EMBO Rep 9:179-86. 2008
    ..Our results show that the AT(1) receptor undergoes a conformational switch that couples mechanical stress-induced activation and inverse agonist-induced inactivation...
  2. ncbi Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women
    Silvana Aparecida Alves Correa
    Molecular Gynaecology Laboratory, Department of Gynaecology, Federal University of Sao Paulo, Rua Pedro de Toledo, 781 4th Floor, Sao Paulo, 04039 032 SP, Brazil
    J Renin Angiotensin Aldosterone Syst 10:51-8. 2009
    ....
  3. ncbi Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population
    J A Schoenhard
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Hum Genet 124:479-88. 2008
    ....
  4. ncbi Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study
    X Jiang
    Department of Geriatrics, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
    J Hum Hypertens 23:176-81. 2009
    ..enzyme (ACE) (I/D), angiotensinogen (AGT) (A-6G, A-20C, G-217A and T174 M) and angiotensin type 1 receptor (AT1R) (A1166C). Six polymorphisms were genotyped by gene chip technology...
  5. ncbi Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension
    A Bonnardeaux
    INSERM U36, College de France, Paris
    Hypertension 24:63-9. 1994
    We conducted the present study to determine whether the angiotensin II type I receptor (AT1) gene might be implicated in human essential hypertension by using case-control and linkage studies...
  6. ncbi Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients
    J Redon
    Hypertension Clinic, Hospital Clinico, University of Valencia, Spain
    Pharmacogenomics J 5:14-20. 2005
    ..enzyme insertion/deletion polymorphism, and the A1166C and C573T polymorphisms of the angiotensin II type 1 receptor gene...
  7. ncbi Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
    ..of the renin-angiotensin system has been linked to the production of PAI-1 expression via the angiotensin II type 1 receptor (AT1R). In addition, bradykinin can induce the release of t-PA through a B2 receptor mechanism...
  8. ncbi Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome
    Paolo Palatini
    Dipartimento di Medicina Clinica e Sperimentale, Clinica Medica 4, University of Padova, Padova, Italy
    Am J Hypertens 22:208-14. 2009
    The aim of the study was to investigate the effect of polymorphism A1166C for AGTR1 and -1332G/A for AGTR2 on the incidence of sustained hypertension (HT) and metabolic syndrome in a cohort of young patients screened for stage 1 HT.
  9. ncbi The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activation
    Ivana Domazet
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 284:11922-9. 2009
    ..Our results suggest that constitutive activation of the AT(1) receptor causes TMD2 to pivot, bringing the top of TMD2 closer to the binding pocket and pushing the bottom of TMD2 away from the binding pocket...
  10. ncbi Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension
    Léon H G Henskens
    Department of Internal Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Stroke 36:1869-73. 2005
    ..Because these lesions may have a genetic background, we assessed the associations between polymorphisms of the renin-angiotensin system and the endothelial NO synthase (NOS3) genes and silent WMLs...
  11. ncbi Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension
    Wendy K Chung
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Heart Lung Transplant 28:373-9. 2009
    ..The renin angiotensin aldosterone system (RAAS) provides a set of candidate genes that could modulate pulmonary vascular disease similar to its effects on renal and peripheral vasculature...
  12. ncbi Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor
    John Huynh
    School of Biomedical Sciences, The University of Queensland, Brisbane, St Lucia, Queensland, Australia
    Mol Cell Endocrinol 302:118-27. 2009
    ..The type 1 angiotensin II receptor is a widely studied GPCR with roles in blood pressure regulation,water and salt balance and cell ..
  13. ncbi Adenine/cytosine(1166) polymorphism of the angiotensin II type 1 receptor gene and the antihypertensive response to angiotensin-converting enzyme inhibitors
    Huimin Yu
    Department of Cardiology, Guangdong General Hospital and Guangdong Cardiovascular Institute, Guangzhou, China
    J Hypertens 27:2278-82. 2009
    Most of the known actions of angiotensin II are mediated by the angiotensin II type 1 receptor (AGT1R)...
  14. ncbi Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes
    Ulrik Pedersen-Bjergaard
    Endocrinology Section, Division of Internal Medicine I, Hillerød Hospital, Hillerød, Denmark
    Am J Med 121:246.e1-8. 2008
    ..We explored whether genetic and phenotypic variations in other components of the renin-angiotensin system are similarly associated...
  15. ncbi Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients
    L Kurland
    Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
    J Hypertens 19:1783-7. 2001
    ..To determine whether polymorphisms in the renin-angiotensin system can predict blood pressure-lowering response to antihypertensive treatment; more specifically, in response to treatment with irbesartan or atenolol...
  16. ncbi Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts
    Gregory T Jones
    Department of Surgery, University of Otago, New Zealand
    Arterioscler Thromb Vasc Biol 28:764-70. 2008
    ..This study was undertaken, using the largest case series yet reported, to determine whether common genetic variants of the RAS are associated with either susceptibility or severity of AAA...
  17. ncbi Polymorphisms in angiotensin II type 1 receptor and angiotensin I-converting enzyme genes and breast cancer risk among Chinese women in Singapore
    Woon Puay Koh
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, Singapore 117597, Singapore
    Carcinogenesis 26:459-64. 2005
    ..has been shown to mediate growth in breast cancer cell lines via ligand-induced activity through the angiotensin II type 1 receptor (AGTR1)...
  18. ncbi Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model
    Noriyuki Hiramatsu
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Am Soc Nephrol 18:515-27. 2007
    ..proteinuria, and subsequent glomerulosclerosis by heminephrectomy was almost completely inhibited by angiotensin II type 1 receptor (AT1R) blocker olmesartan...
  19. ncbi Hypertension-related gene polymorphisms in pre-eclampsia, eclampsia and gestational hypertension in Black South African women
    Candice B Roberts
    Departments of Obstetrics and Gynaecology, MRC UN Pregnancy Hypertension Research Unit, Nelson R Mandela School of Medicine, University of Natal, Private Bag 7, Congella, 4013 Durban, South Africa
    J Hypertens 22:945-8. 2004
    ..To examine whether polymorphisms in the renin-angiotensin system (RAS) are associated with pregnancy-related hypertensive disorders in a black South African population...
  20. ncbi A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene
    Gen Kobashi
    Division of Preventive Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060 8638, Japan
    J Hum Genet 49:182-6. 2004
    ..The aim of this study was to assess the association between the A1166C variant of the angiotensin II type 1 receptor (AT1) gene and severe HP...
  21. ncbi Synergistic effect of renin-angiotensin system and nitric oxide synthase genes polymorphisms in pre-eclampsia
    Chiara Benedetto
    Department of Obstetrics and Gynecology, University of Torino, Torino, Italy
    Acta Obstet Gynecol Scand 86:678-82. 2007
    ..The aim of this study was to assess if interactions among different polymorphisms of the renin-angiotensin system and nitric oxide synthase are involved in the pathogenesis of pre-eclampsia...
  22. ncbi Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia
    Ioanna Bouba
    Genetics Unit, Department of Obstetrics and Gynecology, Medical School, University of Ioannina, 45500, Ioannina, Greece
    Eur J Obstet Gynecol Reprod Biol 110:8-11. 2003
    ..I/D) polymorphism of the angiotensin-converting enzyme gene (ACE) and the A1166C polymorphism of the angiotensin II type 1 receptor gene (AT1R) by PCR...
  23. ncbi Angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II type 1 receptor (AT1R) gene polymorphism and its association with preeclampsia in Chinese women
    Hua Li
    Qilu Hospital, Shandong University, Jinan, China
    Hypertens Pregnancy 26:293-301. 2007
    To investigate whether polymorphisms of angiotensin converting enzyme gene (ACE) and angiotensin II receptor type 1 gene (AT1R) are associated with etiology of preeclampsia and renal impact in women with preeclampsia.
  24. ncbi 1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia
    Agnieszka Seremak-Mrozikiewicz
    Department of Perinatology and Gynecology, University School of Medical Sciences, Poznan, Poland
    J Matern Fetal Neonatal Med 17:117-21. 2005
    To ascertain the frequency of polymorphic variants of the gene coding for angiotensin II type 1 receptor (AT1) and its correlation with umbilical artery (UA) blood flow velocity in a group of women with preeclampsia (PE).
  25. ncbi Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 15:1050-6. 2002
    The angiotensin II type 1 receptor A1166C polymorphism has been associated with increased risks of hypertension and myocardial infarction in several small studies...
  26. ncbi Angiotensin-converting enzyme insertion/deletion and angiotensin type 1 receptor A1166C polymorphisms as genetic risk factors in benign prostatic hyperplasia and prostate cancer
    Erick Sierra Díaz
    Hospital de Especialidades, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social, Mexico
    J Renin Angiotensin Aldosterone Syst 10:241-6. 2009
    ....
  27. ncbi No association between variants in the ACE and angiotensin II receptor 1 genes and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 m
    Michael S Koehle
    Allan McGavin Sport Medicine Centre, Department of Family Practice, University of British Columbia, Vancouver, Canada
    High Alt Med Biol 7:281-9. 2006
    ..loci in the genes encoding angiotensin converting enzyme (ACE) and angiotensin II receptor type 1 gene (AGTR1)...
  28. ncbi miR-802 regulates human angiotensin II type 1 receptor expression in intestinal epithelial C2BBe1 cells
    Sarah E Sansom
    Davis Heart and Lung Research Institute, Department of Pathology, The Ohio State Univ, Columbus, 43210, USA
    Am J Physiol Gastrointest Liver Physiol 299:G632-42. 2010
    ..These results suggest that miR-802 can modulate the expression of the hAT(1)R in the GI tract and ultimately play a role in regulating the biological efficacy of Ang II in this system...
  29. ncbi Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor
    R Takayanagi
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 183:910-6. 1992
    ..The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis...
  30. ncbi Left ventricular size, mass and function in relation to angiotensin-converting enzyme gene and angiotensin-II type 1 receptor gene polymorphisms in patients with coronary artery disease
    Marcin Gruchala
    First Department of Cardiology Medical University of Gdansk, Gdansk, Poland
    Clin Chem Lab Med 41:522-8. 2003
    ..enzyme gene (I/D ACE) and the A1166C polymorphism of the angiotensin-II type 1 receptor gene polymorphisms (A1166C AT1R) on the left ventricular size and performance...
  31. ncbi ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin
    Marie Eve Poupart
    Department of Pharmacology, School of Medicine, University of Montreal, Montreal, QC, Canada
    Cell Signal 19:2370-8. 2007
    ..Here, we propose to elucidate the molecular steps controlled by ARF6 in the endocytic process of the angiotensin II type 1 receptor (ATR), a model receptor being internalized via the clathrin-coated vesicle pathway...
  32. ncbi Angiotensin II type 1 receptor expression on human leukocyte subsets: a flow cytometric and RT-PCR study
    Emanuela Rasini
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Regul Pept 134:69-74. 2006
    ..system plays a key role in the regulation of cardiovascular functions and in particular angiotensin II type 1 receptor (AT1R)-operated pathways are involved in the modulation of inflammation in the vascular wall...
  33. ncbi A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling
    Patrice C Leclerc
    Department of Pharmacology, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Endocrinology 143:4702-10. 2002
    ....
  34. ncbi The M235T polymorphism in the angiotensinogen gene is associated with the risk of malignant hypertension in white patients
    Bert Jan H van den Born
    Department of Internal and Vascular Medicine, Academic Medical Centre, Amsterdam The Netherlands
    J Hypertens 25:2227-33. 2007
    ..of the angiotensinogen (AGT) M235T, angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II-type I receptor (AT1R) A1166C polymorphisms in malignant hypertensive patients with hypertensive and normotensive controls.
  35. ncbi Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling
    Rathai Anandanadesan
    Department of Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA, USA
    J Gastrointest Surg 12:57-66. 2008
    ..We have recently shown that high levels of angiotensin II (AngII) type 1 receptor (AT1R) correlate and colocalize with VEGF in invasive PDA and that AngII induces VEGF expression in PDA cell lines...
  36. ncbi Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin Buch and Experimental and Clinical Research Center, Berlin, Germany
    Hypertension 53:393-8. 2009
    We showed earlier that activating autoantibodies against the angiotensin II type 1 (AT(1)) receptor (AT1-AA) circulate in preeclamptic women. They may be involved in the pathogenesis of preeclampsia...
  37. ncbi Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma
    Daniel Walcher
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Hypertension 51:259-66. 2008
    ..Telmisartan is an angiotensin type 1 receptor (AT1R) blocker with peroxisome proliferator-activated receptor (PPAR)-gamma-activating properties...
  38. ncbi Variation at the Angiotensin-converting enzyme and endothelial nitric oxide synthase genes is associated with the risk of esophageal varices among patients with alcoholic cirrhosis
    E Coto
    Molecular Genetics IRSIN and Digestive Service, Central Hospital of Asturias, Oviedo, Spain
    J Cardiovasc Pharmacol 38:833-9. 2001
    ..the angiotensinogen (AGT), the angiotensin-converting enzyme (ACE), and the angiotensin II receptor type 1 (AT1R) are polymorphic, and these polymorphisms have been associated with several cardiovascular diseases...
  39. ncbi Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization
    H Qian
    Molecular Endocrinology Laboratory, Baker Medical Research Institute, Melbourne 8008, Australia
    Mol Endocrinol 15:1706-19. 2001
    ....
  40. ncbi Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease
    G R Bullock
    Department of Pathology, Blok A 503, University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Histochem Cell Biol 115:117-24. 2001
    This study was designed to examine the cellular distribution of the angiotensin II type-1 (AT1) and type-2 (AT2) receptors in the normal human and pathological human lung...
  41. ncbi Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*
    R H Oakley
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:19452-60. 2001
    ....
  42. ncbi Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus
    Patricia H Gallego
    Department of Pediatric Endocrinology and Diabetes, Princess Margaret Hospital, Perth, WA, Australia
    J Diabetes Complications 22:191-8. 2008
    ..enzyme (ACE) insertion/deletion (I/D) for angiotensinogen (AGT) M235T and angiotensin II receptor type 1 (AGTR1) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM)...
  43. ncbi The human angiotensin AT(1) receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation
    Jakob Lerche Hansen
    Laboratory for Molecular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Eur J Pharmacol 590:255-63. 2008
    ..The realization of G protein-independent signalling by the human angiotensin AT(1) receptor has clear pharmacological implications for development of drugs with pathway-specific actions and defined biological outcomes...
  44. ncbi Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women
    F Kee
    Queen s University of Belfast, Belfast, Northern Ireland, UK
    Eur J Clin Invest 30:1076-82. 2000
    ..While other loci, such as the angiotensin II type-I receptor (AT1R), may modulate risk, few studies have adequately documented the risk in women...
  45. ncbi Renal function dependent association of AGTR1 polymorphism (A1166C) and electrocardiographic left-ventricular hypertrophy
    Tom D J Smilde
    Thorax Center, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Hypertens 20:1097-103. 2007
    ..We studied whether renal function modulates the association between RAS polymorphisms and LVH in a cross-sectional study of 8592 inhabitants of Groningen...
  46. ncbi Translation of the human angiotensin II type 1 receptor mRNA is mediated by a highly efficient internal ribosome entry site
    Mickey M Martin
    Department of Chemistry and Biochemistry, Brigham Young University, C211 BNSN, P O Box 25700, Provo, UT 84602 5700, USA
    Mol Cell Endocrinol 212:51-61. 2003
    Activation of the angiotensin II type 1 receptor (AT1R) is closely involved in the pathogenesis of cardiovascular disease...
  47. ncbi Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors
    Yasushi Kawaguchi
    Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Arthritis Rheum 50:216-26. 2004
    ....
  48. ncbi Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients
    Bedia Agachan
    University of Istanbul, Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul, Turkey
    Exp Mol Med 35:545-9. 2003
    ..gene polymorphisms, the angiotensin converting enzyme (ACE), angiotensinogen (AGN) M235T/T174M and angiotensin II type 1 receptor A1166C polymorphism in 109 hypertensive and 86 normotensive Turkish subjects...
  49. ncbi beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation
    William G Barnes
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:8041-50. 2005
    ....
  50. ncbi Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure
    Vicky A Cameron
    Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Hypertension 47:1155-61. 2006
    ..Studies in vascular cells and experimental animals have demonstrated that the angiotensin type-1 receptor (AT1R) contributes to formation of reactive oxygen species by activating nicotinamide-adenine dinucleotide phosphate ..
  51. ncbi Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms
    Pushplata Prasad
    Department of Genetics, University of Delhi South Campus, New Delhi, India
    BMC Med Genet 7:42. 2006
    ..We investigated the contribution of selected RAAS gene polymorphisms to CRI among type 2 diabetic Asian Indian subjects...
  52. ncbi Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival
    K Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Br J Cancer 94:552-60. 2006
    ..that angiotensin II enhanced tumour cell invasion and vascular endothelial growth factor (VEGF) secretion via AT1R in ovarian cancer cell lines in vitro...
  53. ncbi Genetic variation of the renin-angiotensin system and chronic kidney disease progression in black individuals in the atherosclerosis risk in communities study
    Charles Chia Chuen Hsu
    Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 17:504-12. 2006
    ..In white individuals, the A1166C 3'-UTR variant of angiotensin II type 1 receptor (AT1R) has been associated with CKD...
  54. ncbi Biological functions of angiotensin and its receptors
    T Matsusaka
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Annu Rev Physiol 59:395-412. 1997
    ..a stimulation of hormone synthesis and ion transport in the heart, kidney, and adrenal, primarily through type 1 (AT1) receptors...
  55. ncbi Coexistence of angiotensin II type-1 receptor A1166C and angiotensin-converting enzyme D/D polymorphism suggests susceptibility for small-vessel-associated ischemic stroke
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Neuromolecular Med 8:353-60. 2006
    ..Angiotensin II, which binds the angiotensin II type-1 receptor (AT1R), is a potent vasoconstrictor...
  56. ncbi Ischemic heart disease down-regulates angiotensin type 1 receptor mRNA in human coronary arteries
    Angelica Wackenfors
    Department of Internal Medicine, Division of Experimental Vascular Research, Lund University Hospital, BMC A13, SE 221 84 Lund, Sweden
    Eur J Pharmacol 503:147-53. 2004
    ..The angiotensin type 1 (AT1) receptor mRNA levels were down-regulated in human coronary arteries from patients with ischemic heart disease as ..
  57. ncbi Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study
    Ken Sugimoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 27:551-6. 2004
    Gene targeting approaches have suggested that the angiotensin II type 1 receptor (AT1R) is involved in blood pressure (BP) regulation and modulation of the effect of angiotensin II...
  58. ncbi Polymorphisms of the angiotensin converting enzyme and angiotensin II type 1 receptor genes and renal scarring in non-uropathic children with recurrent urinary tract infection
    Aydin Ece
    Department of Pediatrics, Pediatric Nephrology Unit, Dicie University, Diyarbakir, Turkey
    Nephrology (Carlton) 10:377-81. 2005
    The aim of this study was to investigate whether the angiotensin converting enzyme (ACE) and angiotensin II type 1 receptor (A1166C) gene polymorphisms were associated with the renal scar formation secondary to recurrent urinary tract ..
  59. ncbi Genetic effects versus bias for candidate polymorphisms in myocardial infarction: case study and overview of large-scale evidence
    Evangelia E Ntzani
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 165:973-84. 2007
    ..In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ..
  60. ncbi Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease
    Monika Buraczynska
    Chair and Department of Nephrology, Medical Academy, Lublin, Poland
    Kardiol Pol 58:1-9. 2003
    ..Angiotensinconverting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene polymorphisms are considered risk factors in coronary heart disease (CHD).
  61. ncbi Recurrent in-stent restenosis is not associated with the angiotensin-converting enzyme D/I, angiotensinogen Thr174Met and Met235Thr, and the angiotensin-II receptor 1 A1166C polymorphism
    C Michael Gross
    Franz Volhard Klinik, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invasive Cardiol 19:261-4. 2007
    ..enzyme (ACE) D/I, the angiotensinogen (AGT) T174M and M235T, and A1166C of the angiotensin-II receptor 1 (AGTR1), revealed that the incidence RISR in the high-risk cohort was not associated with any of the polymorphisms ..
  62. ncbi TGF-beta(1) regulation of human AT(1) receptor mRNA splice variants harboring exon 2
    Mickey M Martin
    College of Pharmacy, Division of Pharmacology, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Endocrinol 249:21-31. 2006
    ....
  63. ncbi Rationale for the chemical development of angiotensin II receptor antagonists
    R R Wexler
    Du Pont Merck Pharmaceutical Company, Wilmington, DE 19880-0402
    Am J Hypertens 5:209S-220S. 1992
    ..biphenyl-4-yl)methyl]imidazole, potassium salt), a highly potent angiotensin type 1 (AT1) selective receptor antagonist with a long duration of action...
  64. ncbi Production of angiotensin II receptors type one (AT1) and type two (AT2) during the differentiation of 3T3-L1 preadipocytes
    H Mallow
    , Genetik und Mikrobiologie, , Germany
    Horm Metab Res 32:500-3. 2000
    ..In this study, we directly monitored the production of angiotensin II type one receptor (AT1) and angiotensin II type two receptor (AT2) proteins during the adipose conversion of murine 3T3-L1 preadipocytes ..
  65. ncbi Molecular cloning of AT1 angiotensin receptors
    T J Murphy
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322
    Am J Hypertens 5:236S-242S. 1992
    ..isolated rat cDNA's and genes encoding two distinct but highly similar isoforms of AT1 receptors, termed AT1a and AT1b receptors...
  66. ncbi [Gene expression of the renin-angiotensin system in compensatory renal hypertrophy secondary to contralateral nephrectomy]
    J P Valentin
    Division of Nephrology, San Francisco General Hospital, University of California, USA
    Arch Mal Coeur Vaiss 87:1115-7. 1994
    ..of the remnant kidney to unilateral nephrectomy (UNX), we measured renin, angiotensinogen, and angiotensin II type 1 receptor (AT1) mRNA levels as well as angiotensin II receptor density in 2 groups of 7 Sprague-Dawley rats 7 ..
  67. ncbi [Are the antagonists of angiotensin II AT1 receptors protectors of the kidney?]
    G Deray
    , , Paris
    Arch Mal Coeur Vaiss 92:903-7. 1999
    ..In this review, the authors report the data concerning the protective effects of antagonists of angiotensin II AT1 receptors (AT1ra)...
  68. ncbi Angiotensin II receptors and functional correlates
    P B Timmermans
    Du Pont Merck Pharmaceutical Company, Wilmington, DE 19880-0400
    Am J Hypertens 5:221S-235S. 1992
    ..Rat AT1-receptor subtypes have been cloned and sequenced (AT1A and AT1B). Human ANG II receptors have also been cloned and shown to have high affinity for losartan...
  69. ncbi Angiotensin II receptor subtypes
    P B Timmermans
    Du Pont Merck Pharmaceutical Company, Wilmington, DE 19880-0400
    Am J Hypertens 5:406-10. 1992
    ..The sites having high affinity for DuP 753 are designated as site 1 (AT1 receptors) and those having a high affinity for PD 123177 as site 2 (AT2 receptors)...
  70. ncbi Heart failure: future treatment approaches
    J N Cohn
    University of Minnesota Medical School, Minneapolis 55455, USA
    Am J Hypertens 13:74S-78S. 2000
    ..Angiotensin II receptor blockers (ARB) inhibit the AT1 angiotensin receptor, which mediates the deleterious effects of the renin-angiotensin system, and may provide ..
  71. ncbi Comparison of the effects of AT1 receptor blockade and angiotensin converting enzyme inhibition on atherosclerosis
    S Hope
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts 02118, USA
    Am J Hypertens 12:28-34. 1999
    ..provides similar effects as those observed with ACE inhibition, we examined the influence of irbesartan, an AT1 receptor antagonist, on aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits using the identical ..
  72. ncbi Angiotensin II receptor blockade and end-organ protection
    O Chung
    Institute of Pharmacology, Christian-Albrechts-University Kiel, Germany
    Am J Hypertens 12:150S-156S. 1999
    ..At least two subtypes of angiotensin II receptors have been identified: AT1 and AT2. The AT1 mediates all of the known actions of Ang II on blood pressure control...
  73. ncbi Update on the clinical pharmacology of candesartan cilexetil
    H Gavras
    Hypertension and Atherosclerosis Section, Boston University Medical Center, Massachusetts 02118-2526, USA
    Am J Hypertens 13:25S-30S. 2000
    ..of angiotensin converting enzyme inhibitors, and more recently with nonpeptidic ARB that selectively antagonize the AT1-angiotensin receptor subtype...
  74. ncbi Effect of acute and chronic losartan therapy on active and inactive renin and active renin glycoforms
    J A Opsahl
    School of Medicine, University of Minnesota, Minneapolis, USA
    Am J Hypertens 8:1090-8. 1995
    ..We studied the effect of acute and chronic (42 days) stimulation of the renin angiotensin system with the AT1 selective angiotensin II receptor antagonist losartan on plasma active renin, active renin glycoforms separated by ..
  75. ncbi [Interaction between SR 47436, a new angiotensin II antagonist and sympathetic nervous system in pithed SHR rats]
    N Moreau
    ,
    Arch Mal Coeur Vaiss 86:1269-74. 1993
    ..the present study was to examine the influence of selective inhibition of endogenous AII by SR 47436, a non peptide AT1-receptor antagonist, on the sympathetic nervous system...
  76. ncbi Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension
    S Takami
    Department of Geriatric Medicine, Osaka University Medical School, Suita City, Japan
    Am J Hypertens 11:316-21. 1998
    ..To examine the genetic contribution of angiotensin II type 1 receptor (AT1) and type 2 receptor (AT2) genes in human essential hypertension, a case-control study was ..
  77. ncbi Renoprotection and renin-angiotensin system blockade in diabetes mellitus
    L M Ruilope
    Universidad Complutense, Chief Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain
    Am J Hypertens 10:325S-331S. 1997
    ..The ability of RAS blockade using irbesartan, an AT1 angiotensin II receptor antagonist, to slow the progression in renal failure has been compared with that of the ..
  78. ncbi The renin-angiotensin system and compensatory renal hypertrophy in the rat
    J P Valentin
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, 94110, USA
    Am J Hypertens 10:397-402. 1997
    ..renal growth following unilateral nephrectomy (UNX), we measured renin, angiotensinogen, and Ang II type 1 (AT1) receptor mRNA levels, as well as Ang II receptor density, in two groups of Sprague-Dawley rats 7 days after either ..
  79. ncbi Effects of ANG II and III and angiotensin receptor blockers on nasal salt gland secretion and arterial blood pressure in conscious Pekin ducks (Anas platyrhynchos)
    D G Butler
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol B 168:213-24. 1998
    ..The AT1 receptor antagonist, losartan (DuP 753) and the AT2 receptor antagonist, PD 123319 both failed to block the ..
  80. ncbi Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs
    V Richard
    , , , France
    Br J Pharmacol 110:969-74. 1993
    ..e., an angiotensin II (AT1) antagonist, EXP3174, and an angiotensin I-converting enzyme inhibitor (ACEI), enalaprilat in a canine model of ..
  81. ncbi Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study
    S Takami
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Am J Hypertens 13:121-7. 2000
    ..angiotensin converting enzyme (ACE)/Insertion(I)-Deletion(D), angiotensinogen (AGT)/M235T, angiotensin II type 1 receptor (AT1)/ A1166C, type 2 receptor (AT2)/C3123A, to examine the association between polymorphisms and the ..
  82. ncbi Interrupting the renin-angiotensin system: the role of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of hypertension
    M A Weber
    Department of Medicine, The Brookdale University Hospital and Medical Center, Brooklyn, New York 11212, USA
    Am J Hypertens 12:189S-194S. 1999
    ..Angiotensin II receptor blockers (ARB) selectively block the angiotensin II type 1 (AT1) receptor that not only mediates the known effects of angiotensin II but, according to recent reports, might be ..
  83. ncbi Comparison of the transplacental transfer of enalapril, captopril and losartan in sheep
    K M Stevenson
    School of Physiology and Pharmacology, University of New South Wales, Syndey, Australia
    Br J Pharmacol 114:1495-501. 1995
    ..Thus, the transplacental transfer of these drugs does not parallel their lipid solubilities. Furthermore the results show that AT1 receptors are important in mediating the vasoconstrictor effects of AII in the foetus.
  84. ncbi [Activation of the renin-angiotensin system and blood pressure variability in rats]
    J Blanc
    Laboratoire de Pharmacologie, CNRS UMR 8604, , Paris
    Arch Mal Coeur Vaiss 93:1019-22. 2000
    ..A second group (n = 8) received a bolus of the angiotensin II (AII) AT1 receptor-antagonist valsartan (2 mg/kg/mL, i.a.) prior to isoprenaline infusions...
  85. ncbi Lack of involvement of bradykinin in the vascular sympathoinhibitory effects of angiotensin converting enzyme inhibitors in spontaneously hypertensive rats
    B Chauvin
    , , , France
    Br J Pharmacol 116:2229-36. 1995
    ..2. Adult SHRs were treated daily for 8 days with either perindopril (3 mg kg-1), or a selective angiotensin II AT1 receptor antagonist, losartan (10 mg kg-1) both given orally--these two doses being equipotent in inhibiting ..
  86. ncbi A pharmacodynamic study of SR 47436, a selective AT1 receptor antagonist, on blood pressure in conscious cynomolgus monkeys
    A Roccon
    Cardiovascular Department, Sanofi Recherche, Montpellier, France
    Br J Pharmacol 111:145-50. 1994
    ..plasma AII, and hypotensive effect obtained after a single oral dose of SR 47436, a potent and specific nonpeptide AT1 receptor antagonist...
  87. ncbi Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals
    A Tanabe
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College, Japan
    Horm Metab Res 30:490-5. 1998
    ..of angiotensin II, the gene expression and biological significance of the angiotensin II receptor subtypes, AT1 and AT2, in the human adrenal have not been characterized...
  88. ncbi Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibition
    R Dechend
    , , Humboldt University of Berlin, Germany
    Am J Hypertens 14:55S-61S. 2001
    Angiotensin (Ang) II is capable of producing inflammatory changes by signals through its AT1 receptor. Reactive oxygen species production, adhesion molecule expression, chemokines, and other mediators are involved...
  89. ncbi Effects of chronic treatment with losartan and enalaprilat on [3H]-norepinephrine release from isolated atria of Wistar-Kyoto and spontaneously hypertensive rats
    S Foucart
    , , , Canada
    Am J Hypertens 9:61-9. 1996
    The present study was designed to evaluate the effect of chronic treatment with losartan, an AT1 angiotensin II receptor antagonist, and enalaprilat, an angiotensin converting enzyme inhibitor, on the presynaptic modulation of [3H]-..
  90. ncbi In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996
    S D Kivlighn
    Department of Cardiovascular Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Am J Hypertens 8:58-66. 1995
    ..Therefore, MK-996 is a potent, orally active, nonpeptide AII receptor antagonist with a long duration of action, little species variability, and anti-hypertensive activity...
  91. ncbi Reduction of development of left ventricular hypertrophy in salt-loaded Dahl salt-sensitive rats by angiotensin II receptor inhibition
    G De Simone
    Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021, USA
    Am J Hypertens 9:216-22. 1996
    To determine the effect of the angiotensin II AT1 receptor antagonist losartan (DuP753) on echocardiographic left ventricular (LV) anatomy in Dahl rats on high sodium diet, 27 Dahl salt-sensitive (Dahl-S, 13 on drug and 14 receiving tap ..
  92. ncbi Newly emerging pharmacologic differences in angiotensin II receptor blockers
    S Oparil
    University of Alabama at Birmingham, USA
    Am J Hypertens 13:18S-24S. 2000
    ..These drugs share a common mechanism of action-antagonism of angiotensin II AT1 receptors; however, their receptor binding kinetics differ...
  93. ncbi BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174
    K E Dickinson
    Department of Cardiovascular Biochemistry, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543 4000
    Br J Pharmacol 113:179-89. 1994
    ..125I]-Sar1Ile8AII ([125I]SI-AII) binding to rat aortic smooth muscle (RASM) cell and rat adrenal cortical AT1 receptors (Ki = 7.6 +/- 1.2 and 18.4 +/- 3.9 nM respectively) compared to adrenal cortical AT2 receptors (Ki = 37...
  94. ncbi Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor
    D E Dostal
    Weis Center for Research, Geisinger Clinic, Danville, PA 17822
    Am J Hypertens 5:276-80. 1992
    ..These in vivo studies indicate that AII-induced cardiac hypertrophy is mediated through AT1 angiotensin receptors.
  95. ncbi Acute myocardial and vascular responses to specific angiotensin II antagonism in the spontaneously hypertensive rat
    R J Cody
    Department of Medicine, Ohio State University Medical Center, Columbus 43210, USA
    Am J Hypertens 8:500-8. 1995
    As the AT1 receptor is the primary angiotensin II receptor in the myocardium and vasculature, we assessed the acute myocardial and vascular response to the AT1 angiotensin II antagonist losartan in the spontaneously hypertensive rat (SHR)..
  96. ncbi Comparative efficacy of two angiotensin II receptor antagonists, irbesartan and losartan in mild-to-moderate hypertension. Irbesartan/Losartan Study Investigators
    K Kassler-Taub
    Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA
    Am J Hypertens 11:445-53. 1998
    ..were to compare the antihypertensive efficacy and tolerability of irbesartan and losartan, two angiotensin II (AT1 subtype) receptor antagonists with different pharmacokinetic profiles in patients with mild-to-moderate ..
  97. ncbi Clinical overview of irbesartan: a new angiotensin II receptor antagonist
    H G Pouleur
    Department of Cardiovascular Clinical Research, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA
    Am J Hypertens 10:318S-324S. 1997
    Irbesartan is an angiotensin II receptor (AT1 subtype) antagonist that has been extensively studied in the Bristol-Myers Squibb/Sanofi clinical development program...
  98. ncbi Angiotensinogen dependency of blood pressure in two high-renin hypertensive rat models
    F Gahnem
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    Am J Hypertens 7:899-904. 1994
    ..The Aogn relationship to BP was most likely dependent on the vasoconstrictor effect of AngII since it was lost during AngII AT1 receptor antagonism.
  99. ncbi AT1 receptors: coronary flow and flow reserve
    E D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 13:39S-44S. 2000
    ..This finding suggests a possible advantage of combination angiotensin converting enzyme inhibitors and angiotensin II receptor blocker therapy in patients with hypertension and hypertensive heart disease...
  100. ncbi Regional haemodynamic responses to pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide in conscious rats
    S M Gardiner
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 111:589-97. 1994
    ..5 nmol kg-1 h-1), and also abolished the renal vasoconstrictor effects of VIP. 6. The AT1-receptor antagonist, losartan potassium (20 mumol kg-1), had no significant effect on the haemodynamic response to ..

Research Grants82

  1. MOLECULAR BASIS FOR ANGIOTENSIN II RECEPTOR FUNCTION(S)
    Sadashiva Karnik; Fiscal Year: 2005
    ..The type 1 (AT1) receptor mediates diverse intracellular responses to Ang II in the regulation of blood pressure, hydromineral ..
  2. Renal Angiotensin II Receptor Function in Obesity
    Tahir Hussain; Fiscal Year: 2009
    ..Of the two Ang II receptors, AT1 is known to mediate most of the Ang II actions such as antinatriuresis and increased blood pressure (BP)...
  3. Renal Angiotensin II Receptor Function in Obesity
    Tahir Hussain; Fiscal Year: 2010
    ..Of the two Ang II receptors, AT1 is known to mediate most of the Ang II actions such as antinatriuresis and increased blood pressure (BP)...
  4. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    Robert Wayne Alexander; Fiscal Year: 2010
    ..II (AngII) is a potent stimulator of vascular hypertrophy which is mediated through the Ang II typel receptor (AT1R) in vascular smooth muscle cells (VSMCs)...
  5. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    R Alexander; Fiscal Year: 2007
    ..II (Ang II) is a potent stimulator of vascular hypertrophy which is mediated through the Ang II type l receptor (AT1R) in vascular smooth muscle cells (VSMCs)...
  6. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    R Alexander; Fiscal Year: 2009
    ..II (AngII) is a potent stimulator of vascular hypertrophy which is mediated through the Ang II typel receptor (AT1R) in vascular smooth muscle cells (VSMCs)...
  7. Central actions of angiotensin II in the control of fluid balance
    LORI MARIE FLANAGAN CATO; Fiscal Year: 2011
    ..The Type 1 (AT1) AngII receptor subtype is primarily responsible for the physiological and behavioral responses to this peptide...
  8. Central actions of angiotensin II in the control of fluid balance
    DANIEL K contact YEE; Fiscal Year: 2010
    ..The Type 1 (AT1) AngII receptor subtype is primarily responsible for the physiological and behavioral responses to this peptide...
  9. Central actions of angiotensin II in the control of fluid balance
    Daniel Yee; Fiscal Year: 2009
    ..The Type 1 (AT1) AngII receptor subtype is primarily responsible for the physiological and behavioral responses to this peptide...
  10. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2009
    ..Compared to rat in which two genes (AT1A, AT1B) code for AT1 receptor, in humans, a single gene code for angiotensin type 1 (hAT1), suggesting species specific ..
  11. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2007
    ..Compared to rat in which two genes (AT1A, AT1B) code for AT1 receptor, in humans, a single gene code for angiotensin type 1 (hAT1), suggesting species specific ..
  12. Angiotensin II Receptor Blockade and Chronic Rejection
    Bryan Becker; Fiscal Year: 2003
    ..We have available therapies to alter this axis by pharmacological blockade of the predominant Ang II receptor, AT1R, and this treatment reduces TGF-beta levels in experimental studies...
  13. MOLECULAR BASIS FOR ANGIOTENSIN II RECEPTOR FUNCTION(S)
    Sadashiva Karnik; Fiscal Year: 2000
    ..Two isoforms of Ang II receptors, AT1 and AT2 that belong to the superfamily of G protein coupled receptors (GPCR) mediate these responses...
  14. Molecular Basis of Ang II Receptor Functions
    Sadashiva S Karnik; Fiscal Year: 2010
    The long-term goal of our research program is to elucidate the structure-function basis of angiotensin II type 1 receptor (AT1R)...
  15. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2010
    ..The angiotensin (Ang) converting enzyme (ACE), Ang II and Ang AT1 receptor of the renin-angiotensin system (RAS) participate in the pathophysiology of various cardiovascular ..
  16. POSTTRANSCRIPTIONAL REGULATION OF ANGIOTENSIN RECEPTORS
    KATHRYN L SANDBERG; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): In the rat, two distinct angiotensin type 1a receptor (AT1aR) mRNAs are synthesized from a single AT1aR gene. These transcripts are comprised of exons 1 and 3 (E1,3) and exons 1, 2 and 3 (E1,2,3)...
  17. POSTTRANSCRIPTIONAL REGULATION OF ANGIOTENSIN RECEPTORS
    Kathryn Sandberg; Fiscal Year: 2009
    In the rat, two distinct angiotensin type 1a receptor (AT1aR) mRNAs are synthesized from a single AT1aR gene. These transcripts are comprised of exons 1 and 3 (E1,3) and exons 1, 2 and 3 (E1,2,3)...
  18. POSTTRANSCRIPTIONAL REGULATION OF ANGIOTENSIN RECEPTORS
    KATHRYN L SANDBERG; Fiscal Year: 2010
    In the rat, two distinct angiotensin type 1a receptor (AT1aR) mRNAs are synthesized from a single AT1aR gene. These transcripts are comprised of exons 1 and 3 (E1,3) and exons 1, 2 and 3 (E1,2,3)...
  19. RENAL ANGIOTENSIN II RECEPTOR AND SODIUM INTAKE
    Donna Wang; Fiscal Year: 2000
    ..is to understand the molecular mechanisms that govern differential regulation of the type-1 angiotensin II (AT1) receptor expression in specific segments of the nephron in response to altered sodium intake...
  20. HORMONAL REGULATION OF ANGIOTENSIN RECEPTORS
    Kathryn Sandberg; Fiscal Year: 2007
    ..the state of menopause by ovariectomy in several species, increased the density of angiotensin type 1 receptors (AT1R) in the adrenal and kidney, which are two key target tissues of the renin angiotensin system (RAS) that are ..
  21. HORMONAL REGULATION OF ANGIOTENSIN RECEPTORS
    Kathryn Sandberg; Fiscal Year: 2009
    ..the state of menopause by ovariectomy in several species, increased the density of angiotensin type 1 receptors (AT1R) in the adrenal and kidney, which are two key target tissues of the renin angiotensin system (RAS) that are ..
  22. HORMONAL REGULATION OF ANGIOTENSIN RECEPTORS
    KATHRYN L SANDBERG; Fiscal Year: 2010
    ..the state of menopause by ovariectomy in several species, increased the density of angiotensin type 1 receptors (AT1R) in the adrenal and kidney, which are two key target tissues of the renin angiotensin system (RAS) that are ..
  23. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    Shannon Glaser; Fiscal Year: 2009
    ..disorders, induces cholangiocyte proliferation via mechanical activation of the angiotensin type 1 receptor (AT1)...
  24. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ..disorders, induces cholangiocyte proliferation via mechanical activation of the angiotensin type 1 receptor (AT1)...
  25. CONTROL OF ANGIOTENSIN II RECEPTOR GENE EXPRESSION
    Kathryn Sandberg; Fiscal Year: 2007
    In the rat, two distinct angiotensin type la receptor (AT1aR) mRNAs are synthesized from a single ATtaR Lene by alternative splicing. These transcripts are encoded by exons 1 and 3 (E1,3) and exons 1, 2, and 3 (E1,2,3)...
  26. HUMAN ANGIOTENSIN II RECEPTOR GENE REGULATION
    Terry Elton; Fiscal Year: 2005
    ..While characterizing the human AT1R (hAT1R) gene, it was demonstrated that human tissues can express at least eight alternatively spliced hAT1R mRNA ..
  27. HORMONAL REGULATION OF ANGIOTENSIN RECEPTORS
    Kathryn Sandberg; Fiscal Year: 2005
    ..in the proposed studies are: 1) estrogen down- regulates the density of the type 1 angiotensin receptor subtype (AT1) expressed in adrenal and kidney tissues and thereby attenuates tissue responsiveness to the hormone, angiotensin ..
  28. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas Coffman; Fiscal Year: 2007
    The actions of the renin-angiotensin system (RAS) to control blood pressure are primarily mediated by type 1 (AT1) angiotensin receptors...
  29. Angiotensin Receptors in Central Osmonsensitivity
    Mariana Morris; Fiscal Year: 2005
    ..AT1 receptors exist in two forms, AT1a and AT1b, which are homologous in gene and protein structure, making it impossible to distinguish pharmacologically...
  30. Salt appetite & vascular remodeling in fetal origin
    Zhice Xu; Fiscal Year: 2010
    ..the effects of maternal high salt ingestion on the development of fetal swallowing behavior, ANG receptor subtypes-AT1?R and AT2-R, and vascular homeostasis, as well as long-term programming influence on cardiovascular regulation in ..
  31. Salt appetite & vascular remodeling in fetal origin
    Zhice Xu; Fiscal Year: 2009
    ..the effects of maternal high salt ingestion on the development of fetal swallowing behavior, ANG receptor subtypes-AT1?R and AT2-R, and vascular homeostasis, as well as long-term programming influence on cardiovascular regulation in ..
  32. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2006
    ..Compared to rat in which two genes (AT1A, AT1B) code for AT1 receptor, in humans, a single gene codes for angiotensin type 1 (hAT1), suggesting species-specific ..
  33. Novel Aspects of the Cardiac Renin-Angiotensin System
    KENNETH MELVIN BAKER; Fiscal Year: 2010
    ..The effects of angiotensin II (Ang II) are primarily mediated by binding to AT1 receptor in an endocrine and/or autocrine/paracrine manner...
  34. Novel Aspects of the Cardiac Renin-Angiotensin System
    Kenneth Baker; Fiscal Year: 2009
    ..The effects of angiotensin II (Ang II) are primarily mediated by binding to AT1 receptor in an endocrine and/or autocrine/paracrine manner...
  35. ANG II/AT1 RECEPTORS WITH PET
    Zsolt Szabo; Fiscal Year: 1999
    ..PET studies will employ a novel radioligand, [C-11]L-159,884, which is an AT1 specific receptor antagonist...
  36. OXIDATIVE STRESS AND DIABETIC CARDIOMYOPATHY
    Piero Anversa; Fiscal Year: 2003
    ..II Hyperglycemia-mediated enzymatic glycosylation of p53 may enhance transcription of angiotensinogen (Aogen) and AT1 receptor; Aogen is the limiting factor in the generation of Ang II and the AT1 effector pathway conditions cardiac ..
  37. Fetal origins of adult hypertension in microswine
    Susan Bagby; Fiscal Year: 2007
    ..generation; and 2) increased renal microvascular contractile reactivity to AnglI despite reduced AT1 receptor (AT1R) density, suggesting post-receptor enhancement of AT1R contractile signaling efficiency...