AGR2

Summary

Gene Symbol: AGR2
Description: anterior gradient 2, protein disulphide isomerase family member
Alias: AG-2, AG2, GOB-4, HAG-2, HEL-S-116, HPC8, PDIA17, XAG-2, anterior gradient protein 2 homolog, anterior gradient homolog 2, epididymis secretory protein Li 116, protein disulfide isomerase family A, member 17, secreted cement gland homolog, secreted cement gland protein XAG-2 homolog
Species: human
Products:     AGR2

Top Publications

  1. Thompson D, Weigel R. hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. Biochem Biophys Res Commun. 1998;251:111-6 pubmed
    ..Coexpression of hAG-2 with ER suggests that hAG-2 may be involved in the tumor biology specific to the well-differentiated phenotype of hormonally-responsive breast cancers. ..
  2. Petek E, Windpassinger C, Egger H, Kroisel P, Wagner K. Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation. Cytogenet Cell Genet. 2000;89:141-2 pubmed
  3. Gupta A, Dong A, Lowe A. AGR2 gene function requires a unique endoplasmic reticulum localization motif. J Biol Chem. 2012;287:4773-82 pubmed publisher
    ..The present study determines whether AGR2 requires a specific ER localization signal to be functionally active...
  4. Brychtova V, Hermanova M, Karasek P, Lenz J, Selingerova I, Vojtesek B, et al. Anterior gradient 2 and mucin 4 expression mirrors tumor cell differentiation in pancreatic adenocarcinomas, but aberrant anterior gradient 2 expression predicts worse patient outcome in poorly differentiated tumors. Pancreas. 2014;43:75-81 pubmed publisher
    This study aimed to determine anterior gradient 2 (AGR2) expression in biopsies from pancreatic ductal adenocarcinomas (PDACs) and to evaluate AGR2 as a potential independent prognostic factor...
  5. Higa A, Mulot A, Delom F, Bouchecareilh M, Nguy n D, Boismenu D, et al. Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis. J Biol Chem. 2011;286:44855-68 pubmed publisher
    The protein-disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) is reportedly overexpressed in numerous cancers and plays a role in cancer development...
  6. Zhang Y, Forootan S, Liu D, Barraclough R, Foster C, Rudland P, et al. Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients. Prostate Cancer Prostatic Dis. 2007;10:293-300 pubmed
    Anterior gradient-2 (AGR2) expression was examined in a series of prostate cell lines and in an archival set of prostate tissues. The relative levels of AGR2 expression in the malignant cell lines PC-3 and PC-3M were, respectively, 5...
  7. Zweitzig D, Smirnov D, Connelly M, Terstappen L, O Hara S, Moran E. Physiological stress induces the metastasis marker AGR2 in breast cancer cells. Mol Cell Biochem. 2007;306:255-60 pubmed
    ..These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen...
  8. Park K, Chung Y, So H, Kim K, Park J, Oh M, et al. AGR2, a mucinous ovarian cancer marker, promotes cell proliferation and migration. Exp Mol Med. 2011;43:91-100 pubmed
    ..To search for a biomarker for the early detection of ovarian cancer, we identified human anterior gradient 2 (AGR2) from our systematic analysis of paired normal and ovarian tumor tissue cDNA microarray...
  9. Vivekanandan P, Micchelli S, Torbenson M. Anterior gradient-2 is overexpressed by fibrolamellar carcinomas. Hum Pathol. 2009;40:293-9 pubmed publisher
    ..In conclusion, anterior gradient-2 is overexpressed in the majority of fibrolamellar carcinomas but is only rarely overexpressed in hepatocellular carcinomas. ..

More Information

Publications81

  1. Chen R, Pan S, Duan X, Nelson B, Sahota R, de Rham S, et al. Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia. Mol Cancer. 2010;9:149 pubmed publisher
    ..We applied quantitative proteomics to identify aberrantly elevated proteins in pancreatic juice samples derived from patients with PanIN3...
  2. Sweeny L, Liu Z, Bush B, Hartman Y, Zhou T, Rosenthal E. CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma. Exp Cell Res. 2012;318:1788-98 pubmed publisher
    ..CD147 is a transmembrane glycoprotein known to induce cell migration and invasion. AGR2 is a secreted peptide also known to promote cell metastasis...
  3. Maresh E, Mah V, Alavi M, Horvath S, Bagryanova L, Liebeskind E, et al. Differential expression of anterior gradient gene AGR2 in prostate cancer. BMC Cancer. 2010;10:680 pubmed publisher
    The protein AGR2 is a putative member of the protein disulfide isomerase family and was first identified as a homolog of the Xenopus laevis gene XAG-2. AGR2 has been implicated in a number of human cancers...
  4. Vanderlaag K, Hudak S, Bald L, Fayadat Dilman L, Sathe M, Grein J, et al. Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin. Breast Cancer Res. 2010;12:R32 pubmed publisher
    Anterior-gradient 2 (AGR2) is an estrogen-responsive secreted protein...
  5. Zhang Y, Ali T, Zhou H, D Souza D, Lu Y, Jaffe J, et al. ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer. Cancer Res. 2010;70:240-8 pubmed publisher
    Dysregulation of the developmental gene anterior gradient protein 2 (AGR2) has been associated with a metastatic phenotype, but its mechanism of action and control in prostate cancers is unknown...
  6. Park S, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu L, Barczak A, et al. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009;106:6950-5 pubmed publisher
    ..A recent homology-based search for additional PDI family members identified anterior gradient homolog 2 (AGR2), a protein originally presumed to be secreted by intestinal epithelial cells...
  7. Riener M, Pilarsky C, Gerhardt J, Grutzmann R, Fritzsche F, Bahra M, et al. Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma. Histol Histopathol. 2009;24:1121-8 pubmed publisher
    The human Anterior Gradient-2 (AGR2) is strongly upregulated in various human cancers, including pancreatic ductal adenocarcinomas (PDAC), but its prognostic value in PDAC has not yet been studied...
  8. Yu H, Zhao J, Lin L, Zhang Y, Zhong F, Liu Y, et al. Proteomic study explores AGR2 as pro-metastatic protein in HCC. Mol Biosyst. 2012;8:2710-8 pubmed publisher
    ..We found that high-expression levels of AGR2 existed in metastatic HCC cell lines and patient samples...
  9. Bu H, Bormann S, Schafer G, Horninger W, Massoner P, Neeb A, et al. The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection. Prostate. 2011;71:575-87 pubmed publisher
    b>AGR2 is a member of the endoplasmatic reticulum protein disulphide isomerase gene family implicated in tumor metastasis. Its expression pattern, function, and utility as a marker remains to be further investigated...
  10. Valladares Ayerbes M, Díaz Prado S, Reboredo M, Medina V, Iglesias Díaz P, Lorenzo Patiño M, et al. Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer. Cancer Detect Prev. 2008;32:236-50 pubmed publisher
    ..Among all the genes assessed, PKP3, AGR2, S100A16, S100A6, LGALS4, and CLDN3 were selected and assays based on blood qRT-PCR were developed...
  11. Fletcher G, Patel S, Tyson K, Adam P, Schenker M, Loader J, et al. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br J Cancer. 2003;88:579-85 pubmed
    ..hAG-2 and hAG-3 may therefore serve as useful molecular markers and/or potential therapeutic targets for hormone-responsive breast tumours. ..
  12. Zhang J, Gong A, Cheville J, Smith D, Young C. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer. 2005;43:249-59 pubmed
    b>AGR2, the human homologue of Xenopus anterior gradient 2 (XAG2), was identified by a suppression subtractive hybridization-based technique as an androgen-inducible gene...
  13. Patel P, Clarke C, Barraclough D, Jowitt T, Rudland P, Barraclough R, et al. Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion. J Mol Biol. 2013;425:929-43 pubmed publisher
    Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion...
  14. Chung K, Nishiyama N, Yamano S, Komatsu H, Hanada S, Wei M, et al. Serum AGR2 as an early diagnostic and postoperative prognostic biomarker of human lung adenocarcinoma. Cancer Biomark. 2011;10:101-7 pubmed publisher
    In the present study, the human orthologue of the secreted Xenopus laevis anterior gradient 2 (AGR2) protein was evaluated as a potential serum biomarker of lung adenocarcinoma...
  15. Persson S, Rosenquist M, Knoblach B, Khosravi Far R, Sommarin M, Michalak M. Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family. Mol Phylogenet Evol. 2005;36:734-40 pubmed
  16. Zheng W, Rosenstiel P, Huse K, Sina C, Valentonyte R, Mah N, et al. Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease. Genes Immun. 2006;7:11-8 pubmed
    ..The genes encoding for the human homologues AGR2 and AGR3 are localized on chromosome 7p21.3...
  17. Barraclough D, Platt Higgins A, De Silva Rudland S, Barraclough R, Winstanley J, West C, et al. The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients. Am J Pathol. 2009;175:1848-57 pubmed publisher
    The secreted metastasis-inducing protein, human anterior gradient 2 (AGR2), has been independently reported to be associated with either a reduced or an increased survival of different groups of patients with breast cancer...
  18. Pizzi M, Fassan M, Balistreri M, Galligioni A, Rea F, Rugge M. Anterior gradient 2 overexpression in lung adenocarcinoma. Appl Immunohistochem Mol Morphol. 2012;20:31-6 pubmed publisher
    ..Querying the Oncomine database pinpointed anterior gradient 2 (AGR2) as being upregulated in lung AdC...
  19. Wayner E, Quek S, Ahmad R, Ho M, Loprieno M, Zhou Y, et al. Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine. Prostate. 2012;72:1023-34 pubmed publisher
    Comparative transcriptomics between sorted cells identified AGR2 as one of the highest up-regulated genes in cancer. Overexpression in primary tumors was verified by tissue microarray analysis...
  20. Dong A, Gupta A, Pai R, Tun M, Lowe A. The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation. J Biol Chem. 2011;286:18301-10 pubmed publisher
    b>Anterior Gradient Homolog 2 (AGR2) is expressed by the normal intestine and by most human adenocarcinomas, including those derived from the esophagus, pancreas, lung, breast, ovary, and prostate...
  21. Ramachandran V, Arumugam T, Wang H, Logsdon C. Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival. Cancer Res. 2008;68:7811-8 pubmed publisher
    ..In the current study, we investigated the role of anterior gradient 2 (AGR2) in these processes...
  22. Maslon M, Hrstka R, Vojtesek B, Hupp T. A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin. J Mol Biol. 2010;404:418-38 pubmed publisher
    Anterior gradient-2 (AGR2) functions in a range of biological systems, including goblet cell formation, limb regeneration, inhibition of p53, and metastasis...
  23. Fritzsche F, Dahl E, Pahl S, Burkhardt M, Luo J, Mayordomo E, et al. Prognostic relevance of AGR2 expression in breast cancer. Clin Cancer Res. 2006;12:1728-34 pubmed
    We aimed to evaluate the expression of the human anterior gradient-2 (AGR2) in breast cancer on RNA and protein level and to correlate it with clinicopathologic data, including patient survival...
  24. Dumartin L, Whiteman H, Weeks M, Hariharan D, Dmitrovic B, Iacobuzio Donahue C, et al. AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D. Cancer Res. 2011;71:7091-102 pubmed publisher
    ..Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic cancer...
  25. Gray T, Alsamman K, Murray E, Sims A, Hupp T. Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2. Mol Biosyst. 2014;10:1409-25 pubmed publisher
    b>AGR2 forms an ER-resident signalling axis in cell development, limb regeneration, and in human diseases like asthma and cancer, yet molecular mechanisms underlying its effects remain largely undefined...
  26. Ho M, Quek S, True L, Morrissey C, Corey E, Vessella R, et al. Prostate cancer cell phenotypes based on AGR2 and CD10 expression. Mod Pathol. 2013;26:849-59 pubmed publisher
    The combination of expression patterns of AGR2 (anterior gradient 2) and CD10 by prostate cancer provided four phenotypes that correlated with clinical outcome...
  27. Ambolet Camoit A, Bui L, Pierre S, Chevallier A, Marchand A, Coumoul X, et al. 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2. Toxicol Sci. 2010;115:501-12 pubmed publisher
    ..interfering RNA knockdown experiments, we found that the newly described metastasis marker, anterior gradient-2 (AGR2), is involved in this effect...
  28. Chevet E, Fessart D, Delom F, Mulot A, Vojtesek B, Hrstka R, et al. Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development. Oncogene. 2013;32:2499-509 pubmed publisher
    ..The pro-oncogenic protein anterior gradient 2 (AGR2) is a case in point; AGR2 has been shown using a range of expression platforms to be involved in asthma, ..
  29. Ryu J, Park S, Lee P, Cho S, Lee D, Kim G, et al. Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78. Biochem Biophys Res Commun. 2013;430:610-5 pubmed publisher
    Anterior Gradient 2 (AGR2), an ER stress-inducible protein, has been reported to be localized in endoplasmic reticulum (ER) and its level is elevated in numerous metastatic cancers...
  30. Kim S, Kim D, Kang D, Kim J. Expression of anterior gradient 2 is decreased with the progression of human biliary tract cancer. Tohoku J Exp Med. 2014;234:83-8 pubmed
    ..The anterior gradient 2 (AGR2) is a protein disulfide isomerase and is highly expressed in various human cancers, such as breast, prostate and ..
  31. Norris A, Gore A, Balboni A, Young A, Longnecker D, Korc M. AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia. Oncogene. 2013;32:3867-76 pubmed publisher
    The mechanisms controlling expression of the putative oncogene Anterior gradient 2 (AGR2) in pancreatic ductal adenocarcinoma (PDAC) are not well understood...
  32. Lepreux S, Bioulac Sage P, Chevet E. Differential expression of the anterior gradient protein-2 is a conserved feature during morphogenesis and carcinogenesis of the biliary tree. Liver Int. 2011;31:322-8 pubmed publisher
    The anterior gradient protein-2 (AGR2) is overexpressed in numerous tumours such as breast, prostate or pancreas carcinomas and recently reported in fibrolamellar hepatocellular carcinoma (HCC)...
  33. Lutz C, Hasegawa T, Chikyow T. Ag2S atomic switch-based 'tug of war' for decision making. Nanoscale. 2016;8:14031-6 pubmed publisher
    ..The devices are based on the growth and shrinkage of Ag filaments in ?-Ag2+?S gap-type atomic switches. Here we present the adapted device design and the new materials...
  34. Neeb A, Hefele S, Bormann S, Parson W, Adams F, Wolf P, et al. Splice variant transcripts of the anterior gradient 2 gene as a marker of prostate cancer. Oncotarget. 2014;5:8681-9 pubmed
    Anterior gradient 2 (AGR2) is a gene predominantly expressed in mucus-secreting tissues or in endocrine cells. Its expression is drastically increased in tumors including prostate cancer...
  35. DiMaio M, Kwok S, Montgomery K, Lowe A, Pai R. Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: a combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping. Hum Pathol. 2012;43:1799-807 pubmed publisher
    ..markers (p63, cytokeratin 5/6, cytokeratin 7, CDX2, MUC2, and MUC5AC) and 2 new markers, anterior gradient homolog 2 and SOX2, in esophageal carcinomas to establish the best panel to distinguish these tumors...
  36. Capel Berdiell I, Warriner S, Halcrow M. Silver(i) complexes of bis- and tris-(pyrazolyl)azine derivatives - dimers, coordination polymers and a pentametallic assembly. Dalton Trans. 2018;47:5269-5278 pubmed publisher
    ..Dinuclear [Ag2(μ-tpp)2(MeCN)2][BF4]2·2MeCN and [Ag2(μ-tpym)2(MeCN)2][BF4]2 are formed from approximately planar [AgL(NCMe)..
  37. Özbek Ö, Görgülü E, Yıldırımlı Ş. Genetic diversity in populations of Isatis glauca Aucher ex Boiss. ssp. from Central Anatolia in Turkey, as revealed by AFLP analysis. Bot Stud. 2013;54:48 pubmed publisher
    ..The accessions formed distinctive population structures for populations AA, AB, E, K, and S. Populations AG1 and AG2 seemed to have similar genetic content, in addition, in both populations several hybrid individuals were observed...
  38. RendoÅ¡ová M, Vargová Z, Kuchár J, Sabolová D, Levoča Å, Kudláčová J, et al. New silver complexes with bioactive glycine and nicotinamide molecules - Characterization, DNA binding, antimicrobial and anticancer evaluation. J Inorg Biochem. 2017;168:1-12 pubmed publisher
    ..X-ray analysis confirmed argentophilic interactions in complex 1 with an Ag1-Ag2 distance of 2.8018(6) Ã…...
  39. Skaf M, Hany S, Aouad S, Gennequin C, Labaki M, Abi Aad E, et al. Detection of adsorbed O2- species on CeO2 solid impregnated with Ag2+ ions during its thermal treatment under a H2 atmosphere, an EPR study. Phys Chem Chem Phys. 2016;18:29381-29386 pubmed
    ..The mobility of oxygen in CeO2 and the nature of cations loaded on this support can be the origin of the adsorbed O2- species particularly when the solid is treated under H2 molecules. ..
  40. Bestgen S, Yang X, Issac I, Fuhr O, Roesky P, Fenske D. Adamantyl- and Furanyl-Protected Nanoscale Silver Sulfide Clusters. Chemistry. 2016;22:9933-7 pubmed publisher
    ..AdSH) and furan-2-ylmethanethiol (FurCH2 SH) were successfully applied as building blocks for ligand-protected Ag2 S nanoclusters...
  41. Simler T, Braunstein P, Danopoulos A. Coinage metal complexes with bridging hybrid phosphine-NHC ligands: synthesis of di- and tetra-nuclear complexes. Dalton Trans. 2016;45:5122-39 pubmed publisher
    ..Chem., Int. Ed., 2015, 54, 13691), whereas metallation of ·HBF4 (R = Ph, tBu) led to the dinuclear complexes [Ag2(L(R))2](BF4)2 which, in the solid state, feature heteroleptic Ag centres and a 'head-to-tail' (HT) arrangement of ..
  42. Xu C, Liu Y, Xiao L, Guo C, Deng S, Zheng S, et al. The involvement of anterior gradient 2 in the stromal cell-derived factor 1-induced epithelial-mesenchymal transition of glioblastoma. Tumour Biol. 2016;37:6091-7 pubmed publisher
    ..recent years, it has been widely identified that the stromal cell-derived factor 1 (SDF-1) and anterior gradient 2 (AGR2) were implicated in the development of epithelial-mesenchymal transition (EMT) in a variety of cancers...
  43. Thomas A, Janáky C, Samu G, Huda M, Sarker P, Liu J, et al. Time- and energy-efficient solution combustion synthesis of binary metal tungstate nanoparticles with enhanced photocatalytic activity. ChemSusChem. 2015;8:1652-63 pubmed publisher
    ..for stable and efficient photocatalysts beyond TiO2 , the tungsten-based oxide semiconductors silver tungstate (Ag2 WO4 ), copper tungstate (CuWO4 ), and zinc tungstate (ZnWO4 ) were prepared using solution combustion synthesis (..
  44. Pinatti I, Nogueira I, Pereira W, Pereira P, Gonçalves R, Varela J, et al. Structural and photoluminescence properties of Eu(3+) doped α-Ag2WO4 synthesized by the green coprecipitation methodology. Dalton Trans. 2015;44:17673-85 pubmed publisher
    Europium doped silver tungstates α-Ag2-3xEuxWO4 (x = 0, 0.0025, 0.005, 0.0075 and 0.01 mol) were synthesized by the coprecipitation method at 90 °C for 30 minutes...
  45. Song J, Cano Rodriquez D, Winkle M, Gjaltema R, Goubert D, Jurkowski T, et al. Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2017;312:L334-L347 pubmed publisher
    ..protein expression, which was accompanied by inhibition of downstream mucus-related genes [anterior gradient 2 (AGR2), mucin 5AC (MUC5AC)]...
  46. Pelzer S, Neumann B, Stammler H, Ignat ev N, Hoge B. Synthesis of Bis(pentafluoroethyl)germanes. Chemistry. 2016;22:4758-63 pubmed publisher
    ..The trigermoxane [(C2F5)2 GeO]3 results from the reaction of (C2F5)2 GeBr2 with Ag2 CO3. Its crystalline 1,10-phenanthroline adduct was fully characterised by X-ray diffraction...
  47. Hapangama D, Raju R, Valentijn A, Barraclough D, Hart A, Turner M, et al. Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis. Hum Reprod. 2012;27:394-407 pubmed publisher
    ..Expression of S100P, S100A4, osteopontin (OPN) or anterior gradient homologue 2 (AGR2) proteins can induce metastasis but fail to induce tumorigenesis per se...
  48. Zavras A, White J, O Hair R. An unusual co-crystal [(?2-dcpm)Ag2(?2-O2CH)(?2-NO3)]2·[(?2-dcpm)2Ag4(?2-NO3)4] and its connection to the selective decarboxylation of formic acid in the gas phase. Dalton Trans. 2016;45:19408-19415 pubmed
  49. Lai Y, Lu Y, Lien H, Huang C, Hwang S. Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos. Biochem J. 2016;473:2205-18 pubmed publisher
    Mammalian anterior gradient 2 (AGR2), an endoplasmic reticulum (ER) protein disulfide-isomerase (PDI), is involved in cancer cell growth and metastasis, asthma and inflammatory bowel disease (IBD)...
  50. Malinowski P, Himmel D, Krossing I. Coordination Chemistry of Diiodine and Implications for the Oxidation Capacity of the Synergistic Ag(+) /X2 (X=Cl, Br, I) System. Angew Chem Int Ed Engl. 2016;55:9262-6 pubmed publisher
    ..we report on an unexpectedly variable coordination chemistry of diiodine towards this direction: (A)Ag-I2 -Ag(A), [Ag2 (I2 )4 ](2+) (A(-) )2 and [Ag2 (I2 )6 ](2+) (A(-) )2 ?(I2 )x?0...
  51. Uthaisar K, Vaeteewoottacharn K, Seubwai W, Talabnin C, Sawanyawisuth K, Obchoei S, et al. Establishment and characterization of a novel human cholangiocarcinoma cell line with high metastatic activity. Oncol Rep. 2016;36:1435-46 pubmed publisher
    ..expressed genes related to progression of cancer revealed significant upregulation of anterior gradient protein-2 (AGR2) and suppression of KiSS-1 in the KKU-213L5 cells...
  52. Hu Z, Gu Y, Han B, Zhang J, Li Z, Tian K, et al. Knockdown of AGR2 induces cellular senescence in prostate cancer cells. Carcinogenesis. 2012;33:1178-86 pubmed publisher
    Anterior-gradient 2 (AGR2), overexpressed in many tumors including prostate cancer (PCa), is implicated in stimulation of cell proliferation, adhesion, anti-apoptosis and cell cycle regulation...
  53. Alavi M, Mah V, Maresh E, Bagryanova L, Horvath S, Chia D, et al. High expression of AGR2 in lung cancer is predictive of poor survival. BMC Cancer. 2015;15:655 pubmed publisher
    Anterior gradient 2 (AGR2) is a protein disulfide isomerase-like protein widely expressed in many normal tissues as well as cancers...
  54. Chanda D, Lee J, Sawant A, Hensel J, Isayeva T, Reilly S, et al. Anterior gradient protein-2 is a regulator of cellular adhesion in prostate cancer. PLoS ONE. 2014;9:e89940 pubmed publisher
    ..These data suggest that AGR-2 influence prostate cancer metastasis by regulation of cellular adhesion and apoptosis. ..
  55. Valladares Ayerbes M, Blanco Calvo M, Reboredo M, Lorenzo Patiño M, Iglesias Díaz P, Haz M, et al. Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer. Int J Mol Sci. 2012;13:4367-87 pubmed publisher
    We aim to estimate the diagnostic performances of anterior gradient homolog-2 (AGR2) and Leucine-rich repeat-containing-G-protein-coupled receptor 5 (LGR5) in peripheral blood (PB) as mRNA biomarkers in colorectal cancer (CRC) and to ..
  56. Guo H, Zhu Q, Yu X, Merugu S, Mangukiya H, Smith N, et al. Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization. Oncogene. 2017;36:5098-5109 pubmed publisher
    ..Anterior gradient-2 (AGR2) is overexpressed in diverse human adenocarcinomas and it exists in both intracellular and extracellular spaces...
  57. Hrstka R, Podhorec J, Nenutil R, Sommerova L, Obacz J, Durech M, et al. Tamoxifen-Dependent Induction of AGR2 Is Associated with Increased Aggressiveness of Endometrial Cancer Cells. Cancer Invest. 2017;35:313-324 pubmed publisher
    ..Significantly, higher AGR2 expression was found in endometrial cancers that developed in women previously treated with tamoxifen compared to ..
  58. Bednár B, Roller L, Čižmár D, Mitrová D, Zitnan D. Developmental and sex-specific differences in expression of neuropeptides derived from allatotropin gene in the silkmoth Bombyx mori. Cell Tissue Res. 2017;368:259-275 pubmed publisher
    ..region of the terminal abdominal ganglion; (3) in the female-specific medial neurons in the abdominal ganglia AG2-7...
  59. Wright T, Wardell S, Jasper J, Stice J, Safi R, Nelson E, et al. Delineation of a FOXA1/ER?/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. Mol Cancer Res. 2014;12:1829-39 pubmed publisher
    ..in this regard is the observation here and in other studies that expression of anterior gradient homology 2 (AGR2), a known proto-oncogene and disulfide isomerase, was induced by both estrogen (17?-estradiol, E2) and 4-..
  60. Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, et al. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. Lab Invest. 2015;95:193-206 pubmed publisher
    Anterior gradient 2 (AGR2), a member of the protein disulfide isomerase family, has been implicated in various cancers including pancreatic ductal adenocarcinoma (PDAC) and is known to promote cancer progression...
  61. Bergström J, Berg K, Rodríguez Piñeiro A, Stecher B, Johansson M, Hansson G. AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus. PLoS ONE. 2014;9:e104186 pubmed publisher
    ..Mice lacking the disulfide isomerase-like protein Agr2 have been shown to be more susceptible to colon inflammation...
  62. Vitello E, Quek S, Kincaid H, Fuchs T, Crichton D, Troisch P, et al. Cancer-secreted AGR2 induces programmed cell death in normal cells. Oncotarget. 2016;7:49425-49434 pubmed publisher
    Anterior Gradient 2 (AGR2) is a protein expressed in many solid tumor types including prostate, pancreatic, breast and lung. AGR2 functions as a protein disulfide isomerase in the endoplasmic reticulum...
  63. Sung H, Choi E, Lyu D, Park A, Ju W, Ahn J. Aberrant hypomethylation-mediated AGR2 overexpression induces an aggressive phenotype in ovarian cancer cells. Oncol Rep. 2014;32:815-20 pubmed publisher
    ..The pro-oncogenic anterior gradient 2 (AGR2) gene showed increased mRNA expression and hypomethylation at CpG sites in its promoter region in the metastatic ..
  64. Di Maro G, Salerno P, Unger K, Orlandella F, Monaco M, Chiappetta G, et al. Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells. Mol Cancer. 2014;13:160 pubmed publisher
    Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC)...
  65. Hrstka R, Bouchalova P, Michalová E, Matoulkova E, Muller P, Coates P, et al. AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway. Mol Oncol. 2016;10:652-62 pubmed publisher
    ..We identified a novel pathway responsible for attenuation of p53 activity in human cancers. We demonstrate that AGR2, which is overexpressed in a variety of human cancers and provides a poor prognosis, up-regulates DUSP10 which ..
  66. Ye X, Sun M. AGR2 ameliorates tumor necrosis factor-?-induced epithelial barrier dysfunction via suppression of NF-?B p65-mediated MLCK/p-MLC pathway activation. Int J Mol Med. 2017;39:1206-1214 pubmed publisher
    ..Anterior gradient protein 2 homologue (AGR2) assists in maintaining intestinal homeostasis in dextran sulphate sodium-induced mouse ileocolitis; however, it is ..
  67. Dong A, Wodziak D, Lowe A. Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface. J Biol Chem. 2015;290:8016-27 pubmed publisher
    ..Here, we show using the NCI-H460 lung and A431 epidermoid human cancer cell lines that EGFR binding to anterior gradient homolog 2 (AGR2) in the endoplasmic reticulum is required for receptor delivery to the plasma membrane and thus ..
  68. Kim S, Jun S, Cho H, Lee D, Yeom Y, Kim J, et al. Knockdown of anterior gradient 2 expression extenuates tumor-associated phenotypes of SNU-478 ampulla of Vater cancer cells. BMC Cancer. 2014;14:804 pubmed publisher
    Anterior gradient 2 (AGR2) has been implicated in tumor-associated phenotypes such as cell viability, invasion and metastasis in various human cancers...
  69. Ma R, Zhao J, Chen X, Qiao X, Fan X, Du J, et al. Stabilization of ultra-small [Ag2]2+ and [Agm]n+ nano-clusters through negatively charged tetrahedrons in oxyfluoride glass networks: To largely enhance the luminescence quantum yields. Phys Chem Chem Phys. 2017;19:22638-22645 pubmed publisher
  70. Xue X, Fei X, Hou W, Zhang Y, Liu L, Hu R. miR-342-3p suppresses cell proliferation and migration by targeting AGR2 in non-small cell lung cancer. Cancer Lett. 2018;412:170-178 pubmed publisher
    b>AGR2 is a well-studied secreted protein that is involved in multiple biological processes including cell proliferation and migration...
  71. Rice G, Edgell T, Autelitano D. Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer. J Exp Clin Cancer Res. 2010;29:62 pubmed publisher
    ..with ovarian cancer; and to establish and compare the performance of MDK with that of anterior gradient 2 protein (AGR2) and CA125 in the development of multi-analyte classification algorithms for ovarian cancer...
  72. Shishkin S, Eremina L, Kovalev L, Kovaleva M. AGR2, ERp57/GRP58, and some other human protein disulfide isomerases. Biochemistry (Mosc). 2013;78:1415-30 pubmed publisher
    This review considers the major features of human proteins AGR2 and ERp57/GRP58 and of other members of the protein disulfide isomerase (PDI) family...