AGR2

Summary

Gene Symbol: AGR2
Description: anterior gradient 2
Alias: AG2, GOB-4, HAG-2, PDIA17, XAG-2, AG-2, HPC8, anterior gradient homolog 2, anterior gradient protein 2 homolog, protein disulfide isomerase family A, member 17, secreted cement gland homolog, secreted cement gland protein XAG-2 homolog
Species: human

Top Publications

  1. ncbi hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines
    D A Thompson
    Department of Surgery, Stanford University, Stanford, California, 94305 5494, USA
    Biochem Biophys Res Commun 251:111-6. 1998
  2. pmc The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
    Sung Woo Park
    Lung Biology Center and Program in Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:6950-5. 2009
  3. ncbi Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family
    Staffan Persson
    Department of Plant Biochemistry, Lund University, SE 22100 Lund, Sweden
    Mol Phylogenet Evol 36:734-40. 2005
  4. doi The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection
    Huajie Bu
    Department of Urology, Division of Experimental Urology, Innsbruck Medical University, Innsbruck, Austria
    Prostate 71:575-87. 2011
  5. pmc ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer
    Yuexing Zhang
    Greenebaum Cancer Center and Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 70:240-8. 2010
  6. pmc The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients
    Dong L Barraclough
    Cancer Tissue Bank Research Centre, University of Liverpool, UK
    Am J Pathol 175:1848-57. 2009
  7. ncbi Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation
    E Petek
    Institute of Medical Biology and Human Genetics, University of Graz, Austria
    Cytogenet Cell Genet 89:141-2. 2000
  8. ncbi AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer
    Jin San Zhang
    Department of Urology, Mayo Clinic College of Medicine, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 43:249-59. 2005
  9. ncbi Prognostic relevance of AGR2 expression in breast cancer
    Florian Rudolf Fritzsche
    Institute of Pathology and Breast Centre, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Clin Cancer Res 12:1728-34. 2006
  10. pmc hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan
    G C Fletcher
    Oxford GlycoSciences, Abingdon, Oxon, UK
    Br J Cancer 88:579-85. 2003

Research Grants

Detail Information

Publications133 found, 100 shown here

  1. ncbi hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines
    D A Thompson
    Department of Surgery, Stanford University, Stanford, California, 94305 5494, USA
    Biochem Biophys Res Commun 251:111-6. 1998
    ..Coexpression of hAG-2 with ER suggests that hAG-2 may be involved in the tumor biology specific to the well-differentiated phenotype of hormonally-responsive breast cancers...
  2. pmc The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
    Sung Woo Park
    Lung Biology Center and Program in Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:6950-5. 2009
    ..A recent homology-based search for additional PDI family members identified anterior gradient homolog 2 (AGR2), a protein originally presumed to be secreted by intestinal epithelial cells...
  3. ncbi Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family
    Staffan Persson
    Department of Plant Biochemistry, Lund University, SE 22100 Lund, Sweden
    Mol Phylogenet Evol 36:734-40. 2005
  4. doi The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection
    Huajie Bu
    Department of Urology, Division of Experimental Urology, Innsbruck Medical University, Innsbruck, Austria
    Prostate 71:575-87. 2011
    b>AGR2 is a member of the endoplasmatic reticulum protein disulphide isomerase gene family implicated in tumor metastasis. Its expression pattern, function, and utility as a marker remains to be further investigated.
  5. pmc ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer
    Yuexing Zhang
    Greenebaum Cancer Center and Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 70:240-8. 2010
    Dysregulation of the developmental gene anterior gradient protein 2 (AGR2) has been associated with a metastatic phenotype, but its mechanism of action and control in prostate cancers is unknown...
  6. pmc The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients
    Dong L Barraclough
    Cancer Tissue Bank Research Centre, University of Liverpool, UK
    Am J Pathol 175:1848-57. 2009
    The secreted metastasis-inducing protein, human anterior gradient 2 (AGR2), has been independently reported to be associated with either a reduced or an increased survival of different groups of patients with breast cancer...
  7. ncbi Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation
    E Petek
    Institute of Medical Biology and Human Genetics, University of Graz, Austria
    Cytogenet Cell Genet 89:141-2. 2000
  8. ncbi AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer
    Jin San Zhang
    Department of Urology, Mayo Clinic College of Medicine, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 43:249-59. 2005
    b>AGR2, the human homologue of Xenopus anterior gradient 2 (XAG2), was identified by a suppression subtractive hybridization-based technique as an androgen-inducible gene...
  9. ncbi Prognostic relevance of AGR2 expression in breast cancer
    Florian Rudolf Fritzsche
    Institute of Pathology and Breast Centre, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Clin Cancer Res 12:1728-34. 2006
    We aimed to evaluate the expression of the human anterior gradient-2 (AGR2) in breast cancer on RNA and protein level and to correlate it with clinicopathologic data, including patient survival.
  10. pmc hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan
    G C Fletcher
    Oxford GlycoSciences, Abingdon, Oxon, UK
    Br J Cancer 88:579-85. 2003
    ..hAG-2 and hAG-3 may therefore serve as useful molecular markers and/or potential therapeutic targets for hormone-responsive breast tumours...
  11. doi Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer
    Manuel Valladares-Ayerbes
    Medical Oncology and Institute for Biomedical Research INIBIC, Juan Canalejo University Hospital, Spain
    Cancer Detect Prev 32:236-50. 2008
    ..Our study aims to identify novel gastrointestinal cancer-specific markers for circulating tumor cell detection...
  12. ncbi Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients
    Y Zhang
    Molecular Pathology Laboratory, School of Cancer Studies, The University of Liverpool, Liverpool, UK
    Prostate Cancer Prostatic Dis 10:293-300. 2007
    Anterior gradient-2 (AGR2) expression was examined in a series of prostate cell lines and in an archival set of prostate tissues. The relative levels of AGR2 expression in the malignant cell lines PC-3 and PC-3M were, respectively, 5...
  13. ncbi Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma
    Marc Oliver Riener
    Institute of Surgical Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Histol Histopathol 24:1121-8. 2009
    The human Anterior Gradient-2 (AGR2) is strongly upregulated in various human cancers, including pancreatic ductal adenocarcinomas (PDAC), but its prognostic value in PDAC has not yet been studied.
  14. ncbi Physiological stress induces the metastasis marker AGR2 in breast cancer cells
    Daniel R Zweitzig
    Temple University School of Medicine, Fels Institute for Cancer Research, Philadelphia, PA 19140, USA
    Mol Cell Biochem 306:255-60. 2007
    ..These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen...
  15. doi Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival
    Vijaya Ramachandran
    Departments of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:7811-8. 2008
    ..In the current study, we investigated the role of anterior gradient 2 (AGR2) in these processes...
  16. pmc Anterior gradient-2 is overexpressed by fibrolamellar carcinomas
    Perumal Vivekanandan
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 40:293-9. 2009
    ..In conclusion, anterior gradient-2 is overexpressed in the majority of fibrolamellar carcinomas but is only rarely overexpressed in hepatocellular carcinomas...
  17. doi Reactivity of ammonia ligands of the antitumor agent cisplatin: a unique dodecanuclear Pt4,Pd4,Ag4 platform for four cytosine model nucleobases
    Gunnar Kampf
    Fakultat Chemie, Technische Universitat Dortmund, Otto Hahn Strasse 6, Dortmund, Germany
    Chemistry 14:6882-91. 2008
    ..Two of the four Ag ions (Ag2, Ag2') of 10 are labile in solution and show the expected behavior of Ag(+) ions in water, that is, they are ..
  18. pmc Fimbriae and the hemagglutinating adhesin HA-Ag2 mediate adhesion of Porphyromonas gingivalis to epithelial cells
    L Du
    Equipe de Biologie Buccale, UPRES EA 1256, , France
    Infect Immun 65:3875-81. 1997
    ..gingivalis to epithelial cells and that the adhesins are likely associated with fimbriae and the hemagglutinating adhesin HA-Ag2.
  19. ncbi [Chitinase B from Bacillus thuringiensis enhancing potential and its antagonism and insecticidal]
    Dong Liu
    Department of Microbiology, Nankai University, Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin 300071, China
    Wei Sheng Wu Xue Bao 49:180-5. 2009
    ..We studied the characteristics of chitinase B (ChiB) from Bacillus thuringiensis subsp. colmeri 15A3 (Bt 15A3) and evaluated its antagonism and insecticidal potential...
  20. ncbi Transfection of murine dendritic cell line (JAWS II) by a nonviral transfection reagent
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Biotechniques 35:600-2, 604. 2003
    ..for transfecting murine dendritic cells (JAWS II) with the gene that encodes Coccidioides immitis antigen 2 (Ag2). The JAWS II cells were cotransfected with pHYG-enhanced green fluorescent protein (EGFP) and pVR1012-C...
  21. ncbi Metal-induced alterations of delta-aminolevulinic acid dehydratase
    A Bernard
    Industrial Toxicology and Occupational Medicine Unit, University of Louvain, Brussels, Belgium
    Ann N Y Acad Sci 514:41-7. 1987
    ..experiments show that ALAD can be activated or inhibited by several metal ions including A;3+, Pb2+, Cd2+, Hg2+, Ag2+, and Cu2+...
  22. pmc Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells
    David H Tompkins
    Division of Pulmonary Biology in the Perinatal Institute, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 4:e8248. 2009
    ..constructs for differentiation markers characteristic of Clara, ciliated, and goblet cells, Scgb1a1, FoxJ1, and Agr2, respectively...
  23. pmc Coccidioidomycosis: host response and vaccine development
    Rebecca A Cox
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, Texas Research Park, 15355 Lambda Dr, San Antonio, TX 78245 3027, USA
    Clin Microbiol Rev 17:804-39, table of contents. 2004
    ..multiple candidates, but the single best individual immunogen is the protein termed antigen 2/proline-rich antigen (Ag2/PRA)...
  24. ncbi Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
    Josep Bassaganya-Riera
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Gastroenterology 127:777-91. 2004
    ..We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism...
  25. ncbi Amendment with peony root bark improves the biocontrol efficacy of Trichoderma harzianum against Rhizoctonia solani
    Tae Ok Lee
    Department of Agricultural Biotechnology and Center for Plant Molecular Genetics and Breeding Research, Seoul National University, Seoul 151 921, Korea
    J Microbiol Biotechnol 18:1537-43. 2008
    We tested Trichoderma harzianum as a biocontrol agent for Rhizoctonia solani AG2-1, using six natural antifungal materials to improve its efficacy...
  26. pmc SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
    Gang Chen
    The Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 119:2914-24. 2009
    ..goblet cell differentiation and protein glycosylation, including forkhead box A3 (Foxa3), anterior gradient 2 (Agr2), and glucosaminyl (N-acetyl) transferase 3, mucin type (Gcnt3)...
  27. ncbi Polymorphisms in the Paan-AG promoter influence NF-kappaB binding and transcriptional activity
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    Immunogenetics 59:359-66. 2007
    ..We cloned the promoters of two putative Paan-AG alleles (AG1 and AG2) and identified a number of regulatory elements including two kappaB sites...
  28. doi Metabolite composition and bioactivity of Rhizoctonia solani sclerotial exudates
    Konstantinos A Aliferis
    Department of Plant Science, McGill University, 21111 Lakeshore Road, Sainte Anne de Bellevue, QC H9X 3V9, Canada
    J Agric Food Chem 58:7604-15. 2010
    ..The sclerotia of the plant pathogen Rhizoctonia solani AG2-2 IIIB exude liquid brown droplets that were evaluated for their bioactivity and toxicity against microorganisms ..
  29. ncbi Recent advances in serodiagnosis for cysticercosis
    Y Sako
    Department of Parasitology, Asahikawa Medical College, Hokkaido, Japan
    Southeast Asian J Trop Med Public Health 32:98-104. 2001
    ..proteins, we carried out molecular cloning and identified four diagnostic antigen candidates (Ag1, Ag1V1, Ag2, and Ag2V1)...
  30. ncbi Safety, antigenicity, and efficacy of a recombinant coccidioidomycosis vaccine in cynomolgus macaques (Macaca fascicularis)
    Suzanne M Johnson
    D V M M P V M, California National Primate Research Center, University of California, Davis, CA 95616, USA
    Ann N Y Acad Sci 1111:290-300. 2007
    The safety, immunogenicity and efficacy of recombinant Ag2/PRA106 + CSA chimeric fusion protein (CFP) vaccine in ISS/Montanide adjuvant-administered intramuscular (IM) was assessed in adult female cynomolgus macaques challenged with ..
  31. ncbi Rapid diagnosis of coccidioidomycosis by nested PCR assay of sputum
    R de Aguiar Cordeiro
    Medical Mycology Specialized Center, Post Graduation Program in Medical Sciences, Federal University of Ceara, Ceara, Brazil
    Clin Microbiol Infect 13:449-51. 2007
    ..posadasii DNA in an inappropriate sputum sample by PCR amplification of the highly specific Ag2/PRA antigen gene...
  32. ncbi Establishment of 8-azaguanine-resistant mutants from rat thyroid cell line FRTL-5
    H Sugawa
    Second Division of Internal Medicine, Kyoto University School of Medicine, Japan
    Mol Cell Endocrinol 62:319-26. 1989
    ..were further selected in 6-thioguanine-containing medium, and two mutant clones were finally obtained (AG1 and AG2)...
  33. doi Coccidioidal pericarditis: a rapid presumptive diagnosis by an in-house antigen confirmed by mycological and molecular methods
    Raimunda S N Brilhante
    Specialized Medical Mycology Center, Federal University of Ceara, Fortaleza, Ceara, Brazil
    J Med Microbiol 57:1288-92. 2008
    ..posadasii in-house antigen preparation. The C. posadasii identification was confirmed by nested PCR of the antigen 2/proline-rich antigen (Ag2/PRA) encoding gene.
  34. ncbi Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2
    F Aberger
    Institute of Genetics, University of Salzburg, Hellbrunnerstrasse 34, A 5020, Salzburg, Austria
    Mech Dev 72:115-30. 1998
    ..Based on these findings we propose a role for XAG-2 in the specification of dorsoanterior ectodermal fate, i.e. in the formation of cement gland and induction of forebrain fate of Xenopus...
  35. ncbi Sequence and expression of Drosophila Antigen 5-related 2, a new member of the CAP gene family
    T Megraw
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington, IN, USA
    Gene 222:297-304. 1998
    ..Because of its similarity to Agr, this novel cDNA was termed Antigen 5-related 2 (Agr2)...
  36. doi Strain-specific colonization pattern of Rhizoctonia antagonists in the root system of sugar beet
    Christin Zachow
    Institute of Environmental Biotechnology, Graz University of Technology, Graz, Austria
    FEMS Microbiol Ecol 74:124-35. 2010
    ..The survival and colonization patterns of five different biocontrol agents against Rhizoctonia solani AG2-2IIIB in the rhizosphere of greenhouse-grown sugar beet plants were analysed in single and combined treatments...
  37. pmc Time-varying changes in corticospinal excitability accompanying the triphasic EMG pattern in humans
    C D MacKinnon
    MRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Physiol 528:633-45. 2000
    ..by the usual triphasic pattern of EMG activity in agonist (AG1), antagonist (ANTAG) and again in agonist (AG2) muscles...
  38. ncbi Coccidioides immitis antigen 2: analysis of gene and protein
    Y Zhu
    Department of Clinical Investigation, Texas Center for Infectious Disease, San Antonio 78223, USA
    Gene 181:121-5. 1996
    ..Using oligodeoxyribonucleotide (oligo) primers based on the sequences of Ag2 cDNA, the gene encoding Ag2 was cloned from genomic DNA derived from the mycelial phase of C. immitis by PCR...
  39. doi Muscle activity patterns during quick increase of movement amplitude in rapid elbow extensions
    Nozomi Takatoku
    Graduate School of Humanities and Sciences, Nara Women s University, Nara, Japan
    J Electromyogr Kinesiol 20:290-7. 2010
    ..e., the first agonist burst (AG1), the second agonist burst (AG2) and the antagonist burst (ANT), for increasing the amplitude of movement required after the initiation of movement...
  40. doi Global distribution and evolution of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus, 1981-2007
    Jean Philippe Rasigade
    Universite Lyon 1, Centre National de Référence des Staphylocoques, and Institut National de la Santé et de la Recherche Médicale U851, Institut Fédératif de Recherche 128, Lyon, France
    J Infect Dis 201:1589-97. 2010
    ..The epidemiological profile of PVL-positive community-acquired (CA) MRSA has been extensively studied, but few corresponding data on PVL-positive MSSA are available...
  41. ncbi Formation of mixed d- and f-block metal clusters in inert matrices: comparison of the observed and theoretical optical spectra of AgHo
    W E Klotzbücher
    Max Planck lnstitut für Strahlenchemie, Mülheimn a d Ruhr, Germany
    Spectrochim Acta A Mol Biomol Spectrosc 57:1093-101. 2001
    ..for the electronic excitation energies and corresponding transition dipole moments for the diatomic molecules Ag2, Ho2, AgHo provide evidence that the 430 nm band should be attributed to the mixed cluster AgHo (theoretical band ..
  42. pmc Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer
    Philip S Rudland
    Cancer and Polio Research Fund Laboratories, School of Biological Sciences, Biosciences Building, Crown Street, University of Liverpool, Liverpool, L69 3BX, United Kingdom
    Am J Pathol 176:2935-47. 2010
    ..associated with positive staining for the metastasis-inducing proteins S100A4, S100P, osteopontin, and AGR2 (P < or = 0.002). Survival of patients with FANCD2-negative carcinomas was significantly worse (P < 0...
  43. ncbi Strategic expression of ion transport peptide gene products in central and peripheral neurons of insects
    Li Dai
    Department of Entomology, University of California, Riverside, California 92521, USA
    J Comp Neurol 500:353-67. 2007
    ..is observed in two pairs of small lateral neurons in the brain and one pair of ventromedial neurons in each of AG2-6. A similar pattern of differential ITP and ITPL expression was observed in the CNS and PNS of B...
  44. doi Synthesis and binding analysis of unique AG2 pentasaccharide to human Siglec-2 using NMR techniques
    Shinya Hanashima
    Structural Glycobiology Team, RIKEN Advanced Science Institute, Hirosawa 2 1, Saitama 351 0198, Japan
    Bioorg Med Chem 18:3720-5. 2010
    ..We synthesized a unique starfish ganglioside, AG2 pentasaccharide Galfbeta(1-3)Galpalpha(1-4)Neu5Acalpha(2-3)Galpbeta(1-4)Glcp, and found that the synthetic ..
  45. ncbi Allergy to rabbits. III. Further identification and characterisation of rabbit allergens
    J A Warner
    Child Health, Southampton University, UK
    Allergy 46:481-91. 1991
    ..Other allergens were only recognised by highly rabbit-sensitive individuals, one in particular (Ag2) being present in several source materials...
  46. pmc SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells
    Taeko K Noah
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Exp Cell Res 316:452-65. 2010
    ..to activate goblet cell gene expression, shRNAs that inhibited SPDEF also repressed expression of goblet cell genes AGR2, MUC2, RETLNB, and SPINK4...
  47. pmc Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice
    Fang Zhao
    Department of Medicine and Biological Chemistry, University of California, Irvine, CA, USA
    Dev Biol 338:270-9. 2010
    Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that plays important roles in diverse processes in multiple cell lineages as a developmental regulator, survival factor and susceptibility gene for inflammatory bowel disease...
  48. doi Predominant expression and cellular distribution of fish Agr2 in renal collecting system
    Jian Hong Xia
    Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan, China
    Comp Biochem Physiol B Biochem Mol Biol 152:397-404. 2009
    Anterior gradient 2 (Agr2) genes encode secretory proteins, and play significant roles in anterior-posterior patterning and tumor metastasis...
  49. doi A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin
    Magdalena M Maslon
    Cancer Research UK p53 Signal Transduction Laboratories, Cell Signalling Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EX4 2XR, Scotland, UK
    J Mol Biol 404:418-38. 2010
    Anterior gradient-2 (AGR2) functions in a range of biological systems, including goblet cell formation, limb regeneration, inhibition of p53, and metastasis...
  50. doi Heteroleptic Silver(I) Complexes Prepared from Phenanthroline and Bis-phosphine Ligands
    Adrien Kaeser
    Laboratoire de Chimie des Matériaux Moléculaires, Université de Strasbourg et CNRS UMR 7509, 25 rue Becquerel, 67087 Strasbourg Cedex 2, France
    Inorg Chem 52:14343-54. 2013
    ..e., [Ag2(NN)2(μ-dppm)2](2+) and [Ag2(NN)2(μ-dppp)2](2+) with NN = phen or Bphen (bathophenanthroline), have been isolated ..
  51. pmc Proteomic changes during intestinal cell maturation in vivo
    Jinsook Chang
    Center for Proteomics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Proteomics 71:530-46. 2008
    ..Three novel paneth cell markers, AGR2, HSPA5 and RRBP1 were also identified...
  52. doi Anterior gradient 2 and mucin 4 expression mirrors tumor cell differentiation in pancreatic adenocarcinomas, but aberrant anterior gradient 2 expression predicts worse patient outcome in poorly differentiated tumors
    Veronika Brychtova
    From the Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute First Department of Pathological Anatomy, St Anne s University Hospital, Medical Faculty of Masaryk University Department of Complex Oncology Care, Masaryk Memorial Cancer Institute Department of Mathematics and Statistics, Faculty of Science, Masaryk University and Department of Surgery, University Hospital Brno, Medical Faculty of Masaryk University, Brno, Czech Republic
    Pancreas 43:75-81. 2014
    This study aimed to determine anterior gradient 2 (AGR2) expression in biopsies from pancreatic ductal adenocarcinomas (PDACs) and to evaluate AGR2 as a potential independent prognostic factor.
  53. pmc "Prostate cancer proteomics" database
    S S Shishkin
    Bach Institute of Biochemistry, Russian Academy of Sciences
    Acta Naturae 2:95-104. 2010
    ..PCP contains data on 359 proteins in total, including 17 potential biomarkers of prostate cancer, particularly AGR2, annexins, S100 proteins, PRO2675, and PRO2044...
  54. doi Purification and characterization of a thermostable α-galactosidase from Thielavia terrestris NRRL 8126 in solid state fermentation
    Rawia R Saad
    Biological and Geological Sciences Department, Faculty of Education Ain Shams University, Heliopolis, Roxy, Cairo Egypt
    Acta Biol Hung 63:138-50. 2012
    ..Km of the purified enzyme was 1.31 mM. The purified enzyme was inhibited by Ag2+, Hg2+, Zn2+, Ba2+, Mg2+, Mn2+ and Fe2+ at 5 mM and 10 mM...
  55. ncbi Fabrication of luminescent silver doped PbS nanowires in polymer
    Swapan K Mandal
    Department of Physics, Visva Bharati, Santiniketan 731235, India
    J Nanosci Nanotechnol 11:10234-9. 2011
    ..76 mol%) indicating strong modification of the electronic states by magnetic silver ions. While Ag2+ centers at the substitutional lattice site show an emission band around 525 nm, Ag0 at the interstitial site act ..
  56. doi IPH-926 lobular breast cancer cells are triple-negative but their microarray profile uncovers a luminal subtype
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Cancer Sci 104:1726-30. 2013
    ..Quantitative real-time RT-PCR confirmed enhanced expression of luminal marker genes (AGR2, CLU, CA12, EMP2, CLDN3) and low or absent expression of basal marker genes (KRT5, CD44, CAV1, VIM)...
  57. doi A novel three-dimensional AgI coordination polymer based on mixed naphthalene-1,5-disulfonate and aminoacetate ligands
    Hua Wu
    College of Science, Nanjing Agricultural University, Nanjing 210095, People s Republic of China
    Acta Crystallogr C 69:876-9. 2013
    ..and 2-aminoacetate (L2) ligands, contains two Ag(I) centres (Ag1 and Ag4) in general positions, and another two (Ag2 and Ag3) on inversion centres...
  58. doi Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype
    Kian Kani
    University of Southern California, Los Angeles, California 90033, USA
    Prostate 73:306-15. 2013
    Anterior gradient 2 (AGR2) is associated with metastatic progression in prostate cancer cells as well as other normal and malignant tissues. We investigated AGR2 expression in patients with metastatic prostate cancer.
  59. doi Formation of Ag2S cages from polyhedral Ag2O nanocrystals and their electrochemical properties
    Lian Ming Lyu
    Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan
    Chem Asian J 8:1847-53. 2013
    ..The ability to easily fabricate thin sheets of Ag2S over different Ag2O surfaces should extend the applications of Ag2S nanostructures...
  60. doi Influence of a thioether function in short-bite diphosphine ligands on the nature of their silver complexes: structure of a trinuclear complex and of a coordination polymer
    Vitor Rosa
    Laboratoire de Chimie de Coordination, Institut de Chimie UMR 7177 CNRS, Universite de Strasbourg, 4 rue Blaise Pascal, CS 90032, 67081 Strasbourg, France
    Dalton Trans 42:12109-19. 2013
    ..In contrast, ligand L2 led to the coordination polymer [{Ag2(μ3-L2,-P,P,S)2(MeCN)2}{Ag2(μ2-L2-P,P)2(MeCN)2}(BF4)4]n (2) in which the tethered thioether group connects ..
  61. pmc Directed amination of non-acidic arene C-H bonds by a copper-silver catalytic system
    Ly Dieu Tran
    Department of Chemistry, University of Houston, Houston, TX 77204 5003, USA
    Angew Chem Int Ed Engl 52:6043-6. 2013
    ..The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional-group tolerance, as well as providing a straightforward means for the preparation of ortho-aminobenzoic acid derivatives...
  62. pmc catena-Poly[silver(I)-bis-[μ-4-methyl-1H-1,2,4-triazole-3(4H)-thione-κ(2) S:S]-silver(I)-di-μ-thio-cyanato-κ(2) S:N;κ(2) N:S]
    Kultida Kodcharat
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    Acta Crystallogr Sect E Struct Rep Online 69:m265-6. 2013
    In the title one-dimensional coordination polymer, [Ag2(NCS)2(C3H5N3S)2] n , the Ag(I) atom adopts a distorted tetra-hedral AgNS3 geometry...
  63. ncbi Tunneling splitting of Jahn-Teller ions in oxides
    P Garcia-Fernandez
    Departamento de Ciencias de la Tierra y Fisica de la Materia Condensada, Universidad de Cantabria, Avenida de los Castros s n 39005 Santander, Spain
    Phys Rev Lett 104:035901. 2010
    ..Values associated with Cu2+- and Ag2+-doped MgO are 2 orders of magnitude larger than those previously assumed and consistent with the existence of a ..
  64. doi CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma
    Larissa Sweeny
    Department of Surgery, University of Alabama, Division of Otolaryngology Head and Neck Surgery, Birmingham, Alabama, USA
    Exp Cell Res 318:1788-98. 2012
    ..CD147 is a transmembrane glycoprotein known to induce cell migration and invasion. AGR2 is a secreted peptide also known to promote cell metastasis...
  65. ncbi Effect of diatomaceous earth and Trichoderma harzianum T-22 (Rifai strain KRL-AG2) on the fungus gnat Bradysia sp. nr. coprophila (Diptera: Sciaridae)
    Raymond A Cloyd
    Department of Entomology, Kansas State University, Manhattan, KS 66506, USA
    J Econ Entomol 100:1353-9. 2007
    ..eggs; and whether fungus gnat adults are attracted to the fungus Trichoderma harzianum T-22 (Rifai strain KRL-AG2) under laboratory conditions...
  66. ncbi Th1-type immune response to a Coccidioides immitis antigen delivered by an attenuated strain of the non-invasive enteropathogen Vibrio cholerae
    Anisia J Silva
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr, SW Atlanta, GA 30310 1495, USA
    FEMS Immunol Med Microbiol 43:393-8. 2005
    The antigen-2 or proline rich antigen (Ag2/PRA) from Coccidioides immitis, known to protect mice against experimental Coccidioidomycosis, was expressed in the genetically attenuated cholera vaccine candidate Vibrio cholerae 638 and its ..
  67. pmc Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: a combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping
    Michael A DiMaio
    Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Hum Pathol 43:1799-807. 2012
    ..markers (p63, cytokeratin 5/6, cytokeratin 7, CDX2, MUC2, and MUC5AC) and 2 new markers, anterior gradient homolog 2 and SOX2, in esophageal carcinomas to establish the best panel to distinguish these tumors...
  68. ncbi Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue
    C L Wilson
    Cancer Research UK Bioinformatics Group, Paterson Institute for Cancer Research, Wilmslow Road, Withington, Manchester M20 4BX, UK
    Endocr Relat Cancer 13:617-28. 2006
    ..as TFF1 and AREG), and genes thought to be involved in breast cancer metastasis (including mammoglobin, KRT19 and AGR2), were upregulated in response to E treatment...
  69. ncbi Coordination networks with fluorinated backbones
    Ye Gao
    Department of Chemistry, University of Idaho, Moscow, Idaho 83843 2343, USA
    Inorg Chem 45:1150-5. 2006
    ..AgNO3, Co(ClO4)2 x 6 H2O, and Cd(NO3)2 x 4 H2O, respectively, to form the following structures: 3D channel polymer [Ag2(1)2(NO3)2 x H2O x MeOH]n (3), 2D sheet polymer [Co(1)3(ClO4)2]n (4), 1D chain polymer [Cd(1)3(NO3)2 x 4 H2O]n (5), ..
  70. ncbi [Identification of AGR2 protein, a novel potential cancer marker, using proteomics technologies]
    L I Kovalev
    Prikl Biokhim Mikrobiol 42:480-4. 2006
    ..0 was observed in four of the cancer cases. Mass spectrometry allowed this protein to be identified as the androgen-induced secreted protein AGR2. The possibility of using AGR2 as a diagnostic marker of prostate cancer is discussed.
  71. ncbi Identification of somatostatin receptors controlling growth hormone and thyrotropin secretion in the chicken using receptor subtype-specific agonists
    K L Geris
    Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamsestraat 61, B 3000 Leuven, Belgium
    J Endocrinol 177:279-86. 2003
    ..In both the static and flow incubations, ag2 lowered the GH response to TRH, whereas stimulated TSH release was diminished by both ag2 and ag5...
  72. ncbi Global gene expression profiling of circulating tumor cells
    Denis A Smirnov
    Immunicon Corporation, Huntingdon Valley, Pennsylvania 19006, USA
    Cancer Res 65:4993-7. 2005
    ..Genes such as AGR2, S100A14, S100A16, FABP1, and others were found useful for detection of CTCs in peripheral blood of advanced cancer ..
  73. doi Monolacunary Keggin polyoxometalates connected to ten 4d or 4f metal atoms
    Haijun Pang
    Key Lab of Polyoxometalate Science, Department of Chemistry, Northeast Normal University, Changchun 130024, P R China
    Dalton Trans 42:16596-601. 2013
    ..4d-4f heterometallic compounds containing lacunary Keggin anions connected to ten metal atoms: {[Ag{Ag2(H2O)4}{Ln(H2O)6}2H ⊂ {SiW11Ln(H2O)4O39}2]·nH2O (Ln = Ce and n = 7 for 1, Ln = Pr and n = 3 for 2)...
  74. ncbi Gold(I) and silver(I) mixed-metal trinuclear complexes: dimeric products from the reaction of gold(I) carbeniates or benzylimidazolates with silver(I) 3,5-diphenylpyrazolate
    Ahmed A Mohamed
    Laboratory for Molecular Structure and Bonding, Department of Chemistry, Texas A and M University, College Station, Texas 77843 3255, USA
    Inorg Chem 45:7770-6. 2006
    ..The crystalline products are mixed-ligand, mixed-metal dimeric products [Au(carb)Ag2(mu-3,5-Ph2pz)2], [Au2(carb)2Ag(mu-3,5-Ph2pz)]...
  75. doi Syntheses, crystal structures and photophysical properties of Ag(I) coordination complexes
    Yu Xian Chi
    School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 106:203-9. 2013
    ..In complex 3, two crystallographic independent Ag(I) ions exist, i.e., Ag1 is three-coordinate and Ag2 is two-coordinate, forming the 2D layer structure...
  76. doi Proteomic study explores AGR2 as pro-metastatic protein in HCC
    Hongxiu Yu
    Institutes of Biomedical Sciences, Fudan University, 130 Dong an Road, Shanghai, P R China 200032
    Mol Biosyst 8:2710-8. 2012
    ..We found that high-expression levels of AGR2 existed in metastatic HCC cell lines and patient samples...
  77. doi An accurate and rapid detection of lymph node metastasis in non-small cell lung cancer patients based on one-step nucleic acid amplification assay
    Masayoshi Inoue
    Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Lung Cancer 78:212-8. 2012
    ..Cytokeratin 19 (CK19), cytokeratin 7 (CK7), stratifin (SFN), and anterior gradient homolog 2 (AGR2) showed significant differences for mRNA expression between metastasis-negative and -positive ..
  78. doi Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78
    Joohyun Ryu
    Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon 305 333, Republic of Korea
    Biochem Biophys Res Commun 430:610-5. 2013
    Anterior Gradient 2 (AGR2), an ER stress-inducible protein, has been reported to be localized in endoplasmic reticulum (ER) and its level is elevated in numerous metastatic cancers...
  79. doi Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells
    Huajie Bu
    Department of Urology, Innsbruck Medical University, Innsbruck, Austria
    FEBS J 280:1249-66. 2013
    ..In the present study, we analyzed the effect of androgens and oestrogens on the expression of anterior gradient 2 (AGR2) and anterior gradient 3 (AGR3), comprising two highly-related genes encoding secretory proteins that are expressed ..
  80. doi Anion-π interactions in supramolecular architectures
    Helen T Chifotides
    Department of Chemistry, Texas A and M University, College Station, Texas 77842, United States
    Acc Chem Res 46:894-906. 2013
    ..The X-ray data revealed that the higher π-acidity of the tetrazine ring in bptz leads to propeller-type products [Ag2(bptz)3](2+) exhibiting prominent short anion-π contacts...
  81. doi Anterior gradient 2 profiling in Barrett columnar epithelia and adenocarcinoma
    Marco Pizzi
    Department of Medical Diagnostic Sciences and Special Therapies, Surgical Pathology and Cytopathology Unit, University of Padova, 35100 Padova, Italy
    Hum Pathol 43:1839-44. 2012
    ..This study supports the biological similarity of the nonintestinal and intestinal types of Barrett metaplasia as precursors of Barrett adenocarcinoma...
  82. pmc AGR2 is induced in asthma and promotes allergen-induced mucin overproduction
    Bradley W Schroeder
    Lung Biology Center, Department of Medicine, University of California San Francisco, USA
    Am J Respir Cell Mol Biol 47:178-85. 2012
    ..The endoplasmic reticulum (ER) protein anterior gradient homolog 2 (AGR2) is required for production of the intestinal mucin MUC2, but its role in the production of the ..
  83. pmc Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2
    Shanru Li
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 139:2500-9. 2012
    ..goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2). Forced expression of Agr2 is sufficient to promote the goblet cell fate in the developing airway epithelium...
  84. ncbi Grid expansion: a rhombiclike [L4Fe2(Ag2)2] complex containing Ag2 dumbbells at two vertices
    Benjamin Schneider
    Institute of Inorganic Chemistry, Georg August University Gottingen, Tammannstraße 4, D 37077 Gottingen, Germany
    Inorg Chem 51:4912-4. 2012
    ....
  85. doi Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine
    Elizabeth A Wayner
    Antibody Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 72:1023-34. 2012
    Comparative transcriptomics between sorted cells identified AGR2 as one of the highest up-regulated genes in cancer. Overexpression in primary tumors was verified by tissue microarray analysis...
  86. doi Arbuscular mycorrhizal protein mRNA over-expression in bread wheat seedlings by Trichoderma harzianum Raifi (KRL-AG2) elicitation
    Adnan A S Al-Asbahi
    Department of Biology, University of Sana a, Sana a, P O Box 14686, Yemen
    Gene 494:209-13. 2012
    ..The result of this study can spark future researches to elucidate possible role of this protein in the symbiotic interaction mechanisms between soil AMF and various plant roots...
  87. doi Identification of six potential markers for the detection of circulating canine mammary tumour cells in the peripheral blood identified by microarray analysis
    A Da Costa
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    J Comp Pathol 146:143-51. 2012
    ..Six mRNA markers, AGR2, ATP8B1, CRYAB, F3 IRX3 and SLC1A1 were expressed in cell lines, but not PBL...
  88. doi Mapping a noncovalent protein-peptide interface by top-down FTICR mass spectrometry using electron capture dissociation
    David J Clarke
    SIRCAMS, EaStCHEM School of Chemistry, University of Edinburgh, Edinburgh, UK
    J Am Soc Mass Spectrom 22:1432-40. 2011
    ..supported by a solution-phase competition assay, which implicates the region between residues 108 and 122 within AGR2 as the PTTIYY binding interface...
  89. doi Preparation and characterization of antibacterial P₂O5-CaO-Na₂O-Ag₂O glasses
    A A Ahmed
    Glass Research Department, National Research Centre, Dokki, Cairo 12622, Egypt
    J Biomed Mater Res A 98:132-42. 2011
    ..For silver-free glasses, an increase in IZD was observed with the increase in the glass dissolution rate and with the decrease in pH of water. Also, the IZD showed an increase with increasing Ag₂O content of silver-doped glasses...
  90. pmc Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis
    Arisa Higa
    Inserm U1053, Avenir, 33076 Bordeaux, France
    J Biol Chem 286:44855-68. 2011
    The protein-disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) is reportedly overexpressed in numerous cancers and plays a role in cancer development...
  91. ncbi Targetting the production of monoclonal antibodies to the hemagglutinating adhesin of Bacteroides (Porphyromonas) gingivalis by injection of an immunoprecipitate from crossed immunoelectrophoresis
    M Deslauriers
    Groupe de Recherche en Ecologie Buccale, , , , Canada
    J Biol Buccale 19:155-60. 1991
    ..The target antigen was the hemagglutinating adhesin HA-Ag2 of Bacteroides (Porphyromonas) gingivalis precipitated from a crude antigen extract with a rabbit antiserum in ..
  92. doi Genotypic and phenotypic variation among Lysobacter capsici strains isolated from Rhizoctonia suppressive soils
    J Postma
    Plant Research International, P O Box 69, 6700 AB Wageningen, The Netherlands
    Syst Appl Microbiol 33:232-5. 2010
    ..capsici. The newly identified L. capsici strains strongly inhibit Rhizoctonia solani AG2 and originate from Rhizoctonia-suppressive soils where also populations of L. antibioticus and L...
  93. ncbi [Study of density functional theory for surface-enhanced Raman spectra of p-aminothiophenol]
    Yan Chen
    College of Physical Science and Technology, Central South University, Changsha 410083, China
    Guang Pu Xue Yu Guang Pu Fen Xi 31:2952-5. 2011
    ..NRS) spectrum of PATP and the surface-enhanced Raman scattering(SERS) spectrum of PATP adsorbed on Ag and Ag2 were both calculated, and were compared with the results of other literatures values...
  94. ncbi Molecular size variation of the hemagglutinating adhesin HA-Ag2, a common antigen of Bacteroides gingivalis
    F Chandad
    , , , , Canada
    Can J Microbiol 36:690-6. 1990
    ..one antigen that is associated with an erythrocyte-binding capacity, termed the hemagglutinating adhesin HA-Ag2. This antigen was excised from crossed-immunoelectrophoresis plates to produce two polyclonal antisera, VL 011 and ..
  95. pmc Immunochemical identification and preliminary characterization of a nonfimbrial hemagglutinating adhesin of Bacteroides gingivalis
    C Mouton
    , , , Canada
    Infect Immun 57:566-73. 1989
    A cell-bound hemagglutinating adhesin (HA-Ag2) of Bacteroides gingivalis was identified by crossed immunoaffinity electrophoresis as one of the common antigens of the species...
  96. pmc PCR assays for identification of Coccidioides posadasii based on the nucleotide sequence of the antigen 2/proline-rich antigen
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tübingen Institute of Medical Microbiology, University of Regensburg, Germany
    J Clin Microbiol 42:778-83. 2004
    ..The gene encoding the specific antigen 2/proline-rich antigen (Ag2/PRA) was used as a target...
  97. ncbi [Vaccination of rhesus monkeys with recombinant antigen fragments and protection from hepatitis E virus infection]
    Yan bing Ma
    Department of Molecular Biology, Institute of Medical Biology, CAMS, PUMC, Kunming 650118, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:592-5. 2002
    ..To observe anti-HEV IgG response to vaccination of recombinant antigen fragments and evaluate its protection from Hepatitis E Virus infection in rhesus monkeys (Macaca mulatta)...
  98. ncbi Serodiagnosis of Trypanosoma cruzi infection using the new particle gel immunoassay--ID-PaGIA Chagas
    A Rabello
    Centro de Pesquisas Rene Rachou Fiocruz, MG, Brasil
    Mem Inst Oswaldo Cruz 94:77-82. 1999
    ..are sensitised with three different synthetic peptides representing antigen sequences of Trypanosoma cruzi: Ag2, TcD and TcE. When these particles are mixed with serum containing specific antibodies, they agglutinate...
  99. ncbi Expression cloning of the Candida albicans CSA1 gene encoding a mycelial surface antigen by sorting of Saccharomyces cerevisiae transformants with monoclonal antibody-coated magnetic beads
    C Lamarre
    Departement de Biochimie et de Microbiologie, Centres de Recherche, la Fonction et l Ingénierie des Protéines CREFSIP de l Université Laval, Quebec, Canada G1K 7P4
    Mol Microbiol 35:444-53. 2000
    ..cysteine-rich hydrophobic domains with significant sequence similarity to motifs found in surface proteins (Ag2 and Pth11) from two distantly related fungal pathogens (Coccidioides immitis and Magnaporthe grisea respectively) ..
  100. ncbi Identification and cataloging of genes induced by long-lasting long-term potentiation in awake rats
    R Matsuo
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan Institute of Medical Sciences, University of Tokyo, Japan
    J Neurochem 74:2239-49. 2000
    ..genes whose up-regulation by LTP has already been reported (MAPK phosphatase, NGFI-A/zif268, vesl-1S/homer-1a, Ag2, and krox-20)...
  101. pmc Epitope mapping of hemagglutinating adhesion HA-Ag2 of Bacteroides (Porphyromonas) gingivalis
    M Deslauriers
    Groupe de Recherche en Ecologie Buccale, , , Canada
    Infect Immun 60:2791-9. 1992
    Thirteen monoclonal antibodies (MAbs) directed against hemagglutinating adhesion HA-Ag2 of Bacteroides (Porphyromonas) gingivalis were produced by immunizing mice with the relevant immunoprecipitate from crossed immunoelectrophoresis (..

Research Grants33

  1. Determinants of AGR2 effects in Barrett's esophagus and esophageal adenocarcinoma
    Anson W Lowe; Fiscal Year: 2010
    ..During the last funding period, gene expression analysis revealed that compared to normal esophageal tissue, the AGR2 gene is highly expressed in Barrett's esophagus and esophageal adenocarcinoma...
  2. Airway Epithelial Responses to Allergic Inflammation
    David J Erle; Fiscal Year: 2010
    ..The other IL-13-induced gene encodes the goblet cell-specific secreted protein anterior gradient 2 (AGR2), which is a member of a family of proteins involved in cell adhesion and migration and in differentiation of mucus ..
  3. Airway Epithelial Responses to Allergic Inflammation
    David Erle; Fiscal Year: 2007
    ..The other IL-13-induced gene encodes the goblet cell-specific secreted protein anterior gradient 2 (AGR2), which is a member of a family of proteins involved in cell adhesion and migration and in differentiation of mucus ..
  4. TEAR GLAND FLUID FORMATION
    AUSTIN MIRCHEFF; Fiscal Year: 1993
    ..Preliminary data confirm that acinar cells contain a potentially immunogenic protein (LG- Ag2) and that they can express several components of the machinery for antigen presentation, including cathepsin B, ..
  5. Specialized molecules with essential roles in mucus production
    David J Erle; Fiscal Year: 2010
    ..We recently discovered that the protein anterior gradient homolog 2 (AGR2) plays an essential role in mucus production...
  6. CELLULAR ASSEMBLY AND TRANSPORT OF THE IGE RECEPTOR
    Michael Robertson; Fiscal Year: 2004
    ..events occur during FceRI ct-chain biosynthesis that profoundly influence the formation of a transport competent ag2 receptor: (i) glycosidase-mediated processing of a-chain core oligosaccharides in the ER and; (ii) the association ..
  7. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  8. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  9. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2007
    ..Relevance of this research to public health: By achieving early ovarian cancer diagnosis, it will be possible to reduce the burden of the disease by administration of effective treatment as early as possible. ..
  10. Molecular Cloning of the Wilms tumor Gene from 7p15-21
    Khalid Sossey Alaoui; Fiscal Year: 2004
    ..Understanding the nature of the genetic events which allow these cells to escape their normal growth regulation may also provide an opportunity for therapeutic intervention. ..
  11. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  12. Regulation of the baboon HLA-G-like class Ib MHC gene, Paan-AG
    DAUDI LANGAT; Fiscal Year: 2007
    ..Thus the baboon is clearly an excellent model for HLA-G functional experiments, and testing the therapeutic applications of HLA-G in human pregnancy and transplantation. ..
  13. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2009
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  14. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2007
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..